SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'HEA'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_D_DCFD1853_2
(ADENOSINE DEAMINASE)		 2eij CYTOCHROME C OXIDASE
SUBUNIT 1
(Bos
taurus) 		4 / 4 HIS A 291
LEU A 381
LEU A 246
LEU A 199
 CU  A 517 ( 3.1A)
HEA  A 516 (-3.6A)
None
None
 1.09A 1a4lD-2eijA:
undetectable		 1a4lD-2eijA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7B_A_HLTA4003_1
(SERUM ALBUMIN)		 3omn CYTOCHROME C
OXIDASE, AA3 TYPE,
SUBUNIT I
(Rhodobacter
sphaeroides) 		5 / 9 ILE A 432
PHE A 508
LEU A 512
GLY A  41
ALA A 114
 HEA  A   1 ( 4.6A)
HEA  A   1 (-4.6A)
None
HEA  A   1 ( 4.1A)
HEA  A   1 ( 4.0A)
 1.18A 1e7bA-3omnA:
undetectable		 1e7bA-3omnA:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQU_A_EQIA329_0
(PROTEIN (ESTRADIOL
17
BETA-DEHYDROGENASE
1))		 1qle CYTOCHROME C OXIDASE
POLYPEPTIDE I-BETA
(Paracoccus
denitrificans) 		5 / 10 VAL A 165
TYR A 267
GLY A 163
HIS A 403
ARG A 474
 None
None
HEA  A 601 (-3.6A)
MN  B 302 ( 3.2A)
HEA  A 601 ( 3.0A)
 1.33A 1equA-1qleA:
undetectable		 1equA-1qleA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQU_A_EQIA329_0
(PROTEIN (ESTRADIOL
17
BETA-DEHYDROGENASE
1))		 3omn CYTOCHROME C
OXIDASE, AA3 TYPE,
SUBUNIT I
(Rhodobacter
sphaeroides) 		5 / 10 VAL A 173
TYR A 275
GLY A 171
HIS A 411
ARG A 482
 None
None
HEA  A   1 (-3.5A)
MG  A   6 ( 3.3A)
HEA  A   1 (-3.9A)
 1.46A 1equA-3omnA:
undetectable		 1equA-3omnA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I18_A_RBFA98_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 3omn CYTOCHROME C
OXIDASE, AA3 TYPE,
SUBUNIT I
(Rhodobacter
sphaeroides) 		5 / 10 LEU A 401
ASP A 407
THR A 352
ILE A 355
PHE A 420
 HEA  A   2 (-3.8A)
HEA  A   2 (-2.5A)
HEA  A   2 (-4.2A)
None
HEA  A   2 ( 4.0A)
 1.34A 1i18A-3omnA:
undetectable
1i18B-3omnA:
undetectable		 1i18A-3omnA:
10.53
1i18B-3omnA:
10.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I18_B_RBFB99_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 3omn CYTOCHROME C
OXIDASE, AA3 TYPE,
SUBUNIT I
(Rhodobacter
sphaeroides) 		5 / 10 PHE A 420
LEU A 401
ASP A 407
THR A 352
ILE A 355
 HEA  A   2 ( 4.0A)
HEA  A   2 (-3.8A)
HEA  A   2 (-2.5A)
HEA  A   2 (-4.2A)
None
 1.35A 1i18A-3omnA:
undetectable
1i18B-3omnA:
undetectable		 1i18A-3omnA:
10.53
1i18B-3omnA:
10.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_D_SAMD200_0
(METHIONINE REPRESSOR)		 3omn CYTOCHROME C
OXIDASE, AA3 TYPE,
SUBUNIT I
(Rhodobacter
sphaeroides) 		5 / 12 HIS A 334
PHE A 281
GLY A 283
ALA A 332
HIS A 333
 CU1  A   5 (-3.1A)
None
None
None
HEA  A   2 ( 3.3A)
 1.11A 1mjqC-3omnA:
undetectable
1mjqD-3omnA:
undetectable		 1mjqC-3omnA:
10.67
1mjqD-3omnA:
10.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_J_SAMJ200_0
(METHIONINE REPRESSOR)		 3omn CYTOCHROME C
OXIDASE, AA3 TYPE,
SUBUNIT I
(Rhodobacter
sphaeroides) 		5 / 12 HIS A 334
PHE A 281
GLY A 283
ALA A 332
HIS A 333
 CU1  A   5 (-3.1A)
None
None
None
HEA  A   2 ( 3.3A)
 1.10A 1mjqI-3omnA:
undetectable
1mjqJ-3omnA:
undetectable		 1mjqI-3omnA:
10.67
1mjqJ-3omnA:
10.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJO_A_CUA701_0
(PHENYLETHYLAMINE
OXIDASE)		 3omn CYTOCHROME C
OXIDASE, AA3 TYPE,
SUBUNIT I
(Rhodobacter
sphaeroides) 		3 / 3 HIS A 333
HIS A 334
HIS A 284
 HEA  A   2 ( 3.3A)
CU1  A   5 (-3.1A)
CU1  A   5 ( 3.2A)
 0.66A 1rjoA-3omnA:
undetectable		 1rjoA-3omnA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RKY_A_CUA801_0
(LYSYL OXIDASE)		 3omn CYTOCHROME C
OXIDASE, AA3 TYPE,
SUBUNIT I
(Rhodobacter
sphaeroides) 		3 / 3 HIS A 333
HIS A 334
HIS A 284
 HEA  A   2 ( 3.3A)
CU1  A   5 (-3.1A)
CU1  A   5 ( 3.2A)
 0.67A 1rkyA-3omnA:
undetectable		 1rkyA-3omnA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S14_B_NOVB2300_1
(TOPOISOMERASE IV
SUBUNIT B)		 2eij CYTOCHROME C OXIDASE
SUBUNIT 1
(Bos
taurus) 		5 / 12 SER A 361
ASP A 364
MET A 310
ALA A 313
ILE A 356
 None
HEA  A 516 (-2.7A)
None
HEA  A 516 ( 3.8A)
HEA  A 516 (-4.4A)
 1.38A 1s14B-2eijA:
undetectable		 1s14B-2eijA:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UOB_A_PNNA1311_1
(DEACETOXYCEPHALOSPOR
IN C SYNTHETASE)		 2eij CYTOCHROME C OXIDASE
SUBUNIT 1
(Bos
taurus) 		3 / 3 ARG A 439
ARG A 438
ILE A  37
 HEA  A 515 (-3.8A)
HEA  A 516 ( 3.1A)
HEA  A 515 (-4.2A)
 0.79A 1uobA-2eijA:
undetectable		 1uobA-2eijA:
20.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1V54_A_CUA517_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I)		 3omn CYTOCHROME C
OXIDASE, AA3 TYPE,
SUBUNIT I
(Rhodobacter
sphaeroides) 		3 / 3 HIS A 284
HIS A 333
HIS A 334
 CU1  A   5 ( 3.2A)
HEA  A   2 ( 3.3A)
CU1  A   5 (-3.1A)
 0.16A 1v54A-3omnA:
57.8		 1v54A-3omnA:
51.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1V54_N_CUN517_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I)		 3omn CYTOCHROME C
OXIDASE, AA3 TYPE,
SUBUNIT I
(Rhodobacter
sphaeroides) 		3 / 3 HIS A 284
HIS A 333
HIS A 334
 CU1  A   5 ( 3.2A)
HEA  A   2 ( 3.3A)
CU1  A   5 (-3.1A)
 0.20A 1v54N-3omnA:
57.8		 1v54N-3omnA:
51.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1V55_A_CUA517_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I)		 3omn CYTOCHROME C
OXIDASE, AA3 TYPE,
SUBUNIT I
(Rhodobacter
sphaeroides) 		3 / 3 HIS A 284
HIS A 333
HIS A 334
 CU1  A   5 ( 3.2A)
HEA  A   2 ( 3.3A)
CU1  A   5 (-3.1A)
 0.16A 1v55A-3omnA:
57.6		 1v55A-3omnA:
51.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1V55_N_CUN517_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I)		 3omn CYTOCHROME C
OXIDASE, AA3 TYPE,
SUBUNIT I
(Rhodobacter
sphaeroides) 		3 / 3 HIS A 284
HIS A 333
HIS A 334
 CU1  A   5 ( 3.2A)
HEA  A   2 ( 3.3A)
CU1  A   5 (-3.1A)
 0.14A 1v55N-3omnA:
57.5		 1v55N-3omnA:
51.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W2Z_A_CUA701_0
(AMINE OXIDASE,
COPPER CONTAINING)		 3omn CYTOCHROME C
OXIDASE, AA3 TYPE,
SUBUNIT I
(Rhodobacter
sphaeroides) 		3 / 3 HIS A 333
HIS A 334
HIS A 284
 HEA  A   2 ( 3.3A)
CU1  A   5 (-3.1A)
CU1  A   5 ( 3.2A)
 0.72A 1w2zA-3omnA:
undetectable		 1w2zA-3omnA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W2Z_B_CUB701_0
(AMINE OXIDASE,
COPPER CONTAINING)		 3omn CYTOCHROME C
OXIDASE, AA3 TYPE,
SUBUNIT I
(Rhodobacter
sphaeroides) 		3 / 3 HIS A 333
HIS A 334
HIS A 284
 HEA  A   2 ( 3.3A)
CU1  A   5 (-3.1A)
CU1  A   5 ( 3.2A)
 0.71A 1w2zB-3omnA:
undetectable		 1w2zB-3omnA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W2Z_C_CUC701_0
(AMINE OXIDASE,
COPPER CONTAINING)		 3omn CYTOCHROME C
OXIDASE, AA3 TYPE,
SUBUNIT I
(Rhodobacter
sphaeroides) 		3 / 3 HIS A 333
HIS A 334
HIS A 284
 HEA  A   2 ( 3.3A)
CU1  A   5 (-3.1A)
CU1  A   5 ( 3.2A)
 0.70A 1w2zC-3omnA:
undetectable		 1w2zC-3omnA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W2Z_D_CUD701_0
(AMINE OXIDASE,
COPPER CONTAINING)		 3omn CYTOCHROME C
OXIDASE, AA3 TYPE,
SUBUNIT I
(Rhodobacter
sphaeroides) 		3 / 3 HIS A 333
HIS A 334
HIS A 284
 HEA  A   2 ( 3.3A)
CU1  A   5 (-3.1A)
CU1  A   5 ( 3.2A)
 0.69A 1w2zD-3omnA:
undetectable		 1w2zD-3omnA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y0X_X_T44X500_1
(THYROID HORMONE
RECEPTOR BETA-1)		 1qle CYTOCHROME C OXIDASE
POLYPEPTIDE I-BETA
(Paracoccus
denitrificans) 		5 / 12 ILE A 424
ALA A 106
MET A 452
PHE A 425
PHE A 503
 None
HEA  A 601 (-3.3A)
HEA  A 601 (-4.1A)
None
None
 1.20A 1y0xX-1qleA:
