SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'GW7'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDU_D_ESTD352_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE)		 2r4b RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4
(Homo
sapiens) 		4 / 6 VAL A 786
GLY A 785
LEU A 783
GLU A 768
 None
None
GW7  A   1 (-3.9A)
None
 0.93A 1fduD-2r4bA:
undetectable		 1fduD-2r4bA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FMO_E_ADNE351_1
(CAMP-DEPENDENT
PROTEIN KINASE)		 2r4b RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4
(Homo
sapiens) 		9 / 12 LEU A 724
GLY A 725
VAL A 732
ALA A 749
VAL A 781
ASN A 848
LEU A 850
THR A 860
ASP A 861
 GW7  A   1 ( 4.2A)
None
GW7  A   1 ( 4.8A)
GW7  A   1 (-3.3A)
GW7  A   1 ( 4.7A)
None
GW7  A   1 (-4.2A)
GW7  A   1 (-3.5A)
GW7  A   1 (-4.1A)
 0.91A 1fmoE-2r4bA:
21.8		 1fmoE-2r4bA:
24.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1IEP_B_STIB202_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL)		 2r4b RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4
(Homo
sapiens) 		4 / 7 VAL A 781
MET A 799
ARG A 842
LEU A 850
 GW7  A   1 ( 4.7A)
None
None
GW7  A   1 (-4.2A)
 0.57A 1iepB-2r4bA:
28.9		 1iepB-2r4bA:
36.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1M17_A_AQ4A999_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 2r4b RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4
(Homo
sapiens) 		10 / 12 LEU A 724
ALA A 749
LYS A 751
LEU A 794
THR A 796
LEU A 798
MET A 799
GLY A 802
LEU A 850
THR A 860
 GW7  A   1 ( 4.2A)
GW7  A   1 (-3.3A)
GW7  A   1 (-3.9A)
GW7  A   1 (-4.1A)
GW7  A   1 (-4.0A)
GW7  A   1 (-4.5A)
None
GW7  A   1 (-3.6A)
GW7  A   1 (-4.2A)
GW7  A   1 (-3.5A)
 0.75A 1m17A-2r4bA:
32.2		 1m17A-2r4bA:
75.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1M17_A_AQ4A999_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 2r4b RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4
(Homo
sapiens) 		10 / 12 LEU A 724
ALA A 749
LYS A 751
LEU A 794
THR A 796
LEU A 798
MET A 799
LEU A 850
THR A 860
ASP A 861
 GW7  A   1 ( 4.2A)
GW7  A   1 (-3.3A)
GW7  A   1 (-3.9A)
GW7  A   1 (-4.1A)
GW7  A   1 (-4.0A)
GW7  A   1 (-4.5A)
None
GW7  A   1 (-4.2A)
GW7  A   1 (-3.5A)
GW7  A   1 (-4.1A)
 0.87A 1m17A-2r4bA:
32.2		 1m17A-2r4bA:
75.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1OPJ_A_STIA3_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2r4b RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4
(Homo
sapiens) 		6 / 12 LEU A 724
VAL A 732
ALA A 749
VAL A 781
THR A 796
LEU A 850
 GW7  A   1 ( 4.2A)
GW7  A   1 ( 4.8A)
GW7  A   1 (-3.3A)
GW7  A   1 ( 4.7A)
GW7  A   1 (-4.0A)
GW7  A   1 (-4.2A)
 0.72A 1opjA-2r4bA:
28.8		 1opjA-2r4bA:
36.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XBB_A_STIA1_1
(TYROSINE-PROTEIN
KINASE SYK)		 2r4b RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4
(Homo
sapiens) 		5 / 9 LEU A 724
VAL A 732
ALA A 749
GLY A 802
LEU A 850
 GW7  A   1 ( 4.2A)
GW7  A   1 ( 4.8A)
GW7  A   1 (-3.3A)
GW7  A   1 (-3.6A)
GW7  A   1 (-4.2A)
 0.51A 1xbbA-2r4bA:
30.4		 1xbbA-2r4bA:
39.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XKK_A_FMMA91_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 2r4b RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4
(Homo
sapiens) 		9 / 12 ALA A 749
MET A 772
THR A 796
GLY A 802
LEU A 805
LEU A 850
THR A 860
ASP A 861
PHE A 862
 GW7  A   1 (-3.3A)
GW7  A   1 ( 3.8A)
GW7  A   1 (-4.0A)
GW7  A   1 (-3.6A)
None
GW7  A   1 (-4.2A)
GW7  A   1 (-3.5A)
GW7  A   1 (-4.1A)
GW7  A   1 (-3.8A)
 0.47A 1xkkA-2r4bA:
39.6		 1xkkA-2r4bA:
76.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XKK_A_FMMA91_2
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 2r4b RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4
(Homo
sapiens) 		8 / 9 LEU A 724
VAL A 732
LYS A 751
LEU A 783
LEU A 794
LEU A 798
MET A 799
LEU A 864
 GW7  A   1 ( 4.2A)
GW7  A   1 ( 4.8A)
GW7  A   1 (-3.9A)
GW7  A   1 (-3.9A)
GW7  A   1 (-4.1A)
GW7  A   1 (-4.5A)
None
GW7  A   1 ( 4.7A)
 0.33A 1xkkA-2r4bA:
39.6		 1xkkA-2r4bA:
76.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_A_MIXA539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 2r4b RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4
(Homo
sapiens) 		7 / 12 LEU A 724
GLY A 725
VAL A 732
ALA A 749
ASP A 843
ASN A 848
ASP A 861
 GW7  A   1 ( 4.2A)
None
GW7  A   1 ( 4.8A)
GW7  A   1 (-3.3A)
None
None
GW7  A   1 (-4.1A)
 0.93A 2fumA-2r4bA:
18.0		 2fumA-2r4bA:
26.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2HYY_D_STID600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2r4b RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4
(Homo
sapiens) 		4 / 4 LEU A 724
LYS A 751
VAL A 781
MET A 799
 GW7  A   1 ( 4.2A)
GW7  A   1 (-3.9A)
GW7  A   1 ( 4.7A)
None
 1.03A 2hyyD-2r4bA:
29.7		 2hyyD-2r4bA:
38.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ITO_A_IREA2020_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 2r4b RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4
(Homo
sapiens) 		8 / 12 LEU A 724
ALA A 749
LYS A 751
LEU A 794
THR A 796
GLY A 802
LEU A 850
THR A 860
 GW7  A   1 ( 4.2A)
GW7  A   1 (-3.3A)
GW7  A   1 (-3.9A)
GW7  A   1 (-4.1A)
GW7  A   1 (-4.0A)
GW7  A   1 (-3.6A)
GW7  A   1 (-4.2A)
GW7  A   1 (-3.5A)
 0.66A 2itoA-2r4bA:
30.1		 2itoA-2r4bA:
78.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ITY_A_IREA2020_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 2r4b RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4
(Homo
sapiens) 		9 / 12 LEU A 724
GLY A 725
VAL A 732
ALA A 749
LEU A 794
THR A 796
GLY A 802
LEU A 850
ASP A 861
 GW7  A   1 ( 4.2A)
None
GW7  A   1 ( 4.8A)
GW7  A   1 (-3.3A)
GW7  A   1 (-4.1A)
GW7  A   1 (-4.0A)
GW7  A   1 (-3.6A)
GW7  A   1 (-4.2A)
GW7  A   1 (-4.1A)
 0.88A 2ityA-2r4bA:
35.8		 2ityA-2r4bA:
79.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ITY_A_IREA2020_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 2r4b RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4
(Homo
sapiens) 		9 / 12 LEU A 724
VAL A 732
ALA A 749
LYS A 751
LEU A 794
THR A 796
GLY A 802
LEU A 850
ASP A 861
 GW7  A   1 ( 4.2A)
GW7  A   1 ( 4.8A)
GW7  A   1 (-3.3A)
GW7  A   1 (-3.9A)
GW7  A   1 (-4.1A)
GW7  A   1 (-4.0A)
GW7  A   1 (-3.6A)
GW7  A   1 (-4.2A)
GW7  A   1 (-4.1A)
 0.91A 2ityA-2r4bA:
35.8		 2ityA-2r4bA:
79.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ITZ_A_IREA2021_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 2r4b RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4
