SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'H8H'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FMO_E_ADNE351_1
(CAMP-DEPENDENT
PROTEIN KINASE)		 2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Homo
sapiens) 		8 / 12 LEU A 273
GLY A 274
VAL A 281
ALA A 293
VAL A 323
ASN A 391
LEU A 393
ASP A 404
 H8H  A 534 (-3.8A)
H8H  A 534 ( 3.8A)
H8H  A 534 (-4.4A)
H8H  A 534 (-3.2A)
None
H8H  A 534 ( 4.9A)
H8H  A 534 (-4.5A)
H8H  A 534 (-4.2A)
 0.87A 1fmoE-2h8hA:
22.1		 1fmoE-2h8hA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IEP_A_STIA201_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL)		 2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Homo
sapiens) 		7 / 12 LEU A 273
VAL A 281
ALA A 293
THR A 338
GLY A 344
LEU A 393
ALA A 403
 H8H  A 534 (-3.8A)
H8H  A 534 (-4.4A)
H8H  A 534 (-3.2A)
H8H  A 534 (-3.1A)
H8H  A 534 (-3.3A)
H8H  A 534 (-4.5A)
H8H  A 534 ( 4.0A)
 0.82A 1iepA-2h8hA:
30.3		 1iepA-2h8hA:
28.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IEP_B_STIB202_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL)		 2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Homo
sapiens) 		6 / 12 LEU A 273
VAL A 281
ALA A 293
THR A 338
GLY A 344
ALA A 403
 H8H  A 534 (-3.8A)
H8H  A 534 (-4.4A)
H8H  A 534 (-3.2A)
H8H  A 534 (-3.1A)
H8H  A 534 (-3.3A)
H8H  A 534 ( 4.0A)
 0.82A 1iepB-2h8hA:
30.4		 1iepB-2h8hA:
28.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IEP_B_STIB202_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL)		 5vcx MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE
(Homo
sapiens) 		6 / 12 LEU A 116
VAL A 124
ALA A 137
GLU A 157
THR A 187
GLY A 191
 H8H  A 401 (-3.7A)
H8H  A 401 (-4.7A)
H8H  A 401 (-3.3A)
None
H8H  A 401 (-3.5A)
H8H  A 401 (-4.4A)
 0.84A 1iepB-5vcxA:
18.1		 1iepB-5vcxA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M17_A_AQ4A999_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Homo
sapiens) 		7 / 12 LEU A 273
ALA A 293
LYS A 295
THR A 338
MET A 341
GLY A 344
LEU A 393
 H8H  A 534 (-3.8A)
H8H  A 534 (-3.2A)
H8H  A 534 (-3.7A)
H8H  A 534 (-3.1A)
None
H8H  A 534 (-3.3A)
H8H  A 534 (-4.5A)
 0.50A 1m17A-2h8hA:
29.6		 1m17A-2h8hA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M17_A_AQ4A999_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 5vcx MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE
(Homo
sapiens) 		7 / 12 LEU A 116
ALA A 137
GLU A 157
LEU A 185
THR A 187
LEU A 189
ASP A 251
 H8H  A 401 (-3.7A)
H8H  A 401 (-3.3A)
None
H8H  A 401 (-4.3A)
H8H  A 401 (-3.5A)
None
EDO  A 402 ( 2.9A)
 0.75A 1m17A-5vcxA:
24.5		 1m17A-5vcxA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M17_A_AQ4A999_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 5vcx MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE
(Homo
sapiens) 		7 / 12 LEU A 116
ALA A 137
LYS A 139
GLU A 157
LEU A 185
THR A 187
LEU A 189
 H8H  A 401 (-3.7A)
H8H  A 401 (-3.3A)
H8H  A 401 (-4.9A)
None
H8H  A 401 (-4.3A)
H8H  A 401 (-3.5A)
None
 0.89A 1m17A-5vcxA:
24.5		 1m17A-5vcxA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MUO_A_ADNA1_1
(AURORA-RELATED
KINASE 1)		 2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Homo
sapiens) 		6 / 9 LEU A 273
GLY A 274
VAL A 281
ALA A 293
TYR A 340
LEU A 393
 H8H  A 534 (-3.8A)
H8H  A 534 ( 3.8A)
H8H  A 534 (-4.4A)
H8H  A 534 (-3.2A)
H8H  A 534 (-4.3A)
H8H  A 534 (-4.5A)
 0.89A 1muoA-2h8hA:
7.8		 1muoA-2h8hA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OPJ_A_STIA3_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Homo
sapiens) 		7 / 12 LEU A 273
VAL A 281
ALA A 293
VAL A 323
THR A 338
LEU A 393
ALA A 403
 H8H  A 534 (-3.8A)
H8H  A 534 (-4.4A)
H8H  A 534 (-3.2A)
None
H8H  A 534 (-3.1A)
H8H  A 534 (-4.5A)
H8H  A 534 ( 4.0A)
 0.85A 1opjA-2h8hA:
29.7		 1opjA-2h8hA:
28.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OPJ_B_STIB4_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 5vcx MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE
(Homo
sapiens) 		6 / 12 VAL A 124
ALA A 137
GLU A 157
VAL A 171
THR A 187
GLY A 191
 H8H  A 401 (-4.7A)
H8H  A 401 (-3.3A)
None
None
H8H  A 401 (-3.5A)
H8H  A 401 (-4.4A)
 0.90A 1opjB-5vcxA:
17.6		 1opjB-5vcxA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWH_A_BAXA1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 5vcx MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE
(Homo
sapiens) 		7 / 12 ALA A 137
GLU A 157
THR A 187
CYH A 190
LEU A 224
HIS A 231
GLY A 250
 H8H  A 401 (-3.3A)
None
H8H  A 401 (-3.5A)
H8H  A 401 (-4.3A)
None
None
None
 0.65A 1uwhA-5vcxA:
22.7		 1uwhA-5vcxA:
24.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWH_A_BAXA1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 5vcx MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE
(Homo
sapiens) 		6 / 12 ALA A 137
THR A 187
LEU A 224
HIS A 231
GLY A 250
PHE A 240
 H8H  A 401 (-3.3A)
H8H  A 401 (-3.5A)
None
None
None
H8H  A 401 (-4.3A)
 1.33A 1uwhA-5vcxA:
22.7		 1uwhA-5vcxA:
24.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWH_B_BAXB1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 5vcx MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE
(Homo
sapiens) 		7 / 12 ALA A 137
GLU A 157
THR A 187
CYH A 190
LEU A 224
HIS A 231
GLY A 250
 H8H  A 401 (-3.3A)
None
H8H  A 401 (-3.5A)
H8H  A 401 (-4.3A)
None
None
None
 0.65A 1uwhB-5vcxA:
22.6		 1uwhB-5vcxA:
24.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWJ_A_BAXA1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 5vcx MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE
(Homo
sapiens) 		8 / 12 VAL A 124
ALA A 137
GLU A 157
THR A 187
CYH A 190
LEU A 224
HIS A 231
GLY A 250
 H8H  A 401 (-4.7A)
H8H  A 401 (-3.3A)
None
H8H  A 401 (-3.5A)
H8H  A 401 (-4.3A)
None
None
None
 0.66A 1uwjA-5vcxA:
6.9		 1uwjA-5vcxA:
24.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWJ_B_BAXB1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 5vcx MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE
(Homo
sapiens) 		8 / 12 VAL A 124
ALA A 137
GLU A 157
THR A 187
CYH A 190
LEU A 224
HIS A 231
GLY A 250
 H8H  A 401 (-4.7A)
H8H  A 401 (-3.3A)
None
H8H  A 401 (-3.5A)
H8H  A 401 (-4.3A)
None
None
None
 0.66A 1uwjB-5vcxA:
5.6		 1uwjB-5vcxA:
24.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XBB_A_STIA1_1
(TYROSINE-PROTEIN
KINASE SYK)		 2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Homo
sapiens) 		5 / 9 LEU A 273
VAL A 281
ALA A 293
GLY A 344
LEU A 393
 H8H  A 534 (-3.8A)
H8H  A 534 (-4.4A)
H8H  A 534 (-3.2A)
H8H  A 534 (-3.3A)
H8H  A 534 (-4.5A)
 0.36A 1xbbA-2h8hA:
30.6		 1xbbA-2h8hA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XKK_A_FMMA91_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Homo
sapiens) 		9 / 12 ALA A 293
MET A 314
THR A 338
GLY A 344
LEU A 347
ASP A 348
LEU A 393
ASP A 404
PHE A 405
 H8H  A 534 (-3.2A)
None
H8H  A 534 (-3.1A)
H8H  A 534 (-3.3A)
None
None
H8H  A 534 (-4.5A)
H8H  A 534 (-4.2A)
None
 0.89A 1xkkA-2h8hA:
33.3		 1xkkA-2h8hA:
23.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XKK_A_FMMA91_2
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Homo
sapiens) 		6 / 9 LEU A 273
VAL A 281
LYS A 295
LEU A 325
MET A 341
LEU A 407
 H8H  A 534 (-3.8A)
H8H  A 534 (-4.4A)
H8H  A 534 (-3.7A)
None
None
None
 0.58A 1xkkA-2h8hA:
33.3		 1xkkA-2h8hA:
23.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XKK_A_FMMA91_2
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 5vcx MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE
(Homo
sapiens) 		5 / 9 LEU A 116
VAL A 124
LEU A 173
LEU A 185
LEU A 189
 H8H  A 401 (-3.7A)
H8H  A 401 (-4.7A)
None
H8H  A 401 (-4.3A)
None
 0.76A 1xkkA-5vcxA:
22.7		 1xkkA-5vcxA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EVA_A_ADNA498_1
(TAK1 KINASE - TAB1
CHIMERA FUSION
PROTEIN)		 2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Homo
sapiens) 		6 / 11 GLY A 274
VAL A 281
ALA A 293
TYR A 340
SER A 345
LEU A 393
 H8H  A 534 ( 3.8A)
H8H  A 534 (-4.4A)
H8H  A 534 (-3.2A)
H8H  A 534 (-4.3A)
H8H  A 534 ( 4.5A)
H8H  A 534 (-4.5A)
 0.54A 2evaA-2h8hA:
27.1		 2evaA-2h8hA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_A_MIXA539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Homo
sapiens) 		7 / 12 LEU A 273
GLY A 274
VAL A 281
ALA A 293
ASP A 386
ALA A 390
ASN A 391
 H8H  A 534 (-3.8A)
H8H  A 534 ( 3.8A)
H8H  A 534 (-4.4A)
H8H  A 534 (-3.2A)
None
None
H8H  A 534 ( 4.9A)
 0.96A 2fumA-2h8hA:
25.0		 2fumA-2h8hA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_A_MIXA539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Homo
sapiens) 		7 / 12 LEU A 273
VAL A 281
ALA A 293
ASP A 386
ALA A 390
ASN A 391
ASP A 404
 H8H  A 534 (-3.8A)
H8H  A 534 (-4.4A)
H8H  A 534 (-3.2A)
None
None
H8H  A 534 ( 4.9A)
H8H  A 534 (-4.2A)
 0.91A 2fumA-2h8hA:
25.0		 2fumA-2h8hA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_A_MIXA539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 5vcx MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE
(Homo
sapiens) 		8 / 12 LEU A 116
VAL A 124
ALA A 137
ASP A 233
LYS A 235
ALA A 237
ASN A 238
ASP A 251
 H8H  A 401 (-3.7A)
H8H  A 401 (-4.7A)
H8H  A 401 (-3.3A)
None
EDO  A 402 (-3.4A)
H8H  A 401 ( 4.4A)
EDO  A 402 (-3.9A)
EDO  A 402 ( 2.9A)
 0.87A 2fumA-5vcxA:
20.8		 2fumA-5vcxA:
28.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_C_MIXC2539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Homo
sapiens) 		6 / 12 LEU A 273
GLY A 274
VAL A 281
ALA A 293
TYR A 340
ASN A 391
 H8H  A 534 (-3.8A)
H8H  A 534 ( 3.8A)
H8H  A 534 (-4.4A)
H8H  A 534 (-3.2A)
H8H  A 534 (-4.3A)
H8H  A 534 ( 4.9A)
 0.83A 2fumC-2h8hA:
24.6		 2fumC-2h8hA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GQG_A_1N1A501_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Homo
sapiens) 		8 / 12 ALA A 293
LYS A 295
VAL A 323
ILE A 336
THR A 338
GLY A 344
LEU A 393
ALA A 403
 H8H  A 534 (-3.2A)
H8H  A 534 (-3.7A)
None
H8H  A 534 ( 4.5A)
H8H  A 534 (-3.1A)
H8H  A 534 (-3.3A)
H8H  A 534 (-4.5A)
H8H  A 534 ( 4.0A)
 0.61A 2gqgA-2h8hA:
30.9		 2gqgA-2h8hA:
28.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GQG_A_1N1A501_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Homo
sapiens) 		8 / 12 LEU A 273
ALA A 293
VAL A 323
ILE A 336
THR A 338
GLY A 344
LEU A 393
ALA A 403
 H8H  A 534 (-3.8A)
H8H  A 534 (-3.2A)
None
H8H  A 534 ( 4.5A)
H8H  A 534 (-3.1A)
H8H  A 534 (-3.3A)
H8H  A 534 (-4.5A)
H8H  A 534 ( 4.0A)
 0.53A 2gqgA-2h8hA:
30.9		 2gqgA-2h8hA:
28.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GQG_B_1N1B502_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Homo
sapiens) 		9 / 12 LEU A 273
VAL A 281
ALA A 293
VAL A 323
ILE A 336
THR A 338
GLY A 344
LEU A 393
ALA A 403
 H8H  A 534 (-3.8A)
H8H  A 534 (-4.4A)
H8H  A 534 (-3.2A)
None
H8H  A 534 ( 4.5A)
H8H  A 534 (-3.1A)
H8H  A 534 (-3.3A)
H8H  A 534 (-4.5A)
H8H  A 534 ( 4.0A)
 0.49A 2gqgB-2h8hA:
31.1		 2gqgB-2h8hA:
28.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_A_STIA600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Homo
sapiens) 		4 / 6 LEU A 273
LYS A 295
VAL A 323
ILE A 336
 H8H  A 534 (-3.8A)
H8H  A 534 (-3.7A)
None
H8H  A 534 ( 4.5A)
 0.93A 2hyyA-2h8hA:
30.9		 2hyyA-2h8hA:
27.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_B_STIB600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Homo
sapiens) 		6 / 12 VAL A 281
ALA A 293
THR A 338
GLY A 344
LEU A 393
ALA A 403
 H8H  A 534 (-4.4A)
H8H  A 534 (-3.2A)
H8H  A 534 (-3.1A)
H8H  A 534 (-3.3A)
H8H  A 534 (-4.5A)
H8H  A 534 ( 4.0A)
 0.78A 2hyyB-2h8hA:
30.8		 2hyyB-2h8hA:
27.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_C_STIC600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Homo
sapiens) 		7 / 12 VAL A 281
ALA A 293
VAL A 323
THR A 338
GLY A 344
LEU A 393
ALA A 403
 H8H  A 534 (-4.4A)
H8H  A 534 (-3.2A)
None
H8H  A 534 (-3.1A)
H8H  A 534 (-3.3A)
H8H  A 534 (-4.5A)
H8H  A 534 ( 4.0A)
 0.81A 2hyyC-2h8hA:
31.0		 2hyyC-2h8hA:
27.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_D_STID600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Homo
sapiens) 		6 / 12 VAL A 281
ALA A 293
ILE A 336
THR A 338
LEU A 393
ALA A 403
 H8H  A 534 (-4.4A)
H8H  A 534 (-3.2A)
H8H  A 534 ( 4.5A)
H8H  A 534 (-3.1A)
H8H  A 534 (-4.5A)
H8H  A 534 ( 4.0A)
 0.85A 2hyyD-2h8hA:
30.7		 2hyyD-2h8hA:
27.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ITO_A_IREA2020_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Homo
sapiens) 		7 / 12 LEU A 273
ALA A 293
LYS A 295
THR A 338
GLY A 344
ASP A 348
LEU A 393
 H8H  A 534 (-3.8A)
H8H  A 534 (-3.2A)
H8H  A 534 (-3.7A)
H8H  A 534 (-3.1A)
H8H  A 534 (-3.3A)
None
H8H  A 534 (-4.5A)
 0.56A 2itoA-2h8hA:
29.3		 2itoA-2h8hA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ITY_A_IREA2020_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Homo
sapiens) 		9 / 12 LEU A 273
GLY A 274
VAL A 281
ALA A 293
LYS A 295
THR A 338
GLY A 344
LEU A 393
ASP A 404
 H8H  A 534 (-3.8A)
H8H  A 534 ( 3.8A)
H8H  A 534 (-4.4A)
H8H  A 534 (-3.2A)
H8H  A 534 (-3.7A)
H8H  A 534 (-3.1A)
H8H  A 534 (-3.3A)
H8H  A 534 (-4.5A)
H8H  A 534 (-4.2A)
 0.79A 2ityA-2h8hA:
29.6		 2ityA-2h8hA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ITZ_A_IREA2021_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Homo
sapiens) 		8 / 12 LEU A 273
VAL A 281
ALA A 293
LYS A 295
THR A 338
GLY A 344
ASP A 348
LEU A 393
 H8H  A 534 (-3.8A)
H8H  A 534 (-4.4A)
H8H  A 534 (-3.2A)
H8H  A 534 (-3.7A)
H8H  A 534 (-3.1A)
H8H  A 534 (-3.3A)
None
H8H  A 534 (-4.5A)
 0.60A 2itzA-2h8hA:
