SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'HC4'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AX9_A_EDRA999_1
(ACETYLCHOLINESTERASE)		 3a5r BENZALACETONE
SYNTHASE
(Rheum
palmatum) 		4 / 8 GLY A 156
GLU A 185
SER A 331
PHE A 258
 HC4  A 400 (-3.6A)
None
HC4  A 400 ( 4.4A)
HC4  A 400 ( 3.9A)
 0.99A 1ax9A-3a5rA:
undetectable		 1ax9A-3a5rA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T87_A_CAMA1422_0
(CYTOCHROME P450-CAM)		 1odv PHOTOACTIVE YELLOW
PROTEIN
(Halorhodospira
halophila) 		4 / 7 PHE A  92
THR A  70
VAL A 120
VAL A 105
 None
HC4  A 126 ( 4.7A)
None
None
 1.07A 1t87A-1odvA:
undetectable		 1t87A-1odvA:
13.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XLX_A_CIOA101_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 5mov CASEIN KINASE II
SUBUNIT ALPHA
(Homo
sapiens) 		5 / 12 HIS A 154
LEU A  85
ILE A 174
MET A 163
PHE A 113
 None
None
HC4  A 401 ( 3.7A)
HC4  A 401 ( 4.0A)
HC4  A 401 (-3.4A)
 1.49A 1xlxA-5movA:
undetectable		 1xlxA-5movA:
24.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOM_A_CIOA603_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 5mov CASEIN KINASE II
SUBUNIT ALPHA
(Homo
sapiens) 		5 / 12 HIS A 154
LEU A  85
ILE A 174
MET A 163
PHE A 113
 None
None
HC4  A 401 ( 3.7A)
HC4  A 401 ( 4.0A)
HC4  A 401 (-3.4A)
 1.44A 1xomA-5movA:
undetectable		 1xomA-5movA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOM_B_CIOB601_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 5mov CASEIN KINASE II
SUBUNIT ALPHA
(Homo
sapiens) 		5 / 12 HIS A 154
LEU A  85
ILE A 174
MET A 163
PHE A 113
 None
None
HC4  A 401 ( 3.7A)
HC4  A 401 ( 4.0A)
HC4  A 401 (-3.4A)
 1.43A 1xomB-5movA:
undetectable		 1xomB-5movA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ACK_A_EDRA999_1
(ACETYLCHOLINESTERASE)		 3a5r BENZALACETONE
SYNTHASE
(Rheum
palmatum) 		4 / 7 GLY A 156
GLU A 185
SER A 331
PHE A 258
 HC4  A 400 (-3.6A)
None
HC4  A 400 ( 4.4A)
HC4  A 400 ( 3.9A)
 0.98A 2ackA-3a5rA:
undetectable		 2ackA-3a5rA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E5D_A_NCAA1501_0
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 1mzu PPR
(Rhodospirillum
centenum) 		4 / 7 PHE A  98
ALA A  67
ARG A  52
ASP A  97
 HC4  A 130 (-4.9A)
HC4  A 130 (-3.4A)
HC4  A 130 ( 3.9A)
None
 1.00A 2e5dA-1mzuA:
undetectable
2e5dB-1mzuA:
undetectable		 2e5dA-1mzuA:
12.55
2e5dB-1mzuA:
12.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E5D_B_NCAB1502_0
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 1mzu PPR
(Rhodospirillum
centenum) 		4 / 7 ASP A  97
PHE A  98
ALA A  67
ARG A  52
 None
HC4  A 130 (-4.9A)
HC4  A 130 (-3.4A)
