SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'GUI'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1FMO_E_ADNE351_1
(CAMP-DEPENDENT
PROTEIN KINASE)		 5jzn SERINE/THREONINE-PRO
TEIN KINASE DCLK1
(Homo
sapiens) 		7 / 12 GLY A 397
VAL A 404
ALA A 417
VAL A 449
VAL A 468
LEU A 518
ASP A 533
 GUI  A 701 ( 3.8A)
GUI  A 701 (-4.4A)
GUI  A 701 ( 3.9A)
None
GUI  A 701 (-4.0A)
GUI  A 701 (-4.4A)
GUI  A 701 ( 4.8A)
 0.65A 1fmoE-5jznA:
25.3		 1fmoE-5jznA:
35.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1FMO_E_ADNE351_1
(CAMP-DEPENDENT
PROTEIN KINASE)		 5jzn SERINE/THREONINE-PRO
TEIN KINASE DCLK1
(Homo
sapiens) 		7 / 12 VAL A 404
ALA A 417
VAL A 449
VAL A 468
ASN A 516
LEU A 518
ASP A 533
 GUI  A 701 (-4.4A)
GUI  A 701 ( 3.9A)
None
GUI  A 701 (-4.0A)
GUI  A 701 (-4.4A)
GUI  A 701 (-4.4A)
GUI  A 701 ( 4.8A)
 0.62A 1fmoE-5jznA:
25.3		 1fmoE-5jznA:
35.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JLF_A_NVPA999_1
(HIV-1 RT A-CHAIN
HIV-1 RT B-CHAIN)		 4e93 TYROSINE-PROTEIN
KINASE FES/FPS
(Homo
sapiens) 		4 / 8 LEU A 648
VAL A 691
CYH A 689
GLY A 642
 None
None
None
GUI  A 901 (-3.5A)
 1.01A 1jlfA-4e93A:
undetectable
1jlfB-4e93A:
undetectable		 1jlfA-4e93A:
22.60
1jlfB-4e93A:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M17_A_AQ4A999_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 5jzn SERINE/THREONINE-PRO
TEIN KINASE DCLK1
(Homo
sapiens) 		7 / 12 ALA A 417
LYS A 419
GLU A 436
LEU A 463
LEU A 467
GLY A 471
LEU A 518
 GUI  A 701 ( 3.9A)
GUI  A 701 (-3.1A)
None
None
GUI  A 701 ( 4.7A)
GUI  A 701 (-3.6A)
GUI  A 701 (-4.4A)
 0.76A 1m17A-5jznA:
24.8		 1m17A-5jznA:
26.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T46_A_STIA3_1
(HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG)		 5jzn SERINE/THREONINE-PRO
TEIN KINASE DCLK1
(Homo
sapiens) 		9 / 12 VAL A 404
ALA A 417
LYS A 419
GLU A 436
LEU A 440
VAL A 449
GLY A 471
LEU A 518
ASP A 533
 GUI  A 701 (-4.4A)
GUI  A 701 ( 3.9A)
GUI  A 701 (-3.1A)
None
None
None
GUI  A 701 (-3.6A)
GUI  A 701 (-4.4A)
GUI  A 701 ( 4.8A)
 1.06A 1t46A-5jznA:
21.9		 1t46A-5jznA:
28.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWH_A_BAXA1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 5jzn SERINE/THREONINE-PRO
TEIN KINASE DCLK1
(Homo
sapiens) 		6 / 12 ALA A 417
GLU A 436
LEU A 440
LEU A 502
HIS A 509
GLY A 532
 GUI  A 701 ( 3.9A)
None
None
None
None
GUI  A 701 ( 4.7A)
 0.82A 1uwhA-5jznA:
23.7		 1uwhA-5jznA:
27.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWH_B_BAXB1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 5jzn SERINE/THREONINE-PRO
TEIN KINASE DCLK1
(Homo
sapiens) 		6 / 12 ALA A 417
GLU A 436
LEU A 440
LEU A 502
HIS A 509
GLY A 532
 GUI  A 701 ( 3.9A)
None
None
None
None
GUI  A 701 ( 4.7A)
 0.82A 1uwhB-5jznA:
23.6		 1uwhB-5jznA:
27.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWJ_A_BAXA1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 5jzn SERINE/THREONINE-PRO
TEIN KINASE DCLK1
(Homo
sapiens) 		6 / 12 VAL A 404
ALA A 417
GLU A 436
LEU A 502
HIS A 509
GLY A 532
 GUI  A 701 (-4.4A)
GUI  A 701 ( 3.9A)
None
None
None
GUI  A 701 ( 4.7A)
 0.77A 1uwjA-5jznA:
7.1		 1uwjA-5jznA:
27.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWJ_B_BAXB1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 4e93 TYROSINE-PROTEIN
KINASE FES/FPS
(Homo
sapiens) 		6 / 12 ILE A 567
VAL A 575
ALA A 588
GLU A 607
LEU A 674
HIS A 681
 GUI  A 901 (-4.0A)
GUI  A 901 (-4.5A)
GUI  A 901 (-3.4A)
None
None
None
 1.10A 1uwjB-4e93A:
28.7		 1uwjB-4e93A:
25.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWJ_B_BAXB1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 5jzn SERINE/THREONINE-PRO
TEIN KINASE DCLK1
(Homo
sapiens) 		7 / 12 ILE A 396
VAL A 404
ALA A 417
GLU A 436
LEU A 502
HIS A 509
GLY A 532
 GUI  A 701 (-4.1A)
GUI  A 701 (-4.4A)
GUI  A 701 ( 3.9A)
None
None
None
GUI  A 701 ( 4.7A)
 0.89A 1uwjB-5jznA:
7.1		 1uwjB-5jznA:
27.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XKK_A_FMMA91_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4e93 TYROSINE-PROTEIN
KINASE FES/FPS
(Homo
sapiens) 		7 / 12 ALA A 588
GLY A 642
LEU A 645
ARG A 649
LEU A 690
ASP A 701
PHE A 702
 GUI  A 901 (-3.4A)
GUI  A 901 (-3.5A)
None
None
GUI  A 901 (-4.3A)
GUI  A 901 ( 4.1A)
None
 0.83A 1xkkA-4e93A:
31.7		 1xkkA-4e93A:
25.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2EUF_B_LQQB401_1
(CELL DIVISION
PROTEIN KINASE 6)		 5jzn SERINE/THREONINE-PRO
TEIN KINASE DCLK1
(Homo
sapiens) 		7 / 12 VAL A 404
VAL A 449
VAL A 468
ASP A 472
ASN A 516
LEU A 518
ASP A 533
 GUI  A 701 (-4.4A)
None
GUI  A 701 (-4.0A)
None
GUI  A 701 (-4.4A)
GUI  A 701 (-4.4A)
GUI  A 701 ( 4.8A)
 0.74A 2eufB-5jznA:
27.4		 2eufB-5jznA:
32.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_A_MIXA539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 5jzn SERINE/THREONINE-PRO
TEIN KINASE DCLK1
(Homo
sapiens) 		7 / 12 VAL A 404
ALA A 417
VAL A 468
ASP A 511
LYS A 513
ASN A 516
ASP A 533
 GUI  A 701 (-4.4A)
GUI  A 701 ( 3.9A)
GUI  A 701 (-4.0A)
None
None
GUI  A 701 (-4.4A)
GUI  A 701 ( 4.8A)
 0.74A 2fumA-5jznA:
22.3		 2fumA-5jznA:
25.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_B_MIXB1539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 5jzn SERINE/THREONINE-PRO
TEIN KINASE DCLK1
(Homo
sapiens) 		7 / 12 VAL A 404
ALA A 417
MET A 465
VAL A 468
LYS A 513
ASN A 516
ASP A 533
 GUI  A 701 (-4.4A)
GUI  A 701 ( 3.9A)
GUI  A 701 ( 4.1A)
GUI  A 701 (-4.0A)
None
GUI  A 701 (-4.4A)
GUI  A 701 ( 4.8A)
 0.74A 2fumB-5jznA:
27.4		 2fumB-5jznA:
25.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ITO_A_IREA2020_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 5jzn SERINE/THREONINE-PRO
TEIN KINASE DCLK1
(Homo
sapiens) 		7 / 12 ALA A 417
LYS A 419
GLU A 436
LEU A 463
GLY A 471
ASP A 475
LEU A 518
 GUI  A 701 ( 3.9A)
GUI  A 701 (-3.1A)
None
None
GUI  A 701 (-3.6A)
GUI  A 701 (-4.1A)
GUI  A 701 (-4.4A)
 0.73A 2itoA-5jznA:
24.0		 2itoA-5jznA:
25.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ITY_A_IREA2020_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 5jzn SERINE/THREONINE-PRO
TEIN KINASE DCLK1
(Homo
sapiens) 		8 / 12 GLY A 397
VAL A 404
ALA A 417
LYS A 419
GLU A 436
LEU A 463
GLY A 471
LEU A 518
 GUI  A 701 ( 3.8A)
GUI  A 701 (-4.4A)
GUI  A 701 ( 3.9A)
GUI  A 701 (-3.1A)
None
None
GUI  A 701 (-3.6A)
GUI  A 701 (-4.4A)
 0.71A 2ityA-5jznA:
24.1		 2ityA-5jznA:
26.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XP2_A_VGHA9000_1
(TYROSINE-PROTEIN
KINASE RECEPTOR)		 5jzn SERINE/THREONINE-PRO
TEIN KINASE DCLK1
(Homo
sapiens) 		6 / 9 VAL A 404
ALA A 417
GLY A 471
LEU A 518
GLY A 532
ASP A 533
 GUI  A 701 (-4.4A)
GUI  A 701 ( 3.9A)
GUI  A 701 (-3.6A)
GUI  A 701 (-4.4A)
GUI  A 701 ( 4.7A)
GUI  A 701 ( 4.8A)
 0.65A 2xp2A-5jznA:
7.7		 2xp2A-5jznA:
26.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2Y6O_A_1N1A1892_1
