SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'HAS'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJO_A_CUA701_0
(PHENYLETHYLAMINE
OXIDASE)		 1ehk BA3-TYPE
CYTOCHROME-C OXIDASE
(Thermus
thermophilus) 		3 / 3 HIS A 282
HIS A 283
HIS A 233
 HAS  A 801 ( 3.3A)
CU  A 803 ( 3.2A)
CU  A 803 (-3.1A)
 0.59A 1rjoA-1ehkA:
undetectable		 1rjoA-1ehkA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RKY_A_CUA801_0
(LYSYL OXIDASE)		 1ehk BA3-TYPE
CYTOCHROME-C OXIDASE
(Thermus
thermophilus) 		3 / 3 HIS A 282
HIS A 283
HIS A 233
 HAS  A 801 ( 3.3A)
CU  A 803 ( 3.2A)
CU  A 803 (-3.1A)
 0.61A 1rkyA-1ehkA:
undetectable		 1rkyA-1ehkA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TDN_A_LEUA487_0
(L-AMINO ACID OXIDASE)		 2yev CYTOCHROME C OXIDASE
POLYPEPTIDE I+III
(Thermus
thermophilus) 		4 / 7 ARG A 447
HIS A 387
PHE A 386
ILE A  49
 HAS  A1016 ( 3.1A)
HAS  A1015 (-3.2A)
HAS  A1016 ( 4.1A)
HAS  A1015 (-4.1A)
 1.33A 1tdnA-2yevA:
undetectable		 1tdnA-2yevA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UOB_A_PNNA1311_1
(DEACETOXYCEPHALOSPOR
IN C SYNTHETASE)		 2yev CYTOCHROME C OXIDASE
POLYPEPTIDE I+III
(Thermus
thermophilus) 		3 / 3 ARG A 448
ARG A 447
ILE A  49
 HAS  A1015 (-3.9A)
HAS  A1016 ( 3.1A)
HAS  A1015 (-4.1A)
 0.78A 1uobA-2yevA:
undetectable		 1uobA-2yevA:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V54_A_CUA517_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I)		 1ehk BA3-TYPE
CYTOCHROME-C OXIDASE
(Thermus
thermophilus) 		3 / 3 HIS A 233
HIS A 282
HIS A 283
 CU  A 803 (-3.1A)
HAS  A 801 ( 3.3A)
CU  A 803 ( 3.2A)
 0.17A 1v54A-1ehkA:
35.8		 1v54A-1ehkA:
28.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V54_N_CUN517_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I)		 1ehk BA3-TYPE
CYTOCHROME-C OXIDASE
(Thermus
thermophilus) 		3 / 3 HIS A 233
HIS A 282
HIS A 283
 CU  A 803 (-3.1A)
HAS  A 801 ( 3.3A)
CU  A 803 ( 3.2A)
 0.22A 1v54N-1ehkA:
35.7		 1v54N-1ehkA:
28.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V55_A_CUA517_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I)		 1ehk BA3-TYPE
CYTOCHROME-C OXIDASE
(Thermus
thermophilus) 		3 / 3 HIS A 233
HIS A 282
HIS A 283
 CU  A 803 (-3.1A)
HAS  A 801 ( 3.3A)
CU  A 803 ( 3.2A)
 0.20A 1v55A-1ehkA:
35.7		 1v55A-1ehkA:
28.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V55_N_CUN517_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I)		 1ehk BA3-TYPE
CYTOCHROME-C OXIDASE
(Thermus
thermophilus) 		3 / 3 HIS A 233
HIS A 282
HIS A 283
 CU  A 803 (-3.1A)
HAS  A 801 ( 3.3A)
CU  A 803 ( 3.2A)
 0.22A 1v55N-1ehkA:
35.8		 1v55N-1ehkA:
28.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W2Z_A_CUA701_0
(AMINE OXIDASE,
COPPER CONTAINING)		 1ehk BA3-TYPE
CYTOCHROME-C OXIDASE
(Thermus
thermophilus) 		3 / 3 HIS A 282
HIS A 283
HIS A 233
 HAS  A 801 ( 3.3A)
CU  A 803 ( 3.2A)
CU  A 803 (-3.1A)
 0.66A 1w2zA-1ehkA:
undetectable		 1w2zA-1ehkA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W2Z_B_CUB701_0
(AMINE OXIDASE,
COPPER CONTAINING)		 1ehk BA3-TYPE
CYTOCHROME-C OXIDASE
(Thermus
thermophilus) 		3 / 3 HIS A 282
HIS A 283
HIS A 233
 HAS  A 801 ( 3.3A)
CU  A 803 ( 3.2A)
CU  A 803 (-3.1A)
 0.65A 1w2zB-1ehkA:
undetectable		 1w2zB-1ehkA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W2Z_C_CUC701_0
(AMINE OXIDASE,
COPPER CONTAINING)		 1ehk BA3-TYPE
CYTOCHROME-C OXIDASE
(Thermus
thermophilus) 		3 / 3 HIS A 282
HIS A 283
HIS A 233
 HAS  A 801 ( 3.3A)
CU  A 803 ( 3.2A)
CU  A 803 (-3.1A)
 0.62A 1w2zC-1ehkA:
undetectable		 1w2zC-1ehkA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W2Z_D_CUD701_0
(AMINE OXIDASE,
COPPER CONTAINING)		 1ehk BA3-TYPE
CYTOCHROME-C OXIDASE
(Thermus
thermophilus) 		3 / 3 HIS A 282
HIS A 283
HIS A 233
 HAS  A 801 ( 3.3A)
CU  A 803 ( 3.2A)
CU  A 803 (-3.1A)
 0.63A 1w2zD-1ehkA:
undetectable		 1w2zD-1ehkA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYR_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 1ehk BA3-TYPE
CYTOCHROME-C OXIDASE
(Thermus
thermophilus) 		3 / 3 HIS A 233
HIS A 282
HIS A 283
 CU  A 803 (-3.1A)
HAS  A 801 ( 3.3A)
CU  A 803 ( 3.2A)
 0.14A 2dyrA-1ehkA:
35.8		 2dyrA-1ehkA:
28.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYR_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 1ehk BA3-TYPE
CYTOCHROME-C OXIDASE
(Thermus
thermophilus) 		3 / 3 HIS A 233
HIS A 282
HIS A 283
 CU  A 803 (-3.1A)
HAS  A 801 ( 3.3A)
CU  A 803 ( 3.2A)
 0.22A 2dyrN-1ehkA:
35.8		 2dyrN-1ehkA:
28.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYS_A_CUA601_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 1ehk BA3-TYPE
CYTOCHROME-C OXIDASE
(Thermus
thermophilus) 		3 / 3 HIS A 233
HIS A 282
HIS A 283
 CU  A 803 (-3.1A)
HAS  A 801 ( 3.3A)
CU  A 803 ( 3.2A)
 0.14A 2dysA-1ehkA:
35.9		 2dysA-1ehkA:
28.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYS_N_CUN601_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 1ehk BA3-TYPE
CYTOCHROME-C OXIDASE
(Thermus
thermophilus) 		3 / 3 HIS A 233
HIS A 282
HIS A 283
 CU  A 803 (-3.1A)
HAS  A 801 ( 3.3A)
CU  A 803 ( 3.2A)
 0.13A 2dysN-1ehkA:
35.8		 2dysN-1ehkA:
28.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIJ_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 1ehk BA3-TYPE
CYTOCHROME-C OXIDASE
(Thermus
thermophilus) 		3 / 3 HIS A 233
HIS A 282
HIS A 283