undetectable		 1y0xX-1qleA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y0X_X_T44X500_1
(THYROID HORMONE
RECEPTOR BETA-1)		 3omn CYTOCHROME C
OXIDASE, AA3 TYPE,
SUBUNIT I
(Rhodobacter
sphaeroides) 		5 / 12 ILE A 432
ALA A 114
MET A 460
PHE A 433
PHE A 511
 HEA  A   1 ( 4.6A)
HEA  A   1 ( 4.0A)
HEA  A   1 (-4.0A)
None
HEA  A   1 ( 4.9A)
 1.15A 1y0xX-3omnA:
undetectable		 1y0xX-3omnA:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2D0K_A_FOLA1161_0
(DIHYDROFOLATE
REDUCTASE)		 2eij CYTOCHROME C OXIDASE
SUBUNIT 1
(Bos
taurus) 		5 / 12 ILE A 312
ILE A 190
LEU A 248
PRO A 249
ILE A 280
 HEA  A 516 (-3.9A)
None
None
None
None
 0.95A 2d0kA-2eijA:
undetectable		 2d0kA-2eijA:
15.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2DYR_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3omn CYTOCHROME C
OXIDASE, AA3 TYPE,
SUBUNIT I
(Rhodobacter
sphaeroides) 		3 / 3 HIS A 284
HIS A 333
HIS A 334
 CU1  A   5 ( 3.2A)
HEA  A   2 ( 3.3A)
CU1  A   5 (-3.1A)
 0.14A 2dyrA-3omnA:
57.9		 2dyrA-3omnA:
51.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2DYR_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3omn CYTOCHROME C
OXIDASE, AA3 TYPE,
SUBUNIT I
(Rhodobacter
sphaeroides) 		3 / 3 HIS A 284
HIS A 333
HIS A 334
 CU1  A   5 ( 3.2A)
HEA  A   2 ( 3.3A)
CU1  A   5 (-3.1A)
 0.20A 2dyrN-3omnA:
57.8		 2dyrN-3omnA:
51.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2DYS_A_CUA601_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3omn CYTOCHROME C
OXIDASE, AA3 TYPE,
SUBUNIT I
(Rhodobacter
sphaeroides) 		3 / 3 HIS A 284
HIS A 333
HIS A 334
 CU1  A   5 ( 3.2A)
HEA  A   2 ( 3.3A)
CU1  A   5 (-3.1A)
 0.22A 2dysA-3omnA:
57.9		 2dysA-3omnA:
51.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2DYS_N_CUN601_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3omn CYTOCHROME C
OXIDASE, AA3 TYPE,
SUBUNIT I
(Rhodobacter
sphaeroides) 		3 / 3 HIS A 284
HIS A 333
HIS A 334
 CU1  A   5 ( 3.2A)
HEA  A   2 ( 3.3A)
CU1  A   5 (-3.1A)
 0.24A 2dysN-3omnA:
57.8		 2dysN-3omnA:
51.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2EIJ_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3omn CYTOCHROME C
OXIDASE, AA3 TYPE,
SUBUNIT I
(Rhodobacter
sphaeroides) 		3 / 3 HIS A 284
HIS A 333
HIS A 334
 CU1  A   5 ( 3.2A)
HEA  A   2 ( 3.3A)
CU1  A   5 (-3.1A)
 0.09A 2eijA-3omnA:
57.6		 2eijA-3omnA:
51.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2EIJ_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3omn CYTOCHROME C
OXIDASE, AA3 TYPE,
SUBUNIT I
(Rhodobacter
sphaeroides) 		3 / 3 HIS A 284
HIS A 333
HIS A 334
 CU1  A   5 ( 3.2A)
HEA  A   2 ( 3.3A)
CU1  A   5 (-3.1A)
 0.14A 2eijN-3omnA:
57.5		 2eijN-3omnA:
51.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2EIK_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3omn CYTOCHROME C
OXIDASE, AA3 TYPE,
SUBUNIT I
(Rhodobacter
sphaeroides) 		3 / 3 HIS A 284
HIS A 333
HIS A 334
 CU1  A   5 ( 3.2A)
HEA  A   2 ( 3.3A)
CU1  A   5 (-3.1A)
 0.00A 2eikA-3omnA:
57.6		 2eikA-3omnA:
51.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2EIK_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3omn CYTOCHROME C
OXIDASE, AA3 TYPE,
SUBUNIT I
(Rhodobacter
sphaeroides) 		3 / 3 HIS A 284
HIS A 333
HIS A 334
 CU1  A   5 ( 3.2A)
HEA  A   2 ( 3.3A)
CU1  A   5 (-3.1A)
 0.21A 2eikN-3omnA:
57.6		 2eikN-3omnA:
51.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2EIL_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3omn CYTOCHROME C
OXIDASE, AA3 TYPE,
SUBUNIT I
(Rhodobacter
sphaeroides) 		3 / 3 HIS A 284
HIS A 333
HIS A 334
 CU1  A   5 ( 3.2A)
HEA  A   2 ( 3.3A)
CU1  A   5 (-3.1A)
 0.16A 2eilA-3omnA:
57.8		 2eilA-3omnA:
51.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2EIL_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3omn CYTOCHROME C
OXIDASE, AA3 TYPE,
SUBUNIT I
(Rhodobacter
sphaeroides) 		3 / 3 HIS A 284
HIS A 333
HIS A 334
 CU1  A   5 ( 3.2A)
HEA  A   2 ( 3.3A)
CU1  A   5 (-3.1A)
 0.23A 2eilN-3omnA:
57.9		 2eilN-3omnA:
51.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2EIM_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3omn CYTOCHROME C
OXIDASE, AA3 TYPE,
SUBUNIT I
(Rhodobacter
sphaeroides) 		3 / 3 HIS A 284
HIS A 333
HIS A 334
 CU1  A   5 ( 3.2A)
HEA  A   2 ( 3.3A)
CU1  A   5 (-3.1A)
 0.19A 2eimA-3omnA:
57.4		 2eimA-3omnA:
51.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2EIM_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3omn CYTOCHROME C
OXIDASE, AA3 TYPE,
SUBUNIT I
(Rhodobacter
sphaeroides) 		3 / 3 HIS A 284
HIS A 333
HIS A 334
 CU1  A   5 ( 3.2A)
HEA  A   2 ( 3.3A)
CU1  A   5 (-3.1A)
 0.23A 2eimN-3omnA:
57.3		 2eimN-3omnA:
51.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2EIN_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3omn CYTOCHROME C
OXIDASE, AA3 TYPE,
SUBUNIT I
(Rhodobacter
sphaeroides) 		3 / 3 HIS A 284
HIS A 333
HIS A 334
 CU1  A   5 ( 3.2A)
HEA  A   2 ( 3.3A)
CU1  A   5 (-3.1A)
 0.22A 2einA-3omnA:
57.6		 2einA-3omnA:
51.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2EIN_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3omn CYTOCHROME C
OXIDASE, AA3 TYPE,
SUBUNIT I
(Rhodobacter
sphaeroides) 		3 / 3 HIS A 284
HIS A 333
HIS A 334
 CU1  A   5 ( 3.2A)
HEA  A   2 ( 3.3A)
CU1  A   5 (-3.1A)
 0.34A 2einN-3omnA:
57.6		 2einN-3omnA:
51.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FK8_A_SAMA302_0
(METHOXY MYCOLIC ACID
SYNTHASE 4)		 2eij CYTOCHROME C OXIDASE
SUBUNIT 1
(Bos
taurus) 		5 / 12 ILE A  75
GLY A  76
GLY A  16
GLY A 160
ILE A  73
 None
None
None
None
HEA  A 515 (-4.4A)
 0.70A 2fk8A-2eijA:
undetectable		 2fk8A-2eijA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNI_A_MTKA501_2
(CYTOCHROME P450 2C8)		 3omn CYTOCHROME C
OXIDASE, AA3 TYPE,
SUBUNIT I
(Rhodobacter
sphaeroides) 		4 / 8 ILE A 290
ILE A 289
ILE A 232
ALA A 205
 HEA  A   2 ( 4.5A)
None
None
None
 0.70A 2nniA-3omnA:
0.5		 2nniA-3omnA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OQE_A_CUA801_0
(PEROXISOMAL COPPER
AMINE OXIDASE)		 3omn CYTOCHROME C
OXIDASE, AA3 TYPE,
SUBUNIT I
(Rhodobacter
sphaeroides) 		3 / 3 HIS A 333
HIS A 334
HIS A 284
 HEA  A   2 ( 3.3A)
CU1  A   5 (-3.1A)
CU1  A   5 ( 3.2A)
 0.66A 2oqeA-3omnA:
undetectable		 2oqeA-3omnA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OQE_B_CUB801_0
(PEROXISOMAL COPPER
AMINE OXIDASE)		 3omn CYTOCHROME C
OXIDASE, AA3 TYPE,
SUBUNIT I
(Rhodobacter
sphaeroides) 		3 / 3 HIS A 333
HIS A 334
HIS A 284
 HEA  A   2 ( 3.3A)
CU1  A   5 (-3.1A)
CU1  A   5 ( 3.2A)
 0.65A 2oqeB-3omnA:
undetectable		 2oqeB-3omnA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OQE_C_CUC801_0
(PEROXISOMAL COPPER
AMINE OXIDASE)		 3omn CYTOCHROME C
OXIDASE, AA3 TYPE,
SUBUNIT I
(Rhodobacter
sphaeroides) 		3 / 3 HIS A 333
HIS A 334
HIS A 284
 HEA  A   2 ( 3.3A)
CU1  A   5 (-3.1A)
CU1  A   5 ( 3.2A)
 0.66A 2oqeC-3omnA:
undetectable		 2oqeC-3omnA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OQE_D_CUD801_0
(PEROXISOMAL COPPER
AMINE OXIDASE)		 3omn CYTOCHROME C
OXIDASE, AA3 TYPE,
SUBUNIT I
(Rhodobacter
sphaeroides) 		3 / 3 HIS A 333
HIS A 334
HIS A 284
 HEA  A   2 ( 3.3A)
CU1  A   5 (-3.1A)
CU1  A   5 ( 3.2A)
 0.63A 2oqeD-3omnA:
undetectable		 2oqeD-3omnA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OQE_F_CUF801_0
(PEROXISOMAL COPPER