(EPHRIN TYPE-A
RECEPTOR 4)		 4e93 TYROSINE-PROTEIN
KINASE FES/FPS
(Homo
sapiens) 		8 / 12 ILE A 567
ALA A 588
LYS A 590
GLU A 607
ILE A 634
GLY A 642
LEU A 690
SER A 700
 GUI  A 901 (-4.0A)
GUI  A 901 (-3.4A)
GUI  A 901 (-2.8A)
None
None
GUI  A 901 (-3.5A)
GUI  A 901 (-4.3A)
GUI  A 901 (-3.1A)
 0.82A 2y6oA-4e93A:
34.9		 2y6oA-4e93A:
33.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7J_A_B49A1294_1
(PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM)		 4e93 TYROSINE-PROTEIN
KINASE FES/FPS
(Homo
sapiens) 		7 / 12 ILE A 567
VAL A 575
ALA A 588
LEU A 638
GLY A 642
LEU A 690
ASP A 701
 GUI  A 901 (-4.0A)
GUI  A 901 (-4.5A)
GUI  A 901 (-3.4A)
GUI  A 901 (-4.4A)
GUI  A 901 (-3.5A)
GUI  A 901 (-4.3A)
GUI  A 901 ( 4.1A)
 0.73A 2y7jA-4e93A:
19.8		 2y7jA-4e93A:
25.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2Y7J_A_B49A1294_1
(PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM)		 5jzn SERINE/THREONINE-PRO
TEIN KINASE DCLK1
(Homo
sapiens) 		6 / 12 ILE A 396
VAL A 404
ALA A 417
LEU A 467
GLY A 471
LEU A 518
 GUI  A 701 (-4.1A)
GUI  A 701 (-4.4A)
GUI  A 701 ( 3.9A)
GUI  A 701 ( 4.7A)
GUI  A 701 (-3.6A)
GUI  A 701 (-4.4A)
 0.40A 2y7jA-5jznA:
31.7		 2y7jA-5jznA:
31.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7J_B_B49B1294_1
(PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM)		 4e93 TYROSINE-PROTEIN
KINASE FES/FPS
(Homo
sapiens) 		6 / 10 ILE A 567
VAL A 575
ALA A 588
LEU A 638
GLY A 642
LEU A 690
 GUI  A 901 (-4.0A)
GUI  A 901 (-4.5A)
GUI  A 901 (-3.4A)
GUI  A 901 (-4.4A)
GUI  A 901 (-3.5A)
GUI  A 901 (-4.3A)
 0.57A 2y7jB-4e93A:
20.4		 2y7jB-4e93A:
25.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2Y7J_B_B49B1294_1
(PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM)		 5jzn SERINE/THREONINE-PRO
TEIN KINASE DCLK1
(Homo
sapiens) 		6 / 10 ILE A 396
VAL A 404
ALA A 417
LEU A 467
GLY A 471
LEU A 518
 GUI  A 701 (-4.1A)
GUI  A 701 (-4.4A)
GUI  A 701 ( 3.9A)
GUI  A 701 ( 4.7A)
GUI  A 701 (-3.6A)
GUI  A 701 (-4.4A)
 0.46A 2y7jB-5jznA:
35.1		 2y7jB-5jznA:
31.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7J_C_B49C1294_1
(PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM)		 4e93 TYROSINE-PROTEIN
KINASE FES/FPS
(Homo
sapiens) 		6 / 10 ILE A 567
VAL A 575
ALA A 588
LEU A 638
GLY A 642
LEU A 690
 GUI  A 901 (-4.0A)
GUI  A 901 (-4.5A)
GUI  A 901 (-3.4A)
GUI  A 901 (-4.4A)
GUI  A 901 (-3.5A)
GUI  A 901 (-4.3A)
 0.59A 2y7jC-4e93A:
26.3		 2y7jC-4e93A:
25.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2Y7J_C_B49C1294_1
(PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM)		 5jzn SERINE/THREONINE-PRO
TEIN KINASE DCLK1
(Homo
sapiens) 		7 / 10 ILE A 396
VAL A 404
ALA A 417
LEU A 467
GLY A 471
ASP A 475
LEU A 518
 GUI  A 701 (-4.1A)
GUI  A 701 (-4.4A)
GUI  A 701 ( 3.9A)
GUI  A 701 ( 4.7A)
GUI  A 701 (-3.6A)
GUI  A 701 (-4.1A)
GUI  A 701 (-4.4A)
 0.48A 2y7jC-5jznA:
31.9		 2y7jC-5jznA:
31.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7J_D_B49D1294_1
(PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM)		 4e93 TYROSINE-PROTEIN
KINASE FES/FPS
(Homo
sapiens) 		6 / 10 ILE A 567
VAL A 575
ALA A 588
LEU A 638
GLY A 642
LEU A 690
 GUI  A 901 (-4.0A)
GUI  A 901 (-4.5A)
GUI  A 901 (-3.4A)
GUI  A 901 (-4.4A)
GUI  A 901 (-3.5A)
GUI  A 901 (-4.3A)
 0.55A 2y7jD-4e93A:
20.3		 2y7jD-4e93A:
25.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2Y7J_D_B49D1294_1
(PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM)		 5jzn SERINE/THREONINE-PRO
TEIN KINASE DCLK1
(Homo
sapiens) 		7 / 10 ILE A 396
VAL A 404
ALA A 417
LEU A 467
GLY A 471
ASP A 475
LEU A 518
 GUI  A 701 (-4.1A)
GUI  A 701 (-4.4A)
GUI  A 701 ( 3.9A)
GUI  A 701 ( 4.7A)
GUI  A 701 (-3.6A)
GUI  A 701 (-4.1A)
GUI  A 701 (-4.4A)
 0.55A 2y7jD-5jznA:
34.9		 2y7jD-5jznA:
31.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ZVA_A_1N1A513_1
(TYROSINE-PROTEIN
KINASE LYN)		 4e93 TYROSINE-PROTEIN
KINASE FES/FPS
(Homo
sapiens) 		7 / 12 ALA A 588
LYS A 590
GLU A 607
VAL A 620
ILE A 634
GLY A 642
LEU A 690
 GUI  A 901 (-3.4A)
GUI  A 901 (-2.8A)
None
None
None
GUI  A 901 (-3.5A)
GUI  A 901 (-4.3A)
 0.63A 2zvaA-4e93A:
35.9		 2zvaA-4e93A:
32.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3AOX_A_EMHA901_1
(ALK TYROSINE KINASE
RECEPTOR)		 4e93 TYROSINE-PROTEIN
KINASE FES/FPS
(Homo
sapiens) 		6 / 10 ALA A 588
LYS A 590
VAL A 620
LEU A 638
GLY A 642
LEU A 690
 GUI  A 901 (-3.4A)
GUI  A 901 (-2.8A)
None
GUI  A 901 (-4.4A)
GUI  A 901 (-3.5A)
GUI  A 901 (-4.3A)
 0.53A 3aoxA-4e93A:
32.9		 3aoxA-4e93A:
34.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AOX_A_EMHA901_1
(ALK TYROSINE KINASE
RECEPTOR)		 5jzn SERINE/THREONINE-PRO
TEIN KINASE DCLK1
(Homo
sapiens) 		7 / 10 ARG A 394
ALA A 417
LYS A 419
VAL A 449
LEU A 467
GLY A 471
LEU A 518
 None
GUI  A 701 ( 3.9A)
GUI  A 701 (-3.1A)
None
GUI  A 701 ( 4.7A)
GUI  A 701 (-3.6A)
GUI  A 701 (-4.4A)
 0.68A 3aoxA-5jznA:
22.5		 3aoxA-5jznA:
26.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BBT_B_FMMB91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		 4e93 TYROSINE-PROTEIN
KINASE FES/FPS
(Homo
sapiens) 		6 / 12 VAL A 575
ALA A 588
LEU A 622
LEU A 638
GLY A 642
LEU A 690
 GUI  A 901 (-4.5A)
GUI  A 901 (-3.4A)
None
GUI  A 901 (-4.4A)
GUI  A 901 (-3.5A)
GUI  A 901 (-4.3A)
 0.67A 3bbtB-4e93A:
31.2		 3bbtB-4e93A:
27.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BBT_B_FMMB91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		 4e93 TYROSINE-PROTEIN
KINASE FES/FPS
(Homo
sapiens) 		7 / 12 VAL A 575
ALA A 588
LEU A 638
GLY A 642
LEU A 690
ASP A 701
PHE A 702
 GUI  A 901 (-4.5A)
GUI  A 901 (-3.4A)
GUI  A 901 (-4.4A)
GUI  A 901 (-3.5A)
GUI  A 901 (-4.3A)
GUI  A 901 ( 4.1A)
None
 0.93A 3bbtB-4e93A:
31.2		 3bbtB-4e93A:
27.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BBT_B_FMMB91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		 5jzn SERINE/THREONINE-PRO
TEIN KINASE DCLK1
(Homo
sapiens) 		6 / 12 VAL A 404
ALA A 417
LEU A 451
LEU A 467
GLY A 471
LEU A 518
 GUI  A 701 (-4.4A)
GUI  A 701 ( 3.9A)
None
GUI  A 701 ( 4.7A)
GUI  A 701 (-3.6A)
GUI  A 701 (-4.4A)
 0.55A 3bbtB-5jznA:
22.1		 3bbtB-5jznA:
25.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C7Q_A_XINA1172_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 5jzn SERINE/THREONINE-PRO
TEIN KINASE DCLK1
(Homo
sapiens) 		7 / 12 GLY A 397
GLU A 406
ALA A 417
LYS A 419
VAL A 449
GLY A 471
LEU A 518
 GUI  A 701 ( 3.8A)
GUI  A 701 ( 4.7A)
GUI  A 701 ( 3.9A)
GUI  A 701 (-3.1A)
None
GUI  A 701 (-3.6A)
GUI  A 701 (-4.4A)
 0.55A 3c7qA-5jznA:
21.6		 3c7qA-5jznA:
27.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3HEC_A_STIA1_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 5jzn SERINE/THREONINE-PRO
TEIN KINASE DCLK1
(Homo
sapiens) 		5 / 12 ALA A 417
LYS A 419
GLU A 436
LEU A 440
LEU A 467
 GUI  A 701 ( 3.9A)
