SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'H33'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T7I_A_017A200_2
(POL POLYPROTEIN)		 2uy3 ENDOCHITINASE
(Saccharomyces
cerevisiae) 		4 / 7 ASP A 155
ASP A 286
GLY A 247
ILE A 211
 H33  A1311 (-3.0A)
None
None
None
 0.83A 1t7iB-2uy3A:
undetectable		 1t7iB-2uy3A:
15.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T7J_A_478A200_2
(POL POLYPROTEIN)		 2uy3 ENDOCHITINASE
(Saccharomyces
cerevisiae) 		4 / 7 ASP A 155
ASP A 286
GLY A 247
ILE A 211
 H33  A1311 (-3.0A)
None
None
None
 0.80A 1t7jB-2uy3A:
undetectable		 1t7jB-2uy3A:
15.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3A_A_TEPA1433_1
(CHITINASE)		 2uy3 ENDOCHITINASE
(Saccharomyces
cerevisiae) 		6 / 11 TYR A  32
PHE A  60
GLY A 109
GLU A 157
TYR A 214
TRP A 285
 H33  A1311 ( 4.2A)
H33  A1311 (-4.3A)
H33  A1311 ( 3.8A)
H33  A1311 (-3.7A)
H33  A1311 (-4.7A)
H33  A1311 (-3.5A)
 0.62A 2a3aA-2uy3A:
20.2		 2a3aA-2uy3A:
25.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3A_B_TEPB2433_1
(CHITINASE)		 2uy3 ENDOCHITINASE
(Saccharomyces
cerevisiae) 		5 / 9 PHE A  60
GLY A 109
GLU A 157
TYR A 214
TRP A 285
 H33  A1311 (-4.3A)
H33  A1311 ( 3.8A)
H33  A1311 (-3.7A)
H33  A1311 (-4.7A)
H33  A1311 (-3.5A)
 0.66A 2a3aB-2uy3A:
20.3		 2a3aB-2uy3A:
25.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3B_B_CFFB2435_1
(CHITINASE)		 2uy3 ENDOCHITINASE
(Saccharomyces
cerevisiae) 		6 / 10 PHE A  60
GLY A 109
ASP A 155
GLU A 157
TYR A 214
TRP A 285
 H33  A1311 (-4.3A)
H33  A1311 ( 3.8A)
H33  A1311 (-3.0A)
H33  A1311 (-3.7A)
H33  A1311 (-4.7A)
H33  A1311 (-3.5A)
 1.14A 2a3bB-2uy3A:
20.2		 2a3bB-2uy3A:
25.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3C_A_PNXA1434_1
(CHITINASE)		 2uy3 ENDOCHITINASE
(Saccharomyces
cerevisiae) 		7 / 12 TYR A  32
PHE A  60
GLY A 109
ASP A 155
GLU A 157
TYR A 214
TRP A 285
 H33  A1311 ( 4.2A)
H33  A1311 (-4.3A)
H33  A1311 ( 3.8A)
H33  A1311 (-3.0A)
H33  A1311 (-3.7A)
H33  A1311 (-4.7A)
H33  A1311 (-3.5A)
 1.14A 2a3cA-2uy3A:
20.2		 2a3cA-2uy3A:
25.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3C_B_PNXB2433_1
(CHITINASE)		 2uy3 ENDOCHITINASE
(Saccharomyces
cerevisiae) 		6 / 12 PHE A  60
GLY A 109
ASP A 155
GLU A 157
TYR A 214
TRP A 285
 H33  A1311 (-4.3A)
H33  A1311 ( 3.8A)
H33  A1311 (-3.0A)
H33  A1311 (-3.7A)
H33  A1311 (-4.7A)
H33  A1311 (-3.5A)
 1.14A 2a3cB-2uy3A:
20.2		 2a3cB-2uy3A:
25.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2UY4_A_AZMA1311_1
(ENDOCHITINASE)		 2uy3 ENDOCHITINASE
(Saccharomyces
cerevisiae) 		9 / 9 TYR A  32
PHE A  60
GLY A 109
ALA A 110
ASP A 155
GLU A 157
GLN A 212
TYR A 214
TRP A 285
 H33  A1311 ( 4.2A)
H33  A1311 (-4.3A)
H33  A1311 ( 3.8A)
H33  A1311 (-3.5A)
H33  A1311 (-3.0A)
H33  A1311 (-3.7A)
H33  A1311 (-3.3A)
H33  A1311 (-4.7A)
H33  A1311 (-3.5A)
 0.20A 2uy4A-2uy3A:
52.5		 2uy4A-2uy3A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2XTK_A_AZMA1339_1
(CLASS III CHITINASE
CHIA1)		 2uy3 ENDOCHITINASE
(Saccharomyces
cerevisiae) 		6 / 11 GLY A 109
ALA A 110
GLU A 157
GLN A 189
ASN A 215
ALA A 255
 H33  A1311 ( 3.8A)
H33  A1311 (-3.5A)
H33  A1311 (-3.7A)
None
None
H33  A1311 ( 4.6A)
 1.38A 2xtkA-2uy3A:
40.6		 2xtkA-2uy3A:
42.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2XTK_A_AZMA1339_1
(CLASS III CHITINASE
CHIA1)		 2uy3 ENDOCHITINASE
(Saccharomyces
cerevisiae) 		7 / 11 TYR A  32
PHE A  60
GLY A 109
ALA A 110
ASP A 155
ALA A 254
TRP A 285
 H33  A1311 ( 4.2A)
H33  A1311 (-4.3A)
