SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'GTR'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J7K_A_ACTA701_0
(HOLLIDAY JUNCTION
DNA HELICASE RUVB)		 5ols RHAMNOGALACTURONAN
LYASE
(Bacteroides
thetaiotaomicron) 		4 / 4 GLY A 281
LEU A 318
GLY A 269
ARG A 317
 None
GTR  A 608 (-4.6A)
None
None
 1.02A 1j7kA-5olsA:
undetectable		 1j7kA-5olsA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J7K_A_ACTA701_0
(HOLLIDAY JUNCTION
DNA HELICASE RUVB)		 5ols RHAMNOGALACTURONAN
LYASE
(Bacteroides
thetaiotaomicron) 		4 / 4 GLY A 281
LEU A 318
GLY A 279
ARG A 317
 None
GTR  A 608 (-4.6A)
None
None
 1.03A 1j7kA-5olsA:
undetectable		 1j7kA-5olsA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U1J_A_C2FA773_0
(5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE)		 5ols RHAMNOGALACTURONAN
LYASE
(Bacteroides
thetaiotaomicron) 		4 / 8 ARG A 317
ASN A 339
SER A 340
ARG A 319
 None
None
None
GTR  A 608 (-3.0A)
 1.35A 1u1jA-5olsA:
undetectable		 1u1jA-5olsA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WU8_C_ADNC502_1
(HYPOTHETICAL PROTEIN
PH0463)		 4ovr TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT
(Xanthobacter
autotrophicus) 		4 / 7 PHE A 150
ASN A 208
HIS A 230
VAL A 169
 None
GTR  A 403 (-3.0A)
None
None
 1.25A 1wu8A-4ovrA:
undetectable
1wu8C-4ovrA:
undetectable		 1wu8A-4ovrA:
24.84
1wu8C-4ovrA:
24.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WU8_C_ADNC502_1
(HYPOTHETICAL PROTEIN
PH0463)		 4pf8 TRAP-T FAMILY
TRANSPORTER, DCTP
(PERIPLASMIC
BINDING) SUBUNIT
(Sulfitobacter
sp.
NAS-14.1) 		4 / 7 PHE A 149
ASN A 208
HIS A 230
VAL A 169
 None
GTR  A 402 (-2.9A)
None
None
 1.23A 1wu8A-4pf8A:
undetectable
1wu8C-4pf8A:
undetectable		 1wu8A-4pf8A:
23.50
1wu8C-4pf8A:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DCF_A_ACAA502_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 4pf8 TRAP-T FAMILY
TRANSPORTER, DCTP
(PERIPLASMIC
BINDING) SUBUNIT
(Sulfitobacter
sp.
NAS-14.1) 		5 / 12 ALA A 206
PHE A 191
ASN A 208
GLY A 205
ILE A 198
 None
GTR  A 402 ( 3.7A)
GTR  A 402 (-2.9A)
None
None
 1.33A 2dcfA-4pf8A:
undetectable		 2dcfA-4pf8A:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JC9_A_ADNA1497_1
(CYTOSOLIC PURINE
5'-NUCLEOTIDASE)		 4ovr TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT
(Xanthobacter
autotrophicus) 		4 / 7 ARG A  88
THR A  93
ASN A 208
GLN A  34
 GTR  A 403 (-2.6A)
None
GTR  A 403 (-3.0A)
GTR  A 403 (-4.1A)
 1.00A 2jc9A-4ovrA:
undetectable		 2jc9A-4ovrA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEU_A_ACTA141_0
(PUTATIVE
CARBOXYMUCONOLACTONE
DECARBOXYLASE)		 4n17 TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT
(Burkholderia
ambifaria) 		3 / 3 VAL A  34
ASP A  33
GLU A  73
 None
None
GTR  A 401 ( 2.9A)
 0.74A 2qeuA-4n17A:
undetectable		 2qeuA-4n17A:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEU_A_ACTA141_0
(PUTATIVE
CARBOXYMUCONOLACTONE
DECARBOXYLASE)		 4n8y PUTATIVE TRAP-TYPE
C4-DICARBOXYLATE
TRANSPORT SYSTEM,
BINDING PERIPLASMIC
PROTEIN (DCTP
SUBUNIT)
(Bradyrhizobium
sp.