GUI  A 701 (-3.1A)
None
None
GUI  A 701 ( 4.7A)
 0.76A 3hecA-5jznA:
23.4		 3hecA-5jznA:
30.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K54_A_1N1A1_1
(TYROSINE-PROTEIN
KINASE BTK)		 4e93 TYROSINE-PROTEIN
KINASE FES/FPS
(Homo
sapiens) 		8 / 12 ALA A 588
LYS A 590
GLU A 607
VAL A 620
ILE A 634
GLY A 642
LEU A 690
SER A 700
 GUI  A 901 (-3.4A)
GUI  A 901 (-2.8A)
None
None
None
GUI  A 901 (-3.5A)
GUI  A 901 (-4.3A)
GUI  A 901 (-3.1A)
 0.77A 3k54A-4e93A:
33.4		 3k54A-4e93A:
31.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LFA_A_1N1A361_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 5jzn SERINE/THREONINE-PRO
TEIN KINASE DCLK1
(Homo
sapiens) 		5 / 8 ALA A 417
LYS A 419
GLU A 436
LEU A 463
LEU A 467
 GUI  A 701 ( 3.9A)
GUI  A 701 (-3.1A)
None
None
GUI  A 701 ( 4.7A)
 0.61A 3lfaA-5jznA:
23.4		 3lfaA-5jznA:
30.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MIY_A_B49A1_1
(TYROSINE-PROTEIN
KINASE ITK/TSK)		 4e93 TYROSINE-PROTEIN
KINASE FES/FPS
(Homo
sapiens) 		7 / 11 ILE A 567
ALA A 588
LYS A 590
GLY A 642
LEU A 690
SER A 700
ASP A 701
 GUI  A 901 (-4.0A)
GUI  A 901 (-3.4A)
GUI  A 901 (-2.8A)
GUI  A 901 (-3.5A)
GUI  A 901 (-4.3A)
GUI  A 901 (-3.1A)
GUI  A 901 ( 4.1A)
 0.75A 3miyA-4e93A:
35.0		 3miyA-4e93A:
34.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MIY_A_B49A1_1
(TYROSINE-PROTEIN
KINASE ITK/TSK)		 4e93 TYROSINE-PROTEIN
KINASE FES/FPS
(Homo
sapiens) 		7 / 11 ILE A 567
ALA A 588
LYS A 590
VAL A 620
GLY A 642
LEU A 690
SER A 700
 GUI  A 901 (-4.0A)
GUI  A 901 (-3.4A)
GUI  A 901 (-2.8A)
None
GUI  A 901 (-3.5A)
GUI  A 901 (-4.3A)
GUI  A 901 (-3.1A)
 0.64A 3miyA-4e93A:
35.0		 3miyA-4e93A:
34.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MIY_A_B49A1_1
(TYROSINE-PROTEIN
KINASE ITK/TSK)		 5jzn SERINE/THREONINE-PRO
TEIN KINASE DCLK1
(Homo
sapiens) 		6 / 11 ILE A 396
ALA A 417
LYS A 419
VAL A 449
GLY A 471
LEU A 518
 GUI  A 701 (-4.1A)
GUI  A 701 ( 3.9A)
GUI  A 701 (-3.1A)
None
GUI  A 701 (-3.6A)
GUI  A 701 (-4.4A)
 0.80A 3miyA-5jznA:
23.3		 3miyA-5jznA:
25.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MIY_B_B49B2_1
(TYROSINE-PROTEIN
KINASE ITK/TSK)		 4e93 TYROSINE-PROTEIN
KINASE FES/FPS
(Homo
sapiens) 		6 / 9 ILE A 567
ALA A 588
LYS A 590
GLY A 642
LEU A 690
SER A 700
 GUI  A 901 (-4.0A)
GUI  A 901 (-3.4A)
GUI  A 901 (-2.8A)
GUI  A 901 (-3.5A)
GUI  A 901 (-4.3A)
GUI  A 901 (-3.1A)
 0.64A 3miyB-4e93A:
34.8		 3miyB-4e93A:
34.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MIY_B_B49B2_1
(TYROSINE-PROTEIN
KINASE ITK/TSK)		 5jzn SERINE/THREONINE-PRO
TEIN KINASE DCLK1
(Homo
sapiens) 		5 / 9 ILE A 396
ALA A 417
LYS A 419
GLY A 471
LEU A 518
 GUI  A 701 (-4.1A)
GUI  A 701 ( 3.9A)
GUI  A 701 (-3.1A)
GUI  A 701 (-3.6A)
GUI  A 701 (-4.4A)
 0.72A 3miyB-5jznA:
23.2		 3miyB-5jznA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OG7_A_032A1_1
(AKAP9-BRAF FUSION
PROTEIN)		 4e93 TYROSINE-PROTEIN
KINASE FES/FPS
(Homo
sapiens) 		6 / 12 ILE A 567
VAL A 575
ALA A 588
LYS A 590
LEU A 611
PHE A 702
 GUI  A 901 (-4.0A)
GUI  A 901 (-4.5A)
GUI  A 901 (-3.4A)
GUI  A 901 (-2.8A)
None
None
 1.29A 3og7A-4e93A:
29.1		 3og7A-4e93A:
27.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3SXR_A_1N1A1_1
(CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX)		 4e93 TYROSINE-PROTEIN
KINASE FES/FPS
(Homo
sapiens) 		6 / 12 VAL A 575
ALA A 588
VAL A 620
ILE A 634
GLY A 642
LEU A 690
 GUI  A 901 (-4.5A)
GUI  A 901 (-3.4A)
None
None
GUI  A 901 (-3.5A)
GUI  A 901 (-4.3A)
 0.39A 3sxrA-4e93A:
33.6		 3sxrA-4e93A:
37.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TI1_A_B49A299_1
(CYCLIN-DEPENDENT
KINASE 2)		 4e93 TYROSINE-PROTEIN
KINASE FES/FPS
(Homo
sapiens) 		5 / 9 ILE A 567
ALA A 588
VAL A 620
ASP A 643
LEU A 690
 GUI  A 901 (-4.0A)
GUI  A 901 (-3.4A)
None
GUI  A 901 ( 4.8A)
GUI  A 901 (-4.3A)
 0.41A 3ti1A-4e93A:
23.9		 3ti1A-4e93A:
22.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TI1_A_B49A299_1
(CYCLIN-DEPENDENT
KINASE 2)		 5jzn SERINE/THREONINE-PRO
TEIN KINASE DCLK1
(Homo
sapiens) 		5 / 9 ILE A 396
ALA A 417
VAL A 449
ASP A 472
LEU A 518
 GUI  A 701 (-4.1A)
GUI  A 701 ( 3.9A)
None
None
GUI  A 701 (-4.4A)
 0.68A 3ti1A-5jznA:
24.3		 3ti1A-5jznA:
32.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UG2_A_IREA1_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 5jzn SERINE/THREONINE-PRO
TEIN KINASE DCLK1
(Homo
sapiens) 		8 / 12 VAL A 404
ALA A 417
LEU A 463
MET A 465
LEU A 467
GLY A 471
ASP A 475
LEU A 518
 GUI  A 701 (-4.4A)
GUI  A 701 ( 3.9A)
None
GUI  A 701 ( 4.1A)
GUI  A 701 ( 4.7A)
GUI  A 701 (-3.6A)
GUI  A 701 (-4.1A)
GUI  A 701 (-4.4A)
 0.62A 3ug2A-5jznA:
23.7		 3ug2A-5jznA:
26.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V5W_A_8PRA701_1
(G-PROTEIN COUPLED
RECEPTOR KINASE 2)		 4e93 TYROSINE-PROTEIN
KINASE FES/FPS
(Homo
sapiens) 		6 / 12 ILE A 567
GLY A 573
VAL A 575
ALA A 588
LYS A 590
ASP A 701
 GUI  A 901 (-4.0A)
None
GUI  A 901 (-4.5A)
GUI  A 901 (-3.4A)
GUI  A 901 (-2.8A)
GUI  A 901 ( 4.1A)
 0.79A 3v5wA-4e93A:
8.0		 3v5wA-4e93A:
21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_2
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 4e93 TYROSINE-PROTEIN
KINASE FES/FPS
(Homo
sapiens) 		4 / 5 ILE A 610
VAL A 620
LEU A 690
ASP A 701
 None
None
GUI  A 901 (-4.3A)
GUI  A 901 ( 4.1A)
 0.80A 3wzdA-4e93A:
32.5		 3wzdA-4e93A:
29.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ZBF_A_VGHA3000_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ROS)		 4e93 TYROSINE-PROTEIN
KINASE FES/FPS
(Homo
sapiens) 		7 / 12 ALA A 588
LEU A 638
GLY A 642
ASP A 643
THR A 646
LEU A 690
ASP A 701
 GUI  A 901 (-3.4A)
GUI  A 901 (-4.4A)
GUI  A 901 (-3.5A)
GUI  A 901 ( 4.8A)
GUI  A 901 ( 3.8A)
GUI  A 901 (-4.3A)
GUI  A 901 ( 4.1A)
 0.59A 3zbfA-4e93A:
35.0		 3zbfA-4e93A:
35.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZBF_A_VGHA3000_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ROS)		 5jzn SERINE/THREONINE-PRO
TEIN KINASE DCLK1
(Homo
sapiens) 		7 / 12 ALA A 417
LEU A 467
GLY A 471
ASP A 472
LEU A 518
GLY A 532
ASP A 533
 GUI  A 701 ( 3.9A)
GUI  A 701 ( 4.7A)
GUI  A 701 (-3.6A)
None
GUI  A 701 (-4.4A)
GUI  A 701 ( 4.7A)
GUI  A 701 ( 4.8A)
 0.65A 3zbfA-5jznA:
24.4		 3zbfA-5jznA:
27.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AG8_A_AXIA2000_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 5jzn SERINE/THREONINE-PRO
TEIN KINASE DCLK1
(Homo
sapiens) 		7 / 12 VAL A 404
ALA A 417
LYS A 419
GLU A 436
VAL A 449
GLY A 471
LEU A 518
 GUI  A 701 (-4.4A)
GUI  A 701 ( 3.9A)
GUI  A 701 (-3.1A)
None
None
GUI  A 701 (-3.6A)
GUI  A 701 (-4.4A)
 0.79A 4ag8A-5jznA:
21.9		 4ag8A-5jznA:
27.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AGD_A_B49A2000_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 5jzn SERINE/THREONINE-PRO
TEIN KINASE DCLK1
(Homo
sapiens) 		5 / 11 ALA A 417
LYS A 419
