SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'GTS'


List of Similar Pattern of Amino Acids


Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
11GS_A_EAAA211_1
(GLUTATHIONE
S-TRANSFERASE)
2gsr CLASS PI GST
GLUTATHIONE
S-TRANSFERASE

(Sus
scrofa)
6 / 7 TYR A   7
PHE A   8
VAL A  10
ARG A  13
TYR A 106
GLY A 203
GTS  A 208 (-4.5A)
GTS  A 208 (-4.7A)
None
GTS  A 208 (-4.0A)
None
None
0.22A 11gsA-2gsrA:
35.4
11gsA-2gsrA:
82.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
11GS_B_EAAB211_1
(GLUTATHIONE
S-TRANSFERASE)
2gsr CLASS PI GST
GLUTATHIONE
S-TRANSFERASE

(Sus
scrofa)
6 / 7 TYR A   7
PHE A   8
GLY A  12
ARG A  13
TYR A 106
GLY A 203
GTS  A 208 (-4.5A)
GTS  A 208 (-4.7A)
None
GTS  A 208 (-4.0A)
None
None
0.20A 11gsB-2gsrA:
35.4
11gsB-2gsrA:
82.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
11GS_B_EAAB211_1
(GLUTATHIONE
S-TRANSFERASE)
2gsr CLASS PI GST
GLUTATHIONE
S-TRANSFERASE

(Sus
scrofa)
4 / 7 TYR A 106
GLY A 203
TYR A   7
GLY A  12
None
None
GTS  A 208 (-4.5A)
None
0.61A 11gsB-2gsrA:
35.4
11gsB-2gsrA:
82.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
13GS_A_SASA211_1
(GLUTATHIONE
S-TRANSFERASE)
2gsr CLASS PI GST
GLUTATHIONE
S-TRANSFERASE

(Sus
scrofa)
8 / 10 TYR A   7
PHE A   8
PRO A   9
VAL A  10
ARG A  13
TYR A 106
PRO A 200
GLY A 203
GTS  A 208 (-4.5A)
GTS  A 208 (-4.7A)
None
None
GTS  A 208 (-4.0A)
None
None
None
0.24A 13gsA-2gsrA:
35.5
13gsA-2gsrA:
82.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
13GS_B_SASB211_1
(GLUTATHIONE
S-TRANSFERASE)
2gsr CLASS PI GST
GLUTATHIONE
S-TRANSFERASE

(Sus
scrofa)
7 / 9 PHE A   8
PRO A   9
VAL A  10
ARG A  13
TYR A 106
PRO A 200
GLY A 203
GTS  A 208 (-4.7A)
None
None
GTS  A 208 (-4.0A)
None
None
None
0.25A 13gsB-2gsrA:
35.6
13gsB-2gsrA:
82.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1GTI_A_CCSA47_0
(GLUTATHIONE
S-TRANSFERASE)
2gsr CLASS PI GST
GLUTATHIONE
S-TRANSFERASE

(Sus
scrofa)
5 / 7 TRP A  38
LEU A  41
LEU A  46
LEU A  50
TYR A  61
GTS  A 208 (-3.9A)
None
None
GTS  A 208 (-4.8A)
None
0.71A 1gtiA-2gsrA:
34.7
1gtiA-2gsrA:
84.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1GTI_B_CCSB47_0
(GLUTATHIONE
S-TRANSFERASE)
2gsr CLASS PI GST
GLUTATHIONE
S-TRANSFERASE

(Sus
scrofa)
4 / 7 TRP A  38
LEU A  46
LEU A  50
TYR A  61
GTS  A 208 (-3.9A)
None
GTS  A 208 (-4.8A)
None
0.38A 1gtiB-2gsrA:
34.9
1gtiB-2gsrA:
84.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1GTI_C_CCSC47_0
(GLUTATHIONE
S-TRANSFERASE)
2gsr CLASS PI GST
GLUTATHIONE
S-TRANSFERASE

(Sus
scrofa)
4 / 6 TRP A  38
LEU A  46
LYS A  52
TYR A  61
GTS  A 208 (-3.9A)
None
None
None
0.56A 1gtiC-2gsrA:
34.6
1gtiC-2gsrA:
84.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1GTI_D_CCSD47_0
(GLUTATHIONE
S-TRANSFERASE)
2gsr CLASS PI GST
GLUTATHIONE
S-TRANSFERASE

