SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'GYS'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_1
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		 2zo7 CYAN/GREEN-EMITTING
GFP-LIKE PROTEIN,
KUSABIRA-CYAN MUTANT
(KCY-R1)
(Verrillofungia
concinna) 		5 / 10 VAL A  61
VAL A  26
ASN A 134
ILE A  41
LEU A  58
 None
None
None
GYS  A  64 ( 4.8A)
None
 1.21A 1fe2A-2zo7A:
undetectable		 1fe2A-2zo7A:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J3J_B_CP6B709_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2zo7 CYAN/GREEN-EMITTING
GFP-LIKE PROTEIN,
KUSABIRA-CYAN MUTANT
(KCY-R1)
(Verrillofungia
concinna) 		5 / 9 ASP A  56
PHE A  55
ILE A  41
ILE A 205
THR A 136
 None
None
GYS  A  64 ( 4.8A)
None
None
 1.36A 1j3jB-2zo7A:
undetectable		 1j3jB-2zo7A:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDK_B_9CRB600_2
(RETINOIC ACID
RECEPTOR, BETA)		 2zo6 CYAN-EMITTING
GFP-LIKE PROTEIN,
KUSABIRA-CYAN (KCY)
(Verrillofungia
concinna) 		3 / 3 LEU A  50
PHE A  23
ARG A  91
 None
None
GYS  A  63 ( 3.0A)
 0.78A 1xdkB-2zo6A:
undetectable		 1xdkB-2zo6A:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDK_B_9CRB600_2
(RETINOIC ACID
RECEPTOR, BETA)		 2zo7 CYAN/GREEN-EMITTING
GFP-LIKE PROTEIN,
KUSABIRA-CYAN MUTANT
(KCY-R1)
(Verrillofungia
concinna) 		3 / 3 LEU A  51
PHE A  24
ARG A  92
 None
None
GYS  A  64 ( 2.9A)
 0.78A 1xdkB-2zo7A:
undetectable		 1xdkB-2zo7A:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FXD_A_DR7A102_1
(POL PROTEIN)		 2zo6 CYAN-EMITTING
GFP-LIKE PROTEIN,
KUSABIRA-CYAN (KCY)
(Verrillofungia
concinna) 		5 / 11 ILE A 195
ALA A 103
GLY A  16
PHE A  61
VAL A  60
 GYS  A  63 ( 3.7A)
None
None
None
None
 0.94A 2fxdA-2zo6A:
undetectable		 2fxdA-2zo6A:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FXD_A_DR7A102_1
(POL PROTEIN)		 2zo7 CYAN/GREEN-EMITTING
GFP-LIKE PROTEIN,
KUSABIRA-CYAN MUTANT
(KCY-R1)
(Verrillofungia
concinna) 		5 / 11 ILE A 196
ALA A 104
GLY A  17
PHE A  62
VAL A  61
 GYS  A  64 ( 3.8A)
None
None
None
None
 0.96A 2fxdA-2zo7A:
undetectable		 2fxdA-2zo7A:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD4_A_CHDA801_0
(FERROCHELATASE)		 2hpw GREEN FLUORESCENT
PROTEIN
(Clytia
gregaria) 		5 / 12 LEU A 220
LEU A  67
SER A  65
VAL A 109
VAL A  58
 None
GYS  A  68 ( 4.2A)
None
None
None
 1.28A 2qd4A-2hpwA:
undetectable		 2qd4A-2hpwA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RK8_B_PPFB3969_1
(PHOSPHOENOLPYRUVATE
CARBOXYKINASE,
CYTOSOLIC [GTP])		 2zo6 CYAN-EMITTING
GFP-LIKE PROTEIN,
KUSABIRA-CYAN (KCY)
(Verrillofungia
concinna) 		4 / 7 ARG A  66
LYS A  65
HIS A  38
ARG A  91
 GYS  A  63 ( 4.2A)
GYS  A  63 ( 3.6A)
GYS  A  63 ( 3.9A)
GYS  A  63 ( 3.0A)
 1.37A 2rk8B-2zo6A:
undetectable		 2rk8B-2zo6A:
16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CO4_A_GCSA401_1
(CHITINASE)		 2zo6 CYAN-EMITTING
GFP-LIKE PROTEIN,
KUSABIRA-CYAN (KCY)
(Verrillofungia
concinna) 		3 / 3 GLU A 143
HIS A 213
HIS A 189
 GYS  A  63 ( 4.8A)
None
None
 0.93A 3co4A-2zo6A:
undetectable		 3co4A-2zo6A:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3R_B_9PLB501_1
(CYTOCHROME P450 2A6)		 3p28 GREEN FLUORESCENT
PROTEIN
(Aequorea
victoria) 		5 / 9 PHE A  23
VAL A  64
ASN A  73
ILE A 206
PHE A 200
 None
GYS  A  18 ( 4.7A)
GYS  A  18 ( 3.6A)
None
None
 1.21A 3t3rB-3p28A:
undetectable		 3t3rB-3p28A:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3R_B_9PLB501_1
(CYTOCHROME P450 2A6)		 5j3n GREEN FLUORESCENT
