SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'GTP'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ACJ_A_THAA999_1
(ACETYLCHOLINESTERASE)		 3ffu PROBABLE
PYROPHOSPHOHYDROLASE
(Bdellovibrio
bacteriovorus) 		5 / 9 GLY A  54
GLU A  51
TRP A 121
HIS A 116
GLY A  38
 GTP  A4033 ( 4.0A)
GTP  A4033 (-3.5A)
None
None
None
 1.39A 1acjA-3ffuA:
undetectable		 1acjA-3ffuA:
16.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CD2_A_FOLA307_1
(DIHYDROFOLATE
REDUCTASE)		 4ncn EUKARYOTIC
TRANSLATION
INITIATION FACTOR
5B-LIKE PROTEIN
(Chaetomium
thermophilum) 		3 / 3 GLU A 552
ILE A 556
ARG A 605
 MG  A1002 ( 4.0A)
GTP  A1001 ( 3.7A)
None
 0.66A 1cd2A-4ncnA:
undetectable		 1cd2A-4ncnA:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DSC_C_DVAC2_0
(ACTINOMYCIN D)		 1w5e FTSZ
(Methanocaldococc
us
jannaschii) 		3 / 3 THR A 135
PRO A 101
THR A 137
 GTP  A 500 (-3.6A)
None
None
 0.96A 1dscC-1w5eA:
undetectable		 1dscC-1w5eA:
3.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7A_A_PFLA4002_1
(SERUM ALBUMIN)		 1z0k GTP-BINDING PROTEIN
(Homo
sapiens) 		3 / 3 PHE A  33
LEU A  24
SER A 151
 GTP  A1200 (-4.4A)
None
GTP  A1200 (-3.5A)
 0.74A 1e7aA-1z0kA:
undetectable		 1e7aA-1z0kA:
12.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7A_A_PFLA4002_1
(SERUM ALBUMIN)		 3rap PROTEIN (G PROTEIN
RAP2A)
(Homo
sapiens) 		3 / 3 PHE R  28
LEU R  19
SER R 146
 GTP  R 180 (-4.3A)
None
GTP  R 180 (-3.4A)
 0.75A 1e7aA-3rapR:
undetectable		 1e7aA-3rapR:
13.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7A_A_PFLA4002_1
(SERUM ALBUMIN)		 5z2m -
(-) 		3 / 3 PHE A  33
LEU A  24
SER A 155
 GTP  A 202 (-4.2A)
None
GTP  A 202 (-3.4A)
 0.74A 1e7aA-5z2mA:
undetectable		 1e7aA-5z2mA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_F_ACTF3008_0
(BETA-CARBONIC
ANHYDRASE)		 2x60 MANNOSE-1-PHOSPHATE
GUANYLYLTRANSFERASE
(Thermotoga
maritima) 		4 / 8 PHE A  27
TYR A  61
GLY A  10
GLY A   9
 None
None
GTP  A 601 (-3.3A)
GTP  A 601 (-3.1A)
 0.75A 1ekjE-2x60A:
undetectable
1ekjF-2x60A:
undetectable		 1ekjE-2x60A:
20.54
1ekjF-2x60A:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_F_CCSF47_0
(GLUTATHIONE
S-TRANSFERASE)		 5hzh RAS-RELATED C3
BOTULINUM TOXIN
SUBSTRATE
1,NPH1-1,RAS-RELATED
C3 BOTULINUM TOXIN
SUBSTRATE 1
(Avena
sativa;
Homo
sapiens) 		4 / 5 THR A  35
LEU A 210
GLY A 209
TYR A 213
 MG  A 403 ( 3.3A)
None
GTP  A 401 (-4.3A)
None
 1.26A 1gtiF-5hzhA:
undetectable		 1gtiF-5hzhA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HMY_A_SAMA328_0
(HAEIII
METHYLTRANSFERASE)		 3ldu PUTATIVE METHYLASE
(Clostridioides
difficile) 		4 / 8 ASP A 289
THR A 291
PRO A 307
LEU A 321
 GTP  A 383 ( 3.8A)
GTP  A 383 ( 4.3A)
GTP  A 383 (-3.7A)
None
 0.89A 1hmyA-3lduA:
6.6		 1hmyA-3lduA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ISM_B_NCAB305_0
(BONE MARROW STROMAL
CELL ANTIGEN 1)		 2x60 MANNOSE-1-PHOSPHATE
GUANYLYLTRANSFERASE
(Thermotoga
maritima) 		4 / 7 HIS A 110
LEU A   7
ASP A 109
PHE A 193
 None
GTP  A 601 (-3.7A)
GTP  A 601 ( 3.7A)
None
 1.27A 1ismB-2x60A:
undetectable		 1ismB-2x60A:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JNO_A_DVAA6_0
(GRAMICIDIN A)		 3wyf GSP1P
(Saccharomyces
cerevisiae) 		3 / 3 ALA A  69
VAL A  18
TRP A 106
 GTP  A 301 ( 4.9A)
None
None
 0.81A 1jnoA-3wyfA:
undetectable		 1jnoA-3wyfA:
6.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JNO_A_DVAA6_0
(GRAMICIDIN A)		 5dis GTP-BINDING NUCLEAR
PROTEIN RAN
(Homo
sapiens) 		3 / 3 ALA B  67
VAL B  16
TRP B 104
 GTP  B 201 ( 4.6A)
None
None
 0.83A 1jnoA-5disB:
undetectable		 1jnoA-5disB:
7.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JNO_B_DVAB6_0
(GRAMICIDIN A)		 3wyf GSP1P
(Saccharomyces
cerevisiae) 		3 / 3 ALA A  69
VAL A  18
TRP A 106
 GTP  A 301 ( 4.9A)
None
None
 0.81A 1jnoB-3wyfA:
undetectable		 1jnoB-3wyfA:
6.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JNO_B_DVAB6_0
(GRAMICIDIN A)		 5dis GTP-BINDING NUCLEAR
PROTEIN RAN
(Homo
sapiens) 		3 / 3 ALA B  67
VAL B  16
TRP B 104
 GTP  B 201 ( 4.6A)
None
None
 0.84A 1jnoB-5disB:
undetectable		 1jnoB-5disB:
7.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JO3_A_DVAA6_0
(GRAMICIDIN B)		 3wyf GSP1P
(Saccharomyces
cerevisiae) 		3 / 3 ALA A  69
VAL A  18
TRP A 106
 GTP  A 301 ( 4.9A)
None
None
 0.89A 1jo3A-3wyfA:
undetectable		 1jo3A-3wyfA:
6.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JO3_A_DVAA6_0
(GRAMICIDIN B)		 5dis GTP-BINDING NUCLEAR
PROTEIN RAN
(Homo
sapiens) 		3 / 3 ALA B  67
VAL B  16
TRP B 104
 GTP  B 201 ( 4.6A)
None
None
 0.91A 1jo3A-5disB:
undetectable		 1jo3A-5disB:
7.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JO3_B_DVAB6_0
(GRAMICIDIN B)		 3wyf GSP1P
(Saccharomyces
cerevisiae) 		3 / 3 ALA A  69
