SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'GXT'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_D_KLND1499_1
(CYTOCHROME P450 3A4)		 4oe7 PROBABLE
2-KETO-3-DEOXY-GALAC
TONATE ALDOLASE YAGE
(Escherichia
coli) 		4 / 5 PHE A 265
PHE A  52
PHE A 147
ILE A  71
 None
PYR  A 410 (-4.6A)
GXT  A 409 (-4.1A)
None
 1.36A 2v0mD-4oe7A:
undetectable		 2v0mD-4oe7A:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GTQ_B_ACTB207_0
(DUF1778
DOMAIN-CONTAINING
PROTEIN
N-ACETYLTRANSFERASE)		 5a8q PUTATIVE RETAINING
B-GLYCOSIDASE
(Saccharophagus
degradans) 		4 / 6 LEU A 197
THR A 196
GLY A 194
ARG A 200
 None
None
GXT  A1374 (-3.3A)
GXT  A1374 ( 3.1A)
 1.04A 6gtqB-5a8qA:
undetectable
6gtqD-5a8qA:
undetectable		 6gtqB-5a8qA:
19.94
6gtqD-5a8qA:
8.91