BTAi1) 		3 / 3 VAL A  30
ASP A  29
GLU A  69
 None
None
GTR  A 402 (-2.9A)
 0.76A 2qeuA-4n8yA:
undetectable		 2qeuA-4n8yA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEU_C_ACTC141_0
(PUTATIVE
CARBOXYMUCONOLACTONE
DECARBOXYLASE)		 4n17 TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT
(Burkholderia
ambifaria) 		3 / 3 VAL A  34
ASP A  33
GLU A  73
 None
None
GTR  A 401 ( 2.9A)
 0.72A 2qeuC-4n17A:
undetectable		 2qeuC-4n17A:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEU_C_ACTC141_0
(PUTATIVE
CARBOXYMUCONOLACTONE
DECARBOXYLASE)		 4n8y PUTATIVE TRAP-TYPE
C4-DICARBOXYLATE
TRANSPORT SYSTEM,
BINDING PERIPLASMIC
PROTEIN (DCTP
SUBUNIT)
(Bradyrhizobium
sp.
BTAi1) 		3 / 3 VAL A  30
ASP A  29
GLU A  69
 None
None
GTR  A 402 (-2.9A)
 0.74A 2qeuC-4n8yA:
undetectable		 2qeuC-4n8yA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VAV_C_CSCC1383_1
(ACETYL-COA--DEACETYL
CEPHALOSPORIN C
ACETYLTRANSFERASE)		 4mij TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT
(Polaromonas
sp.
JS666) 		5 / 12 ARG A 174
TYR A 197
GLN A 177
HIS A  39
VAL A  95
 GTR  A 405 (-3.0A)
GTR  A 405 ( 3.7A)
None
ADA  A 406 ( 4.0A)
None
 1.43A 2vavC-4mijA:
0.0		 2vavC-4mijA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3B_B_FOLB401_1
(DIHYDROFOLATE
REDUCTASE)		 4ovr TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT
(Xanthobacter
autotrophicus) 		3 / 3 GLU A 274
GLN A  34
ARG A  88
 None
GTR  A 403 (-4.1A)
GTR  A 403 (-2.6A)
 0.90A 2w3bB-4ovrA:
undetectable		 2w3bB-4ovrA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XFF_A_QPSA600_1
(BETA-AMYLASE)		 4n17 TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT
(Burkholderia
ambifaria) 		5 / 12 GLU A 236
ARG A  89
GLY A  92
THR A 234
MET A 176
 GTR  A 401 (-2.9A)
GTR  A 401 (-2.7A)
None
None
None
 1.39A 2xffA-4n17A:
undetectable		 2xffA-4n17A:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZMA_A_ACAA502_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 4pf8 TRAP-T FAMILY
TRANSPORTER, DCTP
(PERIPLASMIC
BINDING) SUBUNIT
(Sulfitobacter
sp.
NAS-14.1) 		5 / 11 ALA A 206
PHE A 191
ASN A 208
GLY A 205
ILE A 198
 None
GTR  A 402 ( 3.7A)
GTR  A 402 (-2.9A)
None
None
 1.33A 2zmaA-4pf8A:
undetectable		 2zmaA-4pf8A:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZZM_A_SAMA401_1
(UNCHARACTERIZED
PROTEIN MJ0883)		 5ols RHAMNOGALACTURONAN
LYASE
(Bacteroides
thetaiotaomicron) 		3 / 3 ARG A 319
ASP A 215
ASN A 324
 GTR  A 608 (-3.0A)
CA  A 601 (-2.1A)
RAM  A 607 (-2.8A)
 0.78A 2zzmA-5olsA:
undetectable		 2zzmA-5olsA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HII_A_PNTA901_0
(AMILORIDE-SENSITIVE
AMINE OXIDASE)		 5ols RHAMNOGALACTURONAN
LYASE
(Bacteroides
thetaiotaomicron) 		5 / 12 ASP A 246
GLY A 269
TYR A 270
TYR A 322
ASN A 324
 CA  A 602 (-2.5A)
None
None
GTR  A 608 (-4.9A)
RAM  A 607 (-2.8A)
 1.43A 3hiiA-5olsA:
undetectable		 3hiiA-5olsA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEV_E_KANE301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 4mij TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT
(Polaromonas
sp.
