SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'HDC'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1S9A_A_BEZA306_0 (CHLOROCATECHOL 1,2-DIOXYGENASE)	1pn4	PEROXISOMAL HYDRATASE-DEHYDROGEN ASE-EPIMERASE (Candida tropicalis)	5 / 11	LEU A 211 GLY A 205 TYR A 177 TYR A 17 HIS A 46	None HDC A1277 (-3.4A) None None None	1.44A	1s9aA-1pn4A: undetectable	1s9aA-1pn4A: 22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1XOQ_A_ROFA502_1 (CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4D)	1pn4	PEROXISOMAL HYDRATASE-DEHYDROGEN ASE-EPIMERASE (Candida tropicalis)	3 / 3	ASN A 51 TRP A 7 GLN A 56	None None HDC A1277 ( 4.6A)	0.99A	1xoqA-1pn4A: undetectable	1xoqA-1pn4A: 19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2BTE_A_LEUA1894_0 (AMINOACYL-TRNA SYNTHETASE)	1pn4	PEROXISOMAL HYDRATASE-DEHYDROGEN ASE-EPIMERASE (Candida tropicalis)	4 / 8	MET A 206 ASP A 182 TYR A 177 HIS A 46	None HDC A1277 (-2.8A) None None	1.36A	2bteA-1pn4A: undetectable	2bteA-1pn4A: 15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2BTE_D_LEUD1893_0 (AMINOACYL-TRNA SYNTHETASE)	1pn4	PEROXISOMAL HYDRATASE-DEHYDROGEN ASE-EPIMERASE (Candida tropicalis)	4 / 8	MET A 206 ASP A 182 TYR A 177 HIS A 46	None HDC A1277 (-2.8A) None None	1.34A	2bteD-1pn4A: undetectable	2bteD-1pn4A: 15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2BYT_A_LEUA1301_0 (LEUCYL-TRNA SYNTHETASE)	1pn4	PEROXISOMAL HYDRATASE-DEHYDROGEN ASE-EPIMERASE (Candida tropicalis)	4 / 7	MET A 206 ASP A 182 TYR A 177 HIS A 46	None HDC A1277 (-2.8A) None None	1.36A	2bytA-1pn4A: undetectable	2bytA-1pn4A: 15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2BYT_D_LEUD1601_0 (LEUCYL-TRNA SYNTHETASE)	1pn4	PEROXISOMAL HYDRATASE-DEHYDROGEN ASE-EPIMERASE (Candida tropicalis)	4 / 7	MET A 206 ASP A 182 TYR A 177 HIS A 46	None HDC A1277 (-2.8A) None None	1.36A	2bytD-1pn4A: undetectable	2bytD-1pn4A: 15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5AJQ_B_DB8B800_1 (SERINE/THREONINE-PRO TEIN KINASE 10)	1pn4	PEROXISOMAL HYDRATASE-DEHYDROGEN ASE-EPIMERASE (Candida tropicalis)	5 / 10	ILE A 109 PHE A 132 GLY A 104 ALA A 138 ASP A 139	None HDC A1277 (-3.9A) None None None	1.49A	5ajqB-1pn4A: undetectable	5ajqB-1pn4A: 21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5MM4_B_TA1B501_1 (TUBULIN BETA CHAIN)	1pn4	PEROXISOMAL HYDRATASE-DEHYDROGEN ASE-EPIMERASE (Candida tropicalis)	5 / 10	ALA A 60 PHE A 59 THR A 130 PRO A 68 LEU A 71	None None HDC A1277 ( 4.9A) EDO A 504 (-4.6A) EDO A 504 (-4.1A)	1.45A	5mm4B-1pn4A: undetectable	5mm4B-1pn4A: 14.07

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1S9A_A_BEZA306_0","CHLOROCATECHOL 1,2-DIOXYGENASE","1pn4","PEROXISOMAL HYDRATASE-DEHYDROGENASE-EPIMERASE","Candida tropicalis",5,"LEU A 211;GLY A 205;TYR A 177;TYR A  17;HIS A  46","None;HDC A1277 (-3.4A);None;None;None","1.44A","1s9aA-1pn4A:undetectable",null],["1XOQ_A_ROFA502_1","CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4D","1pn4","PEROXISOMAL HYDRATASE-DEHYDROGENASE-EPIMERASE","Candida tropicalis",3,"ASN A  51;TRP A   7;GLN A  56","None;None;HDC A1277 ( 4.6A)","0.99A","1xoqA-1pn4A:undetectable","1s9aA-1pn4A:22.03"],["2BTE_A_LEUA1894_0","AMINOACYL-TRNA SYNTHETASE","1pn4","PEROXISOMAL HYDRATASE-DEHYDROGENASE-EPIMERASE","Candida tropicalis",4,"MET A 206;ASP A 182;TYR A 177;HIS A  46","None;HDC A1277 (-2.8A);None;None","1.36A","2bteA-1pn4A:undetectable","1xoqA-1pn4A:19.40"],["2BTE_D_LEUD1893_0","AMINOACYL-TRNA SYNTHETASE","1pn4","PEROXISOMAL HYDRATASE-DEHYDROGENASE-EPIMERASE","Candida tropicalis",4,"MET A 206;ASP A 182;TYR A 177;HIS A  46","None;HDC A1277 (-2.8A);None;None","1.34A","2bteD-1pn4A:undetectable","2bteA-1pn4A:15.35"],["2BYT_A_LEUA1301_0","LEUCYL-TRNA SYNTHETASE","1pn4","PEROXISOMAL HYDRATASE-DEHYDROGENASE-EPIMERASE","Candida tropicalis",4,"MET A 206;ASP A 182;TYR A 177;HIS A  46","None;HDC A1277 (-2.8A);None;None","1.36A","2bytA-1pn4A:undetectable","2bteD-1pn4A:15.35"],["2BYT_D_LEUD1601_0","LEUCYL-TRNA SYNTHETASE","1pn4","PEROXISOMAL HYDRATASE-DEHYDROGENASE-EPIMERASE","Candida tropicalis",4,"MET A 206;ASP A 182;TYR A 177;HIS A  46","None;HDC A1277 (-2.8A);None;None","1.36A","2bytD-1pn4A:undetectable","2bytA-1pn4A:15.35"],["5AJQ_B_DB8B800_1","SERINE\/THREONINE-PROTEIN KINASE 10","1pn4","PEROXISOMAL HYDRATASE-DEHYDROGENASE-EPIMERASE","Candida tropicalis",5,"ILE A 109;PHE A 132;GLY A 104;ALA A 138;ASP A 139","None;HDC A1277 (-3.9A);None;None;None","1.49A","5ajqB-1pn4A:undetectable","2bytD-1pn4A:15.35"],["5MM4_B_TA1B501_1","TUBULIN BETA CHAIN","1pn4","PEROXISOMAL HYDRATASE-DEHYDROGENASE-EPIMERASE","Candida tropicalis",5,"ALA A  60;PHE A  59;THR A 130;PRO A  68;LEU A  71","None;None;HDC A1277 ( 4.9A);EDO A 504 (-4.6A);EDO A 504 (-4.1A)","1.45A","5mm4B-1pn4A:undetectable","5ajqB-1pn4A:21.94"]]