H33  A1311 ( 3.8A)
H33  A1311 (-3.5A)
H33  A1311 (-3.0A)
None
H33  A1311 (-3.5A)
 1.14A 2xtkA-2uy3A:
40.6		 2xtkA-2uy3A:
42.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2XTK_A_AZMA1339_1
(CLASS III CHITINASE
CHIA1)		 2uy3 ENDOCHITINASE
(Saccharomyces
cerevisiae) 		11 / 11 TYR A  32
PHE A  60
GLY A 109
ALA A 110
ASP A 155
GLU A 157
GLN A 212
TYR A 214
ASN A 215
ALA A 255
TRP A 285
 H33  A1311 ( 4.2A)
H33  A1311 (-4.3A)
H33  A1311 ( 3.8A)
H33  A1311 (-3.5A)
H33  A1311 (-3.0A)
H33  A1311 (-3.7A)
H33  A1311 (-3.3A)
H33  A1311 (-4.7A)
None
H33  A1311 ( 4.6A)
H33  A1311 (-3.5A)
 0.43A 2xtkA-2uy3A:
40.6		 2xtkA-2uy3A:
42.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2XTK_B_AZMB1339_1
(CLASS III CHITINASE
CHIA1)		 2uy3 ENDOCHITINASE
(Saccharomyces
cerevisiae) 		9 / 10 TYR A  32
PHE A  60
GLY A 109
ALA A 110
ASP A 155
GLU A 157
GLN A 212
TYR A 214
TRP A 285
 H33  A1311 ( 4.2A)
H33  A1311 (-4.3A)
H33  A1311 ( 3.8A)
H33  A1311 (-3.5A)
H33  A1311 (-3.0A)
H33  A1311 (-3.7A)
H33  A1311 (-3.3A)
H33  A1311 (-4.7A)
H33  A1311 (-3.5A)
 0.33A 2xtkB-2uy3A:
40.5		 2xtkB-2uy3A:
42.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G6M_A_CFFA1_1
(CHITINASE)		 2uy3 ENDOCHITINASE
(Saccharomyces
cerevisiae) 		6 / 11 TYR A  32
PHE A  60
GLY A 109
ASP A 155
TYR A 214
TRP A 285
 H33  A1311 ( 4.2A)
H33  A1311 (-4.3A)
H33  A1311 ( 3.8A)
H33  A1311 (-3.0A)
H33  A1311 (-4.7A)
H33  A1311 (-3.5A)
 0.98A 3g6mA-2uy3A:
20.3		 3g6mA-2uy3A:
25.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G6M_A_CFFA1_1
(CHITINASE)		 2uy3 ENDOCHITINASE
(Saccharomyces
cerevisiae) 		6 / 11 TYR A  32
PHE A  60
GLY A 109
GLU A 157
TYR A 214
TRP A 285
 H33  A1311 ( 4.2A)
H33  A1311 (-4.3A)
H33  A1311 ( 3.8A)
H33  A1311 (-3.7A)
H33  A1311 (-4.7A)
H33  A1311 (-3.5A)
 0.66A 3g6mA-2uy3A:
20.3		 3g6mA-2uy3A:
25.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_C_SAMC300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 2uy3 ENDOCHITINASE
(Saccharomyces
cerevisiae) 		5 / 12 TYR A 214
ALA A 254
GLY A 256
SER A 257
ALA A 290
 H33  A1311 (-4.7A)
None
None
None
None
 1.14A 3ou6C-2uy3A:
undetectable		 3ou6C-2uy3A:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_C_SAMC300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 2uy3 ENDOCHITINASE
(Saccharomyces
cerevisiae) 		5 / 12 TYR A 214
ALA A 254
GLY A 256
SER A 257
ALA A 290
 H33  A1311 (-4.7A)
None
None
None
None
 1.16A 3ou7C-2uy3A:
undetectable		 3ou7C-2uy3A:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WQV_A_GCSA501_1
(CHITINASE)		 2uy3 ENDOCHITINASE
(Saccharomyces
cerevisiae) 		6 / 11 PHE A  60
GLY A 109
ASP A 155
GLU A 157
TYR A 214
TRP A 285
 H33  A1311 (-4.3A)
H33  A1311 ( 3.8A)
H33  A1311 (-3.0A)
H33  A1311 (-3.7A)
H33  A1311 (-4.7A)
H33  A1311 (-3.5A)
 0.56A 3wqvA-2uy3A:
20.0		 3wqvA-2uy3A:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WQW_A_GCSA501_1
(CHITINASE)		 2uy3 ENDOCHITINASE
(Saccharomyces
cerevisiae) 		6 / 11 PHE A  60
GLY A 109
ASP A 155
GLU A 157
TYR A 214
TRP A 285
 H33  A1311 (-4.3A)
H33  A1311 ( 3.8A)
H33  A1311 (-3.0A)
H33  A1311 (-3.7A)
H33  A1311 (-4.7A)
H33  A1311 (-3.5A)
 0.58A 3wqwA-2uy3A:
20.1		 3wqwA-2uy3A:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GQB_A_GCSA603_1
(CHITINASE)		 2uy3 ENDOCHITINASE
(Saccharomyces
cerevisiae) 		5 / 8 PHE A  60
GLY A 109
GLU A 157
TYR A 214
TRP A 285
 H33  A1311 (-4.3A)
H33  A1311 ( 3.8A)
H33  A1311 (-3.7A)
H33  A1311 (-4.7A)
H33  A1311 (-3.5A)
 0.60A 5gqbA-2uy3A:
18.7		 5gqbA-2uy3A:
19.35