JS666) 		5 / 11 SER A 237
HIS A 236
ASN A 214
GLU A 213
GLU A 241
 None
None
GTR  A 405 ( 3.0A)
CL  A 404 (-3.6A)
GTR  A 405 ( 2.9A)
 1.31A 4fevE-4mijA:
undetectable		 4fevE-4mijA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEV_E_KANE301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 4n8y PUTATIVE TRAP-TYPE
C4-DICARBOXYLATE
TRANSPORT SYSTEM,
BINDING PERIPLASMIC
PROTEIN (DCTP
SUBUNIT)
(Bradyrhizobium
sp.
BTAi1) 		5 / 11 SER A 229
HIS A 228
ASN A 206
GLU A 205
GLU A 233
 None
None
ADA  A 401 (-2.9A)
None
GTR  A 402 (-2.8A)
 1.28A 4fevE-4n8yA:
undetectable		 4fevE-4n8yA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEV_E_KANE301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 4ovr TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT
(Xanthobacter
autotrophicus) 		5 / 11 SER A 231
HIS A 230
ASN A 208
GLU A 207
GLU A 235
 None
None
GTR  A 403 (-3.0A)
None
GTR  A 403 (-2.9A)
 1.29A 4fevE-4ovrA:
0.2		 4fevE-4ovrA:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEW_C_KANC301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 4n8y PUTATIVE TRAP-TYPE
C4-DICARBOXYLATE
TRANSPORT SYSTEM,
BINDING PERIPLASMIC
PROTEIN (DCTP
SUBUNIT)
(Bradyrhizobium
sp.
BTAi1) 		5 / 12 ASN A 206
GLU A 233
SER A 229
HIS A 228
ARG A 166
 ADA  A 401 (-2.9A)
GTR  A 402 (-2.8A)
None
None
ADA  A 401 (-3.0A)
 1.35A 4fewC-4n8yA:
0.0
4fewD-4n8yA:
0.1
4fewF-4n8yA:
0.8		 4fewC-4n8yA:
22.06
4fewD-4n8yA:
22.06
4fewF-4n8yA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEW_E_KANE301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 4mij TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT
(Polaromonas
sp.
JS666) 		5 / 11 ASN A 214
GLU A 213
GLU A 241
SER A 237
HIS A 236
 GTR  A 405 ( 3.0A)
CL  A 404 (-3.6A)
GTR  A 405 ( 2.9A)
None
None
 1.29A 4fewE-4mijA:
0.1
4fewF-4mijA:
0.8		 4fewE-4mijA:
23.14
4fewF-4mijA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEW_E_KANE301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 4n8y PUTATIVE TRAP-TYPE
C4-DICARBOXYLATE
TRANSPORT SYSTEM,
BINDING PERIPLASMIC
PROTEIN (DCTP
SUBUNIT)
(Bradyrhizobium
sp.
BTAi1) 		5 / 11 ASN A 206
GLU A 205
GLU A 233
SER A 229
HIS A 228
 ADA  A 401 (-2.9A)
None
GTR  A 402 (-2.8A)
None
None
 1.27A 4fewE-4n8yA:
0.0
4fewF-4n8yA:
0.8		 4fewE-4n8yA:
22.06
4fewF-4n8yA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEW_E_KANE301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 4ovr TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT
(Xanthobacter
autotrophicus) 		5 / 11 ASN A 208
GLU A 207
GLU A 235
SER A 231
HIS A 230
 GTR  A 403 (-3.0A)
None
GTR  A 403 (-2.9A)
None
None
 1.28A 4fewE-4ovrA:
undetectable
4fewF-4ovrA:
0.7		 4fewE-4ovrA:
23.39
4fewF-4ovrA:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_H_KANH301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 4mij TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT
(Polaromonas
sp.
