SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'HDH'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3DOU_A_SAMA1_0 (RIBOSOMAL RNA LARGE SUBUNIT METHYLTRANSFERASE J)	5h6s	AMIDASE (Microbacterium sp. HM58-2)	6 / 12	ALA A 123 GLY A 174 SER A 155 GLY A 157 GLY A 158 LEU A 176	None None HDH A 600 (-3.3A) None None HDH A 600 (-4.2A)	1.20A	3douA-5h6sA: undetectable	3douA-5h6sA: 15.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3IV6_D_SAMD301_0 (PUTATIVE ZN-DEPENDENT ALCOHOL DEHYDROGENASE)	5h6s	AMIDASE (Microbacterium sp. HM58-2)	5 / 12	GLY A 173 SER A 156 SER A 78 ASP A 175 ARG A 181	None None None HDH A 600 ( 4.9A) None	1.26A	3iv6D-5h6sA: undetectable	3iv6D-5h6sA: 21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4DAN_B_2FAB301_1 (PURINE NUCLEOSIDE PHOSPHORYLASE DEOD-TYPE)	5h6s	AMIDASE (Microbacterium sp. HM58-2)	5 / 12	HIS A 336 SER A 155 GLY A 178 VAL A 182 VAL A 410	None HDH A 600 (-3.3A) HDH A 600 (-4.3A) None None	1.09A	4danA-5h6sA: undetectable 4danB-5h6sA: undetectable	4danA-5h6sA: 22.59 4danB-5h6sA: 22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5YWM_X_NIOX403_0 (CASEIN KINASE II SUBUNIT ALPHA')	5h6s	AMIDASE (Microbacterium sp. HM58-2)	4 / 7	VAL A 325 VAL A 321 ILE A 130 ASP A 127	None None HDH A 600 ( 4.0A) None	0.72A	5ywmX-5h6sA: undetectable	5ywmX-5h6sA: 10.57

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["3DOU_A_SAMA1_0","RIBOSOMAL RNA LARGE SUBUNIT METHYLTRANSFERASE J","5h6s","AMIDASE","Microbacterium sp. HM58-2",6,"ALA A 123;GLY A 174;SER A 155;GLY A 157;GLY A 158;LEU A 176","None;None;HDH A 600 (-3.3A);None;None;HDH A 600 (-4.2A)","1.20A","3douA-5h6sA:undetectable",null],["3IV6_D_SAMD301_0","PUTATIVE ZN-DEPENDENT ALCOHOL DEHYDROGENASE","5h6s","AMIDASE","Microbacterium sp. HM58-2",5,"GLY A 173;SER A 156;SER A  78;ASP A 175;ARG A 181","None;None;None;HDH A 600 ( 4.9A);None","1.26A","3iv6D-5h6sA:undetectable","3douA-5h6sA:15.80"],["4DAN_B_2FAB301_1","PURINE NUCLEOSIDE PHOSPHORYLASE DEOD-TYPE;PURINE NUCLEOSIDE PHOSPHORYLASE DEOD-TYPE","5h6s","AMIDASE","Microbacterium sp. HM58-2",5,"HIS A 336;SER A 155;GLY A 178;VAL A 182;VAL A 410","None;HDH A 600 (-3.3A);HDH A 600 (-4.3A);None;None","1.09A","4danA-5h6sA:undetectable;4danB-5h6sA:undetectable","3iv6D-5h6sA:21.04"],["5YWM_X_NIOX403_0","CASEIN KINASE II SUBUNIT ALPHA'","5h6s","AMIDASE","Microbacterium sp. HM58-2",4,"VAL A 325;VAL A 321;ILE A 130;ASP A 127","None;None;HDH A 600 ( 4.0A);None","0.72A","5ywmX-5h6sA:undetectable","4danA-5h6sA:22.59;4danB-5h6sA:22.59"]]