SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'HC1'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P93_D_DEXD4999_1
(GLUCOCORTICOID
RECEPTOR)		 1feh PROTEIN (PERIPLASMIC
HYDROGENASE 1)
(Clostridium
pasteurianum) 		5 / 12 GLY A 421
MET A 497
THR A 275
ILE A 276
PHE A 417
 None
HC1  A 580 (-3.3A)
None
None
HC1  A 580 (-4.3A)
 1.29A 1p93D-1fehA:
undetectable		 1p93D-1fehA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DXR_A_SORA1002_0
(LACTOTRANSFERRIN)		 1feh PROTEIN (PERIPLASMIC
HYDROGENASE 1)
(Clostridium
pasteurianum) 		3 / 3 THR A 250
PRO A 231
TYR A 410
 None
HC1  A 580 (-3.5A)
None
 0.93A 2dxrA-1fehA:
undetectable		 2dxrA-1fehA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7H_B_SAMB530_0
(TYPE I RESTRICTION
ENZYME ECOKI M
PROTEIN)		 1feh PROTEIN (PERIPLASMIC
HYDROGENASE 1)
(Clostridium
pasteurianum) 		5 / 12 THR A 351
ILE A 375
GLY A 271
GLY A 329
PRO A 231
 None
None
None
None
HC1  A 580 (-3.5A)
 1.04A 2y7hB-1fehA:
undetectable		 2y7hB-1fehA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7H_C_SAMC530_0
(TYPE I RESTRICTION
ENZYME ECOKI M
PROTEIN)		 1feh PROTEIN (PERIPLASMIC
HYDROGENASE 1)
(Clostridium
pasteurianum) 		5 / 12 THR A 351
ILE A 375
GLY A 271
GLY A 329
PRO A 231
 None
None
None
None
HC1  A 580 (-3.5A)
 1.05A 2y7hC-1fehA:
undetectable		 2y7hC-1fehA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PRS_A_RITA1001_1
(ENDOTHIAPEPSIN)		 1feh PROTEIN (PERIPLASMIC
HYDROGENASE 1)
(Clostridium
pasteurianum) 		5 / 10 ILE A 268
ASP A 267
ALA A 230
ILE A 198
ILE A 522
 HC1  A 580 ( 4.8A)
None
HC1  A 580 (-3.1A)
None
None
 1.16A 3prsA-1fehA:
undetectable		 3prsA-1fehA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MBS_B_MRVB1101_2
(CHIMERA PROTEIN OF
C-C CHEMOKINE
RECEPTOR TYPE 5 AND
RUBREDOXIN)		 1feh PROTEIN (PERIPLASMIC
HYDROGENASE 1)
(Clostridium
pasteurianum) 		4 / 5 TYR A 410
LEU A 260
THR A 351
MET A 353
 None
None
None
HC1  A 580 (-3.1A)
 1.39A 4mbsB-1fehA:
0.0		 4mbsB-1fehA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R1Z_B_AERB601_1
(CYP17A1 PROTEIN)		 1feh PROTEIN (PERIPLASMIC
HYDROGENASE 1)
(Clostridium
pasteurianum) 		4 / 7 ALA A 272
GLY A 422
GLU A 425
SER A 430
 HC1  A 580 (-3.6A)
None
None
None
 0.77A 4r1zB-1fehA:
undetectable		 4r1zB-1fehA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODI_A_ACTA701_0
(HETERODISULFIDE
REDUCTASE, SUBUNIT A)		 1feh PROTEIN (PERIPLASMIC
HYDROGENASE 1)
(Clostridium
pasteurianum) 		3 / 3 LYS A 358
LYS A 322
SER A 323
 HC1  A 580 (-2.8A)
None
HC1  A 580 ( 3.8A)
 0.93A 5odiA-1fehA:
5.6		 5odiA-1fehA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_H_PCFH604_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 8
CYTOCHROME C OXIDASE
POLYPEPTIDE 5A,
MITOCHONDRIAL)		 1feh PROTEIN (PERIPLASMIC
HYDROGENASE 1)
(Clostridium
pasteurianum) 		5 / 8 GLY A 507
VAL A 512
GLY A 418
SER A 232
ALA A 235
 None
None
HC1  A 580 ( 3.8A)
HC1  A 580 (-2.8A)
None
 1.26A 6hu9H-1fehA:
undetectable
6hu9e-1fehA:
0.7		 6hu9H-1fehA:
10.71
6hu9e-1fehA:
12.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_H_PCFH604_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 8
CYTOCHROME C OXIDASE
POLYPEPTIDE 5A,
MITOCHONDRIAL)		 1feh PROTEIN (PERIPLASMIC
HYDROGENASE 1)
(Clostridium
pasteurianum) 		5 / 8 GLY A 508
VAL A 512
GLY A 418
SER A 232
ALA A 235
 None
None
HC1  A 580 ( 3.8A)
HC1  A 580 (-2.8A)
None
 1.28A 6hu9H-1fehA:
undetectable
6hu9e-1fehA:
0.7		 6hu9H-1fehA:
10.71
6hu9e-1fehA:
12.37