JS666) 		5 / 10 SER A 237
HIS A 236
ASN A 214
GLU A 213
GLU A 241
 None
None
GTR  A 405 ( 3.0A)
CL  A 404 (-3.6A)
GTR  A 405 ( 2.9A)
 1.29A 4gkhG-4mijA:
0.4
4gkhH-4mijA:
0.5		 4gkhG-4mijA:
23.14
4gkhH-4mijA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_H_KANH301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 4n8y PUTATIVE TRAP-TYPE
C4-DICARBOXYLATE
TRANSPORT SYSTEM,
BINDING PERIPLASMIC
PROTEIN (DCTP
SUBUNIT)
(Bradyrhizobium
sp.
BTAi1) 		5 / 10 SER A 229
HIS A 228
ASN A 206
GLU A 205
GLU A 233
 None
None
ADA  A 401 (-2.9A)
None
GTR  A 402 (-2.8A)
 1.27A 4gkhG-4n8yA:
0.1
4gkhH-4n8yA:
0.3		 4gkhG-4n8yA:
22.06
4gkhH-4n8yA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_H_KANH301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 4ovr TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT
(Xanthobacter
autotrophicus) 		5 / 10 SER A 231
HIS A 230
ASN A 208
GLU A 207
GLU A 235
 None
None
GTR  A 403 (-3.0A)
None
GTR  A 403 (-2.9A)
 1.28A 4gkhG-4ovrA:
0.0
4gkhH-4ovrA:
0.0		 4gkhG-4ovrA:
23.39
4gkhH-4ovrA:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_L_KANL301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 4ovr TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT
(Xanthobacter
autotrophicus) 		5 / 10 SER A 231
HIS A 230
ASN A 208
GLU A 207
GLU A 235
 None
None
GTR  A 403 (-3.0A)
None
GTR  A 403 (-2.9A)
 1.30A 4gkhK-4ovrA:
0.0
4gkhL-4ovrA:
0.0		 4gkhK-4ovrA:
23.39
4gkhL-4ovrA:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKI_D_KAND301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 4mij TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT
(Polaromonas
sp.
JS666) 		5 / 11 SER A 237
HIS A 236
ASN A 214
GLU A 213
GLU A 241
 None
None
GTR  A 405 ( 3.0A)
CL  A 404 (-3.6A)
GTR  A 405 ( 2.9A)
 1.33A 4gkiC-4mijA:
0.5
4gkiD-4mijA:
0.5		 4gkiC-4mijA:
23.14
4gkiD-4mijA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKI_D_KAND301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 4n8y PUTATIVE TRAP-TYPE
C4-DICARBOXYLATE
TRANSPORT SYSTEM,
BINDING PERIPLASMIC
PROTEIN (DCTP
SUBUNIT)
(Bradyrhizobium
sp.
BTAi1) 		5 / 11 SER A 229
HIS A 228
ASN A 206
GLU A 205
GLU A 233
 None
None
ADA  A 401 (-2.9A)
None
GTR  A 402 (-2.8A)
 1.30A 4gkiC-4n8yA:
undetectable
4gkiD-4n8yA:
undetectable		 4gkiC-4n8yA:
22.06
4gkiD-4n8yA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKI_D_KAND301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 4ovr TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT
(Xanthobacter
autotrophicus) 		5 / 11 SER A 231
HIS A 230
ASN A 208
GLU A 207
GLU A 235
 None
None
GTR  A 403 (-3.0A)
None
GTR  A 403 (-2.9A)
 1.31A 4gkiC-4ovrA:
undetectable
4gkiD-4ovrA:
undetectable		 4gkiC-4ovrA:
23.39
4gkiD-4ovrA:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKI_H_KANH301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 4mij TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT
(Polaromonas
sp.
JS666) 		5 / 10 SER A 237
HIS A 236
ASN A 214
GLU A 213
GLU A 241
 None
None
GTR  A 405 ( 3.0A)
CL  A 404 (-3.6A)
GTR  A 405 ( 2.9A)
 1.31A 4gkiG-4mijA:
0.9
4gkiH-4mijA:
0.2		 4gkiG-4mijA:
23.14
4gkiH-4mijA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKI_H_KANH301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 4n8y PUTATIVE TRAP-TYPE
C4-DICARBOXYLATE
TRANSPORT SYSTEM,
BINDING PERIPLASMIC
PROTEIN (DCTP
SUBUNIT)
(Bradyrhizobium
sp.
