SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'HC3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3BJW_F_SVRF509_2 (PHOSPHOLIPASE A2)	3gkj	NIEMANN-PICK C1 PROTEIN (Homo sapiens)	4 / 8	ASN A 198 LYS A 196 PRO A 207 PHE A 209	HC3 A 253 ( 3.8A) None None None	1.39A	3bjwD-3gkjA: undetectable	3bjwD-3gkjA: 21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4UUU_A_SAMA1546_0 (CYSTATHIONINE BETA-SYNTHASE)	6bym	STEROL-BINDING PROTEIN (Saccharomyces cerevisiae)	5 / 11	LEU A 104 GLN A 178 VAL A 136 THR A 156 ILE A 155	HC3 A 301 ( 4.6A) HC3 A 301 ( 3.4A) HC3 A 301 ( 4.2A) None None	1.30A	4uuuA-6bymA: undetectable 4uuuB-6bymA: undetectable	4uuuA-6bymA: undetectable 4uuuB-6bymA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4UUU_B_SAMB1548_0 (CYSTATHIONINE BETA-SYNTHASE)	6bym	STEROL-BINDING PROTEIN (Saccharomyces cerevisiae)	5 / 11	LEU A 104 GLN A 178 VAL A 136 THR A 156 ILE A 155	HC3 A 301 ( 4.6A) HC3 A 301 ( 3.4A) HC3 A 301 ( 4.2A) None None	1.32A	4uuuB-6bymA: undetectable	4uuuB-6bymA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5HGC_A_HCYA501_1 (SERPIN)	6bym	STEROL-BINDING PROTEIN (Saccharomyces cerevisiae)	5 / 12	LYS A 167 ILE A 170 SER A 174 PHE A 134 ASN A 159	None HC3 A 301 ( 4.1A) HC3 A 301 ( 3.3A) HC3 A 301 ( 4.6A) None	1.30A	5hgcA-6bymA: undetectable	5hgcA-6bymA: 11.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5JM4_B_BEZB301_0 (14-3-3 PROTEIN ZETA/DELTA)	6bym	STEROL-BINDING PROTEIN (Saccharomyces cerevisiae)	4 / 4	PHE A 73 ILE A 108 GLN A 121 ARG A 83	None None HC3 A 301 (-2.5A) None	1.43A	5jm4B-6bymA: undetectable	5jm4B-6bymA: undetectable

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["3BJW_F_SVRF509_2","PHOSPHOLIPASE A2;PHOSPHOLIPASE A2","3gkj","NIEMANN-PICK C1 PROTEIN","Homo sapiens",4,"ASN A 198;LYS A 196;PRO A 207;PHE A 209","HC3 A 253 ( 3.8A);None;None;None","1.39A","3bjwD-3gkjA:undetectable",null],["4UUU_A_SAMA1546_0","CYSTATHIONINE BETA-SYNTHASE","6bym","STEROL-BINDING PROTEIN","Saccharomyces cerevisiae",5,"LEU A 104;GLN A 178;VAL A 136;THR A 156;ILE A 155","HC3 A 301 ( 4.6A);HC3 A 301 ( 3.4A);HC3 A 301 ( 4.2A);None;None","1.30A","4uuuA-6bymA:undetectable;4uuuB-6bymA:undetectable","3bjwD-3gkjA:21.10"],["4UUU_B_SAMB1548_0","CYSTATHIONINE BETA-SYNTHASE","6bym","STEROL-BINDING PROTEIN","Saccharomyces cerevisiae",5,"LEU A 104;GLN A 178;VAL A 136;THR A 156;ILE A 155","HC3 A 301 ( 4.6A);HC3 A 301 ( 3.4A);HC3 A 301 ( 4.2A);None;None","1.32A","4uuuB-6bymA:undetectable","4uuuA-6bymA:undetectable;4uuuB-6bymA:undetectable"],["5HGC_A_HCYA501_1","SERPIN","6bym","STEROL-BINDING PROTEIN","Saccharomyces cerevisiae",5,"LYS A 167;ILE A 170;SER A 174;PHE A 134;ASN A 159","None;HC3 A 301 ( 4.1A);HC3 A 301 ( 3.3A);HC3 A 301 ( 4.6A);None","1.30A","5hgcA-6bymA:undetectable","4uuuB-6bymA:undetectable"],["5JM4_B_BEZB301_0","14-3-3 PROTEIN ZETA\/DELTA","6bym","STEROL-BINDING PROTEIN","Saccharomyces cerevisiae",4,"PHE A  73;ILE A 108;GLN A 121;ARG A  83","None;None;HC3 A 301 (-2.5A);None","1.43A","5jm4B-6bymA:undetectable","5hgcA-6bymA:11.70"]]