 CU  A 803 (-3.1A)
HAS  A 801 ( 3.3A)
CU  A 803 ( 3.2A)
 0.15A 2eijA-1ehkA:
35.7		 2eijA-1ehkA:
28.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIJ_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 1ehk BA3-TYPE
CYTOCHROME-C OXIDASE
(Thermus
thermophilus) 		3 / 3 HIS A 233
HIS A 282
HIS A 283
 CU  A 803 (-3.1A)
HAS  A 801 ( 3.3A)
CU  A 803 ( 3.2A)
 0.19A 2eijN-1ehkA:
35.8		 2eijN-1ehkA:
28.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIK_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 1ehk BA3-TYPE
CYTOCHROME-C OXIDASE
(Thermus
thermophilus) 		3 / 3 HIS A 233
HIS A 282
HIS A 283
 CU  A 803 (-3.1A)
HAS  A 801 ( 3.3A)
CU  A 803 ( 3.2A)
 0.10A 2eikA-1ehkA:
35.8		 2eikA-1ehkA:
28.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIK_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 1ehk BA3-TYPE
CYTOCHROME-C OXIDASE
(Thermus
thermophilus) 		3 / 3 HIS A 233
HIS A 282
HIS A 283
 CU  A 803 (-3.1A)
HAS  A 801 ( 3.3A)
CU  A 803 ( 3.2A)
 0.22A 2eikN-1ehkA:
35.8		 2eikN-1ehkA:
28.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIL_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 1ehk BA3-TYPE
CYTOCHROME-C OXIDASE
(Thermus
thermophilus) 		3 / 3 HIS A 233
HIS A 282
HIS A 283
 CU  A 803 (-3.1A)
HAS  A 801 ( 3.3A)
CU  A 803 ( 3.2A)
 0.14A 2eilA-1ehkA:
35.8		 2eilA-1ehkA:
28.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIL_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 1ehk BA3-TYPE
CYTOCHROME-C OXIDASE
(Thermus
thermophilus) 		3 / 3 HIS A 233
HIS A 282
HIS A 283
 CU  A 803 (-3.1A)
HAS  A 801 ( 3.3A)
CU  A 803 ( 3.2A)
 0.20A 2eilN-1ehkA:
35.7		 2eilN-1ehkA:
28.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIM_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 1ehk BA3-TYPE
CYTOCHROME-C OXIDASE
(Thermus
thermophilus) 		3 / 3 HIS A 233
HIS A 282
HIS A 283
 CU  A 803 (-3.1A)
HAS  A 801 ( 3.3A)
CU  A 803 ( 3.2A)
 0.22A 2eimA-1ehkA:
35.6		 2eimA-1ehkA:
28.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIM_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 1ehk BA3-TYPE
CYTOCHROME-C OXIDASE
(Thermus
thermophilus) 		3 / 3 HIS A 233
HIS A 282
HIS A 283
 CU  A 803 (-3.1A)
HAS  A 801 ( 3.3A)
CU  A 803 ( 3.2A)
 0.27A 2eimN-1ehkA:
35.6		 2eimN-1ehkA:
28.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIN_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 1ehk BA3-TYPE
CYTOCHROME-C OXIDASE
(Thermus
thermophilus) 		3 / 3 HIS A 233
HIS A 282
HIS A 283
 CU  A 803 (-3.1A)
HAS  A 801 ( 3.3A)
CU  A 803 ( 3.2A)
 0.03A 2einA-1ehkA:
35.7		 2einA-1ehkA:
28.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIN_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 1ehk BA3-TYPE
CYTOCHROME-C OXIDASE
(Thermus
thermophilus) 		3 / 3 HIS A 233
HIS A 282
HIS A 283
 CU  A 803 (-3.1A)
HAS  A 801 ( 3.3A)
CU  A 803 ( 3.2A)
 0.26A 2einN-1ehkA:
35.9		 2einN-1ehkA:
28.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OQE_A_CUA801_0
(PEROXISOMAL COPPER
AMINE OXIDASE)		 1ehk BA3-TYPE
CYTOCHROME-C OXIDASE
(Thermus
thermophilus) 		3 / 3 HIS A 282
HIS A 283
HIS A 233
 HAS  A 801 ( 3.3A)
CU  A 803 ( 3.2A)
CU  A 803 (-3.1A)
 0.59A 2oqeA-1ehkA:
undetectable		 2oqeA-1ehkA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OQE_B_CUB801_0
(PEROXISOMAL COPPER
AMINE OXIDASE)		 1ehk BA3-TYPE
CYTOCHROME-C OXIDASE
(Thermus
thermophilus) 		3 / 3 HIS A 282
HIS A 283
HIS A 233
 HAS  A 801 ( 3.3A)
CU  A 803 ( 3.2A)
CU  A 803 (-3.1A)
 0.57A 2oqeB-1ehkA:
undetectable		 2oqeB-1ehkA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OQE_C_CUC801_0
(PEROXISOMAL COPPER
AMINE OXIDASE)		 1ehk BA3-TYPE
CYTOCHROME-C OXIDASE
(Thermus
thermophilus) 		3 / 3 HIS A 282
HIS A 283
HIS A 233
 HAS  A 801 ( 3.3A)
CU  A 803 ( 3.2A)
CU  A 803 (-3.1A)
 0.58A 2oqeC-1ehkA:
undetectable		 2oqeC-1ehkA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OQE_D_CUD801_0
(PEROXISOMAL COPPER
AMINE OXIDASE)		 1ehk BA3-TYPE
CYTOCHROME-C OXIDASE
(Thermus
thermophilus) 		3 / 3 HIS A 282
HIS A 283
HIS A 233
 HAS  A 801 ( 3.3A)
CU  A 803 ( 3.2A)
CU  A 803 (-3.1A)
 0.56A 2oqeD-1ehkA:
undetectable		 2oqeD-1ehkA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OQE_F_CUF801_0
(PEROXISOMAL COPPER
AMINE OXIDASE)		 1ehk BA3-TYPE
CYTOCHROME-C OXIDASE
(Thermus
thermophilus) 		3 / 3 HIS A 282
HIS A 283
HIS A 233
 HAS  A 801 ( 3.3A)
CU  A 803 ( 3.2A)
CU  A 803 (-3.1A)
 0.57A 2oqeF-1ehkA:
undetectable		 2oqeF-1ehkA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_D_KLND1498_1
(CYTOCHROME P450 3A4)		 2yev CYTOCHROME C OXIDASE
POLYPEPTIDE I+III
CYTOCHROME C OXIDASE
SUBUNIT 2
(Thermus
thermophilus) 		5 / 11 ILE B 183
PHE B  31
ALA B 170
ARG A 447
GLU B 199
 None
None
None
HAS  A1016 ( 3.1A)
MG  A1801 ( 2.6A)
 1.20A 2v0mD-2yevB:
undetectable		 2v0mD-2yevB:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W0Q_A_CUA801_0
(COPPER AMINE OXIDASE)		 1ehk BA3-TYPE
CYTOCHROME-C OXIDASE
(Thermus
thermophilus) 		3 / 3 HIS A 282
HIS A 283
HIS A 233
 HAS  A 801 ( 3.3A)
CU  A 803 ( 3.2A)
CU  A 803 (-3.1A)
 0.62A 2w0qA-1ehkA:
undetectable		 2w0qA-1ehkA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W0Q_B_CUB801_0
(COPPER AMINE OXIDASE)		 1ehk BA3-TYPE
CYTOCHROME-C OXIDASE
(Thermus
thermophilus) 		3 / 3 HIS A 282
HIS A 283
HIS A 233
 HAS  A 801 ( 3.3A)