HC4  A 130 ( 3.9A)
 1.00A 2e5dA-1mzuA:
undetectable
2e5dB-1mzuA:
undetectable		 2e5dA-1mzuA:
12.55
2e5dB-1mzuA:
12.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJ3_A_GBNA2414_1
(BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE)		 4eyo EXTRACELLULAR
LIGAND-BINDING
RECEPTOR
(Rhodopseudomonas
palustris) 		4 / 8 GLY A 247
THR A 224
ALA A 225
ALA A 226
 HC4  A 401 (-3.4A)
None
None
None
 0.58A 2ej3A-4eyoA:
undetectable		 2ej3A-4eyoA:
24.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EUF_B_LQQB401_1
(CELL DIVISION
PROTEIN KINASE 6)		 5mov CASEIN KINASE II
SUBUNIT ALPHA
(Homo
sapiens) 		6 / 12 VAL A  53
LYS A  68
PHE A 113
VAL A 116
ASN A 161
ASP A 175
 None
HC4  A 401 (-2.7A)
HC4  A 401 (-3.4A)
None
None
HC4  A 401 (-4.0A)
 0.61A 2eufB-5movA:
30.0		 2eufB-5movA:
29.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_A_MIXA539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 5mov CASEIN KINASE II
SUBUNIT ALPHA
(Homo
sapiens) 		7 / 12 LEU A  45
VAL A  53
ASP A 156
LYS A 158
ASN A 161
MET A 163
ASP A 175
 HC4  A 401 ( 4.8A)
None
None
None
None
HC4  A 401 ( 4.0A)
HC4  A 401 (-4.0A)
 0.88A 2fumA-5movA:
24.6		 2fumA-5movA:
25.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_D_MIXD3539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 5mov CASEIN KINASE II
SUBUNIT ALPHA
(Homo
sapiens) 		7 / 12 LEU A  45
GLY A  46
GLY A  48
VAL A  53
LYS A 158
ASN A 161
MET A 163
 HC4  A 401 ( 4.8A)
None
None
None
None
None
HC4  A 401 ( 4.0A)
 0.95A 2fumD-5movA:
23.0		 2fumD-5movA:
25.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IVU_A_ZD6A3015_0
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
PRECURSOR)		 5mov CASEIN KINASE II
SUBUNIT ALPHA
(Homo
sapiens) 		7 / 12 LEU A  45
GLY A  46
VAL A  53
LYS A  68
LEU A  85
LEU A 111
ASP A 175
 HC4  A 401 ( 4.8A)
None
None
HC4  A 401 (-2.7A)
None
None
HC4  A 401 (-4.0A)
 0.80A 2ivuA-5movA:
24.2		 2ivuA-5movA:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IVU_A_ZD6A3015_0
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
PRECURSOR)		 5mov CASEIN KINASE II
SUBUNIT ALPHA
(Homo
sapiens) 		7 / 12 LEU A  45
VAL A  53
LYS A  68
GLU A  81
LEU A  85
LEU A 111
ASP A 175
 HC4  A 401 ( 4.8A)
None
HC4  A 401 (-2.7A)
None
None
None
HC4  A 401 (-4.0A)
 0.92A 2ivuA-5movA:
24.2		 2ivuA-5movA:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKJ_D_CLMD1142_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 3a5r BENZALACETONE
SYNTHASE
(Rheum
palmatum) 		4 / 5 PRO A 265
PRO A 300
ILE A 207
GLY A 298
 None
None
HC4  A 400 ( 4.5A)
None
 1.13A 2jkjD-3a5rA:
undetectable		 2jkjD-3a5rA:
16.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKJ_F_CLMF1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 3a5r BENZALACETONE
SYNTHASE
(Rheum
palmatum) 		4 / 5 PRO A 265
PRO A 300
ILE A 207
GLY A 298
 None
None
HC4  A 400 ( 4.5A)
None
 1.14A 2jkjF-3a5rA:
undetectable		 2jkjF-3a5rA:
16.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZUH_A_CAMA422_0
(CAMPHOR
5-MONOOXYGENASE)		 1d7e PHOTOACTIVE YELLOW
PROTEIN
(Halorhodospira
halophila) 		4 / 6 PHE A  92
THR A  70
VAL A 120
VAL A 105
 None
HC4  A 126 ( 4.6A)
None
None
 1.09A 2zuhA-1d7eA:
undetectable		 2zuhA-1d7eA:
15.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZUH_A_CAMA422_0
(CAMPHOR
5-MONOOXYGENASE)		 1odv PHOTOACTIVE YELLOW
PROTEIN
(Halorhodospira
halophila) 		4 / 6 PHE A  92
THR A  70
VAL A 120
VAL A 105
 None
HC4  A 126 ( 4.7A)
None
None
 1.04A 2zuhA-1odvA:
undetectable		 2zuhA-1odvA:
13.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZUI_A_CAMA422_0
(CAMPHOR
5-MONOOXYGENASE)		 1odv PHOTOACTIVE YELLOW
PROTEIN
(Halorhodospira
halophila) 		4 / 6 PHE A  92
THR A  70
VAL A 120
VAL A 105
 None
HC4  A 126 ( 4.7A)
None
None
 1.08A 2zuiA-1odvA:
undetectable		 2zuiA-1odvA:
13.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_E_SVRE503_1
(PHOSPHOLIPASE A2)		 4eyo EXTRACELLULAR
LIGAND-BINDING
RECEPTOR
(Rhodopseudomonas
palustris) 		5 / 11 VAL A 148
LEU A 149
GLY A 146
ILE A 142
PRO A 139
 None
None
None
None
HC4  A 401 (-4.0A)
 1.35A 3bjwE-4eyoA:
undetectable		 3bjwE-4eyoA:
14.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G4L_B_ROFB902_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 5mov CASEIN KINASE II
SUBUNIT ALPHA
(Homo
sapiens) 		5 / 12 HIS A 154
LEU A  85
ILE A 174
MET A 163
PHE A 113
 None
None
HC4  A 401 ( 3.7A)
HC4  A 401 ( 4.0A)
HC4  A 401 (-3.4A)
 1.41A 3g4lB-5movA:
undetectable		 3g4lB-5movA:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N58_C_ADNC500_2
(ADENOSYLHOMOCYSTEINA
SE)		 3a5r BENZALACETONE
SYNTHASE
(Rheum
palmatum) 		4 / 5 LEU A 208
GLN A  91
THR A 187
HIS A 296
 HC4  A 400 ( 4.7A)
None
None
None
 1.18A 3n58C-3a5rA:
undetectable		 3n58C-3a5rA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9T_B_BEZB264_0
(ECHA1_1)		 1odv PHOTOACTIVE YELLOW
PROTEIN
(Halorhodospira
halophila) 		4 / 7 ILE A  39
LEU A  33
GLU A  46
ALA A  30
 None
None
HC4  A 126 (-3.5A)
None
 0.86A 3r9tB-1odvA:
undetectable		 3r9tB-1odvA:
15.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3WAR_A_NIOA401_1
(CASEIN KINASE II
SUBUNIT ALPHA)		 5mov CASEIN KINASE II
SUBUNIT ALPHA
(Homo
sapiens) 		8 / 8 VAL A  53
VAL A  66
LYS A  68
ILE A  95
PHE A 113
MET A 163
ILE A 174
ASP A 175
 None