(Homo
sapiens) 		9 / 12 LEU A 724
VAL A 732
ALA A 749
LYS A 751
THR A 796
GLY A 802
LEU A 850
THR A 860
ASP A 861
 GW7  A   1 ( 4.2A)
GW7  A   1 ( 4.8A)
GW7  A   1 (-3.3A)
GW7  A   1 (-3.9A)
GW7  A   1 (-4.0A)
GW7  A   1 (-3.6A)
GW7  A   1 (-4.2A)
GW7  A   1 (-3.5A)
GW7  A   1 (-4.1A)
 0.82A 2itzA-2r4bA:
32.5		 2itzA-2r4bA:
78.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ITZ_A_IREA2021_2
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 2r4b RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4
(Homo
sapiens) 		3 / 3 LEU A 794
LEU A 798
MET A 799
 GW7  A   1 (-4.1A)
GW7  A   1 (-4.5A)
None
 0.48A 2itzA-2r4bA:
32.5		 2itzA-2r4bA:
78.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2XP2_A_VGHA9000_1
(TYROSINE-PROTEIN
KINASE RECEPTOR)		 2r4b RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4
(Homo
sapiens) 		6 / 9 LEU A 724
VAL A 732
ALA A 749
MET A 799
GLY A 802
LEU A 850
 GW7  A   1 ( 4.2A)
GW7  A   1 ( 4.8A)
GW7  A   1 (-3.3A)
None
GW7  A   1 (-3.6A)
GW7  A   1 (-4.2A)
 0.58A 2xp2A-2r4bA:
30.4		 2xp2A-2r4bA:
32.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7J_A_B49A1294_1
(PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM)		 2r4b RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4
(Homo
sapiens) 		6 / 12 VAL A 732
ALA A 749
LEU A 798
MET A 799
GLY A 802
LEU A 850
 GW7  A   1 ( 4.8A)
GW7  A   1 (-3.3A)
GW7  A   1 (-4.5A)
None
GW7  A   1 (-3.6A)
GW7  A   1 (-4.2A)
 0.54A 2y7jA-2r4bA:
22.8		 2y7jA-2r4bA:
24.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7J_B_B49B1294_1
(PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM)		 2r4b RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4
(Homo
sapiens) 		6 / 10 VAL A 732
ALA A 749
LEU A 798
MET A 799
GLY A 802
LEU A 850
 GW7  A   1 ( 4.8A)
GW7  A   1 (-3.3A)
GW7  A   1 (-4.5A)
None
GW7  A   1 (-3.6A)
GW7  A   1 (-4.2A)
 0.59A 2y7jB-2r4bA:
23.1		 2y7jB-2r4bA:
24.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7J_C_B49C1294_1
(PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM)		 2r4b RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4
(Homo
sapiens) 		6 / 10 VAL A 732
ALA A 749
LEU A 798
MET A 799
GLY A 802
LEU A 850
 GW7  A   1 ( 4.8A)
GW7  A   1 (-3.3A)
GW7  A   1 (-4.5A)
None
GW7  A   1 (-3.6A)
GW7  A   1 (-4.2A)
 0.60A 2y7jC-2r4bA:
22.8		 2y7jC-2r4bA:
24.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7J_D_B49D1294_1
(PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM)		 2r4b RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4
(Homo
sapiens) 		6 / 10 VAL A 732
ALA A 749
LEU A 798
MET A 799
GLY A 802
LEU A 850
 GW7  A   1 ( 4.8A)
GW7  A   1 (-3.3A)
GW7  A   1 (-4.5A)
None
GW7  A   1 (-3.6A)
GW7  A   1 (-4.2A)
 0.57A 2y7jD-2r4bA:
23.1		 2y7jD-2r4bA:
24.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2YFX_A_VGHA9000_1
(TYROSINE-PROTEIN
KINASE RECEPTOR)		 2r4b RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4
(Homo
sapiens) 		5 / 8 LEU A 724
ALA A 749
MET A 799
GLY A 802
LEU A 850
 GW7  A   1 ( 4.2A)
GW7  A   1 (-3.3A)
None
GW7  A   1 (-3.6A)
GW7  A   1 (-4.2A)
 0.55A 2yfxA-2r4bA:
29.9		 2yfxA-2r4bA:
32.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2YFX_A_VGHA9000_1
(TYROSINE-PROTEIN
KINASE RECEPTOR)		 2r4b RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4
(Homo
sapiens) 		4 / 8 MET A 799
GLY A 802
LEU A 850
ASP A 861
 None
GW7  A   1 (-3.6A)
GW7  A   1 (-4.2A)
GW7  A   1 (-4.1A)
 0.63A 2yfxA-2r4bA:
29.9		 2yfxA-2r4bA:
32.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ZVA_A_1N1A513_1
(TYROSINE-PROTEIN
KINASE LYN)		 2r4b RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4
(Homo
sapiens) 		8 / 12 LEU A 724
ALA A 749
LYS A 751
VAL A 781
THR A 796
MET A 799
GLY A 802
LEU A 850
 GW7  A   1 ( 4.2A)
GW7  A   1 (-3.3A)
GW7  A   1 (-3.9A)
GW7  A   1 ( 4.7A)
GW7  A   1 (-4.0A)
None
GW7  A   1 (-3.6A)
GW7  A   1 (-4.2A)
 0.91A 2zvaA-2r4bA:
24.7		 2zvaA-2r4bA:
34.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3AOX_A_EMHA901_1
(ALK TYROSINE KINASE
RECEPTOR)		 2r4b RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4
(Homo
sapiens) 		8 / 10 LEU A 724
ALA A 749
LYS A 751
VAL A 781
LEU A 798
MET A 799
GLY A 802
LEU A 850
 GW7  A   1 ( 4.2A)
GW7  A   1 (-3.3A)
GW7  A   1 (-3.9A)
GW7  A   1 ( 4.7A)
GW7  A   1 (-4.5A)
None
GW7  A   1 (-3.6A)
GW7  A   1 (-4.2A)
 0.98A 3aoxA-2r4bA:
23.4		 3aoxA-2r4bA:
32.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3BBT_B_FMMB91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		 2r4b RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4
(Homo
sapiens) 		9 / 12 MET A 772
LEU A 783
THR A 796
GLY A 802
LEU A 850
THR A 860
ASP A 861
PHE A 862
LEU A 864
 GW7  A   1 ( 3.8A)
GW7  A   1 (-3.9A)
GW7  A   1 (-4.0A)
GW7  A   1 (-3.6A)
GW7  A   1 (-4.2A)
GW7  A   1 (-3.5A)
GW7  A   1 (-4.1A)
GW7  A   1 (-3.8A)
GW7  A   1 ( 4.7A)
 0.81A 3bbtB-2r4bA:
38.7		 3bbtB-2r4bA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3BBT_B_FMMB91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		 2r4b RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4
(Homo
sapiens) 		11 / 12 VAL A 732
ALA A 749
LEU A 783
THR A 796
LEU A 798
GLY A 802
LEU A 850
THR A 860
ASP A 861
PHE A 862
LEU A 864
 GW7  A   1 ( 4.8A)
GW7  A   1 (-3.3A)
GW7  A   1 (-3.9A)
GW7  A   1 (-4.0A)
GW7  A   1 (-4.5A)
GW7  A   1 (-3.6A)
GW7  A   1 (-4.2A)
GW7  A   1 (-3.5A)
GW7  A   1 (-4.1A)
GW7  A   1 (-3.8A)
GW7  A   1 ( 4.7A)
 0.64A 3bbtB-2r4bA:
38.7		 3bbtB-2r4bA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3BBT_D_FMMD91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		 2r4b RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4
(Homo
sapiens) 		7 / 12 MET A 772
GLY A 802
LEU A 850
THR A 860
ASP A 861
PHE A 862
LEU A 864
 GW7  A   1 ( 3.8A)
GW7  A   1 (-3.6A)
GW7  A   1 (-4.2A)
GW7  A   1 (-3.5A)
GW7  A   1 (-4.1A)
GW7  A   1 (-3.8A)
GW7  A   1 ( 4.7A)
 1.12A 3bbtD-2r4bA:
38.2		 3bbtD-2r4bA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3BBT_D_FMMD91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		 2r4b RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4
(Homo
sapiens) 		11 / 12 VAL A 732
ALA A 749
LYS A 751
LEU A 794
THR A 796
GLY A 802
LEU A 850
THR A 860
ASP A 861
PHE A 862
LEU A 864
 GW7  A   1 ( 4.8A)
GW7  A   1 (-3.3A)
GW7  A   1 (-3.9A)
GW7  A   1 (-4.1A)
GW7  A   1 (-4.0A)
GW7  A   1 (-3.6A)
GW7  A   1 (-4.2A)
GW7  A   1 (-3.5A)
GW7  A   1 (-4.1A)
GW7  A   1 (-3.8A)
GW7  A   1 ( 4.7A)
 0.68A 3bbtD-2r4bA:
38.2		 3bbtD-2r4bA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CS9_A_NILA600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2r4b RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4
(Homo
sapiens) 		6 / 12 ALA A 749
LEU A 780
THR A 796
GLY A 802
HIS A 841
LEU A 850
 GW7  A   1 (-3.3A)
None
GW7  A   1 (-4.0A)
GW7  A   1 (-3.6A)
None
GW7  A   1 (-4.2A)
 0.75A 3cs9A-2r4bA:
29.6		 3cs9A-2r4bA:
36.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3EYG_A_MI1A1_1
(TYROSINE-PROTEIN
KINASE)		 2r4b RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4
(Homo
sapiens) 		9 / 12 LEU A 724
GLY A 725
GLY A 730
VAL A 732
ALA A 749
LYS A 751
ASN A 848
LEU A 850
ASP A 861
 GW7  A   1 ( 4.2A)
None
None
GW7  A   1 ( 4.8A)
GW7  A   1 (-3.3A)
GW7  A   1 (-3.9A)
None
GW7  A   1 (-4.2A)
GW7  A   1 (-4.1A)
 0.72A 3eygA-2r4bA:
30.1		 3eygA-2r4bA:
36.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G0F_B_B49B9001_1
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR)		 2r4b RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4
(Homo
sapiens) 		6 / 10 LEU A 724
VAL A 732
ALA A 749
THR A 796
GLY A 802
LEU A 850
 GW7  A   1 ( 4.2A)
GW7  A   1 ( 4.8A)
GW7  A   1 (-3.3A)
GW7  A   1 (-4.0A)
GW7  A   1 (-3.6A)
GW7  A   1 (-4.2A)
 0.80A 3g0fB-2r4bA:
28.0		 3g0fB-2r4bA:
30.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GP0_A_NILA1_2
(MITOGEN-ACTIVATED
PROTEIN KINASE 11)		 2r4b RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4
(Homo
sapiens) 		4 / 7 LEU A 794
LEU A 798
MET A 799
ILE A 859
 GW7  A   1 (-4.1A)
GW7  A   1 (-4.5A)
None
None
 0.55A 3gp0A-2r4bA:
20.6		 3gp0A-2r4bA:
26.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GP0_A_NILA1_2
(MITOGEN-ACTIVATED
PROTEIN KINASE 11)		 2r4b RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4
(Homo
sapiens) 		4 / 7 LYS A 751
LEU A 794
LEU A 798
ILE A 859
 GW7  A   1 (-3.9A)
GW7  A   1 (-4.1A)
GW7  A   1 (-4.5A)
None
 0.80A 3gp0A-2r4bA:
20.6		 3gp0A-2r4bA:
26.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GVU_A_STIA1001_1
(TYROSINE-PROTEIN
KINASE ABL2)		 2r4b RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4
(Homo
sapiens) 		6 / 12 LEU A 724
VAL A 732
ALA A 749
VAL A 781
THR A 796
LEU A 850
 GW7  A   1 ( 4.2A)
GW7  A   1 ( 4.8A)
GW7  A   1 (-3.3A)
GW7  A   1 ( 4.7A)
GW7  A   1 (-4.0A)
GW7  A   1 (-4.2A)
 0.64A 3gvuA-2r4bA:
24.7		 3gvuA-2r4bA:
40.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3IK3_B_0LIB2_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2r4b RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4
(Homo
sapiens) 		5 / 12 ALA A 749
LEU A 780
VAL A 781
HIS A 841
LEU A 850
 GW7  A   1 (-3.3A)
None
GW7  A   1 ( 4.7A)
None
GW7  A   1 (-4.2A)
 0.71A 3ik3B-2r4bA:
29.0		 3ik3B-2r4bA:
35.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LFA_A_1N1A361_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 2r4b RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4
(Homo
sapiens) 		5 / 8 ALA A 749
LEU A 794
THR A 796
LEU A 798
MET A 799
 GW7  A   1 (-3.3A)
GW7  A   1 (-4.1A)
GW7  A   1 (-4.0A)
GW7  A   1 (-4.5A)
None
 0.45A 3lfaA-2r4bA:
19.3		 3lfaA-2r4bA:
25.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LFA_A_1N1A361_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 2r4b RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4
(Homo
sapiens) 		5 / 8 ALA A 749
LYS A 751
THR A 796
LEU A 798
MET A 799
 GW7  A   1 (-3.3A)
GW7  A   1 (-3.9A)
GW7  A   1 (-4.0A)
GW7  A   1 (-4.5A)
None
 0.61A 3lfaA-2r4bA:
19.3		 3lfaA-2r4bA:
25.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MIY_A_B49A1_1
(TYROSINE-PROTEIN
KINASE ITK/TSK)		 2r4b RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4
(Homo
sapiens) 		6 / 11 ALA A 749
LYS A 751
MET A 799
GLY A 802
LEU A 850
ASP A 861
 GW7  A   1 (-3.3A)
GW7  A   1 (-3.9A)
None
GW7  A   1 (-3.6A)
GW7  A   1 (-4.2A)
GW7  A   1 (-4.1A)
 0.78A 3miyA-2r4bA:
27.0		 3miyA-2r4bA:
33.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MIY_A_B49A1_1
(TYROSINE-PROTEIN
KINASE ITK/TSK)		 2r4b RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4
(Homo
sapiens) 		6 / 11 ALA A 749
VAL A 781
MET A 799
GLY A 802
LEU A 850
ASP A 861
 GW7  A   1 (-3.3A)
GW7  A   1 ( 4.7A)
None
GW7  A   1 (-3.6A)
GW7  A   1 (-4.2A)
GW7  A   1 (-4.1A)
 0.69A 3miyA-2r4bA:
27.0		 3miyA-2r4bA:
33.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MIY_B_B49B2_1
(TYROSINE-PROTEIN
KINASE ITK/TSK)		 2r4b RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4
(Homo
sapiens) 		5 / 9 ALA A 749
LYS A 751
MET A 799
GLY A 802
LEU A 850
 GW7  A   1 (-3.3A)
GW7  A   1 (-3.9A)
None
GW7  A   1 (-3.6A)
GW7  A   1 (-4.2A)
 0.59A 3miyB-2r4bA:
30.9		 3miyB-2r4bA:
33.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OCT_A_1N1A663_1
(TYROSINE-PROTEIN
KINASE BTK)		 2r4b RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4
(Homo
sapiens) 		8 / 12 LEU A 724
VAL A 732
ALA A 749
LYS A 751
VAL A 781
THR A 796
GLY A 802
LEU A 850
 GW7  A   1 ( 4.2A)
GW7  A   1 ( 4.8A)
GW7  A   1 (-3.3A)
GW7  A   1 (-3.9A)
GW7  A   1 ( 4.7A)
GW7  A   1 (-4.0A)
GW7  A   1 (-3.6A)
GW7  A   1 (-4.2A)
 0.79A 3octA-2r4bA:
29.0		 3octA-2r4bA:
34.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OG7_A_032A1_1
(AKAP9-BRAF FUSION
PROTEIN)		 2r4b RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4
(Homo
sapiens) 		5 / 12 VAL A 732
ALA A 749
LYS A 751
THR A 796
PHE A 862
 GW7  A   1 ( 4.8A)
GW7  A   1 (-3.3A)
GW7  A   1 (-3.9A)
GW7  A   1 (-4.0A)
GW7  A   1 (-3.8A)
 0.73A 3og7A-2r4bA:
20.8		 3og7A-2r4bA:
33.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OXZ_A_0LIA1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2r4b RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4
(Homo
sapiens) 		6 / 12 ALA A 749
LEU A 780
VAL A 781
THR A 796
GLY A 802
HIS A 841
 GW7  A   1 (-3.3A)
None
GW7  A   1 ( 4.7A)
GW7  A   1 (-4.0A)
GW7  A   1 (-3.6A)
None
 0.88A 3oxzA-2r4bA:
29.5		 3oxzA-2r4bA:
37.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3PYY_B_STIB4_1
(V-ABL ABELSON MURINE
LEUKEMIA VIRAL
ONCOGENE HOMOLOG 1
ISOFORM B VARIANT)		 2r4b RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4
(Homo
sapiens) 		6 / 12 LEU A 724
VAL A 732
ALA A 749
VAL A 781
THR A 796
LEU A 850
 GW7  A   1 ( 4.2A)
GW7  A   1 ( 4.8A)
GW7  A   1 (-3.3A)
GW7  A   1 ( 4.7A)
GW7  A   1 (-4.0A)
GW7  A   1 (-4.2A)
 0.70A 3pyyB-2r4bA:
29.4		 3pyyB-2r4bA:
39.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3SXR_A_1N1A1_1
(CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX)		 2r4b RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4