BTAi1) 		5 / 10 SER A 229
HIS A 228
ASN A 206
GLU A 205
GLU A 233
 None
None
ADA  A 401 (-2.9A)
None
GTR  A 402 (-2.8A)
 1.29A 4gkiG-4n8yA:
0.8
4gkiH-4n8yA:
0.2		 4gkiG-4n8yA:
22.06
4gkiH-4n8yA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKI_H_KANH301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 4ovr TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT
(Xanthobacter
autotrophicus) 		5 / 10 SER A 231
HIS A 230
ASN A 208
GLU A 207
GLU A 235
 None
None
GTR  A 403 (-3.0A)
None
GTR  A 403 (-2.9A)
 1.29A 4gkiG-4ovrA:
0.7
4gkiH-4ovrA:
undetectable		 4gkiG-4ovrA:
23.39
4gkiH-4ovrA:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5I_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 4mij TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT
(Polaromonas
sp.
JS666) 		3 / 3 ASP A  37
ARG A 174
ARG A 154
 None
GTR  A 405 (-3.0A)
ADA  A 406 ( 3.0A)
 0.96A 4x5iA-4mijA:
undetectable		 4x5iA-4mijA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5I_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 4n17 TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT
(Burkholderia
ambifaria) 		3 / 3 ASP A  33
ARG A 169
ARG A 149
 None
GTR  A 401 (-3.0A)
GTR  A 401 (-3.1A)
 0.96A 4x5iA-4n17A:
undetectable		 4x5iA-4n17A:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5I_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 4n8y PUTATIVE TRAP-TYPE
C4-DICARBOXYLATE
TRANSPORT SYSTEM,
BINDING PERIPLASMIC
PROTEIN (DCTP
SUBUNIT)
(Bradyrhizobium
sp.
BTAi1) 		3 / 3 ASP A  29
ARG A 166
ARG A 145
 None
ADA  A 401 (-3.0A)
GTR  A 402 (-3.0A)
 0.98A 4x5iA-4n8yA:
undetectable		 4x5iA-4n8yA:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5I_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 4ovr TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT
(Xanthobacter
autotrophicus) 		3 / 3 ASP A  32
ARG A 168
ARG A 148
 None
GTR  A 403 (-2.9A)
GTR  A 403 (-3.1A)
 0.97A 4x5iA-4ovrA:
undetectable		 4x5iA-4ovrA:
16.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_N_EVPN2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 4ovr TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT
(Xanthobacter
autotrophicus) 		4 / 6 SER A 228
GLU A 229
ARG A 168
GLY A 205
 None
None
GTR  A 403 (-2.9A)
None
 0.94A 5cdnR-4ovrA:
undetectable
5cdnS-4ovrA:
undetectable		 5cdnR-4ovrA:
20.45
5cdnS-4ovrA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_N_EVPN2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 5ols RHAMNOGALACTURONAN
LYASE
(Bacteroides
thetaiotaomicron) 		4 / 6 GLU A 276
GLY A 320
ARG A 319
GLY A 341
 None
None
GTR  A 608 (-3.0A)
None
 0.73A 5cdnR-5olsA:
undetectable
5cdnS-5olsA:
undetectable		 5cdnR-5olsA:
20.53
5cdnS-5olsA:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_O_EVPO2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 5ols RHAMNOGALACTURONAN
LYASE
(Bacteroides
thetaiotaomicron) 		4 / 6 GLU A 276
GLY A 320
ARG A 319
GLY A 341
 None
None
GTR  A 608 (-3.0A)
None
 0.95A 5cdnC-5olsA:
undetectable
5cdnD-5olsA:
undetectable		 5cdnC-5olsA:
20.53
5cdnD-5olsA:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H3D_A_DHIA601_0
(DUF2338
DOMAIN-CONTAINING
PROTEIN)		 4n17 TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT
(Burkholderia
ambifaria) 		4 / 5 TYR A 267
ASN A  91
ARG A  89
PHE A  39
 None
GTR  A 401 (-4.1A)
GTR  A 401 (-2.7A)
None
 1.31A 6h3dA-4n17A:
undetectable		 6h3dA-4n17A:
21.49