SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'GTX'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OTF_A_2TNA201_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 3g7j GLUTATHIONE
TRANSFERASE GST1-4
(Anopheles
dirus) 		4 / 5 LEU A  30
ILE A  52
SER A   9
GLY A   8
 None
GTX  A 220 (-4.2A)
GTX  A 220 (-3.2A)
GTX  A 220 (-3.7A)
 0.95A 2otfA-3g7jA:
undetectable		 2otfA-3g7jA:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XRL_A_DXTA1211_1
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		 1pn9 GLUTATHIONE
S-TRANSFERASE 1-6
(Anopheles
gambiae) 		5 / 12 SER A 158
PRO A  53
VAL A  15
GLN A  69
LEU A  72
 None
GTX  A 301 (-4.4A)
None
None
None
 1.38A 2xrlA-1pn9A:
0.2		 2xrlA-1pn9A:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XRL_A_DXTA1211_1
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		 3g7j GLUTATHIONE
TRANSFERASE GST1-4
(Anopheles
dirus) 		5 / 12 SER A 167
PRO A  53
VAL A  15
GLN A  70
LEU A  73
 None
GTX  A 220 (-4.3A)
None
None
None
 1.39A 2xrlA-3g7jA:
undetectable		 2xrlA-3g7jA:
24.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A50_D_VD3D2001_1
(VITAMIN D
HYDROXYLASE)		 1gnw GLUTATHIONE
S-TRANSFERASE
(Arabidopsis
thaliana) 		5 / 12 PRO A  55
LEU A  21
ILE A  74
ALA A  75
LEU A 170
 GTX  A 212 (-4.6A)
None
None
None
None
 1.10A 3a50D-1gnwA:
2.6		 3a50D-1gnwA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BPX_A_SALA257_1
(TRANSCRIPTIONAL
REGULATOR)		 3g7j GLUTATHIONE
TRANSFERASE GST1-4
(Anopheles
dirus) 		4 / 8 SER A  66
ARG A  67
ALA A  10
THR A 174
 GTX  A 220 (-2.6A)
GTX  A 220 (-3.6A)
None
None
 0.96A 3bpxA-3g7jA:
undetectable
3bpxB-3g7jA:
undetectable		 3bpxA-3g7jA:
18.72
3bpxB-3g7jA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_B_ROCB201_4
(HIV-1 PROTEASE)		 1pn9 GLUTATHIONE
S-TRANSFERASE 1-6
(Anopheles
gambiae) 		4 / 4 ARG A  66
ASP A  80
GLY A  77
THR A  18
 GTX  A 301 (-3.6A)
None
None
None
 1.24A 3k4vB-1pn9A:
undetectable		 3k4vB-1pn9A:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TGV_B_BEZB1_0
(HEME-BINDING PROTEIN
HUTZ)		 1pn9 GLUTATHIONE
S-TRANSFERASE 1-6
(Anopheles
gambiae) 		4 / 6 GLN A  69
PHE A   3
PRO A  53
LEU A  55
 None
None
GTX  A 301 (-4.4A)
None
 1.21A 3tgvB-1pn9A:
undetectable		 3tgvB-1pn9A:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TGV_B_BEZB1_0
(HEME-BINDING PROTEIN
HUTZ)		 3g7j GLUTATHIONE
TRANSFERASE GST1-4
(Anopheles
dirus) 		4 / 6 GLN A  70
PHE A   3
PRO A  53
LEU A  55
 None
None
GTX  A 220 (-4.3A)
None
 1.24A 3tgvB-3g7jA:
undetectable		 3tgvB-3g7jA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TGV_D_BEZD1_0
(HEME-BINDING PROTEIN
HUTZ)		 3g7j GLUTATHIONE
TRANSFERASE GST1-4
(Anopheles
dirus) 		4 / 6 GLN A  70