CU  A 803 ( 3.2A)
CU  A 803 (-3.1A)
 0.62A 2w0qB-1ehkA:
undetectable		 2w0qB-1ehkA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y69_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 1ehk BA3-TYPE
CYTOCHROME-C OXIDASE
(Thermus
thermophilus) 		3 / 3 HIS A 233
HIS A 282
HIS A 283
 CU  A 803 (-3.1A)
HAS  A 801 ( 3.3A)
CU  A 803 ( 3.2A)
 0.17A 2y69A-1ehkA:
35.9		 2y69A-1ehkA:
28.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y69_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 1ehk BA3-TYPE
CYTOCHROME-C OXIDASE
(Thermus
thermophilus) 		3 / 3 HIS A 233
HIS A 282
HIS A 283
 CU  A 803 (-3.1A)
HAS  A 801 ( 3.3A)
CU  A 803 ( 3.2A)
 0.13A 2y69N-1ehkA:
35.8		 2y69N-1ehkA:
28.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZXW_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 1ehk BA3-TYPE
CYTOCHROME-C OXIDASE
(Thermus
thermophilus) 		3 / 3 HIS A 233
HIS A 282
HIS A 283
 CU  A 803 (-3.1A)
HAS  A 801 ( 3.3A)
CU  A 803 ( 3.2A)
 0.23A 2zxwA-1ehkA:
35.7		 2zxwA-1ehkA:
28.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZXW_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 1ehk BA3-TYPE
CYTOCHROME-C OXIDASE
(Thermus
thermophilus) 		3 / 3 HIS A 233
HIS A 282
HIS A 283
 CU  A 803 (-3.1A)
HAS  A 801 ( 3.3A)
CU  A 803 ( 3.2A)
 0.17A 2zxwN-1ehkA:
35.7		 2zxwN-1ehkA:
28.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABK_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 1ehk BA3-TYPE
CYTOCHROME-C OXIDASE
(Thermus
thermophilus) 		3 / 3 HIS A 233
HIS A 282
HIS A 283
 CU  A 803 (-3.1A)
HAS  A 801 ( 3.3A)
CU  A 803 ( 3.2A)
 0.26A 3abkA-1ehkA:
35.8		 3abkA-1ehkA:
28.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABK_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 1ehk BA3-TYPE
CYTOCHROME-C OXIDASE
(Thermus
thermophilus) 		3 / 3 HIS A 233
HIS A 282
HIS A 283
 CU  A 803 (-3.1A)
HAS  A 801 ( 3.3A)
CU  A 803 ( 3.2A)
 0.19A 3abkN-1ehkA:
35.8		 3abkN-1ehkA:
28.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABL_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 1ehk BA3-TYPE
CYTOCHROME-C OXIDASE
(Thermus
thermophilus) 		3 / 3 HIS A 233
HIS A 282
HIS A 283
 CU  A 803 (-3.1A)
HAS  A 801 ( 3.3A)
CU  A 803 ( 3.2A)
 0.16A 3ablA-1ehkA:
35.7		 3ablA-1ehkA:
28.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABL_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 1ehk BA3-TYPE
CYTOCHROME-C OXIDASE
(Thermus
thermophilus) 		3 / 3 HIS A 233
HIS A 282
HIS A 283
 CU  A 803 (-3.1A)
HAS  A 801 ( 3.3A)
CU  A 803 ( 3.2A)
 0.20A 3ablN-1ehkA:
35.7		 3ablN-1ehkA:
28.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABM_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 1ehk BA3-TYPE
CYTOCHROME-C OXIDASE
(Thermus
thermophilus) 		3 / 3 HIS A 233
HIS A 282
HIS A 283
 CU  A 803 (-3.1A)
HAS  A 801 ( 3.3A)
CU  A 803 ( 3.2A)
 0.23A 3abmA-1ehkA:
35.9		 3abmA-1ehkA:
28.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABM_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 1ehk BA3-TYPE
CYTOCHROME-C OXIDASE
(Thermus
thermophilus) 		3 / 3 HIS A 233
HIS A 282
HIS A 283
 CU  A 803 (-3.1A)
HAS  A 801 ( 3.3A)
CU  A 803 ( 3.2A)
 0.07A 3abmN-1ehkA:
35.7		 3abmN-1ehkA:
28.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG1_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 1ehk BA3-TYPE
CYTOCHROME-C OXIDASE
(Thermus
thermophilus) 		3 / 3 HIS A 233
HIS A 282
HIS A 283
 CU  A 803 (-3.1A)
HAS  A 801 ( 3.3A)
CU  A 803 ( 3.2A)
 0.26A 3ag1A-1ehkA:
35.4		 3ag1A-1ehkA:
28.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG1_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 1ehk BA3-TYPE
CYTOCHROME-C OXIDASE
(Thermus
thermophilus) 		3 / 3 HIS A 233
HIS A 282
HIS A 283
 CU  A 803 (-3.1A)
HAS  A 801 ( 3.3A)
CU  A 803 ( 3.2A)
 0.25A 3ag1N-1ehkA:
35.4		 3ag1N-1ehkA:
28.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG2_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 1ehk BA3-TYPE
CYTOCHROME-C OXIDASE
(Thermus
thermophilus) 		3 / 3 HIS A 233
HIS A 282
HIS A 283
 CU  A 803 (-3.1A)
HAS  A 801 ( 3.3A)
CU  A 803 ( 3.2A)
 0.19A 3ag2A-1ehkA:
35.9		 3ag2A-1ehkA:
28.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG2_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 1ehk BA3-TYPE
CYTOCHROME-C OXIDASE
(Thermus
thermophilus) 		3 / 3 HIS A 233
HIS A 282
HIS A 283
 CU  A 803 (-3.1A)
HAS  A 801 ( 3.3A)
CU  A 803 ( 3.2A)
 0.23A 3ag2N-1ehkA:
35.7		 3ag2N-1ehkA:
28.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG3_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 1ehk BA3-TYPE
CYTOCHROME-C OXIDASE
(Thermus
thermophilus) 		3 / 3 HIS A 233
HIS A 282
HIS A 283
 CU  A 803 (-3.1A)
HAS  A 801 ( 3.3A)
CU  A 803 ( 3.2A)
 0.23A 3ag3A-1ehkA:
35.8		 3ag3A-1ehkA:
28.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG3_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 1ehk BA3-TYPE
CYTOCHROME-C OXIDASE
(Thermus
thermophilus) 		3 / 3 HIS A 233
HIS A 282
HIS A 283
 CU  A 803 (-3.1A)
HAS  A 801 ( 3.3A)
CU  A 803 ( 3.2A)
 0.23A 3ag3N-1ehkA:
35.7		 3ag3N-1ehkA:
28.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG4_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 1ehk BA3-TYPE
CYTOCHROME-C OXIDASE
(Thermus
thermophilus) 		3 / 3 HIS A 233
HIS A 282
HIS A 283
 CU  A 803 (-3.1A)
HAS  A 801 ( 3.3A)