VAL A  18
TRP A 106
 GTP  A 301 ( 4.9A)
None
None
 0.88A 1jo3B-3wyfA:
undetectable		 1jo3B-3wyfA:
6.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JO3_B_DVAB6_0
(GRAMICIDIN B)		 5dis GTP-BINDING NUCLEAR
PROTEIN RAN
(Homo
sapiens) 		3 / 3 ALA B  67
VAL B  16
TRP B 104
 GTP  B 201 ( 4.6A)
None
None
 0.91A 1jo3B-5disB:
undetectable		 1jo3B-5disB:
7.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L7F_A_BCZA801_0
(NEURAMINIDASE)		 3ffu PROBABLE
PYROPHOSPHOHYDROLASE
(Bdellovibrio
bacteriovorus) 		5 / 12 GLU A  74
LEU A  71
ILE A  99
GLU A  51
ARG A  40
 MG  A 156 (-2.3A)
None
GTP  A4033 ( 4.9A)
GTP  A4033 (-3.5A)
GTP  A4033 (-3.1A)
 1.30A 1l7fA-3ffuA:
undetectable		 1l7fA-3ffuA:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LIK_A_ADNA699_1
(ADENOSINE KINASE)		 5m3c DIGUANYLATE CYCLASE
(Pseudomonas
aeruginosa) 		5 / 12 ASP A 863
LEU A 816
GLY A 862
ASN A 854
THR A 814
 GTP  A1304 (-3.6A)
None
GTP  A1304 (-3.4A)
GTP  A1304 (-2.9A)
None
 1.11A 1likA-5m3cA:
undetectable		 1likA-5m3cA:
12.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MAG_A_DVAA6_0
(GRAMICIDIN A)		 3wyf GSP1P
(Saccharomyces
cerevisiae) 		3 / 3 ALA A  69
VAL A  18
TRP A 106
 GTP  A 301 ( 4.9A)
None
None
 0.87A 1magA-3wyfA:
undetectable		 1magA-3wyfA:
6.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MAG_A_DVAA6_0
(GRAMICIDIN A)		 5dis GTP-BINDING NUCLEAR
PROTEIN RAN
(Homo
sapiens) 		3 / 3 ALA B  67
VAL B  16
TRP B 104
 GTP  B 201 ( 4.6A)
None
None
 0.89A 1magA-5disB:
undetectable		 1magA-5disB:
7.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MAG_B_DVAB6_0
(GRAMICIDIN A)		 3wyf GSP1P
(Saccharomyces
cerevisiae) 		3 / 3 ALA A  69
VAL A  18
TRP A 106
 GTP  A 301 ( 4.9A)
None
None
 0.87A 1magB-3wyfA:
undetectable		 1magB-3wyfA:
6.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MAG_B_DVAB6_0
(GRAMICIDIN A)		 5dis GTP-BINDING NUCLEAR
PROTEIN RAN
(Homo
sapiens) 		3 / 3 ALA B  67
VAL B  16
TRP B 104
 GTP  B 201 ( 4.6A)
None
None
 0.89A 1magB-5disB:
undetectable		 1magB-5disB:
7.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_E_THAE5_1
(LIVER
CARBOXYLESTERASE I)		 3ffu PROBABLE
PYROPHOSPHOHYDROLASE
(Bdellovibrio
bacteriovorus) 		5 / 12 GLY A  55
VAL A  24
LEU A  67
LEU A  29
HIS A 116
 GTP  A4033 (-2.8A)
GTP  A4033 (-4.4A)
None
None
None
 1.17A 1mx1E-3ffuA:
undetectable		 1mx1E-3ffuA:
14.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N2X_B_SAMB402_0
(S-ADENOSYL-METHYLTRA
NSFERASE MRAW)		 4ncn EUKARYOTIC
TRANSLATION
INITIATION FACTOR
5B-LIKE PROTEIN
(Chaetomium
thermophilum) 		5 / 12 THR A 537
GLY A 535
GLY A 530
GLY A 555
ASN A 547
 MG  A1002 ( 3.1A)
GTP  A1001 (-3.1A)
None
NA  A1003 ( 4.6A)
GOL  A1006 (-3.8A)
 0.92A 1n2xB-4ncnA:
undetectable		 1n2xB-4ncnA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NG8_A_DVAA6_0
(GRAMICIDIN A)		 3wyf GSP1P
(Saccharomyces
cerevisiae) 		3 / 3 ALA A  69
VAL A  18
TRP A 106
 GTP  A 301 ( 4.9A)
None
None
 0.83A 1ng8A-3wyfA:
undetectable		 1ng8A-3wyfA:
6.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NG8_A_DVAA6_0
(GRAMICIDIN A)		 5dis GTP-BINDING NUCLEAR
PROTEIN RAN
(Homo
sapiens) 		3 / 3 ALA B  67
VAL B  16
TRP B 104
 GTP  B 201 ( 4.6A)
None
None
 0.85A 1ng8A-5disB:
undetectable		 1ng8A-5disB:
8.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NG8_B_DVAB6_0
(GRAMICIDIN A)		 3wyf GSP1P
(Saccharomyces
cerevisiae) 		3 / 3 ALA A  69
VAL A  18
TRP A 106
 GTP  A 301 ( 4.9A)
None
None
 0.83A 1ng8B-3wyfA:
undetectable		 1ng8B-3wyfA:
6.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NG8_B_DVAB6_0
(GRAMICIDIN A)		 5dis GTP-BINDING NUCLEAR
PROTEIN RAN
(Homo
sapiens) 		3 / 3 ALA B  67
VAL B  16
TRP B 104
 GTP  B 201 ( 4.6A)
None
None
 0.85A 1ng8B-5disB:
undetectable		 1ng8B-5disB:
8.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NRU_A_DVAA6_0
(GRAMICIDIN A)		 3wyf GSP1P
(Saccharomyces
cerevisiae) 		3 / 3 ALA A  69
VAL A  18
TRP A 106
 GTP  A 301 ( 4.9A)
None
None
 0.86A 1nruA-3wyfA:
undetectable		 1nruA-3wyfA:
6.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NRU_A_DVAA6_0
(GRAMICIDIN A)		 5dis GTP-BINDING NUCLEAR
PROTEIN RAN
(Homo
sapiens) 		3 / 3 ALA B  67
VAL B  16
TRP B 104
 GTP  B 201 ( 4.6A)
None
None
 0.89A 1nruA-5disB:
undetectable		 1nruA-5disB:
7.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NRU_B_DVAB6_0
(GRAMICIDIN A)		 3wyf GSP1P
(Saccharomyces
cerevisiae) 		3 / 3 ALA A  69
VAL A  18
TRP A 106
 GTP  A 301 ( 4.9A)
None
None
 0.87A 1nruB-3wyfA:
undetectable		 1nruB-3wyfA:
6.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NRU_B_DVAB6_0
(GRAMICIDIN A)		 5dis GTP-BINDING NUCLEAR
PROTEIN RAN
(Homo
sapiens) 		3 / 3 ALA B  67
VAL B  16
TRP B 104
 GTP  B 201 ( 4.6A)
None