29.6		 2itzA-2h8hA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ITZ_A_IREA2021_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Homo
sapiens) 		8 / 12 LEU A 273
VAL A 281
ALA A 293
LYS A 295
THR A 338
GLY A 344
LEU A 393
ASP A 404
 H8H  A 534 (-3.8A)
H8H  A 534 (-4.4A)
H8H  A 534 (-3.2A)
H8H  A 534 (-3.7A)
H8H  A 534 (-3.1A)
H8H  A 534 (-3.3A)
H8H  A 534 (-4.5A)
H8H  A 534 (-4.2A)
 0.75A 2itzA-2h8hA:
29.6		 2itzA-2h8hA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IVU_A_ZD6A3015_0
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
PRECURSOR)		 2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Homo
sapiens) 		6 / 12 LEU A 273
GLY A 274
VAL A 281
LYS A 295
TYR A 340
LEU A 393
 H8H  A 534 (-3.8A)
H8H  A 534 ( 3.8A)
H8H  A 534 (-4.4A)
H8H  A 534 (-3.7A)
H8H  A 534 (-4.3A)
H8H  A 534 (-4.5A)
 0.52A 2ivuA-2h8hA:
30.8		 2ivuA-2h8hA:
24.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OIQ_A_STIA1001_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Homo
sapiens) 		7 / 12 VAL A 281
ALA A 293
ILE A 336
THR A 338
TYR A 340
GLY A 344
LEU A 393
 H8H  A 534 (-4.4A)
H8H  A 534 (-3.2A)
H8H  A 534 ( 4.5A)
H8H  A 534 (-3.1A)
H8H  A 534 (-4.3A)
H8H  A 534 (-3.3A)
H8H  A 534 (-4.5A)
 0.75A 2oiqA-2h8hA:
33.8		 2oiqA-2h8hA:
52.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OIQ_A_STIA1001_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Homo
sapiens) 		7 / 12 VAL A 281
ALA A 293
THR A 338
TYR A 340
GLY A 344
LEU A 393
ALA A 403
 H8H  A 534 (-4.4A)
H8H  A 534 (-3.2A)
H8H  A 534 (-3.1A)
H8H  A 534 (-4.3A)
H8H  A 534 (-3.3A)
H8H  A 534 (-4.5A)
H8H  A 534 ( 4.0A)
 0.65A 2oiqA-2h8hA:
33.8		 2oiqA-2h8hA:
52.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OIQ_A_STIA1001_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Homo
sapiens) 		4 / 5 LEU A 273
LEU A 317
MET A 341
ARG A 385
 H8H  A 534 (-3.8A)
None
None
None
 0.75A 2oiqA-2h8hA:
33.8		 2oiqA-2h8hA:
52.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2PL0_A_STIA200_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE LCK)		 2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Homo
sapiens) 		7 / 12 VAL A 281
ALA A 293
LYS A 295
VAL A 323
ILE A 336
THR A 338
TYR A 340
 H8H  A 534 (-4.4A)
H8H  A 534 (-3.2A)
H8H  A 534 (-3.7A)
None
H8H  A 534 ( 4.5A)
H8H  A 534 (-3.1A)
H8H  A 534 (-4.3A)
 0.74A 2pl0A-2h8hA:
31.7		 2pl0A-2h8hA:
36.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2PL0_A_STIA200_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE LCK)		 2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Homo
sapiens) 		7 / 12 VAL A 281
ALA A 293
VAL A 323
ILE A 336
THR A 338
TYR A 340
ALA A 403
 H8H  A 534 (-4.4A)
H8H  A 534 (-3.2A)
None
H8H  A 534 ( 4.5A)
H8H  A 534 (-3.1A)
H8H  A 534 (-4.3A)
H8H  A 534 ( 4.0A)
 0.91A 2pl0A-2h8hA:
31.7		 2pl0A-2h8hA:
36.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WGJ_A_VGHA2346_1
(HEPATOCYTE GROWTH
FACTOR RECEPTOR)		 2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Homo
sapiens) 		8 / 12 GLY A 274
VAL A 281
ALA A 293
TYR A 340
MET A 341
GLY A 344
ALA A 403
ASP A 404
 H8H  A 534 ( 3.8A)
H8H  A 534 (-4.4A)
H8H  A 534 (-3.2A)
H8H  A 534 (-4.3A)
None
H8H  A 534 (-3.3A)
H8H  A 534 ( 4.0A)
H8H  A 534 (-4.2A)
 0.97A 2wgjA-2h8hA:
30.5		 2wgjA-2h8hA:
24.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XP2_A_VGHA9000_1
(TYROSINE-PROTEIN
KINASE RECEPTOR)		 2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Homo
sapiens) 		7 / 9 LEU A 273
VAL A 281
ALA A 293
MET A 341
GLY A 344
LEU A 393
ASP A 404
 H8H  A 534 (-3.8A)
H8H  A 534 (-4.4A)
H8H  A 534 (-3.2A)
None
H8H  A 534 (-3.3A)
H8H  A 534 (-4.5A)
H8H  A 534 (-4.2A)
 0.67A 2xp2A-2h8hA:
30.0		 2xp2A-2h8hA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6O_A_1N1A1892_1
(EPHRIN TYPE-A
RECEPTOR 4)		 2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Homo
sapiens) 		7 / 12 ALA A 293
LYS A 295
ILE A 336
THR A 338
TYR A 340
GLY A 344
LEU A 393
 H8H  A 534 (-3.2A)
H8H  A 534 (-3.7A)
H8H  A 534 ( 4.5A)
H8H  A 534 (-3.1A)
H8H  A 534 (-4.3A)
H8H  A 534 (-3.3A)
H8H  A 534 (-4.5A)
 0.51A 2y6oA-2h8hA:
30.6		 2y6oA-2h8hA:
25.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7J_C_B49C1294_1
(PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM)		 2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Homo
sapiens) 		6 / 10 VAL A 281
ALA A 293
MET A 341
GLY A 344
ASP A 348
LEU A 393
 H8H  A 534 (-4.4A)
H8H  A 534 (-3.2A)
None
H8H  A 534 (-3.3A)
None
H8H  A 534 (-4.5A)
 0.37A 2y7jC-2h8hA:
24.4		 2y7jC-2h8hA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7J_D_B49D1294_1
(PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM)		 2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Homo
sapiens) 		6 / 10 VAL A 281
ALA A 293
MET A 341
GLY A 344
ASP A 348
LEU A 393
 H8H  A 534 (-4.4A)
H8H  A 534 (-3.2A)
None
H8H  A 534 (-3.3A)
None
H8H  A 534 (-4.5A)
 0.25A 2y7jD-2h8hA:
24.4		 2y7jD-2h8hA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YFX_A_VGHA9000_1
(TYROSINE-PROTEIN
KINASE RECEPTOR)		 2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Homo
sapiens) 		6 / 8 LEU A 273
ALA A 293
MET A 341
GLY A 344
LEU A 393
ASP A 404
 H8H  A 534 (-3.8A)
H8H  A 534 (-3.2A)
None
H8H  A 534 (-3.3A)
H8H  A 534 (-4.5A)
H8H  A 534 (-4.2A)
 0.67A 2yfxA-2h8hA:
29.8		 2yfxA-2h8hA:
22.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ZVA_A_1N1A513_1
(TYROSINE-PROTEIN
KINASE LYN)		 2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Homo
sapiens) 		10 / 12 LEU A 273
ALA A 293
LYS A 295
VAL A 323
ILE A 336
THR A 338
MET A 341
GLY A 344
LEU A 393
ALA A 403
 H8H  A 534 (-3.8A)
H8H  A 534 (-3.2A)
H8H  A 534 (-3.7A)
None
H8H  A 534 ( 4.5A)
H8H  A 534 (-3.1A)
None
H8H  A 534 (-3.3A)
H8H  A 534 (-4.5A)
H8H  A 534 ( 4.0A)
 0.62A 2zvaA-2h8hA:
33.9		 2zvaA-2h8hA:
34.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AOX_A_EMHA901_1
(ALK TYROSINE KINASE
RECEPTOR)		 2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Homo
sapiens) 		7 / 10 LEU A 273
ALA A 293
LYS A 295
VAL A 323
MET A 341
GLY A 344
LEU A 393
 H8H  A 534 (-3.8A)
H8H  A 534 (-3.2A)
H8H  A 534 (-3.7A)
None
None
H8H  A 534 (-3.3A)
H8H  A 534 (-4.5A)
 0.72A 3aoxA-2h8hA:
29.1		 3aoxA-2h8hA:
25.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BBT_B_FMMB91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		 2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Homo
sapiens) 		10 / 12 VAL A 281
ALA A 293
MET A 314
LEU A 325
THR A 338
GLY A 344
LEU A 393
ASP A 404
PHE A 405
LEU A 407
 H8H  A 534 (-4.4A)
H8H  A 534 (-3.2A)
None
None
H8H  A 534 (-3.1A)
H8H  A 534 (-3.3A)
H8H  A 534 (-4.5A)
H8H  A 534 (-4.2A)
None
None
 0.84A 3bbtB-2h8hA:
32.9		 3bbtB-2h8hA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BBT_B_FMMB91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		 5vcx MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE
(Homo
sapiens) 		8 / 12 VAL A 124
ALA A 137
LEU A 173
THR A 187
LEU A 189
GLY A 191
ASP A 251
PHE A 252
 H8H  A 401 (-4.7A)
H8H  A 401 (-3.3A)
None
H8H  A 401 (-3.5A)
None
H8H  A 401 (-4.4A)
EDO  A 402 ( 2.9A)
None
 1.29A 3bbtB-5vcxA:
17.3		 3bbtB-5vcxA:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BBT_D_FMMD91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		 2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Homo
sapiens) 		9 / 12 VAL A 281
ALA A 293
LYS A 295
MET A 314
THR A 338
GLY A 344
LEU A 393
ASP A 404
LEU A 407
 H8H  A 534 (-4.4A)
H8H  A 534 (-3.2A)
H8H  A 534 (-3.7A)
None
H8H  A 534 (-3.1A)
H8H  A 534 (-3.3A)
H8H  A 534 (-4.5A)
H8H  A 534 (-4.2A)
None
 0.93A 3bbtD-2h8hA:
32.7		 3bbtD-2h8hA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BBT_D_FMMD91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		 2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Homo
sapiens) 		9 / 12 VAL A 281
ALA A 293
LYS A 295
THR A 338
GLY A 344
LEU A 393
ASP A 404
PHE A 405
LEU A 407
 H8H  A 534 (-4.4A)
H8H  A 534 (-3.2A)
H8H  A 534 (-3.7A)
H8H  A 534 (-3.1A)
H8H  A 534 (-3.3A)
H8H  A 534 (-4.5A)
H8H  A 534 (-4.2A)
None
None
 0.89A 3bbtD-2h8hA:
32.7		 3bbtD-2h8hA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS9_A_NILA600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Homo
sapiens) 		5 / 10 LEU A 273
VAL A 281
LYS A 295
VAL A 323
ILE A 336
 H8H  A 534 (-3.8A)
H8H  A 534 (-4.4A)
H8H  A 534 (-3.7A)
None
H8H  A 534 ( 4.5A)
 0.70A 3cs9A-2h8hA:
30.7		 3cs9A-2h8hA:
27.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS9_A_NILA600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Homo
sapiens) 		5 / 10 LEU A 273
VAL A 281
VAL A 323
ILE A 336
VAL A 402
 H8H  A 534 (-3.8A)
H8H  A 534 (-4.4A)
None
H8H  A 534 ( 4.5A)
None
 0.85A 3cs9A-2h8hA:
30.7		 3cs9A-2h8hA:
27.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS9_A_NILA600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Homo
sapiens) 		7 / 12 ALA A 293
LEU A 322
THR A 338
GLY A 344
HIS A 384
LEU A 393
ALA A 403
 H8H  A 534 (-3.2A)
None
H8H  A 534 (-3.1A)
H8H  A 534 (-3.3A)
None
H8H  A 534 (-4.5A)
H8H  A 534 ( 4.0A)
 0.59A 3cs9A-2h8hA:
30.7		 3cs9A-2h8hA:
27.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS9_B_NILB600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Homo
sapiens) 		5 / 12 ALA A 293
LEU A 322
GLY A 344
HIS A 384
ALA A 403
 H8H  A 534 (-3.2A)
None
H8H  A 534 (-3.3A)
None
H8H  A 534 ( 4.0A)
 0.58A 3cs9B-2h8hA:
30.6		 3cs9B-2h8hA:
27.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS9_B_NILB600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Homo
sapiens) 		5 / 12 ALA A 293
LEU A 322
THR A 338
GLY A 344
ALA A 403
 H8H  A 534 (-3.2A)
None
H8H  A 534 (-3.1A)
H8H  A 534 (-3.3A)
H8H  A 534 ( 4.0A)
 0.46A 3cs9B-2h8hA:
30.6		 3cs9B-2h8hA:
27.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS9_B_NILB600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Homo
sapiens) 		5 / 9 LEU A 273
VAL A 281
LYS A 295
VAL A 323
ILE A 336
 H8H  A 534 (-3.8A)
H8H  A 534 (-4.4A)
H8H  A 534 (-3.7A)
None
H8H  A 534 ( 4.5A)
 0.70A 3cs9B-2h8hA:
30.6		 3cs9B-2h8hA:
27.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS9_B_NILB600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Homo
sapiens) 		6 / 9 LEU A 273
VAL A 281
VAL A 323
ILE A 336
LEU A 393
VAL A 402
 H8H  A 534 (-3.8A)
H8H  A 534 (-4.4A)
None
H8H  A 534 ( 4.5A)
H8H  A 534 (-4.5A)
None
 0.97A 3cs9B-2h8hA:
30.6		 3cs9B-2h8hA:
27.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS9_C_NILC600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Homo
sapiens) 		5 / 12 ALA A 293
LEU A 322
THR A 338
HIS A 384
ALA A 403
 H8H  A 534 (-3.2A)
None
H8H  A 534 (-3.1A)
None
H8H  A 534 ( 4.0A)
 0.66A 3cs9C-2h8hA:
30.2		 3cs9C-2h8hA:
27.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS9_C_NILC600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Homo
sapiens) 		5 / 9 LEU A 273
VAL A 281
ILE A 336
MET A 341
VAL A 402
 H8H  A 534 (-3.8A)
H8H  A 534 (-4.4A)
H8H  A 534 ( 4.5A)
None
None
 0.74A 3cs9C-2h8hA:
30.2		 3cs9C-2h8hA:
27.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS9_C_NILC600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Homo
sapiens) 		5 / 9 LEU A 273
VAL A 281
LYS A 295
VAL A 323
ILE A 336
 H8H  A 534 (-3.8A)
H8H  A 534 (-4.4A)
H8H  A 534 (-3.7A)
None
H8H  A 534 ( 4.5A)
 0.67A 3cs9C-2h8hA:
30.2		 3cs9C-2h8hA:
27.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS9_C_NILC600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Homo
sapiens) 		5 / 9 LEU A 273
VAL A 281
VAL A 323
ILE A 336
VAL A 402
 H8H  A 534 (-3.8A)
H8H  A 534 (-4.4A)
None
H8H  A 534 ( 4.5A)
None
 0.88A 3cs9C-2h8hA:
30.2		 3cs9C-2h8hA:
27.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS9_D_NILD600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Homo
sapiens) 		6 / 12 ALA A 293
LEU A 322
THR A 338
GLY A 344
HIS A 384
ALA A 403
 H8H  A 534 (-3.2A)
None
H8H  A 534 (-3.1A)
H8H  A 534 (-3.3A)
None
H8H  A 534 ( 4.0A)
 0.50A 3cs9D-2h8hA:
29.5		 3cs9D-2h8hA:
27.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EYG_A_MI1A1_1
(TYROSINE-PROTEIN
KINASE)		 2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Homo
sapiens) 		9 / 12 LEU A 273
GLY A 274
GLY A 279
VAL A 281
ALA A 293
LYS A 295
SER A 345
ASN A 391
LEU A 393
 H8H  A 534 (-3.8A)
H8H  A 534 ( 3.8A)
None
H8H  A 534 (-4.4A)
H8H  A 534 (-3.2A)
H8H  A 534 (-3.7A)
H8H  A 534 ( 4.5A)
H8H  A 534 ( 4.9A)
H8H  A 534 (-4.5A)
 0.93A 3eygA-2h8hA:
28.8		 3eygA-2h8hA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FUP_A_MI1A1_1
(TYROSINE-PROTEIN
KINASE JAK2)		 2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Homo
sapiens) 		8 / 12 LEU A 273
GLY A 274
GLY A 276
GLY A 279
VAL A 281
ALA A 293
LYS A 295
TYR A 340
 H8H  A 534 (-3.8A)
H8H  A 534 ( 3.8A)
None
None
H8H  A 534 (-4.4A)
H8H  A 534 (-3.2A)
H8H  A 534 (-3.7A)
H8H  A 534 (-4.3A)
 0.81A 3fupA-2h8hA:
29.3		 3fupA-2h8hA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FUP_A_MI1A1_1
(TYROSINE-PROTEIN
KINASE JAK2)		 2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Homo
sapiens) 		8 / 12 LEU A 273
GLY A 274
GLY A 279
VAL A 281
ALA A 293
TYR A 340
SER A 345
LEU A 393
 H8H  A 534 (-3.8A)
H8H  A 534 ( 3.8A)
None
H8H  A 534 (-4.4A)
H8H  A 534 (-3.2A)
H8H  A 534 (-4.3A)
H8H  A 534 ( 4.5A)
H8H  A 534 (-4.5A)
 0.72A 3fupA-2h8hA:
29.3		 3fupA-2h8hA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G0E_A_B49A9000_1
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR)		 2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Homo
sapiens) 		8 / 11 LEU A 273
VAL A 281
ALA A 293
VAL A 323
THR A 338
TYR A 340
GLY A 344
LEU A 393
 H8H  A 534 (-3.8A)
H8H  A 534 (-4.4A)