(Sus
scrofa)
5 / 7 TRP A  38
LEU A  46
LEU A  50
LYS A  52
TYR A  61
GTS  A 208 (-3.9A)
None
GTS  A 208 (-4.8A)
None
None
0.39A 1gtiD-2gsrA:
34.8
1gtiD-2gsrA:
84.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1GTI_E_CCSE47_0
(GLUTATHIONE
S-TRANSFERASE)
2gsr CLASS PI GST
GLUTATHIONE
S-TRANSFERASE

(Sus
scrofa)
5 / 7 TRP A  38
LEU A  46
LEU A  50
LYS A  52
TYR A  61
GTS  A 208 (-3.9A)
None
GTS  A 208 (-4.8A)
None
None
0.35A 1gtiE-2gsrA:
34.6
1gtiE-2gsrA:
84.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MT1_C_AG2C7004_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)
1a0f GLUTATHIONE
S-TRANSFERASE

(Escherichia
coli)
4 / 6 ALA A  68
LEU A  62
GLU A  65
LEU A   3
None
None
GTS  A 203 (-3.1A)
None
1.00A 1mt1D-1a0fA:
0.0
1mt1E-1a0fA:
undetectable
1mt1D-1a0fA:
19.21
1mt1E-1a0fA:
12.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2GSS_A_EAAA0_1
(GLUTATHIONE
S-TRANSFERASE P1-1)
2gsr CLASS PI GST
GLUTATHIONE
S-TRANSFERASE

(Sus
scrofa)
7 / 8 TYR A   7
PHE A   8
VAL A  10
ARG A  13
TRP A  38
TYR A 106
GLY A 203
GTS  A 208 (-4.5A)
GTS  A 208 (-4.7A)
None
GTS  A 208 (-4.0A)
GTS  A 208 (-3.9A)
None
None
0.21A 2gssA-2gsrA:
35.6
2gssA-2gsrA:
82.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2GSS_B_EAAB0_1
(GLUTATHIONE
S-TRANSFERASE P1-1)
2gsr CLASS PI GST
GLUTATHIONE
S-TRANSFERASE

(Sus
scrofa)
7 / 8 TYR A   7
PHE A   8
VAL A  10
ARG A  13
TRP A  38
TYR A 106
GLY A 203
GTS  A 208 (-4.5A)
GTS  A 208 (-4.7A)
None
GTS  A 208 (-4.0A)
GTS  A 208 (-3.9A)
None
None
0.21A 2gssB-2gsrA:
35.6
2gssB-2gsrA:
82.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_C_SAMC1003_0
(SAM DEPENDENT
METHYLTRANSFERASE)
1a0f GLUTATHIONE
S-TRANSFERASE

(Escherichia
coli)
5 / 12 HIS A 106
TYR A 157
SER A  14
ALA A  13
ALA A  74
GTS  A 203 (-3.9A)
None
None
None
None
1.19A 2igtC-1a0fA:
undetectable
2igtC-1a0fA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UXP_A_CLMA1211_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TTGR)
1r5a GLUTATHIONE
TRANSFERASE

(Anopheles
cracens)
5 / 8 ALA A  21
LEU A  28
LEU A  30
ILE A 200
ILE A  54
None
None
None
None
GTS  A1004 (-4.0A)
1.24A 2uxpA-1r5aA:
undetectable
2uxpA-1r5aA:
21.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CSJ_B_CBLB211_0
(GLUTATHIONE
S-TRANSFERASE P)
2gsr CLASS PI GST
GLUTATHIONE
S-TRANSFERASE

(Sus
scrofa)
8 / 9 TYR A   7
PHE A   8
PRO A   9
VAL A  10
GLY A  12
ARG A  13
TYR A 106
GLY A 203
GTS  A 208 (-4.5A)
GTS  A 208 (-4.7A)
None
None
None
GTS  A 208 (-4.0A)
None
None
0.27A 3csjB-2gsrA:
35.6
3csjB-2gsrA:
82.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3DGQ_A_EAAA211_1
(GLUTATHIONE
S-TRANSFERASE P)
2gsr CLASS PI GST
GLUTATHIONE
S-TRANSFERASE

(Sus
scrofa)
4 / 5 TYR A   7
ARG A  13
TYR A 106
THR A 107
GTS  A 208 (-4.5A)
GTS  A 208 (-4.0A)
None
None
0.23A 3dgqA-2gsrA:
35.6
3dgqA-2gsrA:
82.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GSS_A_EAAA212_1
(GLUTATHIONE
S-TRANSFERASE P1-1)
2gsr CLASS PI GST
GLUTATHIONE
S-TRANSFERASE