CU  A 803 ( 3.2A)
 0.41A 3ag4A-1ehkA:
35.8		 3ag4A-1ehkA:
28.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG4_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 1ehk BA3-TYPE
CYTOCHROME-C OXIDASE
(Thermus
thermophilus) 		3 / 3 HIS A 233
HIS A 282
HIS A 283
 CU  A 803 (-3.1A)
HAS  A 801 ( 3.3A)
CU  A 803 ( 3.2A)
 0.32A 3ag4N-1ehkA:
35.6		 3ag4N-1ehkA:
28.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASN_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 1ehk BA3-TYPE
CYTOCHROME-C OXIDASE
(Thermus
thermophilus) 		3 / 3 HIS A 233
HIS A 282
HIS A 283
 CU  A 803 (-3.1A)
HAS  A 801 ( 3.3A)
CU  A 803 ( 3.2A)
 0.11A 3asnA-1ehkA:
35.9		 3asnA-1ehkA:
28.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASN_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 1ehk BA3-TYPE
CYTOCHROME-C OXIDASE
(Thermus
thermophilus) 		3 / 3 HIS A 233
HIS A 282
HIS A 283
 CU  A 803 (-3.1A)
HAS  A 801 ( 3.3A)
CU  A 803 ( 3.2A)
 0.16A 3asnN-1ehkA:
35.8		 3asnN-1ehkA:
28.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASO_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 1ehk BA3-TYPE
CYTOCHROME-C OXIDASE
(Thermus
thermophilus) 		3 / 3 HIS A 233
HIS A 282
HIS A 283
 CU  A 803 (-3.1A)
HAS  A 801 ( 3.3A)
CU  A 803 ( 3.2A)
 0.14A 3asoA-1ehkA:
35.9		 3asoA-1ehkA:
28.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASO_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 1ehk BA3-TYPE
CYTOCHROME-C OXIDASE
(Thermus
thermophilus) 		3 / 3 HIS A 233
HIS A 282
HIS A 283
 CU  A 803 (-3.1A)
HAS  A 801 ( 3.3A)
CU  A 803 ( 3.2A)
 0.13A 3asoN-1ehkA:
35.8		 3asoN-1ehkA:
28.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3BVD_A_CUA803_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 1ehk BA3-TYPE
CYTOCHROME-C OXIDASE
(Thermus
thermophilus) 		3 / 3 HIS A 233
HIS A 282
HIS A 283
 CU  A 803 (-3.1A)
HAS  A 801 ( 3.3A)
CU  A 803 ( 3.2A)
 0.36A 3bvdA-1ehkA:
61.5		 3bvdA-1ehkA:
98.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DTU_A_CUA1023_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 1ehk BA3-TYPE
CYTOCHROME-C OXIDASE
(Thermus
thermophilus) 		3 / 3 HIS A 233
HIS A 282
HIS A 283
 CU  A 803 (-3.1A)
HAS  A 801 ( 3.3A)
CU  A 803 ( 3.2A)
 0.22A 3dtuA-1ehkA:
36.8		 3dtuA-1ehkA:
26.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DTU_C_CUC569_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 1ehk BA3-TYPE
CYTOCHROME-C OXIDASE
(Thermus
thermophilus) 		3 / 3 HIS A 233
HIS A 282
HIS A 283
 CU  A 803 (-3.1A)
HAS  A 801 ( 3.3A)
CU  A 803 ( 3.2A)
 0.20A 3dtuC-1ehkA:
36.9		 3dtuC-1ehkA:
26.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G4L_D_ROFD904_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 2yev CYTOCHROME C OXIDASE
POLYPEPTIDE I+III
CYTOCHROME C OXIDASE
SUBUNIT 2
(Thermus
thermophilus;
Thermus
thermophilus) 		3 / 3 ASN B  32
MET A 369
PHE B  39
 None
HAS  A1016 ( 4.8A)
None
 0.86A 3g4lD-2yevB:
undetectable		 3g4lD-2yevB:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HII_A_CUA801_0
(AMILORIDE-SENSITIVE
AMINE OXIDASE)		 1ehk BA3-TYPE
CYTOCHROME-C OXIDASE
(Thermus
thermophilus) 		3 / 3 HIS A 282
HIS A 283
HIS A 233
 HAS  A 801 ( 3.3A)
CU  A 803 ( 3.2A)
CU  A 803 (-3.1A)
 0.51A 3hiiA-1ehkA:
undetectable		 3hiiA-1ehkA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HII_B_CUB801_0
(AMILORIDE-SENSITIVE
AMINE OXIDASE)		 1ehk BA3-TYPE
CYTOCHROME-C OXIDASE
(Thermus
thermophilus) 		3 / 3 HIS A 282
HIS A 283
HIS A 233
 HAS  A 801 ( 3.3A)
CU  A 803 ( 3.2A)
CU  A 803 (-3.1A)
 0.52A 3hiiB-1ehkA:
undetectable		 3hiiB-1ehkA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LCV_B_SAMB301_0
(SISOMICIN-GENTAMICIN
RESISTANCE METHYLASE
SGM)		 2yev CYTOCHROME C OXIDASE
POLYPEPTIDE I+III
(Thermus
thermophilus) 		5 / 12 TYR A 254
SER A 208
ALA A 201
LEU A  87
LEU A 206
 HAS  A1016 (-4.4A)
None
None
None
None
 1.37A 3lcvB-2yevA:
undetectable		 3lcvB-2yevA:
15.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3S33_A_CUA803_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 1ehk BA3-TYPE
CYTOCHROME-C OXIDASE
(Thermus
thermophilus) 		3 / 3 HIS A 233
HIS A 282
HIS A 283
 CU  A 803 (-3.1A)
HAS  A 801 ( 3.3A)
CU  A 803 ( 3.2A)
 0.28A 3s33A-1ehkA:
62.4		 3s33A-1ehkA:
98.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3S38_A_CUA803_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 1ehk BA3-TYPE
CYTOCHROME-C OXIDASE
(Thermus
thermophilus) 		3 / 3 HIS A 233
HIS A 282
HIS A 283
 CU  A 803 (-3.1A)
HAS  A 801 ( 3.3A)
CU  A 803 ( 3.2A)
 0.37A 3s38A-1ehkA:
60.9		 3s38A-1ehkA:
98.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3S39_A_CUA803_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 1ehk BA3-TYPE
CYTOCHROME-C OXIDASE
(Thermus
thermophilus) 		3 / 3 HIS A 233
HIS A 282
HIS A 283
 CU  A 803 (-3.1A)
HAS  A 801 ( 3.3A)
CU  A 803 ( 3.2A)
 0.26A 3s39A-1ehkA:
62.5		 3s39A-1ehkA:
98.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3S3A_A_CUA803_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 1ehk BA3-TYPE
CYTOCHROME-C OXIDASE
(Thermus
thermophilus) 		3 / 3 HIS A 233
HIS A 282
HIS A 283
 CU  A 803 (-3.1A)
HAS  A 801 ( 3.3A)
CU  A 803 ( 3.2A)
 0.32A 3s3aA-1ehkA:
59.8		 3s3aA-1ehkA:
98.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3S3B_A_CUA803_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 1ehk BA3-TYPE