AMINE OXIDASE)		 3omn CYTOCHROME C
OXIDASE, AA3 TYPE,
SUBUNIT I
(Rhodobacter
sphaeroides) 		3 / 3 HIS A 333
HIS A 334
HIS A 284
 HEA  A   2 ( 3.3A)
CU1  A   5 (-3.1A)
CU1  A   5 ( 3.2A)
 0.65A 2oqeF-3omnA:
undetectable		 2oqeF-3omnA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QX4_A_ML1A233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 2eij CYTOCHROME C OXIDASE
SUBUNIT 1
(Bos
taurus) 		4 / 8 PHE A 348
ILE A 247
PHE A 344
GLY A 252
 None
HEA  A 516 (-3.6A)
None
None
 0.91A 2qx4A-2eijA:
undetectable
2qx4B-2eijA:
undetectable		 2qx4A-2eijA:
16.90
2qx4B-2eijA:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W0Q_A_CUA801_0
(COPPER AMINE OXIDASE)		 3omn CYTOCHROME C
OXIDASE, AA3 TYPE,
SUBUNIT I
(Rhodobacter
sphaeroides) 		3 / 3 HIS A 333
HIS A 334
HIS A 284
 HEA  A   2 ( 3.3A)
CU1  A   5 (-3.1A)
CU1  A   5 ( 3.2A)
 0.67A 2w0qA-3omnA:
undetectable		 2w0qA-3omnA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W0Q_B_CUB801_0
(COPPER AMINE OXIDASE)		 3omn CYTOCHROME C
OXIDASE, AA3 TYPE,
SUBUNIT I
(Rhodobacter
sphaeroides) 		3 / 3 HIS A 333
HIS A 334
HIS A 284
 HEA  A   2 ( 3.3A)
CU1  A   5 (-3.1A)
CU1  A   5 ( 3.2A)
 0.68A 2w0qB-3omnA:
undetectable		 2w0qB-3omnA:
21.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2Y69_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3omn CYTOCHROME C
OXIDASE, AA3 TYPE,
SUBUNIT I
(Rhodobacter
sphaeroides) 		3 / 3 HIS A 284
HIS A 333
HIS A 334
 CU1  A   5 ( 3.2A)
HEA  A   2 ( 3.3A)
CU1  A   5 (-3.1A)
 0.14A 2y69A-3omnA:
58.0		 2y69A-3omnA:
51.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2Y69_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3omn CYTOCHROME C
OXIDASE, AA3 TYPE,
SUBUNIT I
(Rhodobacter
sphaeroides) 		3 / 3 HIS A 284
HIS A 333
HIS A 334
 CU1  A   5 ( 3.2A)
HEA  A   2 ( 3.3A)
CU1  A   5 (-3.1A)
 0.11A 2y69N-3omnA:
57.9		 2y69N-3omnA:
51.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7P_A_SALA1001_1
(LYSR-TYPE REGULATORY
PROTEIN)		 1qle CYTOCHROME C OXIDASE
POLYPEPTIDE I-BETA
CYTOCHROME C OXIDASE
POLYPEPTIDE II
(Paracoccus
denitrificans) 		4 / 6 MET A 308
PRO A 350
GLY A 352
TRP B  81
 None
None
HEA  A 602 ( 3.7A)
None
 1.17A 2y7pA-1qleA:
undetectable		 2y7pA-1qleA:
18.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ZXW_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3omn CYTOCHROME C
OXIDASE, AA3 TYPE,
SUBUNIT I
(Rhodobacter
sphaeroides) 		3 / 3 HIS A 284
HIS A 333
HIS A 334
 CU1  A   5 ( 3.2A)
HEA  A   2 ( 3.3A)
CU1  A   5 (-3.1A)
 0.25A 2zxwA-3omnA:
57.7		 2zxwA-3omnA:
51.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ZXW_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3omn CYTOCHROME C
OXIDASE, AA3 TYPE,
SUBUNIT I
(Rhodobacter
sphaeroides) 		3 / 3 HIS A 284
HIS A 333
HIS A 334
 CU1  A   5 ( 3.2A)
HEA  A   2 ( 3.3A)
CU1  A   5 (-3.1A)
 0.22A 2zxwN-3omnA:
57.7		 2zxwN-3omnA:
51.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ABK_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3omn CYTOCHROME C
OXIDASE, AA3 TYPE,
SUBUNIT I
(Rhodobacter
sphaeroides) 		3 / 3 HIS A 284
HIS A 333
HIS A 334
 CU1  A   5 ( 3.2A)
HEA  A   2 ( 3.3A)
CU1  A   5 (-3.1A)
 0.21A 3abkA-3omnA:
57.5		 3abkA-3omnA:
51.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ABK_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3omn CYTOCHROME C
OXIDASE, AA3 TYPE,
SUBUNIT I
(Rhodobacter
sphaeroides) 		3 / 3 HIS A 284
HIS A 333
HIS A 334
 CU1  A   5 ( 3.2A)
HEA  A   2 ( 3.3A)
CU1  A   5 (-3.1A)
 0.13A 3abkN-3omnA:
57.5		 3abkN-3omnA:
51.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ABL_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3omn CYTOCHROME C
OXIDASE, AA3 TYPE,
SUBUNIT I
(Rhodobacter
sphaeroides) 		3 / 3 HIS A 284
HIS A 333
HIS A 334
 CU1  A   5 ( 3.2A)
HEA  A   2 ( 3.3A)
CU1  A   5 (-3.1A)
 0.24A 3ablA-3omnA:
57.7		 3ablA-3omnA:
51.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ABL_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3omn CYTOCHROME C
OXIDASE, AA3 TYPE,
SUBUNIT I
(Rhodobacter
sphaeroides) 		3 / 3 HIS A 284
HIS A 333
HIS A 334
 CU1  A   5 ( 3.2A)
HEA  A   2 ( 3.3A)
CU1  A   5 (-3.1A)
 0.29A 3ablN-3omnA:
57.7		 3ablN-3omnA:
51.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ABM_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3omn CYTOCHROME C
OXIDASE, AA3 TYPE,
SUBUNIT I
(Rhodobacter
sphaeroides) 		3 / 3 HIS A 284
HIS A 333
HIS A 334
 CU1  A   5 ( 3.2A)
HEA  A   2 ( 3.3A)
CU1  A   5 (-3.1A)
 0.18A 3abmA-3omnA:
57.8		 3abmA-3omnA:
51.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ABM_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3omn CYTOCHROME C
OXIDASE, AA3 TYPE,
SUBUNIT I
(Rhodobacter
sphaeroides) 		3 / 3 HIS A 284
HIS A 333
HIS A 334
 CU1  A   5 ( 3.2A)
HEA  A   2 ( 3.3A)
CU1  A   5 (-3.1A)
 0.14A 3abmN-3omnA:
57.8		 3abmN-3omnA:
51.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3AG1_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3omn CYTOCHROME C
OXIDASE, AA3 TYPE,
SUBUNIT I
(Rhodobacter
sphaeroides) 		3 / 3 HIS A 284
HIS A 333
HIS A 334
 CU1  A   5 ( 3.2A)
HEA  A   2 ( 3.3A)
CU1  A   5 (-3.1A)
 0.08A 3ag1A-3omnA:
57.2		 3ag1A-3omnA:
51.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3AG1_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3omn CYTOCHROME C
OXIDASE, AA3 TYPE,
SUBUNIT I
(Rhodobacter
sphaeroides) 		3 / 3 HIS A 284
HIS A 333
HIS A 334
 CU1  A   5 ( 3.2A)
HEA  A   2 ( 3.3A)
CU1  A   5 (-3.1A)
 0.08A 3ag1N-3omnA:
57.1		 3ag1N-3omnA:
51.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3AG2_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3omn CYTOCHROME C
OXIDASE, AA3 TYPE,
SUBUNIT I
(Rhodobacter
sphaeroides) 		3 / 3 HIS A 284
HIS A 333
HIS A 334
 CU1  A   5 ( 3.2A)
HEA  A   2 ( 3.3A)
CU1  A   5 (-3.1A)
 0.14A 3ag2A-3omnA:
57.6		 3ag2A-3omnA:
51.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3AG2_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3omn CYTOCHROME C
OXIDASE, AA3 TYPE,
SUBUNIT I
(Rhodobacter
sphaeroides) 		3 / 3 HIS A 284
HIS A 333
HIS A 334
 CU1  A   5 ( 3.2A)
HEA  A   2 ( 3.3A)
CU1  A   5 (-3.1A)
 0.20A 3ag2N-3omnA:
57.7		 3ag2N-3omnA:
51.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3AG3_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3omn CYTOCHROME C
OXIDASE, AA3 TYPE,
SUBUNIT I
(Rhodobacter
sphaeroides) 		3 / 3 HIS A 284
HIS A 333
HIS A 334
 CU1  A   5 ( 3.2A)
HEA  A   2 ( 3.3A)
CU1  A   5 (-3.1A)
 0.14A 3ag3A-3omnA:
57.5		 3ag3A-3omnA:
51.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3AG3_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3omn CYTOCHROME C
OXIDASE, AA3 TYPE,
SUBUNIT I
(Rhodobacter
sphaeroides) 		3 / 3 HIS A 284
HIS A 333
HIS A 334
 CU1  A   5 ( 3.2A)
HEA  A   2 ( 3.3A)
CU1  A   5 (-3.1A)
 0.15A 3ag3N-3omnA:
57.5		 3ag3N-3omnA:
51.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3AG4_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3omn CYTOCHROME C
OXIDASE, AA3 TYPE,
SUBUNIT I
(Rhodobacter
sphaeroides) 		3 / 3 HIS A 284
HIS A 333
HIS A 334
 CU1  A   5 ( 3.2A)
HEA  A   2 ( 3.3A)
CU1  A   5 (-3.1A)
 0.17A 3ag4A-3omnA:
57.4		 3ag4A-3omnA:
51.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3AG4_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3omn CYTOCHROME C
OXIDASE, AA3 TYPE,
SUBUNIT I