(Sus
scrofa)
5 / 7 PHE A   8
VAL A  10
TYR A 106
THR A 103
GLY A 203
GTS  A 208 (-4.7A)
None
None
None
None
1.20A 3gssA-2gsrA:
35.4
3gssA-2gsrA:
82.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GSS_A_EAAA212_1
(GLUTATHIONE
S-TRANSFERASE P1-1)
2gsr CLASS PI GST
GLUTATHIONE
S-TRANSFERASE

(Sus
scrofa)
6 / 7 TYR A   7
PHE A   8
VAL A  10
TYR A 106
THR A 107
GLY A 203
GTS  A 208 (-4.5A)
GTS  A 208 (-4.7A)
None
None
None
None
0.21A 3gssA-2gsrA:
35.4
3gssA-2gsrA:
82.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GSS_B_EAAB211_1
(GLUTATHIONE
S-TRANSFERASE P1-1)
2gsr CLASS PI GST
GLUTATHIONE
S-TRANSFERASE

(Sus
scrofa)
5 / 7 PHE A   8
VAL A  10
TYR A 106
THR A 103
GLY A 203
GTS  A 208 (-4.7A)
None
None
None
None
1.12A 3gssB-2gsrA:
35.4
3gssB-2gsrA:
82.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GSS_B_EAAB211_1
(GLUTATHIONE
S-TRANSFERASE P1-1)
2gsr CLASS PI GST
GLUTATHIONE
S-TRANSFERASE

(Sus
scrofa)
6 / 7 TYR A   7
PHE A   8
VAL A  10
TYR A 106
THR A 107
GLY A 203
GTS  A 208 (-4.5A)
GTS  A 208 (-4.7A)
None
None
None
None
0.28A 3gssB-2gsrA:
35.4
3gssB-2gsrA:
82.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GSS_B_EAAB211_1
(GLUTATHIONE
S-TRANSFERASE P1-1)
2gsr CLASS PI GST
GLUTATHIONE
S-TRANSFERASE

(Sus
scrofa)
4 / 7 TYR A 106
TYR A   7
THR A   6
GLY A  12
None
GTS  A 208 (-4.5A)
None
None
0.73A 3gssB-2gsrA:
35.4
3gssB-2gsrA:
82.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3HJO_A_EAAA211_1
(GLUTATHIONE
S-TRANSFERASE P)
2gsr CLASS PI GST
GLUTATHIONE
S-TRANSFERASE

(Sus
scrofa)
5 / 8 TYR A   7
PHE A   8
VAL A  10
TRP A  38
GLY A 203
GTS  A 208 (-4.5A)
GTS  A 208 (-4.7A)
None
GTS  A 208 (-3.9A)
None
0.20A 3hjoA-2gsrA:
35.8
3hjoA-2gsrA:
82.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3HJO_B_EAAB211_1
(GLUTATHIONE
S-TRANSFERASE P)
2gsr CLASS PI GST
GLUTATHIONE
S-TRANSFERASE

(Sus
scrofa)
5 / 8 PHE A   8
VAL A  10
TRP A  38
ASN A 202
GLY A 203
GTS  A 208 (-4.7A)
None
GTS  A 208 (-3.9A)
None
None
0.21A 3hjoB-2gsrA:
35.8
3hjoB-2gsrA:
82.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3KM6_A_EAAA222_1
(GLUTATHIONE
S-TRANSFERASE P)
2gsr CLASS PI GST
GLUTATHIONE
S-TRANSFERASE

(Sus
scrofa)
7 / 10 TYR A   7
PHE A   8
VAL A  10
GLY A  12
TRP A  38
ASN A 202
GLY A 203
GTS  A 208 (-4.5A)
GTS  A 208 (-4.7A)
None
None
GTS  A 208 (-3.9A)
None
None
0.17A 3km6A-2gsrA:
35.5
3km6A-2gsrA:
81.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3KM6_B_EAAB222_1
(GLUTATHIONE
S-TRANSFERASE P)
2gsr CLASS PI GST
GLUTATHIONE
S-TRANSFERASE

(Sus
scrofa)
6 / 9 TYR A   7
PHE A   8
VAL A  10
TRP A  38
ASN A 202
GLY A 203
GTS  A 208 (-4.5A)
GTS  A 208 (-4.7A)
None
GTS  A 208 (-3.9A)
None
None
0.21A 3km6B-2gsrA:
35.8
3km6B-2gsrA:
81.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3KMO_A_EAAA214_1
(GLUTATHIONE
S-TRANSFERASE P)
2gsr CLASS PI GST
GLUTATHIONE
S-TRANSFERASE

