SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'HBI'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1AO8_A_MTXA170_1
(DIHYDROFOLATE
REDUCTASE)		 1dr6 DIHYDROFOLATE
REDUCTASE
(Gallus
gallus) 		5 / 12 ALA A   9
PHE A  34
THR A  56
SER A  59
ARG A  70
 HBI  A 198 ( 3.6A)
HBI  A 198 (-4.1A)
NAP  A 191 (-3.5A)
NAP  A 191 ( 4.1A)
None
 0.87A 1ao8A-1dr6A:
19.4		 1ao8A-1dr6A:
32.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1AO8_A_MTXA170_1
(DIHYDROFOLATE
REDUCTASE)		 1dr6 DIHYDROFOLATE
REDUCTASE
(Gallus
gallus) 		5 / 12 ALA A   9
PHE A  34
THR A  56
SER A  59
THR A 136
 HBI  A 198 ( 3.6A)
HBI  A 198 (-4.1A)
NAP  A 191 (-3.5A)
NAP  A 191 ( 4.1A)
HBI  A 198 ( 4.5A)
 0.67A 1ao8A-1dr6A:
19.4		 1ao8A-1dr6A:
32.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1AO8_A_MTXA170_1
(DIHYDROFOLATE
REDUCTASE)		 1dr6 DIHYDROFOLATE
REDUCTASE
(Gallus
gallus) 		5 / 12 ALA A   9
THR A  56
SER A  59
LEU A  67
ARG A  70
 HBI  A 198 ( 3.6A)
NAP  A 191 (-3.5A)
NAP  A 191 ( 4.1A)
None
None
 0.94A 1ao8A-1dr6A:
19.4		 1ao8A-1dr6A:
32.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1AO8_A_MTXA170_1
(DIHYDROFOLATE
REDUCTASE)		 1dr6 DIHYDROFOLATE
REDUCTASE
(Gallus
gallus) 		5 / 12 ALA A   9
THR A  56
SER A  59
LEU A  67
THR A 136
 HBI  A 198 ( 3.6A)
NAP  A 191 (-3.5A)
NAP  A 191 ( 4.1A)
None
HBI  A 198 ( 4.5A)
 0.88A 1ao8A-1dr6A:
19.4		 1ao8A-1dr6A:
32.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1BZF_A_TMQA170_1
(DIHYDROFOLATE
REDUCTASE)		 1dr6 DIHYDROFOLATE
REDUCTASE
(Gallus
gallus) 		5 / 12 ALA A   9
LEU A  22
PHE A  34
THR A  56
THR A 136
 HBI  A 198 ( 3.6A)
NAP  A 191 ( 4.7A)
HBI  A 198 (-4.1A)
NAP  A 191 (-3.5A)
HBI  A 198 ( 4.5A)
 0.98A 1bzfA-1dr6A:
19.7		 1bzfA-1dr6A:
32.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1BZF_A_TMQA170_1
(DIHYDROFOLATE
REDUCTASE)		 1dr6 DIHYDROFOLATE
REDUCTASE
(Gallus
gallus) 		5 / 12 ALA A   9
PHE A  34
THR A  56
LEU A  67
THR A 136
 HBI  A 198 ( 3.6A)
HBI  A 198 (-4.1A)
NAP  A 191 (-3.5A)
None
HBI  A 198 ( 4.5A)
 0.84A 1bzfA-1dr6A:
19.7		 1bzfA-1dr6A:
32.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1CD2_A_FOLA307_0
(DIHYDROFOLATE
REDUCTASE)		 1dr6 DIHYDROFOLATE
REDUCTASE
(Gallus
gallus) 		8 / 12 ILE A   7
ALA A   9
LEU A  22
PHE A  34
THR A  56
LEU A  67
TYR A 121
THR A 136
 HBI  A 198 (-4.1A)
HBI  A 198 ( 3.6A)
NAP  A 191 ( 4.7A)
HBI  A 198 (-4.1A)
NAP  A 191 (-3.5A)
None
None
HBI  A 198 ( 4.5A)
 0.51A 1cd2A-1dr6A:
25.4		 1cd2A-1dr6A:
39.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1CD2_A_FOLA307_0
(DIHYDROFOLATE
REDUCTASE)		 1dr6 DIHYDROFOLATE
REDUCTASE
(Gallus
gallus) 		8 / 12 ILE A   7
ALA A   9
PHE A  34
THR A  56
PRO A  61
LEU A  67
TYR A 121
THR A 136
 HBI  A 198 (-4.1A)
HBI  A 198 ( 3.6A)
HBI  A 198 (-4.1A)
NAP  A 191 (-3.5A)
None
None
None
HBI  A 198 ( 4.5A)
 0.60A 1cd2A-1dr6A:
25.4		 1cd2A-1dr6A:
39.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D1G_A_MTXA171_1
(DIHYDROFOLATE
REDUCTASE)		 1dr6 DIHYDROFOLATE
REDUCTASE
(Gallus
gallus) 		5 / 12 ALA A   9
ILE A  60
LEU A  67
ARG A  70
THR A 136
 HBI  A 198 ( 3.6A)
None
None
None
HBI  A 198 ( 4.5A)
 0.63A 1d1gA-1dr6A:
16.7		 1d1gA-1dr6A:
27.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D1G_B_MTXB171_1
(DIHYDROFOLATE
REDUCTASE)		 1dr6 DIHYDROFOLATE
REDUCTASE
(Gallus
gallus) 		5 / 12 ALA A   9
ILE A  60
LEU A  67
ARG A  70
THR A 136
 HBI  A 198 ( 3.6A)
None
None
None
HBI  A 198 ( 4.5A)
 0.73A 1d1gB-1dr6A:
16.8		 1d1gB-1dr6A:
27.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DDR_A_MTXA200_1
(DIHYDROFOLATE
REDUCTASE)		 1dr6 DIHYDROFOLATE
REDUCTASE
(Gallus
gallus) 		7 / 12 ILE A   7
ALA A   9
THR A  56
ILE A  60
LEU A  67
ARG A  70
TYR A 121
 HBI  A 198 (-4.1A)
HBI  A 198 ( 3.6A)
NAP  A 191 (-3.5A)
None
None
None
None
 0.69A 1ddrA-1dr6A:
19.5		 1ddrA-1dr6A:
33.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DDR_A_MTXA200_1
(DIHYDROFOLATE
REDUCTASE)		 1dr6 DIHYDROFOLATE
REDUCTASE
(Gallus
gallus) 		5 / 12 ILE A   7
ALA A   9
THR A  56
SER A  59
TYR A 121
 HBI  A 198 (-4.1A)
HBI  A 198 ( 3.6A)
NAP  A 191 (-3.5A)
NAP  A 191 ( 4.1A)
None
 0.79A 1ddrA-1dr6A:
19.5		 1ddrA-1dr6A:
33.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DDR_B_MTXB200_1
(DIHYDROFOLATE
REDUCTASE)		 1dr6 DIHYDROFOLATE
REDUCTASE
(Gallus
gallus) 		8 / 12 ILE A   7
ALA A   9
PHE A  34
ILE A  60
LEU A  67
ARG A  70
TYR A 121
THR A 136
 HBI  A 198 (-4.1A)
HBI  A 198 ( 3.6A)
HBI  A 198 (-4.1A)
None
None
None
None
HBI  A 198 ( 4.5A)
 0.63A 1ddrB-1dr6A:
20.1		 1ddrB-1dr6A:
33.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DDS_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 1dr6 DIHYDROFOLATE
REDUCTASE
(Gallus
gallus) 		8 / 12 ILE A   7
ALA A   9
THR A  56
ILE A  60
LEU A  67
ARG A  70
TYR A 121
THR A 136
 HBI  A 198 (-4.1A)
HBI  A 198 ( 3.6A)
NAP  A 191 (-3.5A)
None
None
None
None
HBI  A 198 ( 4.5A)
 0.63A 1ddsA-1dr6A:
20.0		 1ddsA-1dr6A:
33.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DDS_B_MTXB201_1
(DIHYDROFOLATE
REDUCTASE)		 1dr6 DIHYDROFOLATE
REDUCTASE
(Gallus
gallus) 		8 / 12 ILE A   7
ALA A   9
SER A  59
ILE A  60
LEU A  67
ARG A  70
TYR A 121
THR A 136
 HBI  A 198 (-4.1A)
HBI  A 198 ( 3.6A)
NAP  A 191 ( 4.1A)
None
None
None
None
HBI  A 198 ( 4.5A)
 0.62A 1ddsB-1dr6A:
20.4		 1ddsB-1dr6A:
33.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DF7_A_MTXA501_1
(DIHYDROFOLATE
REDUCTASE)		 1dr6 DIHYDROFOLATE
REDUCTASE
(Gallus
gallus) 		6 / 12 ILE A   7
ALA A   9
PRO A  61
LEU A  67
ARG A  70
TYR A 121
 HBI  A 198 (-4.1A)
HBI  A 198 ( 3.6A)
None
None
None
None
 0.64A 1df7A-1dr6A:
20.8		 1df7A-1dr6A:
31.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DG5_A_TOPA201_1
(DIHYDROFOLATE
REDUCTASE)		 1dr6 DIHYDROFOLATE
REDUCTASE
(Gallus
gallus) 		6 / 11 ILE A   7
ALA A   9
PHE A  34
SER A  59
PRO A  61
TYR A 121
 HBI  A 198 (-4.1A)
HBI  A 198 ( 3.6A)
HBI  A 198 (-4.1A)
NAP  A 191 ( 4.1A)
None
None
 0.68A 1dg5A-1dr6A:
20.8		 1dg5A-1dr6A:
31.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DHF_A_FOLA187_0
(DIHYDROFOLATE
REDUCTASE)		 1dr6 DIHYDROFOLATE
REDUCTASE
(Gallus
gallus) 		10 / 12 ILE A   7
ALA A   9
PHE A  34
THR A  56
ILE A  60
PRO A  61
ASN A  64
LEU A  67
TYR A 121
THR A 136
 HBI  A 198 (-4.1A)
HBI  A 198 ( 3.6A)
HBI  A 198 (-4.1A)
NAP  A 191 (-3.5A)
None
None
None
None
None
HBI  A 198 ( 4.5A)
 0.66A 1dhfA-1dr6A:
31.5		 1dhfA-1dr6A:
74.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DHF_B_FOLB187_0
(DIHYDROFOLATE
REDUCTASE)		 1dr6 DIHYDROFOLATE
REDUCTASE
(Gallus
gallus) 		8 / 12 ALA A   9
PHE A  34
THR A  56
ILE A  60
ASN A  64
LEU A  67
TYR A 121
THR A 136
 HBI  A 198 ( 3.6A)
HBI  A 198 (-4.1A)
NAP  A 191 (-3.5A)
None
None
None
None
HBI  A 198 ( 4.5A)
 0.67A 1dhfB-1dr6A:
31.9		 1dhfB-1dr6A:
74.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DHF_B_FOLB187_0
(DIHYDROFOLATE
REDUCTASE)		 1dr6 DIHYDROFOLATE
REDUCTASE
(Gallus
gallus) 		9 / 12 ILE A   7
ALA A   9
PHE A  34
THR A  56
ILE A  60
LEU A  67
ARG A  70
TYR A 121
THR A 136
 HBI  A 198 (-4.1A)
HBI  A 198 ( 3.6A)
HBI  A 198 (-4.1A)
NAP  A 191 (-3.5A)
None
None
None
None
HBI  A 198 ( 4.5A)
 0.36A 1dhfB-1dr6A:
31.9		 1dhfB-1dr6A:
74.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DHI_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 1dr6 DIHYDROFOLATE
REDUCTASE
(Gallus
gallus) 		7 / 12 ILE A   7
ALA A   9
ILE A  60
LEU A  67
ARG A  70
TYR A 121
THR A 136
 HBI  A 198 (-4.1A)
HBI  A 198 ( 3.6A)
None
None
None
None
HBI  A 198 ( 4.5A)
 0.72A 1dhiA-1dr6A:
19.9		 1dhiA-1dr6A:
33.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DHI_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 1dr6 DIHYDROFOLATE
REDUCTASE
(Gallus
gallus) 		5 / 12 ILE A   7
ALA A   9
SER A  59
TYR A 121
THR A 136
 HBI  A 198 (-4.1A)
HBI  A 198 ( 3.6A)
NAP  A 191 ( 4.1A)
None
HBI  A 198 ( 4.5A)
 0.81A 1dhiA-1dr6A:
19.9		 1dhiA-1dr6A:
33.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DHI_B_MTXB361_1
(DIHYDROFOLATE
REDUCTASE)		 1dr6 DIHYDROFOLATE
REDUCTASE
(Gallus
gallus) 		7 / 11 ILE A   7
ALA A   9
ILE A  60
LEU A  67
ARG A  70
TYR A 121
THR A 136
 HBI  A 198 (-4.1A)
HBI  A 198 ( 3.6A)
None
None
None
None
HBI  A 198 ( 4.5A)
 0.68A 1dhiB-1dr6A:
20.4		 1dhiB-1dr6A:
33.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DHJ_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 1dr6 DIHYDROFOLATE
REDUCTASE
(Gallus
gallus) 		6 / 12 ILE A   7
ALA A   9
ILE A  60
LEU A  67
ARG A  70
TYR A 121
 HBI  A 198 (-4.1A)
HBI  A 198 ( 3.6A)
None
None
None
None
 0.68A 1dhjA-1dr6A:
20.1		 1dhjA-1dr6A:
33.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DHJ_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 1dr6 DIHYDROFOLATE
REDUCTASE
(Gallus
gallus) 		6 / 12 ILE A   7
ALA A   9
LEU A  67
ARG A  70
TYR A 121
THR A 136
 HBI  A 198 (-4.1A)
HBI  A 198 ( 3.6A)
None
None
None
HBI  A 198 ( 4.5A)
 0.51A 1dhjA-1dr6A:
20.1		 1dhjA-1dr6A:
33.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DHJ_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 1dr6 DIHYDROFOLATE
REDUCTASE
(Gallus
gallus) 		5 / 12 ILE A   7
ALA A   9
SER A  59
TYR A 121
THR A 136
 HBI  A 198 (-4.1A)
HBI  A 198 ( 3.6A)
NAP  A 191 ( 4.1A)
None
HBI  A 198 ( 4.5A)
 0.83A 1dhjA-1dr6A:
20.1		 1dhjA-1dr6A:
33.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DHJ_B_MTXB361_1
(DIHYDROFOLATE
REDUCTASE)		 1dr6 DIHYDROFOLATE
REDUCTASE
(Gallus
gallus) 		6 / 12 ILE A   7
ALA A   9
LEU A  67
ARG A  70
TYR A 121
THR A 136
 HBI  A 198 (-4.1A)
HBI  A 198 ( 3.6A)
None
None
None
HBI  A 198 ( 4.5A)
 0.57A 1dhjB-1dr6A:
20.4		 1dhjB-1dr6A:
33.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DHJ_B_MTXB361_1
(DIHYDROFOLATE
REDUCTASE)		 1dr6 DIHYDROFOLATE
REDUCTASE
(Gallus
gallus) 		5 / 12 ILE A   7
ILE A  60
LEU A  67
ARG A  70
TYR A 121
 HBI  A 198 (-4.1A)
None
None
None
None
 0.63A 1dhjB-1dr6A:
20.4		 1dhjB-1dr6A:
33.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DLS_A_MTXA188_1
(DIHYDROFOLATE
REDUCTASE)		 1dr6 DIHYDROFOLATE
REDUCTASE
(Gallus
gallus) 		9 / 12 ILE A   7
ALA A   9
GLU A  30
SER A  59
ILE A  60
PRO A  61
LEU A  67
ARG A  70
TYR A 121
 HBI  A 198 (-4.1A)
HBI  A 198 ( 3.6A)
HBI  A 198 (-3.0A)
NAP  A 191 ( 4.1A)
None
None
None
None
None
 0.53A 1dlsA-1dr6A:
32.0		 1dlsA-1dr6A:
74.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DLS_A_MTXA188_1
(DIHYDROFOLATE
REDUCTASE)		 1dr6 DIHYDROFOLATE
REDUCTASE
(Gallus
gallus) 		9 / 12 ILE A   7
ALA A   9
SER A  59
ILE A  60
PRO A  61
ASN A  64
LEU A  67
ARG A  70
TYR A 121
 HBI  A 198 (-4.1A)
HBI  A 198 ( 3.6A)
NAP  A 191 ( 4.1A)
None
None
None
None
None
None
 0.67A 1dlsA-1dr6A:
32.0		 1dlsA-1dr6A:
74.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DRA_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 1dr6 DIHYDROFOLATE
REDUCTASE
(Gallus
gallus) 		7 / 12 ILE A   7
ALA A   9
GLU A  30
ILE A  60
LEU A  67
ARG A  70
TYR A 121
 HBI  A 198 (-4.1A)
HBI  A 198 ( 3.6A)
HBI  A 198 (-3.0A)
None
None
None
None
 0.72A 1draA-1dr6A:
20.1		 1draA-1dr6A:
34.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DRA_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 1dr6 DIHYDROFOLATE
REDUCTASE
(Gallus
gallus) 		5 / 12 ILE A   7
ALA A   9
GLU A  30
SER A  59
TYR A 121
 HBI  A 198 (-4.1A)
HBI  A 198 ( 3.6A)
HBI  A 198 (-3.0A)
NAP  A 191 ( 4.1A)
None
 0.80A 1draA-1dr6A:
20.1		 1draA-1dr6A:
34.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DRA_B_MTXB361_1
(DIHYDROFOLATE
REDUCTASE)		 1dr6 DIHYDROFOLATE
REDUCTASE
(Gallus
gallus) 		8 / 12 ILE A   7
ALA A   9
GLU A  30
ILE A  60
LEU A  67
ARG A  70
TYR A 121
THR A 136
 HBI  A 198 (-4.1A)
HBI  A 198 ( 3.6A)
HBI  A 198 (-3.0A)
None
None
None
None
HBI  A 198 ( 4.5A)
 0.68A 1draB-1dr6A:
20.5		 1draB-1dr6A:
34.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DRB_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 1dr6 DIHYDROFOLATE
REDUCTASE
(Gallus
gallus) 		6 / 12 ILE A   7
ALA A   9
ILE A  60
LEU A  67
ARG A  70
TYR A 121
 HBI  A 198 (-4.1A)
HBI  A 198 ( 3.6A)
None
None
None
None
 0.71A 1drbA-1dr6A:
20.0		 1drbA-1dr6A:
33.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DRB_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 1dr6 DIHYDROFOLATE
REDUCTASE
(Gallus
gallus) 		6 / 12 ILE A   7
ALA A   9
LEU A  67
ARG A  70
TYR A 121
THR A 136
 HBI  A 198 (-4.1A)
HBI  A 198 ( 3.6A)
None
None
None
HBI  A 198 ( 4.5A)
 0.53A 1drbA-1dr6A:
20.0		 1drbA-1dr6A:
33.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DRB_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 1dr6 DIHYDROFOLATE
REDUCTASE
(Gallus
gallus) 		5 / 12 ILE A   7
ALA A   9
SER A  59
TYR A 121
THR A 136
 HBI  A 198 (-4.1A)
HBI  A 198 ( 3.6A)
NAP  A 191 ( 4.1A)
None
HBI  A 198 ( 4.5A)
 0.85A 1drbA-1dr6A:
20.0		 1drbA-1dr6A:
33.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DRB_B_MTXB361_1
(DIHYDROFOLATE
REDUCTASE)		 1dr6 DIHYDROFOLATE
REDUCTASE
(Gallus
gallus) 		7 / 12 ILE A   7
ALA A   9
PHE A  34
ILE A  60
LEU A  67
ARG A  70
TYR A 121
 HBI  A 198 (-4.1A)
HBI  A 198 ( 3.6A)
HBI  A 198 (-4.1A)
None
None
None
None
 0.67A 1drbB-1dr6A:
20.5		 1drbB-1dr6A:
33.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DRB_B_MTXB361_1
(DIHYDROFOLATE
REDUCTASE)		 1dr6 DIHYDROFOLATE
REDUCTASE
(Gallus
gallus) 		7 / 12 ILE A   7
ALA A   9
PHE A  34
LEU A  67
ARG A  70
TYR A 121
THR A 136
 HBI  A 198 (-4.1A)
HBI  A 198 ( 3.6A)
HBI  A 198 (-4.1A)
None
None
None
HBI  A 198 ( 4.5A)
 0.55A 1drbB-1dr6A:
20.5		 1drbB-1dr6A:
33.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DRE_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 1dr6 DIHYDROFOLATE
REDUCTASE
(Gallus
gallus) 		7 / 12 ALA A   9
PHE A  34
SER A  59
ILE A  60
LEU A  67
ARG A  70
TYR A 121
 HBI  A 198 ( 3.6A)
HBI  A 198 (-4.1A)
NAP  A 191 ( 4.1A)
None
None
None
None
 0.70A 1dreA-1dr6A:
20.6		 1dreA-1dr6A:
33.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DRF_A_FOLA187_0
(DIHYDROFOLATE
REDUCTASE)		 1dr6 DIHYDROFOLATE
REDUCTASE
(Gallus
gallus) 		6 / 12 ALA A   9
LEU A  22
ARG A  28
SER A  59
ILE A  60
PRO A  61
 HBI  A 198 ( 3.6A)
NAP  A 191 ( 4.7A)
None
NAP  A 191 ( 4.1A)
None
None
 1.18A 1drfA-1dr6A:
31.0		 1drfA-1dr6A:
74.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DRF_A_FOLA187_0
(DIHYDROFOLATE
REDUCTASE)		 1dr6 DIHYDROFOLATE
REDUCTASE
(Gallus
gallus) 		9 / 12 ILE A   7
ALA A   9
LEU A  22
PHE A  34
SER A  59
ILE A  60
PRO A  61
LEU A  67
TYR A 121
 HBI  A 198 (-4.1A)
HBI  A 198 ( 3.6A)
NAP  A 191 ( 4.7A)
HBI  A 198 (-4.1A)
NAP  A 191 ( 4.1A)
None
None
None
None
 0.67A 1drfA-1dr6A:
31.0		 1drfA-1dr6A:
74.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DYI_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 1dr6 DIHYDROFOLATE
REDUCTASE
(Gallus
gallus) 		8 / 12 ILE A   7
ALA A   9
PHE A  34
THR A  56
ILE A  60
LEU A  67
TYR A 121
THR A 136
 HBI  A 198 (-4.1A)
HBI  A 198 ( 3.6A)
HBI  A 198 (-4.1A)
NAP  A 191 (-3.5A)
None
None
None
HBI  A 198 ( 4.5A)
 0.60A 1dyiA-1dr6A:
20.1		 1dyiA-1dr6A:
33.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DYI_B_FOLB161_0
(DIHYDROFOLATE
REDUCTASE)		 1dr6 DIHYDROFOLATE
REDUCTASE
(Gallus
gallus) 		8 / 12 ILE A   7
ALA A   9
PHE A  34
THR A  56
ILE A  60
LEU A  67
TYR A 121
THR A 136
 HBI  A 198 (-4.1A)
HBI  A 198 ( 3.6A)
HBI  A 198 (-4.1A)
NAP  A 191 (-3.5A)
None
None
None
HBI  A 198 ( 4.5A)
 0.55A 1dyiB-1dr6A:
20.4		 1dyiB-1dr6A:
33.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DYR_A_TOPA407_1
(DIHYDROFOLATE
REDUCTASE)		 1dr6 DIHYDROFOLATE
REDUCTASE
(Gallus
gallus) 		8 / 11 ILE A   7
ALA A   9
LEU A  22
GLU A  30
PHE A  34
ILE A  60
TYR A 121
THR A 136
 HBI  A 198 (-4.1A)
HBI  A 198 ( 3.6A)
NAP  A 191 ( 4.7A)
HBI  A 198 (-3.0A)
HBI  A 198 (-4.1A)
None
None
HBI  A 198 ( 4.5A)
 0.60A 1dyrA-1dr6A:
24.9		 1dyrA-1dr6A:
39.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DYR_A_TOPA407_1
(DIHYDROFOLATE
REDUCTASE)		 1dr6 DIHYDROFOLATE
REDUCTASE
(Gallus
gallus) 		8 / 11 ILE A   7
ALA A   9
LEU A  22
PHE A  34
ILE A  60
PRO A  61
TYR A 121
THR A 136
 HBI  A 198 (-4.1A)
HBI  A 198 ( 3.6A)
NAP  A 191 ( 4.7A)
HBI  A 198 (-4.1A)
None
None
None
HBI  A 198 ( 4.5A)
 0.70A 1dyrA-1dr6A:
24.9		 1dyrA-1dr6A:
39.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J37_A_X8ZA801_1
(ANGIOTENSIN
CONVERTING ENZYME)		 2toh TYROSINE
3-MONOOXYGENASE
(Rattus
norvegicus) 		5 / 11 GLU A 332
HIS A 331
GLU A 376
LYS A 301
TYR A 371
 HBI  A 500 (-3.2A)
FE  A 501 ( 3.3A)
FE  A 501 (-2.1A)
MTY  A 300 ( 2.9A)
MTY  A 300 (-3.9A)
 1.25A 1j37A-2tohA:
undetectable		 1j37A-2tohA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J37_B_X8ZB802_1
(ANGIOTENSIN
CONVERTING ENZYME)		 2toh TYROSINE
3-MONOOXYGENASE
(Rattus
norvegicus) 		5 / 11 GLU A 332
HIS A 331
GLU A 376
LYS A 301
TYR A 371
 HBI  A 500 (-3.2A)
FE  A 501 ( 3.3A)
FE  A 501 (-2.1A)
MTY  A 300 ( 2.9A)
MTY  A 300 (-3.9A)
 1.25A 1j37B-2tohA:
undetectable		 1j37B-2tohA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J3J_A_CP6A609_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1dr6 DIHYDROFOLATE
REDUCTASE
(Gallus
gallus) 		7 / 10 ILE A   7
ALA A   9
PHE A  34
SER A  59
ILE A  60
TYR A 121
THR A 136
 HBI  A 198 (-4.1A)
HBI  A 198 ( 3.6A)
HBI  A 198 (-4.1A)
NAP  A 191 ( 4.1A)
None
None
HBI  A 198 ( 4.5A)
 0.39A 1j3jA-1dr6A:
22.7		 1j3jA-1dr6A:
26.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J3J_B_CP6B709_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1dr6 DIHYDROFOLATE
REDUCTASE
(Gallus
gallus) 		6 / 9 ALA A   9
PHE A  34
SER A  59
ILE A  60
TYR A 121
THR A 136
 HBI  A 198 ( 3.6A)
HBI  A 198 (-4.1A)
NAP  A 191 ( 4.1A)
None
None
HBI  A 198 ( 4.5A)
 0.31A 1j3jB-1dr6A:
22.6		 1j3jB-1dr6A:
26.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1J8U_A_H4BA429_1
(PHENYLALANINE-4-HYDR
OXYLASE)		 1dmw PHENYLALANINE
HYDROXYLASE
(Homo
sapiens) 		5 / 7 VAL A 245
LEU A 248
LEU A 249
PHE A 254
LEU A 255
 None
HBI  A 700 ( 4.5A)
HBI  A 700 (-4.6A)
HBI  A 700 (-3.6A)
HBI  A 700 (-4.7A)
 0.68A 1j8uA-1dmwA:
55.0		 1j8uA-1dmwA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1J8U_A_H4BA429_1
(PHENYLALANINE-4-HYDR
OXYLASE)		 1dmw PHENYLALANINE
HYDROXYLASE
(Homo
sapiens) 		6 / 7 VAL A 245
LEU A 249
SER A 251
PHE A 254
LEU A 255
ALA A 322
 None
HBI  A 700 (-4.6A)
HBI  A 700 (-3.6A)
HBI  A 700 (-3.6A)
HBI  A 700 (-4.7A)
HBI  A 700 (-3.6A)
 0.13A 1j8uA-1dmwA:
55.0		 1j8uA-1dmwA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J8U_A_H4BA429_1