(Rhodobacter
sphaeroides) 		3 / 3 HIS A 284
HIS A 333
HIS A 334
 CU1  A   5 ( 3.2A)
HEA  A   2 ( 3.3A)
CU1  A   5 (-3.1A)
 0.05A 3ag4N-3omnA:
57.4		 3ag4N-3omnA:
51.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ASN_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3omn CYTOCHROME C
OXIDASE, AA3 TYPE,
SUBUNIT I
(Rhodobacter
sphaeroides) 		3 / 3 HIS A 284
HIS A 333
HIS A 334
 CU1  A   5 ( 3.2A)
HEA  A   2 ( 3.3A)
CU1  A   5 (-3.1A)
 0.00A 3asnA-3omnA:
58.0		 3asnA-3omnA:
51.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ASN_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3omn CYTOCHROME C
OXIDASE, AA3 TYPE,
SUBUNIT I
(Rhodobacter
sphaeroides) 		3 / 3 HIS A 284
HIS A 333
HIS A 334
 CU1  A   5 ( 3.2A)
HEA  A   2 ( 3.3A)
CU1  A   5 (-3.1A)
 0.17A 3asnN-3omnA:
57.9		 3asnN-3omnA:
51.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ASO_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3omn CYTOCHROME C
OXIDASE, AA3 TYPE,
SUBUNIT I
(Rhodobacter
sphaeroides) 		3 / 3 HIS A 284
HIS A 333
HIS A 334
 CU1  A   5 ( 3.2A)
HEA  A   2 ( 3.3A)
CU1  A   5 (-3.1A)
 0.00A 3asoA-3omnA:
57.9		 3asoA-3omnA:
51.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ASO_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3omn CYTOCHROME C
OXIDASE, AA3 TYPE,
SUBUNIT I
(Rhodobacter
sphaeroides) 		3 / 3 HIS A 284
HIS A 333
HIS A 334
 CU1  A   5 ( 3.2A)
HEA  A   2 ( 3.3A)
CU1  A   5 (-3.1A)
 0.14A 3asoN-3omnA:
57.9		 3asoN-3omnA:
51.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BVD_A_CUA803_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3omn CYTOCHROME C
OXIDASE, AA3 TYPE,
SUBUNIT I
(Rhodobacter
sphaeroides) 		3 / 3 HIS A 284
HIS A 333
HIS A 334
 CU1  A   5 ( 3.2A)
HEA  A   2 ( 3.3A)
CU1  A   5 (-3.1A)
 0.52A 3bvdA-3omnA:
36.6		 3bvdA-3omnA:
26.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DLC_A_SAMA220_0
(PUTATIVE
S-ADENOSYL-L-METHION
INE-DEPENDENT
METHYLTRANSFERASE)		 3omn CYTOCHROME C
OXIDASE, AA3 TYPE,
SUBUNIT I
(Rhodobacter
sphaeroides) 		5 / 12 PHE A 295
GLY A 427
GLY A 431
PHE A 391
HIS A 419
 None
None
None
HEA  A   2 (-4.5A)
HEA  A   2 (-3.2A)
 1.30A 3dlcA-3omnA:
undetectable		 3dlcA-3omnA:
16.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3DTU_A_CUA1023_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3omn CYTOCHROME C
OXIDASE, AA3 TYPE,
SUBUNIT I
(Rhodobacter
sphaeroides) 		3 / 3 HIS A 284
HIS A 333
HIS A 334
 CU1  A   5 ( 3.2A)
HEA  A   2 ( 3.3A)
CU1  A   5 (-3.1A)
 0.12A 3dtuA-3omnA:
65.9		 3dtuA-3omnA:
99.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3DTU_C_CUC569_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3omn CYTOCHROME C
OXIDASE, AA3 TYPE,
SUBUNIT I
(Rhodobacter
sphaeroides) 		3 / 3 HIS A 284
HIS A 333
HIS A 334
 CU1  A   5 ( 3.2A)
HEA  A   2 ( 3.3A)
CU1  A   5 (-3.1A)
 0.11A 3dtuC-3omnA:
66.2		 3dtuC-3omnA:
99.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HII_A_CUA801_0
(AMILORIDE-SENSITIVE
AMINE OXIDASE)		 3omn CYTOCHROME C
OXIDASE, AA3 TYPE,
SUBUNIT I
(Rhodobacter
sphaeroides) 		3 / 3 HIS A 333
HIS A 334
HIS A 284
 HEA  A   2 ( 3.3A)
CU1  A   5 (-3.1A)
CU1  A   5 ( 3.2A)
 0.61A 3hiiA-3omnA:
undetectable		 3hiiA-3omnA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HII_B_CUB801_0
(AMILORIDE-SENSITIVE
AMINE OXIDASE)		 3omn CYTOCHROME C
OXIDASE, AA3 TYPE,
SUBUNIT I
(Rhodobacter
sphaeroides) 		3 / 3 HIS A 333
HIS A 334
HIS A 284
 HEA  A   2 ( 3.3A)
CU1  A   5 (-3.1A)
CU1  A   5 ( 3.2A)
 0.60A 3hiiB-3omnA:
undetectable		 3hiiB-3omnA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_A_TFPA201_1
(PROTEIN S100-A4)		 3omn CYTOCHROME C
OXIDASE, AA3 TYPE,
SUBUNIT I
(Rhodobacter
sphaeroides) 		5 / 9 GLY A 103
ILE A 290
PHE A 430
PHE A 433
GLY A  41
 HEA  A   1 ( 3.8A)
HEA  A   2 ( 4.5A)
None
None
HEA  A   1 ( 4.1A)
 1.36A 3ko0A-3omnA:
undetectable
3ko0C-3omnA:
0.1		 3ko0A-3omnA:
11.48
3ko0C-3omnA:
11.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_B_TFPB201_1
(PROTEIN S100-A4)		 1qle CYTOCHROME C OXIDASE
POLYPEPTIDE I-BETA
(Paracoccus
denitrificans) 		4 / 8 GLY A  95
ILE A 282
PHE A 422
PHE A 425
 HEA  A 601 ( 4.0A)
HEA  A 602 ( 4.7A)
None
None
 1.03A 3ko0B-1qleA:
undetectable
3ko0J-1qleA:
undetectable		 3ko0B-1qleA:
10.65
3ko0J-1qleA:
10.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_G_TFPG201_1
(PROTEIN S100-A4)		 1qle CYTOCHROME C OXIDASE
POLYPEPTIDE I-BETA
(Paracoccus
denitrificans) 		5 / 9 GLY A  43
GLY A  95
ILE A 282
PHE A 422
PHE A 425
 HEA  A 601 ( 4.1A)
HEA  A 601 ( 4.0A)
HEA  A 602 ( 4.7A)
None
None
 1.21A 3ko0F-1qleA:
undetectable
3ko0G-1qleA:
undetectable		 3ko0F-1qleA:
10.65
3ko0G-1qleA:
10.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_I_TFPI201_1
(PROTEIN S100-A4)		 1qle CYTOCHROME C OXIDASE
POLYPEPTIDE I-BETA
(Paracoccus
denitrificans) 		5 / 9 GLY A  43
GLY A  95
ILE A 282
PHE A 422
PHE A 425
 HEA  A 601 ( 4.1A)
HEA  A 601 ( 4.0A)
HEA  A 602 ( 4.7A)
None
None
 1.13A 3ko0H-1qleA:
undetectable
3ko0I-1qleA:
undetectable		 3ko0H-1qleA:
10.65
3ko0I-1qleA:
10.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_I_TFPI201_1
(PROTEIN S100-A4)		 3omn CYTOCHROME C
OXIDASE, AA3 TYPE,
SUBUNIT I
(Rhodobacter
sphaeroides) 		5 / 9 GLY A  41
GLY A 103
ILE A 290
PHE A 430
PHE A 433
 HEA  A   1 ( 4.1A)
HEA  A   1 ( 3.8A)
HEA  A   2 ( 4.5A)
None
None
 1.28A 3ko0H-3omnA:
undetectable
3ko0I-3omnA:
undetectable		 3ko0H-3omnA:
11.48
3ko0I-3omnA:
11.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_K_TFPK201_1
(PROTEIN S100-A4)		 1qle CYTOCHROME C OXIDASE
POLYPEPTIDE I-BETA
(Paracoccus
denitrificans) 		4 / 8 GLY A  95
ILE A 282
PHE A 422
PHE A 425
 HEA  A 601 ( 4.0A)
HEA  A 602 ( 4.7A)
None
None
 1.05A 3ko0K-1qleA:
undetectable
3ko0S-1qleA:
undetectable		 3ko0K-1qleA:
10.65
3ko0S-1qleA:
10.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_N_TFPN201_1
(PROTEIN S100-A4)		 1qle CYTOCHROME C OXIDASE
POLYPEPTIDE I-BETA
(Paracoccus
denitrificans) 		5 / 10 GLY A  43
GLY A  95
ILE A 282
PHE A 422
PHE A 425
 HEA  A 601 ( 4.1A)
HEA  A 601 ( 4.0A)
HEA  A 602 ( 4.7A)
None
None
 1.13A 3ko0L-1qleA:
undetectable
3ko0N-1qleA:
undetectable		 3ko0L-1qleA:
10.65
3ko0N-1qleA:
10.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_N_TFPN201_1
(PROTEIN S100-A4)		 3omn CYTOCHROME C
OXIDASE, AA3 TYPE,
SUBUNIT I
(Rhodobacter
sphaeroides) 		5 / 10 GLY A  41
GLY A 103
ILE A 290
PHE A 430
PHE A 433
 HEA  A   1 ( 4.1A)
HEA  A   1 ( 3.8A)
HEA  A   2 ( 4.5A)
None
None
 1.29A 3ko0L-3omnA:
undetectable
3ko0N-3omnA:
0.1		 3ko0L-3omnA:
11.48
3ko0N-3omnA:
11.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_O_TFPO201_1
(PROTEIN S100-A4)		 1qle CYTOCHROME C OXIDASE
POLYPEPTIDE I-BETA
(Paracoccus
denitrificans) 		4 / 8 GLY A 387
PHE A 449
GLY A 419
PHE A 422
 HEA  A 602 (-3.3A)
None
None
None
 0.64A 3ko0O-1qleA:
undetectable
3ko0Q-1qleA:
0.1		 3ko0O-1qleA:
10.65
3ko0Q-1qleA:
10.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_R_TFPR201_1
(PROTEIN S100-A4)		 1qle CYTOCHROME C OXIDASE
POLYPEPTIDE I-BETA
(Paracoccus
denitrificans) 		5 / 10 GLY A  95
ILE A 282
PHE A 422
PHE A 425
GLY A  43
 HEA  A 601 ( 4.0A)
HEA  A 602 ( 4.7A)
None
None
HEA  A 601 ( 4.1A)
 1.21A 3ko0R-1qleA:
undetectable
3ko0T-1qleA:
undetectable		 3ko0R-1qleA:
10.65
3ko0T-1qleA:
10.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_R_TFPR201_1