H8H  A 534 (-3.2A)
None
H8H  A 534 (-3.1A)
H8H  A 534 (-4.3A)
H8H  A 534 (-3.3A)
H8H  A 534 (-4.5A)
 0.75A 3g0eA-2h8hA:
27.7		 3g0eA-2h8hA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G0F_A_B49A9001_1
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR)		 2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Homo
sapiens) 		7 / 11 LEU A 273
VAL A 281
ALA A 293
THR A 338
TYR A 340
GLY A 344
LEU A 393
 H8H  A 534 (-3.8A)
H8H  A 534 (-4.4A)
H8H  A 534 (-3.2A)
H8H  A 534 (-3.1A)
H8H  A 534 (-4.3A)
H8H  A 534 (-3.3A)
H8H  A 534 (-4.5A)
 0.75A 3g0fA-2h8hA:
28.1		 3g0fA-2h8hA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G0F_B_B49B9001_1
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR)		 2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Homo
sapiens) 		7 / 10 LEU A 273
VAL A 281
ALA A 293
THR A 338
TYR A 340
GLY A 344
LEU A 393
 H8H  A 534 (-3.8A)
H8H  A 534 (-4.4A)
H8H  A 534 (-3.2A)
H8H  A 534 (-3.1A)
H8H  A 534 (-4.3A)
H8H  A 534 (-3.3A)
H8H  A 534 (-4.5A)
 0.62A 3g0fB-2h8hA:
28.5		 3g0fB-2h8hA:
22.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G5D_A_1N1A1_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Homo
sapiens) 		10 / 12 LEU A 273
VAL A 281
ALA A 293
VAL A 323
ILE A 336
THR A 338
TYR A 340
GLY A 344
LEU A 393
ALA A 403
 H8H  A 534 (-3.8A)
H8H  A 534 (-4.4A)
H8H  A 534 (-3.2A)
None
H8H  A 534 ( 4.5A)
H8H  A 534 (-3.1A)
H8H  A 534 (-4.3A)
H8H  A 534 (-3.3A)
H8H  A 534 (-4.5A)
H8H  A 534 ( 4.0A)
 0.49A 3g5dA-2h8hA:
34.1		 3g5dA-2h8hA:
52.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G5D_B_1N1B1_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Homo
sapiens) 		10 / 12 LEU A 273
VAL A 281
ALA A 293
LYS A 295
VAL A 323
THR A 338
TYR A 340
GLY A 344
LEU A 393
ALA A 403
 H8H  A 534 (-3.8A)
H8H  A 534 (-4.4A)
H8H  A 534 (-3.2A)
H8H  A 534 (-3.7A)
None
H8H  A 534 (-3.1A)
H8H  A 534 (-4.3A)
H8H  A 534 (-3.3A)
H8H  A 534 (-4.5A)
H8H  A 534 ( 4.0A)
 0.60A 3g5dB-2h8hA:
34.1		 3g5dB-2h8hA:
52.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GVU_A_STIA1001_1
(TYROSINE-PROTEIN
KINASE ABL2)		 2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Homo
sapiens) 		7 / 12 LEU A 273
VAL A 281
ALA A 293
VAL A 323
THR A 338
LEU A 393
ALA A 403
 H8H  A 534 (-3.8A)
H8H  A 534 (-4.4A)
H8H  A 534 (-3.2A)
None
H8H  A 534 (-3.1A)
H8H  A 534 (-4.5A)
H8H  A 534 ( 4.0A)
 0.74A 3gvuA-2h8hA:
30.5		 3gvuA-2h8hA:
29.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GVU_A_STIA1001_1
(TYROSINE-PROTEIN
KINASE ABL2)		 5vcx MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE
(Homo
sapiens) 		6 / 12 LEU A 116
VAL A 124
ALA A 137
GLU A 157
VAL A 171
THR A 187
 H8H  A 401 (-3.7A)
H8H  A 401 (-4.7A)
H8H  A 401 (-3.3A)
None
None
H8H  A 401 (-3.5A)
 0.55A 3gvuA-5vcxA:
18.3		 3gvuA-5vcxA:
28.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HEC_A_STIA1_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 5vcx MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE
(Homo
sapiens) 		5 / 12 ALA A 137
LYS A 139
GLU A 157
THR A 187
LEU A 189
 H8H  A 401 (-3.3A)
H8H  A 401 (-4.9A)
None
H8H  A 401 (-3.5A)
None
 0.79A 3hecA-5vcxA:
18.1		 3hecA-5vcxA:
24.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IK3_A_0LIA1_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Homo
sapiens) 		6 / 12 ALA A 293
LEU A 322
VAL A 323
HIS A 384
LEU A 393
ALA A 403
 H8H  A 534 (-3.2A)
None
None
None
H8H  A 534 (-4.5A)
H8H  A 534 ( 4.0A)
 0.77A 3ik3A-2h8hA:
30.6		 3ik3A-2h8hA:
27.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IK3_B_0LIB2_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Homo
sapiens) 		6 / 12 ALA A 293
LEU A 322
VAL A 323
HIS A 384
LEU A 393
ALA A 403
 H8H  A 534 (-3.2A)
None
None
None
H8H  A 534 (-4.5A)
H8H  A 534 ( 4.0A)
 0.83A 3ik3B-2h8hA:
30.2		 3ik3B-2h8hA:
27.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K54_A_1N1A1_1
(TYROSINE-PROTEIN
KINASE BTK)		 2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Homo
sapiens) 		9 / 12 LEU A 273
ALA A 293
LYS A 295
VAL A 323
ILE A 336
THR A 338
TYR A 340
GLY A 344
LEU A 393
 H8H  A 534 (-3.8A)
H8H  A 534 (-3.2A)
H8H  A 534 (-3.7A)
None
H8H  A 534 ( 4.5A)
H8H  A 534 (-3.1A)
H8H  A 534 (-4.3A)
H8H  A 534 (-3.3A)
H8H  A 534 (-4.5A)
 0.53A 3k54A-2h8hA:
30.2		 3k54A-2h8hA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K5V_A_STIA2_2
(TYROSINE-PROTEIN
KINASE ABL1)		 2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Homo
sapiens) 		4 / 6 LEU A 273
LYS A 295
VAL A 323
ILE A 336
 H8H  A 534 (-3.8A)
H8H  A 534 (-3.7A)
None
H8H  A 534 ( 4.5A)
 0.78A 3k5vA-2h8hA:
29.7		 3k5vA-2h8hA:
28.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K5V_B_STIB2_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Homo
sapiens) 		6 / 12 VAL A 281
ALA A 293
THR A 338
GLY A 344
LEU A 393
ALA A 403
 H8H  A 534 (-4.4A)
H8H  A 534 (-3.2A)
H8H  A 534 (-3.1A)
H8H  A 534 (-3.3A)
H8H  A 534 (-4.5A)
H8H  A 534 ( 4.0A)
 0.77A 3k5vB-2h8hA:
29.9		 3k5vB-2h8hA:
28.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K5V_B_STIB2_2
(TYROSINE-PROTEIN
KINASE ABL1)		 2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Homo
sapiens) 		4 / 6 LEU A 273
LYS A 295
VAL A 323
ILE A 336
 H8H  A 534 (-3.8A)
H8H  A 534 (-3.7A)
None
H8H  A 534 ( 4.5A)
 0.83A 3k5vB-2h8hA:
30.0		 3k5vB-2h8hA:
28.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LFA_A_1N1A361_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 5vcx MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE
(Homo
sapiens) 		5 / 8 ALA A 137
LYS A 139
GLU A 157
LEU A 185
LEU A 189
 H8H  A 401 (-3.3A)
H8H  A 401 (-4.9A)
None
H8H  A 401 (-4.3A)
None
 1.07A 3lfaA-5vcxA:
22.1		 3lfaA-5vcxA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LFA_A_1N1A361_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 5vcx MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE
(Homo
sapiens) 		5 / 8 ALA A 137
LYS A 139
GLU A 157
THR A 187
LEU A 189
 H8H  A 401 (-3.3A)
H8H  A 401 (-4.9A)
None
H8H  A 401 (-3.5A)
None
 0.83A 3lfaA-5vcxA:
22.1		 3lfaA-5vcxA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LXN_A_MI1A1_1
(NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2)		 2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Homo
sapiens) 		7 / 12 LEU A 273
GLY A 274
VAL A 281
ALA A 293
TYR A 340
SER A 345
LEU A 393
 H8H  A 534 (-3.8A)
H8H  A 534 ( 3.8A)
H8H  A 534 (-4.4A)
H8H  A 534 (-3.2A)
H8H  A 534 (-4.3A)
H8H  A 534 ( 4.5A)
H8H  A 534 (-4.5A)
 0.57A 3lxnA-2h8hA:
28.4		 3lxnA-2h8hA:
24.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MIY_B_B49B2_1
(TYROSINE-PROTEIN
KINASE ITK/TSK)		 2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Homo
sapiens) 		5 / 9 ALA A 293
LYS A 295
MET A 341
GLY A 344
LEU A 393
 H8H  A 534 (-3.2A)
H8H  A 534 (-3.7A)
None
H8H  A 534 (-3.3A)
H8H  A 534 (-4.5A)
 0.52A 3miyB-2h8hA:
31.3		 3miyB-2h8hA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MS9_A_STIA1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Homo
sapiens) 		6 / 12 LEU A 273
VAL A 281
ALA A 293
THR A 338
LEU A 393
ALA A 403
 H8H  A 534 (-3.8A)
H8H  A 534 (-4.4A)
H8H  A 534 (-3.2A)
H8H  A 534 (-3.1A)
H8H  A 534 (-4.5A)
H8H  A 534 ( 4.0A)
 0.74A 3ms9A-2h8hA:
30.1		 3ms9A-2h8hA:
28.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MS9_B_STIB1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Homo
sapiens) 		7 / 12 LEU A 273
VAL A 281
ALA A 293
THR A 338
GLY A 344
LEU A 393
ALA A 403
 H8H  A 534 (-3.8A)
H8H  A 534 (-4.4A)
H8H  A 534 (-3.2A)
H8H  A 534 (-3.1A)
H8H  A 534 (-3.3A)
H8H  A 534 (-4.5A)
H8H  A 534 ( 4.0A)
 0.77A 3ms9B-2h8hA:
30.2		 3ms9B-2h8hA:
28.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_A_STIA1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Homo
sapiens) 		6 / 12 LEU A 273
VAL A 281
ALA A 293
THR A 338
LEU A 393
ALA A 403
 H8H  A 534 (-3.8A)
H8H  A 534 (-4.4A)
H8H  A 534 (-3.2A)
H8H  A 534 (-3.1A)
H8H  A 534 (-4.5A)
H8H  A 534 ( 4.0A)
 0.78A 3mssA-2h8hA:
30.3		 3mssA-2h8hA:
28.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_C_STIC1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Homo
sapiens) 		6 / 12 LEU A 273
VAL A 281
ALA A 293
THR A 338
LEU A 393
ALA A 403
 H8H  A 534 (-3.8A)
H8H  A 534 (-4.4A)
H8H  A 534 (-3.2A)
H8H  A 534 (-3.1A)
H8H  A 534 (-4.5A)
H8H  A 534 ( 4.0A)
 0.78A 3mssC-2h8hA:
30.3		 3mssC-2h8hA:
28.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_D_STID1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Homo
sapiens) 		6 / 12 LEU A 273
ALA A 293
THR A 338
GLY A 344
LEU A 393
ALA A 403
 H8H  A 534 (-3.8A)
H8H  A 534 (-3.2A)
H8H  A 534 (-3.1A)
H8H  A 534 (-3.3A)
H8H  A 534 (-4.5A)
H8H  A 534 ( 4.0A)
 0.71A 3mssD-2h8hA:
30.5		 3mssD-2h8hA:
28.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_D_STID1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Homo
sapiens) 		4 / 6 VAL A 281
LYS A 295
VAL A 323
ILE A 336
 H8H  A 534 (-4.4A)
H8H  A 534 (-3.7A)
None
H8H  A 534 ( 4.5A)
 0.67A 3mssD-2h8hA:
30.5		 3mssD-2h8hA:
28.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OCT_A_1N1A663_1
(TYROSINE-PROTEIN
KINASE BTK)		 2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Homo
sapiens) 		9 / 12 LEU A 273
VAL A 281
ALA A 293
LYS A 295
VAL A 323
THR A 338
TYR A 340
GLY A 344
LEU A 393
 H8H  A 534 (-3.8A)
H8H  A 534 (-4.4A)
H8H  A 534 (-3.2A)
H8H  A 534 (-3.7A)
None
H8H  A 534 (-3.1A)
H8H  A 534 (-4.3A)
H8H  A 534 (-3.3A)
H8H  A 534 (-4.5A)
 0.52A 3octA-2h8hA:
29.9		 3octA-2h8hA:
22.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OEZ_A_STIA601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Homo
sapiens) 		7 / 12 VAL A 281
ALA A 293
THR A 338
TYR A 340
GLY A 344
LEU A 393
ALA A 403
 H8H  A 534 (-4.4A)
H8H  A 534 (-3.2A)
H8H  A 534 (-3.1A)
H8H  A 534 (-4.3A)
H8H  A 534 (-3.3A)
H8H  A 534 (-4.5A)
H8H  A 534 ( 4.0A)
 0.64A 3oezA-2h8hA:
33.6		 3oezA-2h8hA:
52.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OEZ_A_STIA601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Homo
sapiens) 		7 / 12 VAL A 281
ALA A 293
VAL A 323
THR A 338
TYR A 340
LEU A 393
ALA A 403
 H8H  A 534 (-4.4A)
H8H  A 534 (-3.2A)
None
H8H  A 534 (-3.1A)
H8H  A 534 (-4.3A)
H8H  A 534 (-4.5A)
H8H  A 534 ( 4.0A)
 0.80A 3oezA-2h8hA:
33.6		 3oezA-2h8hA:
52.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OEZ_B_STIB601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Homo
sapiens) 		8 / 12 VAL A 281
ALA A 293
LYS A 295
ILE A 336
THR A 338
TYR A 340
LEU A 393
ALA A 403
 H8H  A 534 (-4.4A)
H8H  A 534 (-3.2A)
H8H  A 534 (-3.7A)
H8H  A 534 ( 4.5A)
H8H  A 534 (-3.1A)
H8H  A 534 (-4.3A)
H8H  A 534 (-4.5A)
H8H  A 534 ( 4.0A)
 0.56A 3oezB-2h8hA:
34.4		 3oezB-2h8hA:
52.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OG7_A_032A1_1
(AKAP9-BRAF FUSION
PROTEIN)		 5vcx MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE
(Homo
sapiens) 		6 / 12 VAL A 124
ALA A 137
LYS A 139
THR A 187
CYH A 190
GLY A 253
 H8H  A 401 (-4.7A)
H8H  A 401 (-3.3A)
H8H  A 401 (-4.9A)
H8H  A 401 (-3.5A)
H8H  A 401 (-4.3A)
None
 1.13A 3og7A-5vcxA:
18.1		 3og7A-5vcxA:
25.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OG7_A_032A1_1
(AKAP9-BRAF FUSION
PROTEIN)		 5vcx MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE
(Homo
sapiens) 		6 / 12 VAL A 124
ALA A 137
THR A 187
CYH A 190
PHE A 240
GLY A 253
 H8H  A 401 (-4.7A)
H8H  A 401 (-3.3A)
H8H  A 401 (-3.5A)
H8H  A 401 (-4.3A)
H8H  A 401 (-4.3A)
None
 0.67A 3og7A-5vcxA:
18.1		 3og7A-5vcxA:
25.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OG7_A_032A1_1
(AKAP9-BRAF FUSION
PROTEIN)		 5vcx MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE
(Homo
sapiens) 		6 / 12 VAL A 124
ALA A 137
THR A 187
CYH A 190
PHE A 240
PHE A 252
 H8H  A 401 (-4.7A)
H8H  A 401 (-3.3A)
H8H  A 401 (-3.5A)
H8H  A 401 (-4.3A)
H8H  A 401 (-4.3A)
None
 0.83A 3og7A-5vcxA:
18.1		 3og7A-5vcxA:
25.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_B_1N1B1000_1
(P38A)		 5vcx MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE
(Homo
sapiens) 		5 / 12 GLY A 117
VAL A 124
ALA A 137
LYS A 139
THR A 187
 H8H  A 401 ( 3.7A)
H8H  A 401 (-4.7A)
H8H  A 401 (-3.3A)
H8H  A 401 (-4.9A)
H8H  A 401 (-3.5A)
 0.49A 3ohtB-5vcxA:
18.0		 3ohtB-5vcxA:
24.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXZ_A_0LIA1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Homo
sapiens) 		7 / 12 ALA A 293
LEU A 322
VAL A 323
THR A 338
GLY A 344
HIS A 384
ALA A 403
 H8H  A 534 (-3.2A)
None
None
H8H  A 534 (-3.1A)
H8H  A 534 (-3.3A)
None
H8H  A 534 ( 4.0A)
 0.68A 3oxzA-2h8hA:
30.8		 3oxzA-2h8hA:
27.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXZ_A_0LIA1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Homo
sapiens) 		5 / 9 LEU A 273
ILE A 336
MET A 341
LEU A 393
VAL A 402
 H8H  A 534 (-3.8A)
H8H  A 534 ( 4.5A)
None
H8H  A 534 (-4.5A)
None
 0.55A 3oxzA-2h8hA:
30.8		 3oxzA-2h8hA:
27.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXZ_A_0LIA1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Homo
sapiens) 		5 / 9 LEU A 273
MET A 341
ARG A 385
LEU A 393
VAL A 402
 H8H  A 534 (-3.8A)
None
None
H8H  A 534 (-4.5A)
None
 0.46A 3oxzA-2h8hA:
30.8		 3oxzA-2h8hA:
27.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PYY_A_STIA3_1
(V-ABL ABELSON MURINE
LEUKEMIA VIRAL
ONCOGENE HOMOLOG 1
ISOFORM B VARIANT)		 5vcx MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE
(Homo
sapiens) 		6 / 12 LEU A 116
VAL A 124
ALA A 137
GLU A 157
THR A 187
GLY A 191
 H8H  A 401 (-3.7A)
H8H  A 401 (-4.7A)
H8H  A 401 (-3.3A)
None
H8H  A 401 (-3.5A)
H8H  A 401 (-4.4A)
 0.75A 3pyyA-5vcxA:
18.1		 3pyyA-5vcxA:
26.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PYY_B_STIB4_1
(V-ABL ABELSON MURINE
LEUKEMIA VIRAL
ONCOGENE HOMOLOG 1
ISOFORM B VARIANT)		 2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Homo
sapiens) 		7 / 12 LEU A 273
VAL A 281
ALA A 293
VAL A 323
THR A 338
LEU A 393
ALA A 403
 H8H  A 534 (-3.8A)
H8H  A 534 (-4.4A)
H8H  A 534 (-3.2A)
None
H8H  A 534 (-3.1A)
H8H  A 534 (-4.5A)
H8H  A 534 ( 4.0A)
 0.80A 3pyyB-2h8hA:
30.5		 3pyyB-2h8hA:
28.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PYY_B_STIB4_1
(V-ABL ABELSON MURINE
LEUKEMIA VIRAL
ONCOGENE HOMOLOG 1
ISOFORM B VARIANT)		 5vcx MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE
(Homo
sapiens) 		6 / 12 LEU A 116
VAL A 124
ALA A 137
GLU A 157
VAL A 171
THR A 187
 H8H  A 401 (-3.7A)
H8H  A 401 (-4.7A)
H8H  A 401 (-3.3A)
None
None
H8H  A 401 (-3.5A)
 0.61A 3pyyB-5vcxA:
18.0		 3pyyB-5vcxA:
26.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QLG_A_1N1A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Homo
sapiens) 		9 / 12 LEU A 273
VAL A 281
ALA A 293
VAL A 323
THR A 338
TYR A 340
GLY A 344
LEU A 393
ALA A 403
 H8H  A 534 (-3.8A)
H8H  A 534 (-4.4A)
H8H  A 534 (-3.2A)
None
H8H  A 534 (-3.1A)
H8H  A 534 (-4.3A)
H8H  A 534 (-3.3A)
H8H  A 534 (-4.5A)
H8H  A 534 ( 4.0A)
 0.55A 3qlgA-2h8hA:
34.3		 3qlgA-2h8hA:
52.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QLG_A_1N1A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Homo
sapiens) 		8 / 12 VAL A 281
ALA A 293
LYS A 295
VAL A 323
THR A 338
TYR A 340
GLY A 344
ALA A 403
 H8H  A 534 (-4.4A)
H8H  A 534 (-3.2A)
H8H  A 534 (-3.7A)
None
H8H  A 534 (-3.1A)
H8H  A 534 (-4.3A)
H8H  A 534 (-3.3A)
H8H  A 534 ( 4.0A)
 0.75A 3qlgA-2h8hA:
34.3		 3qlgA-2h8hA:
52.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QLG_B_1N1B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Homo
sapiens) 		8 / 12 LEU A 273
VAL A 281
ALA A 293
VAL A 323
THR A 338
LEU A 393
ALA A 403
ASP A 404
 H8H  A 534 (-3.8A)
H8H  A 534 (-4.4A)
H8H  A 534 (-3.2A)
None
H8H  A 534 (-3.1A)
H8H  A 534 (-4.5A)
H8H  A 534 ( 4.0A)
H8H  A 534 (-4.2A)
 0.65A 3qlgB-2h8hA:
34.2		 3qlgB-2h8hA:
52.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QLG_B_1N1B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Homo
sapiens) 		9 / 12 LEU A 273
VAL A 281
ALA A 293
VAL A 323
THR A 338
TYR A 340
GLY A 344
LEU A 393
ALA A 403
 H8H  A 534 (-3.8A)
H8H  A 534 (-4.4A)
H8H  A 534 (-3.2A)
None
H8H  A 534 (-3.1A)
H8H  A 534 (-4.3A)
H8H  A 534 (-3.3A)
H8H  A 534 (-4.5A)
H8H  A 534 ( 4.0A)
 0.47A 3qlgB-2h8hA:
34.2		 3qlgB-2h8hA:
52.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QLG_B_1N1B601_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Homo
sapiens) 		4 / 4 LYS A 295
ILE A 336
MET A 341
LYS A 343
 H8H  A 534 (-3.7A)
H8H  A 534 ( 4.5A)
None
None
 0.66A 3qlgB-2h8hA:
34.2		 3qlgB-2h8hA:
52.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SXJ_A_SAMA258_0
(PUTATIVE
METHYLTRANSFERASE)		 2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Homo
sapiens) 		5 / 12 GLY A 344
LEU A 347
GLU A 339
ALA A 403
ASN A 391
 H8H  A 534 (-3.3A)
None
None
H8H  A 534 ( 4.0A)
H8H  A 534 ( 4.9A)
 1.29A 3sxjA-2h8hA:
undetectable		 3sxjA-2h8hA:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SXR_A_1N1A1_1
(CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX)		 2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Homo
sapiens) 		9 / 12 LEU A 273
VAL A 281
ALA A 293
VAL A 323
ILE A 336
THR A 338
TYR A 340
GLY A 344
LEU A 393
 H8H  A 534 (-3.8A)
H8H  A 534 (-4.4A)
H8H  A 534 (-3.2A)
None
H8H  A 534 ( 4.5A)
H8H  A 534 (-3.1A)
H8H  A 534 (-4.3A)
H8H  A 534 (-3.3A)
H8H  A 534 (-4.5A)
 0.47A 3sxrA-2h8hA:
30.8		 3sxrA-2h8hA:
24.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SXR_B_1N1B2_1
(CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX)		 2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Homo
sapiens) 		8 / 12 LEU A 273
VAL A 281
ALA A 293
VAL A 323
THR A 338
TYR A 340
GLY A 344
LEU A 393
 H8H  A 534 (-3.8A)
H8H  A 534 (-4.4A)
H8H  A 534 (-3.2A)
None
H8H  A 534 (-3.1A)
H8H  A 534 (-4.3A)
H8H  A 534 (-3.3A)
H8H  A 534 (-4.5A)
 0.48A 3sxrB-2h8hA:
30.4		 3sxrB-2h8hA:
24.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UE4_A_DB8A601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Homo
sapiens) 		9 / 12 LEU A 273
ALA A 293
LYS A 295
VAL A 323
ILE A 336
THR A 338
MET A 341
GLY A 344
LEU A 393
 H8H  A 534 (-3.8A)
H8H  A 534 (-3.2A)
H8H  A 534 (-3.7A)
None
H8H  A 534 ( 4.5A)
H8H  A 534 (-3.1A)
None
H8H  A 534 (-3.3A)
H8H  A 534 (-4.5A)
 0.48A 3ue4A-2h8hA:
31.6		 3ue4A-2h8hA:
27.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UE4_B_DB8B601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Homo
sapiens) 		8 / 12 LEU A 273
VAL A 281
ALA A 293
VAL A 323
ILE A 336
THR A 338
GLY A 344
LEU A 393
 H8H  A 534 (-3.8A)
H8H  A 534 (-4.4A)
H8H  A 534 (-3.2A)
None
H8H  A 534 ( 4.5A)
H8H  A 534 (-3.1A)
H8H  A 534 (-3.3A)
H8H  A 534 (-4.5A)
 0.50A 3ue4B-2h8hA:
31.1		 3ue4B-2h8hA:
27.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UG2_A_IREA1_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Homo
sapiens) 		7 / 12 LEU A 273
VAL A 281
ALA A 293
LYS A 295
MET A 341
GLY A 344
LEU A 393
 H8H  A 534 (-3.8A)
H8H  A 534 (-4.4A)
H8H  A 534 (-3.2A)
H8H  A 534 (-3.7A)
None
H8H  A 534 (-3.3A)
H8H  A 534 (-4.5A)
 0.69A 3ug2A-2h8hA:
29.2		 3ug2A-2h8hA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UG2_A_IREA1_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Homo
sapiens) 		7 / 12 LEU A 273
VAL A 281
ALA A 293
MET A 341
GLY A 344
ASP A 348
LEU A 393
 H8H  A 534 (-3.8A)
H8H  A 534 (-4.4A)
H8H  A 534 (-3.2A)
None
H8H  A 534 (-3.3A)
None
H8H  A 534 (-4.5A)
 0.71A 3ug2A-2h8hA:
29.2		 3ug2A-2h8hA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V5W_A_8PRA701_1
(G-PROTEIN COUPLED
RECEPTOR KINASE 2)		 2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Homo
sapiens) 		6 / 12 GLY A 276
GLY A 279
VAL A 281
ALA A 293
LYS A 295
LEU A 297
 None
None
H8H  A 534 (-4.4A)
H8H  A 534 (-3.2A)
H8H  A 534 (-3.7A)
None
 0.69A 3v5wA-2h8hA:
7.2		 3v5wA-2h8hA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZBF_A_VGHA3000_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ROS)		 2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Homo
sapiens) 		6 / 12 LEU A 273
ALA A 293
MET A 341
GLY A 344
LEU A 393
ASP A 404
 H8H  A 534 (-3.8A)
H8H  A 534 (-3.2A)
None
H8H  A 534 (-3.3A)
H8H  A 534 (-4.5A)
H8H  A 534 (-4.2A)
 0.68A 3zbfA-2h8hA:
29.1		 3zbfA-2h8hA:
24.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AN2_A_EUIA1382_1
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		 2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Homo
sapiens) 		6 / 12 LYS A 295
LEU A 325
ILE A 336
ASP A 386
ASN A 391
GLY A 406
 H8H  A 534 (-3.7A)
None
H8H  A 534 ( 4.5A)
None
H8H  A 534 ( 4.9A)
None
 1.04A 4an2A-2h8hA:
26.0		 4an2A-2h8hA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ANQ_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Homo
sapiens) 		8 / 9 LEU A 273
VAL A 281
ALA A 293
MET A 341
GLY A 344
LEU A 393
ALA A 403
ASP A 404
 H8H  A 534 (-3.8A)
H8H  A 534 (-4.4A)
H8H  A 534 (-3.2A)
None
H8H  A 534 (-3.3A)
H8H  A 534 (-4.5A)
H8H  A 534 ( 4.0A)
H8H  A 534 (-4.2A)
 0.73A 4anqA-2h8hA:
30.0		 4anqA-2h8hA:
24.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ANS_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Homo
sapiens) 		8 / 9 LEU A 273
VAL A 281
ALA A 293
MET A 341
GLY A 344
LEU A 393
ALA A 403
ASP A 404
 H8H  A 534 (-3.8A)
H8H  A 534 (-4.4A)
H8H  A 534 (-3.2A)
None
H8H  A 534 (-3.3A)
H8H  A 534 (-4.5A)
H8H  A 534 ( 4.0A)
H8H  A 534 (-4.2A)
 0.77A 4ansA-2h8hA:
29.9		 4ansA-2h8hA:
24.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BKJ_B_STIB1000_2
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Homo
sapiens) 		4 / 5 LEU A 317
TYR A 340
MET A 341
ARG A 385
 None
H8H  A 534 (-4.3A)
None
None
 0.92A 4bkjB-2h8hA:
29.0		 4bkjB-2h8hA:
25.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CKI_A_ADNA2022_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET)		 2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Homo
sapiens) 		8 / 11 LEU A 273
GLY A 274
VAL A 281
ALA A 293
TYR A 340
GLY A 344
SER A 345
LEU A 393
 H8H  A 534 (-3.8A)
H8H  A 534 ( 3.8A)
H8H  A 534 (-4.4A)
H8H  A 534 (-3.2A)
H8H  A 534 (-4.3A)
H8H  A 534 (-3.3A)
H8H  A 534 ( 4.5A)
H8H  A 534 (-4.5A)
 0.36A 4ckiA-2h8hA:
30.4		 4ckiA-2h8hA:
25.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CKJ_A_ADNA2014_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET)		 2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Homo
sapiens) 		8 / 10 LEU A 273
GLY A 274
GLY A 276
VAL A 281
ALA A 293
TYR A 340
SER A 345
LEU A 393
 H8H  A 534 (-3.8A)
H8H  A 534 ( 3.8A)
None
H8H  A 534 (-4.4A)
H8H  A 534 (-3.2A)
H8H  A 534 (-4.3A)
H8H  A 534 ( 4.5A)
H8H  A 534 (-4.5A)
 0.45A 4ckjA-2h8hA:
30.8		 4ckjA-2h8hA:
24.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4CSV_A_STIA1265_1
(SRC-ABL TYROSINE
KINASE ANCESTOR)		 2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Homo
sapiens) 		7 / 12 VAL A 281
ALA A 293
VAL A 323
THR A 338
TYR A 340
LEU A 393
ALA A 403
 H8H  A 534 (-4.4A)
H8H  A 534 (-3.2A)
None
H8H  A 534 (-3.1A)
H8H  A 534 (-4.3A)
H8H  A 534 (-4.5A)
H8H  A 534 ( 4.0A)
 0.80A 4csvA-2h8hA:
32.0		 4csvA-2h8hA:
33.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HJO_A_AQ4A1001_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Homo
sapiens) 		9 / 12 LEU A 273
VAL A 281
ALA A 293
LYS A 295
THR A 338
MET A 341
GLY A 344
LEU A 393
ASP A 404
 H8H  A 534 (-3.8A)
H8H  A 534 (-4.4A)
H8H  A 534 (-3.2A)
H8H  A 534 (-3.7A)
H8H  A 534 (-3.1A)
None
H8H  A 534 (-3.3A)
H8H  A 534 (-4.5A)
H8H  A 534 (-4.2A)
 0.47A 4hjoA-2h8hA:
35.5		 4hjoA-2h8hA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I22_A_IREA9001_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Homo
sapiens) 		9 / 12 LEU A 273
GLY A 274
VAL A 281
ALA A 293
LYS A 295
GLY A 344
ASP A 348
LEU A 393
ASP A 404
 H8H  A 534 (-3.8A)
H8H  A 534 ( 3.8A)
H8H  A 534 (-4.4A)
H8H  A 534 (-3.2A)
H8H  A 534 (-3.7A)
H8H  A 534 (-3.3A)
None
H8H  A 534 (-4.5A)
H8H  A 534 (-4.2A)
 0.42A 4i22A-2h8hA:
32.5		 4i22A-2h8hA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IFG_A_1E8A601_1
(CALMODULIN-DOMAIN
PROTEIN KINASE 1)		 2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Homo
sapiens) 		7 / 12 GLY A 274
VAL A 281
ALA A 293
LYS A 295
LEU A 325
LEU A 393
LEU A 407
 H8H  A 534 ( 3.8A)
H8H  A 534 (-4.4A)
H8H  A 534 (-3.2A)
H8H  A 534 (-3.7A)
None
H8H  A 534 (-4.5A)
None
 0.71A 4ifgA-2h8hA:
25.3		 4ifgA-2h8hA:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L9I_A_8PRA601_1
(RHODOPSIN KINASE)		 2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Homo
sapiens) 		4 / 7 VAL A 281
ALA A 293
MET A 341
LEU A 393
 H8H  A 534 (-4.4A)
H8H  A 534 (-3.2A)
None
H8H  A 534 (-4.5A)
 0.73A 4l9iA-2h8hA:
7.5		 4l9iA-2h8hA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L9I_B_8PRB601_1
(RHODOPSIN KINASE)		 2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Homo
sapiens) 		5 / 8 VAL A 281
ALA A 293
LYS A 295
MET A 341
LEU A 393
 H8H  A 534 (-4.4A)
H8H  A 534 (-3.2A)
H8H  A 534 (-3.7A)
None
H8H  A 534 (-4.5A)
 0.83A 4l9iB-2h8hA:
20.6		 4l9iB-2h8hA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LMN_A_EUIA503_1
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		 2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Homo
sapiens) 		5 / 12 LYS A 295
ILE A 336
ASN A 391
ASP A 404
PHE A 405
 H8H  A 534 (-3.7A)
H8H  A 534 ( 4.5A)
H8H  A 534 ( 4.9A)
H8H  A 534 (-4.2A)
None
 0.80A 4lmnA-2h8hA:
24.9		 4lmnA-2h8hA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LMN_A_EUIA503_1
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		 2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Homo
sapiens) 		5 / 12 LYS A 295
ILE A 336
ASN A 391
PHE A 405
GLY A 406
 H8H  A 534 (-3.7A)
H8H  A 534 ( 4.5A)
H8H  A 534 ( 4.9A)
None
None
 0.87A 4lmnA-2h8hA:
24.9		 4lmnA-2h8hA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MKC_A_4MKA1503_1
(ALK TYROSINE KINASE
RECEPTOR)		 2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Homo
sapiens) 		7 / 12 LEU A 273
VAL A 281
ALA A 293
LYS A 295
GLY A 344
LEU A 393
ASP A 404
 H8H  A 534 (-3.8A)
H8H  A 534 (-4.4A)
H8H  A 534 (-3.2A)
H8H  A 534 (-3.7A)
H8H  A 534 (-3.3A)
H8H  A 534 (-4.5A)
H8H  A 534 (-4.2A)
 0.89A 4mkcA-2h8hA:
30.2		 4mkcA-2h8hA:
25.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXO_A_DB8A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Homo
sapiens) 		9 / 12 LEU A 273
VAL A 281
ALA A 293
LYS A 295
VAL A 323
ILE A 336
THR A 338
TYR A 340
GLY A 344
 H8H  A 534 (-3.8A)
H8H  A 534 (-4.4A)
H8H  A 534 (-3.2A)
H8H  A 534 (-3.7A)
None
H8H  A 534 ( 4.5A)
H8H  A 534 (-3.1A)
H8H  A 534 (-4.3A)
H8H  A 534 (-3.3A)
 0.47A 4mxoA-2h8hA:
33.9		 4mxoA-2h8hA:
53.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXO_A_DB8A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Homo
sapiens) 		9 / 12 LEU A 273
VAL A 281
ALA A 293
LYS A 295
VAL A 323
THR A 338
TYR A 340
GLY A 344
ASP A 404
 H8H  A 534 (-3.8A)
H8H  A 534 (-4.4A)
H8H  A 534 (-3.2A)
H8H  A 534 (-3.7A)
None
H8H  A 534 (-3.1A)
H8H  A 534 (-4.3A)
H8H  A 534 (-3.3A)
H8H  A 534 (-4.2A)
 0.80A 4mxoA-2h8hA:
33.9		 4mxoA-2h8hA:
53.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MXO_A_DB8A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 5vcx MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE
(Homo
sapiens) 		8 / 12 LEU A 116
VAL A 124