None
 0.89A 1nruB-5disB:
undetectable		 1nruB-5disB:
7.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_D_BEZD507_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 5nd4 TUBULIN ALPHA CHAIN
(Bos
taurus) 		4 / 7 PHE A 169
ALA A 270
ILE A 171
ILE A 209
 None
None
GTP  A 500 ( 4.7A)
None
 0.91A 1oniD-5nd4A:
4.7
1oniF-5nd4A:
4.8		 1oniD-5nd4A:
16.21
1oniF-5nd4A:
16.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P6K_A_MTLA870_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5w3f TUBULIN ALPHA-1
CHAIN
(Saccharomyces
cerevisiae) 		4 / 8 SER A 224
GLN A  15
PHE A 225
ASN A 227
 None
None
GTP  A 502 (-3.8A)
None
 1.04A 1p6kA-5w3fA:
undetectable		 1p6kA-5w3fA:
23.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P6K_B_MTLB871_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5w3f TUBULIN ALPHA-1
CHAIN
(Saccharomyces
cerevisiae) 		4 / 8 SER A 224
GLN A  15
PHE A 225
ASN A 227
 None
None
GTP  A 502 (-3.8A)
None
 1.06A 1p6kB-5w3fA:
undetectable		 1p6kB-5w3fA:
23.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QAO_A_SAMA245_0
(ERMC'
METHYLTRANSFERASE)		 3ldu PUTATIVE METHYLASE
(Clostridioides
difficile) 		6 / 12 GLY A 202
ILE A 262
ASP A 263
ASP A 289
ASN A 305
PRO A 307
 GTP  A 383 (-2.6A)
GTP  A 383 (-4.2A)
None
GTP  A 383 ( 3.8A)
GTP  A 383 (-4.2A)
GTP  A 383 (-3.7A)
 0.89A 1qaoA-3lduA:
10.2		 1qaoA-3lduA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS6_A_MTLA870_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5w3f TUBULIN ALPHA-1
CHAIN
(Saccharomyces
cerevisiae) 		4 / 8 SER A 224
GLN A  15
PHE A 225
ASN A 227
 None
None
GTP  A 502 (-3.8A)
None
 1.07A 1rs6A-5w3fA:
undetectable		 1rs6A-5w3fA:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS6_B_MTLB871_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5w3f TUBULIN ALPHA-1
CHAIN
(Saccharomyces
cerevisiae) 		4 / 8 SER A 224
GLN A  15
PHE A 225
ASN A 227
 None
None
GTP  A 502 (-3.8A)
None
 1.07A 1rs6B-5w3fA:
undetectable		 1rs6B-5w3fA:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS7_B_MTLB871_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5w3f TUBULIN ALPHA-1
CHAIN
(Saccharomyces
cerevisiae) 		4 / 8 SER A 224
GLN A  15
PHE A 225
ASN A 227
 None
None
GTP  A 502 (-3.8A)
None
 1.08A 1rs7B-5w3fA:
undetectable		 1rs7B-5w3fA:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SG9_A_SAMA301_1
(HEMK PROTEIN)		 5ucy TUBULIN ALPHA CHAIN
(Tetrahymena
thermophila) 		4 / 4 THR A 179
GLY A  10
ASP A  69
ALA A  99
 GTP  A 501 (-3.6A)
GTP  A 501 (-2.2A)
GTP  A 501 ( 2.1A)
GTP  A 501 (-2.9A)
 1.11A 1sg9A-5ucyA:
undetectable		 1sg9A-5ucyA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SQF_A_SAMA430_1
(SUN PROTEIN)		 3ldu PUTATIVE METHYLASE
(Clostridioides
difficile) 		3 / 3 PRO A 199
ASP A 261
ASP A 289
 None
GTP  A 383 (-3.0A)
GTP  A 383 ( 3.8A)
 0.77A 1sqfA-3lduA:
10.6		 1sqfA-3lduA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T03_P_TFOP822_1
(POL POLYPROTEIN
SYNTHETIC
OLIGONUCLEOTIDE
PRIMER)		 5xe0 GENOME POLYPROTEIN
(Enterovirus
D) 		4 / 7 TYR A 322
ASP A 324
ASP A 325
LYS A 355
 None
GTP  A 501 ( 4.2A)
None
GTP  A 501 (-3.5A)
 0.91A 1t03A-5xe0A:
4.2		 1t03A-5xe0A:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VID_A_SAMA301_1
(CATECHOL
O-METHYLTRANSFERASE)		 2wkp NPH1-1, RAS-RELATED
C3 BOTULINUM TOXIN
SUBSTRATE 1
(Avena
sativa;
Homo
sapiens) 		4 / 5 GLU A 699
TYR A 682
SER A 701
ASP A 664
 None
None
GTP  A1724 (-3.6A)
None
 1.34A 1vidA-2wkpA:
undetectable		 1vidA-2wkpA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VID_A_SAMA301_1
(CATECHOL
O-METHYLTRANSFERASE)		 5hzh RAS-RELATED C3
BOTULINUM TOXIN
SUBSTRATE
1,NPH1-1,RAS-RELATED
C3 BOTULINUM TOXIN
SUBSTRATE 1
(Avena
sativa;
Homo
sapiens) 		4 / 5 GLU A 305
TYR A 288
SER A 307
ASP A 270
 None
None
GTP  A 401 (-3.5A)
None
 1.38A 1vidA-5hzhA:
undetectable		 1vidA-5hzhA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZGY_A_BRLA503_2
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 2qv6 GTP CYCLOHYDROLASE
III
(Methanocaldococc
us
jannaschii) 		4 / 5 ILE A 210
ILE A 180
ILE A 142
LEU A 170
 None
GTP  A 300 (-3.8A)
GTP  A 300 (-4.1A)
None
 0.89A 1zgyA-2qv6A:
undetectable		 1zgyA-2qv6A:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZQ_A_MTLA870_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5w3f TUBULIN ALPHA-1
CHAIN
(Saccharomyces
cerevisiae) 		4 / 8 SER A 224
GLN A  15
PHE A 225
ASN A 227
 None
None
GTP  A 502 (-3.8A)
None
 1.05A 1zzqA-5w3fA:
undetectable		 1zzqA-5w3fA:
24.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZQ_B_MTLB871_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5w3f TUBULIN ALPHA-1
CHAIN
(Saccharomyces
cerevisiae) 		4 / 8 SER A 224
GLN A  15
PHE A 225