PHE A   3
PRO A  53
LEU A  55
 None
None
GTX  A 220 (-4.3A)
None
 1.23A 3tgvD-3g7jA:
undetectable		 3tgvD-3g7jA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3THR_C_C2FC1410_0
(GLYCINE
N-METHYLTRANSFERASE)		 1gnw GLUTATHIONE
S-TRANSFERASE
(Arabidopsis
thaliana) 		3 / 3 ARG A  48
PRO A  55
PHE A  45
 None
GTX  A 212 (-4.6A)
None
 1.00A 3thrC-1gnwA:
undetectable		 3thrC-1gnwA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VLN_A_ASCA904_0
(GLUTATHIONE
S-TRANSFERASE
OMEGA-1)		 1gnw GLUTATHIONE
S-TRANSFERASE
(Arabidopsis
thaliana) 		4 / 6 ARG A  16
PRO A  55
GLU A  66
SER A  67
 GTX  A 212 ( 4.8A)
GTX  A 212 (-4.6A)
GTX  A 212 (-2.3A)
GTX  A 212 (-2.7A)
 0.94A 3vlnA-1gnwA:
21.1		 3vlnA-1gnwA:
28.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VLN_A_ASCA904_0
(GLUTATHIONE
S-TRANSFERASE
OMEGA-1)		 1gwc GLUTATHIONE
S-TRANSFERASE TSI-1
(Aegilops
tauschii) 		5 / 6 PHE A  17
ARG A  20
PRO A  57
GLU A  68
SER A  69
 GTX  A1225 (-3.8A)
None
GTX  A1225 (-4.1A)
GTX  A1225 (-2.9A)
GTX  A1225 (-2.7A)
 0.47A 3vlnA-1gwcA:
23.9		 3vlnA-1gwcA:
29.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UHX_A_LZUA3008_1
(ALDEHYDE OXIDASE)		 1gnw GLUTATHIONE
S-TRANSFERASE
(Arabidopsis
thaliana) 		4 / 8 HIS A 172
GLU A 106
SER A 115
PRO A 112
 None
None
GTX  A 213 ( 4.0A)
None
 1.19A 4uhxA-1gnwA:
undetectable		 4uhxA-1gnwA:
9.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UHX_A_RTZA3009_1
(ALDEHYDE OXIDASE)		 1gnw GLUTATHIONE
S-TRANSFERASE
(Arabidopsis
thaliana) 		4 / 8 HIS A 172
GLU A 106
SER A 115
PRO A 112
 None
None
GTX  A 213 ( 4.0A)
None
 1.19A 4uhxA-1gnwA:
undetectable		 4uhxA-1gnwA:
9.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJL_A_ERYA1101_0
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 1gwc GLUTATHIONE
S-TRANSFERASE TSI-1
(Aegilops
tauschii) 		5 / 12 SER A  69
SER A 170
PHE A 184
PHE A 199
LEU A  27
 GTX  A1225 (-2.7A)
None
None
None
None
 1.39A 4zjlA-1gwcA:
0.0		 4zjlA-1gwcA:
13.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A4I_B_TRPB403_0
(TRYPTOPHAN
2,3-DIOXYGENASE)		 3g7j GLUTATHIONE
TRANSFERASE GST1-4
(Anopheles
dirus) 		4 / 7 GLU A  65
TRP A  64
THR A  54
PRO A  53
 GTX  A 220 (-3.2A)
None
None
GTX  A 220 (-4.3A)
 1.41A 6a4iB-3g7jA:
3.6		 6a4iB-3g7jA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BKL_G_EU7G101_0
(MATRIX PROTEIN 2)		 3g7j GLUTATHIONE
TRANSFERASE GST1-4
(Anopheles
dirus) 		5 / 9 ALA A 178
ALA A 209
GLY A 213
ALA A  10
GLY A   8
 None
None
None
None
GTX  A 220 (-3.7A)
 1.05A 6bklE-3g7jA:
undetectable
6bklF-3g7jA:
undetectable
6bklG-3g7jA:
undetectable
6bklH-3g7jA:
undetectable		 6bklE-3g7jA:
9.14
6bklF-3g7jA:
9.14
6bklG-3g7jA:
9.14
6bklH-3g7jA:
9.14