SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'GZL'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1ERE_A_ESTA600_1 (ESTROGEN RECEPTOR)	2vk2	ABC TRANSPORTER PERIPLASMIC-BINDING PROTEIN YTFQ (Escherichia coli)	5 / 9	ALA A 252 GLU A 20 LEU A 89 ARG A 17 ILE A 62	None None None GZL A1298 (-3.9A) None	1.48A	1ereA-2vk2A: undetectable	1ereA-2vk2A: 21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1ERE_B_ESTB600_1 (ESTROGEN RECEPTOR)	2vk2	ABC TRANSPORTER PERIPLASMIC-BINDING PROTEIN YTFQ (Escherichia coli)	5 / 9	ALA A 252 GLU A 20 LEU A 89 ARG A 17 ILE A 62	None None None GZL A1298 (-3.9A) None	1.48A	1ereB-2vk2A: undetectable	1ereB-2vk2A: 21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1ERE_C_ESTC600_1 (ESTROGEN RECEPTOR)	2vk2	ABC TRANSPORTER PERIPLASMIC-BINDING PROTEIN YTFQ (Escherichia coli)	5 / 9	ALA A 252 GLU A 20 LEU A 89 ARG A 17 ILE A 62	None None None GZL A1298 (-3.9A) None	1.49A	1ereC-2vk2A: undetectable	1ereC-2vk2A: 21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1FAP_A_RAPA108_2 (FK506-BINDING PROTEIN FRAP)	2vk2	ABC TRANSPORTER PERIPLASMIC-BINDING PROTEIN YTFQ (Escherichia coli)	4 / 8	LEU A 134 ARG A 146 PHE A 150 GLY A 113	None GZL A1298 (-2.7A) None None	0.89A	1fapB-2vk2A: undetectable	1fapB-2vk2A: 14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1QKU_B_ESTB600_1 (ESTRADIOL RECEPTOR)	2vk2	ABC TRANSPORTER PERIPLASMIC-BINDING PROTEIN YTFQ (Escherichia coli)	5 / 10	ALA A 252 GLU A 20 LEU A 89 ARG A 17 ILE A 62	None None None GZL A1298 (-3.9A) None	1.44A	1qkuB-2vk2A: undetectable	1qkuB-2vk2A: 21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1QW6_A_H4BA901_1 (NITRIC-OXIDE SYNTHASE, BRAIN)	2vk2	ABC TRANSPORTER PERIPLASMIC-BINDING PROTEIN YTFQ (Escherichia coli)	3 / 3	ARG A 146 VAL A 229 TRP A 16	GZL A1298 (-2.7A) None None	1.09A	1qw6A-2vk2A: undetectable	1qw6A-2vk2A: 21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1VAG_A_H4BA901_1 (NITRIC-OXIDE SYNTHASE, BRAIN)	2vk2	ABC TRANSPORTER PERIPLASMIC-BINDING PROTEIN YTFQ (Escherichia coli)	3 / 3	ARG A 146 VAL A 229 TRP A 16	GZL A1298 (-2.7A) None None	1.07A	1vagA-2vk2A: undetectable	1vagA-2vk2A: 21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1ZVI_A_H4BA901_1 (NITRIC-OXIDE SYNTHASE, BRAIN)	2vk2	ABC TRANSPORTER PERIPLASMIC-BINDING PROTEIN YTFQ (Escherichia coli)	3 / 3	ARG A 146 VAL A 229 TRP A 16	GZL A1298 (-2.7A) None None	1.05A	1zviA-2vk2A: undetectable	1zviA-2vk2A: 21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2EJ3_C_GBNC1414_1 (BRANCHED-CHAIN AMINO ACID AMINOTRANSFERASE)	2vk2	ABC TRANSPORTER PERIPLASMIC-BINDING PROTEIN YTFQ (Escherichia coli)	5 / 8	ARG A 17 GLY A 136 THR A 137 ALA A 140 ALA A 143	GZL A1298 (-3.9A) None None None None	1.14A	2ej3C-2vk2A: undetectable	2ej3C-2vk2A: 22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2VN1_A_FK5A501_2 (70 KDA PEPTIDYLPROLYL ISOMERASE)	2vk2	ABC TRANSPORTER PERIPLASMIC-BINDING PROTEIN YTFQ (Escherichia coli)	4 / 6	LEU A 89 SER A 14 ASP A 201 GLU A 20	None GZL A1298 (-2.7A) None None	1.10A	2vn1B-2vk2A: undetectable	2vn1B-2vk2A: 20.69