(PHENYLALANINE-4-HYDR
OXYLASE)		 1ltz PHENYLALANINE-4-HYDR
OXYLASE
(Chromobacterium
violaceum) 		4 / 7 VAL A  98
LEU A 101
PHE A 107
ALA A 176
 None
HBI  A 500 ( 4.5A)
HBI  A 500 (-3.8A)
HBI  A 500 ( 4.2A)
 0.84A 1j8uA-1ltzA:
28.1		 1j8uA-1ltzA:
27.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1J8U_A_H4BA429_1
(PHENYLALANINE-4-HYDR
OXYLASE)		 2toh TYROSINE
3-MONOOXYGENASE
(Rattus
norvegicus) 		4 / 7 VAL A 291
LEU A 294
LEU A 295
LEU A 301
 HBI  A 500 ( 4.6A)
HBI  A 500 (-4.7A)
HBI  A 500 (-4.2A)
MTY  A 300 ( 4.2A)
 0.53A 1j8uA-2tohA:
48.7		 1j8uA-2tohA:
59.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JOL_A_FFOA161_0
(DIHYDROFOLATE
REDUCTASE)		 1dr6 DIHYDROFOLATE
REDUCTASE
(Gallus
gallus) 		7 / 12 ILE A   7
ALA A   9
PHE A  34
ILE A  60
LEU A  67
TYR A 121
THR A 136
 HBI  A 198 (-4.1A)
HBI  A 198 ( 3.6A)
HBI  A 198 (-4.1A)
None
None
None
HBI  A 198 ( 4.5A)
 0.76A 1jolA-1dr6A:
20.1		 1jolA-1dr6A:
33.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JOL_B_FFOB361_0
(DIHYDROFOLATE
REDUCTASE)		 1dr6 DIHYDROFOLATE
REDUCTASE
(Gallus
gallus) 		6 / 12 ILE A   7
ALA A   9
PHE A  34
ILE A  60
LEU A  67
TYR A 121
 HBI  A 198 (-4.1A)
HBI  A 198 ( 3.6A)
HBI  A 198 (-4.1A)
None
None
None
 0.74A 1jolB-1dr6A:
20.4		 1jolB-1dr6A:
33.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JOL_B_FFOB361_0
(DIHYDROFOLATE
REDUCTASE)		 1dr6 DIHYDROFOLATE
REDUCTASE
(Gallus
gallus) 		6 / 12 ILE A   7
ALA A   9
PHE A  34
LEU A  67
TYR A 121
THR A 136
 HBI  A 198 (-4.1A)
HBI  A 198 ( 3.6A)
HBI  A 198 (-4.1A)
None
None
HBI  A 198 ( 4.5A)
 0.53A 1jolB-1dr6A:
20.4		 1jolB-1dr6A:
33.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JOM_A_FFOA161_0
(DIHYDROFOLATE
REDUCTASE)		 1dr6 DIHYDROFOLATE
REDUCTASE
(Gallus
gallus) 		7 / 11 ALA A   9
PHE A  34
ILE A  60
LEU A  67
ARG A  70
TYR A 121
THR A 136
 HBI  A 198 ( 3.6A)
HBI  A 198 (-4.1A)
None
None
None
None
HBI  A 198 ( 4.5A)
 0.69A 1jomA-1dr6A:
19.7		 1jomA-1dr6A:
33.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1KW0_A_H4BA429_1
(PHENYLALANINE-4-HYDR
OXYLASE)		 1dmw PHENYLALANINE
HYDROXYLASE
(Homo
sapiens) 		9 / 12 VAL A 245
LEU A 248
LEU A 249
PHE A 254
LEU A 255
THR A 266
HIS A 290
TYR A 325
GLU A 330
 None
HBI  A 700 ( 4.5A)
HBI  A 700 (-4.6A)
HBI  A 700 (-3.6A)
HBI  A 700 (-4.7A)
None
FE  A 425 (-3.3A)
HBI  A 700 (-3.8A)
FE  A 425 (-2.5A)
 1.05A 1kw0A-1dmwA:
42.7		 1kw0A-1dmwA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1KW0_A_H4BA429_1
(PHENYLALANINE-4-HYDR
OXYLASE)		 1dmw PHENYLALANINE
HYDROXYLASE
(Homo
sapiens) 		9 / 12 VAL A 245
LEU A 248
LEU A 249
SER A 251
PHE A 254
LEU A 255
THR A 266
HIS A 290
TYR A 325
 None
HBI  A 700 ( 4.5A)
HBI  A 700 (-4.6A)
HBI  A 700 (-3.6A)
HBI  A 700 (-3.6A)
HBI  A 700 (-4.7A)
None
FE  A 425 (-3.3A)
HBI  A 700 (-3.8A)
 0.98A 1kw0A-1dmwA:
42.7		 1kw0A-1dmwA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1KW0_A_H4BA429_1
(PHENYLALANINE-4-HYDR
OXYLASE)		 1dmw PHENYLALANINE
HYDROXYLASE
(Homo
sapiens) 		9 / 12 VAL A 245
PHE A 254
LEU A 255
THR A 266
GLU A 286
HIS A 290
TYR A 325
TRP A 326
GLU A 330
 None
HBI  A 700 (-3.6A)
HBI  A 700 (-4.7A)
None
None
FE  A 425 (-3.3A)
HBI  A 700 (-3.8A)
None
FE  A 425 (-2.5A)
 0.99A 1kw0A-1dmwA:
42.7		 1kw0A-1dmwA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1KW0_A_H4BA429_1
(PHENYLALANINE-4-HYDR
OXYLASE)		 1dmw PHENYLALANINE
HYDROXYLASE
(Homo
sapiens) 		8 / 12 VAL A 245
SER A 251
PHE A 254
LEU A 255
THR A 266
GLU A 286
HIS A 290
TYR A 325
 None
HBI  A 700 (-3.6A)
HBI  A 700 (-3.6A)
HBI  A 700 (-4.7A)
None
None
FE  A 425 (-3.3A)
HBI  A 700 (-3.8A)
 0.92A 1kw0A-1dmwA:
42.7		 1kw0A-1dmwA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KW0_A_H4BA429_1
(PHENYLALANINE-4-HYDR
OXYLASE)		 1ltz PHENYLALANINE-4-HYDR
OXYLASE
(Chromobacterium
violaceum) 		5 / 12 VAL A  98
HIS A 143
TYR A 179
TRP A 180
GLU A 184
 None
FE  A 400 (-3.4A)
HBI  A 500 ( 4.0A)
None
FE  A 400 (-1.9A)
 0.96A 1kw0A-1ltzA:
26.7		 1kw0A-1ltzA:
27.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KW0_A_H4BA429_1
(PHENYLALANINE-4-HYDR
OXYLASE)		 1ltz PHENYLALANINE-4-HYDR
OXYLASE
(Chromobacterium
violaceum) 		5 / 12 VAL A  98
LEU A 101
HIS A 143
TYR A 179
GLU A 184
 None
HBI  A 500 ( 4.5A)
FE  A 400 (-3.4A)
HBI  A 500 ( 4.0A)
FE  A 400 (-1.9A)
 0.71A 1kw0A-1ltzA:
26.7		 1kw0A-1ltzA:
27.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KW0_A_H4BA429_1
(PHENYLALANINE-4-HYDR
OXYLASE)		 1ltz PHENYLALANINE-4-HYDR
OXYLASE
(Chromobacterium
violaceum) 		5 / 12 VAL A  98
LEU A 101
PHE A 107
THR A 119
GLU A 184
 None
HBI  A 500 ( 4.5A)
HBI  A 500 (-3.8A)
None
FE  A 400 (-1.9A)
 1.09A 1kw0A-1ltzA:
26.7		 1kw0A-1ltzA:
27.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KW0_A_H4BA429_1
(PHENYLALANINE-4-HYDR
OXYLASE)		 1ltz PHENYLALANINE-4-HYDR
OXYLASE
(Chromobacterium
violaceum) 		5 / 12 VAL A  98
LEU A 101
PHE A 107
TYR A 179
GLU A 184
 None
HBI  A 500 ( 4.5A)
HBI  A 500 (-3.8A)
HBI  A 500 ( 4.0A)
FE  A 400 (-1.9A)
 1.10A 1kw0A-1ltzA:
26.7		 1kw0A-1ltzA:
27.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KW0_A_H4BA429_1
(PHENYLALANINE-4-HYDR
OXYLASE)		 1ltz PHENYLALANINE-4-HYDR
OXYLASE
(Chromobacterium
violaceum) 		5 / 12 VAL A  98
LEU A 101
THR A 119
HIS A 143
GLU A 184
 None
HBI  A 500 ( 4.5A)
None
FE  A 400 (-3.4A)
FE  A 400 (-1.9A)
 0.61A 1kw0A-1ltzA:
26.7		 1kw0A-1ltzA:
27.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KW0_A_H4BA429_1
(PHENYLALANINE-4-HYDR
OXYLASE)		 1ltz PHENYLALANINE-4-HYDR
OXYLASE
(Chromobacterium
violaceum) 		5 / 12 VAL A  98
PHE A 107
THR A 119
TRP A 180
GLU A 184
 None
HBI  A 500 (-3.8A)
None
None
FE  A 400 (-1.9A)
 1.16A 1kw0A-1ltzA:
26.7		 1kw0A-1ltzA:
27.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KW0_A_H4BA429_1
(PHENYLALANINE-4-HYDR
OXYLASE)		 1ltz PHENYLALANINE-4-HYDR
OXYLASE
(Chromobacterium
violaceum) 		5 / 12 VAL A  98
PHE A 107
TYR A 179
TRP A 180
GLU A 184
 None
HBI  A 500 (-3.8A)
HBI  A 500 ( 4.0A)
None
FE  A 400 (-1.9A)
 1.24A 1kw0A-1ltzA:
26.7		 1kw0A-1ltzA:
27.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1KW0_A_H4BA429_1
(PHENYLALANINE-4-HYDR
OXYLASE)		 2toh TYROSINE
3-MONOOXYGENASE
(Rattus
norvegicus) 		9 / 12 LEU A 294
LEU A 295
LEU A 301
THR A 312
GLU A 332
HIS A 336
TYR A 371
TRP A 372
GLU A 376
 HBI  A 500 (-4.7A)
HBI  A 500 (-4.2A)
MTY  A 300 ( 4.2A)
HBI  A 500 ( 4.4A)
HBI  A 500 (-3.2A)
FE  A 501 ( 3.4A)
MTY  A 300 (-3.9A)
None
FE  A 501 (-2.1A)
 0.97A 1kw0A-2tohA:
42.9		 1kw0A-2tohA:
59.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1KW0_A_H4BA429_1
(PHENYLALANINE-4-HYDR
OXYLASE)		 2toh TYROSINE
3-MONOOXYGENASE
(Rattus
norvegicus) 		9 / 12 VAL A 291
LEU A 294
LEU A 295
LEU A 301
THR A 312
GLU A 332
HIS A 336
TRP A 372
GLU A 376
 HBI  A 500 ( 4.6A)
HBI  A 500 (-4.7A)
HBI  A 500 (-4.2A)
MTY  A 300 ( 4.2A)
HBI  A 500 ( 4.4A)
HBI  A 500 (-3.2A)
FE  A 501 ( 3.4A)
None
FE  A 501 (-2.1A)
 0.91A 1kw0A-2tohA:
42.9		 1kw0A-2tohA:
59.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1MMK_A_H4BA1427_1
(PHENYLALANINE-4-HYDR
OXYLASE)		 1dmw PHENYLALANINE
HYDROXYLASE
(Homo
sapiens) 		8 / 12 VAL A 245
LEU A 248
LEU A 249
PHE A 254
LEU A 255
HIS A 290
TYR A 325
GLU A 330
 None
HBI  A 700 ( 4.5A)
HBI  A 700 (-4.6A)
HBI  A 700 (-3.6A)
HBI  A 700 (-4.7A)
FE  A 425 (-3.3A)
HBI  A 700 (-3.8A)
FE  A 425 (-2.5A)
 1.01A 1mmkA-1dmwA:
42.9		 1mmkA-1dmwA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1MMK_A_H4BA1427_1
(PHENYLALANINE-4-HYDR
OXYLASE)		 1dmw PHENYLALANINE
HYDROXYLASE
(Homo
sapiens) 		8 / 12 VAL A 245
LEU A 248
LEU A 249
SER A 251
PHE A 254
LEU A 255
HIS A 290
TYR A 325
 None
HBI  A 700 ( 4.5A)
HBI  A 700 (-4.6A)
HBI  A 700 (-3.6A)
HBI  A 700 (-3.6A)
HBI  A 700 (-4.7A)
FE  A 425 (-3.3A)
HBI  A 700 (-3.8A)
 0.94A 1mmkA-1dmwA:
42.9		 1mmkA-1dmwA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1MMK_A_H4BA1427_1
(PHENYLALANINE-4-HYDR
OXYLASE)		 1dmw PHENYLALANINE
HYDROXYLASE
(Homo
sapiens) 		8 / 12 VAL A 245
LEU A 249
PHE A 254
LEU A 255
GLU A 286
HIS A 290
TYR A 325
GLU A 330
 None
HBI  A 700 (-4.6A)
HBI  A 700 (-3.6A)
HBI  A 700 (-4.7A)
None
FE  A 425 (-3.3A)
HBI  A 700 (-3.8A)
FE  A 425 (-2.5A)
 0.90A 1mmkA-1dmwA:
42.9		 1mmkA-1dmwA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1MMK_A_H4BA1427_1
(PHENYLALANINE-4-HYDR
OXYLASE)		 1dmw PHENYLALANINE
HYDROXYLASE
(Homo
sapiens) 		8 / 12 VAL A 245
LEU A 249
SER A 251
PHE A 254
LEU A 255
GLU A 286
HIS A 290
TYR A 325
 None
HBI  A 700 (-4.6A)
HBI  A 700 (-3.6A)
HBI  A 700 (-3.6A)
HBI  A 700 (-4.7A)
None
FE  A 425 (-3.3A)
HBI  A 700 (-3.8A)
 0.88A 1mmkA-1dmwA:
42.9		 1mmkA-1dmwA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1MMK_A_H4BA1427_1
(PHENYLALANINE-4-HYDR
OXYLASE)		 1dmw PHENYLALANINE
HYDROXYLASE
(Homo
sapiens) 		8 / 12 VAL A 245
PHE A 254
LEU A 255
GLU A 286
HIS A 290
TYR A 325
TRP A 326
GLU A 330
 None
HBI  A 700 (-3.6A)
HBI  A 700 (-4.7A)
None
FE  A 425 (-3.3A)
HBI  A 700 (-3.8A)
None
FE  A 425 (-2.5A)
 0.95A 1mmkA-1dmwA:
42.9		 1mmkA-1dmwA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MMK_A_H4BA1427_1
(PHENYLALANINE-4-HYDR
OXYLASE)		 1ltz PHENYLALANINE-4-HYDR
OXYLASE
(Chromobacterium
violaceum) 		5 / 12 LEU A 101
LEU A 111
HIS A 143
TYR A 179
GLU A 184
 HBI  A 500 ( 4.5A)
None
FE  A 400 (-3.4A)
HBI  A 500 ( 4.0A)
FE  A 400 (-1.9A)
 1.47A 1mmkA-1ltzA:
26.6		 1mmkA-1ltzA:
27.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MMK_A_H4BA1427_1
(PHENYLALANINE-4-HYDR
OXYLASE)		 1ltz PHENYLALANINE-4-HYDR
OXYLASE
(Chromobacterium
violaceum) 		5 / 12 VAL A  98
HIS A 143
TYR A 179
TRP A 180
GLU A 184
 None
FE  A 400 (-3.4A)
HBI  A 500 ( 4.0A)
None
FE  A 400 (-1.9A)
 0.94A 1mmkA-1ltzA:
26.6		 1mmkA-1ltzA:
27.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MMK_A_H4BA1427_1
(PHENYLALANINE-4-HYDR
OXYLASE)		 1ltz PHENYLALANINE-4-HYDR
OXYLASE
(Chromobacterium
violaceum) 		5 / 12 VAL A  98
LEU A 101
HIS A 143
TYR A 179
GLU A 184
 None
HBI  A 500 ( 4.5A)
FE  A 400 (-3.4A)
HBI  A 500 ( 4.0A)
FE  A 400 (-1.9A)
 0.70A 1mmkA-1ltzA:
26.6		 1mmkA-1ltzA:
27.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MMK_A_H4BA1427_1
(PHENYLALANINE-4-HYDR
OXYLASE)		 1ltz PHENYLALANINE-4-HYDR
OXYLASE
(Chromobacterium
violaceum) 		5 / 12 VAL A  98
LEU A 101
PHE A 107
TYR A 179
GLU A 184
 None
HBI  A 500 ( 4.5A)
HBI  A 500 (-3.8A)
HBI  A 500 ( 4.0A)
FE  A 400 (-1.9A)
 1.05A 1mmkA-1ltzA:
26.6		 1mmkA-1ltzA:
27.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MMK_A_H4BA1427_1
(PHENYLALANINE-4-HYDR
OXYLASE)		 1ltz PHENYLALANINE-4-HYDR
OXYLASE
(Chromobacterium
violaceum) 		5 / 12 VAL A  98
PHE A 107
TYR A 179
TRP A 180
GLU A 184
 None
HBI  A 500 (-3.8A)
HBI  A 500 ( 4.0A)
None
FE  A 400 (-1.9A)
 1.21A 1mmkA-1ltzA:
26.6		 1mmkA-1ltzA:
27.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1MMK_A_H4BA1427_1
(PHENYLALANINE-4-HYDR
OXYLASE)		 2toh TYROSINE
3-MONOOXYGENASE
(Rattus
norvegicus) 		8 / 12 LEU A 294
LEU A 295
LEU A 301
GLU A 332
HIS A 336
TYR A 371
TRP A 372
GLU A 376
 HBI  A 500 (-4.7A)
HBI  A 500 (-4.2A)
MTY  A 300 ( 4.2A)
HBI  A 500 (-3.2A)
FE  A 501 ( 3.4A)
MTY  A 300 (-3.9A)
None
FE  A 501 (-2.1A)
 1.00A 1mmkA-2tohA:
43.0		 1mmkA-2tohA:
59.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1MMK_A_H4BA1427_1
(PHENYLALANINE-4-HYDR
OXYLASE)		 2toh TYROSINE
3-MONOOXYGENASE
(Rattus
norvegicus) 		8 / 12 VAL A 291
LEU A 294
LEU A 295
LEU A 301
GLU A 332
HIS A 336
TRP A 372
GLU A 376
 HBI  A 500 ( 4.6A)
HBI  A 500 (-4.7A)
HBI  A 500 (-4.2A)
MTY  A 300 ( 4.2A)
HBI  A 500 (-3.2A)
FE  A 501 ( 3.4A)
None
FE  A 501 (-2.1A)
 0.94A 1mmkA-2tohA:
43.0		 1mmkA-2tohA:
59.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1MMT_A_H4BA1426_1
(PHENYLALANINE-4-HYDR
OXYLASE)		 1dmw PHENYLALANINE
HYDROXYLASE
(Homo
sapiens) 		8 / 11 LEU A 248
LEU A 249
PHE A 254
LEU A 255
THR A 266
HIS A 290
TYR A 325
GLU A 330
 HBI  A 700 ( 4.5A)
HBI  A 700 (-4.6A)
HBI  A 700 (-3.6A)
HBI  A 700 (-4.7A)
None
FE  A 425 (-3.3A)
HBI  A 700 (-3.8A)
FE  A 425 (-2.5A)
 0.98A 1mmtA-1dmwA:
42.8		 1mmtA-1dmwA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1MMT_A_H4BA1426_1
(PHENYLALANINE-4-HYDR
OXYLASE)		 1dmw PHENYLALANINE
HYDROXYLASE
(Homo
sapiens) 		8 / 11 LEU A 248
LEU A 249
SER A 251
PHE A 254
LEU A 255
THR A 266
HIS A 290
TYR A 325
 HBI  A 700 ( 4.5A)
HBI  A 700 (-4.6A)
HBI  A 700 (-3.6A)
HBI  A 700 (-3.6A)
HBI  A 700 (-4.7A)
None
FE  A 425 (-3.3A)
HBI  A 700 (-3.8A)
 0.92A 1mmtA-1dmwA:
42.8		 1mmtA-1dmwA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1MMT_A_H4BA1426_1
(PHENYLALANINE-4-HYDR
OXYLASE)		 1dmw PHENYLALANINE
HYDROXYLASE
(Homo
sapiens) 		8 / 11 LEU A 249
PHE A 254
LEU A 255
THR A 266
GLU A 286
HIS A 290
TYR A 325
GLU A 330
 HBI  A 700 (-4.6A)
HBI  A 700 (-3.6A)
HBI  A 700 (-4.7A)
None
None
FE  A 425 (-3.3A)
HBI  A 700 (-3.8A)
FE  A 425 (-2.5A)
 0.87A 1mmtA-1dmwA:
42.8		 1mmtA-1dmwA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1MMT_A_H4BA1426_1
(PHENYLALANINE-4-HYDR
OXYLASE)		 1dmw PHENYLALANINE
HYDROXYLASE
(Homo
sapiens) 		8 / 11 LEU A 249
SER A 251
PHE A 254
LEU A 255
THR A 266
GLU A 286
HIS A 290
TYR A 325
 HBI  A 700 (-4.6A)
HBI  A 700 (-3.6A)
HBI  A 700 (-3.6A)
HBI  A 700 (-4.7A)
None
None
FE  A 425 (-3.3A)
HBI  A 700 (-3.8A)
 0.87A 1mmtA-1dmwA:
42.8		 1mmtA-1dmwA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1MMT_A_H4BA1426_1
(PHENYLALANINE-4-HYDR
OXYLASE)		 1dmw PHENYLALANINE
HYDROXYLASE
(Homo
sapiens) 		8 / 11 VAL A 245
LEU A 248
LEU A 249
PHE A 254
LEU A 255
THR A 266
HIS A 290
GLU A 330
 None
HBI  A 700 ( 4.5A)
HBI  A 700 (-4.6A)
HBI  A 700 (-3.6A)
HBI  A 700 (-4.7A)
None
FE  A 425 (-3.3A)
FE  A 425 (-2.5A)
 0.99A 1mmtA-1dmwA:
42.8		 1mmtA-1dmwA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1MMT_A_H4BA1426_1
(PHENYLALANINE-4-HYDR
OXYLASE)		 1dmw PHENYLALANINE
HYDROXYLASE
(Homo
sapiens) 		8 / 11 VAL A 245
LEU A 248
LEU A 249
SER A 251
PHE A 254
LEU A 255
THR A 266
HIS A 290
 None
HBI  A 700 ( 4.5A)
HBI  A 700 (-4.6A)
HBI  A 700 (-3.6A)
HBI  A 700 (-3.6A)
HBI  A 700 (-4.7A)
None
FE  A 425 (-3.3A)
 0.92A 1mmtA-1dmwA:
42.8		 1mmtA-1dmwA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1MMT_A_H4BA1426_1
(PHENYLALANINE-4-HYDR
OXYLASE)		 1dmw PHENYLALANINE
HYDROXYLASE
(Homo
sapiens) 		8 / 11 VAL A 245
LEU A 249
PHE A 254
LEU A 255
THR A 266
GLU A 286
HIS A 290
GLU A 330
 None
HBI  A 700 (-4.6A)
HBI  A 700 (-3.6A)
HBI  A 700 (-4.7A)
None
None
FE  A 425 (-3.3A)
FE  A 425 (-2.5A)
 0.83A 1mmtA-1dmwA:
42.8		 1mmtA-1dmwA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1MMT_A_H4BA1426_1
(PHENYLALANINE-4-HYDR
OXYLASE)		 1dmw PHENYLALANINE
HYDROXYLASE
(Homo
sapiens) 		8 / 11 VAL A 245
LEU A 249
SER A 251
PHE A 254
LEU A 255
THR A 266
GLU A 286
HIS A 290
 None
HBI  A 700 (-4.6A)
HBI  A 700 (-3.6A)
HBI  A 700 (-3.6A)
HBI  A 700 (-4.7A)
None
None
FE  A 425 (-3.3A)
 0.83A 1mmtA-1dmwA:
42.8		 1mmtA-1dmwA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MMT_A_H4BA1426_1
(PHENYLALANINE-4-HYDR
OXYLASE)		 1ltz PHENYLALANINE-4-HYDR
OXYLASE
(Chromobacterium
violaceum) 		6 / 11 VAL A  98
LEU A 101
PHE A 107
THR A 119
TYR A 179
GLU A 184
 None
HBI  A 500 ( 4.5A)
HBI  A 500 (-3.8A)
None
HBI  A 500 ( 4.0A)
FE  A 400 (-1.9A)
 1.05A 1mmtA-1ltzA:
26.7		 1mmtA-1ltzA:
27.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MMT_A_H4BA1426_1
(PHENYLALANINE-4-HYDR
OXYLASE)		 1ltz PHENYLALANINE-4-HYDR
OXYLASE
(Chromobacterium
violaceum) 		6 / 11 VAL A  98
LEU A 101
THR A 119
HIS A 143
TYR A 179
GLU A 184
 None
HBI  A 500 ( 4.5A)
None
FE  A 400 (-3.4A)
HBI  A 500 ( 4.0A)
FE  A 400 (-1.9A)
 0.72A 1mmtA-1ltzA:
26.7		 1mmtA-1ltzA:
27.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1MMT_A_H4BA1426_1
(PHENYLALANINE-4-HYDR
OXYLASE)		 2toh TYROSINE
3-MONOOXYGENASE
(Rattus
norvegicus) 		8 / 11 LEU A 294
LEU A 295
LEU A 301
THR A 312
GLU A 332
HIS A 336
TYR A 371
GLU A 376
 HBI  A 500 (-4.7A)
HBI  A 500 (-4.2A)
MTY  A 300 ( 4.2A)
HBI  A 500 ( 4.4A)
HBI  A 500 (-3.2A)
FE  A 501 ( 3.4A)
MTY  A 300 (-3.9A)
FE  A 501 (-2.1A)
 0.86A 1mmtA-2tohA:
43.0		 1mmtA-2tohA:
59.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1MMT_A_H4BA1426_1
(PHENYLALANINE-4-HYDR
OXYLASE)		 2toh TYROSINE
3-MONOOXYGENASE
(Rattus
norvegicus) 		8 / 11 VAL A 291
LEU A 294
LEU A 295
LEU A 301
THR A 312
GLU A 332
HIS A 336
GLU A 376
 HBI  A 500 ( 4.6A)
HBI  A 500 (-4.7A)
HBI  A 500 (-4.2A)
MTY  A 300 ( 4.2A)
HBI  A 500 ( 4.4A)
HBI  A 500 (-3.2A)
FE  A 501 ( 3.4A)
FE  A 501 (-2.1A)
 0.84A 1mmtA-2tohA:
43.0		 1mmtA-2tohA:
59.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P7L_C_SAMC685_0
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 1ltz PHENYLALANINE-4-HYDR
OXYLASE
(Chromobacterium
violaceum) 		4 / 8 HIS A 138
PRO A 134
ASP A 139
PHE A 116
 FE  A 400 (-3.3A)
None
HBI  A 500 ( 4.9A)
None
 1.05A 1p7lC-1ltzA:
undetectable		 1p7lC-1ltzA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P7L_C_SAMC885_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 1ltz PHENYLALANINE-4-HYDR
OXYLASE
(Chromobacterium
violaceum) 		4 / 8 HIS A 138
PRO A 134
ASP A 139
PHE A 116
 FE  A 400 (-3.3A)
None
HBI  A 500 ( 4.9A)
None
 1.06A 1p7lD-1ltzA:
undetectable		 1p7lD-1ltzA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZF_A_FOLA605_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1dr6 DIHYDROFOLATE
REDUCTASE
(Gallus
gallus) 		8 / 12 ALA A   9
LEU A  22
THR A  56
ILE A  60
LEU A  67
ARG A  70
TYR A 121
THR A 136
 HBI  A 198 ( 3.6A)
NAP  A 191 ( 4.7A)
NAP  A 191 (-3.5A)
None
None
None
None
HBI  A 198 ( 4.5A)
 0.59A 1qzfA-1dr6A:
22.1		 1qzfA-1dr6A:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZF_B_FOLB609_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1dr6 DIHYDROFOLATE
REDUCTASE
(Gallus
gallus) 		8 / 12 ALA A   9
LEU A  22
THR A  56
ILE A  60
LEU A  67
ARG A  70
TYR A 121
THR A 136
 HBI  A 198 ( 3.6A)
NAP  A 191 ( 4.7A)
NAP  A 191 (-3.5A)
None
None
None
None
HBI  A 198 ( 4.5A)
 0.60A 1qzfB-1dr6A:
22.0		 1qzfB-1dr6A:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZF_C_FOLC613_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1dr6 DIHYDROFOLATE
REDUCTASE
(Gallus
gallus) 		8 / 12 ALA A   9
LEU A  22
THR A  56
ILE A  60
LEU A  67
ARG A  70
TYR A 121
THR A 136
 HBI  A 198 ( 3.6A)
NAP  A 191 ( 4.7A)
NAP  A 191 (-3.5A)
None
None
None
None
HBI  A 198 ( 4.5A)
 0.60A 1qzfC-1dr6A:
22.0		 1qzfC-1dr6A:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZF_D_FOLD617_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1dr6 DIHYDROFOLATE