HC4  A 401 (-4.4A)
HC4  A 401 (-2.7A)
HC4  A 401 ( 4.5A)
HC4  A 401 (-3.4A)
HC4  A 401 ( 4.0A)
HC4  A 401 ( 3.7A)
HC4  A 401 (-4.0A)
 0.28A 3warA-5movA:
41.3		 3warA-5movA:
96.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IQQ_A_D16A402_1
(THYMIDYLATE SYNTHASE)		 1d7e PHOTOACTIVE YELLOW
PROTEIN
(Halorhodospira
halophila) 		5 / 7 TYR A  42
ILE A  31
ASP A  34
GLY A  37
PHE A  62
 HC4  A 126 (-4.2A)
None
None
None
HC4  A 126 (-4.7A)
 1.47A 4iqqA-1d7eA:
undetectable		 4iqqA-1d7eA:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IQQ_A_D16A402_1
(THYMIDYLATE SYNTHASE)		 1mzu PPR
(Rhodospirillum
centenum) 		5 / 7 TYR A  42
ILE A  31
ASP A  34
GLY A  37
PHE A  62
 HC4  A 130 (-4.6A)
None
None
None
None
 1.49A 4iqqA-1mzuA:
undetectable		 4iqqA-1mzuA:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IQQ_A_D16A402_1
(THYMIDYLATE SYNTHASE)		 1odv PHOTOACTIVE YELLOW
PROTEIN
(Halorhodospira
halophila) 		5 / 7 TYR A  42
ILE A  31
ASP A  34
GLY A  37
PHE A  62
 HC4  A 126 (-4.2A)
None
None
None
HC4  A 126 ( 4.9A)
 1.49A 4iqqA-1odvA:
undetectable		 4iqqA-1odvA:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IQQ_D_D16D402_1
(THYMIDYLATE SYNTHASE)		 1d7e PHOTOACTIVE YELLOW
PROTEIN
(Halorhodospira
halophila) 		5 / 8 TYR A  42
ILE A  31
ASP A  34
GLY A  37
PHE A  62
 HC4  A 126 (-4.2A)
None
None
None
HC4  A 126 (-4.7A)
 1.46A 4iqqD-1d7eA:
0.5		 4iqqD-1d7eA:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IQQ_D_D16D402_1
(THYMIDYLATE SYNTHASE)		 1mzu PPR
(Rhodospirillum
centenum) 		5 / 8 TYR A  42
ILE A  31
ASP A  34
GLY A  37
PHE A  62
 HC4  A 130 (-4.6A)
None
None
None
None
 1.49A 4iqqD-1mzuA:
undetectable		 4iqqD-1mzuA:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IQQ_D_D16D402_1
(THYMIDYLATE SYNTHASE)		 1odv PHOTOACTIVE YELLOW
PROTEIN
(Halorhodospira
halophila) 		5 / 8 TYR A  42
ILE A  31
ASP A  34
GLY A  37
PHE A  62
 HC4  A 126 (-4.2A)
None
None
None
HC4  A 126 ( 4.9A)
 1.48A 4iqqD-1odvA:
undetectable		 4iqqD-1odvA:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C6P_A_4YHA601_1
(PROTEIN C)		 4eyo EXTRACELLULAR
LIGAND-BINDING
RECEPTOR
(Rhodopseudomonas
palustris) 		4 / 6 ALA A 225
SER A 222
SER A 167
ASP A 199
 None
HC4  A 401 (-2.4A)
None
None
 0.98A 5c6pA-4eyoA:
undetectable		 5c6pA-4eyoA:
23.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GWX_A_SAMA301_0
(GLYCINE SARCOSINE
N-METHYLTRANSFERASE)		 4eyo EXTRACELLULAR
LIGAND-BINDING
RECEPTOR
(Rhodopseudomonas
palustris) 		5 / 12 ALA A 249
GLY A 223
SER A 222
GLY A 269
HIS A 309
 None
None
HC4  A 401 (-2.4A)
None
HC4  A 401 (-3.8A)
 1.03A 5gwxA-4eyoA:
4.4		 5gwxA-4eyoA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NJV_D_SAMD301_0
(NS5)		 3a5r BENZALACETONE
SYNTHASE
(Rheum
palmatum) 		5 / 12 GLY A 156
GLY A 365
GLU A 373
VAL A 306
ILE A 268
 HC4  A 400 (-3.6A)
None
None
None
None
 1.02A 5njvD-3a5rA:
undetectable		 5njvD-3a5rA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOP_B_C2FB3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 3a5r BENZALACETONE
SYNTHASE
(Rheum
palmatum) 		5 / 12 GLY A 365
LEU A 260
GLY A 299
ASN A 329
ILE A 302
 None
HC4  A 400 ( 4.4A)
None
HC4  A 400 (-4.0A)
None
 1.13A 5vopB-3a5rA:
undetectable		 5vopB-3a5rA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X66_A_MTXA402_1
(THYMIDYLATE SYNTHASE)		 1d7e PHOTOACTIVE YELLOW
PROTEIN
(Halorhodospira
halophila) 		5 / 12 ILE A  31
ASP A  34
GLY A  37
PHE A  62
ASP A  53
 None
None
None
HC4  A 126 (-4.7A)
None
 1.11A 5x66A-1d7eA:
undetectable
5x66B-1d7eA:
0.0		 5x66A-1d7eA:
20.45
5x66B-1d7eA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIP_A_HFGA1003_0
(PROLYL-TRNA
SYNTHETASE, PUTATIVE)		 4eyo EXTRACELLULAR
LIGAND-BINDING
RECEPTOR
(Rhodopseudomonas
palustris) 		5 / 12 PRO A 103
THR A 102
ARG A 197
THR A 245
GLY A 247
 None
HC4  A 401 (-3.7A)
HC4  A 401 (-2.9A)
None
HC4  A 401 (-3.4A)
 1.08A 5xipA-4eyoA:
3.6		 5xipA-4eyoA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y9M_X_NIOX401_1
(CASEIN KINASE II
SUBUNIT ALPHA')		 5mov CASEIN KINASE II
SUBUNIT ALPHA
(Homo
sapiens) 		5 / 8 LEU A  45
VAL A  53
VAL A  66
LYS A  68
ASP A 175
 HC4  A 401 ( 4.8A)
None
HC4  A 401 (-4.4A)
HC4  A 401 (-2.7A)
HC4  A 401 (-4.0A)
 0.74A 5y9mX-5movA:
48.4		 5y9mX-5movA:
25.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y9M_X_NIOX401_1
(CASEIN KINASE II
SUBUNIT ALPHA')		 5mov CASEIN KINASE II
SUBUNIT ALPHA
(Homo
sapiens) 		6 / 8 VAL A  53
VAL A  66
LYS A  68
MET A 163
ILE A 174
ASP A 175
 None
HC4  A 401 (-4.4A)
HC4  A 401 (-2.7A)
HC4  A 401 ( 4.0A)
HC4  A 401 ( 3.7A)
HC4  A 401 (-4.0A)
 0.67A 5y9mX-5movA:
48.4		 5y9mX-5movA:
25.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y9M_X_NIOX401_1
(CASEIN KINASE II
SUBUNIT ALPHA')		 5mov CASEIN KINASE II
SUBUNIT ALPHA
(Homo
sapiens) 		6 / 8 VAL A  53
VAL A  66
LYS A  68
PHE A 113
ILE A 174
ASP A 175
 None
HC4  A 401 (-4.4A)
HC4  A 401 (-2.7A)
HC4  A 401 (-3.4A)
HC4  A 401 ( 3.7A)
HC4  A 401 (-4.0A)
 0.25A 5y9mX-5movA:
48.4		 5y9mX-5movA:
25.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YF9_B_NIOB401_1
(CASEIN KINASE II
SUBUNIT ALPHA')		 5mov CASEIN KINASE II
SUBUNIT ALPHA
(Homo
sapiens) 		5 / 7 VAL A  53
VAL A  66
LYS A  68
PHE A 113
ILE A  95
 None
HC4  A 401 (-4.4A)
HC4  A 401 (-2.7A)
HC4  A 401 (-3.4A)