(Homo
sapiens) 		7 / 12 LEU A 724
VAL A 732
ALA A 749
VAL A 781
THR A 796
GLY A 802
LEU A 850
 GW7  A   1 ( 4.2A)
GW7  A   1 ( 4.8A)
GW7  A   1 (-3.3A)
GW7  A   1 ( 4.7A)
GW7  A   1 (-4.0A)
GW7  A   1 (-3.6A)
GW7  A   1 (-4.2A)
 0.68A 3sxrA-2r4bA:
29.3		 3sxrA-2r4bA:
33.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3SXR_B_1N1B2_1
(CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX)		 2r4b RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4
(Homo
sapiens) 		7 / 12 LEU A 724
VAL A 732
ALA A 749
VAL A 781
THR A 796
GLY A 802
LEU A 850
 GW7  A   1 ( 4.2A)
GW7  A   1 ( 4.8A)
GW7  A   1 (-3.3A)
GW7  A   1 ( 4.7A)
GW7  A   1 (-4.0A)
GW7  A   1 (-3.6A)
GW7  A   1 (-4.2A)
 0.68A 3sxrB-2r4bA:
29.0		 3sxrB-2r4bA:
33.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UE4_A_DB8A601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2r4b RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4
(Homo
sapiens) 		8 / 12 LEU A 724
ALA A 749
LYS A 751
VAL A 781
THR A 796
MET A 799
GLY A 802
LEU A 850
 GW7  A   1 ( 4.2A)
GW7  A   1 (-3.3A)
GW7  A   1 (-3.9A)
GW7  A   1 ( 4.7A)
GW7  A   1 (-4.0A)
None
GW7  A   1 (-3.6A)
GW7  A   1 (-4.2A)
 0.73A 3ue4A-2r4bA:
30.3		 3ue4A-2r4bA:
37.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UE4_B_DB8B601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2r4b RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4
(Homo
sapiens) 		7 / 12 LEU A 724
VAL A 732
ALA A 749
VAL A 781
THR A 796
GLY A 802
LEU A 850
 GW7  A   1 ( 4.2A)
GW7  A   1 ( 4.8A)
GW7  A   1 (-3.3A)
GW7  A   1 ( 4.7A)
GW7  A   1 (-4.0A)
GW7  A   1 (-3.6A)
GW7  A   1 (-4.2A)
 0.69A 3ue4B-2r4bA:
30.3		 3ue4B-2r4bA:
37.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UG2_A_IREA1_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 2r4b RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4
(Homo
sapiens) 		9 / 12 LEU A 724
VAL A 732
ALA A 749
LYS A 751
LEU A 794
LEU A 798
MET A 799
GLY A 802
LEU A 850
 GW7  A   1 ( 4.2A)
GW7  A   1 ( 4.8A)
GW7  A   1 (-3.3A)
GW7  A   1 (-3.9A)
GW7  A   1 (-4.1A)
GW7  A   1 (-4.5A)
None
GW7  A   1 (-3.6A)
GW7  A   1 (-4.2A)
 0.74A 3ug2A-2r4bA:
35.6		 3ug2A-2r4bA:
73.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 2r4b RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4
(Homo
sapiens) 		5 / 12 LEU A 724
VAL A 732
ALA A 749
GLY A 802
PHE A 862
 GW7  A   1 ( 4.2A)
GW7  A   1 ( 4.8A)
GW7  A   1 (-3.3A)
GW7  A   1 (-3.6A)
GW7  A   1 (-3.8A)
 0.50A 3wzdA-2r4bA:
29.5		 3wzdA-2r4bA:
33.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ZBF_A_VGHA3000_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ROS)		 2r4b RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4
(Homo
sapiens) 		6 / 12 LEU A 724
ALA A 749
LEU A 798
MET A 799
GLY A 802
LEU A 850
 GW7  A   1 ( 4.2A)
GW7  A   1 (-3.3A)
GW7  A   1 (-4.5A)
None
GW7  A   1 (-3.6A)
GW7  A   1 (-4.2A)
 0.68A 3zbfA-2r4bA:
29.6		 3zbfA-2r4bA:
38.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ZOS_A_0LIA1000_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 2r4b RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4
(Homo
sapiens) 		8 / 12 LEU A 724
ALA A 749
LYS A 751
THR A 796
LEU A 834
HIS A 841
ARG A 842
LEU A 850
 GW7  A   1 ( 4.2A)
GW7  A   1 (-3.3A)
GW7  A   1 (-3.9A)
GW7  A   1 (-4.0A)
None
None
None
GW7  A   1 (-4.2A)
 0.88A 3zosA-2r4bA:
28.2		 3zosA-2r4bA:
32.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4AGC_A_AXIA2000_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 2r4b RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4
(Homo
sapiens) 		6 / 12 LEU A 724
VAL A 732
ALA A 749
LYS A 751
GLY A 802
LEU A 850
 GW7  A   1 ( 4.2A)
GW7  A   1 ( 4.8A)
GW7  A   1 (-3.3A)
GW7  A   1 (-3.9A)
GW7  A   1 (-3.6A)
GW7  A   1 (-4.2A)
 0.58A 4agcA-2r4bA:
28.9		 4agcA-2r4bA:
35.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ANQ_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 2r4b RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4
(Homo
sapiens) 		6 / 9 LEU A 724
VAL A 732
ALA A 749
MET A 799
GLY A 802
LEU A 850
 GW7  A   1 ( 4.2A)
GW7  A   1 ( 4.8A)
GW7  A   1 (-3.3A)
None
GW7  A   1 (-3.6A)
GW7  A   1 (-4.2A)
 0.57A 4anqA-2r4bA:
30.1		 4anqA-2r4bA:
33.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ANS_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 2r4b RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4
(Homo
sapiens) 		6 / 9 LEU A 724
VAL A 732
ALA A 749
MET A 799
GLY A 802
LEU A 850
 GW7  A   1 ( 4.2A)
GW7  A   1 ( 4.8A)
GW7  A   1 (-3.3A)
None
GW7  A   1 (-3.6A)
GW7  A   1 (-4.2A)
 0.57A 4ansA-2r4bA:
30.0		 4ansA-2r4bA:
33.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4CKI_A_ADNA2022_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET)		 2r4b RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4
(Homo
sapiens) 		6 / 11 LEU A 724
GLY A 725
VAL A 732
ALA A 749
GLY A 802
LEU A 850
 GW7  A   1 ( 4.2A)
None
GW7  A   1 ( 4.8A)
GW7  A   1 (-3.3A)
GW7  A   1 (-3.6A)
GW7  A   1 (-4.2A)
 0.47A 4ckiA-2r4bA:
31.4		 4ckiA-2r4bA:
32.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4CKJ_A_ADNA2014_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET)		 2r4b RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4
(Homo
sapiens) 		6 / 10 LEU A 724
GLY A 725
GLY A 727
VAL A 732
ALA A 749
LEU A 850
 GW7  A   1 ( 4.2A)
None
None
GW7  A   1 ( 4.8A)
GW7  A   1 (-3.3A)
GW7  A   1 (-4.2A)
 0.40A 4ckjA-2r4bA:
28.4		 4ckjA-2r4bA:
33.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4HJO_A_AQ4A1001_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 2r4b RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4
(Homo
sapiens) 		10 / 12 LEU A 724
VAL A 732
ALA A 749
LYS A 751
THR A 796
MET A 799
GLY A 802
LEU A 850
THR A 860
ASP A 861
 GW7  A   1 ( 4.2A)
GW7  A   1 ( 4.8A)
GW7  A   1 (-3.3A)
GW7  A   1 (-3.9A)
GW7  A   1 (-4.0A)
None
GW7  A   1 (-3.6A)
GW7  A   1 (-4.2A)
GW7  A   1 (-3.5A)
GW7  A   1 (-4.1A)
 0.49A 4hjoA-2r4bA:
39.1		 4hjoA-2r4bA:
76.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4HJO_A_AQ4A1001_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 2r4b RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4
(Homo
sapiens) 		7 / 12 LYS A 751
MET A 799
GLY A 802
CYH A 803
LEU A 850
THR A 860
ASP A 861
 GW7  A   1 (-3.9A)
None
GW7  A   1 (-3.6A)
GW7  A   1 (-2.3A)
GW7  A   1 (-4.2A)
GW7  A   1 (-3.5A)
GW7  A   1 (-4.1A)
 0.84A 4hjoA-2r4bA:
39.1		 4hjoA-2r4bA:
76.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4I22_A_IREA9001_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 2r4b RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4
(Homo
sapiens) 		10 / 12 LEU A 724
GLY A 725
VAL A 732
ALA A 749
LYS A 751
LEU A 794
GLY A 802
LEU A 850
THR A 860
ASP A 861
 GW7  A   1 ( 4.2A)
None
GW7  A   1 ( 4.8A)
GW7  A   1 (-3.3A)
GW7  A   1 (-3.9A)
GW7  A   1 (-4.1A)
GW7  A   1 (-3.6A)
GW7  A   1 (-4.2A)
GW7  A   1 (-3.5A)
GW7  A   1 (-4.1A)
 0.46A 4i22A-2r4bA:
38.0		 4i22A-2r4bA:
73.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IFG_A_1E8A601_1
(CALMODULIN-DOMAIN
PROTEIN KINASE 1)		 2r4b RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4
(Homo
sapiens) 		6 / 12 GLY A 725
VAL A 732
ALA A 749
LYS A 751
LEU A 783
LEU A 794
 None
GW7  A   1 ( 4.8A)
GW7  A   1 (-3.3A)
GW7  A   1 (-3.9A)
GW7  A   1 (-3.9A)
GW7  A   1 (-4.1A)
 0.40A 4ifgA-2r4bA:
23.9		 4ifgA-2r4bA:
20.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MKC_A_4MKA1503_1
(ALK TYROSINE KINASE
RECEPTOR)		 2r4b RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4
(Homo
sapiens) 		7 / 12 LEU A 724
VAL A 732
ALA A 749
LYS A 751
LEU A 798
GLY A 802
LEU A 850
 GW7  A   1 ( 4.2A)
GW7  A   1 ( 4.8A)
GW7  A   1 (-3.3A)
GW7  A   1 (-3.9A)
GW7  A   1 (-4.5A)
GW7  A   1 (-3.6A)
GW7  A   1 (-4.2A)
 0.68A 4mkcA-2r4bA:
30.5		 4mkcA-2r4bA:
32.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXO_B_DB8B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 2r4b RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4
(Homo
sapiens) 		8 / 12 LEU A 724
VAL A 732
ALA A 749
LYS A 751
VAL A 781
THR A 796
GLY A 802
LEU A 850
 GW7  A   1 ( 4.2A)
GW7  A   1 ( 4.8A)
GW7  A   1 (-3.3A)
GW7  A   1 (-3.9A)
GW7  A   1 ( 4.7A)
GW7  A   1 (-4.0A)
GW7  A   1 (-3.6A)
GW7  A   1 (-4.2A)
 0.85A 4mxoB-2r4bA:
24.8		 4mxoB-2r4bA:
39.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXX_A_DB8A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 2r4b RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4
(Homo
sapiens) 		8 / 12 LEU A 724
ALA A 749
LYS A 751
VAL A 781
THR A 796
GLY A 802
LEU A 850
THR A 860
 GW7  A   1 ( 4.2A)
GW7  A   1 (-3.3A)
GW7  A   1 (-3.9A)
GW7  A   1 ( 4.7A)
GW7  A   1 (-4.0A)
GW7  A   1 (-3.6A)
GW7  A   1 (-4.2A)
GW7  A   1 (-3.5A)
 0.92A 4mxxA-2r4bA:
24.8		 4mxxA-2r4bA:
39.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXX_B_DB8B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 2r4b RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4
(Homo
sapiens) 		9 / 12 LEU A 724
VAL A 732
ALA A 749
LYS A 751
VAL A 781
THR A 796
MET A 799
GLY A 802
LEU A 850
 GW7  A   1 ( 4.2A)
GW7  A   1 ( 4.8A)
GW7  A   1 (-3.3A)
GW7  A   1 (-3.9A)
GW7  A   1 ( 4.7A)
GW7  A   1 (-4.0A)
None
GW7  A   1 (-3.6A)
GW7  A   1 (-4.2A)
 0.77A 4mxxB-2r4bA:
26.5		 4mxxB-2r4bA:
39.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O0S_A_ADNA500_1
(AURORA KINASE A)		 2r4b RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4
(Homo
sapiens) 		7 / 11 LEU A 724
GLY A 725
VAL A 732
ALA A 749
LYS A 751
LEU A 850
ASP A 861
 GW7  A   1 ( 4.2A)
None
GW7  A   1 ( 4.8A)
GW7  A   1 (-3.3A)
GW7  A   1 (-3.9A)
GW7  A   1 (-4.2A)
GW7  A   1 (-4.1A)
 0.95A 4o0sA-2r4bA:
24.1		 4o0sA-2r4bA:
25.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O0U_A_ADNA501_1
(AURORA KINASE A)		 2r4b RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4
(Homo
sapiens) 		4 / 6 VAL A 732
ALA A 749
LYS A 751
LEU A 850
 GW7  A   1 ( 4.8A)
GW7  A   1 (-3.3A)
GW7  A   1 (-3.9A)
GW7  A   1 (-4.2A)
 0.59A 4o0uA-2r4bA:
7.8		 4o0uA-2r4bA:
25.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O0W_A_ADNA501_1
(AURORA KINASE A)		 2r4b RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4
(Homo
sapiens) 		5 / 6 LEU A 724
GLY A 725
VAL A 732
ALA A 749
LEU A 850
 GW7  A   1 ( 4.2A)
None
GW7  A   1 ( 4.8A)
GW7  A   1 (-3.3A)
GW7  A   1 (-4.2A)
 0.64A 4o0wA-2r4bA:
23.7		 4o0wA-2r4bA:
25.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OGR_A_ADNA401_1
(CYCLIN-DEPENDENT
KINASE 9)		 2r4b RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4
(Homo
sapiens) 		5 / 8 VAL A 732
ALA A 749
ASN A 848
LEU A 850
ASP A 861
 GW7  A   1 ( 4.8A)
GW7  A   1 (-3.3A)
None
GW7  A   1 (-4.2A)
GW7  A   1 (-4.1A)
 0.43A 4ogrA-2r4bA:
23.0		 4ogrA-2r4bA:
24.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4OTW_A_DB8A1101_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-3)		 2r4b RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4
(Homo
sapiens) 		8 / 12 LEU A 724
VAL A 732
LYS A 751
VAL A 781
THR A 796
GLY A 802
LEU A 850
ASP A 861
 GW7  A   1 ( 4.2A)
GW7  A   1 ( 4.8A)
GW7  A   1 (-3.9A)
GW7  A   1 ( 4.7A)
GW7  A   1 (-4.0A)
GW7  A   1 (-3.6A)
GW7  A   1 (-4.2A)
GW7  A   1 (-4.1A)
 0.63A 4otwA-2r4bA:
36.8		 4otwA-2r4bA:
56.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QRC_A_0LIA802_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 2r4b RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4
(Homo
sapiens) 		4 / 8 LEU A 724
VAL A 732
HIS A 841
LEU A 850
 GW7  A   1 ( 4.2A)
GW7  A   1 ( 4.8A)
None
GW7  A   1 (-4.2A)
 0.43A 4qrcA-2r4bA:
29.8		 4qrcA-2r4bA:
36.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4TWP_A_AXIA601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2r4b RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4
(Homo
sapiens) 		8 / 12 LEU A 724
VAL A 732
ALA A 749
MET A 799
GLY A 802
ASN A 848
LEU A 850
ASP A 861
 GW7  A   1 ( 4.2A)
GW7  A   1 ( 4.8A)
GW7  A   1 (-3.3A)
None
GW7  A   1 (-3.6A)
None
GW7  A   1 (-4.2A)
GW7  A   1 (-4.1A)
 0.79A 4twpA-2r4bA:
25.5		 4twpA-2r4bA:
35.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4U5J_B_RXTB601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 2r4b RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4
(Homo
sapiens) 		6 / 9 LEU A 724
VAL A 732
ALA A 749
MET A 799
GLY A 802
LEU A 850
 GW7  A   1 ( 4.2A)
GW7  A   1 ( 4.8A)
GW7  A   1 (-3.3A)
None
GW7  A   1 (-3.6A)
GW7  A   1 (-4.2A)
 0.53A 4u5jB-2r4bA:
25.1		 4u5jB-2r4bA:
39.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4UXQ_A_0LIA1752_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 2r4b RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4
(Homo
sapiens) 		5 / 12 LEU A 724
ALA A 749
LEU A 834
HIS A 841
LEU A 850
 GW7  A   1 ( 4.2A)
GW7  A   1 (-3.3A)
None
None
GW7  A   1 (-4.2A)
 0.61A 4uxqA-2r4bA:
29.4		 4uxqA-2r4bA:
35.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4V01_B_0LIB1770_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 2r4b RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4
(Homo