ASN A 227
 None
None
GTP  A 502 (-3.8A)
None
 1.07A 1zzqB-5w3fA:
undetectable		 1zzqB-5w3fA:
24.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZU_A_MTLA870_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5w3f TUBULIN ALPHA-1
CHAIN
(Saccharomyces
cerevisiae) 		4 / 8 SER A 224
GLN A  15
PHE A 225
ASN A 227
 None
None
GTP  A 502 (-3.8A)
None
 1.09A 1zzuA-5w3fA:
0.4		 1zzuA-5w3fA:
24.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZU_B_MTLB871_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5w3f TUBULIN ALPHA-1
CHAIN
(Saccharomyces
cerevisiae) 		4 / 8 SER A 224
GLN A  15
PHE A 225
ASN A 227
 None
None
GTP  A 502 (-3.8A)
None
 1.06A 1zzuB-5w3fA:
undetectable		 1zzuB-5w3fA:
24.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B25_A_SAMA601_0
(HYPOTHETICAL PROTEIN)		 1wdt ELONGATION FACTOR G
HOMOLOG
(Thermus
thermophilus) 		5 / 12 THR A  61
GLY A  21
GLY A  19
GLY A  83
ASP A 137
 MG  A 701 ( 3.0A)
GTP  A 700 (-3.3A)
GTP  A 700 (-3.6A)
GTP  A 700 (-3.1A)
GTP  A 700 (-2.8A)
 0.94A 2b25A-1wdtA:
undetectable		 2b25A-1wdtA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B25_A_SAMA601_0
(HYPOTHETICAL PROTEIN)		 1yhn RAS-RELATED PROTEIN
RAB-7
(Homo
sapiens) 		5 / 12 THR A  40
GLY A  20
GLY A  18
GLY A  66
ASP A 128
 MG  A 302 ( 2.8A)
GTP  A 301 (-2.9A)
GTP  A 301 (-2.6A)
GTP  A 301 (-3.3A)
GTP  A 301 (-2.8A)
 1.06A 2b25A-1yhnA:
undetectable		 2b25A-1yhnA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B25_A_SAMA601_0
(HYPOTHETICAL PROTEIN)		 1z0k GTP-BINDING PROTEIN
(Homo
sapiens) 		5 / 12 THR A  40
GLY A  20
GLY A  18
GLY A  66
ASP A 124
 MG  A1201 ( 3.1A)
GTP  A1200 (-3.3A)
GTP  A1200 (-3.6A)
GTP  A1200 (-3.5A)
GTP  A1200 (-2.9A)
 0.99A 2b25A-1z0kA:
undetectable		 2b25A-1z0kA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B25_A_SAMA601_0
(HYPOTHETICAL PROTEIN)		 2gzh RAS-RELATED PROTEIN
RAB-11A
(Homo
sapiens) 		5 / 12 THR A  43
GLY A  23
GLY A  21
GLY A  69
ASP A 127
 MG  A 950 ( 3.2A)
GTP  A 900 (-3.1A)
GTP  A 900 (-3.8A)
GTP  A 900 (-3.7A)
GTP  A 900 (-2.9A)
 1.06A 2b25A-2gzhA:
undetectable		 2b25A-2gzhA:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B25_A_SAMA601_0
(HYPOTHETICAL PROTEIN)		 2zet RAS-RELATED PROTEIN
RAB-27B
(Mus
musculus) 		5 / 12 THR A  41
GLY A  21
GLY A  19
GLY A  77
ASP A 136
 GTP  A 203 ( 3.4A)
GTP  A 203 (-3.0A)
GTP  A 203 (-3.3A)
GTP  A 203 (-3.3A)
GTP  A 203 (-2.7A)
 1.04A 2b25A-2zetA:
undetectable		 2b25A-2zetA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B25_A_SAMA601_0
(HYPOTHETICAL PROTEIN)		 3rap PROTEIN (G PROTEIN
RAP2A)
(Homo
sapiens) 		5 / 12 THR R  35
GLY R  15
GLY R  13
GLY R  60
ASP R 119
 MG  R 200 ( 2.7A)
GTP  R 180 (-3.1A)
GTP  R 180 (-3.5A)
GTP  R 180 (-3.3A)
GTP  R 180 (-2.9A)
 0.96A 2b25A-3rapR:
2.3		 2b25A-3rapR:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B25_A_SAMA601_0
(HYPOTHETICAL PROTEIN)		 3wyf GSP1P
(Saccharomyces
cerevisiae) 		5 / 12 THR A  44
GLY A  24
GLY A  22
GLY A  70
ASP A 127
 MG  A 302 ( 2.9A)
GTP  A 301 (-3.4A)
GTP  A 301 (-3.6A)
GTP  A 301 (-3.4A)
GTP  A 301 (-2.9A)
 1.00A 2b25A-3wyfA:
undetectable		 2b25A-3wyfA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B25_A_SAMA601_0
(HYPOTHETICAL PROTEIN)		 4qxa RAS-RELATED PROTEIN
RAB-9A
(Mus
musculus) 		5 / 12 THR A  39
GLY A  19
GLY A  17
GLY A  65
ASP A 127
 MG  A 302 ( 3.2A)
GTP  A 301 (-3.2A)
GTP  A 301 (-3.3A)
GTP  A 301 (-3.3A)
GTP  A 301 (-2.9A)
 0.96A 2b25A-4qxaA:
undetectable		 2b25A-4qxaA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B25_A_SAMA601_0
(HYPOTHETICAL PROTEIN)		 5dis GTP-BINDING NUCLEAR
PROTEIN RAN
(Homo
sapiens) 		5 / 12 THR B  42
GLY B  22
GLY B  20
GLY B  68
ASP B 125
 MG  B 202 ( 2.9A)
GTP  B 201 (-3.3A)
GTP  B 201 (-3.6A)
GTP  B 201 (-3.8A)
GTP  B 201 (-2.6A)
 1.00A 2b25A-5disB:
undetectable		 2b25A-5disB:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B25_A_SAMA601_0
(HYPOTHETICAL PROTEIN)		 5z2m -
(-) 		5 / 12 THR A  40
GLY A  20
GLY A  18
GLY A  66
ASP A 128
 MG  A 201 ( 3.0A)
GTP  A 202 (-3.3A)
GTP  A 202 (-3.4A)
GTP  A 202 (-3.2A)
GTP  A 202 (-2.7A)
 0.98A 2b25A-5z2mA:
2.4		 2b25A-5z2mA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CL5_B_SAMB1217_1
(CATECHOL
O-METHYLTRANSFERASE)		 2wkp NPH1-1, RAS-RELATED
C3 BOTULINUM TOXIN
SUBSTRATE 1
(Avena
sativa;
Homo
sapiens) 		4 / 6 GLU A 699
TYR A 682
SER A 701
ASP A 664
 None
None
GTP  A1724 (-3.6A)
None
 1.40A 2cl5B-2wkpA:
undetectable		 2cl5B-2wkpA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIM_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 5a96 POLYHEDRIN
(Cypovirus
14) 		4 / 5 ARG A 168
MET A 173
THR A 172
LEU A  61
 GTP  A1250 (-4.3A)
None
None
None
 1.21A 2eimJ-5a96A:
undetectable		 2eimJ-5a96A:
12.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIM_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 5a96 POLYHEDRIN
(Cypovirus
14) 		4 / 5 ARG A 168
MET A 173
THR A 172
LEU A  61
 GTP  A1250 (-4.3A)
None
None
None
 1.25A 2eimW-5a96A:
undetectable		 2eimW-5a96A:
12.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GL0_B_ADNB902_1
(CONSERVED
HYPOTHETICAL PROTEIN)		 5nd4 TUBULIN ALPHA CHAIN
(Bos
taurus) 		5 / 11 PHE A 169
HIS A   8
ASN A 228
ILE A 171
ALA A  19
 None
None
GTP  A 500 (-3.0A)
GTP  A 500 ( 4.7A)
None
 1.43A 2gl0B-5nd4A:
undetectable
2gl0C-5nd4A:
undetectable		 2gl0B-5nd4A:
17.35
2gl0C-5nd4A:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_F_TACF3888_1
(ELONGATION FACTOR
EF-TU)		 5ck3 PUTATIVE SIGNAL
RECOGNITION PARTICLE
PROTEIN
SRX DOMAIN
(Chaetomium
thermophilum) 		4 / 7 SER B 107
SER A  12
VAL A  14
LEU B 115
 GTP  B 402 ( 2.3A)
None
None
None
 0.80A 2hdnE-5ck3B:
undetectable
2hdnF-5ck3B:
6.4
2hdnH-5ck3B:
6.6		 2hdnE-5ck3B:
9.31
2hdnF-5ck3B:
20.98
2hdnH-5ck3B:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_H_TACH4888_1
(ELONGATION FACTOR
EF-TU)		 5ck3 PUTATIVE SIGNAL
RECOGNITION PARTICLE
PROTEIN
SRX DOMAIN
(Chaetomium
thermophilum) 		4 / 7 SER A  12
VAL A  14
LEU B 115
SER B 107
 None
None
None
GTP  B 402 ( 2.3A)
 0.81A 2hdnF-5ck3A:
undetectable
2hdnG-5ck3A:
undetectable
2hdnH-5ck3A:
undetectable		 2hdnF-5ck3A:
21.36
2hdnG-5ck3A:
21.33
2hdnH-5ck3A:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HMY_B_SAMB328_0
(PROTEIN
(CYTOSINE-SPECIFIC
METHYLTRANSFERASE
HHAI))		 3ldu PUTATIVE METHYLASE
(Clostridioides
difficile) 		5 / 12 GLY A 202
ASP A 263
ASP A 289
PRO A 307
LEU A 321
 GTP  A 383 (-2.6A)
None
GTP  A 383 ( 3.8A)
GTP  A 383 (-3.7A)
None
 0.92A 2hmyB-3lduA:
6.2		 2hmyB-3lduA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NXE_A_SAMA302_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 3ldu PUTATIVE METHYLASE
(Clostridioides
difficile) 		6 / 12 ASP A 198
GLY A 202
ILE A 262
ASP A 263
ASN A 305
LEU A 321
 None
GTP  A 383 (-2.6A)
GTP  A 383 (-4.2A)
None
GTP  A 383 (-4.2A)
None
 0.89A 2nxeA-3lduA:
10.6		 2nxeA-3lduA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NXE_B_SAMB303_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 3ldu PUTATIVE METHYLASE
(Clostridioides
difficile) 		5 / 12 ASP A 198
GLY A 202
ILE A 262
ASP A 263
ASN A 305
 None
GTP  A 383 (-2.6A)
GTP  A 383 (-4.2A)
None
GTP  A 383 (-4.2A)
 0.83A 2nxeB-3lduA:
7.2		 2nxeB-3lduA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OKC_B_SAMB500_0
(TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN)		 5mjs TUBULIN ALPHA-1
CHAIN
(Schizosaccharomy
ces
pombe) 		5 / 12 ALA E 108
GLY E 110
GLY E 150
VAL E 114
ASN E 190
 None
None
GTP  E 500 (-3.2A)
None
None
 1.19A 2okcB-5mjsE:
3.3		 2okcB-5mjsE:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZ7_A_CA4A1_1
(ANDROGEN RECEPTOR)		 5w3f TUBULIN ALPHA-1
CHAIN
(Saccharomyces
cerevisiae) 		5 / 12 ASN A 187
LEU A 142
GLY A 143
VAL A   9
ALA A 100
 None
None
GTP  A 502 ( 4.3A)
None
GTP  A 502 ( 4.8A)
 1.18A 2oz7A-5w3fA:
undetectable		 2oz7A-5w3fA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZ7_A_CA4A1_2
(ANDROGEN RECEPTOR)		 5ck3 PUTATIVE SIGNAL
RECOGNITION PARTICLE
PROTEIN
(Chaetomium
thermophilum) 		4 / 6 LEU B 254
TRP B 339
MET B 325
LEU B 200
 GTP  B 402 (-4.5A)
None
None
None
 1.06A 2oz7A-5ck3B:
undetectable		 2oz7A-5ck3B:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PKM_A_ADNA501_1
(ADENOSINE KINASE)		 1w5e FTSZ
(Methanocaldococc
us
jannaschii) 		5 / 12 ALA A 140
GLY A 138
GLY A 136
ALA A  48
GLY A  99
 None
None
GTP  A 500 (-3.9A)
GTP  A 500 (-3.4A)
GTP  A 500 (-3.3A)
 0.82A 2pkmA-1w5eA:
6.3		 2pkmA-1w5eA:
23.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2RK8_A_PPFA3969_1
(PHOSPHOENOLPYRUVATE
CARBOXYKINASE,
CYTOSOLIC [GTP])		 4ox2 PHOSPHOENOLPYRUVATE
CARBOXYKINASE,
CYTOSOLIC [GTP]
(Rattus
norvegicus) 		7 / 8 ARG A  87
LYS A 243
LYS A 244
HIS A 264
SER A 286
ASP A 311
ARG A 405
 SPV  A 704 (-3.8A)
SPV  A 704 (-4.5A)
MN  A 701 ( 2.4A)
MN  A 701 (-3.4A)
SPV  A 704 ( 2.8A)
MN  A 701 (-2.5A)
GTP  A 703 ( 2.8A)
 0.33A 2rk8A-4ox2A:
61.0		 2rk8A-4ox2A:
99.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2RK8_B_PPFB3969_1
(PHOSPHOENOLPYRUVATE
CARBOXYKINASE,
CYTOSOLIC [GTP])		 4ox2 PHOSPHOENOLPYRUVATE
CARBOXYKINASE,
CYTOSOLIC [GTP]
(Rattus
norvegicus) 		7 / 7 ARG A  87
LYS A 243
LYS A 244
HIS A 264
SER A 286
ASP A 311
ARG A 405
 SPV  A 704 (-3.8A)
SPV  A 704 (-4.5A)
MN  A 701 ( 2.4A)
MN  A 701 (-3.4A)
SPV  A 704 ( 2.8A)
MN  A 701 (-2.5A)
GTP  A 703 ( 2.8A)
 0.36A 2rk8B-4ox2A:
61.9		 2rk8B-4ox2A:
99.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_A_DIFA1375_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 4jzt DGTP
PYROPHOSPHOHYDROLASE
(Bacillus
subtilis) 		3 / 3 LEU A  14
TYR A  86
GLN A  85
 None
GTP  A 201 (-4.8A)
None
 0.75A 2wekA-4jztA:
undetectable		 2wekA-4jztA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XCT_H_CPFH1020_1
(DNA GYRASE SUBUNIT
B, DNA GYRASE
SUBUNIT A)		 2ywg GTP-BINDING PROTEIN
LEPA
(Aquifex
aeolicus) 		3 / 3 ARG A 356
GLU A 360
SER A  20
 None
None
GTP  A 701 (-2.6A)
 0.84A 2xctD-2ywgA:
4.4		 2xctD-2ywgA:
23.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YVL_D_SAMD603_0
(HYPOTHETICAL PROTEIN)		 1z0k GTP-BINDING PROTEIN
(Homo
sapiens) 		5 / 12 GLY A  66
GLY A  15
ALA A  98
VAL A  13
PHE A  70
 GTP  A1200 (-3.5A)
None
None
None
None
 1.18A 2yvlD-1z0kA:
undetectable		 2yvlD-1z0kA:
24.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZIF_A_SAMA298_0
(PUTATIVE
MODIFICATION
METHYLASE)		 3ldu PUTATIVE METHYLASE
(Clostridioides
difficile) 		5 / 12 ALA A 290
PRO A 307
PRO A 175
GLY A 202
THR A 205
 GTP  A 383 (-3.7A)
GTP  A 383 (-3.7A)
GTP  A 383 (-4.3A)
GTP  A 383 (-2.6A)
GTP  A 383 (-3.5A)
 0.58A 2zifA-3lduA:
undetectable		 2zifA-3lduA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZVJ_A_SAMA301_1
(CATECHOL
O-METHYLTRANSFERASE)		 2wkp NPH1-1, RAS-RELATED
C3 BOTULINUM TOXIN
SUBSTRATE 1
(Avena
sativa;
Homo
sapiens) 		4 / 6 GLU A 699
TYR A 682
SER A 701
ASP A 664
 None
None
GTP  A1724 (-3.6A)
None
 1.35A 2zvjA-2wkpA:
undetectable		 2zvjA-2wkpA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZVJ_A_SAMA301_1
(CATECHOL
O-METHYLTRANSFERASE)		 5hzh RAS-RELATED C3
BOTULINUM TOXIN
SUBSTRATE
1,NPH1-1,RAS-RELATED
C3 BOTULINUM TOXIN
SUBSTRATE 1
(Avena
sativa;
Homo
sapiens) 		4 / 6 GLU A 305
TYR A 288
SER A 307
ASP A 270
 None
None
GTP  A 401 (-3.5A)
None
 1.38A 2zvjA-5hzhA:
undetectable		 2zvjA-5hzhA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG1_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1)		 5a96 POLYHEDRIN
(Cypovirus
14) 		4 / 5 ARG A 168
MET A 173
THR A 172
LEU A  61
 GTP  A1250 (-4.3A)
None
None
None
 1.27A 3ag1J-5a96A:
undetectable		 3ag1J-5a96A:
12.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG2_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1)		 5a96 POLYHEDRIN
(Cypovirus
14) 		4 / 5 ARG A 168
MET A 173
THR A 172
LEU A  61
 GTP  A1250 (-4.3A)
None
None
None
 1.22A 3ag2J-5a96A:
undetectable		 3ag2J-5a96A:
12.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG4_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1)		 5a96 POLYHEDRIN
(Cypovirus
14) 		4 / 5 ARG A 168
MET A 173
THR A 172
LEU A  61
 GTP  A1250 (-4.3A)
None
None
None
 1.34A 3ag4J-5a96A:
undetectable		 3ag4J-5a96A:
12.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BF1_D_PAUD248_0
(TYPE III
PANTOTHENATE KINASE)		 3cnn PUTATIVE
UNCHARACTERIZED
PROTEIN
(Thermotoga
maritima) 		5 / 11 LEU A  90
THR A  81
GLY A  84
THR A 114
ILE A 115
 None
None
None
GTP  A 263 (-3.5A)
None
 1.28A 3bf1C-3cnnA:
undetectable
3bf1D-3cnnA:
undetectable		 3bf1C-3cnnA:
22.26
3bf1D-3cnnA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJ8_C_SPMC500_1
(DIAMINE
ACETYLTRANSFERASE 1)		 2qv6 GTP CYCLOHYDROLASE
III
(Methanocaldococc
us
jannaschii) 		4 / 6 LEU A 166
ASP A 138
LEU A 233
HIS A 136
 None
CA  A 302 (-2.1A)
None
GTP  A 300 (-4.7A)
 1.21A 3bj8C-2qv6A:
undetectable
3bj8D-2qv6A:
undetectable		 3bj8C-2qv6A:
22.22
3bj8D-2qv6A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_C_DVAC59_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 1w5e FTSZ
(Methanocaldococc
us
jannaschii) 		3 / 3 GLY A  99
GLY A 136
GLY A 133
 GTP  A 500 (-3.3A)
GTP  A 500 (-3.9A)
GTP  A 500 (-2.9A)
 0.40A 3bogC-1w5eA:
undetectable		 3bogC-1w5eA:
14.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_D_DVAD10_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 5ucy TUBULIN ALPHA CHAIN
(Tetrahymena
thermophila) 		3 / 3 GLY A 143
GLY A  13
GLY A  10
 GTP  A 501 (-1.5A)
None
GTP  A 501 (-2.2A)
 0.37A 3bogD-5ucyA:
undetectable		 3bogD-5ucyA:
8.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CB8_A_SAMA501_0
(PYRUVATE
FORMATE-LYASE
1-ACTIVATING ENZYME)		 4o2l GTP-BINDING PROTEIN
RHEB
(Mus
musculus) 		5 / 12 SER A  68
LYS A  19
ARG A  15
VAL A  17
TYR A  85
 None
GTP  A 201 ( 2.6A)
None
GTP  A 201 (-4.1A)
None
 1.38A 3cb8A-4o2lA:
1.9		 3cb8A-4o2lA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CJT_C_SAMC302_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 3ldu PUTATIVE METHYLASE
(Clostridioides
difficile) 		5 / 12 ASP A 198
ASP A 261
ILE A 262
ASP A 263
LEU A 321
 None
GTP  A 383 (-3.0A)
GTP  A 383 (-4.2A)
None
None
 0.59A 3cjtC-3lduA:
10.6		 3cjtC-3lduA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_A_D2VA602_1
