SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'GYP'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3C_A_PNXA1435_1
(CHITINASE)		 4jre NITRITE EXTRUSION
PROTEIN 1
(Escherichia
coli) 		4 / 6 TRP A  52
GLY A 268
PHE A 270
SER A 269
 None
None
None
GYP  A 502 ( 4.8A)
 1.23A 2a3cA-4jreA:
undetectable		 2a3cA-4jreA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_D_KLND1499_1
(CYTOCHROME P450 3A4)		 4jre NITRITE EXTRUSION
PROTEIN 1
(Escherichia
coli) 		4 / 5 PHE A 370
PHE A 270
PHE A 147
ILE A 421
 None
None
NO2  A 501 (-3.3A)
GYP  A 502 (-4.6A)
 1.30A 2v0mD-4jreA:
undetectable		 2v0mD-4jreA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDM_B_AGGB1462_1
(INTEGRIN ALPHA-IIB
INTEGRIN BETA-3)		 4jre NITRITE EXTRUSION
PROTEIN 1
(Escherichia
coli) 		5 / 12 PHE A 445
TYR A 446
SER A 366
ASN A 324
ALA A 362
 GYP  A 502 (-3.7A)
GYP  A 502 ( 4.9A)
None
None
None
 1.43A 2vdmA-4jreA:
undetectable
2vdmB-4jreA:
undetectable		 2vdmA-4jreA:
24.95
2vdmB-4jreA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W1B_A_DXCA2034_0
(ACRIFLAVIN
RESISTANCE PROTEIN B)		 4jre NITRITE EXTRUSION
PROTEIN 1
(Escherichia
coli) 		3 / 3 PHE A 325
SER A 269
LEU A 264
 None
GYP  A 502 ( 4.8A)
GYP  A 502 (-4.3A)
 0.82A 2w1bA-4jreA:
undetectable		 2w1bA-4jreA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZUL_A_SAMA376_0
(PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE)		 4jre NITRITE EXTRUSION
PROTEIN 1
(Escherichia
coli) 		5 / 12 PHE A 273
GLY A 417
GLY A 268
VAL A  83
PRO A 422
 None
GYP  A 502 (-3.4A)
None
None
None
 1.03A 2zulA-4jreA:
undetectable		 2zulA-4jreA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_C_DHIC8_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 4jre NITRITE EXTRUSION
PROTEIN 1
(Escherichia
coli) 		3 / 3 SER A  82
GLY A 417
GLY A 272
 None
GYP  A 502 (-3.4A)
None
 0.45A 3bogA-4jreA:
undetectable
3bogC-4jreA:
undetectable		 3bogA-4jreA:
undetectable
3bogC-4jreA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DMF_A_SAMA388_0
(PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE)		 4jre NITRITE EXTRUSION
PROTEIN 1
(Escherichia
coli) 		5 / 12 PHE A 273
GLY A 417
GLY A 268
VAL A  83
PRO A 422
 None
GYP  A 502 (-3.4A)
None
None
None
 1.04A 3dmfA-4jreA:
undetectable		 3dmfA-4jreA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DMH_A_SAMA384_0
(PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE)		 4jre NITRITE EXTRUSION
PROTEIN 1
(Escherichia
coli) 		5 / 12 PHE A 273
GLY A 417
GLY A 268
VAL A  83
PRO A 422
 None
GYP  A 502 (-3.4A)
None
None
None
 1.05A 3dmhA-4jreA:
undetectable		 3dmhA-4jreA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_A_SASA806_1
(SEPIAPTERIN
REDUCTASE)		 4jre NITRITE EXTRUSION
PROTEIN 1
(Escherichia
coli) 		5 / 12 SER A 332
LEU A 335
TYR A 446
ALA A 362
GLY A 297
 None
None
GYP  A 502 ( 4.9A)
None
None
 1.40A 4j7xA-4jreA:
undetectable		 4j7xA-4jreA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A7P_A_9SCA601_1
(SERUM ALBUMIN)		 4jre NITRITE EXTRUSION
PROTEIN 1
(Escherichia
coli) 		4 / 5 ASN A 324
VAL A 354
LEU A 335
SER A 269
 None
None
None
GYP  A 502 ( 4.8A)
 1.29A 6a7pA-4jreA:
3.2		 6a7pA-4jreA:
20.76