(PROTEIN S100-A4)		 3omn CYTOCHROME C
OXIDASE, AA3 TYPE,
SUBUNIT I
(Rhodobacter
sphaeroides) 		5 / 10 GLY A 103
ILE A 290
PHE A 430
PHE A 433
GLY A  41
 HEA  A   1 ( 3.8A)
HEA  A   2 ( 4.5A)
None
None
HEA  A   1 ( 4.1A)
 1.34A 3ko0R-3omnA:
0.0
3ko0T-3omnA:
undetectable		 3ko0R-3omnA:
11.48
3ko0T-3omnA:
11.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P4W_B_DSFB319_1
(GLR4197 PROTEIN)		 1qle CYTOCHROME C OXIDASE
POLYPEPTIDE I-BETA
(Paracoccus
denitrificans) 		5 / 9 PRO A 285
ILE A 104
ILE A 282
THR A 227
ILE A 231
 None
None
HEA  A 602 ( 4.7A)
None
None
 1.16A 3p4wB-1qleA:
2.4		 3p4wB-1qleA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P4W_D_DSFD319_1
(GLR4197 PROTEIN)		 1qle CYTOCHROME C OXIDASE
POLYPEPTIDE I-BETA
(Paracoccus
denitrificans) 		5 / 10 PRO A 285
ILE A 104
ILE A 282
THR A 227
ILE A 231
 None
None
HEA  A 602 ( 4.7A)
None
None
 1.16A 3p4wD-1qleA:
undetectable		 3p4wD-1qleA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P4W_E_DSFE319_1
(GLR4197 PROTEIN)		 1qle CYTOCHROME C OXIDASE
POLYPEPTIDE I-BETA
(Paracoccus
denitrificans) 		5 / 10 PRO A 285
ILE A 104
ILE A 282
THR A 227
ILE A 231
 None
None
HEA  A 602 ( 4.7A)
None
None
 1.15A 3p4wE-1qleA:
2.0		 3p4wE-1qleA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S33_A_CUA803_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3omn CYTOCHROME C
OXIDASE, AA3 TYPE,
SUBUNIT I
(Rhodobacter
sphaeroides) 		3 / 3 HIS A 284
HIS A 333
HIS A 334
 CU1  A   5 ( 3.2A)
HEA  A   2 ( 3.3A)
CU1  A   5 (-3.1A)
 0.43A 3s33A-3omnA:
36.5		 3s33A-3omnA:
26.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S38_A_CUA803_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3omn CYTOCHROME C
OXIDASE, AA3 TYPE,
SUBUNIT I
(Rhodobacter
sphaeroides) 		3 / 3 HIS A 284
HIS A 333
HIS A 334
 CU1  A   5 ( 3.2A)
HEA  A   2 ( 3.3A)
CU1  A   5 (-3.1A)
 0.54A 3s38A-3omnA:
36.4		 3s38A-3omnA:
26.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S39_A_CUA803_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3omn CYTOCHROME C
OXIDASE, AA3 TYPE,
SUBUNIT I
(Rhodobacter
sphaeroides) 		3 / 3 HIS A 284
HIS A 333
HIS A 334
 CU1  A   5 ( 3.2A)
HEA  A   2 ( 3.3A)
CU1  A   5 (-3.1A)
 0.42A 3s39A-3omnA:
36.7		 3s39A-3omnA:
26.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3A_A_CUA803_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3omn CYTOCHROME C
OXIDASE, AA3 TYPE,
SUBUNIT I
(Rhodobacter
sphaeroides) 		3 / 3 HIS A 284
HIS A 333
HIS A 334
 CU1  A   5 ( 3.2A)
HEA  A   2 ( 3.3A)
CU1  A   5 (-3.1A)
 0.46A 3s3aA-3omnA:
36.1		 3s3aA-3omnA:
26.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3B_A_CUA803_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3omn CYTOCHROME C
OXIDASE, AA3 TYPE,
SUBUNIT I
(Rhodobacter
sphaeroides) 		3 / 3 HIS A 284
HIS A 333
HIS A 334
 CU1  A   5 ( 3.2A)
HEA  A   2 ( 3.3A)
CU1  A   5 (-3.1A)
 0.42A 3s3bA-3omnA:
36.6		 3s3bA-3omnA:
26.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3C_A_CUA803_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3omn CYTOCHROME C
OXIDASE, AA3 TYPE,
SUBUNIT I
(Rhodobacter
sphaeroides) 		3 / 3 HIS A 284
HIS A 333
HIS A 334
 CU1  A   5 ( 3.2A)
HEA  A   2 ( 3.3A)
CU1  A   5 (-3.1A)
 0.50A 3s3cA-3omnA:
36.7		 3s3cA-3omnA:
26.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3D_A_CUA803_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3omn CYTOCHROME C
OXIDASE, AA3 TYPE,
SUBUNIT I
(Rhodobacter
sphaeroides) 		3 / 3 HIS A 284
HIS A 333
HIS A 334
 CU1  A   5 ( 3.2A)
HEA  A   2 ( 3.3A)
CU1  A   5 (-3.1A)
 0.42A 3s3dA-3omnA:
36.6		 3s3dA-3omnA:
26.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V7P_A_BEZA430_0
(AMIDOHYDROLASE
FAMILY PROTEIN)		 1qle CYTOCHROME C OXIDASE
POLYPEPTIDE I-BETA
(Paracoccus
denitrificans) 		5 / 7 ILE A 454
GLY A 455
SER A 456
PHE A 422
LEU A 418
 None
None
HEA  A 601 ( 4.3A)
None
None
 1.23A 3v7pA-1qleA:
undetectable		 3v7pA-1qleA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_A_CHDA1503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1qle CYTOCHROME C OXIDASE
POLYPEPTIDE I-BETA
(Paracoccus
denitrificans) 		4 / 8 ILE A 242
LEU A 245
VAL A 162
GLY A 163
 None
None
None
HEA  A 601 (-3.6A)
 0.73A 3w1wA-1qleA:
undetectable		 3w1wA-1qleA:
20.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3WG7_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3omn CYTOCHROME C
OXIDASE, AA3 TYPE,
SUBUNIT I
(Rhodobacter
sphaeroides) 		3 / 3 HIS A 284
HIS A 333
HIS A 334
 CU1  A   5 ( 3.2A)
HEA  A   2 ( 3.3A)
CU1  A   5 (-3.1A)
 0.15A 3wg7A-3omnA:
57.6		 3wg7A-3omnA:
51.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3WG7_N_CUN603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3omn CYTOCHROME C
OXIDASE, AA3 TYPE,
SUBUNIT I
(Rhodobacter
sphaeroides) 		3 / 3 HIS A 284
HIS A 333
HIS A 334
 CU1  A   5 ( 3.2A)
HEA  A   2 ( 3.3A)
CU1  A   5 (-3.1A)
 0.21A 3wg7N-3omnA:
57.6		 3wg7N-3omnA:
51.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3X2Q_A_CUA604_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3omn CYTOCHROME C
OXIDASE, AA3 TYPE,
SUBUNIT I
(Rhodobacter
sphaeroides) 		3 / 3 HIS A 284
HIS A 333
HIS A 334
 CU1  A   5 ( 3.2A)
HEA  A   2 ( 3.3A)
CU1  A   5 (-3.1A)
 0.20A 3x2qA-3omnA:
57.8		 3x2qA-3omnA:
51.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3X2Q_N_CUN604_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3omn CYTOCHROME C
OXIDASE, AA3 TYPE,
SUBUNIT I
(Rhodobacter
sphaeroides) 		3 / 3 HIS A 284
HIS A 333
HIS A 334
 CU1  A   5 ( 3.2A)
HEA  A   2 ( 3.3A)
CU1  A   5 (-3.1A)
 0.03A 3x2qN-3omnA:
57.9		 3x2qN-3omnA:
51.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BVA_A_T3A1314_1
(THIOMORPHOLINE-CARBO
XYLATE DEHYDROGENASE)		 1qle CYTOCHROME C OXIDASE
POLYPEPTIDE I-BETA
(Paracoccus
denitrificans) 		5 / 12 VAL A 385
GLY A 386
VAL A 415
PHE A 460
HIS A 413
 None
None
HEA  A 602 (-4.2A)
None
HEA  A 601 (-3.4A)
 1.45A 4bvaA-1qleA:
undetectable		 4bvaA-1qleA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BVA_B_T3B1314_1
(THIOMORPHOLINE-CARBO
XYLATE DEHYDROGENASE)		 1qle CYTOCHROME C OXIDASE
POLYPEPTIDE I-BETA
(Paracoccus
denitrificans) 		5 / 12 VAL A 385
GLY A 386
VAL A 415
PHE A 460
HIS A 413
 None
None
HEA  A 602 (-4.2A)
None
HEA  A 601 (-3.4A)
 1.49A 4bvaB-1qleA:
undetectable		 4bvaB-1qleA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FAK_A_SAMA201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)		 1qle CYTOCHROME C OXIDASE
POLYPEPTIDE I-BETA
(Paracoccus
denitrificans) 		5 / 10 LEU A 501
ILE A 504
GLY A 505
PHE A 497
SER A 496
 None
None
None
None
HEA  A 601 ( 4.2A)
 0.85A 4fakA-1qleA:
undetectable		 4fakA-1qleA:
14.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HFP_D_15UD402_1
(PROTHROMBIN)		 3omn CYTOCHROME C
OXIDASE, AA3 TYPE,
SUBUNIT I
(Rhodobacter
sphaeroides) 		5 / 12 TRP A 439
LEU A  34
ILE A 515
ALA A 428
VAL A 111
 None
DMU  A   7 (-4.3A)
DMU  A   7 ( 4.4A)
None
HEA  A   1 (-4.5A)
 1.05A 4hfpD-3omnA:
undetectable		 4hfpD-3omnA:
17.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKJ_B_SUZB201_1
(TRANSTHYRETIN)		 2eij CYTOCHROME C OXIDASE
SUBUNIT 1
(Bos
taurus) 		5 / 8 SER A 458
SER A 454
ALA A  39
LEU A  41
SER A 455
 None
HEA  A 515 ( 4.9A)
None
None
None
 1.33A 4ikjA-2eijA:
undetectable
4ikjB-2eijA:
undetectable		 4ikjA-2eijA:
13.11