CYTOCHROME-C OXIDASE
(Thermus
thermophilus) 		3 / 3 HIS A 233
HIS A 282
HIS A 283
 CU  A 803 (-3.1A)
HAS  A 801 ( 3.3A)
CU  A 803 ( 3.2A)
 0.26A 3s3bA-1ehkA:
63.1		 3s3bA-1ehkA:
98.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3S3C_A_CUA803_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 1ehk BA3-TYPE
CYTOCHROME-C OXIDASE
(Thermus
thermophilus) 		3 / 3 HIS A 233
HIS A 282
HIS A 283
 CU  A 803 (-3.1A)
HAS  A 801 ( 3.3A)
CU  A 803 ( 3.2A)
 0.35A 3s3cA-1ehkA:
62.3		 3s3cA-1ehkA:
98.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3S3D_A_CUA803_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 1ehk BA3-TYPE
CYTOCHROME-C OXIDASE
(Thermus
thermophilus) 		3 / 3 HIS A 233
HIS A 282
HIS A 283
 CU  A 803 (-3.1A)
HAS  A 801 ( 3.3A)
CU  A 803 ( 3.2A)
 0.29A 3s3dA-1ehkA:
62.5		 3s3dA-1ehkA:
98.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TM4_A_SAMA401_0
(TRNA (GUANINE
N2-)-METHYLTRANSFERA
SE TRM14)		 1ehk BA3-TYPE
CYTOCHROME-C OXIDASE
(Thermus
thermophilus) 		5 / 12 ALA A 367
LEU A 371
GLY A 362
HIS A 384
LEU A 310
 HAS  A 801 (-3.4A)
None
None
HAS  A 801 (-4.4A)
HAS  A 801 (-4.0A)
 1.23A 3tm4A-1ehkA:
undetectable		 3tm4A-1ehkA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TM4_B_SAMB401_0
(TRNA (GUANINE
N2-)-METHYLTRANSFERA
SE TRM14)		 1ehk BA3-TYPE
CYTOCHROME-C OXIDASE
(Thermus
thermophilus) 		5 / 12 ALA A 367
LEU A 371
GLY A 362
HIS A 384
LEU A 310
 HAS  A 801 (-3.4A)
None
None
HAS  A 801 (-4.4A)
HAS  A 801 (-4.0A)
 1.22A 3tm4B-1ehkA:
undetectable		 3tm4B-1ehkA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WG7_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 1ehk BA3-TYPE
CYTOCHROME-C OXIDASE
(Thermus
thermophilus) 		3 / 3 HIS A 233
HIS A 282
HIS A 283
 CU  A 803 (-3.1A)
HAS  A 801 ( 3.3A)
CU  A 803 ( 3.2A)
 0.06A 3wg7A-1ehkA:
35.6		 3wg7A-1ehkA:
28.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WG7_N_CUN603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 1ehk BA3-TYPE
CYTOCHROME-C OXIDASE
(Thermus
thermophilus) 		3 / 3 HIS A 233
HIS A 282
HIS A 283
 CU  A 803 (-3.1A)
HAS  A 801 ( 3.3A)
CU  A 803 ( 3.2A)
 0.17A 3wg7N-1ehkA:
35.6		 3wg7N-1ehkA:
28.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_B_ACHB301_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 2yev CYTOCHROME C OXIDASE
POLYPEPTIDE I+III
(Thermus
thermophilus) 		4 / 8 TYR A 380
THR A 451
TYR A 449
TRP A 459
 HAS  A1015 (-4.9A)
None
None
None
 1.43A 3wipB-2yevA:
undetectable
3wipC-2yevA:
undetectable		 3wipB-2yevA:
13.22
3wipC-2yevA:
13.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_B_ACHB301_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 2yev CYTOCHROME C OXIDASE
POLYPEPTIDE I+III
CYTOCHROME C OXIDASE
SUBUNIT 2
(Thermus
thermophilus;
Thermus
thermophilus) 		4 / 8 TYR A 442
THR A 363
TYR B  43
MET A 369
 4AG  A1200 (-3.5A)
None
None
HAS  A1016 ( 4.8A)
 1.44A 3wipB-2yevA:
undetectable
3wipC-2yevA:
undetectable		 3wipB-2yevA:
13.22
3wipC-2yevA:
13.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_C_ACHC301_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 2yev CYTOCHROME C OXIDASE
POLYPEPTIDE I+III
(Thermus
thermophilus) 		4 / 8 TYR A 380
THR A 451
TYR A 449
TRP A 459
 HAS  A1015 (-4.9A)
None
None
None
 1.44A 3wipC-2yevA:
undetectable
3wipD-2yevA:
undetectable		 3wipC-2yevA:
13.22
3wipD-2yevA:
13.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_C_ACHC301_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 2yev CYTOCHROME C OXIDASE
POLYPEPTIDE I+III
CYTOCHROME C OXIDASE
SUBUNIT 2
(Thermus
thermophilus;
Thermus
thermophilus) 		4 / 8 TYR A 442
THR A 363
TYR B  43
MET A 369
 4AG  A1200 (-3.5A)
None
None
HAS  A1016 ( 4.8A)
 1.45A 3wipC-2yevA:
undetectable
3wipD-2yevA:
undetectable		 3wipC-2yevA:
13.22
3wipD-2yevA:
13.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_E_ACHE301_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 2yev CYTOCHROME C OXIDASE
POLYPEPTIDE I+III
(Thermus
thermophilus) 		4 / 8 TRP A 459
TYR A 380
THR A 451
TYR A 449
 None
HAS  A1015 (-4.9A)
None
None
 1.42A 3wipA-2yevA:
undetectable
3wipE-2yevA:
undetectable		 3wipA-2yevA:
13.22
3wipE-2yevA:
13.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_E_ACHE301_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 2yev CYTOCHROME C OXIDASE
POLYPEPTIDE I+III
CYTOCHROME C OXIDASE
SUBUNIT 2
(Thermus
thermophilus;
Thermus
thermophilus) 		4 / 8 MET A 369
TYR A 442
THR A 363
TYR B  43
 HAS  A1016 ( 4.8A)
4AG  A1200 (-3.5A)
None
None
 1.49A 3wipA-2yevA:
undetectable
3wipE-2yevA:
undetectable		 3wipA-2yevA:
13.22
3wipE-2yevA:
13.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3X2Q_A_CUA604_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 1ehk BA3-TYPE
CYTOCHROME-C OXIDASE
(Thermus
thermophilus) 		3 / 3 HIS A 233
HIS A 282
HIS A 283
 CU  A 803 (-3.1A)
HAS  A 801 ( 3.3A)
CU  A 803 ( 3.2A)
 0.21A 3x2qA-1ehkA:
35.8		 3x2qA-1ehkA:
28.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3X2Q_N_CUN604_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 1ehk BA3-TYPE
CYTOCHROME-C OXIDASE
(Thermus
thermophilus) 		3 / 3 HIS A 233
HIS A 282
HIS A 283
 CU  A 803 (-3.1A)
HAS  A 801 ( 3.3A)
CU  A 803 ( 3.2A)
 0.06A 3x2qN-1ehkA:
35.8		 3x2qN-1ehkA:
28.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A84_A_DXCA1161_0