HC4  A 401 ( 4.5A)
 1.39A 5yf9B-5movA:
34.8		 5yf9B-5movA:
25.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YF9_B_NIOB401_1
(CASEIN KINASE II
SUBUNIT ALPHA')		 5mov CASEIN KINASE II
SUBUNIT ALPHA
(Homo
sapiens) 		7 / 7 VAL A  53
VAL A  66
LYS A  68
PHE A 113
MET A 163
ILE A 174
ASP A 175
 None
HC4  A 401 (-4.4A)
HC4  A 401 (-2.7A)
HC4  A 401 (-3.4A)
HC4  A 401 ( 4.0A)
HC4  A 401 ( 3.7A)
HC4  A 401 (-4.0A)
 0.68A 5yf9B-5movA:
34.8		 5yf9B-5movA:
25.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YF9_X_NIOX401_1
(CASEIN KINASE II
SUBUNIT ALPHA')		 5mov CASEIN KINASE II
SUBUNIT ALPHA
(Homo
sapiens) 		6 / 9 LEU A  45
VAL A  53
VAL A  66
LYS A  68
PHE A 113
ASP A 175
 HC4  A 401 ( 4.8A)
None
HC4  A 401 (-4.4A)
HC4  A 401 (-2.7A)
HC4  A 401 (-3.4A)
HC4  A 401 (-4.0A)
 0.69A 5yf9X-5movA:
48.2		 5yf9X-5movA:
25.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YF9_X_NIOX401_1
(CASEIN KINASE II
SUBUNIT ALPHA')		 5mov CASEIN KINASE II
SUBUNIT ALPHA
(Homo
sapiens) 		5 / 9 LEU A  45
VAL A  66
LYS A  68
ILE A 174
PHE A 113
 HC4  A 401 ( 4.8A)
HC4  A 401 (-4.4A)
HC4  A 401 (-2.7A)
HC4  A 401 ( 3.7A)
HC4  A 401 (-3.4A)
 1.24A 5yf9X-5movA:
48.2		 5yf9X-5movA:
25.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YF9_X_NIOX401_1
(CASEIN KINASE II
SUBUNIT ALPHA')		 5mov CASEIN KINASE II
SUBUNIT ALPHA
(Homo
sapiens) 		7 / 9 VAL A  53
VAL A  66
LYS A  68
ILE A  95
PHE A 113
ILE A 174
ASP A 175
 None
HC4  A 401 (-4.4A)
HC4  A 401 (-2.7A)
HC4  A 401 ( 4.5A)
HC4  A 401 (-3.4A)
HC4  A 401 ( 3.7A)
HC4  A 401 (-4.0A)
 0.27A 5yf9X-5movA:
48.2		 5yf9X-5movA:
25.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YF9_X_NIOX401_1
(CASEIN KINASE II
SUBUNIT ALPHA')		 5mov CASEIN KINASE II
SUBUNIT ALPHA
(Homo
sapiens) 		7 / 9 VAL A  53
VAL A  66
LYS A  68
PHE A 113
MET A 163
ILE A 174
ASP A 175
 None
HC4  A 401 (-4.4A)
HC4  A 401 (-2.7A)
HC4  A 401 (-3.4A)
HC4  A 401 ( 4.0A)
HC4  A 401 ( 3.7A)
HC4  A 401 (-4.0A)
 0.64A 5yf9X-5movA:
48.2		 5yf9X-5movA:
25.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YWM_X_NIOX403_0
(CASEIN KINASE II
SUBUNIT ALPHA')		 5mov CASEIN KINASE II
SUBUNIT ALPHA
(Homo
sapiens) 		7 / 7 VAL A  53
VAL A  66
LYS A  68
ILE A  95
PHE A 113
ILE A 174
ASP A 175
 None
HC4  A 401 (-4.4A)
HC4  A 401 (-2.7A)
HC4  A 401 ( 4.5A)
HC4  A 401 (-3.4A)
HC4  A 401 ( 3.7A)
HC4  A 401 (-4.0A)
 0.33A 5ywmX-5movA:
47.3		 5ywmX-5movA:
25.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		 5mov CASEIN KINASE II
SUBUNIT ALPHA
(Homo
sapiens) 		3 / 3 LYS A  77
LEU A  85
ASP A 175
 None
None
HC4  A 401 (-4.0A)
 0.89A 5zv2A-5movA:
20.1		 5zv2A-5movA:
12.93