REDUCTASE
(Gallus
gallus) 		8 / 12 ALA A   9
LEU A  22
THR A  56
ILE A  60
LEU A  67
ARG A  70
TYR A 121
THR A 136
 HBI  A 198 ( 3.6A)
NAP  A 191 ( 4.7A)
NAP  A 191 (-3.5A)
None
None
None
None
HBI  A 198 ( 4.5A)
 0.61A 1qzfD-1dr6A:
22.0		 1qzfD-1dr6A:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZF_E_FOLE621_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1dr6 DIHYDROFOLATE
REDUCTASE
(Gallus
gallus) 		8 / 12 ALA A   9
LEU A  22
THR A  56
ILE A  60
LEU A  67
ARG A  70
TYR A 121
THR A 136
 HBI  A 198 ( 3.6A)
NAP  A 191 ( 4.7A)
NAP  A 191 (-3.5A)
None
None
None
None
HBI  A 198 ( 4.5A)
 0.62A 1qzfE-1dr6A:
22.1		 1qzfE-1dr6A:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R9O_A_FLPA501_1
(CYTOCHROME P450 2C9)		 1ltz PHENYLALANINE-4-HYDR
OXYLASE
(Chromobacterium
violaceum) 		5 / 12 VAL A 118
LEU A 147
VAL A 183
ASP A 139
GLY A 142
 None
None
None
HBI  A 500 ( 4.9A)
None
 1.04A 1r9oA-1ltzA:
0.0		 1r9oA-1ltzA:
20.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RA2_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 1dr6 DIHYDROFOLATE
REDUCTASE
(Gallus
gallus) 		7 / 12 ILE A   7
ALA A   9
PHE A  34
ILE A  60
LEU A  67
TYR A 121
THR A 136
 HBI  A 198 (-4.1A)
HBI  A 198 ( 3.6A)
HBI  A 198 (-4.1A)
None
None
None
HBI  A 198 ( 4.5A)
 0.61A 1ra2A-1dr6A:
20.3		 1ra2A-1dr6A:
33.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RA3_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 1dr6 DIHYDROFOLATE
REDUCTASE
(Gallus
gallus) 		7 / 12 ILE A   7
ALA A   9
ILE A  60
LEU A  67
ARG A  70
TYR A 121
THR A 136
 HBI  A 198 (-4.1A)
HBI  A 198 ( 3.6A)
None
None
None
None
HBI  A 198 ( 4.5A)
 0.68A 1ra3A-1dr6A:
20.1		 1ra3A-1dr6A:
33.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RA8_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 1dr6 DIHYDROFOLATE
REDUCTASE
(Gallus
gallus) 		8 / 12 ILE A   7
ALA A   9
PHE A  34
THR A  56
ILE A  60
LEU A  67
TYR A 121
THR A 136
 HBI  A 198 (-4.1A)
HBI  A 198 ( 3.6A)
HBI  A 198 (-4.1A)
NAP  A 191 (-3.5A)
None
None
None
HBI  A 198 ( 4.5A)
 0.56A 1ra8A-1dr6A:
20.2		 1ra8A-1dr6A:
33.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RB2_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 1dr6 DIHYDROFOLATE
REDUCTASE
(Gallus
gallus) 		7 / 12 ILE A   7
ALA A   9
PHE A  34
ILE A  60
LEU A  67
TYR A 121
THR A 136
 HBI  A 198 (-4.1A)
HBI  A 198 ( 3.6A)
HBI  A 198 (-4.1A)
None
None
None
HBI  A 198 ( 4.5A)
 0.62A 1rb2A-1dr6A:
20.3		 1rb2A-1dr6A:
33.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RB2_B_FOLB161_0
(DIHYDROFOLATE
REDUCTASE)		 1dr6 DIHYDROFOLATE
REDUCTASE
(Gallus
gallus) 		7 / 12 ILE A   7
ALA A   9
PHE A  34
LEU A  67
ARG A  70
TYR A 121
THR A 136
 HBI  A 198 (-4.1A)
HBI  A 198 ( 3.6A)
HBI  A 198 (-4.1A)
None
None
None
HBI  A 198 ( 4.5A)
 0.37A 1rb2B-1dr6A:
20.3		 1rb2B-1dr6A:
33.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RB3_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 1dr6 DIHYDROFOLATE
REDUCTASE
(Gallus
gallus) 		6 / 10 ILE A   7
ALA A   9
ILE A  60
ARG A  70
TYR A 121
THR A 136
 HBI  A 198 (-4.1A)
HBI  A 198 ( 3.6A)
None
None
None
HBI  A 198 ( 4.5A)
 0.68A 1rb3A-1dr6A:
20.2		 1rb3A-1dr6A:
33.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RB3_B_MTXB161_1
(DIHYDROFOLATE
REDUCTASE)		 1dr6 DIHYDROFOLATE
REDUCTASE
(Gallus
gallus) 		7 / 12 ILE A   7
ALA A   9
SER A  59
ILE A  60
LEU A  67
ARG A  70
TYR A 121
 HBI  A 198 (-4.1A)
HBI  A 198 ( 3.6A)
NAP  A 191 ( 4.1A)
None
None
None
None
 0.71A 1rb3B-1dr6A:
20.2		 1rb3B-1dr6A:
33.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RB3_B_MTXB161_1
(DIHYDROFOLATE
REDUCTASE)		 1dr6 DIHYDROFOLATE
REDUCTASE
(Gallus
gallus) 		7 / 12 ILE A   7
ALA A   9
SER A  59
LEU A  67
ARG A  70
TYR A 121
THR A 136
 HBI  A 198 (-4.1A)
HBI  A 198 ( 3.6A)
NAP  A 191 ( 4.1A)
None
None
None
HBI  A 198 ( 4.5A)
 0.53A 1rb3B-1dr6A:
20.2		 1rb3B-1dr6A:
33.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RD7_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 1dr6 DIHYDROFOLATE
REDUCTASE
(Gallus
gallus) 		8 / 12 ILE A   7
ALA A   9
PHE A  34
THR A  56
ILE A  60
LEU A  67
TYR A 121
THR A 136
 HBI  A 198 (-4.1A)
HBI  A 198 ( 3.6A)
HBI  A 198 (-4.1A)
NAP  A 191 (-3.5A)
None
None
None
HBI  A 198 ( 4.5A)
 0.63A 1rd7A-1dr6A:
19.8		 1rd7A-1dr6A:
33.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RD7_B_FOLB361_0
(DIHYDROFOLATE
REDUCTASE)		 1dr6 DIHYDROFOLATE
REDUCTASE
(Gallus
gallus) 		7 / 12 ILE A   7
ALA A   9
THR A  56
ILE A  60
LEU A  67
TYR A 121
THR A 136
 HBI  A 198 (-4.1A)
HBI  A 198 ( 3.6A)
NAP  A 191 (-3.5A)
None
None
None
HBI  A 198 ( 4.5A)
 0.60A 1rd7B-1dr6A:
19.8		 1rd7B-1dr6A:
33.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RE7_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 1dr6 DIHYDROFOLATE
REDUCTASE
(Gallus
gallus) 		7 / 12 ILE A   7
ALA A   9
PHE A  34
THR A  56
ILE A  60
TYR A 121
THR A 136
 HBI  A 198 (-4.1A)
HBI  A 198 ( 3.6A)
HBI  A 198 (-4.1A)
NAP  A 191 (-3.5A)
None
None
HBI  A 198 ( 4.5A)
 0.52A 1re7A-1dr6A:
20.0		 1re7A-1dr6A:
33.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RE7_B_FOLB361_0
(DIHYDROFOLATE
REDUCTASE)		 1dr6 DIHYDROFOLATE
REDUCTASE
(Gallus
gallus) 		6 / 12 ILE A   7
ALA A   9
PHE A  34
LEU A  67
TYR A 121
THR A 136
 HBI  A 198 (-4.1A)
HBI  A 198 ( 3.6A)
HBI  A 198 (-4.1A)
None
None
HBI  A 198 ( 4.5A)
 0.49A 1re7B-1dr6A:
19.8		 1re7B-1dr6A:
33.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RE7_B_FOLB361_0
(DIHYDROFOLATE
REDUCTASE)		 1dr6 DIHYDROFOLATE
REDUCTASE
(Gallus
gallus) 		5 / 12 PHE A  34
ILE A  60
LEU A  67
TYR A 121
THR A 136
 HBI  A 198 (-4.1A)
None
None
None
HBI  A 198 ( 4.5A)
 0.67A 1re7B-1dr6A:
19.8		 1re7B-1dr6A:
33.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RG7_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 1dr6 DIHYDROFOLATE
REDUCTASE
(Gallus
gallus) 		6 / 12 ALA A   9
THR A  56
ILE A  60
LEU A  67
ARG A  70
TYR A 121
 HBI  A 198 ( 3.6A)
NAP  A 191 (-3.5A)
None
None
None
None
 0.58A 1rg7A-1dr6A:
18.6		 1rg7A-1dr6A:
33.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RG7_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 1dr6 DIHYDROFOLATE
REDUCTASE
(Gallus
gallus) 		5 / 12 ALA A   9
THR A  56
SER A  59
ILE A  60
TYR A 121
 HBI  A 198 ( 3.6A)
NAP  A 191 (-3.5A)
NAP  A 191 ( 4.1A)
None
None
 0.87A 1rg7A-1dr6A:
18.6		 1rg7A-1dr6A:
33.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_A_SAMA385_0
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 1ltz PHENYLALANINE-4-HYDR
OXYLASE
(Chromobacterium
violaceum) 		4 / 8 HIS A 138
PRO A 134
ASP A 139
PHE A 116
 FE  A 400 (-3.3A)
None
HBI  A 500 ( 4.9A)
None
 1.02A 1rg9A-1ltzA:
undetectable		 1rg9A-1ltzA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_B_SAMB485_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 1ltz PHENYLALANINE-4-HYDR
OXYLASE
(Chromobacterium
violaceum) 		4 / 8 HIS A 138
PRO A 134
ASP A 139
PHE A 116
 FE  A 400 (-3.3A)
None
HBI  A 500 ( 4.9A)
None
 1.03A 1rg9B-1ltzA:
undetectable		 1rg9B-1ltzA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_C_SAMC585_0
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 1ltz PHENYLALANINE-4-HYDR
OXYLASE
(Chromobacterium
violaceum) 		4 / 8 HIS A 138
PRO A 134
ASP A 139
PHE A 116
 FE  A 400 (-3.3A)
None
HBI  A 500 ( 4.9A)
None
 1.04A 1rg9C-1ltzA:
undetectable		 1rg9C-1ltzA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_C_SAMC685_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 1ltz PHENYLALANINE-4-HYDR
OXYLASE
(Chromobacterium
violaceum) 		4 / 8 HIS A 138
PRO A 134
ASP A 139
PHE A 116
 FE  A 400 (-3.3A)
None
HBI  A 500 ( 4.9A)
None
 1.04A 1rg9D-1ltzA:
undetectable		 1rg9D-1ltzA:
21.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RH3_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 1dr6 DIHYDROFOLATE
REDUCTASE
(Gallus
gallus) 		7 / 12 ILE A   7
PHE A  34
SER A  59
ILE A  60
LEU A  67
ARG A  70
TYR A 121
 HBI  A 198 (-4.1A)
HBI  A 198 (-4.1A)
NAP  A 191 ( 4.1A)
None
None
None
None
 0.70A 1rh3A-1dr6A:
20.7		 1rh3A-1dr6A:
33.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RX2_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 1dr6 DIHYDROFOLATE
REDUCTASE
(Gallus
gallus) 		7 / 12 ILE A   7
ALA A   9
PHE A  34
ILE A  60
LEU A  67
TYR A 121
THR A 136
 HBI  A 198 (-4.1A)
HBI  A 198 ( 3.6A)
HBI  A 198 (-4.1A)
None
None
None
HBI  A 198 ( 4.5A)
 0.65A 1rx2A-1dr6A:
21.2		 1rx2A-1dr6A:
33.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RX3_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 1dr6 DIHYDROFOLATE
REDUCTASE
(Gallus
gallus) 		8 / 12 ILE A   7
ALA A   9
PHE A  34
SER A  59
ILE A  60
LEU A  67
ARG A  70
TYR A 121
 HBI  A 198 (-4.1A)
HBI  A 198 ( 3.6A)
HBI  A 198 (-4.1A)
NAP  A 191 ( 4.1A)
None
None
None
None
 0.70A 1rx3A-1dr6A:
21.0		 1rx3A-1dr6A:
33.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RX7_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 1dr6 DIHYDROFOLATE
REDUCTASE
(Gallus
gallus) 		8 / 12 ILE A   7
ALA A   9
PHE A  34
THR A  56
ILE A  60
LEU A  67
TYR A 121
THR A 136
 HBI  A 198 (-4.1A)
HBI  A 198 ( 3.6A)
HBI  A 198 (-4.1A)
NAP  A 191 (-3.5A)
None
None
None
HBI  A 198 ( 4.5A)
 0.55A 1rx7A-1dr6A:
19.7		 1rx7A-1dr6A:
33.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RX8_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 1dr6 DIHYDROFOLATE
REDUCTASE
(Gallus
gallus) 		7 / 12 ILE A   7
ALA A   9
PHE A  34
ILE A  60
LEU A  67
TYR A 121
THR A 136
 HBI  A 198 (-4.1A)
HBI  A 198 ( 3.6A)
HBI  A 198 (-4.1A)
None
None
None
HBI  A 198 ( 4.5A)
 0.62A 1rx8A-1dr6A:
20.9		 1rx8A-1dr6A:
33.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1TDR_A_MTXA170_1
(TELLUROMETHIONYL
DIHYDROFOLATE
REDUCTASE)		 1dr6 DIHYDROFOLATE
REDUCTASE
(Gallus
gallus) 		8 / 12 ILE A   7
ALA A   9
PHE A  34
THR A  56
ILE A  60
LEU A  67
ARG A  70
TYR A 121
 HBI  A 198 (-4.1A)
HBI  A 198 ( 3.6A)
HBI  A 198 (-4.1A)
NAP  A 191 (-3.5A)
None
None
None
None
 0.71A 1tdrA-1dr6A:
20.0		 1tdrA-1dr6A:
32.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1TDR_B_MTXB170_1
(TELLUROMETHIONYL
DIHYDROFOLATE
REDUCTASE)		 1dr6 DIHYDROFOLATE
REDUCTASE
(Gallus
gallus) 		6 / 10 ALA A   9
ILE A  60
LEU A  67
ARG A  70
TYR A 121
THR A 136
 HBI  A 198 ( 3.6A)
None
None
None
None
HBI  A 198 ( 4.5A)
 0.76A 1tdrB-1dr6A:
20.4		 1tdrB-1dr6A:
32.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1U70_A_MTXA187_1
(DIHYDROFOLATE
REDUCTASE)		 1dr6 DIHYDROFOLATE
REDUCTASE
(Gallus
gallus) 		8 / 12 ILE A   7
ALA A   9
GLU A  30
PRO A  61
ASN A  64
LEU A  67
ARG A  70
TYR A 121
 HBI  A 198 (-4.1A)
HBI  A 198 ( 3.6A)
HBI  A 198 (-3.0A)
None
None
None
None
None
 0.61A 1u70A-1dr6A:
31.1		 1u70A-1dr6A:
75.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1U72_A_MTXA188_1
(DIHYDROFOLATE
REDUCTASE)		 1dr6 DIHYDROFOLATE
REDUCTASE
(Gallus
gallus) 		8 / 12 ALA A   9
LEU A  22
GLU A  30
SER A  59
LEU A  67
ARG A  70
VAL A 115
TYR A 121
 HBI  A 198 ( 3.6A)
NAP  A 191 ( 4.7A)
HBI  A 198 (-3.0A)
NAP  A 191 ( 4.1A)
None
None
HBI  A 198 ( 4.3A)
None
 0.39A 1u72A-1dr6A:
31.8		 1u72A-1dr6A:
74.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1U72_A_MTXA188_1
(DIHYDROFOLATE
REDUCTASE)		 1dr6 DIHYDROFOLATE
REDUCTASE
(Gallus
gallus) 		8 / 12 ALA A   9
LEU A  22
SER A  59
PRO A  61
ASN A  64
LEU A  67
VAL A 115
TYR A 121
 HBI  A 198 ( 3.6A)
NAP  A 191 ( 4.7A)
NAP  A 191 ( 4.1A)
None
None
None
HBI  A 198 ( 4.3A)
None
 0.73A 1u72A-1dr6A:
31.8		 1u72A-1dr6A:
74.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1U72_A_MTXA188_1
(DIHYDROFOLATE
REDUCTASE)		 1dr6 DIHYDROFOLATE
REDUCTASE
(Gallus
gallus) 		8 / 12 ALA A   9
LEU A  22
SER A  59
PRO A  61
LEU A  67
ARG A  70
VAL A 115
TYR A 121
 HBI  A 198 ( 3.6A)
NAP  A 191 ( 4.7A)
NAP  A 191 ( 4.1A)
None
None
None
HBI  A 198 ( 4.3A)
None
 0.56A 1u72A-1dr6A:
31.8		 1u72A-1dr6A:
74.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_D_CRND5401_1
(CREATININE
AMIDOHYDROLASE)		 2toh TYROSINE
3-MONOOXYGENASE
(Rattus
norvegicus) 		4 / 8 GLU A 376
HIS A 331
HIS A 336
GLU A 332
 FE  A 501 (-2.1A)
FE  A 501 ( 3.3A)
FE  A 501 ( 3.4A)
HBI  A 500 (-3.2A)
 0.99A 1v7zD-2tohA:
undetectable		 1v7zD-2tohA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_E_CRNE6401_1
(CREATININE
AMIDOHYDROLASE)		 2toh TYROSINE
3-MONOOXYGENASE
(Rattus
norvegicus) 		4 / 8 GLU A 376
HIS A 331
HIS A 336
GLU A 332
 FE  A 501 (-2.1A)
FE  A 501 ( 3.3A)
FE  A 501 ( 3.4A)
HBI  A 500 (-3.2A)
 0.99A 1v7zE-2tohA:
undetectable		 1v7zE-2tohA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_F_CRNF7401_1
(CREATININE
AMIDOHYDROLASE)		 2toh TYROSINE
3-MONOOXYGENASE
(Rattus
norvegicus) 		4 / 8 GLU A 376
HIS A 331
HIS A 336
GLU A 332
 FE  A 501 (-2.1A)
FE  A 501 ( 3.3A)
FE  A 501 ( 3.4A)
HBI  A 500 (-3.2A)
 0.97A 1v7zF-2tohA:
undetectable		 1v7zF-2tohA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z9H_A_IMNA379_1
(MEMBRANE-ASSOCIATED
PROSTAGLANDIN E
SYNTHASE-2)		 1dr6 DIHYDROFOLATE
REDUCTASE
(Gallus
gallus) 		5 / 12 THR A  38
TYR A 121
SER A   6
ILE A   7
VAL A  50
 None
None
None
HBI  A 198 (-4.1A)
None
 1.31A 1z9hA-1dr6A:
undetectable		 1z9hA-1dr6A:
23.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z9H_B_IMNB381_1
(MEMBRANE-ASSOCIATED
PROSTAGLANDIN E
SYNTHASE-2)		 1dr6 DIHYDROFOLATE
REDUCTASE
(Gallus
gallus) 		5 / 12 THR A  38
TYR A 121
SER A   6
ILE A   7
VAL A  50
 None
None
None
HBI  A 198 (-4.1A)
None
 1.31A 1z9hB-1dr6A:
undetectable		 1z9hB-1dr6A:
23.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z9H_C_IMNC379_1
(MEMBRANE-ASSOCIATED
PROSTAGLANDIN E
SYNTHASE-2)		 1dr6 DIHYDROFOLATE
REDUCTASE
(Gallus
gallus) 		5 / 12 THR A  38
TYR A 121
SER A   6
ILE A   7
VAL A  50
 None
None
None
HBI  A 198 (-4.1A)
None
 1.30A 1z9hC-1dr6A:
undetectable		 1z9hC-1dr6A:
23.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BL9_A_CP6A1240_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1dr6 DIHYDROFOLATE
REDUCTASE
(Gallus
gallus) 		8 / 12 ILE A   7
ALA A   9
LEU A  22
PHE A  34
SER A  59
ILE A  60
TYR A 121
THR A 136
 HBI  A 198 (-4.1A)
HBI  A 198 ( 3.6A)
NAP  A 191 ( 4.7A)
HBI  A 198 (-4.1A)
NAP  A 191 ( 4.1A)
None
None
HBI  A 198 ( 4.5A)
 0.46A 2bl9A-1dr6A:
22.8		 2bl9A-1dr6A:
28.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BLA_A_CP6A302_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1dr6 DIHYDROFOLATE
REDUCTASE
(Gallus
gallus) 		7 / 11 ILE A   7
ALA A   9
PHE A  34
SER A  59
ILE A  60
TYR A 121
THR A 136
 HBI  A 198 (-4.1A)
HBI  A 198 ( 3.6A)
HBI  A 198 (-4.1A)
NAP  A 191 ( 4.1A)
None
None
HBI  A 198 ( 4.5A)
 0.45A 2blaA-1dr6A:
22.5		 2blaA-1dr6A:
28.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2CD2_A_FOLA307_0
(DIHYDROFOLATE
REDUCTASE)		 1dr6 DIHYDROFOLATE
REDUCTASE
(Gallus
gallus) 		8 / 12 ILE A   7
ALA A   9
LEU A  22
THR A  56
LEU A  67
ARG A  70
TYR A 121
THR A 136
 HBI  A 198 (-4.1A)
HBI  A 198 ( 3.6A)
NAP  A 191 ( 4.7A)
NAP  A 191 (-3.5A)
None
None
None
HBI  A 198 ( 4.5A)
 0.47A 2cd2A-1dr6A:
25.4		 2cd2A-1dr6A:
39.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2CD2_A_FOLA307_0
(DIHYDROFOLATE
REDUCTASE)		 1dr6 DIHYDROFOLATE
REDUCTASE
(Gallus
gallus) 		8 / 12 ILE A   7
ALA A   9
THR A  56
PRO A  61
LEU A  67
ARG A  70
TYR A 121
THR A 136
 HBI  A 198 (-4.1A)
HBI  A 198 ( 3.6A)
NAP  A 191 (-3.5A)
None
None
None
None
HBI  A 198 ( 4.5A)
 0.54A 2cd2A-1dr6A:
25.4		 2cd2A-1dr6A:
39.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2D0K_A_FOLA1161_0
(DIHYDROFOLATE
REDUCTASE)		 1dr6 DIHYDROFOLATE
REDUCTASE
(Gallus
gallus) 		8 / 12 ILE A   7
ALA A   9
PHE A  34
ILE A  60
LEU A  67
ARG A  70
TYR A 121
THR A 136
 HBI  A 198 (-4.1A)
HBI  A 198 ( 3.6A)
HBI  A 198 (-4.1A)
None
None
None
None
HBI  A 198 ( 4.5A)
 0.39A 2d0kA-1dr6A:
19.7		 2d0kA-1dr6A:
33.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2D0K_B_FOLB2161_0
(DIHYDROFOLATE
REDUCTASE)		 1dr6 DIHYDROFOLATE
REDUCTASE
(Gallus
gallus) 		9 / 12 ILE A   7
ALA A   9
PHE A  34
THR A  56
ILE A  60
LEU A  67
ARG A  70
TYR A 121
THR A 136
 HBI  A 198 (-4.1A)
HBI  A 198 ( 3.6A)
HBI  A 198 (-4.1A)
NAP  A 191 (-3.5A)
None
None
None
None
HBI  A 198 ( 4.5A)
 0.46A 2d0kB-1dr6A:
19.8		 2d0kB-1dr6A:
33.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2DRC_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 1dr6 DIHYDROFOLATE
REDUCTASE
(Gallus
gallus) 		6 / 12 ILE A   7
ALA A   9
ILE A  60
LEU A  67
ARG A  70
TYR A 121
 HBI  A 198 (-4.1A)
HBI  A 198 ( 3.6A)
None
None
None
None
 0.67A 2drcA-1dr6A:
19.9		 2drcA-1dr6A:
33.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2DRC_B_MTXB161_1
(DIHYDROFOLATE
REDUCTASE)		 1dr6 DIHYDROFOLATE
REDUCTASE
(Gallus
gallus) 		7 / 12 ILE A   7
ALA A   9
ILE A  60
LEU A  67
ARG A  70
TYR A 121
THR A 136
 HBI  A 198 (-4.1A)
HBI  A 198 ( 3.6A)
None
None
None
None
HBI  A 198 ( 4.5A)
 0.66A 2drcB-1dr6A:
20.3		 2drcB-1dr6A:
33.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OBV_A_SAMA501_0
(S-ADENOSYLMETHIONINE
SYNTHETASE ISOFORM
TYPE-1)		 1ltz PHENYLALANINE-4-HYDR
OXYLASE
(Chromobacterium
violaceum) 		4 / 8 HIS A 138
PRO A 134
ASP A 139
PHE A 116
 FE  A 400 (-3.3A)
None
HBI  A 500 ( 4.9A)
None
 0.97A 2obvA-1ltzA:
undetectable		 2obvA-1ltzA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIP_A_MTXA605_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 1dr6 DIHYDROFOLATE
REDUCTASE
(Gallus
gallus) 		8 / 12 ALA A   9
LEU A  22
PHE A  34
THR A  56
ILE A  60
LEU A  67
ARG A  70
TYR A 121
 HBI  A 198 ( 3.6A)
NAP  A 191 ( 4.7A)
HBI  A 198 (-4.1A)
NAP  A 191 (-3.5A)
None
None
None
None
 0.75A 2oipA-1dr6A:
22.9		 2oipA-1dr6A:
16.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIP_B_MTXB609_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 1dr6 DIHYDROFOLATE
REDUCTASE
(Gallus
gallus) 		7 / 12 ALA A   9
LEU A  22
LYS A  32
PHE A  34
THR A  56
TYR A 121
THR A 136
 HBI  A 198 ( 3.6A)
NAP  A 191 ( 4.7A)
None
HBI  A 198 (-4.1A)
NAP  A 191 (-3.5A)
None
HBI  A 198 ( 4.5A)
 0.63A 2oipB-1dr6A:
21.1		 2oipB-1dr6A:
16.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIP_B_MTXB609_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 1dr6 DIHYDROFOLATE
REDUCTASE
(Gallus
gallus) 		8 / 12 ALA A   9
LEU A  22
PHE A  34
THR A  56
LEU A  67
ARG A  70
TYR A 121
THR A 136
 HBI  A 198 ( 3.6A)
NAP  A 191 ( 4.7A)
HBI  A 198 (-4.1A)
NAP  A 191 (-3.5A)
None
None
None
HBI  A 198 ( 4.5A)
 0.60A 2oipB-1dr6A:
21.1		 2oipB-1dr6A:
16.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIP_C_MTXC613_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 1dr6 DIHYDROFOLATE
REDUCTASE
(Gallus
gallus) 		8 / 12 ALA A   9
LEU A  22
PHE A  34
THR A  56
LEU A  67
ARG A  70
TYR A 121
THR A 136
 HBI  A 198 ( 3.6A)
NAP  A 191 ( 4.7A)
HBI  A 198 (-4.1A)
NAP  A 191 (-3.5A)
None
None
None
HBI  A 198 ( 4.5A)
 0.64A 2oipC-1dr6A:
22.6		 2oipC-1dr6A:
16.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIP_D_MTXD617_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 1dr6 DIHYDROFOLATE
REDUCTASE
(Gallus
gallus) 		8 / 12 ALA A   9
LEU A  22
PHE A  34
THR A  56
ILE A  60
LEU A  67
ARG A  70
TYR A 121
 HBI  A 198 ( 3.6A)
NAP  A 191 ( 4.7A)
HBI  A 198 (-4.1A)
NAP  A 191 (-3.5A)
None
None
None
None
 0.85A 2oipD-1dr6A:
23.3		 2oipD-1dr6A:
16.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIP_E_MTXE621_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 1dr6 DIHYDROFOLATE
REDUCTASE
(Gallus
gallus) 		5 / 12 ALA A   9
LEU A  22
LYS A  32
PHE A  34
TYR A 121
 HBI  A 198 ( 3.6A)
NAP  A 191 ( 4.7A)
None
HBI  A 198 (-4.1A)
None
 0.88A 2oipE-1dr6A:
22.1		 2oipE-1dr6A:
16.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIP_E_MTXE621_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 1dr6 DIHYDROFOLATE
REDUCTASE
(Gallus
gallus) 		8 / 12 ALA A   9
LEU A  22
PHE A  34
THR A  56
ILE A  60
LEU A  67
ARG A  70
TYR A 121
 HBI  A 198 ( 3.6A)
NAP  A 191 ( 4.7A)
HBI  A 198 (-4.1A)
NAP  A 191 (-3.5A)
None
None
None
None
 0.85A 2oipE-1dr6A:
22.1		 2oipE-1dr6A:
16.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2P02_A_SAMA2_0
(S-ADENOSYLMETHIONINE
SYNTHETASE ISOFORM
TYPE-2)		 1ltz PHENYLALANINE-4-HYDR
OXYLASE
(Chromobacterium
violaceum) 		4 / 8 HIS A 138
PRO A 134
ASP A 139
PHE A 116
 FE  A 400 (-3.3A)
None
HBI  A 500 ( 4.9A)
None
 0.99A 2p02A-1ltzA:
undetectable		 2p02A-1ltzA:
22.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2QK8_A_MTXA200_1
(DIHYDROFOLATE
REDUCTASE)		 1dr6 DIHYDROFOLATE
REDUCTASE
(Gallus
gallus) 		5 / 12 ALA A   9
GLU A  30
LEU A  67
ARG A  70
TYR A 121
 HBI  A 198 ( 3.6A)
HBI  A 198 (-3.0A)
None
None
None
 0.64A 2qk8A-1dr6A:
21.1		 2qk8A-1dr6A:
32.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W3A_A_TOPA1190_1
(DIHYDROFOLATE
REDUCTASE)		 1dr6 DIHYDROFOLATE
REDUCTASE
(Gallus
gallus) 		10 / 11 ILE A   7
ALA A   9
GLU A  30
PHE A  34
THR A  56
ILE A  60
PRO A  61
VAL A 115
TYR A 121
THR A 136
 HBI  A 198 (-4.1A)
HBI  A 198 ( 3.6A)
HBI  A 198 (-3.0A)
HBI  A 198 (-4.1A)
NAP  A 191 (-3.5A)
None
None
HBI  A 198 ( 4.3A)
None
HBI  A 198 ( 4.5A)
 0.32A 2w3aA-1dr6A:
32.5		 2w3aA-1dr6A:
74.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W3A_B_TOPB1189_1
(DIHYDROFOLATE
REDUCTASE)		 1dr6 DIHYDROFOLATE
REDUCTASE
(Gallus
gallus) 		9 / 10 ILE A   7
ALA A   9
GLU A  30
PHE A  34
THR A  56
ILE A  60
LEU A  67
TYR A 121
THR A 136
 HBI  A 198 (-4.1A)
HBI  A 198 ( 3.6A)
HBI  A 198 (-3.0A)
HBI  A 198 (-4.1A)
NAP  A 191 (-3.5A)
None
None
None
HBI  A 198 ( 4.5A)
 0.27A 2w3aB-1dr6A:
32.7		 2w3aB-1dr6A:
74.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W3B_A_FOLA401_0
(DIHYDROFOLATE
REDUCTASE)		 1dr6 DIHYDROFOLATE
REDUCTASE
(Gallus
gallus) 		6 / 12 ALA A   9
LEU A  22
ARG A  28
THR A  56
PRO A  61
THR A 136
 HBI  A 198 ( 3.6A)
NAP  A 191 ( 4.7A)
None
NAP  A 191 (-3.5A)
None
HBI  A 198 ( 4.5A)
 1.26A 2w3bA-1dr6A:
32.3		 2w3bA-1dr6A:
74.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W3B_A_FOLA401_0
(DIHYDROFOLATE
REDUCTASE)		 1dr6 DIHYDROFOLATE
REDUCTASE
(Gallus
gallus) 		10 / 12 ILE A   7
ALA A   9
LEU A  22
PHE A  34
THR A  56
ILE A  60
PRO A  61
LEU A  67
TYR A 121
THR A 136
 HBI  A 198 (-4.1A)
HBI  A 198 ( 3.6A)
NAP  A 191 ( 4.7A)
HBI  A 198 (-4.1A)
NAP  A 191 (-3.5A)
None
None
None
None
HBI  A 198 ( 4.5A)
 0.51A 2w3bA-1dr6A:
32.3		 2w3bA-1dr6A:
74.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W3B_B_FOLB401_0
(DIHYDROFOLATE
REDUCTASE)		 1dr6 DIHYDROFOLATE
REDUCTASE
(Gallus
gallus) 		10 / 12 ILE A   7
ALA A   9
LEU A  22
PHE A  34
ILE A  60
PRO A  61
ASN A  64
LEU A  67
TYR A 121
THR A 136
 HBI  A 198 (-4.1A)
HBI  A 198 ( 3.6A)
NAP  A 191 ( 4.7A)
HBI  A 198 (-4.1A)
None
None
None
None
None
HBI  A 198 ( 4.5A)
 0.62A 2w3bB-1dr6A:
32.3		 2w3bB-1dr6A:
74.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W3M_A_FOLA1188_0
(DIHYDROFOLATE
REDUCTASE)		 1dr6 DIHYDROFOLATE
REDUCTASE
(Gallus
gallus) 		10 / 12 ILE A   7
ALA A   9
LEU A  22
PHE A  34
ILE A  60
PRO A  61
ASN A  64
LEU A  67
TYR A 121
THR A 136
 HBI  A 198 (-4.1A)
HBI  A 198 ( 3.6A)
NAP  A 191 ( 4.7A)
HBI  A 198 (-4.1A)
None
None
None
None
None
HBI  A 198 ( 4.5A)
 0.57A 2w3mA-1dr6A:
32.3		 2w3mA-1dr6A:
74.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W3M_B_FOLB1188_0
(DIHYDROFOLATE
REDUCTASE)		 1dr6 DIHYDROFOLATE
REDUCTASE
(Gallus
gallus) 		10 / 12 ILE A   7
ALA A   9
LEU A  22
GLU A  30
PHE A  34
ASN A  64
LEU A  67
ARG A  70
TYR A 121
THR A 136
 HBI  A 198 (-4.1A)
HBI  A 198 ( 3.6A)
NAP  A 191 ( 4.7A)
HBI  A 198 (-3.0A)
HBI  A 198 (-4.1A)
None
None
None
None
HBI  A 198 ( 4.5A)
 0.54A 2w3mB-1dr6A:
32.6		 2w3mB-1dr6A:
74.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9G_A_TOPA1159_1
(DIHYDROFOLATE
REDUCTASE)		 1dr6 DIHYDROFOLATE
REDUCTASE
(Gallus
gallus) 		5 / 10 ALA A   9
LEU A  22
SER A  59
ILE A  60
THR A 136
 HBI  A 198 ( 3.6A)
NAP  A 191 ( 4.7A)
NAP  A 191 ( 4.1A)
None
HBI  A 198 ( 4.5A)
 0.93A 2w9gA-1dr6A:
20.4		 2w9gA-1dr6A:
27.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W9S_A_TOPA1160_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 1dr6 DIHYDROFOLATE
REDUCTASE
(Gallus
gallus) 		6 / 11 ILE A   7
ALA A   9
LEU A  22
SER A  59
TYR A 121
THR A 136
 HBI  A 198 (-4.1A)
HBI  A 198 ( 3.6A)
NAP  A 191 ( 4.7A)
NAP  A 191 ( 4.1A)
None
HBI  A 198 ( 4.5A)
 0.64A 2w9sA-1dr6A:
20.4		 2w9sA-1dr6A:
30.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W9S_A_TOPA1160_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 1dr6 DIHYDROFOLATE
REDUCTASE
(Gallus
gallus) 		5 / 11 ILE A   7
ALA A   9
SER A  59
ILE A  60
TYR A 121
 HBI  A 198 (-4.1A)
HBI  A 198 ( 3.6A)
NAP  A 191 ( 4.1A)
None
None
 0.92A 2w9sA-1dr6A:
20.4		 2w9sA-1dr6A:
30.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W9S_B_TOPB1160_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 1dr6 DIHYDROFOLATE
REDUCTASE
(Gallus
gallus) 		6 / 11 ILE A   7
ALA A   9
LEU A  22
SER A  59
ILE A  60
TYR A 121
 HBI  A 198 (-4.1A)
HBI  A 198 ( 3.6A)
NAP  A 191 ( 4.7A)
NAP  A 191 ( 4.1A)
None
None
 0.88A 2w9sB-1dr6A:
20.3		 2w9sB-1dr6A:
30.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W9S_B_TOPB1160_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 1dr6 DIHYDROFOLATE
REDUCTASE
(Gallus
gallus) 		6 / 11 ILE A   7
ALA A   9
LEU A  22
SER A  59
TYR A 121
THR A 136
 HBI  A 198 (-4.1A)
HBI  A 198 ( 3.6A)
NAP  A 191 ( 4.7A)
NAP  A 191 ( 4.1A)
None
HBI  A 198 ( 4.5A)
 0.64A 2w9sB-1dr6A:
20.3		 2w9sB-1dr6A:
30.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W9S_C_TOPC1160_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 1dr6 DIHYDROFOLATE
REDUCTASE
(Gallus
gallus) 		6 / 10 ILE A   7
ALA A   9
LEU A  22
SER A  59
TYR A 121
THR A 136
 HBI  A 198 (-4.1A)
HBI  A 198 ( 3.6A)
NAP  A 191 ( 4.7A)
NAP  A 191 ( 4.1A)
None
HBI  A 198 ( 4.5A)
 0.64A 2w9sC-1dr6A:
20.4		 2w9sC-1dr6A:
30.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W9S_C_TOPC1160_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 1dr6 DIHYDROFOLATE
REDUCTASE
(Gallus
gallus) 		5 / 10 ILE A   7
ALA A   9
SER A  59
ILE A  60
TYR A 121
 HBI  A 198 (-4.1A)
HBI  A 198 ( 3.6A)
NAP  A 191 ( 4.1A)
None
None
 0.91A 2w9sC-1dr6A:
20.4		 2w9sC-1dr6A:
30.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W9S_D_TOPD1158_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 1dr6 DIHYDROFOLATE
REDUCTASE
(Gallus
gallus) 		6 / 10 ILE A   7
ALA A   9
LEU A  22
SER A  59
TYR A 121
THR A 136
 HBI  A 198 (-4.1A)
HBI  A 198 ( 3.6A)
NAP  A 191 ( 4.7A)
NAP  A 191 ( 4.1A)
None
HBI  A 198 ( 4.5A)
 0.44A 2w9sD-1dr6A:
19.9		 2w9sD-1dr6A:
30.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W9S_E_TOPE1160_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 1dr6 DIHYDROFOLATE
REDUCTASE
(Gallus
gallus) 		5 / 8 ILE A   7
ALA A   9
LEU A  22
TYR A 121
THR A 136
 HBI  A 198 (-4.1A)
HBI  A 198 ( 3.6A)
NAP  A 191 ( 4.7A)
None
HBI  A 198 ( 4.5A)
 0.45A 2w9sE-1dr6A:
19.9		 2w9sE-1dr6A:
30.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W9S_F_TOPF1159_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 1dr6 DIHYDROFOLATE
REDUCTASE
(Gallus
gallus) 		6 / 10 ILE A   7
ALA A   9
LEU A  22
SER A  59
TYR A 121
THR A 136
 HBI  A 198 (-4.1A)
HBI  A 198 ( 3.6A)
NAP  A 191 ( 4.7A)
NAP  A 191 ( 4.1A)
None
HBI  A 198 ( 4.5A)
 0.43A 2w9sF-1dr6A:
19.8		 2w9sF-1dr6A:
30.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X8Z_A_X8ZA1615_1
(ANGIOTENSIN
CONVERTING ENZYME)		 2toh TYROSINE
3-MONOOXYGENASE
(Rattus
norvegicus) 		5 / 11 GLU A 332
HIS A 331
GLU A 376
LYS A 301
TYR A 371
 HBI  A 500 (-3.2A)
FE  A 501 ( 3.3A)
FE  A 501 (-2.1A)
MTY  A 300 ( 2.9A)
MTY  A 300 (-3.9A)
 1.23A 2x8zA-2tohA:
undetectable		 2x8zA-2tohA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XAD_E_GCSE710_1
(N-ACYL GLM
PEUDO-TEICOPLANIN
DEACETYLASE
TEICOPLANIN)		 1ltz PHENYLALANINE-4-HYDR
OXYLASE
(Chromobacterium
violaceum) 		4 / 8 HIS A 138
TRP A 180
HIS A 143
ASP A 139
 FE  A 400 (-3.3A)
None
FE  A 400 (-3.4A)
HBI  A 500 ( 4.9A)
 1.09A 2xadA-1ltzA:
undetectable		 2xadA-1ltzA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XAD_F_GCSF710_1
(N-ACYL GLM
PEUDO-TEICOPLANIN
DEACETYLASE
TEICOPLANIN)		 1ltz PHENYLALANINE-4-HYDR
OXYLASE
(Chromobacterium
violaceum) 		4 / 8 HIS A 138
TRP A 180
HIS A 143
ASP A 139
 FE  A 400 (-3.3A)
None
FE  A 400 (-3.4A)
HBI  A 500 ( 4.9A)
 1.12A 2xadB-1ltzA:
undetectable		 2xadB-1ltzA:
22.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ZZA_A_FOLA164_0
(DIHYDROFOLATE
REDUCTASE)		 1dr6 DIHYDROFOLATE
REDUCTASE
(Gallus
gallus) 		8 / 12 ILE A   7
ALA A   9
GLU A  30
ILE A  60
LEU A  67
ARG A  70
TYR A 121
THR A 136
 HBI  A 198 (-4.1A)
HBI  A 198 ( 3.6A)
HBI  A 198 (-3.0A)
None
None
None
None
HBI  A 198 ( 4.5A)
 0.71A 2zzaA-1dr6A:
21.3		 2zzaA-1dr6A:
33.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ZZA_B_FOLB164_0
(DIHYDROFOLATE
REDUCTASE)		 1dr6 DIHYDROFOLATE
REDUCTASE
(Gallus
gallus) 		8 / 11 ILE A   7
ALA A   9
GLU A  30
ILE A  60
LEU A  67
ARG A  70
TYR A 121
THR A 136
 HBI  A 198 (-4.1A)
HBI  A 198 ( 3.6A)
HBI  A 198 (-3.0A)
None
None
None
None
HBI  A 198 ( 4.5A)
 0.70A 2zzaB-1dr6A:
21.3		 2zzaB-1dr6A:
33.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_B_CRNB304_1
(CREATININE
AMIDOHYDROLASE)		 2toh TYROSINE
3-MONOOXYGENASE
(Rattus
norvegicus) 		4 / 7 GLU A 376
HIS A 331
HIS A 336
GLU A 332
 FE  A 501 (-2.1A)
FE  A 501 ( 3.3A)
FE  A 501 ( 3.4A)
HBI  A 500 (-3.2A)
 0.93A 3a6jB-2tohA:
undetectable		 3a6jB-2tohA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_C_CRNC305_1
(CREATININE
AMIDOHYDROLASE)		 2toh TYROSINE
3-MONOOXYGENASE
(Rattus
norvegicus) 		4 / 8 GLU A 376
HIS A 331
HIS A 336
GLU A 332
 FE  A 501 (-2.1A)
FE  A 501 ( 3.3A)
FE  A 501 ( 3.4A)
HBI  A 500 (-3.2A)
 0.94A 3a6jC-2tohA:
undetectable		 3a6jC-2tohA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_E_CRNE306_1
(CREATININE
AMIDOHYDROLASE)		 2toh TYROSINE
3-MONOOXYGENASE
(Rattus
norvegicus) 		4 / 8 GLU A 376
HIS A 331
HIS A 336
GLU A 332
 FE  A 501 (-2.1A)
FE  A 501 ( 3.3A)
FE  A 501 ( 3.4A)
HBI  A 500 (-3.2A)
 0.97A 3a6jE-2tohA:
undetectable		 3a6jE-2tohA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_F_CRNF307_1
(CREATININE
AMIDOHYDROLASE)		 2toh TYROSINE
3-MONOOXYGENASE
(Rattus
norvegicus) 		4 / 8 GLU A 376
HIS A 331
HIS A 336
GLU A 332
 FE  A 501 (-2.1A)
FE  A 501 ( 3.3A)
FE  A 501 ( 3.4A)
HBI  A 500 (-3.2A)
 0.93A 3a6jF-2tohA:
undetectable		 3a6jF-2tohA:
21.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CD2_A_MTXA307_1
(DIHYDROFOLATE
REDUCTASE)		 1dr6 DIHYDROFOLATE
REDUCTASE
(Gallus
gallus) 		6 / 12 ILE A   7
LEU A  22
GLU A  30
LEU A  67
ARG A  70
TYR A 121
 HBI  A 198 (-4.1A)
NAP  A 191 ( 4.7A)
HBI  A 198 (-3.0A)
None
None
None
 0.50A 3cd2A-1dr6A:
25.0		 3cd2A-1dr6A:
39.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CD2_A_MTXA307_1
(DIHYDROFOLATE
REDUCTASE)		 1dr6 DIHYDROFOLATE
REDUCTASE
(Gallus
gallus) 		6 / 12 ILE A   7
LEU A  22
PRO A  61
LEU A  67
ARG A  70
TYR A 121
 HBI  A 198 (-4.1A)
NAP  A 191 ( 4.7A)
None
None
None
None
 0.69A 3cd2A-1dr6A:
25.0		 3cd2A-1dr6A:
39.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CL9_A_MTXA602_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE (DHFR-TS))		 1dr6 DIHYDROFOLATE
REDUCTASE
(Gallus
gallus) 		6 / 12 ALA A   9
THR A  56
PRO A  61
LEU A  67
ARG A  70
TYR A 121
 HBI  A 198 ( 3.6A)
NAP  A 191 (-3.5A)
None
None
None
None
 0.51A 3cl9A-1dr6A:
21.9		 3cl9A-1dr6A:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CL9_A_MTXA602_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE (DHFR-TS))		 1dr6 DIHYDROFOLATE
REDUCTASE
(Gallus
gallus) 		6 / 12 ALA A   9
THR A  56
SER A  59
PRO A  61
LEU A  67
TYR A 121
 HBI  A 198 ( 3.6A)
NAP  A 191 (-3.5A)
NAP  A 191 ( 4.1A)
None
None
None
 0.75A 3cl9A-1dr6A:
21.9		 3cl9A-1dr6A:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLB_A_TMQA611_1
(DHFR-TS)		 1dr6 DIHYDROFOLATE
REDUCTASE
(Gallus
gallus) 		6 / 11 ALA A   9
ILE A  60
PRO A  61
LEU A  67
TYR A 121
THR A 136
 HBI  A 198 ( 3.6A)
None
None
None
None
HBI  A 198 ( 4.5A)
 0.54A 3clbA-1dr6A:
22.5		 3clbA-1dr6A:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLB_B_TMQB612_1
(DHFR-TS)		 1dr6 DIHYDROFOLATE
REDUCTASE
(Gallus
gallus) 		7 / 12 ALA A   9
PHE A  34
THR A  56
SER A  59
ILE A  60
PRO A  61
TYR A 121
 HBI  A 198 ( 3.6A)
HBI  A 198 (-4.1A)
NAP  A 191 (-3.5A)
NAP  A 191 ( 4.1A)
None
None
None
 0.59A 3clbB-1dr6A:
21.4		 3clbB-1dr6A:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLB_C_TMQC613_1
(DHFR-TS)		 1dr6 DIHYDROFOLATE
REDUCTASE
(Gallus
gallus) 		7 / 12 ALA A   9
THR A  56
ILE A  60
PRO A  61
LEU A  67
TYR A 121
THR A 136
 HBI  A 198 ( 3.6A)
NAP  A 191 (-3.5A)
None
None
None
None
HBI  A 198 ( 4.5A)
 0.53A 3clbC-1dr6A:
22.3		 3clbC-1dr6A:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLB_D_TMQD614_1
(DHFR-TS)		 1dr6 DIHYDROFOLATE
REDUCTASE
(Gallus
gallus) 		5 / 10 ALA A   9
ILE A  60
PRO A  61
TYR A 121
THR A 136
 HBI  A 198 ( 3.6A)
None
None
None
HBI  A 198 ( 4.5A)
 0.52A 3clbD-1dr6A:
22.2		 3clbD-1dr6A:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CO4_A_GCSA401_1
(CHITINASE)		 1dcp DCOH
(Rattus
norvegicus) 		3 / 3 GLU A  65
HIS A  63
HIS A  62
 None
HBI  A 105 (-3.6A)
HBI  A 105 (-3.8A)
 0.91A 3co4A-1dcpA:
undetectable		 3co4A-1dcpA:
15.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3DAT_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 1dr6 DIHYDROFOLATE
REDUCTASE
(Gallus
gallus) 		6 / 12 ALA A   9
LEU A  22
GLU A  30
LEU A  67
ARG A  70
TYR A 121
 HBI  A 198 ( 3.6A)
NAP  A 191 ( 4.7A)
HBI  A 198 (-3.0A)
None
None
None
 0.69A 3datA-1dr6A:
21.3		 3datA-1dr6A:
32.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3DAT_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 1dr6 DIHYDROFOLATE
REDUCTASE
(Gallus
gallus) 		6 / 12 ALA A   9
LEU A  22
ILE A  60
LEU A  67
ARG A  70
TYR A 121
 HBI  A 198 ( 3.6A)
NAP  A 191 ( 4.7A)
None
None
None
None
 0.86A 3datA-1dr6A:
21.3		 3datA-1dr6A:
32.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3DAU_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 1dr6 DIHYDROFOLATE
REDUCTASE
(Gallus
gallus) 		6 / 12 ILE A   7
ALA A   9
ILE A  60
LEU A  67
ARG A  70
TYR A 121
 HBI  A 198 (-4.1A)
HBI  A 198 ( 3.6A)
None
None
None
None
 0.62A 3dauA-1dr6A:
20.8		 3dauA-1dr6A:
33.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3DFR_A_MTXA164_1
(DIHYDROFOLATE
REDUCTASE)		 1dr6 DIHYDROFOLATE
REDUCTASE
(Gallus
gallus) 		6 / 12 ALA A   9
LEU A  22
SER A  59
LEU A  67
ARG A  70
THR A 136
 HBI  A 198 ( 3.6A)
NAP  A 191 ( 4.7A)
NAP  A 191 ( 4.1A)
None
None
HBI  A 198 ( 4.5A)
 0.56A 3dfrA-1dr6A:
21.5		 3dfrA-1dr6A:
34.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3DFR_A_MTXA164_1
(DIHYDROFOLATE
REDUCTASE)		 1dr6 DIHYDROFOLATE
REDUCTASE
(Gallus
gallus) 		5 / 12 ALA A   9
LEU A  22
SER A  59
PRO A  61
THR A 136
 HBI  A 198 ( 3.6A)
NAP  A 191 ( 4.7A)
NAP  A 191 ( 4.1A)
None
HBI  A 198 ( 4.5A)
 0.75A 3dfrA-1dr6A:
21.5		 3dfrA-1dr6A:
34.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3DRC_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 1dr6 DIHYDROFOLATE
REDUCTASE
(Gallus
gallus) 		6 / 12 ILE A   7
ALA A   9
ILE A  60
LEU A  67
ARG A  70
TYR A 121
 HBI  A 198 (-4.1A)
HBI  A 198 ( 3.6A)
None
None
None
None
 0.67A 3drcA-1dr6A:
20.0		 3drcA-1dr6A:
33.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3DRC_B_MTXB361_1
(DIHYDROFOLATE
REDUCTASE)		 1dr6 DIHYDROFOLATE
REDUCTASE
(Gallus
gallus) 		7 / 12 ILE A   7
ALA A   9
ILE A  60
LEU A  67
ARG A  70
TYR A 121
THR A 136
 HBI  A 198 (-4.1A)
HBI  A 198 ( 3.6A)
None
None
None
None
HBI  A 198 ( 4.5A)
 0.65A 3drcB-1dr6A:
20.4		 3drcB-1dr6A:
33.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3EIG_A_MTXA200_1
(DIHYDROFOLATE
REDUCTASE)		 1dr6 DIHYDROFOLATE
REDUCTASE
(Gallus
gallus) 		8 / 12 ILE A   7
ALA A   9
LEU A  22
GLU A  30
SER A  59
ASN A  64
LEU A  67
TYR A 121
 HBI  A 198 (-4.1A)
HBI  A 198 ( 3.6A)
NAP  A 191 ( 4.7A)
HBI  A 198 (-3.0A)
NAP  A 191 ( 4.1A)
None
None
None
 0.77A 3eigA-1dr6A:
30.5		 3eigA-1dr6A:
74.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3EIG_A_MTXA200_1
(DIHYDROFOLATE
REDUCTASE)		 1dr6 DIHYDROFOLATE
REDUCTASE
(Gallus
gallus) 		8 / 12 ILE A   7
ALA A   9
LEU A  22
GLU A  30
SER A  59
LEU A  67
ARG A  70
TYR A 121
 HBI  A 198 (-4.1A)
HBI  A 198 ( 3.6A)
NAP  A 191 ( 4.7A)
HBI  A 198 (-3.0A)
NAP  A 191 ( 4.1A)
None
None
None
 0.44A 3eigA-1dr6A:
30.5		 3eigA-1dr6A:
74.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3EIG_A_MTXA200_1
(DIHYDROFOLATE
REDUCTASE)		 1dr6 DIHYDROFOLATE
REDUCTASE
(Gallus
gallus) 		8 / 12 ILE A   7
ALA A   9
LEU A  22
SER A  59
PRO A  61
ASN A  64
LEU A  67
TYR A 121
 HBI  A 198 (-4.1A)
HBI  A 198 ( 3.6A)
NAP  A 191 ( 4.7A)
NAP  A 191 ( 4.1A)
None
None
None
None
 0.77A 3eigA-1dr6A:
30.5		 3eigA-1dr6A:
74.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3EIG_A_MTXA200_1