sapiens) 		6 / 9 LEU A 724
VAL A 732
LYS A 751
ARG A 842
LEU A 850
ILE A 859
 GW7  A   1 ( 4.2A)
GW7  A   1 ( 4.8A)
GW7  A   1 (-3.9A)
None
GW7  A   1 (-4.2A)
None
 0.96A 4v01B-2r4bA:
29.5		 4v01B-2r4bA:
34.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4WA9_A_AXIA9000_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2r4b RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4
(Homo
sapiens) 		6 / 11 ALA A 749
THR A 796
MET A 799
GLY A 802
ASN A 848
LEU A 850
 GW7  A   1 (-3.3A)
GW7  A   1 (-4.0A)
None
GW7  A   1 (-3.6A)
None
GW7  A   1 (-4.2A)
 0.78A 4wa9A-2r4bA:
28.0		 4wa9A-2r4bA:
36.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4WA9_A_AXIA9000_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2r4b RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4
(Homo
sapiens) 		7 / 11 LEU A 724
ALA A 749
LYS A 751
THR A 796
MET A 799
GLY A 802
LEU A 850
 GW7  A   1 ( 4.2A)
GW7  A   1 (-3.3A)
GW7  A   1 (-3.9A)
GW7  A   1 (-4.0A)
None
GW7  A   1 (-3.6A)
GW7  A   1 (-4.2A)
 0.94A 4wa9A-2r4bA:
28.0		 4wa9A-2r4bA:
36.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WBO_C_ANWC601_0
(RHODOPSIN KINASE)		 2r4b RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4
(Homo
sapiens) 		4 / 6 LEU A 724
ALA A 749
MET A 799
LEU A 850
 GW7  A   1 ( 4.2A)
GW7  A   1 (-3.3A)
None
GW7  A   1 (-4.2A)
 0.66A 4wboC-2r4bA:
20.6		 4wboC-2r4bA:
20.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4WKQ_A_IREA1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 2r4b RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4
(Homo
sapiens) 		9 / 12 LEU A 724
ALA A 749
LYS A 751
LEU A 794
THR A 796
LEU A 798
GLY A 802
LEU A 850
THR A 860
 GW7  A   1 ( 4.2A)
GW7  A   1 (-3.3A)
GW7  A   1 (-3.9A)
GW7  A   1 (-4.1A)
GW7  A   1 (-4.0A)
GW7  A   1 (-4.5A)
GW7  A   1 (-3.6A)
GW7  A   1 (-4.2A)
GW7  A   1 (-3.5A)
 0.60A 4wkqA-2r4bA:
36.4		 4wkqA-2r4bA:
73.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XEY_A_1N1A601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2r4b RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4
(Homo
sapiens) 		7 / 12 LEU A 724
VAL A 732
ALA A 749
LYS A 751
MET A 772
VAL A 781
LEU A 850
 GW7  A   1 ( 4.2A)
GW7  A   1 ( 4.8A)
GW7  A   1 (-3.3A)
GW7  A   1 (-3.9A)
GW7  A   1 ( 3.8A)
GW7  A   1 ( 4.7A)
GW7  A   1 (-4.2A)
 0.77A 4xeyA-2r4bA:
27.4		 4xeyA-2r4bA:
32.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XEY_A_1N1A601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2r4b RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4
(Homo
sapiens) 		8 / 12 LEU A 724
VAL A 732
ALA A 749
LYS A 751
VAL A 781
THR A 796
GLY A 802
LEU A 850
 GW7  A   1 ( 4.2A)
GW7  A   1 ( 4.8A)
GW7  A   1 (-3.3A)
GW7  A   1 (-3.9A)
GW7  A   1 ( 4.7A)
GW7  A   1 (-4.0A)
GW7  A   1 (-3.6A)
GW7  A   1 (-4.2A)
 0.74A 4xeyA-2r4bA:
27.4		 4xeyA-2r4bA:
32.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XEY_B_1N1B601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2r4b RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4
(Homo
sapiens) 		7 / 12 LEU A 724
VAL A 732
ALA A 749
LYS A 751
THR A 796
GLY A 802
LEU A 850
 GW7  A   1 ( 4.2A)
GW7  A   1 ( 4.8A)
GW7  A   1 (-3.3A)
GW7  A   1 (-3.9A)
GW7  A   1 (-4.0A)
GW7  A   1 (-3.6A)
GW7  A   1 (-4.2A)
 0.65A 4xeyB-2r4bA:
30.2		 4xeyB-2r4bA:
32.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XLI_A_1N1A601_1
(NON-SPECIFIC
PROTEIN-TYROSINE
KINASE)		 2r4b RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4
(Homo
sapiens) 		8 / 12 LEU A 724
ALA A 749
LYS A 751
VAL A 781
THR A 796
MET A 799
GLY A 802
LEU A 850
 GW7  A   1 ( 4.2A)
GW7  A   1 (-3.3A)
GW7  A   1 (-3.9A)
GW7  A   1 ( 4.7A)
GW7  A   1 (-4.0A)
None
GW7  A   1 (-3.6A)
GW7  A   1 (-4.2A)
 0.78A 4xliA-2r4bA:
25.4		 4xliA-2r4bA:
37.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XOY_A_DX4A401_0
(MITOGEN-ACTIVATED
PROTEIN KINASE 1)		 2r4b RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4
(Homo
sapiens) 		4 / 6 ALA A 749
LEU A 798
MET A 799
LEU A 850
 GW7  A   1 (-3.3A)
GW7  A   1 (-4.5A)
None
GW7  A   1 (-4.2A)
 0.46A 4xoyA-2r4bA:
21.1		 4xoyA-2r4bA:
24.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XP3_A_DX4A401_0
(MITOGEN-ACTIVATED
PROTEIN KINASE 1)		 2r4b RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4
(Homo
sapiens) 		4 / 6 ALA A 749
LEU A 798
MET A 799
LEU A 850
 GW7  A   1 (-3.3A)
GW7  A   1 (-4.5A)
None
GW7  A   1 (-4.2A)
 0.50A 4xp3A-2r4bA:
21.3		 4xp3A-2r4bA:
24.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AAA_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 2r4b RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4
(Homo
sapiens) 		6 / 9 LEU A 724
VAL A 732
ALA A 749
MET A 799
GLY A 802
LEU A 850
 GW7  A   1 ( 4.2A)
GW7  A   1 ( 4.8A)
GW7  A   1 (-3.3A)
None
GW7  A   1 (-3.6A)
GW7  A   1 (-4.2A)
 0.49A 5aaaA-2r4bA:
30.5		 5aaaA-2r4bA:
32.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AAB_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 2r4b RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4
(Homo
sapiens) 		7 / 10 LEU A 724
VAL A 732
ALA A 749
LYS A 751
MET A 799
GLY A 802
LEU A 850
 GW7  A   1 ( 4.2A)
GW7  A   1 ( 4.8A)
GW7  A   1 (-3.3A)
GW7  A   1 (-3.9A)
None
GW7  A   1 (-3.6A)
GW7  A   1 (-4.2A)
 0.56A 5aabA-2r4bA:
30.4		 5aabA-2r4bA:
32.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AAC_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 2r4b RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4
(Homo
sapiens) 		7 / 10 LEU A 724
VAL A 732
ALA A 749
LYS A 751
MET A 799
GLY A 802
LEU A 850
 GW7  A   1 ( 4.2A)
GW7  A   1 ( 4.8A)
GW7  A   1 (-3.3A)
GW7  A   1 (-3.9A)
None
GW7  A   1 (-3.6A)
GW7  A   1 (-4.2A)
 0.66A 5aacA-2r4bA:
22.8		 5aacA-2r4bA:
32.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AJQ_A_DB8A800_1
(SERINE/THREONINE-PRO
TEIN KINASE 10)		 2r4b RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4
(Homo
sapiens) 		6 / 12 LEU A 724
ALA A 749
GLY A 802
GLU A 810
LEU A 850
ASP A 861
 GW7  A   1 ( 4.2A)
GW7  A   1 (-3.3A)
GW7  A   1 (-3.6A)
None
GW7  A   1 (-4.2A)
GW7  A   1 (-4.1A)
 0.89A 5ajqA-2r4bA:
24.1		 5ajqA-2r4bA:
26.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AJQ_A_DB8A800_1
(SERINE/THREONINE-PRO
TEIN KINASE 10)		 2r4b RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4
(Homo
sapiens) 		6 / 12 LEU A 724
ALA A 749
LYS A 751
GLY A 802
GLU A 810
LEU A 850
 GW7  A   1 ( 4.2A)
GW7  A   1 (-3.3A)
GW7  A   1 (-3.9A)
GW7  A   1 (-3.6A)
None
GW7  A   1 (-4.2A)
 0.84A 5ajqA-2r4bA:
24.1		 5ajqA-2r4bA:
26.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5H2U_A_1N1A501_1
(PROTEIN-TYROSINE
KINASE 6)		 2r4b RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4
(Homo
sapiens) 		7 / 12 LEU A 724
VAL A 732
ALA A 749
THR A 796
LEU A 798
GLY A 802
LEU A 850
 GW7  A   1 ( 4.2A)
GW7  A   1 ( 4.8A)
GW7  A   1 (-3.3A)
GW7  A   1 (-4.0A)
GW7  A   1 (-4.5A)
GW7  A   1 (-3.6A)
GW7  A   1 (-4.2A)
 0.52A 5h2uA-2r4bA:
32.4		 5h2uA-2r4bA:
31.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5H2U_B_1N1B501_1
(PROTEIN-TYROSINE
KINASE 6)		 2r4b RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4
(Homo
sapiens) 		8 / 12 LEU A 724
VAL A 732
ALA A 749
THR A 796
LEU A 798
GLY A 802
LEU A 850
ASP A 861
 GW7  A   1 ( 4.2A)
GW7  A   1 ( 4.8A)
GW7  A   1 (-3.3A)
GW7  A   1 (-4.0A)
GW7  A   1 (-4.5A)
GW7  A   1 (-3.6A)
GW7  A   1 (-4.2A)
GW7  A   1 (-4.1A)
 0.68A 5h2uB-2r4bA:
32.4		 5h2uB-2r4bA:
31.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5H2U_C_1N1C501_1
(PROTEIN-TYROSINE
KINASE 6)		 2r4b RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4
(Homo
sapiens) 		6 / 12 LEU A 724
ALA A 749
THR A 796
GLY A 802
LEU A 850
ASP A 861
 GW7  A   1 ( 4.2A)
GW7  A   1 (-3.3A)
GW7  A   1 (-4.0A)
GW7  A   1 (-3.6A)
GW7  A   1 (-4.2A)
GW7  A   1 (-4.1A)
 0.69A 5h2uC-2r4bA:
28.0		 5h2uC-2r4bA:
31.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5H2U_D_1N1D504_1
(PROTEIN-TYROSINE
KINASE 6)		 2r4b RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4
(Homo
sapiens) 		8 / 12 LEU A 724
VAL A 732
ALA A 749
THR A 796
LEU A 798
GLY A 802
LEU A 850
ASP A 861
 GW7  A   1 ( 4.2A)
GW7  A   1 ( 4.8A)
GW7  A   1 (-3.3A)
GW7  A   1 (-4.0A)
GW7  A   1 (-4.5A)
GW7  A   1 (-3.6A)
GW7  A   1 (-4.2A)
GW7  A   1 (-4.1A)
 0.64A 5h2uD-2r4bA:
32.4		 5h2uD-2r4bA:
31.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HIE_C_P06C801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 2r4b RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4
(Homo
sapiens) 		6 / 12 GLY A 725
VAL A 732
ALA A 749
LYS A 751
THR A 796
ASP A 861
 None
GW7  A   1 ( 4.8A)
GW7  A   1 (-3.3A)
GW7  A   1 (-3.9A)
GW7  A   1 (-4.0A)
GW7  A   1 (-4.1A)
 1.11A 5hieC-2r4bA:
26.7		 5hieC-2r4bA:
30.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5I9Y_A_1N1A1001_1
(EPHRIN TYPE-A
RECEPTOR 2)		 2r4b RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4
(Homo
sapiens) 		6 / 12 ALA A 749
LYS A 751
THR A 796
GLY A 802
GLU A 810
LEU A 850
 GW7  A   1 (-3.3A)
GW7  A   1 (-3.9A)
GW7  A   1 (-4.0A)
GW7  A   1 (-3.6A)
None
GW7  A   1 (-4.2A)
 0.64A 5i9yA-2r4bA:
27.1		 5i9yA-2r4bA:
38.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IZJ_F_AZ1F2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAR-DAR-DAR)		 2r4b RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4
(Homo
sapiens) 		5 / 7 GLY A 725
GLY A 727
GLY A 730
VAL A 732
LEU A 753
 None
None
None
GW7  A   1 ( 4.8A)
None
 0.85A 5izjB-2r4bA:
11.1		 5izjB-2r4bA:
24.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LW1_E_ADNE401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 8)		 2r4b RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4
(Homo
sapiens) 		5 / 10 GLY A 725
VAL A 732
ALA A 749
LEU A 798
MET A 799
 None
GW7  A   1 ( 4.8A)
GW7  A   1 (-3.3A)
GW7  A   1 (-4.5A)
None
 0.71A 5lw1E-2r4bA:
16.3		 5lw1E-2r4bA:
13.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LW1_H_ADNH401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 8)		 2r4b RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4
(Homo
sapiens) 		5 / 9 GLY A 725
VAL A 732
ALA A 749
LEU A 798
MET A 799
 None
GW7  A   1 ( 4.8A)
GW7  A   1 (-3.3A)
GW7  A   1 (-4.5A)
None
 0.61A 5lw1H-2r4bA:
19.9		 5lw1H-2r4bA:
13.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MO4_A_NILA601_2
(TYROSINE-PROTEIN
KINASE ABL1)		 2r4b RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4
(Homo
sapiens) 		5 / 12 ALA A 749
LEU A 780
VAL A 781
HIS A 841
LEU A 850
 GW7  A   1 (-3.3A)
None
GW7  A   1 ( 4.7A)
None
GW7  A   1 (-4.2A)
 0.78A 5mo4A-2r4bA:
25.3		 5mo4A-2r4bA:
27.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N3H_A_NCAA401_0
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA)		 2r4b RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4
(Homo
sapiens) 		6 / 10 LEU A 724
VAL A 732
ALA A 749
VAL A 781
LEU A 850
THR A 860
 GW7  A   1 ( 4.2A)
GW7  A   1 ( 4.8A)
GW7  A   1 (-3.3A)
GW7  A   1 ( 4.7A)
GW7  A   1 (-4.2A)
GW7  A   1 (-3.5A)
 0.49A 5n3hA-2r4bA:
10.4		 5n3hA-2r4bA:
24.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5P9I_A_1E8A701_1
(TYROSINE-PROTEIN
KINASE BTK)		 2r4b RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4
(Homo
sapiens) 		6 / 12 VAL A 732
ALA A 749
THR A 796
GLY A 802
LEU A 850
PHE A 862
 GW7  A   1 ( 4.8A)
GW7  A   1 (-3.3A)
GW7  A   1 (-4.0A)
GW7  A   1 (-3.6A)
GW7  A   1 (-4.2A)
GW7  A   1 (-3.8A)
 0.94A 5p9iA-2r4bA:
30.7		 5p9iA-2r4bA:
35.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCY_A_DB8A401_2
(MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE)		 2r4b RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4
(Homo
sapiens) 		4 / 4 VAL A 781
LEU A 798
ASN A 848
ASP A 861
 GW7  A   1 ( 4.7A)
GW7  A   1 (-4.5A)
None
GW7  A   1 (-4.1A)
 1.10A 5vcyA-2r4bA:
22.2		 5vcyA-2r4bA:
26.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W5V_A_ANWA701_0
(SERINE/THREONINE-PRO
TEIN KINASE TBK1)		 2r4b RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4
(Homo
sapiens) 		5 / 9 LEU A 724
ALA A 749
VAL A 781
GLY A 802
THR A 860
 GW7  A   1 ( 4.2A)
GW7  A   1 (-3.3A)
GW7  A   1 ( 4.7A)
GW7  A   1 (-3.6A)
GW7  A   1 (-3.5A)
 0.82A 5w5vA-2r4bA:
13.5		 5w5vA-2r4bA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7Z_A_IREA401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 2r4b RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4
(Homo
sapiens) 		6 / 12 LEU A 724
VAL A 732
ALA A 749
LEU A 798
GLY A 802
LEU A 850
 GW7  A   1 ( 4.2A)
GW7  A   1 ( 4.8A)
GW7  A   1 (-3.3A)
GW7  A   1 (-4.5A)
GW7  A   1 (-3.6A)
GW7  A   1 (-4.2A)
 0.41A 5y7zA-2r4bA:
21.4		 5y7zA-2r4bA:
12.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7Z_A_IREA401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 2r4b RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4
(Homo
sapiens) 		6 / 12 LEU A 724
VAL A 732
ALA A 749
LEU A 798
GLY A 802
LEU A 850
 GW7  A   1 ( 4.2A)
GW7  A   1 ( 4.8A)
GW7  A   1 (-3.3A)
GW7  A   1 (-4.5A)
GW7  A   1 (-3.6A)
GW7  A   1 (-4.2A)
 0.41A 5y7zA-2r4bA:
21.4		 5y7zA-2r4bA:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7Z_B_IREB401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 2r4b RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4
(Homo
sapiens) 		7 / 12 LEU A 724
ALA A 749
LEU A 794
LEU A 798
GLY A 802
LEU A 850
ASP A 861
 GW7  A   1 ( 4.2A)
GW7  A   1 (-3.3A)
GW7  A   1 (-4.1A)
GW7  A   1 (-4.5A)
GW7  A   1 (-3.6A)
GW7  A   1 (-4.2A)
GW7  A   1 (-4.1A)
 0.64A 5y7zB-2r4bA:
21.5		 5y7zB-2r4bA:
12.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y80_A_IREA401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 2r4b RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4
(Homo
sapiens) 		8 / 12 LEU A 724
VAL A 732
ALA A 749
THR A 796
LEU A 798
GLY A 802
LEU A 850
ASP A 861
 GW7  A   1 ( 4.2A)
GW7  A   1 ( 4.8A)
GW7  A   1 (-3.3A)
GW7  A   1 (-4.0A)
GW7  A   1 (-4.5A)
GW7  A   1 (-3.6A)
GW7  A   1 (-4.2A)
GW7  A   1 (-4.1A)
 0.63A 5y80A-2r4bA:
20.7		 5y80A-2r4bA:
12.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YU9_A_1E8A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 2r4b RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4
(Homo
sapiens) 		7 / 12 GLY A 725
VAL A 732
LYS A 751
LEU A 794
CYH A 803
THR A 860
ASP A 861
 None
GW7  A   1 ( 4.8A)
GW7  A   1 (-3.9A)
GW7  A   1 (-4.1A)
GW7  A   1 (-2.3A)
GW7  A   1 (-3.5A)
GW7  A   1 (-4.1A)
 0.96A 5yu9A-2r4bA:
32.4		 5yu9A-2r4bA:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YU9_A_1E8A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 2r4b RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4
(Homo
sapiens) 		9 / 12 LEU A 724
GLY A 725
VAL A 732
ALA A 749
LYS A 751
LEU A 794
LEU A 850
THR A 860
ASP A 861
 GW7  A   1 ( 4.2A)
None
GW7  A   1 ( 4.8A)
GW7  A   1 (-3.3A)
GW7  A   1 (-3.9A)
GW7  A   1 (-4.1A)
GW7  A   1 (-4.2A)
GW7  A   1 (-3.5A)
GW7  A   1 (-4.1A)
 0.72A 5yu9A-2r4bA:
32.4		 5yu9A-2r4bA:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YU9_B_1E8B1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 2r4b RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4
(Homo
sapiens) 		8 / 12 GLY A 725
VAL A 732
ALA A 749
LYS A 751
LEU A 794
LEU A 850
THR A 860
ASP A 861
 None
GW7  A   1 ( 4.8A)
GW7  A   1 (-3.3A)
GW7  A   1 (-3.9A)
GW7  A   1 (-4.1A)
GW7  A   1 (-4.2A)
GW7  A   1 (-3.5A)
GW7  A   1 (-4.1A)
 0.72A 5yu9B-2r4bA:
37.5		 5yu9B-2r4bA:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YU9_B_1E8B1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 2r4b RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4
(Homo
sapiens) 		6 / 12 LYS A 751
MET A 772
LEU A 794
LEU A 850
THR A 860
ASP A 861
 GW7  A   1 (-3.9A)
GW7  A   1 ( 3.8A)
GW7  A   1 (-4.1A)
GW7  A   1 (-4.2A)
GW7  A   1 (-3.5A)
GW7  A   1 (-4.1A)
 0.85A 5yu9B-2r4bA:
37.5		 5yu9B-2r4bA:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YU9_C_1E8C1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 2r4b RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4
(Homo
sapiens) 		6 / 12 ALA A 749
LYS A 751
LEU A 794
ARG A 847
THR A 860
ASP A 861
 GW7  A   1 (-3.3A)
GW7  A   1 (-3.9A)
GW7  A   1 (-4.1A)
None
GW7  A   1 (-3.5A)
GW7  A   1 (-4.1A)
 1.35A 5yu9C-2r4bA:
37.2		 5yu9C-2r4bA:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YU9_C_1E8C1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 2r4b RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4
(Homo
sapiens) 		5 / 12 LYS A 751
MET A 772
LEU A 794
THR A 860
ASP A 861
 GW7  A   1 (-3.9A)
GW7  A   1 ( 3.8A)
GW7  A   1 (-4.1A)
GW7  A   1 (-3.5A)
GW7  A   1 (-4.1A)
 0.75A 5yu9C-2r4bA:
37.2		 5yu9C-2r4bA:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YU9_C_1E8C1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 2r4b RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4
(Homo
sapiens) 		6 / 12 VAL A 732
ALA A 749
LYS A 751
LEU A 794
GLY A 802
THR A 860
 GW7  A   1 ( 4.8A)
GW7  A   1 (-3.3A)
GW7  A   1 (-3.9A)
GW7  A   1 (-4.1A)
GW7  A   1 (-3.6A)
GW7  A   1 (-3.5A)
 0.75A 5yu9C-2r4bA:
37.2		 5yu9C-2r4bA:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YU9_C_1E8C1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 2r4b RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4
(Homo
sapiens) 		6 / 12 VAL A 732
ALA A 749
LYS A 751
LEU A 794
THR A 860
ASP A 861
 GW7  A   1 ( 4.8A)
GW7  A   1 (-3.3A)
GW7  A   1 (-3.9A)
GW7  A   1 (-4.1A)
GW7  A   1 (-3.5A)
GW7  A   1 (-4.1A)
 0.65A 5yu9C-2r4bA:
37.2		 5yu9C-2r4bA:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YU9_D_1E8D1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 2r4b RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4
(Homo
sapiens) 		6 / 12 LYS A 751
MET A 772
LEU A 850
THR A 860
ASP A 861
LEU A 864
 GW7  A   1 (-3.9A)
GW7  A   1 ( 3.8A)
GW7  A   1 (-4.2A)
GW7  A   1 (-3.5A)
GW7  A   1 (-4.1A)
GW7  A   1 ( 4.7A)
 0.85A 5yu9D-2r4bA:
37.5		 5yu9D-2r4bA:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YU9_D_1E8D1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 2r4b RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4
(Homo
sapiens) 		6 / 12 VAL A 732
ALA A 749
GLY A 802
LEU A 850
THR A 860
LEU A 864
 GW7  A   1 ( 4.8A)
GW7  A   1 (-3.3A)
GW7  A   1 (-3.6A)
GW7  A   1 (-4.2A)
GW7  A   1 (-3.5A)
GW7  A   1 ( 4.7A)
 0.73A 5yu9D-2r4bA:
37.5		 5yu9D-2r4bA:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YU9_D_1E8D1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 2r4b RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4
(Homo
sapiens) 		7 / 12 VAL A 732
ALA A 749
LYS A 751
LEU A 850
THR A 860
ASP A 861
LEU A 864
 GW7  A   1 ( 4.8A)
GW7  A   1 (-3.3A)
GW7  A   1 (-3.9A)
GW7  A   1 (-4.2A)
GW7  A   1 (-3.5A)
GW7  A   1 (-4.1A)
GW7  A   1 ( 4.7A)
 0.74A 5yu9D-2r4bA:
37.5		 5yu9D-2r4bA:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSD_A_1N1A901_0
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 2r4b RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4
(Homo
sapiens) 		7 / 12 VAL A 732
ALA A 749
LYS A 751
THR A 796
MET A 799
GLY A 802
LEU A 850
 GW7  A   1 ( 4.8A)
GW7  A   1 (-3.3A)
GW7  A   1 (-3.9A)
GW7  A   1 (-4.0A)
None
GW7  A   1 (-3.6A)
GW7  A   1 (-4.2A)
 0.69A 6bsdA-2r4bA:
28.2		 6bsdA-2r4bA:
12.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6FNM_A_1N1A1001_1
(-)		 2r4b RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4
(Homo
sapiens) 		7 / 12 VAL A 732
ALA A 749
LYS A 751
THR A 796
MET A 799
GLY A 802
LEU A 850
 GW7  A   1 ( 4.8A)
GW7  A   1 (-3.3A)
GW7  A   1 (-3.9A)
GW7  A   1 (-4.0A)
None
GW7  A   1 (-3.6A)
GW7  A   1 (-4.2A)
 0.75A 6fnmA-2r4bA:
28.3		 6fnmA-2r4bA:
39.23