(CYTOCHROME P450 2R1)		 1w5e FTSZ
(Methanocaldococc
us
jannaschii) 		5 / 12 THR A 135
VAL A  67
VAL A 125
ILE A 127
THR A  41
 GTP  A 500 (-3.6A)
None
None
None
None
 1.14A 3czhA-1w5eA:
undetectable		 3czhA-1w5eA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_A_D2VA602_2
(CYTOCHROME P450 2R1)		 4fwt ELONGATION FACTOR
TS, ELONGATION
FACTOR TU, LINKER, Q
BETA REPLICASE
(Escherichia
coli;
Escherichia
virus
Qbeta) 		3 / 3 LEU A 934
GLU A1026
ILE A1029
 None
GTP  A2501 (-2.5A)
None
 0.56A 3czhA-4fwtA:
undetectable		 3czhA-4fwtA:
15.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D41_A_FCNA4001_1
(FOMA PROTEIN)		 5mjs TUBULIN ALPHA-1
CHAIN
(Schizosaccharomy
ces
pombe) 		4 / 8 GLY E 146
GLY E 147
GLY E 150
THR E 194
 GTP  E 500 (-3.4A)
GTP  E 500 (-3.1A)
GTP  E 500 (-3.2A)
None
 0.65A 3d41A-5mjsE:
undetectable		 3d41A-5mjsE:
15.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DH0_B_SAMB300_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 2v4y URIDYLATE KINASE
(Escherichia
coli) 		5 / 12 LEU A  21
GLY A  56
GLY A  18
ALA A  83
THR A  84
 None
GTP  A1243 (-3.3A)
GTP  A1243 (-3.5A)
None
None
 1.14A 3dh0B-2v4yA:
undetectable		 3dh0B-2v4yA:
24.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E9R_A_ACTA700_0
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 5ucy TUBULIN ALPHA CHAIN
(Tetrahymena
thermophila) 		4 / 6 GLY A 144
GLU A  71
GLY A  10
ASN A 101
 GTP  A 501 (-2.2A)
GTP  A 501 ( 1.8A)
GTP  A 501 (-2.2A)
GTP  A 501 (-3.3A)
 0.79A 3e9rA-5ucyA:
undetectable		 3e9rA-5ucyA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E9R_C_ACTC700_0
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 5ucy TUBULIN ALPHA CHAIN
(Tetrahymena
thermophila) 		4 / 6 GLY A 144
GLU A  71
GLY A  10
ASN A 101
 GTP  A 501 (-2.2A)
GTP  A 501 ( 1.8A)
GTP  A 501 (-2.2A)
GTP  A 501 (-3.3A)
 0.78A 3e9rC-5ucyA:
undetectable		 3e9rC-5ucyA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_B_CHDB150_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 5w3f TUBULIN ALPHA-1
CHAIN
(Saccharomyces
cerevisiae) 		5 / 12 PHE A 138
ILE A   7
ASN A 103
LEU A 190
THR A 191
 None
None
GTP  A 502 (-3.4A)
None
None
 1.38A 3em0B-5w3fA:
undetectable		 3em0B-5w3fA:
14.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3F8W_A_ADNA300_1
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 5ucy TUBULIN ALPHA CHAIN
(Tetrahymena
thermophila) 		5 / 12 TYR A 224
GLY A 144
GLU A  71
GLY A  10
ASN A 101
 GTP  A 501 (-1.0A)
GTP  A 501 (-2.2A)
GTP  A 501 ( 1.8A)
GTP  A 501 (-2.2A)
GTP  A 501 (-3.3A)
 0.95A 3f8wA-5ucyA:
undetectable		 3f8wA-5ucyA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3F8W_B_ADNB301_1
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 5ucy TUBULIN ALPHA CHAIN
(Tetrahymena
thermophila) 		5 / 12 TYR A 224
GLY A 144
GLU A  71
GLY A  10
ASN A 101
 GTP  A 501 (-1.0A)
GTP  A 501 (-2.2A)
GTP  A 501 ( 1.8A)
GTP  A 501 (-2.2A)
GTP  A 501 (-3.3A)
 0.97A 3f8wB-5ucyA:
undetectable		 3f8wB-5ucyA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3F8W_C_ADNC302_1
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 5ucy TUBULIN ALPHA CHAIN
(Tetrahymena
thermophila) 		5 / 12 TYR A 224
GLY A 144
GLU A  71
GLY A  10
ASN A 101
 GTP  A 501 (-1.0A)
GTP  A 501 (-2.2A)
GTP  A 501 ( 1.8A)
GTP  A 501 (-2.2A)
GTP  A 501 (-3.3A)
 0.95A 3f8wC-5ucyA:
undetectable		 3f8wC-5ucyA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G88_A_SAMA303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 1z0k GTP-BINDING PROTEIN
(Homo
sapiens) 		5 / 11 GLY A  15
GLY A  66
THR A  74
ALA A  84
ALA A  98
 None
GTP  A1200 (-3.5A)
None
None
None
 1.10A 3g88A-1z0kA:
2.1		 3g88A-1z0kA:
24.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G88_B_SAMB303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 1z0k GTP-BINDING PROTEIN
(Homo
sapiens) 		5 / 11 GLY A  15
GLY A  66
THR A  74
ALA A  84
ALA A  98
 None
GTP  A1200 (-3.5A)
None
None
None
 1.09A 3g88B-1z0kA:
2.3		 3g88B-1z0kA:
24.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8B_B_SAMB303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 1z0k GTP-BINDING PROTEIN
(Homo
sapiens) 		5 / 12 GLY A  15
GLY A  66
THR A  74
ALA A  84
ALA A  98
 None
GTP  A1200 (-3.5A)
None
None
None
 1.08A 3g8bB-1z0kA:
undetectable		 3g8bB-1z0kA:
24.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GLQ_A_RABA602_2
(ADENOSYLHOMOCYSTEINA
SE)		 4ncn EUKARYOTIC
TRANSLATION
INITIATION FACTOR
5B-LIKE PROTEIN
(Chaetomium
thermophilum) 		4 / 5 GLN A 549
THR A 557
GLU A 804
THR A 563
 GTP  A1001 (-3.8A)
MG  A1002 ( 3.0A)
None
None
 1.37A 3glqA-4ncnA:
4.1		 3glqA-4ncnA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_A_SAMA301_0