(DIHYDROFOLATE
REDUCTASE)		 1dr6 DIHYDROFOLATE
REDUCTASE
(Gallus
gallus) 		8 / 12 ILE A   7
ALA A   9
LEU A  22
SER A  59
PRO A  61
LEU A  67
ARG A  70
TYR A 121
 HBI  A 198 (-4.1A)
HBI  A 198 ( 3.6A)
NAP  A 191 ( 4.7A)
NAP  A 191 ( 4.1A)
None
None
None
None
 0.59A 3eigA-1dr6A:
30.5		 3eigA-1dr6A:
74.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3FL9_B_TOPB200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 1dr6 DIHYDROFOLATE
REDUCTASE
(Gallus
gallus) 		7 / 12 ALA A   9
ASN A  21
LEU A  22
GLU A  30
LEU A  67
TYR A 121
THR A 136
 HBI  A 198 ( 3.6A)
None
NAP  A 191 ( 4.7A)
HBI  A 198 (-3.0A)
None
None
HBI  A 198 ( 4.5A)
 1.00A 3fl9B-1dr6A:
20.1		 3fl9B-1dr6A:
32.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3FL9_C_TOPC200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 1dr6 DIHYDROFOLATE
REDUCTASE
(Gallus
gallus) 		5 / 11 ALA A   9
ASN A  21
GLU A  30
LEU A  67
THR A 136
 HBI  A 198 ( 3.6A)
None
HBI  A 198 (-3.0A)
None
HBI  A 198 ( 4.5A)
 0.86A 3fl9C-1dr6A:
20.2		 3fl9C-1dr6A:
32.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3FL9_D_TOPD200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 1dr6 DIHYDROFOLATE
REDUCTASE
(Gallus
gallus) 		5 / 9 ALA A   9
LEU A  22
GLU A  30
LEU A  67
TYR A 121
 HBI  A 198 ( 3.6A)
NAP  A 191 ( 4.7A)
HBI  A 198 (-3.0A)
None
None
 0.79A 3fl9D-1dr6A:
20.4		 3fl9D-1dr6A:
32.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3FL9_E_TOPE200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 1dr6 DIHYDROFOLATE
REDUCTASE
(Gallus
gallus) 		5 / 10 ALA A   9
LEU A  22
GLU A  30
LEU A  67
THR A 136
 HBI  A 198 ( 3.6A)
NAP  A 191 ( 4.7A)
HBI  A 198 (-3.0A)
None
HBI  A 198 ( 4.5A)
 0.67A 3fl9E-1dr6A:
20.1		 3fl9E-1dr6A:
32.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3FL9_F_TOPF200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 1dr6 DIHYDROFOLATE
REDUCTASE
(Gallus
gallus) 		5 / 10 ALA A   9
ASN A  21
LEU A  22
GLU A  30
LEU A  67
 HBI  A 198 ( 3.6A)
None
NAP  A 191 ( 4.7A)
HBI  A 198 (-3.0A)
None
 0.97A 3fl9F-1dr6A:
20.4		 3fl9F-1dr6A:
32.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3FL9_G_TOPG200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 1dr6 DIHYDROFOLATE
REDUCTASE
(Gallus
gallus) 		7 / 12 ALA A   9
ASN A  21
LEU A  22
GLU A  30
LEU A  67
TYR A 121
THR A 136
 HBI  A 198 ( 3.6A)
None
NAP  A 191 ( 4.7A)
HBI  A 198 (-3.0A)
None
None
HBI  A 198 ( 4.5A)
 0.96A 3fl9G-1dr6A:
20.0		 3fl9G-1dr6A:
32.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRB_X_TOPX300_1
(DIHYDROFOLATE
REDUCTASE)		 1dr6 DIHYDROFOLATE
REDUCTASE
(Gallus
gallus) 		6 / 11 ALA A   9
LEU A  22
SER A  59
ILE A  60
TYR A 121
THR A 136
 HBI  A 198 ( 3.6A)
NAP  A 191 ( 4.7A)
NAP  A 191 ( 4.1A)
None
None
HBI  A 198 ( 4.5A)
 0.85A 3frbX-1dr6A:
20.2		 3frbX-1dr6A:
28.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRE_X_TOPX300_1
(DIHYDROFOLATE
REDUCTASE)		 1dr6 DIHYDROFOLATE
REDUCTASE
(Gallus
gallus) 		5 / 9 ALA A   9
LEU A  22
SER A  59
ILE A  60
THR A 136
 HBI  A 198 ( 3.6A)
NAP  A 191 ( 4.7A)
NAP  A 191 ( 4.1A)
None
HBI  A 198 ( 4.5A)
 0.91A 3freX-1dr6A:
20.2		 3freX-1dr6A:
27.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HBB_A_TMQA611_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1dr6 DIHYDROFOLATE
REDUCTASE
(Gallus
gallus) 		5 / 10 ALA A   9
ILE A  60
PRO A  61
LEU A  67
TYR A 121
 HBI  A 198 ( 3.6A)
None
None
None
None
 0.50A 3hbbA-1dr6A:
22.6		 3hbbA-1dr6A:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HBB_C_TMQC613_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1dr6 DIHYDROFOLATE
REDUCTASE
(Gallus
gallus) 		6 / 11 ALA A   9
ILE A  60
PRO A  61
LEU A  67
TYR A 121
THR A 136
 HBI  A 198 ( 3.6A)
None
None
None
None
HBI  A 198 ( 4.5A)
 0.56A 3hbbC-1dr6A:
22.2		 3hbbC-1dr6A:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HBB_D_TMQD614_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1dr6 DIHYDROFOLATE
REDUCTASE
(Gallus
gallus) 		5 / 10 ALA A   9
ILE A  60
PRO A  61
TYR A 121
THR A 136
 HBI  A 198 ( 3.6A)
None
None
None
HBI  A 198 ( 4.5A)
 0.46A 3hbbD-1dr6A:
22.4		 3hbbD-1dr6A:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJ3_A_MTXA605_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 1dr6 DIHYDROFOLATE
REDUCTASE
(Gallus
gallus) 		8 / 12 ALA A   9
LEU A  22
PHE A  34
THR A  56
LEU A  67
ARG A  70
TYR A 121
THR A 136
 HBI  A 198 ( 3.6A)
NAP  A 191 ( 4.7A)
HBI  A 198 (-4.1A)
NAP  A 191 (-3.5A)
None
None
None
HBI  A 198 ( 4.5A)
 0.65A 3hj3A-1dr6A:
23.6		 3hj3A-1dr6A:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJ3_A_MTXA605_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 1dr6 DIHYDROFOLATE
REDUCTASE
(Gallus
gallus) 		8 / 12 ALA A   9
PHE A  34
THR A  56
ILE A  60
LEU A  67
ARG A  70
TYR A 121
THR A 136
 HBI  A 198 ( 3.6A)
HBI  A 198 (-4.1A)
NAP  A 191 (-3.5A)
None
None
None
None
HBI  A 198 ( 4.5A)
 0.88A 3hj3A-1dr6A:
23.6		 3hj3A-1dr6A:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJ3_B_MTXB609_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 1dr6 DIHYDROFOLATE
REDUCTASE
(Gallus
gallus) 		7 / 12 ALA A   9
LEU A  22
LYS A  32
PHE A  34
THR A  56
ILE A  60
TYR A 121
 HBI  A 198 ( 3.6A)
NAP  A 191 ( 4.7A)
None
HBI  A 198 (-4.1A)
NAP  A 191 (-3.5A)
None
None
 0.92A 3hj3B-1dr6A:
23.5		 3hj3B-1dr6A:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJ3_B_MTXB609_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 1dr6 DIHYDROFOLATE
REDUCTASE
(Gallus
gallus) 		8 / 12 ALA A   9
LEU A  22
PHE A  34
THR A  56
ILE A  60
LEU A  67
ARG A  70
TYR A 121
 HBI  A 198 ( 3.6A)
NAP  A 191 ( 4.7A)
HBI  A 198 (-4.1A)
NAP  A 191 (-3.5A)
None
None
None
None
 0.79A 3hj3B-1dr6A:
23.5		 3hj3B-1dr6A:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJ3_C_MTXC613_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 1dr6 DIHYDROFOLATE
REDUCTASE
(Gallus
gallus) 		8 / 12 ALA A   9
LEU A  22
PHE A  34
THR A  56
LEU A  67
ARG A  70
TYR A 121
THR A 136
 HBI  A 198 ( 3.6A)
NAP  A 191 ( 4.7A)
HBI  A 198 (-4.1A)
NAP  A 191 (-3.5A)
None
None
None
HBI  A 198 ( 4.5A)
 0.74A 3hj3C-1dr6A:
6.4		 3hj3C-1dr6A:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJ3_D_MTXD615_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 1dr6 DIHYDROFOLATE
REDUCTASE
(Gallus
gallus) 		8 / 12 ALA A   9
LEU A  22
PHE A  34
THR A  56
ILE A  60
LEU A  67
ARG A  70
TYR A 121
 HBI  A 198 ( 3.6A)
NAP  A 191 ( 4.7A)
HBI  A 198 (-4.1A)
NAP  A 191 (-3.5A)
None
None
None
None
 0.85A 3hj3D-1dr6A:
19.1		 3hj3D-1dr6A:
17.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3IA4_A_MTXA164_1
(DIHYDROFOLATE
REDUCTASE)		 1dr6 DIHYDROFOLATE
REDUCTASE
(Gallus
gallus) 		7 / 12 ALA A   9
GLU A  30
SER A  59
ILE A  60
LEU A  67
ARG A  70
TYR A 121
 HBI  A 198 ( 3.6A)
HBI  A 198 (-3.0A)
NAP  A 191 ( 4.1A)
None
None
None
None
 0.93A 3ia4A-1dr6A:
21.0		 3ia4A-1dr6A:
32.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3IA4_B_MTXB164_1
(DIHYDROFOLATE
REDUCTASE)		 1dr6 DIHYDROFOLATE
REDUCTASE
(Gallus
gallus) 		8 / 12 ILE A   7
ALA A   9
GLU A  30
SER A  59
ILE A  60
LEU A  67
ARG A  70
TYR A 121
 HBI  A 198 (-4.1A)
HBI  A 198 ( 3.6A)
HBI  A 198 (-3.0A)
NAP  A 191 ( 4.1A)
None
None
None
None
 0.90A 3ia4B-1dr6A:
21.1		 3ia4B-1dr6A:
32.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3IA4_C_MTXC164_1
(DIHYDROFOLATE
REDUCTASE)		 1dr6 DIHYDROFOLATE
REDUCTASE
(Gallus
gallus) 		8 / 12 ALA A   9
GLU A  30
PHE A  34
SER A  59
ILE A  60
LEU A  67
ARG A  70
TYR A 121
 HBI  A 198 ( 3.6A)
HBI  A 198 (-3.0A)
HBI  A 198 (-4.1A)
NAP  A 191 ( 4.1A)
None
None
None
None
 0.85A 3ia4C-1dr6A:
21.1		 3ia4C-1dr6A:
32.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3IA4_D_MTXD164_1
(DIHYDROFOLATE
REDUCTASE)		 1dr6 DIHYDROFOLATE
REDUCTASE
(Gallus
gallus) 		9 / 12 ILE A   7
ALA A   9
GLU A  30
PHE A  34
SER A  59
ILE A  60
LEU A  67
ARG A  70
TYR A 121
 HBI  A 198 (-4.1A)
HBI  A 198 ( 3.6A)
HBI  A 198 (-3.0A)
HBI  A 198 (-4.1A)
NAP  A 191 ( 4.1A)
None
None
None
None
 0.85A 3ia4D-1dr6A:
21.1		 3ia4D-1dr6A:
32.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3IX9_A_MTXA200_1
(DIHYDROFOLATE
REDUCTASE)		 1dr6 DIHYDROFOLATE
REDUCTASE
(Gallus
gallus) 		8 / 12 ILE A   7
ALA A   9
LEU A  22
GLU A  30
LEU A  67
ARG A  70
VAL A 115
THR A 136
 HBI  A 198 (-4.1A)
HBI  A 198 ( 3.6A)
NAP  A 191 ( 4.7A)
HBI  A 198 (-3.0A)
None
None
HBI  A 198 ( 4.3A)
HBI  A 198 ( 4.5A)
 0.66A 3ix9A-1dr6A:
21.3		 3ix9A-1dr6A:
31.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3IX9_B_MTXB200_1
(DIHYDROFOLATE
REDUCTASE)		 1dr6 DIHYDROFOLATE
REDUCTASE
(Gallus
gallus) 		8 / 12 ILE A   7
ALA A   9
LEU A  22
GLU A  30
LEU A  67
ARG A  70
VAL A 115
THR A 136
 HBI  A 198 (-4.1A)
HBI  A 198 ( 3.6A)
NAP  A 191 ( 4.7A)
HBI  A 198 (-3.0A)
None
None
HBI  A 198 ( 4.3A)
HBI  A 198 ( 4.5A)
 0.70A 3ix9B-1dr6A:
20.8		 3ix9B-1dr6A:
31.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3JW3_A_TOPA208_1
(DIHYDROFOLATE
REDUCTASE)		 1dr6 DIHYDROFOLATE
REDUCTASE
(Gallus
gallus) 		5 / 10 ALA A   9
GLU A  30
ILE A  60
LEU A  67
THR A 136
 HBI  A 198 ( 3.6A)
HBI  A 198 (-3.0A)
None
None
HBI  A 198 ( 4.5A)
 1.18A 3jw3A-1dr6A:
21.3		 3jw3A-1dr6A:
31.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3JW3_A_TOPA208_1
(DIHYDROFOLATE
REDUCTASE)		 1dr6 DIHYDROFOLATE
REDUCTASE
(Gallus
gallus) 		5 / 10 ALA A   9
GLU A  30
ILE A  60
TYR A 121
THR A 136
 HBI  A 198 ( 3.6A)
HBI  A 198 (-3.0A)
None
None
HBI  A 198 ( 4.5A)
 0.80A 3jw3A-1dr6A:
21.3		 3jw3A-1dr6A:
31.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3JW3_B_TOPB208_1
(DIHYDROFOLATE
REDUCTASE)		 1dr6 DIHYDROFOLATE
REDUCTASE
(Gallus
gallus) 		5 / 9 ALA A   9
GLU A  30
ILE A  60
LEU A  67
TYR A 121
 HBI  A 198 ( 3.6A)
HBI  A 198 (-3.0A)
None
None
None
 1.17A 3jw3B-1dr6A:
21.4		 3jw3B-1dr6A:
31.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3JW3_B_TOPB208_1
(DIHYDROFOLATE
REDUCTASE)		 1dr6 DIHYDROFOLATE
REDUCTASE
(Gallus
gallus) 		5 / 9 ALA A   9
LEU A  22
GLU A  30
LEU A  67
TYR A 121
 HBI  A 198 ( 3.6A)
NAP  A 191 ( 4.7A)
HBI  A 198 (-3.0A)
None
None
 0.76A 3jw3B-1dr6A:
21.4		 3jw3B-1dr6A:
31.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3JW5_B_TOPB208_1
(DIHYDROFOLATE
REDUCTASE)		 1dr6 DIHYDROFOLATE
REDUCTASE
(Gallus
gallus) 		5 / 10 ALA A   9
GLU A  30
ILE A  60
LEU A  67
THR A 136
 HBI  A 198 ( 3.6A)
HBI  A 198 (-3.0A)
None
None
HBI  A 198 ( 4.5A)
 0.86A 3jw5B-1dr6A:
21.3		 3jw5B-1dr6A:
31.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3JW5_B_TOPB208_1
(DIHYDROFOLATE
REDUCTASE)		 1dr6 DIHYDROFOLATE
REDUCTASE
(Gallus
gallus) 		5 / 10 ALA A   9
LEU A  22
GLU A  30
LEU A  67
THR A 136
 HBI  A 198 ( 3.6A)
NAP  A 191 ( 4.7A)
HBI  A 198 (-3.0A)
None
HBI  A 198 ( 4.5A)
 0.59A 3jw5B-1dr6A:
21.3		 3jw5B-1dr6A:
31.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_A_LYAA514_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 1dr6 DIHYDROFOLATE
REDUCTASE
(Gallus
gallus) 		6 / 12 ALA A   9
THR A  56
ILE A  60
LEU A  67
ARG A  70
TYR A 121
 HBI  A 198 ( 3.6A)
NAP  A 191 (-3.5A)
None
None
None
None
 0.70A 3k2hA-1dr6A:
24.5		 3k2hA-1dr6A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_B_LYAB514_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 1dr6 DIHYDROFOLATE
REDUCTASE
(Gallus
gallus) 		6 / 12 ALA A   9
SER A  59
ILE A  60
LEU A  67
ARG A  70
TYR A 121
 HBI  A 198 ( 3.6A)
NAP  A 191 ( 4.1A)
None
None
None
None
 0.76A 3k2hB-1dr6A:
23.6		 3k2hB-1dr6A:
20.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3N0H_A_TOPA187_1
(DIHYDROFOLATE
REDUCTASE)		 1dr6 DIHYDROFOLATE
REDUCTASE
(Gallus
gallus) 		10 / 11 ILE A   7
ALA A   9
GLU A  30
PHE A  34
THR A  56
ILE A  60
LEU A  67
VAL A 115
TYR A 121
THR A 136
 HBI  A 198 (-4.1A)
HBI  A 198 ( 3.6A)
HBI  A 198 (-3.0A)
HBI  A 198 (-4.1A)
NAP  A 191 (-3.5A)
None
None
HBI  A 198 ( 4.3A)
None
HBI  A 198 ( 4.5A)
 0.40A 3n0hA-1dr6A:
31.7		 3n0hA-1dr6A:
73.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NRR_A_D16A520_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1dr6 DIHYDROFOLATE
REDUCTASE
(Gallus
gallus) 		5 / 12 ALA A   9
THR A  56
ILE A  60
PRO A  61
THR A 136
 HBI  A 198 ( 3.6A)
NAP  A 191 (-3.5A)
None
None
HBI  A 198 ( 4.5A)
 0.56A 3nrrA-1dr6A:
23.9		 3nrrA-1dr6A:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NRR_B_D16B520_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1dr6 DIHYDROFOLATE
REDUCTASE
(Gallus
gallus) 		5 / 12 ALA A   9
THR A  56
ILE A  60
PRO A  61
THR A 136
 HBI  A 198 ( 3.6A)
NAP  A 191 (-3.5A)
None
None
HBI  A 198 ( 4.5A)
 0.58A 3nrrB-1dr6A:
24.7		 3nrrB-1dr6A:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PO7_A_ZONA601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		 1ltz PHENYLALANINE-4-HYDR
OXYLASE
(Chromobacterium
violaceum) 		4 / 8 TYR A 179
LEU A 250
TYR A 155
PHE A 152
 HBI  A 500 ( 4.0A)
None
None
None
 1.33A 3po7A-1ltzA:
undetectable		 3po7A-1ltzA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PO7_B_ZONB601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		 1ltz PHENYLALANINE-4-HYDR
OXYLASE
(Chromobacterium
violaceum) 		5 / 9 TYR A 179
LEU A 250
ILE A 227
PHE A 152
TYR A 197
 HBI  A 500 ( 4.0A)
None
None
None
None
 1.41A 3po7B-1ltzA:
0.0		 3po7B-1ltzA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QFX_A_CP6A602_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1dr6 DIHYDROFOLATE
REDUCTASE
(Gallus
gallus) 		6 / 12 ALA A   9
PHE A  34
THR A  56
SER A  59
TYR A 121
THR A 136
 HBI  A 198 ( 3.6A)
HBI  A 198 (-4.1A)
NAP  A 191 (-3.5A)
NAP  A 191 ( 4.1A)
None
HBI  A 198 ( 4.5A)
 0.40A 3qfxA-1dr6A:
22.3		 3qfxA-1dr6A:
29.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QFX_B_CP6B702_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1dr6 DIHYDROFOLATE
REDUCTASE
(Gallus
gallus) 		6 / 12 ALA A   9
PHE A  34
THR A  56
SER A  59
TYR A 121
THR A 136
 HBI  A 198 ( 3.6A)
HBI  A 198 (-4.1A)
NAP  A 191 (-3.5A)
NAP  A 191 ( 4.1A)
None
HBI  A 198 ( 4.5A)
 0.40A 3qfxB-1dr6A:
22.3		 3qfxB-1dr6A:
29.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QG2_A_CP6A609_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1dr6 DIHYDROFOLATE
REDUCTASE
(Gallus
gallus) 		7 / 10 ILE A   7
ALA A   9
PHE A  34
SER A  59
ILE A  60
TYR A 121
THR A 136
 HBI  A 198 (-4.1A)
HBI  A 198 ( 3.6A)
HBI  A 198 (-4.1A)
NAP  A 191 ( 4.1A)
None
None
HBI  A 198 ( 4.5A)
 0.33A 3qg2A-1dr6A:
23.0		 3qg2A-1dr6A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QG2_B_CP6B709_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1dr6 DIHYDROFOLATE
REDUCTASE
(Gallus
gallus) 		7 / 11 ILE A   7
ALA A   9
PHE A  34
SER A  59
ILE A  60
TYR A 121
THR A 136
 HBI  A 198 (-4.1A)
HBI  A 198 ( 3.6A)
HBI  A 198 (-4.1A)
NAP  A 191 ( 4.1A)
None
None
HBI  A 198 ( 4.5A)
 0.30A 3qg2B-1dr6A:
22.9		 3qg2B-1dr6A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QGT_A_CP6A609_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1dr6 DIHYDROFOLATE
REDUCTASE
(Gallus
gallus) 		7 / 10 ILE A   7
ALA A   9
PHE A  34
SER A  59
ILE A  60
TYR A 121
THR A 136
 HBI  A 198 (-4.1A)
HBI  A 198 ( 3.6A)
HBI  A 198 (-4.1A)
NAP  A 191 ( 4.1A)
None
None
HBI  A 198 ( 4.5A)
 0.41A 3qgtA-1dr6A:
22.7		 3qgtA-1dr6A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QGT_B_CP6B609_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1dr6 DIHYDROFOLATE
REDUCTASE
(Gallus
gallus) 		5 / 10 ALA A   9
PHE A  34
SER A  59
ILE A  60
THR A 136
 HBI  A 198 ( 3.6A)
HBI  A 198 (-4.1A)
NAP  A 191 ( 4.1A)
None
HBI  A 198 ( 4.5A)
 1.28A 3qgtB-1dr6A:
22.4		 3qgtB-1dr6A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QGT_B_CP6B609_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1dr6 DIHYDROFOLATE
REDUCTASE
(Gallus
gallus) 		7 / 10 ILE A   7
ALA A   9
PHE A  34
SER A  59
ILE A  60
TYR A 121
THR A 136
 HBI  A 198 (-4.1A)
HBI  A 198 ( 3.6A)
HBI  A 198 (-4.1A)
NAP  A 191 ( 4.1A)
None
None
HBI  A 198 ( 4.5A)
 0.34A 3qgtB-1dr6A:
22.4		 3qgtB-1dr6A:
14.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QL0_A_FOLA160_0
(DIHYDROFOLATE
REDUCTASE)		 1dr6 DIHYDROFOLATE
REDUCTASE
(Gallus
gallus) 		8 / 12 ILE A   7
ALA A   9
PHE A  34
ILE A  60
LEU A  67
ARG A  70
TYR A 121
THR A 136
 HBI  A 198 (-4.1A)
HBI  A 198 ( 3.6A)
HBI  A 198 (-4.1A)
None
None
None
None
HBI  A 198 ( 4.5A)
 0.66A 3ql0A-1dr6A:
21.6		 3ql0A-1dr6A:
34.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QL3_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 1dr6 DIHYDROFOLATE
REDUCTASE
(Gallus
gallus) 		6 / 12 ILE A   7
ALA A   9
ILE A  60
ARG A  70
TYR A 121
THR A 136
 HBI  A 198 (-4.1A)
HBI  A 198 ( 3.6A)
None
None
None
HBI  A 198 ( 4.5A)
 0.69A 3ql3A-1dr6A:
21.3		 3ql3A-1dr6A:
33.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3S3V_A_TOPA187_1
(DIHYDROFOLATE
REDUCTASE)		 1dr6 DIHYDROFOLATE
REDUCTASE
(Gallus
gallus) 		10 / 12 ILE A   7
ALA A   9
GLU A  30
PHE A  34
THR A  56
ILE A  60
LEU A  67
VAL A 115
TYR A 121
THR A 136
 HBI  A 198 (-4.1A)
HBI  A 198 ( 3.6A)
HBI  A 198 (-3.0A)
HBI  A 198 (-4.1A)
NAP  A 191 (-3.5A)
None
None
HBI  A 198 ( 4.3A)
None
HBI  A 198 ( 4.5A)
 0.40A 3s3vA-1dr6A:
31.5		 3s3vA-1dr6A:
73.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TQ8_A_TOPA2001_1
(DIHYDROFOLATE
REDUCTASE)		 1dr6 DIHYDROFOLATE
REDUCTASE
(Gallus
gallus) 		7 / 9 ILE A   7
ALA A   9
LEU A  22
PHE A  34
SER A  59
ILE A  60
THR A 136
 HBI  A 198 (-4.1A)
HBI  A 198 ( 3.6A)
NAP  A 191 ( 4.7A)
HBI  A 198 (-4.1A)
NAP  A 191 ( 4.1A)
None
HBI  A 198 ( 4.5A)
 0.79A 3tq8A-1dr6A:
21.3		 3tq8A-1dr6A:
31.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TQ9_A_MTXA2001_1
(DIHYDROFOLATE
REDUCTASE)		 1dr6 DIHYDROFOLATE
REDUCTASE
(Gallus
gallus) 		8 / 12 ILE A   7
ALA A   9
LEU A  22
SER A  59
ILE A  60
LEU A  67
ARG A  70
THR A 136
 HBI  A 198 (-4.1A)
HBI  A 198 ( 3.6A)
NAP  A 191 ( 4.7A)
NAP  A 191 ( 4.1A)
None
None
None
HBI  A 198 ( 4.5A)
 0.83A 3tq9A-1dr6A:
21.4		 3tq9A-1dr6A:
31.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TQB_A_FOLA2001_0
(DIHYDROFOLATE
REDUCTASE)		 1dr6 DIHYDROFOLATE
REDUCTASE
(Gallus
gallus) 		7 / 11 ALA A   9
LEU A  22
THR A  56
ILE A  60
LEU A  67
ARG A  70
THR A 136
 HBI  A 198 ( 3.6A)
NAP  A 191 ( 4.7A)
NAP  A 191 (-3.5A)
None
None
None
HBI  A 198 ( 4.5A)
 0.62A 3tqbA-1dr6A:
21.4		 3tqbA-1dr6A:
31.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UM5_A_CP6A609_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1dr6 DIHYDROFOLATE
REDUCTASE
(Gallus
gallus) 		7 / 10 ILE A   7