VAL A 449
GLY A 471
LEU A 518
 GUI  A 701 ( 3.9A)
GUI  A 701 (-3.1A)
None
GUI  A 701 (-3.6A)
GUI  A 701 (-4.4A)
 0.53A 4agdA-5jznA:
21.3		 4agdA-5jznA:
25.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ASD_A_BAXA1500_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 5jzn SERINE/THREONINE-PRO
TEIN KINASE DCLK1
(Homo
sapiens) 		8 / 12 VAL A 404
ALA A 417
LYS A 419
GLU A 436
LEU A 440
GLY A 471
LEU A 502
HIS A 509
 GUI  A 701 (-4.4A)
GUI  A 701 ( 3.9A)
GUI  A 701 (-3.1A)
None
None
GUI  A 701 (-3.6A)
None
None
 0.97A 4asdA-5jznA:
21.8		 4asdA-5jznA:
25.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I22_A_IREA9001_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 5jzn SERINE/THREONINE-PRO
TEIN KINASE DCLK1
(Homo
sapiens) 		9 / 12 GLY A 397
VAL A 404
ALA A 417
LEU A 463
MET A 465
GLY A 471
ASP A 475
LEU A 518
ASP A 533
 GUI  A 701 ( 3.8A)
GUI  A 701 (-4.4A)
GUI  A 701 ( 3.9A)
None
GUI  A 701 ( 4.1A)
GUI  A 701 (-3.6A)
GUI  A 701 (-4.1A)
GUI  A 701 (-4.4A)
GUI  A 701 ( 4.8A)
 0.75A 4i22A-5jznA:
22.1		 4i22A-5jznA:
26.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I22_A_IREA9001_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 5jzn SERINE/THREONINE-PRO
TEIN KINASE DCLK1
(Homo
sapiens) 		9 / 12 GLY A 397
VAL A 404
ALA A 417
LYS A 419
LEU A 463
GLY A 471
ASP A 475
LEU A 518
ASP A 533
 GUI  A 701 ( 3.8A)
GUI  A 701 (-4.4A)
GUI  A 701 ( 3.9A)
GUI  A 701 (-3.1A)
None
GUI  A 701 (-3.6A)
GUI  A 701 (-4.1A)
GUI  A 701 (-4.4A)
GUI  A 701 ( 4.8A)
 1.02A 4i22A-5jznA:
22.1		 4i22A-5jznA:
26.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I41_A_MIXA500_1
(SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 4e93 TYROSINE-PROTEIN
KINASE FES/FPS
(Homo
sapiens) 		7 / 12 VAL A 575
ALA A 588
ASP A 643
ASP A 683
ASN A 688
LEU A 690
ASP A 701
 GUI  A 901 (-4.5A)
GUI  A 901 (-3.4A)
GUI  A 901 ( 4.8A)
None
GUI  A 901 (-4.6A)
GUI  A 901 (-4.3A)
GUI  A 901 ( 4.1A)
 0.71A 4i41A-4e93A:
24.1		 4i41A-4e93A:
26.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I41_A_MIXA500_1
(SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 5jzn SERINE/THREONINE-PRO
TEIN KINASE DCLK1
(Homo
sapiens) 		9 / 12 VAL A 404
ALA A 417
ASP A 472
ASP A 475
ASP A 511
LYS A 513
ASN A 516
LEU A 518
ASP A 533
 GUI  A 701 (-4.4A)
GUI  A 701 ( 3.9A)
None
GUI  A 701 (-4.1A)
None
None
GUI  A 701 (-4.4A)
GUI  A 701 (-4.4A)
GUI  A 701 ( 4.8A)
 0.53A 4i41A-5jznA:
29.0		 4i41A-5jznA:
29.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IAA_A_RTZA401_1
(SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 5jzn SERINE/THREONINE-PRO
TEIN KINASE DCLK1
(Homo
sapiens) 		6 / 11 VAL A 404
ALA A 417
ASP A 472
GLU A 515
LEU A 518
ASP A 533
 GUI  A 701 (-4.4A)
GUI  A 701 ( 3.9A)
None
None
GUI  A 701 (-4.4A)
GUI  A 701 ( 4.8A)
 0.82A 4iaaA-5jznA:
28.8		 4iaaA-5jznA:
29.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IFG_A_1E8A601_1
(CALMODULIN-DOMAIN
PROTEIN KINASE 1)		 5jzn SERINE/THREONINE-PRO
TEIN KINASE DCLK1
(Homo
sapiens) 		7 / 12 GLY A 397
VAL A 404
ALA A 417
LEU A 451
LEU A 463
GLY A 471
LEU A 518
 GUI  A 701 ( 3.8A)
GUI  A 701 (-4.4A)
GUI  A 701 ( 3.9A)
None
None
GUI  A 701 (-3.6A)
GUI  A 701 (-4.4A)
 0.58A 4ifgA-5jznA:
26.3		 4ifgA-5jznA:
25.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KS8_A_B49A701_1
(SERINE/THREONINE-PRO
TEIN KINASE PAK 6)		 4e93 TYROSINE-PROTEIN
KINASE FES/FPS
(Homo
sapiens) 		6 / 10 ILE A 567
ALA A 588
VAL A 620
GLY A 642
LEU A 690
SER A 700
 GUI  A 901 (-4.0A)
GUI  A 901 (-3.4A)
None
GUI  A 901 (-3.5A)
GUI  A 901 (-4.3A)
GUI  A 901 (-3.1A)
 0.50A 4ks8A-4e93A:
20.8		 4ks8A-4e93A:
24.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KS8_A_B49A701_1
(SERINE/THREONINE-PRO
TEIN KINASE PAK 6)		 4e93 TYROSINE-PROTEIN
KINASE FES/FPS
(Homo
sapiens) 		6 / 10 ILE A 567
ALA A 588
VAL A 620
MET A 636
GLY A 642
LEU A 690
 GUI  A 901 (-4.0A)
GUI  A 901 (-3.4A)
None
GUI  A 901 ( 4.8A)
GUI  A 901 (-3.5A)
GUI  A 901 (-4.3A)
 0.53A 4ks8A-4e93A:
20.8		 4ks8A-4e93A:
24.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KS8_A_B49A701_1
(SERINE/THREONINE-PRO
TEIN KINASE PAK 6)		 5jzn SERINE/THREONINE-PRO
TEIN KINASE DCLK1
(Homo
sapiens) 		6 / 10 ILE A 396
ALA A 417
VAL A 449
MET A 465
GLY A 471
LEU A 518
 GUI  A 701 (-4.1A)
GUI  A 701 ( 3.9A)
None
GUI  A 701 ( 4.1A)
GUI  A 701 (-3.6A)
GUI  A 701 (-4.4A)
 0.46A 4ks8A-5jznA:
26.8		 4ks8A-5jznA:
30.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MKC_A_4MKA1503_1
(ALK TYROSINE KINASE
RECEPTOR)		 4e93 TYROSINE-PROTEIN
KINASE FES/FPS
(Homo
sapiens) 		9 / 12 GLY A 570
VAL A 575
ALA A 588
LYS A 590
LEU A 638
GLY A 642
ASP A 643
LEU A 690
ASP A 701
 GUI  A 901 (-3.4A)
GUI  A 901 (-4.5A)
GUI  A 901 (-3.4A)
GUI  A 901 (-2.8A)
GUI  A 901 (-4.4A)
GUI  A 901 (-3.5A)
GUI  A 901 ( 4.8A)
GUI  A 901 (-4.3A)
GUI  A 901 ( 4.1A)
 0.46A 4mkcA-4e93A:
34.4		 4mkcA-4e93A:
36.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXO_B_DB8B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4e93 TYROSINE-PROTEIN
KINASE FES/FPS
(Homo
sapiens) 		8 / 12 VAL A 575
ALA A 588
GLU A 607
VAL A 620
ILE A 634
GLY A 642
LEU A 690
ASP A 701
 GUI  A 901 (-4.5A)
GUI  A 901 (-3.4A)
None
None
None
GUI  A 901 (-3.5A)
GUI  A 901 (-4.3A)
GUI  A 901 ( 4.1A)
 0.81A 4mxoB-4e93A:
35.5		 4mxoB-4e93A:
32.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXY_A_DB8A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4e93 TYROSINE-PROTEIN
KINASE FES/FPS
(Homo
sapiens) 		8 / 12 VAL A 575
ALA A 588
VAL A 620
ILE A 634
MET A 636
GLY A 642
LEU A 690
ASP A 701
 GUI  A 901 (-4.5A)
GUI  A 901 (-3.4A)
None
None
GUI  A 901 ( 4.8A)
GUI  A 901 (-3.5A)
GUI  A 901 (-4.3A)
GUI  A 901 ( 4.1A)
 0.53A 4mxyA-4e93A:
28.4		 4mxyA-4e93A:
33.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXY_A_DB8A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4e93 TYROSINE-PROTEIN
KINASE FES/FPS
(Homo
sapiens) 		8 / 12 VAL A 575
GLU A 607
VAL A 620
ILE A 634
MET A 636
GLY A 642
LEU A 690
ASP A 701
 GUI  A 901 (-4.5A)
None
None
None
GUI  A 901 ( 4.8A)
GUI  A 901 (-3.5A)
GUI  A 901 (-4.3A)
GUI  A 901 ( 4.1A)
 0.62A 4mxyA-4e93A:
28.4		 4mxyA-4e93A:
33.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MXY_A_DB8A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 5jzn SERINE/THREONINE-PRO
TEIN KINASE DCLK1
(Homo
sapiens) 		8 / 12 VAL A 404
ALA A 417
GLU A 436
VAL A 449
MET A 465
GLY A 471
LEU A 518
ASP A 533
 GUI  A 701 (-4.4A)
GUI  A 701 ( 3.9A)
None
None
GUI  A 701 ( 4.1A)
GUI  A 701 (-3.6A)
GUI  A 701 (-4.4A)
GUI  A 701 ( 4.8A)
 0.68A 4mxyA-5jznA:
25.3		 4mxyA-5jznA:
28.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXY_B_DB8B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4e93 TYROSINE-PROTEIN
KINASE FES/FPS
(Homo
sapiens) 		8 / 12 VAL A 575
ALA A 588
GLU A 607
VAL A 620
MET A 636
GLY A 642
LEU A 690
ASP A 701
 GUI  A 901 (-4.5A)
