SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'H1L'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OV9_B_CVIB603_0
(ACETYLCHOLINESTERASE)		 4g2r ACCD6,
CARBOXYLTRANSFERASE
BETA-SUBUNIT OF
ACYL-COA CARBOXYLASE
(Mycobacterium
tuberculosis) 		4 / 7 TYR A 141
GLN A 127
ASP A 147
HIS A 192
 H1L  A 501 (-3.6A)
None
None
None
 1.01A 5ov9B-4g2rA:
1.8		 5ov9B-4g2rA:
24.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EU9_B_REAB601_1
(RETINOIC ACID
RECEPTOR)		 4g2r ACCD6,
CARBOXYLTRANSFERASE
BETA-SUBUNIT OF
ACYL-COA CARBOXYLASE
(Mycobacterium
tuberculosis) 		5 / 10 ARG A 156
VAL A 157
LEU A 178
GLY A 133
GLY A 138
 None
H1L  A 502 (-4.9A)
None
None
H1L  A 501 (-3.4A)
 1.23A 6eu9B-4g2rA:
undetectable		 6eu9B-4g2rA:
11.51