(MAJOR POLLEN
ALLERGEN BET V 1-A)		 1ehk BA3-TYPE
CYTOCHROME-C OXIDASE
(Thermus
thermophilus) 		5 / 12 PHE A 385
PRO A 382
LEU A 439
TYR A  46
GLN A  42
 HAS  A 801 ( 3.7A)
None
None
HEM  A 800 (-4.5A)
HEM  A 800 (-4.4A)
 1.47A 4a84A-1ehkA:
undetectable		 4a84A-1ehkA:
14.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_A_SORA1342_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 2yev CYTOCHROME C OXIDASE
POLYPEPTIDE I+III
(Thermus
thermophilus) 		4 / 7 ILE A 481
LEU A 478
GLY A 476
GLY A 477
 None
None
None
HAS  A1015 ( 3.7A)
 0.86A 5a06A-2yevA:
undetectable		 5a06A-2yevA:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_C_SORC1342_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 2yev CYTOCHROME C OXIDASE
POLYPEPTIDE I+III
(Thermus
thermophilus) 		4 / 7 ILE A 481
LEU A 478
GLY A 476
GLY A 477
 None
None
None
HAS  A1015 ( 3.7A)
 0.85A 5a06C-2yevA:
undetectable		 5a06C-2yevA:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_F_SORF1341_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 2yev CYTOCHROME C OXIDASE
POLYPEPTIDE I+III
(Thermus
thermophilus) 		4 / 7 ILE A 481
LEU A 478
GLY A 476
GLY A 477
 None
None
None
HAS  A1015 ( 3.7A)
 0.85A 5a06F-2yevA:
undetectable		 5a06F-2yevA:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1A_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 1ehk BA3-TYPE
CYTOCHROME-C OXIDASE
(Thermus
thermophilus) 		3 / 3 HIS A 233
HIS A 282
HIS A 283
 CU  A 803 (-3.1A)
HAS  A 801 ( 3.3A)
CU  A 803 ( 3.2A)
 0.12A 5b1aA-1ehkA:
35.8		 5b1aA-1ehkA:
28.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1A_N_CUN603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 1ehk BA3-TYPE
CYTOCHROME-C OXIDASE
(Thermus
thermophilus) 		3 / 3 HIS A 233
HIS A 282
HIS A 283
 CU  A 803 (-3.1A)
HAS  A 801 ( 3.3A)
CU  A 803 ( 3.2A)
 0.21A 5b1aN-1ehkA:
35.9		 5b1aN-1ehkA:
28.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1B_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 1ehk BA3-TYPE
CYTOCHROME-C OXIDASE
(Thermus
thermophilus) 		3 / 3 HIS A 233
HIS A 282
HIS A 283
 CU  A 803 (-3.1A)
HAS  A 801 ( 3.3A)
CU  A 803 ( 3.2A)
 0.20A 5b1bA-1ehkA:
35.8		 5b1bA-1ehkA:
28.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1B_N_CUN603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 1ehk BA3-TYPE
CYTOCHROME-C OXIDASE
(Thermus
thermophilus) 		3 / 3 HIS A 233
HIS A 282
HIS A 283
 CU  A 803 (-3.1A)
HAS  A 801 ( 3.3A)
CU  A 803 ( 3.2A)
 0.24A 5b1bN-1ehkA:
35.7		 5b1bN-1ehkA:
28.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B3S_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 1ehk BA3-TYPE
CYTOCHROME-C OXIDASE
(Thermus
thermophilus) 		3 / 3 HIS A 233
HIS A 282
HIS A 283
 CU  A 803 (-3.1A)
HAS  A 801 ( 3.3A)
CU  A 803 ( 3.2A)
 0.18A 5b3sA-1ehkA:
35.9		 5b3sA-1ehkA:
28.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B3S_N_CUN603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 1ehk BA3-TYPE
CYTOCHROME-C OXIDASE
(Thermus
thermophilus) 		3 / 3 HIS A 233
HIS A 282
HIS A 283
 CU  A 803 (-3.1A)
HAS  A 801 ( 3.3A)
CU  A 803 ( 3.2A)
 0.24A 5b3sN-1ehkA:
35.8		 5b3sN-1ehkA:
28.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIK_A_SAMA301_0
(GLYCINE SARCOSINE
N-METHYLTRANSFERASE)		 2yev CYTOCHROME C OXIDASE
POLYPEPTIDE I+III
(Thermus
thermophilus) 		5 / 12 GLY A 395
SER A 394
MET A 256
GLY A  74
HIS A 387
 None
HAS  A1016 (-3.7A)
None
HAS  A1015 (-3.7A)
HAS  A1015 (-3.2A)
 1.20A 5hikA-2yevA:
undetectable		 5hikA-2yevA:
15.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IY5_A_CUA601_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 1ehk BA3-TYPE
CYTOCHROME-C OXIDASE
(Thermus
thermophilus) 		3 / 3 HIS A 233
HIS A 282
HIS A 283
 CU  A 803 (-3.1A)
HAS  A 801 ( 3.3A)
CU  A 803 ( 3.2A)
 0.18A 5iy5A-1ehkA:
35.8		 5iy5A-1ehkA:
28.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IY5_N_CUN602_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 1ehk BA3-TYPE
CYTOCHROME-C OXIDASE
(Thermus
thermophilus) 		3 / 3 HIS A 233
HIS A 282
HIS A 283
 CU  A 803 (-3.1A)
HAS  A 801 ( 3.3A)
CU  A 803 ( 3.2A)
 0.19A 5iy5N-1ehkA:
35.7		 5iy5N-1ehkA:
28.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MSD_A_BEZA1202_0
(CARBOXYLIC ACID
REDUCTASE)		 2yev CYTOCHROME C OXIDASE
POLYPEPTIDE I+III
(Thermus
thermophilus) 		4 / 5 ILE A 263
PHE A 353
SER A 394
ALA A 400
 None
None
HAS  A1016 (-3.7A)
None
 1.09A 5msdA-2yevA:
undetectable		 5msdA-2yevA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MZJ_A_TEPA2401_1
(ADENOSINE RECEPTOR
A2A,SOLUBLE
CYTOCHROME
B562,ADENOSINE
RECEPTOR A2A)		 2yev CYTOCHROME C OXIDASE
POLYPEPTIDE I+III
(Thermus
thermophilus) 		4 / 8 LEU A 257
PHE A 353
LEU A 329
ILE A 332
 HAS  A1016 ( 3.9A)
None
None
None
 0.84A 5mzjA-2yevA:
8.9		 5mzjA-2yevA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W97_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 1ehk BA3-TYPE
CYTOCHROME-C OXIDASE
(Thermus
thermophilus) 		3 / 3 HIS A 233
HIS A 282
HIS A 283
 CU  A 803 (-3.1A)
HAS  A 801 ( 3.3A)
CU  A 803 ( 3.2A)
 0.23A 5w97a-1ehkA:
35.5		 5w97a-1ehkA:
28.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WAU_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 1ehk BA3-TYPE
CYTOCHROME-C OXIDASE
(Thermus
thermophilus) 		3 / 3 HIS A 233
HIS A 282
HIS A 283