GUI  A 901 (-3.4A)
None
None
GUI  A 901 ( 4.8A)
GUI  A 901 (-3.5A)
GUI  A 901 (-4.3A)
GUI  A 901 ( 4.1A)
 0.51A 4mxyB-4e93A:
28.5		 4mxyB-4e93A:
33.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXZ_A_DB8A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4e93 TYROSINE-PROTEIN
KINASE FES/FPS
(Homo
sapiens) 		8 / 12 VAL A 575
ALA A 588
VAL A 620
ILE A 634
MET A 636
GLY A 642
LEU A 690
ASP A 701
 GUI  A 901 (-4.5A)
GUI  A 901 (-3.4A)
None
None
GUI  A 901 ( 4.8A)
GUI  A 901 (-3.5A)
GUI  A 901 (-4.3A)
GUI  A 901 ( 4.1A)
 0.53A 4mxzA-4e93A:
28.4		 4mxzA-4e93A:
33.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXZ_A_DB8A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4e93 TYROSINE-PROTEIN
KINASE FES/FPS
(Homo
sapiens) 		8 / 12 VAL A 575
GLU A 607
VAL A 620
ILE A 634
MET A 636
GLY A 642
LEU A 690
ASP A 701
 GUI  A 901 (-4.5A)
None
None
None
GUI  A 901 ( 4.8A)
GUI  A 901 (-3.5A)
GUI  A 901 (-4.3A)
GUI  A 901 ( 4.1A)
 0.62A 4mxzA-4e93A:
28.4		 4mxzA-4e93A:
33.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MXZ_A_DB8A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 5jzn SERINE/THREONINE-PRO
TEIN KINASE DCLK1
(Homo
sapiens) 		8 / 12 VAL A 404
ALA A 417
GLU A 436
VAL A 449
MET A 465
GLY A 471
LEU A 518
ASP A 533
 GUI  A 701 (-4.4A)
GUI  A 701 ( 3.9A)
None
None
GUI  A 701 ( 4.1A)
GUI  A 701 (-3.6A)
GUI  A 701 (-4.4A)
GUI  A 701 ( 4.8A)
 0.68A 4mxzA-5jznA:
25.3		 4mxzA-5jznA:
28.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXZ_B_DB8B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4e93 TYROSINE-PROTEIN
KINASE FES/FPS
(Homo
sapiens) 		8 / 12 VAL A 575
ALA A 588
GLU A 607
VAL A 620
MET A 636
GLY A 642
LEU A 690
ASP A 701
 GUI  A 901 (-4.5A)
GUI  A 901 (-3.4A)
None
None
GUI  A 901 ( 4.8A)
GUI  A 901 (-3.5A)
GUI  A 901 (-4.3A)
GUI  A 901 ( 4.1A)
 0.51A 4mxzB-4e93A:
28.5		 4mxzB-4e93A:
33.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OGR_A_ADNA401_1
(CYCLIN-DEPENDENT
KINASE 9)		 4e93 TYROSINE-PROTEIN
KINASE FES/FPS
(Homo
sapiens) 		5 / 8 ALA A 588
ASP A 643
ASN A 688
LEU A 690
ASP A 701
 GUI  A 901 (-3.4A)
GUI  A 901 ( 4.8A)
GUI  A 901 (-4.6A)
GUI  A 901 (-4.3A)
GUI  A 901 ( 4.1A)
 0.54A 4ogrA-4e93A:
27.3		 4ogrA-4e93A:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OGR_A_ADNA401_1
(CYCLIN-DEPENDENT
KINASE 9)		 4e93 TYROSINE-PROTEIN
KINASE FES/FPS
(Homo
sapiens) 		7 / 8 ILE A 567
GLY A 570
VAL A 575
ALA A 588
ASP A 643
ASN A 688
LEU A 690
 GUI  A 901 (-4.0A)
GUI  A 901 (-3.4A)
GUI  A 901 (-4.5A)
GUI  A 901 (-3.4A)
GUI  A 901 ( 4.8A)
GUI  A 901 (-4.6A)
GUI  A 901 (-4.3A)
 0.74A 4ogrA-4e93A:
27.3		 4ogrA-4e93A:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OGR_E_ADNE401_1
(CYCLIN-DEPENDENT
KINASE 9)		 4e93 TYROSINE-PROTEIN
KINASE FES/FPS
(Homo
sapiens) 		5 / 7 ALA A 588
ASP A 643
ASN A 688
LEU A 690
ASP A 701
 GUI  A 901 (-3.4A)
GUI  A 901 ( 4.8A)
GUI  A 901 (-4.6A)
GUI  A 901 (-4.3A)
GUI  A 901 ( 4.1A)
 0.53A 4ogrE-4e93A:
26.1		 4ogrE-4e93A:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OGR_I_ADNI401_1
(CYCLIN-DEPENDENT
KINASE 9)		 4e93 TYROSINE-PROTEIN
KINASE FES/FPS
(Homo
sapiens) 		6 / 9 ILE A 567
ALA A 588
ASP A 643
ASN A 688
LEU A 690
ASP A 701
 GUI  A 901 (-4.0A)
GUI  A 901 (-3.4A)
GUI  A 901 ( 4.8A)
GUI  A 901 (-4.6A)
GUI  A 901 (-4.3A)
GUI  A 901 ( 4.1A)
 0.77A 4ogrI-4e93A:
27.0		 4ogrI-4e93A:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OGR_I_ADNI401_1
(CYCLIN-DEPENDENT
KINASE 9)		 4e93 TYROSINE-PROTEIN
KINASE FES/FPS
(Homo
sapiens) 		7 / 9 ILE A 567
GLY A 570
VAL A 575
ALA A 588
ASP A 643
ASN A 688
LEU A 690
 GUI  A 901 (-4.0A)
GUI  A 901 (-3.4A)
GUI  A 901 (-4.5A)
GUI  A 901 (-3.4A)
GUI  A 901 ( 4.8A)
GUI  A 901 (-4.6A)
GUI  A 901 (-4.3A)
 0.78A 4ogrI-4e93A:
27.0		 4ogrI-4e93A:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OGR_I_ADNI401_1
(CYCLIN-DEPENDENT
KINASE 9)		 5jzn SERINE/THREONINE-PRO
TEIN KINASE DCLK1
(Homo
sapiens) 		6 / 9 VAL A 404
ALA A 417
ASP A 472
ASN A 516
LEU A 518
ASP A 533
 GUI  A 701 (-4.4A)
GUI  A 701 ( 3.9A)
None
GUI  A 701 (-4.4A)
GUI  A 701 (-4.4A)
GUI  A 701 ( 4.8A)
 0.77A 4ogrI-5jznA:
26.5		 4ogrI-5jznA:
28.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QMN_A_DB8A401_1
(SERINE/THREONINE-PRO
TEIN KINASE 24)		 4e93 TYROSINE-PROTEIN
KINASE FES/FPS
(Homo
sapiens) 		6 / 12 ILE A 567
ALA A 588
ILE A 634
MET A 636
LEU A 690
ASP A 701
 GUI  A 901 (-4.0A)
GUI  A 901 (-3.4A)
None
GUI  A 901 ( 4.8A)
GUI  A 901 (-4.3A)
GUI  A 901 ( 4.1A)
 0.66A 4qmnA-4e93A:
21.6		 4qmnA-4e93A:
25.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QMN_A_DB8A401_1
(SERINE/THREONINE-PRO
TEIN KINASE 24)		 5jzn SERINE/THREONINE-PRO
TEIN KINASE DCLK1
(Homo
sapiens) 		6 / 12 ILE A 396
ALA A 417
GLU A 436
MET A 465
LEU A 518
ASP A 533
 GUI  A 701 (-4.1A)
GUI  A 701 ( 3.9A)
None
GUI  A 701 ( 4.1A)
GUI  A 701 (-4.4A)
GUI  A 701 ( 4.8A)
 0.78A 4qmnA-5jznA:
29.3		 4qmnA-5jznA:
29.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QMS_A_1N1A401_1
(SERINE/THREONINE-PRO
TEIN KINASE 24)		 4e93 TYROSINE-PROTEIN
KINASE FES/FPS
(Homo
sapiens) 		6 / 11 ILE A 567
ALA A 588
ILE A 634
MET A 636
LEU A 690
ASP A 701
 GUI  A 901 (-4.0A)
GUI  A 901 (-3.4A)
None
GUI  A 901 ( 4.8A)
GUI  A 901 (-4.3A)
GUI  A 901 ( 4.1A)
 0.60A 4qmsA-4e93A:
21.6		 4qmsA-4e93A:
25.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QMS_A_1N1A401_1
(SERINE/THREONINE-PRO
TEIN KINASE 24)		 5jzn SERINE/THREONINE-PRO
TEIN KINASE DCLK1
(Homo
sapiens) 		6 / 11 ILE A 396
ALA A 417
GLU A 436
MET A 465
LEU A 518
ASP A 533
 GUI  A 701 (-4.1A)
GUI  A 701 ( 3.9A)
None
GUI  A 701 ( 4.1A)
GUI  A 701 (-4.4A)
GUI  A 701 ( 4.8A)
 0.74A 4qmsA-5jznA:
29.4		 4qmsA-5jznA:
29.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QMZ_A_B49A401_1
(SERINE/THREONINE-PRO
TEIN KINASE 24)		 4e93 TYROSINE-PROTEIN
KINASE FES/FPS
(Homo
sapiens) 		6 / 12 ILE A 567
GLY A 568
VAL A 575
ALA A 588
MET A 636
LEU A 690
 GUI  A 901 (-4.0A)
GUI  A 901 ( 4.3A)
GUI  A 901 (-4.5A)
GUI  A 901 (-3.4A)
GUI  A 901 ( 4.8A)
GUI  A 901 (-4.3A)
 0.81A 4qmzA-4e93A:
29.6		 4qmzA-4e93A:
25.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QMZ_A_B49A401_1
(SERINE/THREONINE-PRO
TEIN KINASE 24)		 5jzn SERINE/THREONINE-PRO
TEIN KINASE DCLK1
(Homo
sapiens) 		6 / 12 ILE A 396
GLY A 397
VAL A 404
ALA A 417
MET A 465
LEU A 518
 GUI  A 701 (-4.1A)
GUI  A 701 ( 3.8A)
GUI  A 701 (-4.4A)
GUI  A 701 ( 3.9A)
GUI  A 701 ( 4.1A)
GUI  A 701 (-4.4A)
 0.44A 4qmzA-5jznA:
29.0		 4qmzA-5jznA:
29.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QRC_A_0LIA802_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 4e93 TYROSINE-PROTEIN
KINASE FES/FPS
(Homo
sapiens) 		5 / 12 ALA A 588
GLU A 607
LEU A 674
CYH A 679
ARG A 682
 GUI  A 901 (-3.4A)
None
None
None
None
 1.08A 4qrcA-4e93A:
32.2		 4qrcA-4e93A:
33.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZ7_A_1E8A901_1