ALA A 137
LYS A 139
GLU A 157
VAL A 171
THR A 187
ASP A 251
 H8H  A 401 (-3.7A)
H8H  A 401 (-4.7A)
H8H  A 401 (-3.3A)
H8H  A 401 (-4.9A)
None
None
H8H  A 401 (-3.5A)
EDO  A 402 ( 2.9A)
 0.85A 4mxoA-5vcxA:
19.7		 4mxoA-5vcxA:
26.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXO_B_DB8B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Homo
sapiens) 		10 / 12 LEU A 273
VAL A 281
ALA A 293
LYS A 295
VAL A 323
ILE A 336
THR A 338
TYR A 340
GLY A 344
LEU A 393
 H8H  A 534 (-3.8A)
H8H  A 534 (-4.4A)
H8H  A 534 (-3.2A)
H8H  A 534 (-3.7A)
None
H8H  A 534 ( 4.5A)
H8H  A 534 (-3.1A)
H8H  A 534 (-4.3A)
H8H  A 534 (-3.3A)
H8H  A 534 (-4.5A)
 0.52A 4mxoB-2h8hA:
33.9		 4mxoB-2h8hA:
53.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXO_B_DB8B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Homo
sapiens) 		9 / 12 LEU A 273
VAL A 281
ALA A 293
VAL A 323
THR A 338
TYR A 340
GLY A 344
LEU A 393
ASP A 404
 H8H  A 534 (-3.8A)
H8H  A 534 (-4.4A)
H8H  A 534 (-3.2A)
None
H8H  A 534 (-3.1A)
H8H  A 534 (-4.3A)
H8H  A 534 (-3.3A)
H8H  A 534 (-4.5A)
H8H  A 534 (-4.2A)
 0.67A 4mxoB-2h8hA:
33.9		 4mxoB-2h8hA:
53.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXX_A_DB8A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Homo
sapiens) 		9 / 12 LEU A 273
ALA A 293
LYS A 295
VAL A 323
ILE A 336
THR A 338
TYR A 340
GLY A 344
LEU A 393
 H8H  A 534 (-3.8A)
H8H  A 534 (-3.2A)
H8H  A 534 (-3.7A)
None
H8H  A 534 ( 4.5A)
H8H  A 534 (-3.1A)
H8H  A 534 (-4.3A)
H8H  A 534 (-3.3A)
H8H  A 534 (-4.5A)
 0.55A 4mxxA-2h8hA:
33.8		 4mxxA-2h8hA:
53.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXX_B_DB8B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Homo
sapiens) 		10 / 12 LEU A 273
VAL A 281
ALA A 293
LYS A 295
VAL A 323
THR A 338
TYR A 340
MET A 341
GLY A 344
LEU A 393
 H8H  A 534 (-3.8A)
H8H  A 534 (-4.4A)
H8H  A 534 (-3.2A)
H8H  A 534 (-3.7A)
None
H8H  A 534 (-3.1A)
H8H  A 534 (-4.3A)
None
H8H  A 534 (-3.3A)
H8H  A 534 (-4.5A)
 0.46A 4mxxB-2h8hA:
33.6		 4mxxB-2h8hA:
53.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXY_A_DB8A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Homo
sapiens) 		9 / 12 LEU A 273
VAL A 281
ALA A 293
VAL A 323
ILE A 336
TYR A 340
GLY A 344
LEU A 393
ASP A 404
 H8H  A 534 (-3.8A)
H8H  A 534 (-4.4A)
H8H  A 534 (-3.2A)
None
H8H  A 534 ( 4.5A)
H8H  A 534 (-4.3A)
H8H  A 534 (-3.3A)
H8H  A 534 (-4.5A)
H8H  A 534 (-4.2A)
 0.54A 4mxyA-2h8hA:
34.5		 4mxyA-2h8hA:
52.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXY_B_DB8B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Homo
sapiens) 		9 / 12 LEU A 273
VAL A 281
ALA A 293
LYS A 295
VAL A 323
TYR A 340
GLY A 344
LEU A 393
ASP A 404
 H8H  A 534 (-3.8A)
H8H  A 534 (-4.4A)
H8H  A 534 (-3.2A)
H8H  A 534 (-3.7A)
None
H8H  A 534 (-4.3A)
H8H  A 534 (-3.3A)
H8H  A 534 (-4.5A)
H8H  A 534 (-4.2A)
 0.74A 4mxyB-2h8hA:
34.1		 4mxyB-2h8hA:
52.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXY_B_DB8B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Homo
sapiens) 		9 / 12 LEU A 273
VAL A 281
ALA A 293
VAL A 323
TYR A 340
GLY A 344
LEU A 393
ALA A 403
ASP A 404
 H8H  A 534 (-3.8A)
H8H  A 534 (-4.4A)
H8H  A 534 (-3.2A)
None
H8H  A 534 (-4.3A)
H8H  A 534 (-3.3A)
H8H  A 534 (-4.5A)
H8H  A 534 ( 4.0A)
H8H  A 534 (-4.2A)
 0.57A 4mxyB-2h8hA:
34.1		 4mxyB-2h8hA:
52.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXZ_A_DB8A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Homo
sapiens) 		9 / 12 LEU A 273
VAL A 281
ALA A 293
VAL A 323
ILE A 336
TYR A 340
GLY A 344
LEU A 393
ASP A 404
 H8H  A 534 (-3.8A)
H8H  A 534 (-4.4A)
H8H  A 534 (-3.2A)
None
H8H  A 534 ( 4.5A)
H8H  A 534 (-4.3A)
H8H  A 534 (-3.3A)
H8H  A 534 (-4.5A)
H8H  A 534 (-4.2A)
 0.54A 4mxzA-2h8hA:
34.5		 4mxzA-2h8hA:
52.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXZ_B_DB8B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Homo
sapiens) 		9 / 12 LEU A 273
VAL A 281
ALA A 293
LYS A 295
VAL A 323
TYR A 340
GLY A 344
LEU A 393
ASP A 404
 H8H  A 534 (-3.8A)
H8H  A 534 (-4.4A)
H8H  A 534 (-3.2A)
H8H  A 534 (-3.7A)
None
H8H  A 534 (-4.3A)
H8H  A 534 (-3.3A)
H8H  A 534 (-4.5A)
H8H  A 534 (-4.2A)
 0.74A 4mxzB-2h8hA:
34.1		 4mxzB-2h8hA:
52.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXZ_B_DB8B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Homo
sapiens) 		9 / 12 LEU A 273
VAL A 281
ALA A 293
VAL A 323
TYR A 340
GLY A 344
LEU A 393
ALA A 403
ASP A 404
 H8H  A 534 (-3.8A)
H8H  A 534 (-4.4A)
H8H  A 534 (-3.2A)
None
H8H  A 534 (-4.3A)
H8H  A 534 (-3.3A)
H8H  A 534 (-4.5A)
H8H  A 534 ( 4.0A)
H8H  A 534 (-4.2A)
 0.57A 4mxzB-2h8hA:
34.1		 4mxzB-2h8hA:
52.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O0U_A_ADNA501_1
(AURORA KINASE A)		 2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Homo
sapiens) 		4 / 6 VAL A 281
ALA A 293
LYS A 295
LEU A 393
 H8H  A 534 (-4.4A)
H8H  A 534 (-3.2A)
H8H  A 534 (-3.7A)
H8H  A 534 (-4.5A)
 0.60A 4o0uA-2h8hA:
8.2		 4o0uA-2h8hA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OGR_A_ADNA401_1
(CYCLIN-DEPENDENT
KINASE 9)		 2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Homo
sapiens) 		5 / 8 VAL A 281
ALA A 293
ASN A 391
LEU A 393
ASP A 404
 H8H  A 534 (-4.4A)
H8H  A 534 (-3.2A)
H8H  A 534 ( 4.9A)
H8H  A 534 (-4.5A)
H8H  A 534 (-4.2A)
 0.59A 4ogrA-2h8hA:
23.3		 4ogrA-2h8hA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OGR_E_ADNE401_1
(CYCLIN-DEPENDENT
KINASE 9)		 2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Homo
sapiens) 		4 / 7 ALA A 293
ASN A 391
LEU A 393
ASP A 404
 H8H  A 534 (-3.2A)
H8H  A 534 ( 4.9A)
H8H  A 534 (-4.5A)
H8H  A 534 (-4.2A)
 0.27A 4ogrE-2h8hA:
23.0		 4ogrE-2h8hA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OTW_A_DB8A1101_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-3)		 2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Homo
sapiens) 		10 / 12 LEU A 273
VAL A 281
LYS A 295
VAL A 323
THR A 338
TYR A 340
GLY A 344
LEU A 393
ALA A 403
ASP A 404
 H8H  A 534 (-3.8A)
H8H  A 534 (-4.4A)
H8H  A 534 (-3.7A)
None
H8H  A 534 (-3.1A)
H8H  A 534 (-4.3A)
H8H  A 534 (-3.3A)
H8H  A 534 (-4.5A)
H8H  A 534 ( 4.0A)
H8H  A 534 (-4.2A)
 0.54A 4otwA-2h8hA:
33.5		 4otwA-2h8hA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PWJ_A_30ZA201_1
(TRANSTHYRETIN)		 2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Homo
sapiens) 		4 / 6 LYS A 295
LEU A 297
THR A 338
SER A 330
 H8H  A 534 (-3.7A)
None
H8H  A 534 (-3.1A)
None
 0.84A 4pwjA-2h8hA:
undetectable		 4pwjA-2h8hA:
15.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QRC_A_0LIA802_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Homo
sapiens) 		4 / 8 LEU A 273
VAL A 281
HIS A 384
LEU A 393
 H8H  A 534 (-3.8A)
H8H  A 534 (-4.4A)
None
H8H  A 534 (-4.5A)
 0.49A 4qrcA-2h8hA:
30.1		 4qrcA-2h8hA:
25.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R7I_A_STIA1001_1
(MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR)		 5vcx MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE
(Homo
sapiens) 		6 / 12 VAL A 124
ALA A 137
GLU A 157
THR A 187
CYH A 190
GLY A 250
 H8H  A 401 (-4.7A)
H8H  A 401 (-3.3A)
None
H8H  A 401 (-3.5A)
H8H  A 401 (-4.3A)
None
 0.60A 4r7iA-5vcxA:
22.7		 4r7iA-5vcxA:
28.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R7I_A_STIA1001_2
(MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR)		 2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Homo
sapiens) 		4 / 5 LEU A 273
VAL A 323
TYR A 340
ARG A 385
 H8H  A 534 (-3.8A)
None
H8H  A 534 (-4.3A)
None
 0.85A 4r7iA-2h8hA:
29.7		 4r7iA-2h8hA:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZV_A_032A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Homo
sapiens) 		5 / 12 ALA A 293
ILE A 336
THR A 338
SER A 345
PHE A 405
 H8H  A 534 (-3.2A)
H8H  A 534 ( 4.5A)
H8H  A 534 (-3.1A)
H8H  A 534 ( 4.5A)
None
 0.72A 4rzvA-2h8hA:
7.6		 4rzvA-2h8hA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZV_A_032A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Homo
sapiens) 		5 / 12 ALA A 293
LYS A 295
ILE A 336
THR A 338
SER A 345
 H8H  A 534 (-3.2A)
H8H  A 534 (-3.7A)
H8H  A 534 ( 4.5A)
H8H  A 534 (-3.1A)
H8H  A 534 ( 4.5A)
 0.85A 4rzvA-2h8hA:
7.6		 4rzvA-2h8hA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZV_A_032A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Homo
sapiens) 		5 / 12 ILE A 336
THR A 338
SER A 345
PHE A 405
GLY A 406
 H8H  A 534 ( 4.5A)
H8H  A 534 (-3.1A)
H8H  A 534 ( 4.5A)
None
None
 0.94A 4rzvA-2h8hA:
7.6		 4rzvA-2h8hA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZV_A_032A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 5vcx MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE
(Homo
sapiens) 		6 / 12 ALA A 137
THR A 187
SER A 193
PHE A 240
GLY A 250
GLY A 253
 H8H  A 401 (-3.3A)
H8H  A 401 (-3.5A)
H8H  A 401 ( 4.4A)
H8H  A 401 (-4.3A)
None
None
 1.11A 4rzvA-5vcxA:
5.4		 4rzvA-5vcxA:
26.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZV_A_032A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 5vcx MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE
(Homo
sapiens) 		6 / 12 ALA A 137
THR A 187
SER A 193
PHE A 240
GLY A 250
PHE A 252
 H8H  A 401 (-3.3A)
H8H  A 401 (-3.5A)
H8H  A 401 ( 4.4A)
H8H  A 401 (-4.3A)
None
None
 0.78A 4rzvA-5vcxA:
5.4		 4rzvA-5vcxA:
26.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZV_B_032B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Homo
sapiens) 		5 / 12 VAL A 281
ALA A 293
LYS A 295
THR A 338
SER A 345
 H8H  A 534 (-4.4A)
H8H  A 534 (-3.2A)
H8H  A 534 (-3.7A)
H8H  A 534 (-3.1A)
H8H  A 534 ( 4.5A)
 0.79A 4rzvB-2h8hA:
28.8		 4rzvB-2h8hA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZV_B_032B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Homo
sapiens) 		5 / 12 VAL A 281
ALA A 293
THR A 338
SER A 345
PHE A 405
 H8H  A 534 (-4.4A)
H8H  A 534 (-3.2A)
H8H  A 534 (-3.1A)
H8H  A 534 ( 4.5A)
None
 0.56A 4rzvB-2h8hA:
28.8		 4rzvB-2h8hA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZV_B_032B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 5vcx MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE
(Homo
sapiens) 		7 / 12 ALA A 137
THR A 187
CYH A 190
SER A 193
PHE A 240
GLY A 250
GLY A 253
 H8H  A 401 (-3.3A)
H8H  A 401 (-3.5A)
H8H  A 401 (-4.3A)
H8H  A 401 ( 4.4A)
H8H  A 401 (-4.3A)
None
None
 1.17A 4rzvB-5vcxA:
17.4		 4rzvB-5vcxA:
26.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZV_B_032B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 5vcx MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE
(Homo
sapiens) 		7 / 12 ALA A 137
THR A 187
CYH A 190
SER A 193
PHE A 240
GLY A 250
PHE A 252
 H8H  A 401 (-3.3A)
H8H  A 401 (-3.5A)
H8H  A 401 (-4.3A)
H8H  A 401 ( 4.4A)
H8H  A 401 (-4.3A)
None
None
 0.88A 4rzvB-5vcxA:
17.4		 4rzvB-5vcxA:
26.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZV_B_032B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 5vcx MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE
(Homo
sapiens) 		6 / 12 VAL A 124
ALA A 137
LYS A 139
THR A 187
CYH A 190
GLY A 253
 H8H  A 401 (-4.7A)
H8H  A 401 (-3.3A)
H8H  A 401 (-4.9A)
H8H  A 401 (-3.5A)
H8H  A 401 (-4.3A)
None
 1.11A 4rzvB-5vcxA:
17.4		 4rzvB-5vcxA:
26.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZV_B_032B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 5vcx MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE
(Homo
sapiens) 		7 / 12 VAL A 124
ALA A 137
THR A 187
CYH A 190
SER A 193
PHE A 240
GLY A 253
 H8H  A 401 (-4.7A)
H8H  A 401 (-3.3A)
H8H  A 401 (-3.5A)
H8H  A 401 (-4.3A)
H8H  A 401 ( 4.4A)
H8H  A 401 (-4.3A)
None
 0.96A 4rzvB-5vcxA:
17.4		 4rzvB-5vcxA:
26.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZV_B_032B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 5vcx MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE
(Homo
sapiens) 		7 / 12 VAL A 124
ALA A 137
THR A 187
CYH A 190
SER A 193
PHE A 240
PHE A 252
 H8H  A 401 (-4.7A)
H8H  A 401 (-3.3A)
H8H  A 401 (-3.5A)
H8H  A 401 (-4.3A)
H8H  A 401 ( 4.4A)
H8H  A 401 (-4.3A)
None
 0.91A 4rzvB-5vcxA:
17.4		 4rzvB-5vcxA:
26.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4TWP_A_AXIA601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Homo
sapiens) 		9 / 12 LEU A 273
VAL A 281
ALA A 293
MET A 341
GLY A 344
ASN A 391
LEU A 393
ALA A 403
ASP A 404
 H8H  A 534 (-3.8A)
H8H  A 534 (-4.4A)
H8H  A 534 (-3.2A)
None
H8H  A 534 (-3.3A)
H8H  A 534 ( 4.9A)
H8H  A 534 (-4.5A)
H8H  A 534 ( 4.0A)
H8H  A 534 (-4.2A)
 0.71A 4twpA-2h8hA:
31.2		 4twpA-2h8hA:
33.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4TWP_B_AXIB601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Homo
sapiens) 		9 / 12 LEU A 273
VAL A 281
ALA A 293
MET A 341
GLY A 344
ASN A 391
LEU A 393
ALA A 403
ASP A 404
 H8H  A 534 (-3.8A)
H8H  A 534 (-4.4A)
H8H  A 534 (-3.2A)
None
H8H  A 534 (-3.3A)
H8H  A 534 ( 4.9A)
H8H  A 534 (-4.5A)
H8H  A 534 ( 4.0A)
H8H  A 534 (-4.2A)
 0.74A 4twpB-2h8hA:
30.9		 4twpB-2h8hA:
33.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4U5J_A_RXTA601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Homo
sapiens) 		11 / 11 LEU A 273
GLY A 276
VAL A 281
ALA A 293
TYR A 340
MET A 341
GLY A 344
ASN A 391
LEU A 393
ALA A 403
ASP A 404
 H8H  A 534 (-3.8A)
None
H8H  A 534 (-4.4A)
H8H  A 534 (-3.2A)
H8H  A 534 (-4.3A)
None
H8H  A 534 (-3.3A)
H8H  A 534 ( 4.9A)
H8H  A 534 (-4.5A)
H8H  A 534 ( 4.0A)
H8H  A 534 (-4.2A)
 0.67A 4u5jA-2h8hA:
35.4		 4u5jA-2h8hA:
52.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4U5J_B_RXTB601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Homo