 CU  A 803 (-3.1A)
HAS  A 801 ( 3.3A)
CU  A 803 ( 3.2A)
 0.22A 5waua-1ehkA:
35.9		 5waua-1ehkA:
28.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X19_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 1ehk BA3-TYPE
CYTOCHROME-C OXIDASE
(Thermus
thermophilus) 		3 / 3 HIS A 233
HIS A 282
HIS A 283
 CU  A 803 (-3.1A)
HAS  A 801 ( 3.3A)
CU  A 803 ( 3.2A)
 0.25A 5x19A-1ehkA:
35.5		 5x19A-1ehkA:
28.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X19_N_CUN603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 1ehk BA3-TYPE
CYTOCHROME-C OXIDASE
(Thermus
thermophilus) 		3 / 3 HIS A 233
HIS A 282
HIS A 283
 CU  A 803 (-3.1A)
HAS  A 801 ( 3.3A)
CU  A 803 ( 3.2A)
 0.26A 5x19N-1ehkA:
35.4		 5x19N-1ehkA:
28.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1B_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 1ehk BA3-TYPE
CYTOCHROME-C OXIDASE
(Thermus
thermophilus) 		3 / 3 HIS A 233
HIS A 282
HIS A 283
 CU  A 803 (-3.1A)
HAS  A 801 ( 3.3A)
CU  A 803 ( 3.2A)
 0.25A 5x1bA-1ehkA:
35.1		 5x1bA-1ehkA:
28.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1B_N_CUN603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 1ehk BA3-TYPE
CYTOCHROME-C OXIDASE
(Thermus
thermophilus) 		3 / 3 HIS A 233
HIS A 282
HIS A 283
 CU  A 803 (-3.1A)
HAS  A 801 ( 3.3A)
CU  A 803 ( 3.2A)
 0.20A 5x1bN-1ehkA:
34.9		 5x1bN-1ehkA:
28.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1F_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 1ehk BA3-TYPE
CYTOCHROME-C OXIDASE
(Thermus
thermophilus) 		3 / 3 HIS A 233
HIS A 282
HIS A 283
 CU  A 803 (-3.1A)
HAS  A 801 ( 3.3A)
CU  A 803 ( 3.2A)
 0.28A 5x1fA-1ehkA:
35.4		 5x1fA-1ehkA:
28.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1F_N_CUN603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 1ehk BA3-TYPE
CYTOCHROME-C OXIDASE
(Thermus
thermophilus) 		3 / 3 HIS A 233
HIS A 282
HIS A 283
 CU  A 803 (-3.1A)
HAS  A 801 ( 3.3A)
CU  A 803 ( 3.2A)
 0.19A 5x1fN-1ehkA:
35.5		 5x1fN-1ehkA:
28.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDQ_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 1ehk BA3-TYPE
CYTOCHROME-C OXIDASE
(Thermus
thermophilus) 		3 / 3 HIS A 233
HIS A 282
HIS A 283
 CU  A 803 (-3.1A)
HAS  A 801 ( 3.3A)
CU  A 803 ( 3.2A)
 0.13A 5xdqA-1ehkA:
36.0		 5xdqA-1ehkA:
28.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDQ_N_CUN603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 1ehk BA3-TYPE
CYTOCHROME-C OXIDASE
(Thermus
thermophilus) 		3 / 3 HIS A 233
HIS A 282
HIS A 283
 CU  A 803 (-3.1A)
HAS  A 801 ( 3.3A)
CU  A 803 ( 3.2A)
 0.16A 5xdqN-1ehkA:
35.8		 5xdqN-1ehkA:
28.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDX_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 1ehk BA3-TYPE
CYTOCHROME-C OXIDASE
(Thermus
thermophilus) 		3 / 3 HIS A 233
HIS A 282
HIS A 283
 CU  A 803 (-3.1A)
HAS  A 801 ( 3.3A)
CU  A 803 ( 3.2A)
 0.15A 5xdxA-1ehkA:
36.0		 5xdxA-1ehkA:
28.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDX_N_CUN603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 1ehk BA3-TYPE
CYTOCHROME-C OXIDASE
(Thermus
thermophilus) 		3 / 3 HIS A 233
HIS A 282
HIS A 283
 CU  A 803 (-3.1A)
HAS  A 801 ( 3.3A)
CU  A 803 ( 3.2A)
 0.14A 5xdxN-1ehkA:
35.8		 5xdxN-1ehkA:
28.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YBB_A_SAMA601_0
(TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLTRANSFERASE
SUBUNIT)		 2yev CYTOCHROME C OXIDASE
POLYPEPTIDE I+III
(Thermus
thermophilus) 		5 / 12 GLY A 361
GLY A 364
LEU A 264
ASN A 388
PHE A 353
 HAS  A1016 (-3.3A)
HAS  A1016 (-3.7A)
None
None
None
 1.10A 5ybbA-2yevA:
undetectable		 5ybbA-2yevA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z84_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 1ehk BA3-TYPE
CYTOCHROME-C OXIDASE
(Thermus
thermophilus) 		3 / 3 HIS A 233
HIS A 282
HIS A 283
 CU  A 803 (-3.1A)
HAS  A 801 ( 3.3A)
CU  A 803 ( 3.2A)
 0.18A 5z84A-1ehkA:
35.9		 5z84A-1ehkA:
28.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z84_N_CUN604_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 1ehk BA3-TYPE
CYTOCHROME-C OXIDASE
(Thermus
thermophilus) 		3 / 3 HIS A 233
HIS A 282
HIS A 283
 CU  A 803 (-3.1A)
HAS  A 801 ( 3.3A)
CU  A 803 ( 3.2A)
 0.18A 5z84N-1ehkA:
35.8		 5z84N-1ehkA:
28.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z85_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 1ehk BA3-TYPE
CYTOCHROME-C OXIDASE
(Thermus
thermophilus) 		3 / 3 HIS A 233
HIS A 282
HIS A 283
 CU  A 803 (-3.1A)
HAS  A 801 ( 3.3A)
CU  A 803 ( 3.2A)
 0.20A 5z85A-1ehkA:
35.9		 5z85A-1ehkA:
28.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z85_N_CUN603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 1ehk BA3-TYPE
CYTOCHROME-C OXIDASE
(Thermus
thermophilus) 		3 / 3 HIS A 233
HIS A 282
HIS A 283
 CU  A 803 (-3.1A)
HAS  A 801 ( 3.3A)
CU  A 803 ( 3.2A)
 0.17A 5z85N-1ehkA:
35.8		 5z85N-1ehkA:
28.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z86_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 1ehk BA3-TYPE
CYTOCHROME-C OXIDASE
(Thermus
thermophilus) 		3 / 3 HIS A 233
HIS A 282
HIS A 283
 CU  A 803 (-3.1A)
HAS  A 801 ( 3.3A)
CU  A 803 ( 3.2A)
 0.00A 5z86A-1ehkA:
36.0		 5z86A-1ehkA:
28.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z86_N_CUN603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 1ehk BA3-TYPE
