SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'HE3'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CCF_A_BEZA261_0
(CYCLOPROPANE-FATTY-A
CYL-PHOSPHOLIPID
SYNTHASE)		 1ozh ACETOLACTATE
SYNTHASE, CATABOLIC
(Klebsiella
pneumoniae) 		4 / 8 ASN A 546
TRP A 472
PHE A 397
TYR A 543
 None
None
HE3  A1406 (-4.7A)
HE3  A1406 (-4.4A)
 1.28A 3ccfA-1ozhA:
3.2		 3ccfA-1ozhA:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CCF_B_BEZB261_0
(CYCLOPROPANE-FATTY-A
CYL-PHOSPHOLIPID
SYNTHASE)		 1ozh ACETOLACTATE
SYNTHASE, CATABOLIC
(Klebsiella
pneumoniae) 		4 / 8 ASN A 546
TRP A 472
PHE A 397
TYR A 543
 None
None
HE3  A1406 (-4.7A)
HE3  A1406 (-4.4A)
 1.25A 3ccfB-1ozhA:
3.5		 3ccfB-1ozhA:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DJF_B_C2FB300_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 1ozh ACETOLACTATE
SYNTHASE, CATABOLIC
(Klebsiella
pneumoniae) 		5 / 12 PHE A 501
ASP A 474
ILE A 482
GLY A 395
SER A 445
 None
MG  A1405 ( 2.3A)
None
HE3  A1406 (-3.4A)
None
 1.33A 4djfB-1ozhA:
undetectable		 4djfB-1ozhA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L8F_D_MTXD301_1
(GAMMA-GLUTAMYL
HYDROLASE)		 1ozh ACETOLACTATE
SYNTHASE, CATABOLIC
(Klebsiella
pneumoniae) 		5 / 11 PHE A 496
GLY A 423
GLY A 449
GLY A 448
HIS A 398
 None
None
HE3  A1406 (-3.7A)
HE3  A1406 (-3.4A)
None
 1.12A 4l8fD-1ozhA:
2.4		 4l8fD-1ozhA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJO_D_ERYD1101_0
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 1ozh ACETOLACTATE
SYNTHASE, CATABOLIC
(Klebsiella
pneumoniae) 		5 / 11 THR A  90
ALA A  66
GLU A 456
ASP A 393
GLY A 449
 None
None
None
None
HE3  A1406 (-3.7A)
 1.36A 4zjoD-1ozhA:
undetectable		 4zjoD-1ozhA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NJ9_K_SAMK500_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC)		 1ozh ACETOLACTATE
SYNTHASE, CATABOLIC
(Klebsiella
pneumoniae) 		5 / 12 GLY A 497
GLY A 448
GLY A 476
VAL A 473
PHE A 501
 None
HE3  A1406 (-3.4A)
MG  A1405 ( 4.0A)
None
None
 1.09A 6nj9K-1ozhA:
2.2		 6nj9K-1ozhA:
20.78