sapiens) 		6 / 9 LEU A 273
TYR A 340
MET A 341
GLY A 344
LEU A 393
ASP A 404
 H8H  A 534 (-3.8A)
H8H  A 534 (-4.3A)
None
H8H  A 534 (-3.3A)
H8H  A 534 (-4.5A)
H8H  A 534 (-4.2A)
 0.76A 4u5jB-2h8hA:
34.9		 4u5jB-2h8hA:
52.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4U5J_B_RXTB601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Homo
sapiens) 		7 / 9 LEU A 273
VAL A 281
ALA A 293
TYR A 340
MET A 341
GLY A 344
LEU A 393
 H8H  A 534 (-3.8A)
H8H  A 534 (-4.4A)
H8H  A 534 (-3.2A)
H8H  A 534 (-4.3A)
None
H8H  A 534 (-3.3A)
H8H  A 534 (-4.5A)
 0.24A 4u5jB-2h8hA:
34.9		 4u5jB-2h8hA:
52.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UXQ_A_0LIA1752_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Homo
sapiens) 		5 / 12 LEU A 273
ALA A 293
HIS A 384
LEU A 393
ALA A 403
 H8H  A 534 (-3.8A)
H8H  A 534 (-3.2A)
None
H8H  A 534 (-4.5A)
H8H  A 534 ( 4.0A)
 0.58A 4uxqA-2h8hA:
30.3		 4uxqA-2h8hA:
25.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UXQ_A_0LIA1752_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 5vcx MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE
(Homo
sapiens) 		5 / 12 LEU A 116
ALA A 137
GLU A 157
LEU A 224
HIS A 231
 H8H  A 401 (-3.7A)
H8H  A 401 (-3.3A)
None
None
None
 0.59A 4uxqA-5vcxA:
22.9		 4uxqA-5vcxA:
24.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WA9_A_AXIA9000_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Homo
sapiens) 		7 / 11 ALA A 293
THR A 338
MET A 341
GLY A 344
ASN A 391
LEU A 393
ALA A 403
 H8H  A 534 (-3.2A)
H8H  A 534 (-3.1A)
None
H8H  A 534 (-3.3A)
H8H  A 534 ( 4.9A)
H8H  A 534 (-4.5A)
H8H  A 534 ( 4.0A)
 0.57A 4wa9A-2h8hA:
28.7		 4wa9A-2h8hA:
27.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WA9_A_AXIA9000_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Homo
sapiens) 		7 / 11 LEU A 273
ALA A 293
LYS A 295
THR A 338
MET A 341
GLY A 344
LEU A 393
 H8H  A 534 (-3.8A)
H8H  A 534 (-3.2A)
H8H  A 534 (-3.7A)
H8H  A 534 (-3.1A)
None
H8H  A 534 (-3.3A)
H8H  A 534 (-4.5A)
 0.79A 4wa9A-2h8hA:
28.7		 4wa9A-2h8hA:
27.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WA9_B_AXIB9000_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Homo
sapiens) 		8 / 12 VAL A 281
ALA A 293
THR A 338
MET A 341
GLY A 344
ASN A 391
LEU A 393
ALA A 403
 H8H  A 534 (-4.4A)
H8H  A 534 (-3.2A)
H8H  A 534 (-3.1A)
None
H8H  A 534 (-3.3A)
H8H  A 534 ( 4.9A)
H8H  A 534 (-4.5A)
H8H  A 534 ( 4.0A)
 0.80A 4wa9B-2h8hA:
30.4		 4wa9B-2h8hA:
27.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WBO_C_ANWC601_0
(RHODOPSIN KINASE)		 2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Homo
sapiens) 		4 / 6 LEU A 273
ALA A 293
MET A 341
LEU A 393
 H8H  A 534 (-3.8A)
H8H  A 534 (-3.2A)
None
H8H  A 534 (-4.5A)
 0.52A 4wboC-2h8hA:
20.8		 4wboC-2h8hA:
23.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WKQ_A_IREA1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Homo
sapiens) 		7 / 12 LEU A 273
ALA A 293
LYS A 295
THR A 338
GLY A 344
ASP A 348
LEU A 393
 H8H  A 534 (-3.8A)
H8H  A 534 (-3.2A)
H8H  A 534 (-3.7A)
H8H  A 534 (-3.1A)
H8H  A 534 (-3.3A)
None
H8H  A 534 (-4.5A)
 0.57A 4wkqA-2h8hA:
29.8		 4wkqA-2h8hA:
22.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XEY_A_1N1A601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Homo
sapiens) 		10 / 12 LEU A 273
VAL A 281
ALA A 293
LYS A 295
VAL A 323
ILE A 336
THR A 338
GLY A 344
LEU A 393
ALA A 403
 H8H  A 534 (-3.8A)
H8H  A 534 (-4.4A)
H8H  A 534 (-3.2A)
H8H  A 534 (-3.7A)
None
H8H  A 534 ( 4.5A)
H8H  A 534 (-3.1A)
H8H  A 534 (-3.3A)
H8H  A 534 (-4.5A)
H8H  A 534 ( 4.0A)
 0.56A 4xeyA-2h8hA:
31.4		 4xeyA-2h8hA:
34.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XEY_B_1N1B601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Homo
sapiens) 		9 / 12 LEU A 273
VAL A 281
ALA A 293
LYS A 295
VAL A 323
ILE A 336
THR A 338
GLY A 344
LEU A 393
 H8H  A 534 (-3.8A)
H8H  A 534 (-4.4A)
H8H  A 534 (-3.2A)
H8H  A 534 (-3.7A)
None
H8H  A 534 ( 4.5A)
H8H  A 534 (-3.1A)
H8H  A 534 (-3.3A)
H8H  A 534 (-4.5A)
 0.42A 4xeyB-2h8hA:
31.1		 4xeyB-2h8hA:
34.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XEY_B_1N1B601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Homo
sapiens) 		9 / 12 VAL A 281
ALA A 293
LYS A 295
VAL A 323
ILE A 336
THR A 338
GLY A 344
LEU A 393
ALA A 403
 H8H  A 534 (-4.4A)
H8H  A 534 (-3.2A)
H8H  A 534 (-3.7A)
None
H8H  A 534 ( 4.5A)
H8H  A 534 (-3.1A)
H8H  A 534 (-3.3A)
H8H  A 534 (-4.5A)
H8H  A 534 ( 4.0A)
 0.53A 4xeyB-2h8hA:
31.1		 4xeyB-2h8hA:
34.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XLI_A_1N1A601_1
(NON-SPECIFIC
PROTEIN-TYROSINE
KINASE)		 2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Homo
sapiens) 		8 / 12 LEU A 273
ALA A 293
LYS A 295
VAL A 323
THR A 338
TYR A 340
MET A 341
GLY A 344
 H8H  A 534 (-3.8A)
H8H  A 534 (-3.2A)
H8H  A 534 (-3.7A)
None
H8H  A 534 (-3.1A)
H8H  A 534 (-4.3A)
None
H8H  A 534 (-3.3A)
 0.50A 4xliA-2h8hA:
31.4		 4xliA-2h8hA:
35.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XLI_A_1N1A601_1
(NON-SPECIFIC
PROTEIN-TYROSINE
KINASE)		 2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Homo
sapiens) 		9 / 12 LEU A 273
ALA A 293
VAL A 323
THR A 338
TYR A 340
MET A 341
GLY A 344
LEU A 393
ALA A 403
 H8H  A 534 (-3.8A)
H8H  A 534 (-3.2A)
None
H8H  A 534 (-3.1A)
H8H  A 534 (-4.3A)
None
H8H  A 534 (-3.3A)
H8H  A 534 (-4.5A)
H8H  A 534 ( 4.0A)
 0.43A 4xliA-2h8hA:
31.4		 4xliA-2h8hA:
35.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XLI_B_1N1B600_1
(NON-SPECIFIC
PROTEIN-TYROSINE
KINASE)		 2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Homo
sapiens) 		10 / 12 LEU A 273
ALA A 293
LYS A 295
VAL A 323
ILE A 336
THR A 338
TYR A 340
GLY A 344
LEU A 393
ALA A 403
 H8H  A 534 (-3.8A)
H8H  A 534 (-3.2A)
H8H  A 534 (-3.7A)
None
H8H  A 534 ( 4.5A)
H8H  A 534 (-3.1A)
H8H  A 534 (-4.3A)
H8H  A 534 (-3.3A)
H8H  A 534 (-4.5A)
H8H  A 534 ( 4.0A)
 0.64A 4xliB-2h8hA:
31.1		 4xliB-2h8hA:
35.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XV2_A_P06A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 5vcx MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE
(Homo
sapiens) 		7 / 12 VAL A 124
ALA A 137
THR A 187
CYH A 190
PHE A 240
GLY A 250
ASP A 251
 H8H  A 401 (-4.7A)
H8H  A 401 (-3.3A)
H8H  A 401 (-3.5A)
H8H  A 401 (-4.3A)
H8H  A 401 (-4.3A)
None
EDO  A 402 ( 2.9A)
 0.76A 4xv2A-5vcxA:
18.5		 4xv2A-5vcxA:
25.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XV2_A_P06A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 5vcx MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE
(Homo
sapiens) 		7 / 12 VAL A 124
ALA A 137
THR A 187
PHE A 240
GLY A 250
ASP A 251
PHE A 252
 H8H  A 401 (-4.7A)
H8H  A 401 (-3.3A)
H8H  A 401 (-3.5A)
H8H  A 401 (-4.3A)
None
EDO  A 402 ( 2.9A)
None
 0.81A 4xv2A-5vcxA:
18.5		 4xv2A-5vcxA:
25.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XV2_B_P06B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 5vcx MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE
(Homo
sapiens) 		6 / 12 ALA A 137
THR A 187
CYH A 190
PHE A 240
GLY A 250
ASP A 251
 H8H  A 401 (-3.3A)
H8H  A 401 (-3.5A)
H8H  A 401 (-4.3A)
H8H  A 401 (-4.3A)
None
EDO  A 402 ( 2.9A)
 0.67A 4xv2B-5vcxA:
22.6		 4xv2B-5vcxA:
25.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XV2_B_P06B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 5vcx MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE
(Homo
sapiens) 		6 / 12 ALA A 137
THR A 187
PHE A 240
GLY A 250
ASP A 251
PHE A 252
 H8H  A 401 (-3.3A)
H8H  A 401 (-3.5A)
H8H  A 401 (-4.3A)
None
EDO  A 402 ( 2.9A)
None
 0.65A 4xv2B-5vcxA:
22.6		 4xv2B-5vcxA:
25.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZAU_A_YY3A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Homo
sapiens) 		6 / 8 LEU A 273
GLY A 274
VAL A 281
ALA A 293
MET A 341
GLY A 344
 H8H  A 534 (-3.8A)
H8H  A 534 ( 3.8A)
H8H  A 534 (-4.4A)
H8H  A 534 (-3.2A)
None
H8H  A 534 (-3.3A)
 0.42A 4zauA-2h8hA:
29.7		 4zauA-2h8hA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AAA_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Homo
sapiens) 		7 / 9 LEU A 273
VAL A 281
ALA A 293
MET A 341
GLY A 344
LEU A 393
ASP A 404
 H8H  A 534 (-3.8A)
H8H  A 534 (-4.4A)
H8H  A 534 (-3.2A)
None
H8H  A 534 (-3.3A)
H8H  A 534 (-4.5A)
H8H  A 534 (-4.2A)
 0.63A 5aaaA-2h8hA:
30.4		 5aaaA-2h8hA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AAB_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Homo
sapiens) 		7 / 10 LEU A 273
VAL A 281
ALA A 293
LYS A 295
MET A 341
GLY A 344
LEU A 393
 H8H  A 534 (-3.8A)
H8H  A 534 (-4.4A)
H8H  A 534 (-3.2A)
H8H  A 534 (-3.7A)
None
H8H  A 534 (-3.3A)
H8H  A 534 (-4.5A)
 0.49A 5aabA-2h8hA:
30.2		 5aabA-2h8hA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AAB_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Homo
sapiens) 		7 / 10 LEU A 273
VAL A 281
ALA A 293
MET A 341
GLY A 344
LEU A 393
ASP A 404
 H8H  A 534 (-3.8A)
H8H  A 534 (-4.4A)
H8H  A 534 (-3.2A)
None
H8H  A 534 (-3.3A)
H8H  A 534 (-4.5A)
H8H  A 534 (-4.2A)
 0.59A 5aabA-2h8hA:
30.2		 5aabA-2h8hA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AAC_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Homo
sapiens) 		7 / 10 LEU A 273
VAL A 281
ALA A 293
LYS A 295
MET A 341
GLY A 344
LEU A 393
 H8H  A 534 (-3.8A)
H8H  A 534 (-4.4A)
H8H  A 534 (-3.2A)
H8H  A 534 (-3.7A)
None
H8H  A 534 (-3.3A)
H8H  A 534 (-4.5A)
 0.49A 5aacA-2h8hA:
30.0		 5aacA-2h8hA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AAC_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Homo
sapiens) 		7 / 10 LEU A 273
VAL A 281
ALA A 293
MET A 341
GLY A 344
LEU A 393
ASP A 404
 H8H  A 534 (-3.8A)
H8H  A 534 (-4.4A)
H8H  A 534 (-3.2A)
None
H8H  A 534 (-3.3A)
H8H  A 534 (-4.5A)
H8H  A 534 (-4.2A)
 0.74A 5aacA-2h8hA:
30.0		 5aacA-2h8hA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AJQ_A_DB8A800_1
(SERINE/THREONINE-PRO
TEIN KINASE 10)		 2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Homo
sapiens) 		6 / 12 LEU A 273
ALA A 293
GLY A 344
LEU A 393
ALA A 403
ASP A 404
 H8H  A 534 (-3.8A)
H8H  A 534 (-3.2A)
H8H  A 534 (-3.3A)
H8H  A 534 (-4.5A)
H8H  A 534 ( 4.0A)
H8H  A 534 (-4.2A)
 0.50A 5ajqA-2h8hA:
25.0		 5ajqA-2h8hA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AJQ_A_DB8A800_1
(SERINE/THREONINE-PRO
TEIN KINASE 10)		 2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Homo
sapiens) 		6 / 12 LEU A 273
ALA A 293
LYS A 295
GLY A 344
LEU A 393
ALA A 403
 H8H  A 534 (-3.8A)
H8H  A 534 (-3.2A)
H8H  A 534 (-3.7A)
H8H  A 534 (-3.3A)
H8H  A 534 (-4.5A)
H8H  A 534 ( 4.0A)
 0.79A 5ajqA-2h8hA:
25.0		 5ajqA-2h8hA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AJQ_A_DB8A800_1
(SERINE/THREONINE-PRO
TEIN KINASE 10)		 2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Homo
sapiens) 		6 / 12 LEU A 273
GLY A 274
ALA A 293
GLY A 344
LEU A 393
ALA A 403
 H8H  A 534 (-3.8A)
H8H  A 534 ( 3.8A)
H8H  A 534 (-3.2A)
H8H  A 534 (-3.3A)
H8H  A 534 (-4.5A)
H8H  A 534 ( 4.0A)
 0.87A 5ajqA-2h8hA:
25.0		 5ajqA-2h8hA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AJQ_B_DB8B800_1
(SERINE/THREONINE-PRO
TEIN KINASE 10)		 2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Homo
sapiens) 		5 / 10 ALA A 293
GLY A 344
LEU A 393
ALA A 403
ASP A 404
 H8H  A 534 (-3.2A)
H8H  A 534 (-3.3A)
H8H  A 534 (-4.5A)
H8H  A 534 ( 4.0A)
H8H  A 534 (-4.2A)
 0.23A 5ajqB-2h8hA:
24.4		 5ajqB-2h8hA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BOJ_B_4TXB201_1
(TRANSTHYRETIN)		 2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Homo
sapiens) 		4 / 7 LYS A 295
LEU A 297
THR A 338
SER A 330
 H8H  A 534 (-3.7A)
None
H8H  A 534 (-3.1A)
None
 0.81A 5bojB-2h8hA:
undetectable		 5bojB-2h8hA:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BVW_A_1N1A1009_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Homo
sapiens) 		9 / 12 LEU A 273
VAL A 281
ALA A 293
LYS A 295
THR A 338
TYR A 340
GLY A 344
LEU A 393
ALA A 403
 H8H  A 534 (-3.8A)
H8H  A 534 (-4.4A)
H8H  A 534 (-3.2A)
H8H  A 534 (-3.7A)
H8H  A 534 (-3.1A)
H8H  A 534 (-4.3A)
H8H  A 534 (-3.3A)
H8H  A 534 (-4.5A)
H8H  A 534 ( 4.0A)
 0.72A 5bvwA-2h8hA:
29.0		 5bvwA-2h8hA:
25.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSW_A_P06A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 5vcx MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE
(Homo
sapiens) 		6 / 12 VAL A 124
ALA A 137
THR A 187
CYH A 190
PHE A 240
GLY A 250
 H8H  A 401 (-4.7A)
H8H  A 401 (-3.3A)
H8H  A 401 (-3.5A)
H8H  A 401 (-4.3A)
H8H  A 401 (-4.3A)
None
 0.66A 5cswA-5vcxA:
22.0		 5cswA-5vcxA:
24.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSW_A_P06A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 5vcx MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE
(Homo
sapiens) 		6 / 12 VAL A 124
ALA A 137
THR A 187
PHE A 240
GLY A 250
PHE A 252
 H8H  A 401 (-4.7A)
H8H  A 401 (-3.3A)
H8H  A 401 (-3.5A)
H8H  A 401 (-4.3A)
None
None
 0.84A 5cswA-5vcxA:
22.0		 5cswA-5vcxA:
24.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSW_B_P06B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 5vcx MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE
(Homo
sapiens) 		6 / 12 VAL A 124
ALA A 137
THR A 187
CYH A 190
PHE A 240
GLY A 250
 H8H  A 401 (-4.7A)
H8H  A 401 (-3.3A)
H8H  A 401 (-3.5A)
H8H  A 401 (-4.3A)
H8H  A 401 (-4.3A)
None
 0.63A 5cswB-5vcxA:
22.4		 5cswB-5vcxA:
24.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSW_B_P06B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 5vcx MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE
(Homo
sapiens) 		6 / 12 VAL A 124
