SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'GVR'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1VHW_A_ADNA252_1 (PURINE NUCLEOSIDE PHOSPHORYLASE)	4isa	UDP-3-O-[3-HYDROXYMY RISTOYL] N-ACETYLGLUCOSAMINE DEACETYLASE (Escherichia coli)	5 / 11	GLY A 193 VAL A 217 GLU A 234 ILE A 198 HIS A 79	GVR A 402 (-3.6A) None None FMT A 405 ( 3.7A) ZN A 401 ( 3.3A)	1.08A	1vhwA-4isaA: undetectable 1vhwD-4isaA: undetectable	1vhwA-4isaA: 21.47 1vhwD-4isaA: 21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1VHW_C_ADNC252_1 (PURINE NUCLEOSIDE PHOSPHORYLASE)	4isa	UDP-3-O-[3-HYDROXYMY RISTOYL] N-ACETYLGLUCOSAMINE DEACETYLASE (Escherichia coli)	5 / 11	GLY A 193 VAL A 217 GLU A 234 ILE A 198 HIS A 79	GVR A 402 (-3.6A) None None FMT A 405 ( 3.7A) ZN A 401 ( 3.3A)	1.07A	1vhwC-4isaA: undetectable 1vhwE-4isaA: undetectable	1vhwC-4isaA: 21.47 1vhwE-4isaA: 21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1VHW_D_ADND252_1 (PURINE NUCLEOSIDE PHOSPHORYLASE)	4isa	UDP-3-O-[3-HYDROXYMY RISTOYL] N-ACETYLGLUCOSAMINE DEACETYLASE (Escherichia coli)	5 / 11	HIS A 79 GLY A 193 VAL A 217 GLU A 234 ILE A 198	ZN A 401 ( 3.3A) GVR A 402 (-3.6A) None None FMT A 405 ( 3.7A)	1.06A	1vhwA-4isaA: undetectable 1vhwD-4isaA: undetectable	1vhwA-4isaA: 21.47 1vhwD-4isaA: 21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1VHW_E_ADNE252_1 (PURINE NUCLEOSIDE PHOSPHORYLASE)	4isa	UDP-3-O-[3-HYDROXYMY RISTOYL] N-ACETYLGLUCOSAMINE DEACETYLASE (Escherichia coli)	5 / 11	HIS A 79 GLY A 193 VAL A 217 GLU A 234 ILE A 198	ZN A 401 ( 3.3A) GVR A 402 (-3.6A) None None FMT A 405 ( 3.7A)	1.08A	1vhwC-4isaA: undetectable 1vhwE-4isaA: undetectable	1vhwC-4isaA: 21.47 1vhwE-4isaA: 21.47

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1VHW_A_ADNA252_1","PURINE NUCLEOSIDE PHOSPHORYLASE;PURINE NUCLEOSIDE PHOSPHORYLASE","4isa","UDP-3-O-[3-HYDROXYMYRISTOYL] N-ACETYLGLUCOSAMINE DEACETYLASE","Escherichia coli",5,"GLY A 193;VAL A 217;GLU A 234;ILE A 198;HIS A  79","GVR A 402 (-3.6A);None;None;FMT A 405 ( 3.7A); ZN A 401 ( 3.3A)","1.08A","1vhwA-4isaA:undetectable;1vhwD-4isaA:undetectable",null],["1VHW_C_ADNC252_1","PURINE NUCLEOSIDE PHOSPHORYLASE;PURINE NUCLEOSIDE PHOSPHORYLASE","4isa","UDP-3-O-[3-HYDROXYMYRISTOYL] N-ACETYLGLUCOSAMINE DEACETYLASE","Escherichia coli",5,"GLY A 193;VAL A 217;GLU A 234;ILE A 198;HIS A  79","GVR A 402 (-3.6A);None;None;FMT A 405 ( 3.7A); ZN A 401 ( 3.3A)","1.07A","1vhwC-4isaA:undetectable;1vhwE-4isaA:undetectable","1vhwA-4isaA:21.47;1vhwD-4isaA:21.47"],["1VHW_D_ADND252_1","PURINE NUCLEOSIDE PHOSPHORYLASE;PURINE NUCLEOSIDE PHOSPHORYLASE","4isa","UDP-3-O-[3-HYDROXYMYRISTOYL] N-ACETYLGLUCOSAMINE DEACETYLASE","Escherichia coli",5,"HIS A  79;GLY A 193;VAL A 217;GLU A 234;ILE A 198"," ZN A 401 ( 3.3A);GVR A 402 (-3.6A);None;None;FMT A 405 ( 3.7A)","1.06A","1vhwA-4isaA:undetectable;1vhwD-4isaA:undetectable","1vhwC-4isaA:21.47;1vhwE-4isaA:21.47"],["1VHW_E_ADNE252_1","PURINE NUCLEOSIDE PHOSPHORYLASE;PURINE NUCLEOSIDE PHOSPHORYLASE","4isa","UDP-3-O-[3-HYDROXYMYRISTOYL] N-ACETYLGLUCOSAMINE DEACETYLASE","Escherichia coli",5,"HIS A  79;GLY A 193;VAL A 217;GLU A 234;ILE A 198"," ZN A 401 ( 3.3A);GVR A 402 (-3.6A);None;None;FMT A 405 ( 3.7A)","1.08A","1vhwC-4isaA:undetectable;1vhwE-4isaA:undetectable","1vhwA-4isaA:21.47;1vhwD-4isaA:21.47"]]