SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'H2U'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA501_1
(CYTOCHROME P450 2B4)		 2v0j BIFUNCTIONAL PROTEIN
GLMU
(Haemophilus
influenzae) 		4 / 7 SER A  21
MET A  19
GLY A  14
ILE A  10
 None
None
H2U  A1453 ( 3.4A)
None
 1.09A 2bdmA-2v0jA:
undetectable		 2bdmA-2v0jA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWX_A_EPAA1_1
(PROTEIN (PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
(PPAR-DELTA)))		 2v0j BIFUNCTIONAL PROTEIN
GLMU
(Haemophilus
influenzae) 		5 / 10 ILE A 109
LEU A  11
VAL A   9
VAL A  86
LEU A 198
 None
H2U  A1453 (-4.0A)
None
None
None
 0.89A 3gwxA-2v0jA:
undetectable		 3gwxA-2v0jA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SXJ_A_SAMA258_0
(PUTATIVE
METHYLTRANSFERASE)		 2v0j BIFUNCTIONAL PROTEIN
GLMU
(Haemophilus
influenzae) 		5 / 12 GLY A  16
GLY A  14
LEU A  23
SER A  21
MET A  19
 SO4  A1462 (-3.4A)
H2U  A1453 ( 3.4A)
None
None
None
 1.25A 3sxjA-2v0jA:
undetectable		 3sxjA-2v0jA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SXJ_B_SAMB258_0
(PUTATIVE
METHYLTRANSFERASE)		 2v0j BIFUNCTIONAL PROTEIN
GLMU
(Haemophilus
influenzae) 		5 / 12 GLY A  16
GLY A  14
LEU A  23
SER A  21
MET A  19
 SO4  A1462 (-3.4A)
H2U  A1453 ( 3.4A)
None
None
None
 1.26A 3sxjB-2v0jA:
undetectable		 3sxjB-2v0jA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_D_AERD601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 2v0j BIFUNCTIONAL PROTEIN
GLMU
(Haemophilus
influenzae) 		4 / 5 TYR A 139
GLY A 225
ASP A 105
VAL A 100
 None
None
H2U  A1453 (-2.7A)
None
 1.15A 4nkvD-2v0jA:
undetectable		 4nkvD-2v0jA:
23.58