(CGMP-DEPENDENT
PROTEIN KINASE,
PUTATIVE)		 4e93 TYROSINE-PROTEIN
KINASE FES/FPS
(Homo
sapiens) 		5 / 10 ILE A 567
ALA A 588
LEU A 638
VAL A 639
LEU A 690
 GUI  A 901 (-4.0A)
GUI  A 901 (-3.4A)
GUI  A 901 (-4.4A)
GUI  A 901 (-4.0A)
GUI  A 901 (-4.3A)
 0.68A 4rz7A-4e93A:
18.2		 4rz7A-4e93A:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZ7_A_1E8A901_1
(CGMP-DEPENDENT
PROTEIN KINASE,
PUTATIVE)		 5jzn SERINE/THREONINE-PRO
TEIN KINASE DCLK1
(Homo
sapiens) 		5 / 10 ILE A 396
ALA A 417
LEU A 467
VAL A 468
LEU A 518
 GUI  A 701 (-4.1A)
GUI  A 701 ( 3.9A)
GUI  A 701 ( 4.7A)
GUI  A 701 (-4.0A)
GUI  A 701 (-4.4A)
 0.57A 4rz7A-5jznA:
11.8		 4rz7A-5jznA:
17.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4U0I_A_0LIA1001_2
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR
KIT,MAST/STEM CELL
GROWTH FACTOR
RECEPTOR KIT)		 4e93 TYROSINE-PROTEIN
KINASE FES/FPS
(Homo
sapiens) 		6 / 12 ALA A 588
LEU A 611
GLY A 642
CYH A 679
HIS A 681
LEU A 690
 GUI  A 901 (-3.4A)
None
GUI  A 901 (-3.5A)
None
None
GUI  A 901 (-4.3A)
 0.40A 4u0iA-4e93A:
32.8		 4u0iA-4e93A:
31.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4UXQ_A_0LIA1752_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 4e93 TYROSINE-PROTEIN
KINASE FES/FPS
(Homo
sapiens) 		5 / 12 ALA A 588
LEU A 674
CYH A 679
HIS A 681
LEU A 690
 GUI  A 901 (-3.4A)
None
None
None
GUI  A 901 (-4.3A)
 0.37A 4uxqA-4e93A:
32.6		 4uxqA-4e93A:
32.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4V04_A_0LIA1772_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 4e93 TYROSINE-PROTEIN
KINASE FES/FPS
(Homo
sapiens) 		6 / 12 VAL A 575
ALA A 588
GLU A 607
LEU A 674
CYH A 679
HIS A 681
 GUI  A 901 (-4.5A)
GUI  A 901 (-3.4A)
None
None
None
None
 1.01A 4v04A-4e93A:
32.1		 4v04A-4e93A:
33.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WBO_C_ANWC601_0
(RHODOPSIN KINASE)		 5jzn SERINE/THREONINE-PRO
TEIN KINASE DCLK1
(Homo
sapiens) 		4 / 6 ARG A 394
ALA A 417
MET A 465
LEU A 518
 None
GUI  A 701 ( 3.9A)
GUI  A 701 ( 4.1A)
GUI  A 701 (-4.4A)
 0.51A 4wboC-5jznA:
26.0		 4wboC-5jznA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WKQ_A_IREA1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 5jzn SERINE/THREONINE-PRO
TEIN KINASE DCLK1
(Homo
sapiens) 		7 / 12 ALA A 417
GLU A 436
LEU A 463
LEU A 467
GLY A 471
ASP A 475
LEU A 518
 GUI  A 701 ( 3.9A)
None
None
GUI  A 701 ( 4.7A)
GUI  A 701 (-3.6A)
GUI  A 701 (-4.1A)
GUI  A 701 (-4.4A)
 0.56A 4wkqA-5jznA:
24.5		 4wkqA-5jznA:
25.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WKQ_A_IREA1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 5jzn SERINE/THREONINE-PRO
TEIN KINASE DCLK1
(Homo
sapiens) 		7 / 12 ALA A 417
LYS A 419
GLU A 436
LEU A 463
GLY A 471
ASP A 475
LEU A 518
 GUI  A 701 ( 3.9A)
GUI  A 701 (-3.1A)
None
None
GUI  A 701 (-3.6A)
GUI  A 701 (-4.1A)
GUI  A 701 (-4.4A)
 0.71A 4wkqA-5jznA:
24.5		 4wkqA-5jznA:
25.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XEY_A_1N1A601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4e93 TYROSINE-PROTEIN
KINASE FES/FPS
(Homo
sapiens) 		7 / 12 VAL A 575
ALA A 588
LYS A 590
VAL A 620
ILE A 634
GLY A 642
LEU A 690
 GUI  A 901 (-4.5A)
GUI  A 901 (-3.4A)
GUI  A 901 (-2.8A)
None
None
GUI  A 901 (-3.5A)
GUI  A 901 (-4.3A)
 0.72A 4xeyA-4e93A:
34.7		 4xeyA-4e93A:
38.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XV2_A_P06A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 5jzn SERINE/THREONINE-PRO
TEIN KINASE DCLK1
(Homo
sapiens) 		6 / 12 VAL A 404
ALA A 417
LYS A 419
GLY A 532
ASP A 533
PHE A 534
 GUI  A 701 (-4.4A)
GUI  A 701 ( 3.9A)
GUI  A 701 (-3.1A)
GUI  A 701 ( 4.7A)
GUI  A 701 ( 4.8A)
None
 0.90A 4xv2A-5jznA:
23.5		 4xv2A-5jznA:
26.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XV2_B_P06B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 4e93 TYROSINE-PROTEIN
KINASE FES/FPS
(Homo
sapiens) 		5 / 12 ALA A 588
LYS A 590
LEU A 611
ASP A 701
PHE A 702
 GUI  A 901 (-3.4A)
GUI  A 901 (-2.8A)
None
GUI  A 901 ( 4.1A)
None
 0.96A 4xv2B-4e93A:
29.5		 4xv2B-4e93A:
26.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XV2_B_P06B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 5jzn SERINE/THREONINE-PRO
TEIN KINASE DCLK1
(Homo
sapiens) 		5 / 12 ALA A 417
LYS A 419
GLY A 532
ASP A 533
PHE A 534
 GUI  A 701 ( 3.9A)
GUI  A 701 (-3.1A)
GUI  A 701 ( 4.7A)
GUI  A 701 ( 4.8A)
None
 0.80A 4xv2B-5jznA:
23.5		 4xv2B-5jznA:
26.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XV2_B_P06B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 5jzn SERINE/THREONINE-PRO
TEIN KINASE DCLK1
(Homo
sapiens) 		5 / 12 ALA A 417
LYS A 419
LEU A 440
GLY A 532
PHE A 534
 GUI  A 701 ( 3.9A)
GUI  A 701 (-3.1A)
None
GUI  A 701 ( 4.7A)
None
 0.79A 4xv2B-5jznA:
23.5		 4xv2B-5jznA:
26.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z2E_F_TR6F101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
SYMMETRIZED E-SITE
DNA)		 4e93 TYROSINE-PROTEIN
KINASE FES/FPS
(Homo
sapiens) 		4 / 5 GLY A 570
ARG A 569
GLY A 568
GLU A 574
 GUI  A 901 (-3.4A)
None
GUI  A 901 ( 4.3A)
None
 1.27A 4z2eB-4e93A:
undetectable
4z2eC-4e93A:
undetectable		 4z2eB-4e93A:
21.98
4z2eC-4e93A:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AAA_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 5jzn SERINE/THREONINE-PRO
TEIN KINASE DCLK1
(Homo
sapiens) 		6 / 9 VAL A 404
ALA A 417
GLY A 471
LEU A 518
GLY A 532
ASP A 533
 GUI  A 701 (-4.4A)
GUI  A 701 ( 3.9A)
GUI  A 701 (-3.6A)
GUI  A 701 (-4.4A)
GUI  A 701 ( 4.7A)
GUI  A 701 ( 4.8A)
 0.66A 5aaaA-5jznA:
23.2		 5aaaA-5jznA:
25.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSW_A_P06A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 5jzn SERINE/THREONINE-PRO
TEIN KINASE DCLK1
(Homo
sapiens) 		6 / 12 VAL A 404
ALA A 417
LYS A 419
LEU A 440
GLY A 532
PHE A 534
 GUI  A 701 (-4.4A)
GUI  A 701 ( 3.9A)
GUI  A 701 (-3.1A)
None
GUI  A 701 ( 4.7A)
None
 0.84A 5cswA-5jznA:
23.3		 5cswA-5jznA:
27.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSW_B_P06B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 5jzn SERINE/THREONINE-PRO
TEIN KINASE DCLK1
(Homo
sapiens) 		6 / 12 VAL A 404
ALA A 417
LYS A 419
LEU A 440
GLY A 532
PHE A 534
 GUI  A 701 (-4.4A)
GUI  A 701 ( 3.9A)
GUI  A 701 (-3.1A)
None
GUI  A 701 ( 4.7A)
None
 0.81A 5cswB-5jznA:
23.4		 5cswB-5jznA:
27.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5H2U_A_1N1A501_1
(PROTEIN-TYROSINE
KINASE 6)		 4e93 TYROSINE-PROTEIN
KINASE FES/FPS
(Homo
sapiens) 		6 / 12 VAL A 575
ALA A 588
LYS A 590
LEU A 638
GLY A 642
LEU A 690
 GUI  A 901 (-4.5A)
GUI  A 901 (-3.4A)
GUI  A 901 (-2.8A)
GUI  A 901 (-4.4A)
GUI  A 901 (-3.5A)
GUI  A 901 (-4.3A)
 0.75A 5h2uA-4e93A:
32.1		 5h2uA-4e93A:
33.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5H2U_B_1N1B501_1
(PROTEIN-TYROSINE
KINASE 6)		 4e93 TYROSINE-PROTEIN
KINASE FES/FPS
(Homo