PHE A  34
THR A  56
SER A  59
ILE A  60
TYR A 121
THR A 136
 HBI  A 198 (-4.1A)
HBI  A 198 (-4.1A)
NAP  A 191 (-3.5A)
NAP  A 191 ( 4.1A)
None
None
HBI  A 198 ( 4.5A)
 0.37A 3um5A-1dr6A:
22.7		 3um5A-1dr6A:
14.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UM5_A_CP6A609_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1dr6 DIHYDROFOLATE
REDUCTASE
(Gallus
gallus) 		5 / 10 VAL A   8
PHE A  34
THR A  56
SER A  59
ILE A  60
 NAP  A 191 (-3.7A)
HBI  A 198 (-4.1A)
NAP  A 191 (-3.5A)
NAP  A 191 ( 4.1A)
None
 1.35A 3um5A-1dr6A:
22.7		 3um5A-1dr6A:
14.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UM5_B_CP6B709_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1dr6 DIHYDROFOLATE
REDUCTASE
(Gallus
gallus) 		7 / 10 ILE A   7
PHE A  34
THR A  56
SER A  59
ILE A  60
TYR A 121
THR A 136
 HBI  A 198 (-4.1A)
HBI  A 198 (-4.1A)
NAP  A 191 (-3.5A)
NAP  A 191 ( 4.1A)
None
None
HBI  A 198 ( 4.5A)
 0.43A 3um5B-1dr6A:
12.7		 3um5B-1dr6A:
14.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7B_B_HAEB1270_1
(COLLAGENASE 3)		 1dmw PHENYLALANINE
HYDROXYLASE
(Homo
sapiens) 		4 / 5 LEU A 248
HIS A 285
GLU A 286
HIS A 290
 HBI  A 700 ( 4.5A)
FE  A 425 (-3.4A)
None
FE  A 425 (-3.3A)
 1.23A 4a7bB-1dmwA:
undetectable		 4a7bB-1dmwA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7B_B_HAEB1270_1
(COLLAGENASE 3)		 2toh TYROSINE
3-MONOOXYGENASE
(Rattus
norvegicus) 		4 / 5 LEU A 294
HIS A 331
GLU A 332
HIS A 336
 HBI  A 500 (-4.7A)
FE  A 501 ( 3.3A)
HBI  A 500 (-3.2A)
FE  A 501 ( 3.4A)
 1.08A 4a7bB-2tohA:
undetectable		 4a7bB-2tohA:
21.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4CD2_A_FOLA207_0
(DIHYDROFOLATE
REDUCTASE)		 1dr6 DIHYDROFOLATE
REDUCTASE
(Gallus
gallus) 		9 / 12 ILE A   7
ALA A   9
GLU A  30
PHE A  34
THR A  56
LEU A  67
ARG A  70
TYR A 121
THR A 136
 HBI  A 198 (-4.1A)
HBI  A 198 ( 3.6A)
HBI  A 198 (-3.0A)
HBI  A 198 (-4.1A)
NAP  A 191 (-3.5A)
None
None
None
HBI  A 198 ( 4.5A)
 0.35A 4cd2A-1dr6A:
24.0		 4cd2A-1dr6A:
39.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4DFR_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 1dr6 DIHYDROFOLATE
REDUCTASE
(Gallus
gallus) 		7 / 12 ILE A   7
ALA A   9
THR A  56
ILE A  60
LEU A  67
ARG A  70
TYR A 121
 HBI  A 198 (-4.1A)
HBI  A 198 ( 3.6A)
NAP  A 191 (-3.5A)
None
None
None
None
 0.66A 4dfrA-1dr6A:
19.8		 4dfrA-1dr6A:
32.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4DFR_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 1dr6 DIHYDROFOLATE
REDUCTASE
(Gallus
gallus) 		5 / 12 ILE A   7
ALA A   9
THR A  56
SER A  59
TYR A 121
 HBI  A 198 (-4.1A)
HBI  A 198 ( 3.6A)
NAP  A 191 (-3.5A)
NAP  A 191 ( 4.1A)
None
 0.85A 4dfrA-1dr6A:
19.8		 4dfrA-1dr6A:
32.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4DFR_B_MTXB162_1
(DIHYDROFOLATE
REDUCTASE)		 1dr6 DIHYDROFOLATE
REDUCTASE
(Gallus
gallus) 		7 / 12 ILE A   7
ALA A   9
ILE A  60
LEU A  67
ARG A  70
TYR A 121
THR A 136
 HBI  A 198 (-4.1A)
HBI  A 198 ( 3.6A)
None
None
None
None
HBI  A 198 ( 4.5A)
 0.66A 4dfrB-1dr6A:
20.3		 4dfrB-1dr6A:
32.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ECK_A_FOLA703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1dr6 DIHYDROFOLATE
REDUCTASE
(Gallus
gallus) 		6 / 12 ALA A   9
LEU A  22
PHE A  34
LEU A  67
ARG A  70
THR A 136
 HBI  A 198 ( 3.6A)
NAP  A 191 ( 4.7A)
HBI  A 198 (-4.1A)
None
None
HBI  A 198 ( 4.5A)
 0.53A 4eckA-1dr6A:
22.1		 4eckA-1dr6A:
16.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ECK_B_FOLB703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1dr6 DIHYDROFOLATE
REDUCTASE
(Gallus
gallus) 		7 / 12 ALA A   9
LEU A  22
PHE A  34
LEU A  67
ARG A  70
VAL A 115
THR A 136
 HBI  A 198 ( 3.6A)
NAP  A 191 ( 4.7A)
HBI  A 198 (-4.1A)
None
None
HBI  A 198 ( 4.3A)
HBI  A 198 ( 4.5A)
 0.66A 4eckB-1dr6A:
21.6		 4eckB-1dr6A:
16.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIL_A_FOLA703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1dr6 DIHYDROFOLATE
REDUCTASE
(Gallus
gallus) 		5 / 11 ALA A   9
LEU A  67
ARG A  70
VAL A 115
THR A 136
 HBI  A 198 ( 3.6A)
None
None
HBI  A 198 ( 4.3A)
HBI  A 198 ( 4.5A)
 0.40A 4eilA-1dr6A:
24.6		 4eilA-1dr6A:
17.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIL_B_FOLB703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1dr6 DIHYDROFOLATE
REDUCTASE
(Gallus
gallus) 		5 / 10 ALA A   9
LEU A  67
ARG A  70
VAL A 115
THR A 136
 HBI  A 198 ( 3.6A)
None
None
HBI  A 198 ( 4.3A)
HBI  A 198 ( 4.5A)
 0.42A 4eilB-1dr6A:
23.6		 4eilB-1dr6A:
17.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIL_C_FOLC703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1dr6 DIHYDROFOLATE
REDUCTASE
(Gallus
gallus) 		5 / 11 ALA A   9
LEU A  67
ARG A  70
VAL A 115
THR A 136
 HBI  A 198 ( 3.6A)
None
None
HBI  A 198 ( 4.3A)
HBI  A 198 ( 4.5A)
 0.39A 4eilC-1dr6A:
24.7		 4eilC-1dr6A:
17.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIL_E_FOLE703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1dr6 DIHYDROFOLATE
REDUCTASE
(Gallus
gallus) 		5 / 11 ALA A   9
LEU A  67
ARG A  70
VAL A 115
THR A 136
 HBI  A 198 ( 3.6A)
None
None
HBI  A 198 ( 4.3A)
HBI  A 198 ( 4.5A)
 0.37A 4eilE-1dr6A:
25.4		 4eilE-1dr6A:
17.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4EJ1_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1dr6 DIHYDROFOLATE
REDUCTASE
(Gallus
gallus) 		7 / 12 ILE A   7
ALA A   9
PHE A  34
THR A  56
ILE A  60
LEU A  67
TYR A 121
 HBI  A 198 (-4.1A)
HBI  A 198 ( 3.6A)
HBI  A 198 (-4.1A)
NAP  A 191 (-3.5A)
None
None
None
 0.59A 4ej1A-1dr6A:
19.7		 4ej1A-1dr6A:
33.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4EJ1_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 1dr6 DIHYDROFOLATE
REDUCTASE
(Gallus
gallus) 		8 / 12 ILE A   7
ALA A   9
PHE A  34
THR A  56
ILE A  60
LEU A  67
TYR A 121
THR A 136
 HBI  A 198 (-4.1A)
HBI  A 198 ( 3.6A)
HBI  A 198 (-4.1A)
NAP  A 191 (-3.5A)
None
None
None
HBI  A 198 ( 4.5A)
 0.54A 4ej1B-1dr6A:
19.6		 4ej1B-1dr6A:
33.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FHB_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1dr6 DIHYDROFOLATE
REDUCTASE
(Gallus
gallus) 		9 / 12 ILE A   7
ALA A   9
PHE A  34
THR A  56
ILE A  60
LEU A  67
ARG A  70
TYR A 121
THR A 136
 HBI  A 198 (-4.1A)
HBI  A 198 ( 3.6A)
HBI  A 198 (-4.1A)
NAP  A 191 (-3.5A)
None
None
None
None
HBI  A 198 ( 4.5A)
 0.66A 4fhbA-1dr6A:
20.4		 4fhbA-1dr6A:
33.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4G8Z_X_TOPX301_1
(DIHYDROFOLATE
REDUCTASE)		 1dr6 DIHYDROFOLATE
REDUCTASE
(Gallus
gallus) 		9 / 10 ILE A   7
ALA A   9
LEU A  22
GLU A  30
PHE A  34
SER A  59
PRO A  61
TYR A 121
THR A 136
 HBI  A 198 (-4.1A)
HBI  A 198 ( 3.6A)
NAP  A 191 ( 4.7A)
HBI  A 198 (-3.0A)
HBI  A 198 (-4.1A)
NAP  A 191 ( 4.1A)
None
None
HBI  A 198 ( 4.5A)
 0.64A 4g8zX-1dr6A:
25.2		 4g8zX-1dr6A:
39.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4GH8_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 1dr6 DIHYDROFOLATE
REDUCTASE
(Gallus
gallus) 		8 / 12 ILE A   7
ALA A   9
SER A  59
ILE A  60
PRO A  61
LEU A  67
ARG A  70
TYR A 121
 HBI  A 198 (-4.1A)
HBI  A 198 ( 3.6A)
NAP  A 191 ( 4.1A)
None
None
None
None
None
 0.63A 4gh8A-1dr6A:
21.9		 4gh8A-1dr6A:
36.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4GH8_B_MTXB201_1
(DIHYDROFOLATE
REDUCTASE)		 1dr6 DIHYDROFOLATE
REDUCTASE
(Gallus
gallus) 		6 / 12 ALA A   9
SER A  59
ILE A  60
PRO A  61
ASN A  64
TYR A 121
 HBI  A 198 ( 3.6A)
NAP  A 191 ( 4.1A)
None
None
None
None
 1.03A 4gh8B-1dr6A:
21.6		 4gh8B-1dr6A:
36.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4GH8_B_MTXB201_1
(DIHYDROFOLATE
REDUCTASE)		 1dr6 DIHYDROFOLATE
REDUCTASE
(Gallus
gallus) 		7 / 12 ILE A   7
ALA A   9
SER A  59
ILE A  60
PRO A  61
ARG A  70
TYR A 121
 HBI  A 198 (-4.1A)
HBI  A 198 ( 3.6A)
NAP  A 191 ( 4.1A)
None
None
None
None
 0.62A 4gh8B-1dr6A:
21.6		 4gh8B-1dr6A:
36.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4I13_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1dr6 DIHYDROFOLATE
REDUCTASE
(Gallus
gallus) 		7 / 12 ILE A   7
ALA A   9
PHE A  34
THR A  56
ILE A  60
LEU A  67
TYR A 121
 HBI  A 198 (-4.1A)
HBI  A 198 ( 3.6A)
HBI  A 198 (-4.1A)
NAP  A 191 (-3.5A)
None
None
None
 0.52A 4i13A-1dr6A:
19.8		 4i13A-1dr6A:
33.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4I1N_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1dr6 DIHYDROFOLATE
REDUCTASE
(Gallus
gallus) 		7 / 11 ILE A   7
ALA A   9
PHE A  34
LEU A  67
ARG A  70
TYR A 121
THR A 136
 HBI  A 198 (-4.1A)
HBI  A 198 ( 3.6A)
HBI  A 198 (-4.1A)
None
None
None
HBI  A 198 ( 4.5A)
 0.46A 4i1nA-1dr6A:
19.7		 4i1nA-1dr6A:
33.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KEB_B_FOLB202_0
(DIHYDROFOLATE
REDUCTASE)		 1dr6 DIHYDROFOLATE
REDUCTASE
(Gallus
gallus) 		10 / 12 ILE A   7
ALA A   9
LEU A  22
PHE A  34
THR A  56
ILE A  60
ASN A  64
LEU A  67
TYR A 121
THR A 136
 HBI  A 198 (-4.1A)
HBI  A 198 ( 3.6A)
NAP  A 191 ( 4.7A)
HBI  A 198 (-4.1A)
NAP  A 191 (-3.5A)
None
None
None
None
HBI  A 198 ( 4.5A)
 0.54A 4kebB-1dr6A:
32.5		 4kebB-1dr6A:
74.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KFJ_B_FOLB202_0
(DIHYDROFOLATE
REDUCTASE)		 1dr6 DIHYDROFOLATE
REDUCTASE
(Gallus
gallus) 		10 / 12 ILE A   7
ALA A   9
LEU A  22
PHE A  34
ILE A  60
PRO A  61
LEU A  67
VAL A 115
TYR A 121
THR A 136
 HBI  A 198 (-4.1A)
HBI  A 198 ( 3.6A)
NAP  A 191 ( 4.7A)
HBI  A 198 (-4.1A)
None
None
None
HBI  A 198 ( 4.3A)
None
HBI  A 198 ( 4.5A)
 0.45A 4kfjB-1dr6A:
32.7		 4kfjB-1dr6A:
74.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KFJ_B_FOLB202_1
(DIHYDROFOLATE
REDUCTASE)		 1dr6 DIHYDROFOLATE
REDUCTASE
(Gallus
gallus) 		4 / 4 GLU A  30
GLN A  35
ASN A  64
ARG A  70
 HBI  A 198 (-3.0A)
None
None
None
 1.49A 4kfjB-1dr6A:
32.7		 4kfjB-1dr6A:
74.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KJJ_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1dr6 DIHYDROFOLATE
REDUCTASE
(Gallus
gallus) 		7 / 12 ILE A   7
ALA A   9
PHE A  34
THR A  56
ILE A  60
LEU A  67
TYR A 121
 HBI  A 198 (-4.1A)
HBI  A 198 ( 3.6A)
HBI  A 198 (-4.1A)
NAP  A 191 (-3.5A)
None
None
None
 0.63A 4kjjA-1dr6A:
20.2		 4kjjA-1dr6A:
33.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KJK_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1dr6 DIHYDROFOLATE
REDUCTASE
(Gallus
gallus) 		7 / 12 ILE A   7
ALA A   9
PHE A  34
THR A  56
ILE A  60
LEU A  67
TYR A 121
 HBI  A 198 (-4.1A)
HBI  A 198 ( 3.6A)
HBI  A 198 (-4.1A)
NAP  A 191 (-3.5A)
None
None
None
 0.65A 4kjkA-1dr6A:
21.0		 4kjkA-1dr6A:
33.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KJL_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1dr6 DIHYDROFOLATE
REDUCTASE
(Gallus
gallus) 		8 / 12 ILE A   7
ALA A   9
PHE A  34
THR A  56
ILE A  60
LEU A  67
TYR A 121
THR A 136
 HBI  A 198 (-4.1A)
HBI  A 198 ( 3.6A)
HBI  A 198 (-4.1A)
NAP  A 191 (-3.5A)
None
None
None
HBI  A 198 ( 4.5A)
 0.65A 4kjlA-1dr6A:
21.1		 4kjlA-1dr6A:
34.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KM0_A_CP6A201_1
(DIHYDROFOLATE
REDUCTASE)		 1dr6 DIHYDROFOLATE
REDUCTASE
(Gallus
gallus) 		6 / 10 ILE A   7
ALA A   9
PHE A  34
THR A  56
TYR A 121
THR A 136
 HBI  A 198 (-4.1A)
HBI  A 198 ( 3.6A)
HBI  A 198 (-4.1A)
NAP  A 191 (-3.5A)
None
HBI  A 198 ( 4.5A)
 0.54A 4km0A-1dr6A:
19.9		 4km0A-1dr6A:
29.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KM0_B_CP6B201_1
(DIHYDROFOLATE
REDUCTASE)		 1dr6 DIHYDROFOLATE
REDUCTASE
(Gallus
gallus) 		6 / 12 ILE A   7
ALA A   9
PHE A  34
THR A  56
TYR A 121
THR A 136
 HBI  A 198 (-4.1A)
HBI  A 198 ( 3.6A)
HBI  A 198 (-4.1A)
NAP  A 191 (-3.5A)
None
HBI  A 198 ( 4.5A)
 0.51A 4km0B-1dr6A:
20.1		 4km0B-1dr6A:
29.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KM2_A_TOPA202_1
(DIHYDROFOLATE
REDUCTASE)		 1dr6 DIHYDROFOLATE
REDUCTASE
(Gallus
gallus) 		7 / 12 ILE A   7
ALA A   9
PHE A  34
THR A  56
LEU A  67
TYR A 121
THR A 136
 HBI  A 198 (-4.1A)
HBI  A 198 ( 3.6A)
HBI  A 198 (-4.1A)
NAP  A 191 (-3.5A)
None
None
HBI  A 198 ( 4.5A)
 0.53A 4km2A-1dr6A:
20.1		 4km2A-1dr6A:
29.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KM2_B_TOPB202_1
(DIHYDROFOLATE
REDUCTASE)		 1dr6 DIHYDROFOLATE
REDUCTASE
(Gallus
gallus) 		6 / 12 ILE A   7
ALA A   9
PHE A  34
LEU A  67
TYR A 121
THR A 136
 HBI  A 198 (-4.1A)
HBI  A 198 ( 3.6A)
HBI  A 198 (-4.1A)
None
None
HBI  A 198 ( 4.5A)
 0.47A 4km2B-1dr6A:
19.8		 4km2B-1dr6A:
29.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KM2_B_TOPB202_1
(DIHYDROFOLATE
REDUCTASE)		 1dr6 DIHYDROFOLATE
REDUCTASE
(Gallus
gallus) 		5 / 12 ILE A   7
PHE A  34
THR A  56
LEU A  67
TYR A 121
 HBI  A 198 (-4.1A)
HBI  A 198 (-4.1A)
NAP  A 191 (-3.5A)
None
None
 0.59A 4km2B-1dr6A:
19.8		 4km2B-1dr6A:
29.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KTT_A_SAMA405_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 1ltz PHENYLALANINE-4-HYDR
OXYLASE
(Chromobacterium
violaceum) 		4 / 8 HIS A 138
PRO A 134
ASP A 139
PHE A 116
 FE  A 400 (-3.3A)
None
HBI  A 500 ( 4.9A)
None
 0.98A 4kttA-1ltzA:
undetectable		 4kttA-1ltzA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KTT_C_SAMC404_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 1ltz PHENYLALANINE-4-HYDR
OXYLASE
(Chromobacterium
violaceum) 		4 / 8 HIS A 138
PRO A 134
ASP A 139
PHE A 116
 FE  A 400 (-3.3A)
None
HBI  A 500 ( 4.9A)
None
 0.98A 4kttC-1ltzA:
undetectable		 4kttC-1ltzA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KY8_A_MTXA603_1
(BIFUNCTIONAL
THYMIDYLATE
SYNTHASE-DIHYDROFOLA
TE REDUCTASE)		 1dr6 DIHYDROFOLATE
REDUCTASE
(Gallus
gallus) 		5 / 12 ALA A   9
LEU A  22
LYS A  32
SER A  59
THR A 136
 HBI  A 198 ( 3.6A)
NAP  A 191 ( 4.7A)
None
NAP  A 191 ( 4.1A)
HBI  A 198 ( 4.5A)
 0.85A 4ky8A-1dr6A:
16.1		 4ky8A-1dr6A:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KY8_A_MTXA603_1
(BIFUNCTIONAL
THYMIDYLATE
SYNTHASE-DIHYDROFOLA
TE REDUCTASE)		 1dr6 DIHYDROFOLATE
REDUCTASE
(Gallus
gallus) 		7 / 12 ALA A   9
LEU A  22
SER A  59
ILE A  60
LEU A  67
ARG A  70
THR A 136
 HBI  A 198 ( 3.6A)
NAP  A 191 ( 4.7A)
NAP  A 191 ( 4.1A)
None
None
None
HBI  A 198 ( 4.5A)
 0.76A 4ky8A-1dr6A:
16.1		 4ky8A-1dr6A:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KY8_B_MTXB603_1
(BIFUNCTIONAL
THYMIDYLATE
SYNTHASE-DIHYDROFOLA
TE REDUCTASE)		 1dr6 DIHYDROFOLATE
REDUCTASE
(Gallus
gallus) 		6 / 12 ALA A   9
LEU A  22
LYS A  32
SER A  59
ILE A  60
THR A 136
 HBI  A 198 ( 3.6A)
NAP  A 191 ( 4.7A)
None
NAP  A 191 ( 4.1A)
None
HBI  A 198 ( 4.5A)
 0.84A 4ky8B-1dr6A:
17.1		 4ky8B-1dr6A:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KY8_B_MTXB603_1
(BIFUNCTIONAL
THYMIDYLATE
SYNTHASE-DIHYDROFOLA
TE REDUCTASE)		 1dr6 DIHYDROFOLATE
REDUCTASE
(Gallus
gallus) 		7 / 12 ALA A   9
LEU A  22
SER A  59
ILE A  60
LEU A  67
ARG A  70
THR A 136
 HBI  A 198 ( 3.6A)
NAP  A 191 ( 4.7A)
NAP  A 191 ( 4.1A)
None
None
None
HBI  A 198 ( 4.5A)
 0.84A 4ky8B-1dr6A:
17.1		 4ky8B-1dr6A:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KY8_C_MTXC603_1
(BIFUNCTIONAL
THYMIDYLATE
SYNTHASE-DIHYDROFOLA
TE REDUCTASE)		 1dr6 DIHYDROFOLATE
REDUCTASE
(Gallus
gallus) 		6 / 12 ALA A   9
LEU A  22
ILE A  60
LEU A  67
ARG A  70
THR A 136
 HBI  A 198 ( 3.6A)
NAP  A 191 ( 4.7A)
None
None
None
HBI  A 198 ( 4.5A)
 0.72A 4ky8C-1dr6A:
23.5		 4ky8C-1dr6A:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KY8_C_MTXC603_1
(BIFUNCTIONAL
THYMIDYLATE
SYNTHASE-DIHYDROFOLA
TE REDUCTASE)		 1dr6 DIHYDROFOLATE
REDUCTASE
(Gallus
gallus) 		5 / 12 ALA A   9
LEU A  22
LYS A  32
SER A  59
THR A 136
 HBI  A 198 ( 3.6A)
NAP  A 191 ( 4.7A)
None
NAP  A 191 ( 4.1A)
HBI  A 198 ( 4.5A)
 0.89A 4ky8C-1dr6A:
23.5		 4ky8C-1dr6A:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KY8_C_MTXC603_1
(BIFUNCTIONAL
THYMIDYLATE
SYNTHASE-DIHYDROFOLA
TE REDUCTASE)		 1dr6 DIHYDROFOLATE
REDUCTASE
(Gallus
gallus) 		5 / 12 ALA A   9
LEU A  22
SER A  59
ILE A  60
THR A 136
 HBI  A 198 ( 3.6A)
NAP  A 191 ( 4.7A)
NAP  A 191 ( 4.1A)
None
HBI  A 198 ( 4.5A)
 0.78A 4ky8C-1dr6A:
23.5		 4ky8C-1dr6A:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KY8_D_MTXD603_1
(BIFUNCTIONAL
THYMIDYLATE
SYNTHASE-DIHYDROFOLA
TE REDUCTASE)		 1dr6 DIHYDROFOLATE
REDUCTASE
(Gallus
gallus) 		6 / 12 ALA A   9
LEU A  22
LYS A  32
SER A  59
ILE A  60
THR A 136
 HBI  A 198 ( 3.6A)
NAP  A 191 ( 4.7A)
None
NAP  A 191 ( 4.1A)
None
HBI  A 198 ( 4.5A)
 0.90A 4ky8D-1dr6A:
19.8		 4ky8D-1dr6A:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KY8_D_MTXD603_1
(BIFUNCTIONAL
THYMIDYLATE
SYNTHASE-DIHYDROFOLA
TE REDUCTASE)		 1dr6 DIHYDROFOLATE
REDUCTASE
(Gallus
gallus) 		7 / 12 ALA A   9
LEU A  22
SER A  59
ILE A  60
LEU A  67
ARG A  70
THR A 136
 HBI  A 198 ( 3.6A)
NAP  A 191 ( 4.7A)
NAP  A 191 ( 4.1A)
None
None
None
HBI  A 198 ( 4.5A)
 0.85A 4ky8D-1dr6A:
19.8		 4ky8D-1dr6A:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KY8_E_MTXE603_1
(BIFUNCTIONAL
THYMIDYLATE
SYNTHASE-DIHYDROFOLA
TE REDUCTASE)		 1dr6 DIHYDROFOLATE
REDUCTASE
(Gallus
gallus) 		5 / 12 ALA A   9
LEU A  22
LYS A  32
SER A  59
THR A 136
 HBI  A 198 ( 3.6A)
NAP  A 191 ( 4.7A)
None
NAP  A 191 ( 4.1A)
HBI  A 198 ( 4.5A)
 0.87A 4ky8E-1dr6A:
23.5		 4ky8E-1dr6A:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KY8_E_MTXE603_1
(BIFUNCTIONAL
THYMIDYLATE
SYNTHASE-DIHYDROFOLA
TE REDUCTASE)		 1dr6 DIHYDROFOLATE
REDUCTASE
(Gallus
gallus) 		7 / 12 ALA A   9
LEU A  22
SER A  59
ILE A  60
LEU A  67
ARG A  70
THR A 136
 HBI  A 198 ( 3.6A)
NAP  A 191 ( 4.7A)
NAP  A 191 ( 4.1A)
None
None
None
HBI  A 198 ( 4.5A)
 0.85A 4ky8E-1dr6A:
23.5		 4ky8E-1dr6A:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_A_FOLA703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1dr6 DIHYDROFOLATE
REDUCTASE
(Gallus
gallus) 		6 / 11 ALA A   9
THR A  56
LEU A  67
ARG A  70
VAL A 115
THR A 136
 HBI  A 198 ( 3.6A)
NAP  A 191 (-3.5A)
None
None
HBI  A 198 ( 4.3A)
HBI  A 198 ( 4.5A)
 0.33A 4kyaA-1dr6A:
11.4		 4kyaA-1dr6A:
17.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_B_FOLB703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1dr6 DIHYDROFOLATE
REDUCTASE
(Gallus
gallus) 		5 / 12 ALA A   9
LEU A  67
ARG A  70
VAL A 115
THR A 136
 HBI  A 198 ( 3.6A)
None
None
HBI  A 198 ( 4.3A)
HBI  A 198 ( 4.5A)
 0.42A 4kyaB-1dr6A:
23.5		 4kyaB-1dr6A:
17.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_C_FOLC703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1dr6 DIHYDROFOLATE
REDUCTASE
(Gallus
gallus) 		5 / 10 ALA A   9
LEU A  67
ARG A  70
VAL A 115