4ikjB-2eijA:
13.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKK_A_SUZA201_1
(TRANSTHYRETIN)		 2eij CYTOCHROME C OXIDASE
SUBUNIT 1
(Bos
taurus) 		5 / 8 ALA A  39
LEU A  41
SER A 455
SER A 458
SER A 454
 None
None
None
None
HEA  A 515 ( 4.9A)
 1.30A 4ikkA-2eijA:
undetectable
4ikkB-2eijA:
undetectable		 4ikkA-2eijA:
13.11
4ikkB-2eijA:
13.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JTR_B_IZPB401_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 3omn CYTOCHROME C
OXIDASE, AA3 TYPE,
SUBUNIT I
(Rhodobacter
sphaeroides) 		4 / 6 TYR A 275
VAL A 173
TYR A 175
TRP A 172
 None
None
None
HEA  A   1 ( 4.0A)
 1.44A 4jtrB-3omnA:
undetectable		 4jtrB-3omnA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JX1_B_CAMB502_0
(CAMPHOR
5-MONOOXYGENASE)		 2eij CYTOCHROME C OXIDASE
SUBUNIT 1
(Bos
taurus) 		5 / 10 PHE A 251
THR A 316
GLY A 352
VAL A 243
ILE A 247
 None
HEA  A 516 (-3.8A)
HEA  A 516 (-3.5A)
HEA  A 516 (-4.1A)
HEA  A 516 (-3.6A)
 1.18A 4jx1B-2eijA:
undetectable		 4jx1B-2eijA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NPT_A_017A401_1
(PROTEASE)		 3omn CYTOCHROME C
OXIDASE, AA3 TYPE,
SUBUNIT I
(Rhodobacter
sphaeroides) 		5 / 9 ALA A 428
ILE A 297
GLY A 296
ILE A 112
VAL A 111
 None
None
None
None
HEA  A   1 (-4.5A)
 1.09A 4nptA-3omnA:
undetectable		 4nptA-3omnA:
11.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_D_SAMD601_0
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 1qle CYTOCHROME C OXIDASE
POLYPEPTIDE I-BETA
CYTOCHROME C OXIDASE
POLYPEPTIDE II
(Paracoccus
denitrificans;
Paracoccus
denitrificans) 		5 / 12 GLY A 467
ASN B  15
GLY B  16
ARG A  54
ASN A 486
 None
None
None
HEA  A 601 (-3.1A)
None
 1.14A 4obwD-1qleA:
undetectable		 4obwD-1qleA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKT_A_198A1001_1
(ANDROGEN RECEPTOR)		 3omn CYTOCHROME C
OXIDASE, AA3 TYPE,
SUBUNIT I
(Rhodobacter
sphaeroides) 		5 / 12 LEU A  39
LEU A  42
GLY A  41
THR A 150
MET A 106
 None
None
HEA  A   1 ( 4.1A)
None
HEA  A   1 (-3.8A)
 1.32A 4oktA-3omnA:
undetectable		 4oktA-3omnA:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLM_A_198A1001_1
(ANDROGEN RECEPTOR)		 3omn CYTOCHROME C
OXIDASE, AA3 TYPE,
SUBUNIT I
(Rhodobacter
sphaeroides) 		5 / 12 LEU A  39
LEU A  42
GLY A  41
THR A 150
MET A 106
 None
None
HEA  A   1 ( 4.1A)
None
HEA  A   1 (-3.8A)
 1.38A 4olmA-3omnA:
2.3		 4olmA-3omnA:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_A_29SA601_1
(ESTROGEN RECEPTOR)		 1qle CYTOCHROME C OXIDASE
POLYPEPTIDE I-BETA
CYTOCHROME C OXIDASE
POLYPEPTIDE II
(Paracoccus
denitrificans) 		5 / 12 THR A 405
LEU A  57
ARG A  54
HIS B 224
PRO B  13
 None
None
HEA  A 601 (-3.1A)
CUA  B 301 (-3.1A)
None
 1.31A 4xi3A-1qleA:
2.1		 4xi3A-1qleA:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YO9_A_ACTA403_0
(3C-LIKE PROTEINASE)		 2eij CYTOCHROME C OXIDASE
SUBUNIT 1
(Bos
taurus) 		4 / 5 TYR A 443
SER A 454
LEU A  41
GLN A 428
 None
HEA  A 515 ( 4.9A)
None
HEA  A 515 (-3.8A)
 1.31A 4yo9A-2eijA:
undetectable
4yo9B-2eijA:
undetectable		 4yo9A-2eijA:
20.42
4yo9B-2eijA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YO9_A_ACTA403_0
(3C-LIKE PROTEINASE)		 3omn CYTOCHROME C
OXIDASE, AA3 TYPE,
SUBUNIT I
(Rhodobacter
sphaeroides) 		4 / 5 TYR A 486
SER A 497
LEU A  55
GLN A 471
 None
None
None
HEA  A   1 (-4.0A)
 1.32A 4yo9A-3omnA:
0.0
4yo9B-3omnA:
undetectable		 4yo9A-3omnA:
21.84
4yo9B-3omnA:
21.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5B1A_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3omn CYTOCHROME C
OXIDASE, AA3 TYPE,
SUBUNIT I
(Rhodobacter
sphaeroides) 		3 / 3 HIS A 284
HIS A 333
HIS A 334
 CU1  A   5 ( 3.2A)
HEA  A   2 ( 3.3A)
CU1  A   5 (-3.1A)
 0.13A 5b1aA-3omnA:
57.9		 5b1aA-3omnA:
51.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5B1A_N_CUN603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3omn CYTOCHROME C
OXIDASE, AA3 TYPE,
SUBUNIT I
(Rhodobacter
sphaeroides) 		3 / 3 HIS A 284
HIS A 333
HIS A 334
 CU1  A   5 ( 3.2A)
HEA  A   2 ( 3.3A)
CU1  A   5 (-3.1A)
 0.24A 5b1aN-3omnA:
57.9		 5b1aN-3omnA:
51.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5B1B_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3omn CYTOCHROME C
OXIDASE, AA3 TYPE,
SUBUNIT I
(Rhodobacter
sphaeroides) 		3 / 3 HIS A 284
HIS A 333
HIS A 334
 CU1  A   5 ( 3.2A)
HEA  A   2 ( 3.3A)
CU1  A   5 (-3.1A)
 0.08A 5b1bA-3omnA:
57.6		 5b1bA-3omnA:
51.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5B1B_N_CUN603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3omn CYTOCHROME C
OXIDASE, AA3 TYPE,
SUBUNIT I
(Rhodobacter
sphaeroides) 		3 / 3 HIS A 284
HIS A 333
HIS A 334
 CU1  A   5 ( 3.2A)
HEA  A   2 ( 3.3A)
CU1  A   5 (-3.1A)
 0.18A 5b1bN-3omnA:
57.5		 5b1bN-3omnA:
51.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5B3S_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3omn CYTOCHROME C
OXIDASE, AA3 TYPE,
SUBUNIT I
(Rhodobacter
sphaeroides) 		3 / 3 HIS A 284
HIS A 333
HIS A 334
 CU1  A   5 ( 3.2A)
HEA  A   2 ( 3.3A)
CU1  A   5 (-3.1A)
 0.11A 5b3sA-3omnA:
57.9		 5b3sA-3omnA:
51.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5B3S_N_CUN603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3omn CYTOCHROME C
OXIDASE, AA3 TYPE,
SUBUNIT I
(Rhodobacter
sphaeroides) 		3 / 3 HIS A 284
HIS A 333
HIS A 334
 CU1  A   5 ( 3.2A)
HEA  A   2 ( 3.3A)
CU1  A   5 (-3.1A)
 0.20A 5b3sN-3omnA:
57.9		 5b3sN-3omnA:
51.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESG_A_1YNA701_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3omn CYTOCHROME C
OXIDASE, AA3 TYPE,
SUBUNIT I
(Rhodobacter
sphaeroides) 		5 / 12 PHE A 108
ILE A 104
PHE A 282
VAL A 291
HIS A 333
 None
None
None
HEA  A   2 (-4.2A)
HEA  A   2 ( 3.3A)
 1.20A 5esgA-3omnA:
1.3		 5esgA-3omnA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EWU_B_BEZB1401_0
(MAGNESIUM-CHELATASE
SUBUNIT CHLH,
CHLOROPLASTIC)		 2eij CYTOCHROME C OXIDASE
SUBUNIT 1
(Bos
taurus) 		4 / 6 GLY A 125
THR A  59
VAL A 128
HIS A 138
 HEA  A 515 (-3.2A)
None
None
None
 1.08A 5ewuB-2eijA:
undetectable		 5ewuB-2eijA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW8_C_FK5C201_1
(FK506-BINDING
PROTEIN 1)		 1qle CYTOCHROME C OXIDASE
POLYPEPTIDE I-BETA
CYTOCHROME C OXIDASE
POLYPEPTIDE II
(Paracoccus
denitrificans) 		5 / 10 ILE A 315
TYR A 280
LEU A 284
PHE A 287
ILE B  42
 None
HEA  A 602 (-4.7A)
None
None
None
 1.29A 5hw8C-1qleA:
undetectable
5hw8H-1qleA:
undetectable		 5hw8C-1qleA:
14.15
5hw8H-1qleA:
14.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5IY5_A_CUA601_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3omn CYTOCHROME C
OXIDASE, AA3 TYPE,
SUBUNIT I
(Rhodobacter
sphaeroides) 		3 / 3 HIS A 284
HIS A 333
HIS A 334
 CU1  A   5 ( 3.2A)
HEA  A   2 ( 3.3A)
CU1  A   5 (-3.1A)
 0.15A 5iy5A-3omnA:
57.7		 5iy5A-3omnA:
51.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5IY5_N_CUN602_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3omn CYTOCHROME C
OXIDASE, AA3 TYPE,
SUBUNIT I
(Rhodobacter
sphaeroides) 		3 / 3 HIS A 284
HIS A 333
HIS A 334
 CU1  A   5 ( 3.2A)
HEA  A   2 ( 3.3A)
CU1  A   5 (-3.1A)
 0.13A 5iy5N-3omnA:
57.7		 5iy5N-3omnA:
51.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KOX_A_RFPA502_1
(PENTACHLOROPHENOL
4-MONOOXYGENASE)		 3omn CYTOCHROME C
OXIDASE, AA3 TYPE,
SUBUNIT I
(Rhodobacter