CYTOCHROME-C OXIDASE
(Thermus
thermophilus) 		3 / 3 HIS A 233
HIS A 282
HIS A 283
 CU  A 803 (-3.1A)
HAS  A 801 ( 3.3A)
CU  A 803 ( 3.2A)
 0.16A 5z86N-1ehkA:
35.8		 5z86N-1ehkA:
28.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCO_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 1ehk BA3-TYPE
CYTOCHROME-C OXIDASE
(Thermus
thermophilus) 		3 / 3 HIS A 233
HIS A 282
HIS A 283
 CU  A 803 (-3.1A)
HAS  A 801 ( 3.3A)
CU  A 803 ( 3.2A)
 0.17A 5zcoA-1ehkA:
35.8		 5zcoA-1ehkA:
28.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCO_N_CUN604_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 1ehk BA3-TYPE
CYTOCHROME-C OXIDASE
(Thermus
thermophilus) 		3 / 3 HIS A 233
HIS A 282
HIS A 283
 CU  A 803 (-3.1A)
HAS  A 801 ( 3.3A)
CU  A 803 ( 3.2A)
 0.07A 5zcoN-1ehkA:
35.7		 5zcoN-1ehkA:
28.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCP_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 1ehk BA3-TYPE
CYTOCHROME-C OXIDASE
(Thermus
thermophilus) 		3 / 3 HIS A 233
HIS A 282
HIS A 283
 CU  A 803 (-3.1A)
HAS  A 801 ( 3.3A)
CU  A 803 ( 3.2A)
 0.12A 5zcpA-1ehkA:
35.8		 5zcpA-1ehkA:
28.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCP_N_CUN604_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 1ehk BA3-TYPE
CYTOCHROME-C OXIDASE
(Thermus
thermophilus) 		3 / 3 HIS A 233
HIS A 282
HIS A 283
 CU  A 803 (-3.1A)
HAS  A 801 ( 3.3A)
CU  A 803 ( 3.2A)
 0.19A 5zcpN-1ehkA:
35.8		 5zcpN-1ehkA:
28.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCQ_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 1ehk BA3-TYPE
CYTOCHROME-C OXIDASE
(Thermus
thermophilus) 		3 / 3 HIS A 233
HIS A 282
HIS A 283
 CU  A 803 (-3.1A)
HAS  A 801 ( 3.3A)
CU  A 803 ( 3.2A)
 0.08A 5zcqA-1ehkA:
35.9		 5zcqA-1ehkA:
28.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCQ_N_CUN603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 1ehk BA3-TYPE
CYTOCHROME-C OXIDASE
(Thermus
thermophilus) 		3 / 3 HIS A 233
HIS A 282
HIS A 283
 CU  A 803 (-3.1A)
HAS  A 801 ( 3.3A)
CU  A 803 ( 3.2A)
 0.10A 5zcqN-1ehkA:
35.9		 5zcqN-1ehkA:
28.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GIQ_A_CUA601_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 1ehk BA3-TYPE
CYTOCHROME-C OXIDASE
(Thermus
thermophilus) 		3 / 3 HIS A 233
HIS A 282
HIS A 283
 CU  A 803 (-3.1A)
HAS  A 801 ( 3.3A)
CU  A 803 ( 3.2A)
 0.68A 6giqa-1ehkA:
33.0		 6giqa-1ehkA:
27.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_A_CUA601_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 1ehk BA3-TYPE
CYTOCHROME-C OXIDASE
(Thermus
thermophilus) 		3 / 3 HIS A 233
HIS A 282
HIS A 283
 CU  A 803 (-3.1A)
HAS  A 801 ( 3.3A)
CU  A 803 ( 3.2A)
 0.12A 6hu9a-1ehkA:
34.8		 6hu9a-1ehkA:
27.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_M_CUM601_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 1ehk BA3-TYPE
CYTOCHROME-C OXIDASE
(Thermus
thermophilus) 		3 / 3 HIS A 233
HIS A 282
HIS A 283
 CU  A 803 (-3.1A)
HAS  A 801 ( 3.3A)
CU  A 803 ( 3.2A)
 0.21A 6hu9m-1ehkA:
34.8		 6hu9m-1ehkA:
27.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NKN_A_CUA601_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 1ehk BA3-TYPE
CYTOCHROME-C OXIDASE
(Thermus
thermophilus) 		3 / 3 HIS A 233
HIS A 282
HIS A 283
 CU  A 803 (-3.1A)
HAS  A 801 ( 3.3A)
CU  A 803 ( 3.2A)
 0.17A 6nknA-1ehkA:
35.2		 6nknA-1ehkA:
28.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NKN_N_CUN602_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 1ehk BA3-TYPE
CYTOCHROME-C OXIDASE
(Thermus
thermophilus) 		3 / 3 HIS A 233
HIS A 282
HIS A 283
 CU  A 803 (-3.1A)
HAS  A 801 ( 3.3A)
CU  A 803 ( 3.2A)
 0.15A 6nknN-1ehkA:
35.2		 6nknN-1ehkA:
28.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMF_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 1ehk BA3-TYPE
CYTOCHROME-C OXIDASE
(Thermus
thermophilus) 		3 / 3 HIS A 233
HIS A 282
HIS A 283
 CU  A 803 (-3.1A)
HAS  A 801 ( 3.3A)
CU  A 803 ( 3.2A)
 0.24A 6nmfA-1ehkA:
35.3		 6nmfA-1ehkA:
28.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMF_N_CUN603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 1ehk BA3-TYPE
CYTOCHROME-C OXIDASE
(Thermus
thermophilus) 		3 / 3 HIS A 233
HIS A 282
HIS A 283
 CU  A 803 (-3.1A)
HAS  A 801 ( 3.3A)
CU  A 803 ( 3.2A)
 0.25A 6nmfN-1ehkA:
35.0		 6nmfN-1ehkA:
28.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMP_A_CUA601_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 1ehk BA3-TYPE
CYTOCHROME-C OXIDASE
(Thermus
thermophilus) 		3 / 3 HIS A 233
HIS A 282
HIS A 283
 CU  A 803 (-3.1A)
HAS  A 801 ( 3.3A)
CU  A 803 ( 3.2A)
 0.20A 6nmpA-1ehkA:
35.4		 6nmpA-1ehkA:
28.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMP_N_CUN601_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 1ehk BA3-TYPE
CYTOCHROME-C OXIDASE
(Thermus
thermophilus) 		3 / 3 HIS A 233
HIS A 282
HIS A 283
 CU  A 803 (-3.1A)
HAS  A 801 ( 3.3A)
CU  A 803 ( 3.2A)
 0.21A 6nmpN-1ehkA:
35.3		 6nmpN-1ehkA:
28.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6PAH_A_DAHA600_1
(PHENYLALANINE
4-MONOOXYGENASE)		 2yev CYTOCHROME C OXIDASE
POLYPEPTIDE I+III
(Thermus
thermophilus) 		4 / 6 LEU A 390
HIS A 300
HIS A 299
TYR A 254
 HAS  A1015 ( 3.6A)
CU  A1017 ( 3.1A)
CU  A1017 ( 3.3A)
HAS  A1016 (-4.4A)
 0.98A 6pahA-2yevA:
undetectable		 6pahA-2yevA:
16.39