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1ERE_A_ESTA600_1","ESTROGEN RECEPTOR","2vk2","ABC TRANSPORTER PERIPLASMIC-BINDING PROTEIN YTFQ","Escherichia coli",5,"ALA A 252;GLU A  20;LEU A  89;ARG A  17;ILE A  62","None;None;None;GZL A1298 (-3.9A);None","1.48A","1ereA-2vk2A:undetectable",null],["1ERE_B_ESTB600_1","ESTROGEN RECEPTOR","2vk2","ABC TRANSPORTER PERIPLASMIC-BINDING PROTEIN YTFQ","Escherichia coli",5,"ALA A 252;GLU A  20;LEU A  89;ARG A  17;ILE A  62","None;None;None;GZL A1298 (-3.9A);None","1.48A","1ereB-2vk2A:undetectable","1ereA-2vk2A:21.25"],["1ERE_C_ESTC600_1","ESTROGEN RECEPTOR","2vk2","ABC TRANSPORTER PERIPLASMIC-BINDING PROTEIN YTFQ","Escherichia coli",5,"ALA A 252;GLU A  20;LEU A  89;ARG A  17;ILE A  62","None;None;None;GZL A1298 (-3.9A);None","1.49A","1ereC-2vk2A:undetectable","1ereB-2vk2A:21.25"],["1FAP_A_RAPA108_2","FK506-BINDING PROTEIN;FRAP","2vk2","ABC TRANSPORTER PERIPLASMIC-BINDING PROTEIN YTFQ","Escherichia coli",4,"LEU A 134;ARG A 146;PHE A 150;GLY A 113","None;GZL A1298 (-2.7A);None;None","0.89A","1fapB-2vk2A:undetectable","1ereC-2vk2A:21.25"],["1QKU_B_ESTB600_1","ESTRADIOL RECEPTOR","2vk2","ABC TRANSPORTER PERIPLASMIC-BINDING PROTEIN YTFQ","Escherichia coli",5,"ALA A 252;GLU A  20;LEU A  89;ARG A  17;ILE A  62","None;None;None;GZL A1298 (-3.9A);None","1.44A","1qkuB-2vk2A:undetectable","1fapB-2vk2A:14.33"],["1QW6_A_H4BA901_1","NITRIC-OXIDE SYNTHASE, BRAIN","2vk2","ABC TRANSPORTER PERIPLASMIC-BINDING PROTEIN YTFQ","Escherichia coli",3,"ARG A 146;VAL A 229;TRP A  16","GZL A1298 (-2.7A);None;None","1.09A","1qw6A-2vk2A:undetectable","1qkuB-2vk2A:21.25"],["1VAG_A_H4BA901_1","NITRIC-OXIDE SYNTHASE, BRAIN","2vk2","ABC TRANSPORTER PERIPLASMIC-BINDING PROTEIN YTFQ","Escherichia coli",3,"ARG A 146;VAL A 229;TRP A  16","GZL A1298 (-2.7A);None;None","1.07A","1vagA-2vk2A:undetectable","1qw6A-2vk2A:21.14"],["1ZVI_A_H4BA901_1","NITRIC-OXIDE SYNTHASE, BRAIN","2vk2","ABC TRANSPORTER PERIPLASMIC-BINDING PROTEIN YTFQ","Escherichia coli",3,"ARG A 146;VAL A 229;TRP A  16","GZL A1298 (-2.7A);None;None","1.05A","1zviA-2vk2A:undetectable","1vagA-2vk2A:21.14"],["2EJ3_C_GBNC1414_1","BRANCHED-CHAIN AMINO ACID AMINOTRANSFERASE","2vk2","ABC TRANSPORTER PERIPLASMIC-BINDING PROTEIN YTFQ","Escherichia coli",5,"ARG A  17;GLY A 136;THR A 137;ALA A 140;ALA A 143","GZL A1298 (-3.9A);None;None;None;None","1.14A","2ej3C-2vk2A:undetectable","1zviA-2vk2A:21.14"],["2VN1_A_FK5A501_2","70 KDA PEPTIDYLPROLYL ISOMERASE;70 KDA PEPTIDYLPROLYL ISOMERASE","2vk2","ABC TRANSPORTER PERIPLASMIC-BINDING PROTEIN YTFQ","Escherichia coli",4,"LEU A  89;SER A  14;ASP A 201;GLU A  20","None;GZL A1298 (-2.7A);None;None","1.10A","2vn1B-2vk2A:undetectable","2ej3C-2vk2A:22.91"]]