ALA A 137
THR A 187
PHE A 240
GLY A 250
PHE A 252
 H8H  A 401 (-4.7A)
H8H  A 401 (-3.3A)
H8H  A 401 (-3.5A)
H8H  A 401 (-4.3A)
None
None
 0.83A 5cswB-5vcxA:
22.4		 5cswB-5vcxA:
24.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H2U_A_1N1A501_1
(PROTEIN-TYROSINE
KINASE 6)		 2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Homo
sapiens) 		6 / 12 LEU A 273
VAL A 281
ALA A 293
THR A 338
GLY A 344
LEU A 393
 H8H  A 534 (-3.8A)
H8H  A 534 (-4.4A)
H8H  A 534 (-3.2A)
H8H  A 534 (-3.1A)
H8H  A 534 (-3.3A)
H8H  A 534 (-4.5A)
 0.41A 5h2uA-2h8hA:
36.2		 5h2uA-2h8hA:
26.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H2U_A_1N1A501_2
(PROTEIN-TYROSINE
KINASE 6)		 2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Homo
sapiens) 		3 / 3 ILE A 336
MET A 341
ASP A 404
 H8H  A 534 ( 4.5A)
None
H8H  A 534 (-4.2A)
 0.74A 5h2uA-2h8hA:
36.2		 5h2uA-2h8hA:
26.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H2U_B_1N1B501_1
(PROTEIN-TYROSINE
KINASE 6)		 2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Homo
sapiens) 		8 / 12 LEU A 273
VAL A 281
ALA A 293
ILE A 336
THR A 338
GLY A 344
LEU A 393
ASP A 404
 H8H  A 534 (-3.8A)
H8H  A 534 (-4.4A)
H8H  A 534 (-3.2A)
H8H  A 534 ( 4.5A)
H8H  A 534 (-3.1A)
H8H  A 534 (-3.3A)
H8H  A 534 (-4.5A)
H8H  A 534 (-4.2A)
 0.64A 5h2uB-2h8hA:
36.3		 5h2uB-2h8hA:
26.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H2U_C_1N1C501_1
(PROTEIN-TYROSINE
KINASE 6)		 2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Homo
sapiens) 		6 / 12 LEU A 273
ALA A 293
ILE A 336
THR A 338
GLY A 344
LEU A 393
 H8H  A 534 (-3.8A)
H8H  A 534 (-3.2A)
H8H  A 534 ( 4.5A)
H8H  A 534 (-3.1A)
H8H  A 534 (-3.3A)
H8H  A 534 (-4.5A)
 0.63A 5h2uC-2h8hA:
36.1		 5h2uC-2h8hA:
26.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H2U_C_1N1C501_1
(PROTEIN-TYROSINE
KINASE 6)		 2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Homo
sapiens) 		7 / 12 LEU A 273
ALA A 293
LYS A 295
ILE A 336
THR A 338
GLY A 344
ASP A 404
 H8H  A 534 (-3.8A)
H8H  A 534 (-3.2A)
H8H  A 534 (-3.7A)
H8H  A 534 ( 4.5A)
H8H  A 534 (-3.1A)
H8H  A 534 (-3.3A)
H8H  A 534 (-4.2A)
 0.77A 5h2uC-2h8hA:
36.1		 5h2uC-2h8hA:
26.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H2U_D_1N1D504_1
(PROTEIN-TYROSINE
KINASE 6)		 2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Homo
sapiens) 		8 / 12 LEU A 273
VAL A 281
ALA A 293
ILE A 336
THR A 338
GLY A 344
LEU A 393
ASP A 404
 H8H  A 534 (-3.8A)
H8H  A 534 (-4.4A)
H8H  A 534 (-3.2A)
H8H  A 534 ( 4.5A)
H8H  A 534 (-3.1A)
H8H  A 534 (-3.3A)
H8H  A 534 (-4.5A)
H8H  A 534 (-4.2A)
 0.57A 5h2uD-2h8hA:
36.4		 5h2uD-2h8hA:
26.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H2U_D_1N1D504_1
(PROTEIN-TYROSINE
KINASE 6)		 5vcx MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE
(Homo
sapiens) 		7 / 12 LEU A 116
VAL A 124
ALA A 137
THR A 187
LEU A 189
GLY A 250
ASP A 251
 H8H  A 401 (-3.7A)
H8H  A 401 (-4.7A)
H8H  A 401 (-3.3A)
H8H  A 401 (-3.5A)
None
None
EDO  A 402 ( 2.9A)
 0.65A 5h2uD-5vcxA:
17.1		 5h2uD-5vcxA:
25.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HES_A_032A401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLT)		 2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Homo
sapiens) 		6 / 12 ALA A 293
ILE A 336
THR A 338
ASP A 348
PHE A 405
GLY A 406
 H8H  A 534 (-3.2A)
H8H  A 534 ( 4.5A)
H8H  A 534 (-3.1A)
None
None
None
 0.88A 5hesA-2h8hA:
9.6		 5hesA-2h8hA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HES_A_032A401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLT)		 2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Homo
sapiens) 		7 / 12 VAL A 281
ALA A 293
ILE A 336
THR A 338
TYR A 340
ASP A 348
PHE A 405
 H8H  A 534 (-4.4A)
H8H  A 534 (-3.2A)
H8H  A 534 ( 4.5A)
H8H  A 534 (-3.1A)
H8H  A 534 (-4.3A)
None
None
 0.85A 5hesA-2h8hA:
9.6		 5hesA-2h8hA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HES_B_032B401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLT)		 2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Homo
sapiens) 		7 / 12 VAL A 281
ALA A 293
ILE A 336
THR A 338
ASP A 348
PHE A 405
GLY A 406
 H8H  A 534 (-4.4A)
H8H  A 534 (-3.2A)
H8H  A 534 ( 4.5A)
H8H  A 534 (-3.1A)
None
None
None
 0.80A 5hesB-2h8hA:
27.1		 5hesB-2h8hA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HES_B_032B401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLT)		 2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Homo
sapiens) 		7 / 12 VAL A 281
ALA A 293
ILE A 336
THR A 338
TYR A 340
ASP A 348
PHE A 405
 H8H  A 534 (-4.4A)
H8H  A 534 (-3.2A)
H8H  A 534 ( 4.5A)
H8H  A 534 (-3.1A)
H8H  A 534 (-4.3A)
None
None
 0.78A 5hesB-2h8hA:
27.1		 5hesB-2h8hA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HES_B_032B401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLT)		 2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Homo
sapiens) 		7 / 12 VAL A 281
ALA A 293
LYS A 295
ILE A 336
THR A 338
TYR A 340
PHE A 405
 H8H  A 534 (-4.4A)
H8H  A 534 (-3.2A)
H8H  A 534 (-3.7A)
H8H  A 534 ( 4.5A)
H8H  A 534 (-3.1A)
H8H  A 534 (-4.3A)
None
 0.66A 5hesB-2h8hA:
27.1		 5hesB-2h8hA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HI2_A_BAXA801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 5vcx MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE
(Homo
sapiens) 		7 / 12 ALA A 137
GLU A 157
THR A 187
CYH A 190
LEU A 224
HIS A 231
GLY A 250
 H8H  A 401 (-3.3A)
None
H8H  A 401 (-3.5A)
H8H  A 401 (-4.3A)
None
None
None
 0.71A 5hi2A-5vcxA:
22.3		 5hi2A-5vcxA:
26.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HI2_A_BAXA801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 5vcx MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE
(Homo
sapiens) 		7 / 12 ALA A 137
LYS A 139
GLU A 157
THR A 187
CYH A 190
HIS A 231
GLY A 250
 H8H  A 401 (-3.3A)
H8H  A 401 (-4.9A)
None
H8H  A 401 (-3.5A)
H8H  A 401 (-4.3A)
None
None
 0.80A 5hi2A-5vcxA:
22.3		 5hi2A-5vcxA:
26.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_A_P06A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Homo
sapiens) 		5 / 12 VAL A 281
ALA A 293
LYS A 295
ILE A 336
THR A 338
 H8H  A 534 (-4.4A)
H8H  A 534 (-3.2A)
H8H  A 534 (-3.7A)
H8H  A 534 ( 4.5A)
H8H  A 534 (-3.1A)
 0.45A 5hieA-2h8hA:
26.7		 5hieA-2h8hA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_A_P06A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 5vcx MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE
(Homo
sapiens) 		5 / 12 VAL A 124
ALA A 137
THR A 187
PHE A 240
GLY A 250
 H8H  A 401 (-4.7A)
H8H  A 401 (-3.3A)
H8H  A 401 (-3.5A)
H8H  A 401 (-4.3A)
None
 0.64A 5hieA-5vcxA:
7.0		 5hieA-5vcxA:
27.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_B_P06B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Homo
sapiens) 		5 / 12 VAL A 281
ALA A 293
LYS A 295
ILE A 336
THR A 338
 H8H  A 534 (-4.4A)
H8H  A 534 (-3.2A)
H8H  A 534 (-3.7A)
H8H  A 534 ( 4.5A)
H8H  A 534 (-3.1A)
 0.45A 5hieB-2h8hA:
26.7		 5hieB-2h8hA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_B_P06B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 5vcx MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE
(Homo
sapiens) 		5 / 12 VAL A 124
ALA A 137
THR A 187
PHE A 240
GLY A 250
 H8H  A 401 (-4.7A)
H8H  A 401 (-3.3A)
H8H  A 401 (-3.5A)
H8H  A 401 (-4.3A)
None
 0.66A 5hieB-5vcxA:
6.9		 5hieB-5vcxA:
27.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_C_P06C801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Homo
sapiens) 		5 / 12 GLY A 274
VAL A 281
ALA A 293
LYS A 295
THR A 338
 H8H  A 534 ( 3.8A)
H8H  A 534 (-4.4A)
H8H  A 534 (-3.2A)
H8H  A 534 (-3.7A)
H8H  A 534 (-3.1A)
 0.39A 5hieC-2h8hA:
26.4		 5hieC-2h8hA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_C_P06C801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 5vcx MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE
(Homo
sapiens) 		6 / 12 GLY A 117
VAL A 124
ALA A 137
THR A 187
PHE A 240
GLY A 250
 H8H  A 401 ( 3.7A)
H8H  A 401 (-4.7A)
H8H  A 401 (-3.3A)
H8H  A 401 (-3.5A)
H8H  A 401 (-4.3A)
None
 0.75A 5hieC-5vcxA:
21.2		 5hieC-5vcxA:
27.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_C_P06C801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 5vcx MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE
(Homo
sapiens) 		6 / 12 VAL A 124
ALA A 137
THR A 187
PHE A 240
GLY A 250
ASP A 251
 H8H  A 401 (-4.7A)
H8H  A 401 (-3.3A)
H8H  A 401 (-3.5A)
H8H  A 401 (-4.3A)
None
EDO  A 402 ( 2.9A)
 0.81A 5hieC-5vcxA:
21.2		 5hieC-5vcxA:
27.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_D_P06D801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Homo
sapiens) 		5 / 12 VAL A 281
ALA A 293
LYS A 295
ILE A 336
THR A 338
 H8H  A 534 (-4.4A)
H8H  A 534 (-3.2A)
H8H  A 534 (-3.7A)
H8H  A 534 ( 4.5A)
H8H  A 534 (-3.1A)
 0.44A 5hieD-2h8hA:
26.1		 5hieD-2h8hA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_D_P06D801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 5vcx MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE
(Homo
sapiens) 		5 / 12 VAL A 124
ALA A 137
THR A 187
PHE A 240
GLY A 250
 H8H  A 401 (-4.7A)
H8H  A 401 (-3.3A)
H8H  A 401 (-3.5A)
H8H  A 401 (-4.3A)
None
 0.65A 5hieD-5vcxA:
21.0		 5hieD-5vcxA:
27.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I9X_A_DB8A1001_1
(EPHRIN TYPE-A
RECEPTOR 2)		 2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Homo
sapiens) 		6 / 12 ALA A 293
ILE A 336
THR A 338
TYR A 340
GLY A 344
LEU A 393
 H8H  A 534 (-3.2A)
H8H  A 534 ( 4.5A)
H8H  A 534 (-3.1A)
H8H  A 534 (-4.3A)
H8H  A 534 (-3.3A)
H8H  A 534 (-4.5A)
 0.41A 5i9xA-2h8hA:
30.8		 5i9xA-2h8hA:
26.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I9Y_A_1N1A1001_1
(EPHRIN TYPE-A
RECEPTOR 2)		 2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Homo
sapiens) 		6 / 12 ALA A 293
LYS A 295
THR A 338
TYR A 340
GLY A 344
LEU A 393
 H8H  A 534 (-3.2A)
H8H  A 534 (-3.7A)
H8H  A 534 (-3.1A)
H8H  A 534 (-4.3A)
H8H  A 534 (-3.3A)
H8H  A 534 (-4.5A)
 0.48A 5i9yA-2h8hA:
30.4		 5i9yA-2h8hA:
26.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IZJ_F_AZ1F2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAR-DAR-DAR)		 2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Homo
sapiens) 		5 / 7 GLY A 274
GLY A 276
GLY A 279
VAL A 281
LEU A 297
 H8H  A 534 ( 3.8A)
None
None
H8H  A 534 (-4.4A)
None
 0.43A 5izjB-2h8hA:
21.4		 5izjB-2h8hA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IZJ_G_AZ1G2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAR-DAR)		 2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Homo
sapiens) 		4 / 7 GLY A 274
GLY A 276
VAL A 281
LEU A 297
 H8H  A 534 ( 3.8A)
None
H8H  A 534 (-4.4A)
None
 0.49A 5izjA-2h8hA:
21.7		 5izjA-2h8hA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IZJ_G_AZ1G2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAR-DAR)		 5vcx MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE
(Homo
sapiens) 		5 / 7 GLY A 117
GLY A 119
SER A 120
VAL A 124
LYS A 139
 H8H  A 401 ( 3.7A)
None
None
H8H  A 401 (-4.7A)
H8H  A 401 (-4.9A)
 0.80A 5izjA-5vcxA:
24.3		 5izjA-5vcxA:
26.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J5X_B_AZ1B2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAL-DAR-DAR-
DAR-DAR)		 5vcx MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE
(Homo
sapiens) 		5 / 7 GLY A 117
GLY A 119
SER A 120
VAL A 124
LYS A 139
 H8H  A 401 ( 3.7A)
None
None
H8H  A 401 (-4.7A)
H8H  A 401 (-4.9A)
 0.66A 5j5xA-5vcxA:
24.1		 5j5xA-5vcxA:
26.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2I_A_LQQA900_1
(CYCLIN-DEPENDENT
KINASE 6)		 2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Homo
sapiens) 		6 / 12 GLY A 274
VAL A 281
ALA A 293
VAL A 323
LEU A 393
ALA A 403
 H8H  A 534 ( 3.8A)
H8H  A 534 (-4.4A)
H8H  A 534 (-3.2A)
None
H8H  A 534 (-4.5A)
H8H  A 534 ( 4.0A)
 0.72A 5l2iA-2h8hA:
6.9		 5l2iA-2h8hA:
20.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5MO4_A_NILA601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Homo
sapiens) 		5 / 10 LEU A 273
VAL A 281
ILE A 336
MET A 341
GLY A 344
 H8H  A 534 (-3.8A)
H8H  A 534 (-4.4A)
H8H  A 534 ( 4.5A)
None
H8H  A 534 (-3.3A)
 0.64A 5mo4A-2h8hA:
38.3		 5mo4A-2h8hA:
40.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5MO4_A_NILA601_2
(TYROSINE-PROTEIN
KINASE ABL1)		 2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Homo
sapiens) 		6 / 12 ALA A 293
LEU A 322
VAL A 323
HIS A 384
LEU A 393
ALA A 403
 H8H  A 534 (-3.2A)
None
None
None
H8H  A 534 (-4.5A)
H8H  A 534 ( 4.0A)
 0.76A 5mo4A-2h8hA:
38.3		 5mo4A-2h8hA:
40.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N3H_A_NCAA401_0
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA)		 2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Homo
sapiens) 		6 / 10 LEU A 273
VAL A 281
ALA A 293
VAL A 323
TYR A 340
LEU A 393
 H8H  A 534 (-3.8A)
H8H  A 534 (-4.4A)
H8H  A 534 (-3.2A)
None
H8H  A 534 (-4.3A)
H8H  A 534 (-4.5A)
 0.76A 5n3hA-2h8hA:
22.2		 5n3hA-2h8hA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OWR_A_1N1A401_1
(SERINE/THREONINE-PRO
TEIN KINASE 10)		 5vcx MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE
(Homo
sapiens) 		4 / 8 ALA A 137
GLU A 157
CYH A 190
ASP A 251
 H8H  A 401 (-3.3A)
None
H8H  A 401 (-4.3A)
EDO  A 402 ( 2.9A)
 0.53A 5owrA-5vcxA:
15.2		 5owrA-5vcxA:
27.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5P9I_A_1E8A701_1
(TYROSINE-PROTEIN
KINASE BTK)		 2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Homo
sapiens) 		9 / 12 VAL A 281
ALA A 293
LYS A 295
MET A 314
ILE A 336
THR A 338
GLY A 344
LEU A 393
PHE A 405
