SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'HEX'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DVX_B_DIFB125_1
(TRANSTHYRETIN)		 2gsk VITAMIN B12
TRANSPORTER BTUB
(Escherichia
coli) 		4 / 7 ALA A 252
LEU A 254
SER A 263
THR A 267
 HEX  A 807 ( 3.9A)
None
None
HEX  A 807 (-3.4A)
 0.52A 1dvxA-2gskA:
undetectable		 1dvxA-2gskA:
12.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TEH_B_DAHB786_1
(PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN)		 2ynk WZI
(Escherichia
coli) 		4 / 7 GLY A 293
GLU A 319
ALA A 253
PHE A 294
 None
None
HEX  A1016 ( 3.7A)
None
 0.87A 3tehB-2ynkA:
undetectable		 3tehB-2ynkA:
20.47