SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'HC9'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1Y0X_X_T44X500_1 (THYROID HORMONE RECEPTOR BETA-1)	3mzs	CHOLESTEROL SIDE-CHAIN CLEAVAGE ENZYME (Bos taurus)	5 / 12	ILE A 235 ALA A 286 ILE A 85 HIS A 92 PHE A 236	None HC9 A 501 ( 4.1A) None None None	1.38A	1y0xX-3mzsA: 1.9	1y0xX-3mzsA: 21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3FW1_A_STIA233_1 (RIBOSYLDIHYDRONICOTI NAMIDE DEHYDROGENASE [QUINONE])	3mzs	CHOLESTEROL SIDE-CHAIN CLEAVAGE ENZYME (Bos taurus)	5 / 10	PHE A 203 GLY A 288 GLY A 287 GLU A 432 ILE A 428	HC9 A 501 (-4.6A) HEM A 500 (-3.6A) HEM A 500 (-3.4A) None None	1.24A	3fw1A-3mzsA: undetectable	3fw1A-3mzsA: 17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3WEL_A_ACRA1001_2 (ALPHA-GLUCOSIDASE)	3mzs	CHOLESTEROL SIDE-CHAIN CLEAVAGE ENZYME (Bos taurus)	4 / 6	ILE A 196 ILE A 85 TRP A 88 MET A 202	None None HC9 A 501 (-4.7A) None	1.29A	3welA-3mzsA: undetectable	3welA-3mzsA: 19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5VKQ_C_PCFC1803_0 (NO MECHANORECEPTOR POTENTIAL C ISOFORM L)	3mzs	CHOLESTEROL SIDE-CHAIN CLEAVAGE ENZYME (Bos taurus)	4 / 8	SER A 206 PHE A 458 VAL A 199 ILE A 351	None HC9 A 501 (-4.8A) None HEM A 500 ( 4.4A)	1.06A	5vkqB-3mzsA: 2.0 5vkqC-3mzsA: undetectable	5vkqB-3mzsA: 14.66 5vkqC-3mzsA: 14.66

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1Y0X_X_T44X500_1","THYROID HORMONE RECEPTOR BETA-1","3mzs","CHOLESTEROL SIDE-CHAIN CLEAVAGE ENZYME","Bos taurus",5,"ILE A 235;ALA A 286;ILE A  85;HIS A  92;PHE A 236","None;HC9 A 501 ( 4.1A);None;None;None","1.38A","1y0xX-3mzsA:1.9",null],["3FW1_A_STIA233_1","RIBOSYLDIHYDRONICOTINAMIDE DEHYDROGENASE [QUINONE]","3mzs","CHOLESTEROL SIDE-CHAIN CLEAVAGE ENZYME","Bos taurus",5,"PHE A 203;GLY A 288;GLY A 287;GLU A 432;ILE A 428","HC9 A 501 (-4.6A);HEM A 500 (-3.6A);HEM A 500 (-3.4A);None;None","1.24A","3fw1A-3mzsA:undetectable","1y0xX-3mzsA:21.69"],["3WEL_A_ACRA1001_2","ALPHA-GLUCOSIDASE","3mzs","CHOLESTEROL SIDE-CHAIN CLEAVAGE ENZYME","Bos taurus",4,"ILE A 196;ILE A  85;TRP A  88;MET A 202","None;None;HC9 A 501 (-4.7A);None","1.29A","3welA-3mzsA:undetectable","3fw1A-3mzsA:17.89"],["5VKQ_C_PCFC1803_0","NO MECHANORECEPTOR POTENTIAL C ISOFORM L","3mzs","CHOLESTEROL SIDE-CHAIN CLEAVAGE ENZYME","Bos taurus",4,"SER A 206;PHE A 458;VAL A 199;ILE A 351","None;HC9 A 501 (-4.8A);None;HEM A 500 ( 4.4A)","1.06A","5vkqB-3mzsA:2.0;5vkqC-3mzsA:undetectable","3welA-3mzsA:19.34"]]