sapiens) 		8 / 12 VAL A 575
ALA A 588
LYS A 590
ILE A 634
LEU A 638
GLY A 642
LEU A 690
ASP A 701
 GUI  A 901 (-4.5A)
GUI  A 901 (-3.4A)
GUI  A 901 (-2.8A)
None
GUI  A 901 (-4.4A)
GUI  A 901 (-3.5A)
GUI  A 901 (-4.3A)
GUI  A 901 ( 4.1A)
 0.90A 5h2uB-4e93A:
32.4		 5h2uB-4e93A:
33.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H2U_C_1N1C501_1
(PROTEIN-TYROSINE
KINASE 6)		 5jzn SERINE/THREONINE-PRO
TEIN KINASE DCLK1
(Homo
sapiens) 		6 / 12 ARG A 394
ALA A 417
LYS A 419
GLY A 471
LEU A 518
GLY A 532
 None
GUI  A 701 ( 3.9A)
GUI  A 701 (-3.1A)
GUI  A 701 (-3.6A)
GUI  A 701 (-4.4A)
GUI  A 701 ( 4.7A)
 0.84A 5h2uC-5jznA:
22.5		 5h2uC-5jznA:
26.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5H2U_D_1N1D504_1
(PROTEIN-TYROSINE
KINASE 6)		 4e93 TYROSINE-PROTEIN
KINASE FES/FPS
(Homo
sapiens) 		6 / 12 VAL A 575
ALA A 588
ILE A 634
LEU A 638
GLY A 642
LEU A 690
 GUI  A 901 (-4.5A)
GUI  A 901 (-3.4A)
None
GUI  A 901 (-4.4A)
GUI  A 901 (-3.5A)
GUI  A 901 (-4.3A)
 0.51A 5h2uD-4e93A:
26.2		 5h2uD-4e93A:
33.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5H2U_D_1N1D504_1
(PROTEIN-TYROSINE
KINASE 6)		 4e93 TYROSINE-PROTEIN
KINASE FES/FPS
(Homo
sapiens) 		6 / 12 VAL A 575
ALA A 588
LEU A 638
GLY A 642
LEU A 690
ASP A 701
 GUI  A 901 (-4.5A)
GUI  A 901 (-3.4A)
GUI  A 901 (-4.4A)
GUI  A 901 (-3.5A)
GUI  A 901 (-4.3A)
GUI  A 901 ( 4.1A)
 0.60A 5h2uD-4e93A:
26.2		 5h2uD-4e93A:
33.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H2U_D_1N1D504_1
(PROTEIN-TYROSINE
KINASE 6)		 5jzn SERINE/THREONINE-PRO
TEIN KINASE DCLK1
(Homo
sapiens) 		6 / 12 VAL A 404
ALA A 417
LEU A 467
GLY A 471
LEU A 518
GLY A 532
 GUI  A 701 (-4.4A)
GUI  A 701 ( 3.9A)
GUI  A 701 ( 4.7A)
GUI  A 701 (-3.6A)
GUI  A 701 (-4.4A)
GUI  A 701 ( 4.7A)
 0.60A 5h2uD-5jznA:
22.7		 5h2uD-5jznA:
26.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HI2_A_BAXA801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 5jzn SERINE/THREONINE-PRO
TEIN KINASE DCLK1
(Homo
sapiens) 		6 / 12 ALA A 417
GLU A 436
LEU A 440
LEU A 502
HIS A 509
GLY A 532
 GUI  A 701 ( 3.9A)
None
None
None
None
GUI  A 701 ( 4.7A)
 0.85A 5hi2A-5jznA:
23.9		 5hi2A-5jznA:
27.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5I9X_A_DB8A1001_1
(EPHRIN TYPE-A
RECEPTOR 2)		 4e93 TYROSINE-PROTEIN
KINASE FES/FPS
(Homo
sapiens) 		7 / 12 ILE A 567
ALA A 588
GLU A 607
ILE A 634
GLY A 642
LEU A 690
SER A 700
 GUI  A 901 (-4.0A)
GUI  A 901 (-3.4A)
None
None
GUI  A 901 (-3.5A)
GUI  A 901 (-4.3A)
GUI  A 901 (-3.1A)
 0.58A 5i9xA-4e93A:
34.6		 5i9xA-4e93A:
34.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5I9Y_A_1N1A1001_1
(EPHRIN TYPE-A
RECEPTOR 2)		 4e93 TYROSINE-PROTEIN
KINASE FES/FPS
(Homo
sapiens) 		7 / 12 ILE A 567
ALA A 588
LYS A 590
GLU A 607
GLY A 642
LEU A 690
SER A 700
 GUI  A 901 (-4.0A)
GUI  A 901 (-3.4A)
GUI  A 901 (-2.8A)
None
GUI  A 901 (-3.5A)
GUI  A 901 (-4.3A)
GUI  A 901 (-3.1A)
 0.59A 5i9yA-4e93A:
34.4		 5i9yA-4e93A:
34.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2I_A_LQQA900_1
(CYCLIN-DEPENDENT
KINASE 6)		 4e93 TYROSINE-PROTEIN
KINASE FES/FPS
(Homo
sapiens) 		6 / 12 ALA A 588
VAL A 620
ASP A 643
THR A 646
LEU A 690
ASP A 701
 GUI  A 901 (-3.4A)
None
GUI  A 901 ( 4.8A)
GUI  A 901 ( 3.8A)
GUI  A 901 (-4.3A)
GUI  A 901 ( 4.1A)
 0.65A 5l2iA-4e93A:
7.6		 5l2iA-4e93A:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2I_A_LQQA900_1
(CYCLIN-DEPENDENT
KINASE 6)		 4e93 TYROSINE-PROTEIN
KINASE FES/FPS
(Homo
sapiens) 		8 / 12 ILE A 567
GLY A 568
VAL A 575
ALA A 588
VAL A 620
ASP A 643
THR A 646
LEU A 690
 GUI  A 901 (-4.0A)
GUI  A 901 ( 4.3A)
GUI  A 901 (-4.5A)
GUI  A 901 (-3.4A)
None
GUI  A 901 ( 4.8A)
GUI  A 901 ( 3.8A)
GUI  A 901 (-4.3A)
 1.03A 5l2iA-4e93A:
7.6		 5l2iA-4e93A:
22.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5L2I_A_LQQA900_1
(CYCLIN-DEPENDENT
KINASE 6)		 5jzn SERINE/THREONINE-PRO
TEIN KINASE DCLK1
(Homo
sapiens) 		6 / 12 GLY A 397
VAL A 404
ALA A 417
VAL A 449
ASP A 472
LEU A 518
 GUI  A 701 ( 3.8A)
GUI  A 701 (-4.4A)
GUI  A 701 ( 3.9A)
None
None
GUI  A 701 (-4.4A)
 0.63A 5l2iA-5jznA:
7.9		 5l2iA-5jznA:
31.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2T_A_6ZZA900_1
(CYCLIN-DEPENDENT
KINASE 6)		 4e93 TYROSINE-PROTEIN
KINASE FES/FPS
(Homo
sapiens) 		6 / 12 ALA A 588
VAL A 620
ASP A 643
THR A 646
LEU A 690
ASP A 701
 GUI  A 901 (-3.4A)
None
GUI  A 901 ( 4.8A)
GUI  A 901 ( 3.8A)
GUI  A 901 (-4.3A)
GUI  A 901 ( 4.1A)
 0.86A 5l2tA-4e93A:
7.7		 5l2tA-4e93A:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2T_A_6ZZA900_1
(CYCLIN-DEPENDENT
KINASE 6)		 4e93 TYROSINE-PROTEIN
KINASE FES/FPS
(Homo
sapiens) 		7 / 12 ILE A 567
GLY A 568
ALA A 588
VAL A 620
ASP A 643
THR A 646
LEU A 690
 GUI  A 901 (-4.0A)
GUI  A 901 ( 4.3A)
GUI  A 901 (-3.4A)
None
GUI  A 901 ( 4.8A)
GUI  A 901 ( 3.8A)
GUI  A 901 (-4.3A)
 1.01A 5l2tA-4e93A:
7.7		 5l2tA-4e93A:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2T_A_6ZZA900_1
(CYCLIN-DEPENDENT
KINASE 6)		 4e93 TYROSINE-PROTEIN
KINASE FES/FPS
(Homo
sapiens) 		7 / 12 ILE A 567
GLY A 568
VAL A 575
ALA A 588
VAL A 620
ASP A 643
LEU A 690
 GUI  A 901 (-4.0A)
GUI  A 901 ( 4.3A)
GUI  A 901 (-4.5A)
GUI  A 901 (-3.4A)
None
GUI  A 901 ( 4.8A)
GUI  A 901 (-4.3A)
 1.01A 5l2tA-4e93A:
7.7		 5l2tA-4e93A:
22.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5L2T_A_6ZZA900_1
(CYCLIN-DEPENDENT
KINASE 6)		 5jzn SERINE/THREONINE-PRO
TEIN KINASE DCLK1
(Homo
sapiens) 		7 / 12 ILE A 396
GLY A 397
VAL A 404
ALA A 417
VAL A 449
ASP A 472
LEU A 518
 GUI  A 701 (-4.1A)
GUI  A 701 ( 3.8A)
GUI  A 701 (-4.4A)
GUI  A 701 ( 3.9A)
None
None
GUI  A 701 (-4.4A)
 1.14A 5l2tA-5jznA:
8.0		 5l2tA-5jznA:
31.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LW1_H_ADNH401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 8)		 5jzn SERINE/THREONINE-PRO
TEIN KINASE DCLK1
(Homo
sapiens) 		5 / 9 GLY A 397
VAL A 404
ALA A 417
MET A 465
LEU A 467
 GUI  A 701 ( 3.8A)
GUI  A 701 (-4.4A)
GUI  A 701 ( 3.9A)
GUI  A 701 ( 4.1A)
GUI  A 701 ( 4.7A)
 0.66A 5lw1H-5jznA:
19.6		 5lw1H-5jznA:
14.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MAF_A_XINA403_1
(MATERNAL EMBRYONIC
LEUCINE ZIPPER
KINASE)		 4e93 TYROSINE-PROTEIN
KINASE FES/FPS
(Homo
sapiens) 		7 / 12 ILE A 567
GLY A 568
VAL A 575
ALA A 588
LYS A 590
GLU A 607
GLY A 642
 GUI  A 901 (-4.0A)
GUI  A 901 ( 4.3A)
GUI  A 901 (-4.5A)
GUI  A 901 (-3.4A)
GUI  A 901 (-2.8A)
None
GUI  A 901 (-3.5A)
 0.80A 5mafA-4e93A:
27.0		 5mafA-4e93A:
13.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5N3H_A_NCAA401_0
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA)		 5jzn SERINE/THREONINE-PRO
TEIN KINASE DCLK1
(Homo
sapiens) 		6 / 10 VAL A 404
ALA A 417
VAL A 449
MET A 465
VAL A 468
LEU A 518
 GUI  A 701 (-4.4A)
GUI  A 701 ( 3.9A)
None
GUI  A 701 ( 4.1A)
GUI  A 701 (-4.0A)
GUI  A 701 (-4.4A)
 0.55A 5n3hA-5jznA:
29.3		 5n3hA-5jznA:
