SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'HCY'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QE6_B_SAMB400_1
(UNCHARACTERIZED
PROTEIN TFU_2867)		 2v95 CORTICOSTEROID-BINDI
NG GLOBULIN
(Rattus
norvegicus) 		3 / 3 ASN A   7
ARG A  10
ASP A 256
 None
None
HCY  A1375 (-3.6A)
 1.00A 2qe6B-2v95A:
undetectable		 2qe6B-2v95A:
21.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2V95_A_HCYA1375_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 5hgc SERPIN
(Taeniopygia
guttata) 		5 / 12 PRO A  33
THR A 254
PHE A 256
ILE A 277
PHE A 380
 HCY  A 501 (-3.8A)
HCY  A 501 ( 4.1A)
HCY  A 501 (-4.8A)
HCY  A 501 ( 4.2A)
HCY  A 501 (-4.2A)
 0.54A 2v95A-5hgcA:
43.9		 2v95A-5hgcA:
39.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2VDY_A_HCYA1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 2v95 CORTICOSTEROID-BINDI
NG GLOBULIN
(Rattus
norvegicus) 		8 / 12 VAL A  17
GLN A 224
THR A 232
PHE A 234
ARG A 252
ILE A 255
PHE A 357
TRP A 362
 HCY  A1375 ( 4.8A)
HCY  A1375 (-3.5A)
HCY  A1375 ( 4.2A)
HCY  A1375 (-4.8A)
HCY  A1375 (-4.9A)
None
HCY  A1375 ( 4.1A)
HCY  A1375 (-3.8A)
 0.64A 2vdyA-2v95A:
38.4		 2vdyA-2v95A:
60.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2VDY_B_HCYB1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 2v95 CORTICOSTEROID-BINDI
NG GLOBULIN
(Rattus
norvegicus) 		8 / 12 VAL A  17
GLN A 224
THR A 232
PHE A 234
ARG A 252
ILE A 255
PHE A 357
TRP A 362
 HCY  A1375 ( 4.8A)
HCY  A1375 (-3.5A)
HCY  A1375 ( 4.2A)
HCY  A1375 (-4.8A)
HCY  A1375 (-4.9A)
None
HCY  A1375 ( 4.1A)
HCY  A1375 (-3.8A)
 0.61A 2vdyB-2v95A:
38.1		 2vdyB-2v95A:
60.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2VDY_B_HCYB1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 5hgc SERPIN
(Taeniopygia
guttata) 		5 / 12 THR A 254
PHE A 256
ILE A 277
SER A 281
PHE A 380
 HCY  A 501 ( 4.1A)
HCY  A 501 (-4.8A)
HCY  A 501 ( 4.2A)
HCY  A 501 (-3.0A)
HCY  A 501 (-4.2A)
 0.62A 2vdyB-5hgcA:
43.9		 2vdyB-5hgcA:
42.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4BB2_B_STRB1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 2v95 CORTICOSTEROID-BINDI
NG GLOBULIN
(Rattus
norvegicus) 		7 / 11 ALA A  13
GLN A 224
THR A 232
PHE A 234
ARG A 252
ILE A 255
TRP A 362
 HCY  A1375 (-3.6A)
HCY  A1375 (-3.5A)
HCY  A1375 ( 4.2A)
HCY  A1375 (-4.8A)
HCY  A1375 (-4.9A)
None
HCY  A1375 (-3.8A)
 0.59A 4bb2A-2v95A:
30.2
4bb2B-2v95A:
undetectable		 4bb2A-2v95A:
56.80
4bb2B-2v95A:
5.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4BB2_B_STRB1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 2v95 CORTICOSTEROID-BINDI
NG GLOBULIN
(Rattus
norvegicus) 		5 / 11 ALA A  20
GLN A 224
THR A 232
PHE A 234
ILE A 255
 None
HCY  A1375 (-3.5A)
HCY  A1375 ( 4.2A)
HCY  A1375 (-4.8A)
None
 1.40A 4bb2A-2v95A:
30.2
4bb2B-2v95A:
undetectable		 4bb2A-2v95A:
56.80
4bb2B-2v95A:
5.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4BB2_B_STRB1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 5hgc SERPIN
(Taeniopygia
guttata) 		5 / 11 ALA A  39
THR A 254
PHE A 256
ILE A 277
SER A 281
 None
HCY  A 501 ( 4.1A)
HCY  A 501 (-4.8A)
HCY  A 501 ( 4.2A)
HCY  A 501 (-3.0A)
 1.35A 4bb2A-5hgcA:
36.1
4bb2B-5hgcA:
undetectable		 4bb2A-5hgcA:
38.99
4bb2B-5hgcA:
5.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4C49_A_HCYA1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 2v95 CORTICOSTEROID-BINDI
NG GLOBULIN
(Rattus
norvegicus) 		8 / 12 ALA A  13
