SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'GWM'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA3_B_STRB2001_1
(MINERALOCORTICOID
RECEPTOR)		 5gwe CYTOCHROME P450
(Corynebacterium
glutamicum) 		5 / 12 LEU A 365
ALA A 109
GLN A 110
MET A 367
THR A  97
 None
None
GWM  A 502 (-3.4A)
None
None
 1.48A 1ya3B-5gweA:
undetectable		 1ya3B-5gweA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E4E_A_4PZA501_1
(CYTOCHROME P450 2E1)		 5gwe CYTOCHROME P450
(Corynebacterium
glutamicum) 		3 / 3 ALA A 292
THR A 296
CYH A 403
 GWM  A 502 ( 3.6A)
HEM  A 501 (-3.6A)
HEM  A 501 (-2.3A)
 0.48A 3e4eA-5gweA:
31.8		 3e4eA-5gweA:
23.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E4E_B_4PZB501_1
(CYTOCHROME P450 2E1)		 5gwe CYTOCHROME P450
(Corynebacterium
glutamicum) 		3 / 3 ALA A 292
THR A 296
CYH A 403
 GWM  A 502 ( 3.6A)
HEM  A 501 (-3.6A)
HEM  A 501 (-2.3A)
 0.34A 3e4eB-5gweA:
31.9		 3e4eB-5gweA:
23.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_C_CELC682_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5gwe CYTOCHROME P450
(Corynebacterium
glutamicum) 		4 / 7 SER A 136
LEU A 263
ARG A 147
ILE A 146
 GWM  A 502 ( 2.5A)
None
HEM  A 501 ( 3.8A)
None
 1.07A 3ln1C-5gweA:
0.9		 3ln1C-5gweA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VEU_H_RITH602_1
(CYTOCHROME P450 3A5)		 5gwe CYTOCHROME P450
(Corynebacterium
glutamicum) 		5 / 12 SER A 136
GLY A 227
PHE A 291
ALA A 292
THR A 296
 GWM  A 502 ( 2.5A)
None
GWM  A 502 (-4.7A)
GWM  A 502 ( 3.6A)
HEM  A 501 (-3.6A)
 0.77A 5veuH-5gweA:
29.4		 5veuH-5gweA:
24.85