35.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5P9I_A_1E8A701_1
(TYROSINE-PROTEIN
KINASE BTK)		 4e93 TYROSINE-PROTEIN
KINASE FES/FPS
(Homo
sapiens) 		6 / 12 GLY A 570
VAL A 575
ALA A 588
LYS A 590
ILE A 634
LEU A 690
 GUI  A 901 (-3.4A)
GUI  A 901 (-4.5A)
GUI  A 901 (-3.4A)
GUI  A 901 (-2.8A)
None
GUI  A 901 (-4.3A)
 0.78A 5p9iA-4e93A:
33.4		 5p9iA-4e93A:
34.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5P9I_A_1E8A701_1
(TYROSINE-PROTEIN
KINASE BTK)		 4e93 TYROSINE-PROTEIN
KINASE FES/FPS
(Homo
sapiens) 		7 / 12 GLY A 570
VAL A 575
ALA A 588
LYS A 590
LEU A 690
SER A 700
PHE A 702
 GUI  A 901 (-3.4A)
GUI  A 901 (-4.5A)
GUI  A 901 (-3.4A)
GUI  A 901 (-2.8A)
GUI  A 901 (-4.3A)
GUI  A 901 (-3.1A)
None
 1.36A 5p9iA-4e93A:
33.4		 5p9iA-4e93A:
34.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5P9I_A_1E8A701_1
(TYROSINE-PROTEIN
KINASE BTK)		 4e93 TYROSINE-PROTEIN
KINASE FES/FPS
(Homo
sapiens) 		7 / 12 VAL A 575
ALA A 588
LYS A 590
GLY A 642
LEU A 690
SER A 700
PHE A 702
 GUI  A 901 (-4.5A)
GUI  A 901 (-3.4A)
GUI  A 901 (-2.8A)
GUI  A 901 (-3.5A)
GUI  A 901 (-4.3A)
GUI  A 901 (-3.1A)
None
 1.23A 5p9iA-4e93A:
33.4		 5p9iA-4e93A:
34.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5P9I_A_1E8A701_1
(TYROSINE-PROTEIN
KINASE BTK)		 4e93 TYROSINE-PROTEIN
KINASE FES/FPS
(Homo
sapiens) 		6 / 12 VAL A 575
ALA A 588
LYS A 590
ILE A 634
GLY A 642
LEU A 690
 GUI  A 901 (-4.5A)
GUI  A 901 (-3.4A)
GUI  A 901 (-2.8A)
None
GUI  A 901 (-3.5A)
GUI  A 901 (-4.3A)
 0.74A 5p9iA-4e93A:
33.4		 5p9iA-4e93A:
34.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U63_A_ACTA406_0
(THIOREDOXIN
REDUCTASE)		 4e93 TYROSINE-PROTEIN
KINASE FES/FPS
(Homo
sapiens) 		3 / 3 HIS A 681
SER A 700
ARG A 687
 None
GUI  A 901 (-3.1A)
None
 0.99A 5u63A-4e93A:
undetectable		 5u63A-4e93A:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VC3_A_DB8A601_1
(WEE1-LIKE PROTEIN
KINASE)		 5jzn SERINE/THREONINE-PRO
TEIN KINASE DCLK1
(Homo
sapiens) 		6 / 12 ILE A 396
GLY A 397
ALA A 417
GLU A 436
GLY A 471
ASP A 533
 GUI  A 701 (-4.1A)
GUI  A 701 ( 3.8A)
GUI  A 701 ( 3.9A)
None
GUI  A 701 (-3.6A)
GUI  A 701 ( 4.8A)
 0.83A 5vc3A-5jznA:
28.1		 5vc3A-5jznA:
28.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCV_A_1N1A404_1
(MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE)		 5jzn SERINE/THREONINE-PRO
TEIN KINASE DCLK1
(Homo
sapiens) 		6 / 12 ALA A 417
GLU A 436
VAL A 449
LEU A 463
GLY A 471
GLY A 532
 GUI  A 701 ( 3.9A)
None
None
None
GUI  A 701 (-3.6A)
GUI  A 701 ( 4.7A)
 1.07A 5vcvA-5jznA:
23.5		 5vcvA-5jznA:
25.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCY_A_DB8A401_2
(MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE)		 4e93 TYROSINE-PROTEIN
KINASE FES/FPS
(Homo
sapiens) 		4 / 4 VAL A 620
LEU A 638
ASN A 688
ASP A 701
 None
GUI  A 901 (-4.4A)
GUI  A 901 (-4.6A)
GUI  A 901 ( 4.1A)
 0.84A 5vcyA-4e93A:
25.0		 5vcyA-4e93A:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCY_A_DB8A401_2
(MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE)		 5jzn SERINE/THREONINE-PRO
TEIN KINASE DCLK1
(Homo
sapiens) 		4 / 4 VAL A 449
LEU A 467
ASN A 516
ASP A 533
 None
GUI  A 701 ( 4.7A)
GUI  A 701 (-4.4A)
GUI  A 701 ( 4.8A)
 0.84A 5vcyA-5jznA:
27.5		 5vcyA-5jznA:
25.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7Z_A_IREA401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 5jzn SERINE/THREONINE-PRO
TEIN KINASE DCLK1
(Homo
sapiens) 		7 / 12 ARG A 394
VAL A 404
ALA A 417
GLU A 436
LEU A 467
GLY A 471
LEU A 518
 None
GUI  A 701 (-4.4A)
GUI  A 701 ( 3.9A)
None
GUI  A 701 ( 4.7A)
GUI  A 701 (-3.6A)
GUI  A 701 (-4.4A)
 0.68A 5y7zA-5jznA:
26.1		 5y7zA-5jznA:
14.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5Y7Z_A_IREA401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 5jzn SERINE/THREONINE-PRO
TEIN KINASE DCLK1
(Homo
sapiens) 		7 / 12 ARG A 394
VAL A 404
ALA A 417
GLU A 436
LEU A 467
GLY A 471
LEU A 518
 None
GUI  A 701 (-4.4A)
GUI  A 701 ( 3.9A)
None
GUI  A 701 ( 4.7A)
GUI  A 701 (-3.6A)
GUI  A 701 (-4.4A)
 0.68A 5y7zA-5jznA:
26.1		 5y7zA-5jznA:
32.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7Z_B_IREB401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 5jzn SERINE/THREONINE-PRO
TEIN KINASE DCLK1
(Homo
sapiens) 		7 / 12 ALA A 417
GLU A 436
LEU A 463
LEU A 467
GLY A 471
LEU A 518
ASP A 533
 GUI  A 701 ( 3.9A)
None
None
GUI  A 701 ( 4.7A)
GUI  A 701 (-3.6A)
GUI  A 701 (-4.4A)
GUI  A 701 ( 4.8A)
 0.70A 5y7zB-5jznA:
26.1		 5y7zB-5jznA:
14.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y80_A_IREA401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 5jzn SERINE/THREONINE-PRO
TEIN KINASE DCLK1
(Homo
sapiens) 		7 / 12 VAL A 404
ALA A 417
GLU A 436
LEU A 467
GLY A 471
LEU A 518
ASP A 533
 GUI  A 701 (-4.4A)
GUI  A 701 ( 3.9A)
None
GUI  A 701 ( 4.7A)
GUI  A 701 (-3.6A)
GUI  A 701 (-4.4A)
GUI  A 701 ( 4.8A)
 0.58A 5y80A-5jznA:
25.1		 5y80A-5jznA:
14.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YU9_B_1E8B1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 5jzn SERINE/THREONINE-PRO
TEIN KINASE DCLK1
(Homo
sapiens) 		6 / 12 GLY A 397
VAL A 404
ALA A 417
LEU A 463
ASP A 475
LEU A 518
 GUI  A 701 ( 3.8A)
GUI  A 701 (-4.4A)
GUI  A 701 ( 3.9A)
None
GUI  A 701 (-4.1A)
GUI  A 701 (-4.4A)
 0.61A 5yu9B-5jznA:
22.4		 5yu9B-5jznA:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YU9_C_1E8C1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 5jzn SERINE/THREONINE-PRO
TEIN KINASE DCLK1
(Homo
sapiens) 		5 / 12 VAL A 404
ALA A 417
LEU A 463
GLY A 471
ASP A 475
 GUI  A 701 (-4.4A)
GUI  A 701 ( 3.9A)
None
GUI  A 701 (-3.6A)
GUI  A 701 (-4.1A)
 0.53A 5yu9C-5jznA:
21.9		 5yu9C-5jznA:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YU9_C_1E8C1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 5jzn SERINE/THREONINE-PRO
TEIN KINASE DCLK1
(Homo
sapiens) 		5 / 12 VAL A 404
ALA A 417
LYS A 419
LEU A 463
GLY A 471
 GUI  A 701 (-4.4A)
GUI  A 701 ( 3.9A)
GUI  A 701 (-3.1A)
None
GUI  A 701 (-3.6A)
 0.73A 5yu9C-5jznA:
21.9		 5yu9C-5jznA:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YU9_D_1E8D1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4e93 TYROSINE-PROTEIN
KINASE FES/FPS
(Homo
sapiens) 		6 / 12 VAL A 575
ALA A 588
LYS A 590
GLY A 642
LEU A 690
ASP A 701
 GUI  A 901 (-4.5A)
GUI  A 901 (-3.4A)
GUI  A 901 (-2.8A)
GUI  A 901 (-3.5A)
GUI  A 901 (-4.3A)
GUI  A 901 ( 4.1A)
 1.01A 5yu9D-4e93A:
30.6		 5yu9D-4e93A:
13.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6FNM_A_1N1A1001_1
(-)		 4e93 TYROSINE-PROTEIN
KINASE FES/FPS
(Homo
sapiens) 		9 / 12 ILE A 567
VAL A 575
ALA A 588
LYS A 590
GLU A 607
ILE A 634
GLY A 642
LEU A 690
SER A 700
 GUI  A 901 (-4.0A)
GUI  A 901 (-4.5A)
GUI  A 901 (-3.4A)
GUI  A 901 (-2.8A)
None
None
GUI  A 901 (-3.5A)
GUI  A 901 (-4.3A)
GUI  A 901 (-3.1A)
 0.76A 6fnmA-4e93A:
35.7		 6fnmA-4e93A:
32.48