PROTEIN,HSDR
(Aequorea
victoria;
Escherichia
coli) 		5 / 9 PHE A  77
VAL A 118
ASN A 127
ILE A  20
PHE A  14
 None
GYS  A  72 ( 4.8A)
GYS  A  72 ( 3.8A)
None
None
 1.15A 3t3rB-5j3nA:
undetectable		 3t3rB-5j3nA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3R_B_9PLB501_1
(CYTOCHROME P450 2A6)		 6b7t GREEN FLUORESCENT
PROTEIN,GREEN
FLUORESCENT PROTEIN
(Aequorea
victoria) 		5 / 9 PHE A 101
VAL A 142
ASN A 151
ILE A  44
PHE A  38
 None
GYS  A  96 ( 4.9A)
GYS  A  96 ( 3.6A)
None
None
 1.18A 3t3rB-6b7tA:
undetectable		 3t3rB-6b7tA:
11.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3R_C_9PLC501_1
(CYTOCHROME P450 2A6)		 3p28 GREEN FLUORESCENT
PROTEIN
(Aequorea
victoria) 		5 / 9 PHE A  23
VAL A  64
ASN A  73
ILE A 206
PHE A 200
 None
GYS  A  18 ( 4.7A)
GYS  A  18 ( 3.6A)
None
None
 1.25A 3t3rC-3p28A:
undetectable		 3t3rC-3p28A:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3R_C_9PLC501_1
(CYTOCHROME P450 2A6)		 5j3n GREEN FLUORESCENT
PROTEIN,HSDR
(Aequorea
victoria;
Escherichia
coli) 		5 / 9 PHE A  77
VAL A 118
ASN A 127
ILE A  20
PHE A  14
 None
GYS  A  72 ( 4.8A)
GYS  A  72 ( 3.8A)
None
None
 1.18A 3t3rC-5j3nA:
undetectable		 3t3rC-5j3nA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3R_C_9PLC501_1
(CYTOCHROME P450 2A6)		 6b7t GREEN FLUORESCENT
PROTEIN,GREEN
FLUORESCENT PROTEIN
(Aequorea
victoria) 		5 / 9 PHE A 101
VAL A 142
ASN A 151
ILE A  44
PHE A  38
 None
GYS  A  96 ( 4.9A)
GYS  A  96 ( 3.6A)
None
None
 1.22A 3t3rC-6b7tA:
undetectable		 3t3rC-6b7tA:
11.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3R_D_9PLD501_1
(CYTOCHROME P450 2A6)		 3p28 GREEN FLUORESCENT
PROTEIN
(Aequorea
victoria) 		5 / 10 PHE A  23
VAL A  64
ASN A  73
ILE A 206
PHE A 200
 None
GYS  A  18 ( 4.7A)
GYS  A  18 ( 3.6A)
None
None
 1.20A 3t3rD-3p28A:
undetectable		 3t3rD-3p28A:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3R_D_9PLD501_1
(CYTOCHROME P450 2A6)		 5j3n GREEN FLUORESCENT
PROTEIN,HSDR
(Aequorea
victoria;
Escherichia
coli) 		5 / 10 PHE A  77
VAL A 118
ASN A 127
ILE A  20
PHE A  14
 None
GYS  A  72 ( 4.8A)
GYS  A  72 ( 3.8A)
None
None
 1.13A 3t3rD-5j3nA:
undetectable		 3t3rD-5j3nA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3R_D_9PLD501_1
(CYTOCHROME P450 2A6)		 6b7t GREEN FLUORESCENT
PROTEIN,GREEN
FLUORESCENT PROTEIN
(Aequorea
victoria) 		5 / 10 PHE A 101
VAL A 142
ASN A 151
ILE A  44
PHE A  38
 None
GYS  A  96 ( 4.9A)
GYS  A  96 ( 3.6A)
None
None
 1.16A 3t3rD-6b7tA:
undetectable		 3t3rD-6b7tA:
11.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_A_RTZA2_1
(CYTOCHROME P450 2D6)		 2zo6 CYAN-EMITTING
GFP-LIKE PROTEIN,
KUSABIRA-CYAN (KCY)
(Verrillofungia
concinna) 		5 / 11 THR A 174
SER A 118
LEU A  56
THR A  59
PHE A  23
 None
None
None
GYS  A  63 ( 4.1A)
None
 1.42A 3tbgA-2zo6A:
undetectable		 3tbgA-2zo6A:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_A_RTZA2_1
(CYTOCHROME P450 2D6)		 2zo7 CYAN/GREEN-EMITTING
GFP-LIKE PROTEIN,
KUSABIRA-CYAN MUTANT
(KCY-R1)
(Verrillofungia
concinna) 		5 / 11 THR A 175
SER A 119
LEU A  57
THR A  60
PHE A  24
 None
None
None
GYS  A  64 ( 4.2A)
None
 1.41A 3tbgA-2zo7A:
undetectable		 3tbgA-2zo7A:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V81_C_NVPC901_1
(HIV-1 REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 2zo6 CYAN-EMITTING
GFP-LIKE PROTEIN,
KUSABIRA-CYAN (KCY)
(Verrillofungia
concinna) 		4 / 8 LEU A  57
VAL A 199
VAL A 206