sphaeroides) 		5 / 12 GLY A 360
GLY A 431
VAL A 298
GLY A 394
GLY A 395
 HEA  A   2 (-1.8A)
None
None
None
HEA  A   2 (-3.4A)
 0.81A 5koxA-3omnA:
undetectable		 5koxA-3omnA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L6E_A_SAMA601_0
(N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT)		 1qle CYTOCHROME C OXIDASE
POLYPEPTIDE I-BETA
(Paracoccus
denitrificans) 		5 / 12 ILE A 283
PHE A 287
GLY A 288
HIS A 292
GLY A 286
 HEA  A 602 ( 4.3A)
None
None
None
None
 1.18A 5l6eA-1qleA:
undetectable		 5l6eA-1qleA:
15.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LBT_A_6T0A303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 3omn CYTOCHROME C
OXIDASE, AA3 TYPE,
SUBUNIT I
(Rhodobacter
sphaeroides) 		5 / 10 PHE A 295
ILE A 363
PHE A 387
GLY A 395
GLY A 394
 None
HEA  A   2 ( 4.4A)
None
HEA  A   2 (-3.4A)
None
 1.46A 5lbtA-3omnA:
undetectable
5lbtB-3omnA:
undetectable		 5lbtA-3omnA:
18.84
5lbtB-3omnA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0X_B_SAMB501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 1qle CYTOCHROME C OXIDASE
POLYPEPTIDE I-BETA
(Paracoccus
denitrificans) 		5 / 12 ILE A 424
GLY A 423
VAL A 293
PHE A 220
ALA A 106
 None
None
None
None
HEA  A 601 (-3.3A)
 1.24A 5n0xB-1qleA:
undetectable		 5n0xB-1qleA:
21.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5W97_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3omn CYTOCHROME C
OXIDASE, AA3 TYPE,
SUBUNIT I
(Rhodobacter
sphaeroides) 		3 / 3 HIS A 284
HIS A 333
HIS A 334
 CU1  A   5 ( 3.2A)
HEA  A   2 ( 3.3A)
CU1  A   5 (-3.1A)
 0.14A 5w97a-3omnA:
57.4		 5w97a-3omnA:
51.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5WAU_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3omn CYTOCHROME C
OXIDASE, AA3 TYPE,
SUBUNIT I
(Rhodobacter
sphaeroides) 		3 / 3 HIS A 284
HIS A 333
HIS A 334
 CU1  A   5 ( 3.2A)
HEA  A   2 ( 3.3A)
CU1  A   5 (-3.1A)
 0.15A 5waua-3omnA:
57.7		 5waua-3omnA:
51.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5X19_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3omn CYTOCHROME C
OXIDASE, AA3 TYPE,
SUBUNIT I
(Rhodobacter
sphaeroides) 		3 / 3 HIS A 284
HIS A 333
HIS A 334
 CU1  A   5 ( 3.2A)
HEA  A   2 ( 3.3A)
CU1  A   5 (-3.1A)
 0.13A 5x19A-3omnA:
57.3		 5x19A-3omnA:
51.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5X19_N_CUN603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3omn CYTOCHROME C
OXIDASE, AA3 TYPE,
SUBUNIT I
(Rhodobacter
sphaeroides) 		3 / 3 HIS A 284
HIS A 333
HIS A 334
 CU1  A   5 ( 3.2A)
HEA  A   2 ( 3.3A)
CU1  A   5 (-3.1A)
 0.20A 5x19N-3omnA:
57.2		 5x19N-3omnA:
51.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5X1B_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3omn CYTOCHROME C
OXIDASE, AA3 TYPE,
SUBUNIT I
(Rhodobacter
sphaeroides) 		3 / 3 HIS A 284
HIS A 333
HIS A 334
 CU1  A   5 ( 3.2A)
HEA  A   2 ( 3.3A)
CU1  A   5 (-3.1A)
 0.21A 5x1bA-3omnA:
56.6		 5x1bA-3omnA:
51.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5X1B_N_CUN603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3omn CYTOCHROME C
OXIDASE, AA3 TYPE,
SUBUNIT I
(Rhodobacter
sphaeroides) 		3 / 3 HIS A 284
HIS A 333
HIS A 334
 CU1  A   5 ( 3.2A)
HEA  A   2 ( 3.3A)
CU1  A   5 (-3.1A)
 0.13A 5x1bN-3omnA:
56.4		 5x1bN-3omnA:
51.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5X1F_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3omn CYTOCHROME C
OXIDASE, AA3 TYPE,
SUBUNIT I
(Rhodobacter
sphaeroides) 		3 / 3 HIS A 284
HIS A 333
HIS A 334
 CU1  A   5 ( 3.2A)
HEA  A   2 ( 3.3A)
CU1  A   5 (-3.1A)
 0.16A 5x1fA-3omnA:
57.3		 5x1fA-3omnA:
51.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5X1F_N_CUN603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3omn CYTOCHROME C
OXIDASE, AA3 TYPE,
SUBUNIT I
(Rhodobacter
sphaeroides) 		3 / 3 HIS A 284
HIS A 333
HIS A 334
 CU1  A   5 ( 3.2A)
HEA  A   2 ( 3.3A)
CU1  A   5 (-3.1A)
 0.08A 5x1fN-3omnA:
57.3		 5x1fN-3omnA:
51.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5XDQ_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3omn CYTOCHROME C
OXIDASE, AA3 TYPE,
SUBUNIT I
(Rhodobacter
sphaeroides) 		3 / 3 HIS A 284
HIS A 333
HIS A 334
 CU1  A   5 ( 3.2A)
HEA  A   2 ( 3.3A)
CU1  A   5 (-3.1A)
 0.17A 5xdqA-3omnA:
57.9		 5xdqA-3omnA:
51.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5XDQ_N_CUN603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3omn CYTOCHROME C
OXIDASE, AA3 TYPE,
SUBUNIT I
(Rhodobacter
sphaeroides) 		3 / 3 HIS A 284
HIS A 333
HIS A 334
 CU1  A   5 ( 3.2A)
HEA  A   2 ( 3.3A)
CU1  A   5 (-3.1A)
 0.20A 5xdqN-3omnA:
57.9		 5xdqN-3omnA:
51.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5XDX_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3omn CYTOCHROME C
OXIDASE, AA3 TYPE,
SUBUNIT I
(Rhodobacter
sphaeroides) 		3 / 3 HIS A 284
HIS A 333
HIS A 334
 CU1  A   5 ( 3.2A)
HEA  A   2 ( 3.3A)
CU1  A   5 (-3.1A)
 0.08A 5xdxA-3omnA:
57.5		 5xdxA-3omnA:
51.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5XDX_N_CUN603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3omn CYTOCHROME C
OXIDASE, AA3 TYPE,
SUBUNIT I
(Rhodobacter
sphaeroides) 		3 / 3 HIS A 284
HIS A 333
HIS A 334
 CU1  A   5 ( 3.2A)
HEA  A   2 ( 3.3A)
CU1  A   5 (-3.1A)
 0.07A 5xdxN-3omnA:
57.5		 5xdxN-3omnA:
51.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5Z84_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3omn CYTOCHROME C
OXIDASE, AA3 TYPE,
SUBUNIT I
(Rhodobacter
sphaeroides) 		3 / 3 HIS A 284
HIS A 333
HIS A 334
 CU1  A   5 ( 3.2A)
HEA  A   2 ( 3.3A)
CU1  A   5 (-3.1A)
 0.23A 5z84A-3omnA:
58.0		 5z84A-3omnA:
51.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5Z84_N_CUN604_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3omn CYTOCHROME C
OXIDASE, AA3 TYPE,
SUBUNIT I
(Rhodobacter
sphaeroides) 		3 / 3 HIS A 284
HIS A 333
HIS A 334
 CU1  A   5 ( 3.2A)
HEA  A   2 ( 3.3A)
CU1  A   5 (-3.1A)
 0.26A 5z84N-3omnA:
58.0		 5z84N-3omnA:
51.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5Z85_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3omn CYTOCHROME C
OXIDASE, AA3 TYPE,
SUBUNIT I
(Rhodobacter
sphaeroides) 		3 / 3 HIS A 284
HIS A 333
HIS A 334
 CU1  A   5 ( 3.2A)
HEA  A   2 ( 3.3A)
CU1  A   5 (-3.1A)
 0.26A 5z85A-3omnA:
58.0		 5z85A-3omnA:
51.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5Z85_N_CUN603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3omn CYTOCHROME C
OXIDASE, AA3 TYPE,
SUBUNIT I
(Rhodobacter
sphaeroides) 		3 / 3 HIS A 284
HIS A 333
HIS A 334
 CU1  A   5 ( 3.2A)
HEA  A   2 ( 3.3A)
CU1  A   5 (-3.1A)
 0.26A 5z85N-3omnA:
58.0		 5z85N-3omnA:
51.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5Z86_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3omn CYTOCHROME C
OXIDASE, AA3 TYPE,
SUBUNIT I
(Rhodobacter
sphaeroides) 		3 / 3 HIS A 284
HIS A 333
HIS A 334
 CU1  A   5 ( 3.2A)
HEA  A   2 ( 3.3A)
CU1  A   5 (-3.1A)
 0.11A 5z86A-3omnA:
58.0		 5z86A-3omnA:
51.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5Z86_N_CUN603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3omn CYTOCHROME C
OXIDASE, AA3 TYPE,
SUBUNIT I
(Rhodobacter
sphaeroides) 		3 / 3 HIS A 284
HIS A 333
HIS A 334
 CU1  A   5 ( 3.2A)
HEA  A   2 ( 3.3A)
CU1  A   5 (-3.1A)
 0.25A 5z86N-3omnA:
58.0		 5z86N-3omnA:
51.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ZCO_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3omn CYTOCHROME C
OXIDASE, AA3 TYPE,
SUBUNIT I
(Rhodobacter
sphaeroides) 		3 / 3 HIS A 284
HIS A 333
HIS A 334
 CU1  A   5 ( 3.2A)
HEA  A   2 ( 3.3A)
CU1  A   5 (-3.1A)
 0.19A 5zcoA-3omnA:
57.9		 5zcoA-3omnA:
51.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ZCO_N_CUN604_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3omn CYTOCHROME C
OXIDASE, AA3 TYPE,
SUBUNIT I
(Rhodobacter
sphaeroides) 		3 / 3 HIS A 284
HIS A 333
HIS A 334
 CU1  A   5 ( 3.2A)
HEA  A   2 ( 3.3A)
CU1  A   5 (-3.1A)
 0.17A 5zcoN-3omnA:
58.0		 5zcoN-3omnA:
51.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ZCP_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3omn CYTOCHROME C
OXIDASE, AA3 TYPE,
SUBUNIT I
(Rhodobacter
sphaeroides) 		3 / 3 HIS A 284
HIS A 333
HIS A 334
 CU1  A   5 ( 3.2A)
HEA  A   2 ( 3.3A)
CU1  A   5 (-3.1A)
 0.17A 5zcpA-3omnA:
58.0		 5zcpA-3omnA:
51.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ZCP_N_CUN604_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3omn CYTOCHROME C
OXIDASE, AA3 TYPE,
SUBUNIT I
(Rhodobacter
sphaeroides) 		3 / 3 HIS A 284
HIS A 333
HIS A 334
 CU1  A   5 ( 3.2A)
HEA  A   2 ( 3.3A)
CU1  A   5 (-3.1A)
 0.27A 5zcpN-3omnA:
58.0		 5zcpN-3omnA:
51.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ZCQ_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3omn CYTOCHROME C
OXIDASE, AA3 TYPE,
SUBUNIT I
(Rhodobacter
sphaeroides) 		3 / 3 HIS A 284
HIS A 333
HIS A 334
 CU1  A   5 ( 3.2A)
HEA  A   2 ( 3.3A)
CU1  A   5 (-3.1A)
 0.19A 5zcqA-3omnA:
58.0		 5zcqA-3omnA:
51.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ZCQ_N_CUN603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3omn CYTOCHROME C
OXIDASE, AA3 TYPE,
SUBUNIT I
(Rhodobacter
sphaeroides) 		3 / 3 HIS A 284
HIS A 333
HIS A 334
 CU1  A   5 ( 3.2A)
HEA  A   2 ( 3.3A)
CU1  A   5 (-3.1A)
 0.20A 5zcqN-3omnA:
58.0		 5zcqN-3omnA:
51.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_A_ACRA606_0
(ALPHA-AMYLASE)		 3omn CYTOCHROME C
OXIDASE, AA3 TYPE,
SUBUNIT I
(Rhodobacter
sphaeroides) 		5 / 7 GLY A  38
GLY A  37
PRO A 113
GLY A 117
GLY A 118
 HEA  A   1 (-3.6A)
None
None
None
None
 0.99A 6ag0A-3omnA:
undetectable		 6ag0A-3omnA:
10.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BRD_B_RFPB502_1
(RIFAMPIN
MONOOXYGENASE)		 1qle CYTOCHROME C OXIDASE
POLYPEPTIDE I-BETA
(Paracoccus
denitrificans) 		5 / 12 HIS A 411
GLY A 286
THR A 384
GLY A 387
GLY A 386
 HEA  A 602 (-3.4A)
None
HEA  A 602 ( 4.7A)
HEA  A 602 (-3.3A)
None
 1.22A 6brdB-1qleA:
0.0		 6brdB-1qleA:
9.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BRD_B_RFPB502_1
(RIFAMPIN
MONOOXYGENASE)		 1qle CYTOCHROME C OXIDASE
POLYPEPTIDE I-BETA
(Paracoccus
denitrificans) 		5 / 12 HIS A 411
GLY A 423
THR A 384
GLY A 387
GLY A 386
 HEA  A 602 (-3.4A)
None
HEA  A 602 ( 4.7A)
HEA  A 602 (-3.3A)
None
 1.16A 6brdB-1qleA:
0.0		 6brdB-1qleA:
9.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BRD_B_RFPB502_1
(RIFAMPIN
MONOOXYGENASE)		 2eij CYTOCHROME C OXIDASE
SUBUNIT 1
(Bos
taurus) 		5 / 12 HIS A 376
GLY A 250
THR A 349
GLY A 352
GLY A 351
 HEA  A 516 (-3.3A)
None
HEA  A 516 ( 4.2A)
HEA  A 516 (-3.5A)
None
 1.10A 6brdB-2eijA:
undetectable		 6brdB-2eijA:
11.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BRD_B_RFPB502_1
(RIFAMPIN
MONOOXYGENASE)		 3omn CYTOCHROME C
OXIDASE, AA3 TYPE,
SUBUNIT I
(Rhodobacter
sphaeroides) 		5 / 12 HIS A 419
GLY A 431
THR A 392
GLY A 395
GLY A 394
 HEA  A   2 (-3.2A)
None
HEA  A   2 ( 3.9A)
HEA  A   2 (-3.4A)
None
 1.08A 6brdB-3omnA:
undetectable		 6brdB-3omnA:
9.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E8Q_A_X2NA602_0
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2eij CYTOCHROME C OXIDASE
SUBUNIT 1
(Bos
taurus) 		5 / 12 ILE A 389
GLY A  27
THR A  31
PHE A 377
THR A  59
 None
HEA  A 515 ( 3.8A)
HEA  A 515 (-3.3A)
HEA  A 516 ( 4.1A)
None
 1.18A 6e8qA-2eijA:
undetectable		 6e8qA-2eijA:
10.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6GIQ_A_CUA601_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3omn CYTOCHROME C
OXIDASE, AA3 TYPE,
SUBUNIT I
(Rhodobacter
sphaeroides) 		3 / 3 HIS A 284
HIS A 333
HIS A 334
 CU1  A   5 ( 3.2A)
HEA  A   2 ( 3.3A)
CU1  A   5 (-3.1A)
 0.62A 6giqa-3omnA:
48.7		 6giqa-3omnA:
52.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6HU9_A_CUA601_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3omn CYTOCHROME C
OXIDASE, AA3 TYPE,
SUBUNIT I
(Rhodobacter
sphaeroides) 		3 / 3 HIS A 284
HIS A 333
HIS A 334
 CU1  A   5 ( 3.2A)
HEA  A   2 ( 3.3A)
CU1  A   5 (-3.1A)
 0.21A 6hu9a-3omnA:
55.7		 6hu9a-3omnA:
52.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6HU9_M_CUM601_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3omn CYTOCHROME C
OXIDASE, AA3 TYPE,
SUBUNIT I
(Rhodobacter
sphaeroides) 		3 / 3 HIS A 284
HIS A 333
HIS A 334
 CU1  A   5 ( 3.2A)
HEA  A   2 ( 3.3A)
CU1  A   5 (-3.1A)
 0.32A 6hu9m-3omnA:
55.6		 6hu9m-3omnA:
52.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_N_PCFN606_0
(CYTOCHROME B)		 3omn CYTOCHROME C
OXIDASE, AA3 TYPE,
SUBUNIT I
(Rhodobacter
sphaeroides) 		5 / 12 ALA A 351
THR A 343
VAL A 329
VAL A 325
TYR A 288
 None
None
None
None
HEA  A   2 (-4.6A)
 1.42A 6hu9N-3omnA:
undetectable		 6hu9N-3omnA:
22.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6NKN_A_CUA601_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3omn CYTOCHROME C
OXIDASE, AA3 TYPE,
SUBUNIT I
(Rhodobacter
sphaeroides) 		3 / 3 HIS A 284
HIS A 333
HIS A 334
 CU1  A   5 ( 3.2A)
HEA  A   2 ( 3.3A)
CU1  A   5 (-3.1A)
 0.21A 6nknA-3omnA:
57.0		 6nknA-3omnA:
51.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6NKN_N_CUN602_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3omn CYTOCHROME C
OXIDASE, AA3 TYPE,
SUBUNIT I
(Rhodobacter
sphaeroides) 		3 / 3 HIS A 284
HIS A 333
HIS A 334
 CU1  A   5 ( 3.2A)
HEA  A   2 ( 3.3A)
CU1  A   5 (-3.1A)
 0.23A 6nknN-3omnA:
57.0		 6nknN-3omnA:
51.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6NMF_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3omn CYTOCHROME C
OXIDASE, AA3 TYPE,
SUBUNIT I
(Rhodobacter
sphaeroides) 		3 / 3 HIS A 284
HIS A 333
HIS A 334
 CU1  A   5 ( 3.2A)
HEA  A   2 ( 3.3A)
CU1  A   5 (-3.1A)
 0.15A 6nmfA-3omnA:
56.9		 6nmfA-3omnA:
51.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6NMF_N_CUN603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3omn CYTOCHROME C
OXIDASE, AA3 TYPE,
SUBUNIT I
(Rhodobacter
sphaeroides) 		3 / 3 HIS A 284
HIS A 333
HIS A 334
 CU1  A   5 ( 3.2A)
HEA  A   2 ( 3.3A)
CU1  A   5 (-3.1A)
 0.13A 6nmfN-3omnA:
56.6		 6nmfN-3omnA:
51.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6NMP_A_CUA601_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3omn CYTOCHROME C
OXIDASE, AA3 TYPE,
SUBUNIT I
(Rhodobacter
sphaeroides) 		3 / 3 HIS A 284
HIS A 333
HIS A 334
 CU1  A   5 ( 3.2A)
HEA  A   2 ( 3.3A)
CU1  A   5 (-3.1A)
 0.19A 6nmpA-3omnA:
57.1		 6nmpA-3omnA:
51.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6NMP_N_CUN601_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3omn CYTOCHROME C
OXIDASE, AA3 TYPE,
SUBUNIT I
(Rhodobacter
sphaeroides) 		3 / 3 HIS A 284
HIS A 333
HIS A 334
 CU1  A   5 ( 3.2A)
HEA  A   2 ( 3.3A)
CU1  A   5 (-3.1A)
 0.21A 6nmpN-3omnA:
56.8		 6nmpN-3omnA:
51.18