SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'H1V'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U5J_A_08HA1_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 6dne BROMODOMAIN-CONTAINI
NG PROTEIN 4
(Homo
sapiens) 		7 / 7 TRP A  81
PRO A  82
LEU A  92
LEU A  94
ASN A 140
ILE A 146
MET A 149
 None
H1V  A 501 (-4.6A)
H1V  A 501 (-4.2A)
H1V  A 501 (-4.7A)
H1V  A 501 (-3.2A)
H1V  A 501 (-3.8A)
H1V  A 501 ( 3.8A)
 0.42A 3u5jA-6dneA:
23.4		 3u5jA-6dneA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U5K_A_08JA1_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 6dne BROMODOMAIN-CONTAINI
NG PROTEIN 4
(Homo
sapiens) 		8 / 8 TRP A  81
PRO A  82
VAL A  87
LEU A  92
LEU A  94
ASN A 140
ILE A 146
MET A 149
 None
H1V  A 501 (-4.6A)
H1V  A 501 ( 4.4A)
H1V  A 501 (-4.2A)
H1V  A 501 (-4.7A)
H1V  A 501 (-3.2A)
H1V  A 501 (-3.8A)
H1V  A 501 ( 3.8A)
 0.36A 3u5kA-6dneA:
24.0		 3u5kA-6dneA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U5K_B_08JB2_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 6dne BROMODOMAIN-CONTAINI
NG PROTEIN 4
(Homo
sapiens) 		7 / 7 TRP A  81
PRO A  82
VAL A  87
LEU A  92
LEU A  94
ASN A 140
ILE A 146
 None
H1V  A 501 (-4.6A)
H1V  A 501 ( 4.4A)
H1V  A 501 (-4.2A)
H1V  A 501 (-4.7A)
H1V  A 501 (-3.2A)
H1V  A 501 (-3.8A)
 0.48A 3u5kB-6dneA:
23.9		 3u5kB-6dneA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U5K_C_08JC3_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 6dne BROMODOMAIN-CONTAINI
NG PROTEIN 4
(Homo
sapiens) 		8 / 8 TRP A  81
PRO A  82
VAL A  87
LEU A  92
LEU A  94
ASN A 140
ILE A 146
MET A 149
 None
H1V  A 501 (-4.6A)
H1V  A 501 ( 4.4A)
H1V  A 501 (-4.2A)
H1V  A 501 (-4.7A)
H1V  A 501 (-3.2A)
H1V  A 501 (-3.8A)
H1V  A 501 ( 3.8A)
 0.45A 3u5kC-6dneA:
23.5		 3u5kC-6dneA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U5K_D_08JD4_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 6dne BROMODOMAIN-CONTAINI
NG PROTEIN 4
(Homo
sapiens) 		8 / 8 TRP A  81
PRO A  82
VAL A  87
LEU A  92
LEU A  94
ASN A 140
ILE A 146
MET A 149
 None
H1V  A 501 (-4.6A)
H1V  A 501 ( 4.4A)
H1V  A 501 (-4.2A)
H1V  A 501 (-4.7A)
H1V  A 501 (-3.2A)
H1V  A 501 (-3.8A)
H1V  A 501 ( 3.8A)
 0.50A 3u5kD-6dneA:
23.4		 3u5kD-6dneA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A9J_A_TYLA1188_1
(BROMODOMAIN
CONTAINING 2)		 6dne BROMODOMAIN-CONTAINI
NG PROTEIN 4
(Homo
sapiens) 		5 / 5 VAL A  87
LEU A  92
LEU A  94
ASN A 140
ILE A 146
 H1V  A 501 ( 4.4A)
H1V  A 501 (-4.2A)
H1V  A 501 (-4.7A)
H1V  A 501 (-3.2A)
H1V  A 501 (-3.8A)
 0.49A 4a9jA-6dneA:
20.0		 4a9jA-6dneA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A9J_B_TYLB1187_1
(BROMODOMAIN
CONTAINING 2)		 6dne BROMODOMAIN-CONTAINI
NG PROTEIN 4
(Homo
sapiens) 		5 / 5 VAL A  87
LEU A  92
LEU A  94
ASN A 140
ILE A 146
 H1V  A 501 ( 4.4A)
H1V  A 501 (-4.2A)
H1V  A 501 (-4.7A)
H1V  A 501 (-3.2A)
H1V  A 501 (-3.8A)
 0.45A 4a9jB-6dneA:
20.5		 4a9jB-6dneA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A9J_C_TYLC1184_1
(BROMODOMAIN
CONTAINING 2)		 6dne BROMODOMAIN-CONTAINI
NG PROTEIN 4
(Homo
sapiens) 		5 / 5 VAL A  87
LEU A  92
LEU A  94
ASN A 140
ILE A 146
 H1V  A 501 ( 4.4A)
H1V  A 501 (-4.2A)
H1V  A 501 (-4.7A)
H1V  A 501 (-3.2A)
H1V  A 501 (-3.8A)
 0.40A 4a9jC-6dneA:
19.8		 4a9jC-6dneA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A9K_A_TYLA2200_1
(CREB-BINDING PROTEIN)		 6dne BROMODOMAIN-CONTAINI
NG PROTEIN 4
(Homo
sapiens) 		4 / 6 VAL A  87
LEU A  92
TYR A 139
ASN A 140
 H1V  A 501 ( 4.4A)
H1V  A 501 (-4.2A)
None
H1V  A 501 (-3.2A)
 0.57A 4a9kA-6dneA:
16.6		 4a9kA-6dneA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C66_A_H4CA1168_0
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 6dne BROMODOMAIN-CONTAINI
NG PROTEIN 4
(Homo
sapiens) 		9 / 9 TRP A  81
PRO A  82
GLN A  85
VAL A  87
LEU A  92
LEU A  94
ASN A 140
ILE A 146
MET A 149
 None
H1V  A 501 (-4.6A)
H1V  A 501 ( 4.5A)
H1V  A 501 ( 4.4A)
H1V  A 501 (-4.2A)
H1V  A 501 (-4.7A)
H1V  A 501 (-3.2A)
H1V  A 501 (-3.8A)
H1V  A 501 ( 3.8A)
 0.52A 4c66A-6dneA:
23.4		 4c66A-6dneA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5PBE_A_TYLA2001_1
(BROMODOMAIN ADJACENT
TO ZINC FINGER
DOMAIN PROTEIN 2B)		 6dne BROMODOMAIN-CONTAINI
NG PROTEIN 4
(Homo
sapiens) 		4 / 6 PRO A  82
VAL A  87
TYR A  97
ILE A 146
 H1V  A 501 (-4.6A)
H1V  A 501 ( 4.4A)
None
H1V  A 501 (-3.8A)
 0.86A 5pbeA-6dneA:
15.5		 5pbeA-6dneA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5PBE_A_TYLA2001_1
(BROMODOMAIN ADJACENT
TO ZINC FINGER
DOMAIN PROTEIN 2B)		 6dne BROMODOMAIN-CONTAINI
NG PROTEIN 4
(Homo
sapiens) 		4 / 6 VAL A  87
TYR A  97
ASN A 140
ILE A 146
 H1V  A 501 ( 4.4A)
None
H1V  A 501 (-3.2A)
H1V  A 501 (-3.8A)
 0.50A 5pbeA-6dneA:
15.5		 5pbeA-6dneA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y1Y_A_HNQA201_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 6dne BROMODOMAIN-CONTAINI
NG PROTEIN 4
(Homo
sapiens) 		8 / 8 PRO A  82
VAL A  87
LEU A  92
LEU A  94
CYH A 136
TYR A 139
ASN A 140
ILE A 146
 H1V  A 501 (-4.6A)
H1V  A 501 ( 4.4A)
H1V  A 501 (-4.2A)
H1V  A 501 (-4.7A)
H1V  A 501 ( 4.2A)
None
H1V  A 501 (-3.2A)
H1V  A 501 (-3.8A)
 0.46A 5y1yA-6dneA:
23.4		 5y1yA-6dneA:
undetectable