THR A 136
 HBI  A 198 ( 3.6A)
None
None
HBI  A 198 ( 4.3A)
HBI  A 198 ( 4.5A)
 0.35A 4kyaC-1dr6A:
18.3		 4kyaC-1dr6A:
17.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_D_FOLD703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1dr6 DIHYDROFOLATE
REDUCTASE
(Gallus
gallus) 		5 / 12 ALA A   9
LEU A  67
ARG A  70
VAL A 115
THR A 136
 HBI  A 198 ( 3.6A)
None
None
HBI  A 198 ( 4.3A)
HBI  A 198 ( 4.5A)
 0.47A 4kyaD-1dr6A:
15.6		 4kyaD-1dr6A:
17.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_E_FOLE703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1dr6 DIHYDROFOLATE
REDUCTASE
(Gallus
gallus) 		6 / 11 ALA A   9
THR A  56
LEU A  67
ARG A  70
VAL A 115
THR A 136
 HBI  A 198 ( 3.6A)
NAP  A 191 (-3.5A)
None
None
HBI  A 198 ( 4.3A)
HBI  A 198 ( 4.5A)
 0.35A 4kyaE-1dr6A:
24.6		 4kyaE-1dr6A:
17.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_F_FOLF703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1dr6 DIHYDROFOLATE
REDUCTASE
(Gallus
gallus) 		5 / 12 ALA A   9
LEU A  67
ARG A  70
VAL A 115
THR A 136
 HBI  A 198 ( 3.6A)
None
None
HBI  A 198 ( 4.3A)
HBI  A 198 ( 4.5A)
 0.43A 4kyaF-1dr6A:
15.6		 4kyaF-1dr6A:
17.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_G_FOLG703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1dr6 DIHYDROFOLATE
REDUCTASE
(Gallus
gallus) 		6 / 11 ALA A   9
THR A  56
LEU A  67
ARG A  70
VAL A 115
THR A 136
 HBI  A 198 ( 3.6A)
NAP  A 191 (-3.5A)
None
None
HBI  A 198 ( 4.3A)
HBI  A 198 ( 4.5A)
 0.33A 4kyaG-1dr6A:
24.7		 4kyaG-1dr6A:
17.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_H_FOLH703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1dr6 DIHYDROFOLATE
REDUCTASE
(Gallus
gallus) 		5 / 12 ALA A   9
LEU A  67
ARG A  70
VAL A 115
THR A 136
 HBI  A 198 ( 3.6A)
None
None
HBI  A 198 ( 4.3A)
HBI  A 198 ( 4.5A)
 0.44A 4kyaH-1dr6A:
22.7		 4kyaH-1dr6A:
17.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4M2X_A_TMQA202_1
(DIHYDROFOLATE
REDUCTASE)		 1dr6 DIHYDROFOLATE
REDUCTASE
(Gallus
gallus) 		5 / 12 ILE A   7
ALA A   9
PHE A  34
LEU A  67
TYR A 121
 HBI  A 198 (-4.1A)
HBI  A 198 ( 3.6A)
HBI  A 198 (-4.1A)
None
None
 0.43A 4m2xA-1dr6A:
20.6		 4m2xA-1dr6A:
30.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4M2X_A_TMQA202_1
(DIHYDROFOLATE
REDUCTASE)		 1dr6 DIHYDROFOLATE
REDUCTASE
(Gallus
gallus) 		5 / 12 ILE A   7
PHE A  34
PRO A  61
LEU A  67
TYR A 121
 HBI  A 198 (-4.1A)
HBI  A 198 (-4.1A)
None
None
None
 0.56A 4m2xA-1dr6A:
20.6		 4m2xA-1dr6A:
30.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4M2X_C_TMQC202_1
(DIHYDROFOLATE
REDUCTASE)		 1dr6 DIHYDROFOLATE
REDUCTASE
(Gallus
gallus) 		5 / 12 ILE A   7
ALA A   9
LEU A  67
TYR A 121
THR A 136
 HBI  A 198 (-4.1A)
HBI  A 198 ( 3.6A)
None
None
HBI  A 198 ( 4.5A)
 0.44A 4m2xC-1dr6A:
20.6		 4m2xC-1dr6A:
30.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4M2X_C_TMQC202_1
(DIHYDROFOLATE
REDUCTASE)		 1dr6 DIHYDROFOLATE
REDUCTASE
(Gallus
gallus) 		5 / 12 ILE A   7
ALA A   9
PRO A  61
LEU A  67
TYR A 121
 HBI  A 198 (-4.1A)
HBI  A 198 ( 3.6A)
None
None
None
 0.64A 4m2xC-1dr6A:
20.6		 4m2xC-1dr6A:
30.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4M2X_G_TMQG202_1
(DIHYDROFOLATE
REDUCTASE)		 1dr6 DIHYDROFOLATE
REDUCTASE
(Gallus
gallus) 		5 / 12 ILE A   7
ALA A   9
PRO A  61
TYR A 121
THR A 136
 HBI  A 198 (-4.1A)
HBI  A 198 ( 3.6A)
None
None
HBI  A 198 ( 4.5A)
 0.59A 4m2xG-1dr6A:
20.6		 4m2xG-1dr6A:
30.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4M6K_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1dr6 DIHYDROFOLATE
REDUCTASE
(Gallus
gallus) 		10 / 12 ILE A   7
ALA A   9
LEU A  22
PHE A  34
THR A  56
ILE A  60
PRO A  61
LEU A  67
TYR A 121
THR A 136
 HBI  A 198 (-4.1A)
HBI  A 198 ( 3.6A)
NAP  A 191 ( 4.7A)
HBI  A 198 (-4.1A)
NAP  A 191 (-3.5A)
None
None
None
None
HBI  A 198 ( 4.5A)
 0.54A 4m6kA-1dr6A:
32.1		 4m6kA-1dr6A:
74.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NDN_A_SAMA407_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 1ltz PHENYLALANINE-4-HYDR
OXYLASE
(Chromobacterium
violaceum) 		4 / 8 HIS A 138
PRO A 134
ASP A 139
PHE A 116
 FE  A 400 (-3.3A)
None
HBI  A 500 ( 4.9A)
None
 0.89A 4ndnA-1ltzA:
undetectable		 4ndnA-1ltzA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NDN_C_SAMC405_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 1ltz PHENYLALANINE-4-HYDR
OXYLASE
(Chromobacterium
violaceum) 		4 / 7 HIS A 138
PRO A 134
ASP A 139
PHE A 116
 FE  A 400 (-3.3A)
None
HBI  A 500 ( 4.9A)
None
 0.97A 4ndnC-1ltzA:
undetectable		 4ndnC-1ltzA:
22.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4NX6_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1dr6 DIHYDROFOLATE
REDUCTASE
(Gallus
gallus) 		6 / 12 ALA A   9
PHE A  34
THR A  56
ILE A  60
LEU A  67
TYR A 121
 HBI  A 198 ( 3.6A)
HBI  A 198 (-4.1A)
NAP  A 191 (-3.5A)
None
None
None
 0.68A 4nx6A-1dr6A:
21.2		 4nx6A-1dr6A:
33.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4NX7_A_FOLA202_0
(DIHYDROFOLATE
REDUCTASE)		 1dr6 DIHYDROFOLATE
REDUCTASE
(Gallus
gallus) 		6 / 12 ALA A   9
PHE A  34
THR A  56
ILE A  60
LEU A  67
TYR A 121
 HBI  A 198 ( 3.6A)
HBI  A 198 (-4.1A)
NAP  A 191 (-3.5A)
None
None
None
 0.72A 4nx7A-1dr6A:
21.1		 4nx7A-1dr6A:
33.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODJ_A_SAMA500_0
(S-ADENOSYLMETHIONINE
SYNTHASE)		 1ltz PHENYLALANINE-4-HYDR
OXYLASE
(Chromobacterium
violaceum) 		4 / 7 HIS A 138
PRO A 134
ASP A 139
PHE A 116
 FE  A 400 (-3.3A)
None
HBI  A 500 ( 4.9A)
None
 1.02A 4odjA-1ltzA:
undetectable		 4odjA-1ltzA:
21.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4P3Q_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1dr6 DIHYDROFOLATE
REDUCTASE
(Gallus
gallus) 		7 / 12 ILE A   7
ALA A   9
PHE A  34
THR A  56
ILE A  60
LEU A  67
TYR A 121
 HBI  A 198 (-4.1A)
HBI  A 198 ( 3.6A)
HBI  A 198 (-4.1A)
NAP  A 191 (-3.5A)
None
None
None
 0.61A 4p3qA-1dr6A:
21.2		 4p3qA-1dr6A:
33.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4P3R_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1dr6 DIHYDROFOLATE
REDUCTASE
(Gallus
gallus) 		7 / 12 ILE A   7
ALA A   9
PHE A  34
THR A  56
ILE A  60
LEU A  67
TYR A 121
 HBI  A 198 (-4.1A)
HBI  A 198 ( 3.6A)
HBI  A 198 (-4.1A)
NAP  A 191 (-3.5A)
None
None
None
 0.68A 4p3rA-1dr6A:
21.1		 4p3rA-1dr6A:
33.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4P66_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 1dr6 DIHYDROFOLATE
REDUCTASE
(Gallus
gallus) 		6 / 11 ILE A   7
ALA A   9
LEU A  67
ARG A  70
TYR A 121
THR A 136
 HBI  A 198 (-4.1A)
HBI  A 198 ( 3.6A)
None
None
None
HBI  A 198 ( 4.5A)
 0.35A 4p66A-1dr6A:
21.2		 4p66A-1dr6A:
33.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4P68_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 1dr6 DIHYDROFOLATE
REDUCTASE
(Gallus
gallus) 		7 / 11 ILE A   7
PHE A  34
SER A  59
ILE A  60
ARG A  70
TYR A 121
THR A 136
 HBI  A 198 (-4.1A)
HBI  A 198 (-4.1A)
NAP  A 191 ( 4.1A)
None
None
None
HBI  A 198 ( 4.5A)
 0.57A 4p68A-1dr6A:
21.0		 4p68A-1dr6A:
33.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4PAH_A_LNRA600_1
(PHENYLALANINE
HYDROXYLASE)		 1dmw PHENYLALANINE
HYDROXYLASE
(Homo
sapiens) 		6 / 6 LEU A 248
PHE A 254
HIS A 285
HIS A 290
TYR A 325
GLU A 330
 HBI  A 700 ( 4.5A)
HBI  A 700 (-3.6A)
FE  A 425 (-3.4A)
FE  A 425 (-3.3A)
HBI  A 700 (-3.8A)
FE  A 425 (-2.5A)
 0.40A 4pahA-1dmwA:
53.5		 4pahA-1dmwA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PAH_A_LNRA600_1
(PHENYLALANINE
HYDROXYLASE)		 1ltz PHENYLALANINE-4-HYDR
OXYLASE
(Chromobacterium
violaceum) 		4 / 6 LEU A 101
PHE A 107
TYR A 179
GLU A 184
 HBI  A 500 ( 4.5A)
HBI  A 500 (-3.8A)
HBI  A 500 ( 4.0A)
FE  A 400 (-1.9A)
 0.94A 4pahA-1ltzA:
28.0		 4pahA-1ltzA:
28.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PAH_A_LNRA600_1
(PHENYLALANINE
HYDROXYLASE)		 1ltz PHENYLALANINE-4-HYDR
OXYLASE
(Chromobacterium
violaceum) 		5 / 6 PHE A 107
HIS A 138
HIS A 143
TYR A 179
GLU A 184
 HBI  A 500 (-3.8A)
FE  A 400 (-3.3A)
FE  A 400 (-3.4A)
HBI  A 500 ( 4.0A)
FE  A 400 (-1.9A)
 0.55A 4pahA-1ltzA:
28.0		 4pahA-1ltzA:
28.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4PSS_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1dr6 DIHYDROFOLATE
REDUCTASE
(Gallus
gallus) 		7 / 12 ILE A   7
ALA A   9
PHE A  34
THR A  56
ILE A  60
LEU A  67
TYR A 121
 HBI  A 198 (-4.1A)
HBI  A 198 ( 3.6A)
HBI  A 198 (-4.1A)
NAP  A 191 (-3.5A)
None
None
None
 0.69A 4pssA-1dr6A:
undetectable		 4pssA-1dr6A:
33.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4PST_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1dr6 DIHYDROFOLATE
REDUCTASE
(Gallus
gallus) 		6 / 12 ALA A   9
PHE A  34
THR A  56
ILE A  60
LEU A  67
THR A 136
 HBI  A 198 ( 3.6A)
HBI  A 198 (-4.1A)
NAP  A 191 (-3.5A)
None
None
HBI  A 198 ( 4.5A)
 0.73A 4pstA-1dr6A:
undetectable		 4pstA-1dr6A:
33.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4PST_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1dr6 DIHYDROFOLATE
REDUCTASE
(Gallus
gallus) 		6 / 12 ALA A   9
PHE A  34
THR A  56
LEU A  67
TYR A 121
THR A 136
 HBI  A 198 ( 3.6A)
HBI  A 198 (-4.1A)
NAP  A 191 (-3.5A)
None
None
HBI  A 198 ( 4.5A)
 0.39A 4pstA-1dr6A:
undetectable		 4pstA-1dr6A:
33.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4PSY_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1dr6 DIHYDROFOLATE
REDUCTASE
(Gallus
gallus) 		7 / 12 ILE A   7
ALA A   9
PHE A  34
ILE A  60
LEU A  67
TYR A 121
THR A 136
 HBI  A 198 (-4.1A)
HBI  A 198 ( 3.6A)
HBI  A 198 (-4.1A)
None
None
None
HBI  A 198 ( 4.5A)
 0.72A 4psyA-1dr6A:
21.1		 4psyA-1dr6A:
33.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4PTH_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1dr6 DIHYDROFOLATE
REDUCTASE
(Gallus
gallus) 		8 / 12 ILE A   7
ALA A   9
THR A  56
ILE A  60
LEU A  67
ARG A  70
TYR A 121
THR A 136
 HBI  A 198 (-4.1A)
HBI  A 198 ( 3.6A)
NAP  A 191 (-3.5A)
None
None
None
None
HBI  A 198 ( 4.5A)
 0.65A 4pthA-1dr6A:
20.9		 4pthA-1dr6A:
33.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4PTJ_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1dr6 DIHYDROFOLATE
REDUCTASE
(Gallus
gallus) 		8 / 12 ILE A   7
ALA A   9
PHE A  34
THR A  56
ILE A  60
ARG A  70
TYR A 121
THR A 136
 HBI  A 198 (-4.1A)
HBI  A 198 ( 3.6A)
HBI  A 198 (-4.1A)
NAP  A 191 (-3.5A)
None
None
None
HBI  A 198 ( 4.5A)
 0.60A 4ptjA-1dr6A:
21.1		 4ptjA-1dr6A:
33.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0D_A_MTXA604_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1dr6 DIHYDROFOLATE
REDUCTASE
(Gallus
gallus) 		7 / 12 ALA A   9
LEU A  22
ILE A  60
LEU A  67
ARG A  70
TYR A 121
THR A 136
 HBI  A 198 ( 3.6A)
NAP  A 191 ( 4.7A)
None
None
None
None
HBI  A 198 ( 4.5A)
 0.73A 4q0dA-1dr6A:
23.4		 4q0dA-1dr6A:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0D_A_MTXA604_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1dr6 DIHYDROFOLATE
REDUCTASE
(Gallus
gallus) 		5 / 12 ALA A   9
LEU A  22
LYS A  32
TYR A 121
THR A 136
 HBI  A 198 ( 3.6A)
NAP  A 191 ( 4.7A)
None
None
HBI  A 198 ( 4.5A)
 0.73A 4q0dA-1dr6A:
23.4		 4q0dA-1dr6A:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0D_B_MTXB604_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1dr6 DIHYDROFOLATE
REDUCTASE
(Gallus
gallus) 		7 / 12 ALA A   9
LEU A  22
ILE A  60
LEU A  67
ARG A  70
TYR A 121
THR A 136
 HBI  A 198 ( 3.6A)
NAP  A 191 ( 4.7A)
None
None
None
None
HBI  A 198 ( 4.5A)
 0.73A 4q0dB-1dr6A:
23.5		 4q0dB-1dr6A:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0D_B_MTXB604_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1dr6 DIHYDROFOLATE
REDUCTASE
(Gallus
gallus) 		5 / 12 ALA A   9
LEU A  22
LYS A  32
TYR A 121
THR A 136
 HBI  A 198 ( 3.6A)
NAP  A 191 ( 4.7A)
None
None
HBI  A 198 ( 4.5A)
 0.73A 4q0dB-1dr6A:
23.5		 4q0dB-1dr6A:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0D_C_MTXC604_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1dr6 DIHYDROFOLATE
REDUCTASE
(Gallus
gallus) 		6 / 12 ALA A   9
LEU A  22
LEU A  67
ARG A  70
TYR A 121
THR A 136
 HBI  A 198 ( 3.6A)
NAP  A 191 ( 4.7A)
None
None
None
HBI  A 198 ( 4.5A)
 0.49A 4q0dC-1dr6A:
23.5		 4q0dC-1dr6A:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0D_C_MTXC604_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1dr6 DIHYDROFOLATE
REDUCTASE
(Gallus
gallus) 		6 / 12 ALA A   9
LEU A  22
LYS A  32
SER A  59
TYR A 121
THR A 136
 HBI  A 198 ( 3.6A)
NAP  A 191 ( 4.7A)
None
NAP  A 191 ( 4.1A)
None
HBI  A 198 ( 4.5A)
 0.86A 4q0dC-1dr6A:
23.5		 4q0dC-1dr6A:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0D_D_MTXD604_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1dr6 DIHYDROFOLATE
REDUCTASE
(Gallus
gallus) 		6 / 12 ALA A   9
LEU A  22
LEU A  67
ARG A  70
TYR A 121
THR A 136
 HBI  A 198 ( 3.6A)
NAP  A 191 ( 4.7A)
None
None
None
HBI  A 198 ( 4.5A)
 0.50A 4q0dD-1dr6A:
23.5		 4q0dD-1dr6A:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0D_D_MTXD604_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1dr6 DIHYDROFOLATE
REDUCTASE
(Gallus
gallus) 		6 / 12 ALA A   9
LEU A  22
LYS A  32
SER A  59
TYR A 121
THR A 136
 HBI  A 198 ( 3.6A)
NAP  A 191 ( 4.7A)
None
NAP  A 191 ( 4.1A)
None
HBI  A 198 ( 4.5A)
 0.86A 4q0dD-1dr6A:
23.5		 4q0dD-1dr6A:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0D_E_MTXE604_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1dr6 DIHYDROFOLATE
REDUCTASE
(Gallus
gallus) 		7 / 12 ALA A   9
LEU A  22
ILE A  60
LEU A  67
ARG A  70
TYR A 121
THR A 136
 HBI  A 198 ( 3.6A)
NAP  A 191 ( 4.7A)
None
None
None
None
HBI  A 198 ( 4.5A)
 0.73A 4q0dE-1dr6A:
23.5		 4q0dE-1dr6A:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0D_E_MTXE604_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1dr6 DIHYDROFOLATE
REDUCTASE
(Gallus
gallus) 		5 / 12 ALA A   9
LEU A  22
LYS A  32
TYR A 121
THR A 136
 HBI  A 198 ( 3.6A)
NAP  A 191 ( 4.7A)
None
None
HBI  A 198 ( 4.5A)
 0.73A 4q0dE-1dr6A:
23.5		 4q0dE-1dr6A:
17.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QI9_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 1dr6 DIHYDROFOLATE
REDUCTASE
(Gallus
gallus) 		7 / 12 ILE A   7
ALA A   9
ILE A  60
LEU A  67
ARG A  70
TYR A 121
THR A 136
 HBI  A 198 (-4.1A)
HBI  A 198 ( 3.6A)
None
None
None
None
HBI  A 198 ( 4.5A)
 0.70A 4qi9A-1dr6A:
18.2		 4qi9A-1dr6A:
32.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QI9_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 1dr6 DIHYDROFOLATE
REDUCTASE
(Gallus
gallus) 		6 / 12 ILE A   7
ALA A   9
SER A  59
ILE A  60
TYR A 121
THR A 136
 HBI  A 198 (-4.1A)
HBI  A 198 ( 3.6A)
NAP  A 191 ( 4.1A)
None
None
HBI  A 198 ( 4.5A)
 0.86A 4qi9A-1dr6A:
18.2		 4qi9A-1dr6A:
32.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QI9_B_MTXB201_1
(DIHYDROFOLATE
REDUCTASE)		 1dr6 DIHYDROFOLATE
REDUCTASE
(Gallus
gallus) 		7 / 12 ILE A   7
ALA A   9
ILE A  60
LEU A  67
ARG A  70
TYR A 121
THR A 136
 HBI  A 198 (-4.1A)
HBI  A 198 ( 3.6A)
None
None
None
None
HBI  A 198 ( 4.5A)
 0.66A 4qi9B-1dr6A:
18.8		 4qi9B-1dr6A:
32.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QI9_B_MTXB201_1
(DIHYDROFOLATE
REDUCTASE)		 1dr6 DIHYDROFOLATE
REDUCTASE
(Gallus
gallus) 		5 / 12 ILE A   7
ALA A   9
SER A  59
TYR A 121
THR A 136
 HBI  A 198 (-4.1A)
HBI  A 198 ( 3.6A)
NAP  A 191 ( 4.1A)
None
HBI  A 198 ( 4.5A)
 0.68A 4qi9B-1dr6A:
18.8		 4qi9B-1dr6A:
32.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QI9_C_MTXC201_1
(DIHYDROFOLATE
REDUCTASE)		 1dr6 DIHYDROFOLATE
REDUCTASE
(Gallus
gallus) 		7 / 11 ILE A   7
ALA A   9
ILE A  60
LEU A  67
ARG A  70
TYR A 121
THR A 136
 HBI  A 198 (-4.1A)
HBI  A 198 ( 3.6A)
None
None
None
None
HBI  A 198 ( 4.5A)
 0.71A 4qi9C-1dr6A:
18.0		 4qi9C-1dr6A:
32.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QI9_C_MTXC201_1
(DIHYDROFOLATE
REDUCTASE)		 1dr6 DIHYDROFOLATE
REDUCTASE
(Gallus
gallus) 		5 / 11 ILE A   7
ALA A   9
SER A  59
TYR A 121
THR A 136
 HBI  A 198 (-4.1A)
HBI  A 198 ( 3.6A)
NAP  A 191 ( 4.1A)
None
HBI  A 198 ( 4.5A)
 0.70A 4qi9C-1dr6A:
18.0		 4qi9C-1dr6A:
32.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QLE_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1dr6 DIHYDROFOLATE
REDUCTASE
(Gallus
gallus) 		8 / 12 ILE A   7
ALA A   9
PHE A  34
THR A  56
ILE A  60
LEU A  67
TYR A 121
THR A 136
 HBI  A 198 (-4.1A)
HBI  A 198 ( 3.6A)
HBI  A 198 (-4.1A)
NAP  A 191 (-3.5A)
None
None
None
HBI  A 198 ( 4.5A)
 0.65A 4qleA-1dr6A:
20.3		 4qleA-1dr6A:
33.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QLE_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 1dr6 DIHYDROFOLATE
REDUCTASE
(Gallus
gallus) 		7 / 11 ILE A   7
ALA A   9
ILE A  60
LEU A  67
ARG A  70
TYR A 121
THR A 136
 HBI  A 198 (-4.1A)
HBI  A 198 ( 3.6A)
None
None
None
None
HBI  A 198 ( 4.5A)
 0.68A 4qleB-1dr6A:
20.3		 4qleB-1dr6A:
33.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QLE_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 1dr6 DIHYDROFOLATE
REDUCTASE
(Gallus
gallus) 		6 / 11 ILE A   7
ALA A   9
SER A  59
ILE A  60
TYR A 121
THR A 136
 HBI  A 198 (-4.1A)
HBI  A 198 ( 3.6A)
NAP  A 191 ( 4.1A)
None
None
HBI  A 198 ( 4.5A)
 0.92A 4qleB-1dr6A:
20.3		 4qleB-1dr6A:
33.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QLF_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1dr6 DIHYDROFOLATE
REDUCTASE
(Gallus
gallus) 		8 / 11 ILE A   7
ALA A   9
PHE A  34
ILE A  60
LEU A  67
ARG A  70
TYR A 121
THR A 136
 HBI  A 198 (-4.1A)
HBI  A 198 ( 3.6A)
HBI  A 198 (-4.1A)
None
None
None
None
HBI  A 198 ( 4.5A)
 0.67A 4qlfA-1dr6A:
17.4		 4qlfA-1dr6A:
33.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QLG_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1dr6 DIHYDROFOLATE
REDUCTASE
(Gallus
gallus) 		8 / 12 ILE A   7
ALA A   9
PHE A  34
ILE A  60
LEU A  67
ARG A  70
TYR A 121
THR A 136
 HBI  A 198 (-4.1A)
HBI  A 198 ( 3.6A)
HBI  A 198 (-4.1A)
None
None
None
None
HBI  A 198 ( 4.5A)
 0.63A 4qlgA-1dr6A:
20.5		 4qlgA-1dr6A:
33.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QLG_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 1dr6 DIHYDROFOLATE
REDUCTASE
(Gallus
gallus) 		9 / 12 ILE A   7
ALA A   9
PHE A  34
THR A  56
ILE A  60
LEU A  67
ARG A  70
TYR A 121
THR A 136
 HBI  A 198 (-4.1A)
HBI  A 198 ( 3.6A)
HBI  A 198 (-4.1A)
NAP  A 191 (-3.5A)
None
None
None
None
HBI  A 198 ( 4.5A)
 0.60A 4qlgB-1dr6A:
20.1		 4qlgB-1dr6A:
33.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RGC_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1dr6 DIHYDROFOLATE