(Sus
scrofa)
7 / 9 TYR A   7
PHE A   8
VAL A  10
GLY A  12
TRP A  38
ASN A 202
GLY A 203
GTS  A 208 (-4.5A)
GTS  A 208 (-4.7A)
None
None
GTS  A 208 (-3.9A)
None
None
0.27A 3kmoA-2gsrA:
35.3
3kmoA-2gsrA:
81.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3KMO_B_EAAB213_1
(GLUTATHIONE
S-TRANSFERASE P)
2gsr CLASS PI GST
GLUTATHIONE
S-TRANSFERASE

(Sus
scrofa)
6 / 7 TYR A   7
PHE A   8
VAL A  10
TRP A  38
ASN A 202
GLY A 203
GTS  A 208 (-4.5A)
GTS  A 208 (-4.7A)
None
GTS  A 208 (-3.9A)
None
None
0.23A 3kmoB-2gsrA:
35.4
3kmoB-2gsrA:
81.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3N9J_A_EAAA210_1
(GLUTATHIONE
S-TRANSFERASE P)
2gsr CLASS PI GST
GLUTATHIONE
S-TRANSFERASE

(Sus
scrofa)
7 / 8 TYR A   7
PHE A   8
VAL A  10
ARG A  13
TRP A  38
TYR A 106
GLY A 203
GTS  A 208 (-4.5A)
GTS  A 208 (-4.7A)
None
GTS  A 208 (-4.0A)
GTS  A 208 (-3.9A)
None
None
0.27A 3n9jA-2gsrA:
35.6
3n9jA-2gsrA:
82.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3N9J_B_EAAB214_1
(GLUTATHIONE
S-TRANSFERASE P)
2gsr CLASS PI GST
GLUTATHIONE
S-TRANSFERASE

(Sus
scrofa)
7 / 8 TYR A   7
PHE A   8
VAL A  10
GLY A  12
ARG A  13
TYR A 106
GLY A 203
GTS  A 208 (-4.5A)
GTS  A 208 (-4.7A)
None
None
GTS  A 208 (-4.0A)
None
None
0.25A 3n9jB-2gsrA:
35.3
3n9jB-2gsrA:
82.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3N9J_B_EAAB214_1
(GLUTATHIONE
S-TRANSFERASE P)
2gsr CLASS PI GST
GLUTATHIONE
S-TRANSFERASE

(Sus
scrofa)
4 / 8 TYR A 106
GLY A 203
TYR A   7
GLY A  12
None
None
GTS  A 208 (-4.5A)
None
0.65A 3n9jB-2gsrA:
35.3
3n9jB-2gsrA:
82.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TTR_A_LQZA90_1
(LACTOTRANSFERRIN)
1r5a GLUTATHIONE
TRANSFERASE

(Anopheles
cracens)
3 / 3 PRO A  55
THR A  56
LEU A  33
GTS  A1004 (-4.2A)
None
None
0.68A 3ttrA-1r5aA:
undetectable
3ttrA-1r5aA:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A79_A_P1BA601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)
2gsr CLASS PI GST
GLUTATHIONE
S-TRANSFERASE

(Sus
scrofa)
5 / 12 PRO A  51
LEU A  21
ILE A   5
ILE A  66
PHE A  74
GTS  A 208 (-4.3A)
None
None
None
None
1.48A 4a79A-2gsrA:
undetectable
4a79A-2gsrA:
16.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4IJI_H_BEZH501_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN YIBF)
4jed GLUTATHIONE
S-TRANSFERASE

(Methylobacterium
radiotolerans)
4 / 7 SER A  14
VAL A 110
ARG A 174
TYR A 170
GTS  A 302 (-2.5A)
None
None
None
0.93A 4ijiH-4jedA:
23.2
4ijiH-4jedA:
33.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DQF_A_CZEA613_1
(SERUM ALBUMIN)
1r5a GLUTATHIONE
TRANSFERASE

(Anopheles
cracens)
5 / 9 ALA A 160
LEU A 103
LEU A  99
LEU A  71
GLU A  66
None
None
None
None
GTS  A1004 (-2.9A)
1.18A 5dqfA-1r5aA:
3.1
5dqfA-1r5aA:
17.19