 H8H  A 534 (-4.4A)
H8H  A 534 (-3.2A)
H8H  A 534 (-3.7A)
None
H8H  A 534 ( 4.5A)
H8H  A 534 (-3.1A)
H8H  A 534 (-3.3A)
H8H  A 534 (-4.5A)
None
 0.66A 5p9iA-2h8hA:
35.2		 5p9iA-2h8hA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5P9I_A_1E8A701_2
(TYROSINE-PROTEIN
KINASE BTK)		 2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Homo
sapiens) 		4 / 5 LEU A 273
TYR A 340
MET A 341
ASP A 404
 H8H  A 534 (-3.8A)
H8H  A 534 (-4.3A)
None
H8H  A 534 (-4.2A)
 0.62A 5p9iA-2h8hA:
35.2		 5p9iA-2h8hA:
22.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5VC3_A_DB8A601_1
(WEE1-LIKE PROTEIN
KINASE)		 5vcx MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE
(Homo
sapiens) 		6 / 12 ALA A 137
GLU A 157
CYH A 190
GLY A 191
PHE A 240
ASP A 251
 H8H  A 401 (-3.3A)
None
H8H  A 401 (-4.3A)
H8H  A 401 (-4.4A)
H8H  A 401 (-4.3A)
EDO  A 402 ( 2.9A)
 0.97A 5vc3A-5vcxA:
24.0		 5vc3A-5vcxA:
32.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5VC3_A_DB8A601_2
(WEE1-LIKE PROTEIN
KINASE)		 5vcx MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE
(Homo
sapiens) 		4 / 4 VAL A 124
LYS A 139
VAL A 171
ASN A 238
 H8H  A 401 (-4.7A)
H8H  A 401 (-4.9A)
None
EDO  A 402 (-3.9A)
 0.37A 5vc3A-5vcxA:
24.0		 5vc3A-5vcxA:
32.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5VCV_A_1N1A404_1
(MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE)		 5vcx MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE
(Homo
sapiens) 		12 / 12 LEU A 116
ALA A 137
LYS A 139
GLU A 157
VAL A 171
LEU A 185
THR A 187
GLY A 191
PRO A 192
GLN A 196
PHE A 240
GLY A 250
 H8H  A 401 (-3.7A)
H8H  A 401 (-3.3A)
H8H  A 401 (-4.9A)
None
None
H8H  A 401 (-4.3A)
H8H  A 401 (-3.5A)
H8H  A 401 (-4.4A)
H8H  A 401 ( 4.1A)
H8H  A 401 ( 4.4A)
H8H  A 401 (-4.3A)
None
 0.59A 5vcvA-5vcxA:
43.9		 5vcvA-5vcxA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5VCV_A_1N1A404_2
(MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE)		 5vcx MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE
(Homo
sapiens) 		5 / 5 VAL A 124
HIS A 161
LEU A 189
CYH A 190
ASP A 251
 H8H  A 401 (-4.7A)
None
None
H8H  A 401 (-4.3A)
EDO  A 402 ( 2.9A)
 0.50A 5vcvA-5vcxA:
44.0		 5vcvA-5vcxA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5VCY_A_DB8A401_1
(MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE)		 5vcx MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE
(Homo
sapiens) 		12 / 12 LEU A 116
VAL A 124
ALA A 137
LYS A 139
GLU A 157
LEU A 185
THR A 187
CYH A 190
GLY A 191
PRO A 192
GLN A 196
PHE A 240
 H8H  A 401 (-3.7A)
H8H  A 401 (-4.7A)
H8H  A 401 (-3.3A)
H8H  A 401 (-4.9A)
None
H8H  A 401 (-4.3A)
H8H  A 401 (-3.5A)
H8H  A 401 (-4.3A)
H8H  A 401 (-4.4A)
H8H  A 401 ( 4.1A)
H8H  A 401 ( 4.4A)
H8H  A 401 (-4.3A)
 0.53A 5vcyA-5vcxA:
42.4		 5vcyA-5vcxA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XV7_A_EMHA705_1
(SERINE-ARGININE (SR)
PROTEIN KINASE 1)		 2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Homo
sapiens) 		5 / 12 LEU A 273
GLY A 274
VAL A 281
ALA A 293
ALA A 403
 H8H  A 534 (-3.8A)
H8H  A 534 ( 3.8A)
H8H  A 534 (-4.4A)
H8H  A 534 (-3.2A)
H8H  A 534 ( 4.0A)
 0.56A 5xv7A-2h8hA:
21.1		 5xv7A-2h8hA:
11.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XV7_A_EMHA705_1
(SERINE-ARGININE (SR)
PROTEIN KINASE 1)		 2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Homo
sapiens) 		5 / 12 LEU A 273
GLY A 274
VAL A 281
GLY A 344
ALA A 403
 H8H  A 534 (-3.8A)
H8H  A 534 ( 3.8A)
H8H  A 534 (-4.4A)
H8H  A 534 (-3.3A)
H8H  A 534 ( 4.0A)
 0.70A 5xv7A-2h8hA:
21.1		 5xv7A-2h8hA:
11.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7Z_A_IREA401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 5vcx MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE
(Homo
sapiens) 		7 / 12 LEU A 116
VAL A 124
ALA A 137
LYS A 139
GLU A 157
LEU A 189
CYH A 190
 H8H  A 401 (-3.7A)
H8H  A 401 (-4.7A)
H8H  A 401 (-3.3A)
H8H  A 401 (-4.9A)
None
None
H8H  A 401 (-4.3A)
 0.44A 5y7zA-5vcxA:
23.4		 5y7zA-5vcxA:
14.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7Z_A_IREA401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 5vcx MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE
(Homo
sapiens) 		7 / 12 LEU A 116
VAL A 124
ALA A 137
LYS A 139
GLU A 157
LEU A 189
CYH A 190
 H8H  A 401 (-3.7A)
H8H  A 401 (-4.7A)
H8H  A 401 (-3.3A)
H8H  A 401 (-4.9A)
None
None
H8H  A 401 (-4.3A)
 0.44A 5y7zA-5vcxA:
23.4		 5y7zA-5vcxA:
26.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7Z_A_IREA401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 5vcx MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE
(Homo
sapiens) 		7 / 12 VAL A 124
ALA A 137
LYS A 139
GLU A 157
LEU A 189
CYH A 190
GLY A 191
 H8H  A 401 (-4.7A)
H8H  A 401 (-3.3A)
H8H  A 401 (-4.9A)
None
None
H8H  A 401 (-4.3A)
H8H  A 401 (-4.4A)
 0.95A 5y7zA-5vcxA:
23.4		 5y7zA-5vcxA:
14.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7Z_A_IREA401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 5vcx MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE
(Homo
sapiens) 		7 / 12 VAL A 124
ALA A 137
LYS A 139
GLU A 157
LEU A 189
CYH A 190
GLY A 191
 H8H  A 401 (-4.7A)
H8H  A 401 (-3.3A)
H8H  A 401 (-4.9A)
None
None
H8H  A 401 (-4.3A)
H8H  A 401 (-4.4A)
 0.95A 5y7zA-5vcxA:
23.4		 5y7zA-5vcxA:
26.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7Z_B_IREB401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 5vcx MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE
(Homo
sapiens) 		8 / 12 LEU A 116
ALA A 137
GLU A 157
LEU A 185
LEU A 189
CYH A 190
GLY A 191
ASP A 251
 H8H  A 401 (-3.7A)
H8H  A 401 (-3.3A)
None
H8H  A 401 (-4.3A)
None
H8H  A 401 (-4.3A)
H8H  A 401 (-4.4A)
EDO  A 402 ( 2.9A)
 0.89A 5y7zB-5vcxA:
23.5		 5y7zB-5vcxA:
14.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7Z_B_IREB401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 5vcx MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE
(Homo
sapiens) 		8 / 12 LEU A 116
ALA A 137
LYS A 139
GLU A 157
LEU A 185
LEU A 189
CYH A 190
GLY A 191
 H8H  A 401 (-3.7A)
H8H  A 401 (-3.3A)
H8H  A 401 (-4.9A)
None
H8H  A 401 (-4.3A)
None
H8H  A 401 (-4.3A)
H8H  A 401 (-4.4A)
 0.99A 5y7zB-5vcxA:
23.5		 5y7zB-5vcxA:
14.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y80_A_IREA401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Homo
sapiens) 		7 / 12 LEU A 273
VAL A 281
ALA A 293
THR A 338
GLY A 344
LEU A 393
ASP A 404
 H8H  A 534 (-3.8A)
H8H  A 534 (-4.4A)
H8H  A 534 (-3.2A)
H8H  A 534 (-3.1A)
H8H  A 534 (-3.3A)
H8H  A 534 (-4.5A)
H8H  A 534 (-4.2A)
 0.63A 5y80A-2h8hA:
21.7		 5y80A-2h8hA:
11.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y80_A_IREA401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 5vcx MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE
(Homo
sapiens) 		9 / 12 LEU A 116
VAL A 124
ALA A 137
GLU A 157
THR A 187
LEU A 189
CYH A 190
GLY A 191
ASP A 251
 H8H  A 401 (-3.7A)
H8H  A 401 (-4.7A)
H8H  A 401 (-3.3A)
None
H8H  A 401 (-3.5A)
None
H8H  A 401 (-4.3A)
H8H  A 401 (-4.4A)
EDO  A 402 ( 2.9A)
 0.82A 5y80A-5vcxA:
22.7		 5y80A-5vcxA:
14.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y80_A_IREA401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 5vcx MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE
(Homo
sapiens) 		9 / 12 LEU A 116
VAL A 124
ALA A 137
LYS A 139
GLU A 157
THR A 187
LEU A 189
CYH A 190
GLY A 191
 H8H  A 401 (-3.7A)
H8H  A 401 (-4.7A)
H8H  A 401 (-3.3A)
H8H  A 401 (-4.9A)
None
H8H  A 401 (-3.5A)
None
H8H  A 401 (-4.3A)
H8H  A 401 (-4.4A)
 0.93A 5y80A-5vcxA:
22.7		 5y80A-5vcxA:
14.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YU9_A_1E8A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Homo
sapiens) 		8 / 12 LEU A 273
GLY A 274
VAL A 281
ALA A 293
LYS A 295
MET A 314
LEU A 393
ASP A 404
 H8H  A 534 (-3.8A)
H8H  A 534 ( 3.8A)
H8H  A 534 (-4.4A)
H8H  A 534 (-3.2A)
H8H  A 534 (-3.7A)
None
H8H  A 534 (-4.5A)
H8H  A 534 (-4.2A)
 0.65A 5yu9A-2h8hA:
32.7		 5yu9A-2h8hA:
12.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YU9_B_1E8B1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Homo
sapiens) 		8 / 12 GLY A 274
VAL A 281
ALA A 293
LYS A 295
MET A 314
ASP A 348
LEU A 393
ASP A 404
 H8H  A 534 ( 3.8A)
H8H  A 534 (-4.4A)
H8H  A 534 (-3.2A)
H8H  A 534 (-3.7A)
None
None
H8H  A 534 (-4.5A)
H8H  A 534 (-4.2A)
 0.70A 5yu9B-2h8hA:
32.7		 5yu9B-2h8hA:
12.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YU9_C_1E8C1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Homo
sapiens) 		7 / 12 VAL A 281
ALA A 293
LYS A 295
MET A 314
GLY A 344
ASP A 348
ASP A 404
 H8H  A 534 (-4.4A)
H8H  A 534 (-3.2A)
H8H  A 534 (-3.7A)
None
H8H  A 534 (-3.3A)
None
H8H  A 534 (-4.2A)
 0.70A 5yu9C-2h8hA:
32.1		 5yu9C-2h8hA:
12.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YU9_D_1E8D1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Homo
sapiens) 		9 / 12 VAL A 281
ALA A 293
LYS A 295
MET A 314
GLY A 344
ASP A 348
LEU A 393
ASP A 404
LEU A 407
 H8H  A 534 (-4.4A)
H8H  A 534 (-3.2A)
H8H  A 534 (-3.7A)
None
H8H  A 534 (-3.3A)
None
H8H  A 534 (-4.5A)
H8H  A 534 (-4.2A)
None
 0.81A 5yu9D-2h8hA:
32.4		 5yu9D-2h8hA:
12.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		 2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Homo
sapiens) 		6 / 12 LEU A 273
VAL A 281
ALA A 293
TYR A 340
GLY A 344
ALA A 403
 H8H  A 534 (-3.8A)
H8H  A 534 (-4.4A)
H8H  A 534 (-3.2A)
H8H  A 534 (-4.3A)
H8H  A 534 (-3.3A)
H8H  A 534 ( 4.0A)
 0.63A 5zv2A-2h8hA:
29.6		 5zv2A-2h8hA:
9.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		 2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Homo
sapiens) 		3 / 3 TYR A 340
LEU A 393
ASP A 404
 H8H  A 534 (-4.3A)
H8H  A 534 (-4.5A)
H8H  A 534 (-4.2A)
 0.62A 5zv2B-2h8hA:
29.4		 5zv2B-2h8hA:
9.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSD_A_1N1A901_0
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Homo
sapiens) 		7 / 12 VAL A 281
ALA A 293
LYS A 295
THR A 338
TYR A 340
MET A 341
LEU A 393
 H8H  A 534 (-4.4A)
H8H  A 534 (-3.2A)
H8H  A 534 (-3.7A)
H8H  A 534 (-3.1A)
H8H  A 534 (-4.3A)
None
H8H  A 534 (-4.5A)
 0.59A 6bsdA-2h8hA:
28.9		 6bsdA-2h8hA:
8.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSD_A_1N1A901_0
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Homo
sapiens) 		7 / 12 VAL A 281
ALA A 293
THR A 338
TYR A 340
MET A 341
GLY A 344
LEU A 393
 H8H  A 534 (-4.4A)
H8H  A 534 (-3.2A)
H8H  A 534 (-3.1A)
H8H  A 534 (-4.3A)
None
H8H  A 534 (-3.3A)
H8H  A 534 (-4.5A)
 0.40A 6bsdA-2h8hA:
28.9		 6bsdA-2h8hA:
8.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FNM_A_1N1A1001_1
(-)		 2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Homo
sapiens) 		8 / 12 VAL A 281
ALA A 293
LYS A 295
ILE A 336
THR A 338
MET A 341
GLY A 344
LEU A 393
 H8H  A 534 (-4.4A)
H8H  A 534 (-3.2A)
H8H  A 534 (-3.7A)
H8H  A 534 ( 4.5A)
H8H  A 534 (-3.1A)
None
H8H  A 534 (-3.3A)
H8H  A 534 (-4.5A)
 0.50A 6fnmA-2h8hA:
30.8		 6fnmA-2h8hA:
26.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD4_A_STIA604_0
(TYROSINE-PROTEIN
KINASE ABL1)		 2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Homo
sapiens) 		6 / 12 VAL A 281
ALA A 293
LYS A 295
VAL A 323
ILE A 336
THR A 338
 H8H  A 534 (-4.4A)
H8H  A 534 (-3.2A)
H8H  A 534 (-3.7A)
None
H8H  A 534 ( 4.5A)
H8H  A 534 (-3.1A)
 0.58A 6hd4A-2h8hA:
29.7		 6hd4A-2h8hA:
9.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD4_A_STIA604_0
(TYROSINE-PROTEIN
KINASE ABL1)		 2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Homo
sapiens) 		7 / 12 VAL A 281
ALA A 293
VAL A 323
ILE A 336
THR A 338
LEU A 393
ALA A 403
 H8H  A 534 (-4.4A)
H8H  A 534 (-3.2A)
None
H8H  A 534 ( 4.5A)
H8H  A 534 (-3.1A)
H8H  A 534 (-4.5A)
H8H  A 534 ( 4.0A)
 0.92A 6hd4A-2h8hA:
29.7		 6hd4A-2h8hA:
9.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD4_B_STIB602_0
(TYROSINE-PROTEIN
KINASE ABL1)		 2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Homo
sapiens) 		7 / 12 VAL A 281
ALA A 293
VAL A 323
ILE A 336
THR A 338
LEU A 393
ALA A 403
 H8H  A 534 (-4.4A)
H8H  A 534 (-3.2A)
None
H8H  A 534 ( 4.5A)
H8H  A 534 (-3.1A)
H8H  A 534 (-4.5A)
H8H  A 534 ( 4.0A)
 0.89A 6hd4B-2h8hA:
30.0		 6hd4B-2h8hA:
9.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD6_A_STIA603_0
(TYROSINE-PROTEIN
KINASE ABL1)		 2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Homo
sapiens) 		7 / 12 VAL A 281
ALA A 293
VAL A 323
ILE A 336
THR A 338
LEU A 393
ALA A 403
 H8H  A 534 (-4.4A)
H8H  A 534 (-3.2A)
None
H8H  A 534 ( 4.5A)
H8H  A 534 (-3.1A)
H8H  A 534 (-4.5A)
H8H  A 534 ( 4.0A)
 0.90A 6hd6A-2h8hA:
29.7		 6hd6A-2h8hA:
9.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD6_B_STIB601_0
(TYROSINE-PROTEIN
KINASE ABL1)		 5vcx MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE
(Homo
sapiens) 		7 / 12 LEU A 116
VAL A 124
ALA A 137
LYS A 139
GLU A 157
VAL A 171
THR A 187
 H8H  A 401 (-3.7A)
H8H  A 401 (-4.7A)
H8H  A 401 (-3.3A)
H8H  A 401 (-4.9A)
None
None
H8H  A 401 (-3.5A)
 0.71A 6hd6B-5vcxA:
17.5		 6hd6B-5vcxA:
13.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD6_B_STIB601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Homo
sapiens) 		4 / 7 ILE A 336
MET A 341
GLY A 344
ALA A 403
 H8H  A 534 ( 4.5A)
None
H8H  A 534 (-3.3A)
H8H  A 534 ( 4.0A)
 0.75A 6hd6B-2h8hA:
29.9		 6hd6B-2h8hA:
9.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD6_B_STIB601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Homo
sapiens) 		4 / 7 MET A 341
GLY A 344
ARG A 385
ALA A 403
 None
H8H  A 534 (-3.3A)
None
H8H  A 534 ( 4.0A)
 0.48A 6hd6B-2h8hA:
29.9		 6hd6B-2h8hA:
9.51