REDUCTASE
(Gallus
gallus) 		8 / 12 ILE A   7
ALA A   9
PHE A  34
ILE A  60
LEU A  67
ARG A  70
TYR A 121
THR A 136
 HBI  A 198 (-4.1A)
HBI  A 198 ( 3.6A)
HBI  A 198 (-4.1A)
None
None
None
None
HBI  A 198 ( 4.5A)
 0.66A 4rgcA-1dr6A:
21.2		 4rgcA-1dr6A:
33.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RYA_A_MTLA501_1
(ABC TRANSPORTER
SUBSTRATE BINDING
PROTEIN (SORBITOL))		 2toh TYROSINE
3-MONOOXYGENASE
(Rattus
norvegicus) 		3 / 3 GLU A 332
TYR A 371
GLU A 376
 HBI  A 500 (-3.2A)
MTY  A 300 (-3.9A)
FE  A 501 (-2.1A)
 0.82A 4ryaA-2tohA:
undetectable		 4ryaA-2tohA:
23.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UDA_A_DEXA1985_2
(MINERALOCORTICOID
RECEPTOR)		 1dmw PHENYLALANINE
HYDROXYLASE
(Homo
sapiens) 		4 / 6 LEU A 128
LEU A 255
PHE A 254
VAL A 245
 None
HBI  A 700 (-4.7A)
HBI  A 700 (-3.6A)
None
 0.97A 4udaA-1dmwA:
undetectable		 4udaA-1dmwA:
23.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4X5F_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1dr6 DIHYDROFOLATE
REDUCTASE
(Gallus
gallus) 		9 / 12 ILE A   7
ALA A   9
PHE A  34
THR A  56
ILE A  60
LEU A  67
ARG A  70
TYR A 121
THR A 136
 HBI  A 198 (-4.1A)
HBI  A 198 ( 3.6A)
HBI  A 198 (-4.1A)
NAP  A 191 (-3.5A)
None
None
None
None
HBI  A 198 ( 4.5A)
 0.57A 4x5fA-1dr6A:
20.1		 4x5fA-1dr6A:
32.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4X5F_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 1dr6 DIHYDROFOLATE
REDUCTASE
(Gallus
gallus) 		9 / 12 ILE A   7
ALA A   9
PHE A  34
THR A  56
ILE A  60
LEU A  67
ARG A  70
TYR A 121
THR A 136
 HBI  A 198 (-4.1A)
HBI  A 198 ( 3.6A)
HBI  A 198 (-4.1A)
NAP  A 191 (-3.5A)
None
None
None
None
HBI  A 198 ( 4.5A)
 0.56A 4x5fB-1dr6A:
20.4		 4x5fB-1dr6A:
32.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4X5G_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1dr6 DIHYDROFOLATE
REDUCTASE
(Gallus
gallus) 		8 / 12 ILE A   7
ALA A   9
PHE A  34
THR A  56
ILE A  60
LEU A  67
TYR A 121
THR A 136
 HBI  A 198 (-4.1A)
HBI  A 198 ( 3.6A)
HBI  A 198 (-4.1A)
NAP  A 191 (-3.5A)
None
None
None
HBI  A 198 ( 4.5A)
 0.62A 4x5gA-1dr6A:
20.1		 4x5gA-1dr6A:
32.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4X5G_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 1dr6 DIHYDROFOLATE
REDUCTASE
(Gallus
gallus) 		8 / 12 ILE A   7
ALA A   9
THR A  56
ILE A  60
LEU A  67
ARG A  70
TYR A 121
THR A 136
 HBI  A 198 (-4.1A)
HBI  A 198 ( 3.6A)
NAP  A 191 (-3.5A)
None
None
None
None
HBI  A 198 ( 4.5A)
 0.59A 4x5gB-1dr6A:
20.4		 4x5gB-1dr6A:
32.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4X5H_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1dr6 DIHYDROFOLATE
REDUCTASE
(Gallus
gallus) 		8 / 12 ILE A   7
ALA A   9
PHE A  34
THR A  56
ILE A  60
LEU A  67
TYR A 121
THR A 136
 HBI  A 198 (-4.1A)
HBI  A 198 ( 3.6A)
HBI  A 198 (-4.1A)
NAP  A 191 (-3.5A)
None
None
None
HBI  A 198 ( 4.5A)
 0.62A 4x5hA-1dr6A:
20.0		 4x5hA-1dr6A:
32.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4X5I_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1dr6 DIHYDROFOLATE
REDUCTASE
(Gallus
gallus) 		8 / 12 ILE A   7
ALA A   9
PHE A  34
THR A  56
ILE A  60
LEU A  67
TYR A 121
THR A 136
 HBI  A 198 (-4.1A)
HBI  A 198 ( 3.6A)
HBI  A 198 (-4.1A)
NAP  A 191 (-3.5A)
None
None
None
HBI  A 198 ( 4.5A)
 0.64A 4x5iA-1dr6A:
19.9		 4x5iA-1dr6A:
32.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4X5J_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1dr6 DIHYDROFOLATE
REDUCTASE
(Gallus
gallus) 		7 / 12 ILE A   7
ALA A   9
PHE A  34
THR A  56
ILE A  60
TYR A 121
THR A 136
 HBI  A 198 (-4.1A)
HBI  A 198 ( 3.6A)
HBI  A 198 (-4.1A)
NAP  A 191 (-3.5A)
None
None
HBI  A 198 ( 4.5A)
 0.61A 4x5jA-1dr6A:
19.9		 4x5jA-1dr6A:
32.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A1I_A_ADNA407_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 1ltz PHENYLALANINE-4-HYDR
OXYLASE
(Chromobacterium
violaceum) 		4 / 8 HIS A 138
PRO A 134
ASP A 139
PHE A 116
 FE  A 400 (-3.3A)
None
HBI  A 500 ( 4.9A)
None
 0.97A 5a1iA-1ltzA:
undetectable		 5a1iA-1ltzA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A1I_A_SAMA405_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 1ltz PHENYLALANINE-4-HYDR
OXYLASE
(Chromobacterium
violaceum) 		4 / 7 HIS A 138
PRO A 134
ASP A 139
PHE A 116
 FE  A 400 (-3.3A)
None
HBI  A 500 ( 4.9A)
None
 0.97A 5a1iA-1ltzA:
undetectable		 5a1iA-1ltzA:
22.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5E8Q_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1dr6 DIHYDROFOLATE
REDUCTASE
(Gallus
gallus) 		7 / 12 ILE A   7
ALA A   9
PHE A  34
THR A  56
ILE A  60
TYR A 121
THR A 136
 HBI  A 198 (-4.1A)
HBI  A 198 ( 3.6A)
HBI  A 198 (-4.1A)
NAP  A 191 (-3.5A)
None
None
HBI  A 198 ( 4.5A)
 0.67A 5e8qA-1dr6A:
19.8		 5e8qA-1dr6A:
33.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5E8Q_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 1dr6 DIHYDROFOLATE
REDUCTASE
(Gallus
gallus) 		7 / 12 ILE A   7
ALA A   9
PHE A  34
THR A  56
ILE A  60
LEU A  67
TYR A 121
 HBI  A 198 (-4.1A)
HBI  A 198 ( 3.6A)
HBI  A 198 (-4.1A)
NAP  A 191 (-3.5A)
None
None
None
 0.63A 5e8qB-1dr6A:
20.1		 5e8qB-1dr6A:
33.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5E8Q_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 1dr6 DIHYDROFOLATE
REDUCTASE
(Gallus
gallus) 		7 / 12 ILE A   7
ALA A   9
PHE A  34
THR A  56
LEU A  67
TYR A 121
THR A 136
 HBI  A 198 (-4.1A)
HBI  A 198 ( 3.6A)
HBI  A 198 (-4.1A)
NAP  A 191 (-3.5A)
None
None
HBI  A 198 ( 4.5A)
 0.46A 5e8qB-1dr6A:
20.1		 5e8qB-1dr6A:
33.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EAJ_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1dr6 DIHYDROFOLATE
REDUCTASE
(Gallus
gallus) 		8 / 12 ILE A   7
ALA A   9
PHE A  34
THR A  56
ILE A  60
LEU A  67
TYR A 121
THR A 136
 HBI  A 198 (-4.1A)
HBI  A 198 ( 3.6A)
HBI  A 198 (-4.1A)
NAP  A 191 (-3.5A)
None
None
None
HBI  A 198 ( 4.5A)
 0.66A 5eajA-1dr6A:
19.9		 5eajA-1dr6A:
33.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EAJ_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 1dr6 DIHYDROFOLATE
REDUCTASE
(Gallus
gallus) 		8 / 12 ILE A   7
ALA A   9
PHE A  34
THR A  56
ILE A  60
LEU A  67
TYR A 121
THR A 136
 HBI  A 198 (-4.1A)
HBI  A 198 ( 3.6A)
HBI  A 198 (-4.1A)
NAP  A 191 (-3.5A)
None
None
None
HBI  A 198 ( 4.5A)
 0.68A 5eajB-1dr6A:
20.3		 5eajB-1dr6A:
33.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HI6_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 1dr6 DIHYDROFOLATE
REDUCTASE
(Gallus
gallus) 		7 / 12 ILE A   7
ALA A   9
ILE A  60
LEU A  67
ARG A  70
TYR A 121
THR A 136
 HBI  A 198 (-4.1A)
HBI  A 198 ( 3.6A)
None
None
None
None
HBI  A 198 ( 4.5A)
 0.70A 5hi6A-1dr6A:
20.1		 5hi6A-1dr6A:
32.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HI6_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 1dr6 DIHYDROFOLATE
REDUCTASE
(Gallus
gallus) 		6 / 12 ILE A   7
ALA A   9
SER A  59
ILE A  60
TYR A 121
THR A 136
 HBI  A 198 (-4.1A)
HBI  A 198 ( 3.6A)
NAP  A 191 ( 4.1A)
None
None
HBI  A 198 ( 4.5A)
 0.88A 5hi6A-1dr6A:
20.1		 5hi6A-1dr6A:
32.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HI6_B_MTXB201_1
(DIHYDROFOLATE
REDUCTASE)		 1dr6 DIHYDROFOLATE
REDUCTASE
(Gallus
gallus) 		7 / 12 ILE A   7
ALA A   9
SER A  59
ILE A  60
LEU A  67
ARG A  70
TYR A 121
 HBI  A 198 (-4.1A)
HBI  A 198 ( 3.6A)
NAP  A 191 ( 4.1A)
None
None
None
None
 0.89A 5hi6B-1dr6A:
20.1		 5hi6B-1dr6A:
32.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HI6_B_MTXB201_1
(DIHYDROFOLATE
REDUCTASE)		 1dr6 DIHYDROFOLATE
REDUCTASE
(Gallus
gallus) 		7 / 12 ILE A   7
ALA A   9
SER A  59
LEU A  67
ARG A  70
TYR A 121
THR A 136
 HBI  A 198 (-4.1A)
HBI  A 198 ( 3.6A)
NAP  A 191 ( 4.1A)
None
None
None
HBI  A 198 ( 4.5A)
 0.81A 5hi6B-1dr6A:
20.1		 5hi6B-1dr6A:
32.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5C_B_TA1B502_1
(TUBULIN BETA-2B
CHAIN)		 2toh TYROSINE
3-MONOOXYGENASE
(Rattus
norvegicus) 		5 / 12 ASP A 361
LEU A 295
SER A 368
GLY A 358
LEU A 357
 None
HBI  A 500 (-4.2A)
HBI  A 500 ( 4.1A)
None
None
 1.17A 5m5cB-2tohA:
undetectable		 5m5cB-2tohA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5C_E_TA1E502_1
(TUBULIN BETA-2B
CHAIN)		 2toh TYROSINE
3-MONOOXYGENASE
(Rattus
norvegicus) 		5 / 10 ASP A 361
LEU A 295
SER A 368
GLY A 358
LEU A 357
 None
HBI  A 500 (-4.2A)
HBI  A 500 ( 4.1A)
None
None
 1.11A 5m5cE-2tohA:
undetectable		 5m5cE-2tohA:
21.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5PAH_A_LDPA600_1
(PHENYLALANINE
4-MONOOXYGENASE)		 1dmw PHENYLALANINE
HYDROXYLASE
(Homo
sapiens) 		4 / 4 HIS A 285
HIS A 290
TYR A 325
GLU A 330
 FE  A 425 (-3.4A)
FE  A 425 (-3.3A)
HBI  A 700 (-3.8A)
FE  A 425 (-2.5A)
 0.13A 5pahA-1dmwA:
53.1		 5pahA-1dmwA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5PAH_A_LDPA600_1
(PHENYLALANINE
4-MONOOXYGENASE)		 1ltz PHENYLALANINE-4-HYDR
OXYLASE
(Chromobacterium
violaceum) 		4 / 4 HIS A 138
HIS A 143
TYR A 179
GLU A 184
 FE  A 400 (-3.3A)
FE  A 400 (-3.4A)
HBI  A 500 ( 4.0A)
FE  A 400 (-1.9A)
 0.48A 5pahA-1ltzA:
28.0		 5pahA-1ltzA:
28.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T8S_B_SAMB402_1
(S-ADENOSYLMETHIONINE
SYNTHASE)		 1ltz PHENYLALANINE-4-HYDR
OXYLASE
(Chromobacterium
violaceum) 		4 / 8 HIS A 138
PRO A 134
ASP A 139
PHE A 116
 FE  A 400 (-3.3A)
None
HBI  A 500 ( 4.9A)
None
 1.05A 5t8sB-1ltzA:
undetectable		 5t8sB-1ltzA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UIH_A_8CVA201_1
(DIHYDROFOLATE
REDUCTASE)		 1dr6 DIHYDROFOLATE
REDUCTASE
(Gallus
gallus) 		4 / 8 ILE A   7
ALA A   9
TYR A 121
THR A 136
 HBI  A 198 (-4.1A)
HBI  A 198 ( 3.6A)
None
HBI  A 198 ( 4.5A)
 0.26A 5uihA-1dr6A:
19.2		 5uihA-1dr6A:
20.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5UJX_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1dr6 DIHYDROFOLATE
REDUCTASE
(Gallus
gallus) 		8 / 12 ILE A   7
ALA A   9
PHE A  34
THR A  56
ILE A  60
LEU A  67
TYR A 121
THR A 136
 HBI  A 198 (-4.1A)
HBI  A 198 ( 3.6A)
HBI  A 198 (-4.1A)
NAP  A 191 (-3.5A)
None
None
None
HBI  A 198 ( 4.5A)
 0.68A 5ujxA-1dr6A:
19.8		 5ujxA-1dr6A:
33.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5UJX_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 1dr6 DIHYDROFOLATE
REDUCTASE
(Gallus
gallus) 		8 / 12 ILE A   7
ALA A   9
PHE A  34
THR A  56
ILE A  60
LEU A  67
ARG A  70
TYR A 121
 HBI  A 198 (-4.1A)
HBI  A 198 ( 3.6A)
HBI  A 198 (-4.1A)
NAP  A 191 (-3.5A)
None
None
None
None
 0.64A 5ujxB-1dr6A:
20.1		 5ujxB-1dr6A:
33.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5UJX_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 1dr6 DIHYDROFOLATE
REDUCTASE
(Gallus
gallus) 		8 / 12 ILE A   7
ALA A   9
PHE A  34
THR A  56
LEU A  67
ARG A  70
TYR A 121
THR A 136
 HBI  A 198 (-4.1A)
HBI  A 198 ( 3.6A)
HBI  A 198 (-4.1A)
NAP  A 191 (-3.5A)
None
None
None
HBI  A 198 ( 4.5A)
 0.46A 5ujxB-1dr6A:
20.1		 5ujxB-1dr6A:
33.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5Z6F_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1dr6 DIHYDROFOLATE
REDUCTASE
(Gallus
gallus) 		8 / 12 ILE A   7
ALA A   9
PHE A  34
THR A  56
ILE A  60
ARG A  70
TYR A 121
THR A 136
 HBI  A 198 (-4.1A)
HBI  A 198 ( 3.6A)
HBI  A 198 (-4.1A)
NAP  A 191 (-3.5A)
None
None
None
HBI  A 198 ( 4.5A)
 0.66A 5z6fA-1dr6A:
21.2		 5z6fA-1dr6A:
32.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5Z6J_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1dr6 DIHYDROFOLATE
REDUCTASE
(Gallus
gallus) 		8 / 12 ILE A   7
ALA A   9
PHE A  34
THR A  56
ILE A  60
LEU A  67
TYR A 121
THR A 136
 HBI  A 198 (-4.1A)
HBI  A 198 ( 3.6A)
HBI  A 198 (-4.1A)
NAP  A 191 (-3.5A)
None
None
None
HBI  A 198 ( 4.5A)
 0.65A 5z6jA-1dr6A:
21.3		 5z6jA-1dr6A:
32.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5Z6K_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1dr6 DIHYDROFOLATE
REDUCTASE
(Gallus
gallus) 		7 / 12 ILE A   7
ALA A   9
PHE A  34
THR A  56
ILE A  60
LEU A  67
THR A 136
 HBI  A 198 (-4.1A)
HBI  A 198 ( 3.6A)
HBI  A 198 (-4.1A)
NAP  A 191 (-3.5A)
None
None
HBI  A 198 ( 4.5A)
 0.70A 5z6kA-1dr6A:
21.3		 5z6kA-1dr6A:
32.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5Z6K_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1dr6 DIHYDROFOLATE
REDUCTASE
(Gallus
gallus) 		7 / 12 ILE A   7
ALA A   9
PHE A  34
THR A  56
LEU A  67
TYR A 121
THR A 136
 HBI  A 198 (-4.1A)
HBI  A 198 ( 3.6A)
HBI  A 198 (-4.1A)
NAP  A 191 (-3.5A)
None
None
HBI  A 198 ( 4.5A)
 0.36A 5z6kA-1dr6A:
21.3		 5z6kA-1dr6A:
32.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5Z6M_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1dr6 DIHYDROFOLATE
REDUCTASE
(Gallus
gallus) 		6 / 11 ILE A   7
ALA A   9
PHE A  34
LEU A  67
TYR A 121
THR A 136
 HBI  A 198 (-4.1A)
HBI  A 198 ( 3.6A)
HBI  A 198 (-4.1A)
None
None
HBI  A 198 ( 4.5A)
 0.50A 5z6mA-1dr6A:
20.4		 5z6mA-1dr6A:
32.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6AOG_A_CP6A704_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1dr6 DIHYDROFOLATE
REDUCTASE
(Gallus
gallus) 		6 / 10 ALA A   9
PHE A  34
THR A  56
VAL A 115
TYR A 121
THR A 136
 HBI  A 198 ( 3.6A)
HBI  A 198 (-4.1A)
NAP  A 191 (-3.5A)
HBI  A 198 ( 4.3A)
None
HBI  A 198 ( 4.5A)
 0.37A 6aogA-1dr6A:
24.8		 6aogA-1dr6A:
40.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6AOG_B_CP6B704_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1dr6 DIHYDROFOLATE
REDUCTASE
(Gallus
gallus) 		6 / 10 ALA A   9
PHE A  34
THR A  56
VAL A 115
TYR A 121
THR A 136
 HBI  A 198 ( 3.6A)
HBI  A 198 (-4.1A)
NAP  A 191 (-3.5A)
HBI  A 198 ( 4.3A)
None
HBI  A 198 ( 4.5A)
 0.45A 6aogB-1dr6A:
24.4		 6aogB-1dr6A:
40.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B0I_B_TA1B502_1
(TUBULIN BETA CHAIN)		 2toh TYROSINE
3-MONOOXYGENASE
(Rattus
norvegicus) 		5 / 12 ASP A 361
LEU A 295
SER A 368
GLY A 358
LEU A 357
 None
HBI  A 500 (-4.2A)
HBI  A 500 ( 4.1A)
None
None
 1.04A 6b0iB-2tohA:
undetectable		 6b0iB-2tohA:
11.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CLX_A_SAMA401_0
(O-METHYLTRANSFERASE)		 1ltz PHENYLALANINE-4-HYDR
OXYLASE
(Chromobacterium
violaceum) 		5 / 12 ASP A 139
ARG A 123
GLY A 200
GLY A 142
PHE A 185
 HBI  A 500 ( 4.9A)
None
None
None
None
 1.31A 6clxA-1ltzA:
undetectable		 6clxA-1ltzA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E43_C_BEZC502_0
(INDOLEAMINE
2,3-DIOXYGENASE 1)		 1dmw PHENYLALANINE
HYDROXYLASE
(Homo
sapiens) 		4 / 6 PHE A 240
VAL A 329
LEU A 255
LEU A 258
 None
None
HBI  A 700 (-4.7A)
None
 0.98A 6e43C-1dmwA:
0.0		 6e43C-1dmwA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FBN_B_SAMB401_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 1ltz PHENYLALANINE-4-HYDR
OXYLASE
(Chromobacterium
violaceum) 		4 / 8 HIS A 138
PRO A 134
ASP A 139
PHE A 116
 FE  A 400 (-3.3A)
None
HBI  A 500 ( 4.9A)
None
 1.03A 6fbnB-1ltzA:
undetectable		 6fbnB-1ltzA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FBO_A_ADNA406_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 1ltz PHENYLALANINE-4-HYDR
OXYLASE
(Chromobacterium
violaceum) 		4 / 8 HIS A 138
PRO A 134
ASP A 139
PHE A 116
 FE  A 400 (-3.3A)
None
HBI  A 500 ( 4.9A)
None
 0.98A 6fboA-1ltzA:
undetectable		 6fboA-1ltzA:
14.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FCB_A_SAMA405_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 1ltz PHENYLALANINE-4-HYDR
OXYLASE
(Chromobacterium
violaceum) 		4 / 8 HIS A 138
PRO A 134
ASP A 139
PHE A 116
 FE  A 400 (-3.3A)
None
HBI  A 500 ( 4.9A)
None
 0.95A 6fcbA-1ltzA:
undetectable		 6fcbA-1ltzA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FCD_A_ADNA405_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 1ltz PHENYLALANINE-4-HYDR
OXYLASE
(Chromobacterium
violaceum) 		4 / 8 HIS A 138
PRO A 134
ASP A 139
PHE A 116
 FE  A 400 (-3.3A)
None
HBI  A 500 ( 4.9A)
None
 0.99A 6fcdA-1ltzA:
undetectable		 6fcdA-1ltzA:
14.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G6R_A_SAMA406_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 1ltz PHENYLALANINE-4-HYDR
OXYLASE
(Chromobacterium
violaceum) 		4 / 7 HIS A 138
PRO A 134
ASP A 139
PHE A 116
 FE  A 400 (-3.3A)
None
HBI  A 500 ( 4.9A)
None
 0.96A 6g6rA-1ltzA:
undetectable		 6g6rA-1ltzA:
22.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6PAH_A_DAHA600_1
(PHENYLALANINE
4-MONOOXYGENASE)		 1dmw PHENYLALANINE
HYDROXYLASE
(Homo
sapiens) 		6 / 6 LEU A 248
PRO A 281
HIS A 285
HIS A 290
TYR A 325
GLU A 330
 HBI  A 700 ( 4.5A)
None
FE  A 425 (-3.4A)
FE  A 425 (-3.3A)
HBI  A 700 (-3.8A)
FE  A 425 (-2.5A)
 0.51A 6pahA-1dmwA:
53.1		 6pahA-1dmwA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6PAH_A_DAHA600_1
(PHENYLALANINE
4-MONOOXYGENASE)		 1ltz PHENYLALANINE-4-HYDR
OXYLASE
(Chromobacterium
violaceum) 		4 / 6 LEU A 101
HIS A 138
HIS A 143
TYR A 179
 HBI  A 500 ( 4.5A)
FE  A 400 (-3.3A)
FE  A 400 (-3.4A)
HBI  A 500 ( 4.0A)
 0.80A 6pahA-1ltzA:
27.9		 6pahA-1ltzA:
28.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6PAH_A_DAHA600_1
(PHENYLALANINE
4-MONOOXYGENASE)		 1ltz PHENYLALANINE-4-HYDR
OXYLASE
(Chromobacterium
violaceum) 		5 / 6 PRO A 134
HIS A 138
HIS A 143
TYR A 179
GLU A 184
 None
FE  A 400 (-3.3A)
FE  A 400 (-3.4A)
HBI  A 500 ( 4.0A)
FE  A 400 (-1.9A)
 0.51A 6pahA-1ltzA:
27.9		 6pahA-1ltzA:
28.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6PAH_A_DAHA600_1
(PHENYLALANINE
4-MONOOXYGENASE)		 2toh TYROSINE
3-MONOOXYGENASE
(Rattus
norvegicus) 		5 / 6 LEU A 294
PRO A 327
HIS A 331
HIS A 336
TYR A 371
 HBI  A 500 (-4.7A)
HBI  A 500 (-4.1A)
FE  A 501 ( 3.3A)
FE  A 501 ( 3.4A)
MTY  A 300 (-3.9A)
 0.74A 6pahA-2tohA:
47.8		 6pahA-2tohA:
62.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6PAH_A_DAHA600_1
(PHENYLALANINE
4-MONOOXYGENASE)		 2toh TYROSINE
3-MONOOXYGENASE
(Rattus
norvegicus) 		5 / 6 PRO A 327
HIS A 331
HIS A 336
TYR A 371
GLU A 376
 HBI  A 500 (-4.1A)
FE  A 501 ( 3.3A)
FE  A 501 ( 3.4A)
MTY  A 300 (-3.9A)
FE  A 501 (-2.1A)
 0.47A 6pahA-2tohA:
47.8		 6pahA-2tohA:
62.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
7DFR_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 1dr6 DIHYDROFOLATE
REDUCTASE
(Gallus
gallus) 		8 / 12 ILE A   7
ALA A   9
PHE A  34
THR A  56
ILE A  60
LEU A  67
TYR A 121
THR A 136
 HBI  A 198 (-4.1A)
HBI  A 198 ( 3.6A)
HBI  A 198 (-4.1A)
NAP  A 191 (-3.5A)
None
None
None
HBI  A 198 ( 4.5A)
 0.69A 7dfrA-1dr6A:
21.1		 7dfrA-1dr6A:
33.69