LEU A  50
 None
None
GYS  A  63 ( 4.9A)
None
 0.89A 3v81C-2zo6A:
undetectable		 3v81C-2zo6A:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_I_ZPCI1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 2hpw GREEN FLUORESCENT
PROTEIN
(Clytia
gregaria) 		4 / 6 GLU A 224
ILE A  45
TYR A  49
VAL A  58
 GYS  A  68 ( 3.4A)
GYS  A  68 ( 4.3A)
None
None
 1.12A 4a97I-2hpwA:
undetectable		 4a97I-2hpwA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1Z_A_MXMA807_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 5j3n GREEN FLUORESCENT
PROTEIN,HSDR
(Aequorea
victoria;
Escherichia
coli) 		4 / 6 VAL A  61
LEU A  59
LEU A 131
PHE A 171
 None
None
None
GYS  A  72 ( 4.5A)
 0.94A 4o1zA-5j3nA:
undetectable		 4o1zA-5j3nA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1Z_A_MXMA807_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 6b7t GREEN FLUORESCENT
PROTEIN,GREEN
FLUORESCENT PROTEIN
(Aequorea
victoria) 		4 / 6 VAL A  85
LEU A  83
LEU A 155
PHE A 195
 None
None
None
GYS  A  96 ( 4.6A)
 0.90A 4o1zA-6b7tA:
undetectable		 4o1zA-6b7tA:
8.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P68_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 2zo7 CYAN/GREEN-EMITTING
GFP-LIKE PROTEIN,
KUSABIRA-CYAN MUTANT
(KCY-R1)
(Verrillofungia
concinna) 		5 / 11 ASP A  56
PHE A  55
ILE A  41
ILE A 205
THR A 136
 None
None
GYS  A  64 ( 4.8A)
None
None
 1.27A 4p68A-2zo7A:
undetectable		 4p68A-2zo7A:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PUO_C_NVPC901_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)		 2zo6 CYAN-EMITTING
GFP-LIKE PROTEIN,
KUSABIRA-CYAN (KCY)
(Verrillofungia
concinna) 		4 / 8 LEU A  57
VAL A 199
VAL A 206
LEU A  50
 None
None
GYS  A  63 ( 4.9A)
None
 0.87A 4puoC-2zo6A:
undetectable		 4puoC-2zo6A:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PWD_A_NVPA901_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)		 2zo6 CYAN-EMITTING
GFP-LIKE PROTEIN,
KUSABIRA-CYAN (KCY)
(Verrillofungia
concinna) 		4 / 8 LEU A  57
VAL A 199
VAL A 206
LEU A  50
 None
None
GYS  A  63 ( 4.9A)
None
 0.81A 4pwdA-2zo6A:
undetectable		 4pwdA-2zo6A:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0B_A_NVPA901_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)		 2zo6 CYAN-EMITTING
GFP-LIKE PROTEIN,
KUSABIRA-CYAN (KCY)
(Verrillofungia
concinna) 		4 / 8 LEU A  57
VAL A 199
VAL A 206
LEU A  50
 None
None
GYS  A  63 ( 4.9A)
None
 0.94A 4q0bA-2zo6A:
undetectable		 4q0bA-2zo6A:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LSU_B_SAMB1304_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD2)		 2hpw GREEN FLUORESCENT
PROTEIN
(Clytia
gregaria) 		3 / 3 ASN A 122
TYR A  17
CYH A  73
 GYS  A  68 ( 3.7A)
None
None
 0.72A 5lsuB-2hpwA:
undetectable		 5lsuB-2hpwA:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NU7_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 4)		 2hpw GREEN FLUORESCENT
PROTEIN
(Clytia
gregaria) 		4 / 8 ALA A 180
VAL A 124
GLN A  95
HIS A 149
 None
None
GYS  A  68 ( 3.5A)
GYS  A  68 ( 3.8A)
 0.97A 5nu7A-2hpwA:
undetectable		 5nu7A-2hpwA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CHG_C_SAMC1101_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-4 SPECIFIC)		 6b7t GREEN FLUORESCENT
PROTEIN,GREEN
FLUORESCENT PROTEIN
(Aequorea
victoria) 		5 / 12 HIS A -15
SER A -13
SER A -12
ASN A 179
HIS A -16
 None
None
GYS  A  96 ( 3.9A)
None
None
 1.39A 6chgC-6b7tA:
undetectable		 6chgC-6b7tA:
undetectable