VAL A  17
GLN A 224
THR A 232
PHE A 234
ILE A 255
PHE A 357
TRP A 362
 HCY  A1375 (-3.6A)
HCY  A1375 ( 4.8A)
HCY  A1375 (-3.5A)
HCY  A1375 ( 4.2A)
HCY  A1375 (-4.8A)
None
HCY  A1375 ( 4.1A)
HCY  A1375 (-3.8A)
 0.68A 4c49A-2v95A:
39.0		 4c49A-2v95A:
61.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4C49_B_HCYB1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 2v95 CORTICOSTEROID-BINDI
NG GLOBULIN
(Rattus
norvegicus) 		7 / 12 VAL A  17
GLN A 224
THR A 232
PHE A 234
ARG A 252
ILE A 255
PHE A 357
 HCY  A1375 ( 4.8A)
HCY  A1375 (-3.5A)
HCY  A1375 ( 4.2A)
HCY  A1375 (-4.8A)
HCY  A1375 (-4.9A)
None
HCY  A1375 ( 4.1A)
 0.74A 4c49B-2v95A:
39.0		 4c49B-2v95A:
61.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4C49_B_HCYB1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 2v95 CORTICOSTEROID-BINDI
NG GLOBULIN
(Rattus
norvegicus) 		7 / 12 VAL A  17
GLN A 224
THR A 232
PHE A 234
ILE A 255
PHE A 357
TRP A 362
 HCY  A1375 ( 4.8A)
HCY  A1375 (-3.5A)
HCY  A1375 ( 4.2A)
HCY  A1375 (-4.8A)
None
HCY  A1375 ( 4.1A)
HCY  A1375 (-3.8A)
 0.52A 4c49B-2v95A:
39.0		 4c49B-2v95A:
61.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4C49_C_HCYC1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 2v95 CORTICOSTEROID-BINDI
NG GLOBULIN
(Rattus
norvegicus) 		8 / 12 VAL A  17
GLN A 224
THR A 232
PHE A 234
ARG A 252
ILE A 255
PHE A 357
TRP A 362
 HCY  A1375 ( 4.8A)
HCY  A1375 (-3.5A)
HCY  A1375 ( 4.2A)
HCY  A1375 (-4.8A)
HCY  A1375 (-4.9A)
None
HCY  A1375 ( 4.1A)
HCY  A1375 (-3.8A)
 0.65A 4c49C-2v95A:
39.2		 4c49C-2v95A:
61.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4C49_D_HCYD1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 2v95 CORTICOSTEROID-BINDI
NG GLOBULIN
(Rattus
norvegicus) 		7 / 12 VAL A  17
GLN A 224
THR A 232
PHE A 234
ARG A 252
ILE A 255
PHE A 357
 HCY  A1375 ( 4.8A)
HCY  A1375 (-3.5A)
HCY  A1375 ( 4.2A)
HCY  A1375 (-4.8A)
HCY  A1375 (-4.9A)
None
HCY  A1375 ( 4.1A)
 0.69A 4c49D-2v95A:
37.5		 4c49D-2v95A:
61.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4C49_D_HCYD1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 2v95 CORTICOSTEROID-BINDI
NG GLOBULIN
(Rattus
norvegicus) 		7 / 12 VAL A  17
GLN A 224
THR A 232
PHE A 234
ILE A 255
PHE A 357
TRP A 362
 HCY  A1375 ( 4.8A)
HCY  A1375 (-3.5A)
HCY  A1375 ( 4.2A)
HCY  A1375 (-4.8A)
None
HCY  A1375 ( 4.1A)
HCY  A1375 (-3.8A)
 0.57A 4c49D-2v95A:
37.5		 4c49D-2v95A:
61.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZBR_A_ACTA608_0
(SERUM ALBUMIN)		 2v95 CORTICOSTEROID-BINDI
NG GLOBULIN
(Rattus
norvegicus) 		3 / 3 LYS A 359
ARG A  10
HIS A   9
 HCY  A1375 (-4.8A)
None
None
 1.14A 4zbrA-2v95A:
undetectable		 4zbrA-2v95A:
20.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HGC_A_HCYA501_1
(SERPIN)		 2v95 CORTICOSTEROID-BINDI
NG GLOBULIN
(Rattus
norvegicus) 		5 / 12 PRO A  14
THR A 232
PHE A 234
ILE A 255
PHE A 357
 HCY  A1375 (-3.4A)
HCY  A1375 ( 4.2A)
HCY  A1375 (-4.8A)
None
HCY  A1375 ( 4.1A)
 0.54A 5hgcA-2v95A:
22.9		 5hgcA-2v95A:
39.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW8_F_FK5F201_1
(FK506-BINDING
PROTEIN 1)		 5hgc SERPIN
(Taeniopygia
guttata) 		5 / 12 ARG A 246
ILE A 277
ILE A 379
PHE A  40
ILE A 393
 HCY  A 501 (-3.0A)
HCY  A 501 ( 4.2A)
None
None
None
 1.02A 5hw8B-5hgcA:
undetectable
5hw8F-5hgcA:
undetectable
5hw8G-5hgcA:
undetectable		 5hw8B-5hgcA:
17.07
5hw8F-5hgcA:
17.07
5hw8G-5hgcA:
17.07