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 3cnn PUTATIVE
UNCHARACTERIZED
PROTEIN
(Thermotoga
maritima) 		5 / 12 ASN A  54
THR A  24
ILE A  79
THR A  81
LEU A  94
 GTP  A 263 (-3.7A)
None
None
None
None
 1.11A 3iv6A-3cnnA:
undetectable		 3iv6A-3cnnA:
23.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_B_SAMB301_0
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 4mit RHO FAMILY GTPASE
(Entamoeba
histolytica) 		5 / 12 PHE A  35
THR A 168
PHE A 176
ILE A 162
ASP A 125
 GTP  A 201 (-4.4A)
None
None
None
GTP  A 201 (-2.9A)
 1.04A 3iv6B-4mitA:
undetectable		 3iv6B-4mitA:
24.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IXL_A_PACA5000_0
(ARYLMALONATE
DECARBOXYLASE)		 5nd4 TUBULIN ALPHA CHAIN
(Bos
taurus) 		5 / 10 THR A 150
SER A 151
SER A 147
GLY A 146
GLY A 143
 None
None
None
GTP  A 500 ( 4.4A)
GTP  A 500 (-3.0A)
 1.41A 3ixlA-5nd4A:
2.0		 3ixlA-5nd4A:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IXL_A_PACA5000_0
(ARYLMALONATE
DECARBOXYLASE)		 5nd4 TUBULIN ALPHA CHAIN
(Bos
taurus) 		5 / 10 THR A 150
SER A 151
SER A 147
GLY A 146
GLY A 144
 None
None
None
GTP  A 500 ( 4.4A)
GTP  A 500 (-2.9A)
 1.08A 3ixlA-5nd4A:
2.0		 3ixlA-5nd4A:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J7Z_A_ERYA9000_0
(23S RRNA
50S RIBOSOMAL
PROTEIN L22
ERMCL NASCENT CHAIN)		 1ckm MRNA CAPPING ENZYME
(Paramecium
bursaria
Chlorella
virus
1) 		3 / 3 LYS A 234
ILE A 256
PHE A 257
 GTP  A 899 (-2.6A)
None
None
 0.97A 3j7zS-1ckmA:
0.0
3j7za-1ckmA:
undetectable		 3j7zS-1ckmA:
17.48
3j7za-1ckmA:
5.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JAY_A_SAMA1102_1
(STRUCTURAL PROTEIN
VP3)		 5xox TRNA(HIS)
GUANYLYLTRANSFERASE
(Saccharomyces
cerevisiae) 		3 / 3 ARG A 133
ASP A  77
ASP A 131
 None
GTP  A 301 (-2.4A)
None
 0.67A 3jayA-5xoxA:
undetectable		 3jayA-5xoxA:
12.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB2_A_SAMA1102_1
(STRUCTURAL PROTEIN
VP3)		 5xox TRNA(HIS)
GUANYLYLTRANSFERASE
(Saccharomyces
cerevisiae) 		3 / 3 ARG A 133
ASP A  77
ASP A 131
 None
GTP  A 301 (-2.4A)
None
 0.70A 3jb2A-5xoxA:
undetectable		 3jb2A-5xoxA:
12.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB3_A_SAMA1102_1
(STRUCTURAL PROTEIN
VP3)		 5xox TRNA(HIS)
GUANYLYLTRANSFERASE
(Saccharomyces
cerevisiae) 		3 / 3 ARG A 133
ASP A  77
ASP A 131
 None
GTP  A 301 (-2.4A)
None
 0.64A 3jb3A-5xoxA:
undetectable		 3jb3A-5xoxA:
12.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPB_A_SAMA1000_0
(UNCHARACTERIZED
PROTEIN MJ0100)		 5x8o INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Trypanosoma
brucei) 		5 / 12 ASN A 193
ILE A  99
THR A 208
ASP A 211
LYS A 214
 None
GTP  A 601 ( 4.2A)
GTP  A 601 (-3.9A)
GTP  A 601 (-2.8A)
GTP  A 601 (-3.0A)
 1.10A 3kpbA-5x8oA:
15.3		 3kpbA-5x8oA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_A_PZIA800_0
(GLUTAMATE RECEPTOR 2)		 1wdt ELONGATION FACTOR G
HOMOLOG
(Thermus
thermophilus) 		4 / 7 TYR A 164
LEU A 136
ASP A 137
SER A 254
 None
None
GTP  A 700 (-2.8A)
GTP  A 700 (-2.5A)
 1.36A 3lslA-1wdtA:
undetectable
3lslD-1wdtA:
undetectable		 3lslA-1wdtA:
16.52
3lslD-1wdtA:
16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_D_PZID800_0
(GLUTAMATE RECEPTOR 2)		 1wdt ELONGATION FACTOR G
HOMOLOG
(Thermus
thermophilus) 		4 / 7 SER A 254
TYR A 164
LEU A 136
ASP A 137
 GTP  A 700 (-2.5A)
None
None
GTP  A 700 (-2.8A)
 1.34A 3lslA-1wdtA:
undetectable
3lslD-1wdtA:
undetectable		 3lslA-1wdtA:
16.52
3lslD-1wdtA:
16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MNO_A_DEXA784_1
(GLUCOCORTICOID
RECEPTOR)		 2wkp NPH1-1, RAS-RELATED
C3 BOTULINUM TOXIN
SUBSTRATE 1
(Avena
sativa;
Homo
sapiens) 		5 / 12 GLY A 555
VAL A 551
LEU A 563
CYH A 561
ILE A 576
 GTP  A1724 (-3.6A)
None
None
GTP  A1724 (-3.4A)
None
 1.37A 3mnoA-2wkpA:
undetectable		 3mnoA-2wkpA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MNO_A_DEXA784_1
(GLUCOCORTICOID
RECEPTOR)		 4mit RHO FAMILY GTPASE
(Entamoeba
histolytica) 		5 / 12 GLY A  19
VAL A  15
LEU A  27
CYH A  25
ILE A  40
 GTP  A 201 (-3.5A)
None
None
GTP  A 201 (-3.2A)
None
 1.37A 3mnoA-4mitA:
undetectable		 3mnoA-4mitA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MNO_A_DEXA784_1
(GLUCOCORTICOID
RECEPTOR)		 5hzh RAS-RELATED C3
BOTULINUM TOXIN
SUBSTRATE
1,NPH1-1,RAS-RELATED
C3 BOTULINUM TOXIN
SUBSTRATE 1
(Avena
sativa;
Homo
sapiens) 		5 / 12 GLY A  12
VAL A   8
LEU A  20
CYH A  18
ILE A  33
 GTP  A 401 (-3.5A)
None
None
GTP  A 401 (-3.4A)
None
 1.33A 3mnoA-5hzhA:
undetectable		 3mnoA-5hzhA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MNP_A_DEXA784_1
(GLUCOCORTICOID
RECEPTOR)		 2wkp NPH1-1, RAS-RELATED
C3 BOTULINUM TOXIN
SUBSTRATE 1
(Avena
sativa;
Homo
sapiens) 		5 / 12 GLY A 555
VAL A 551
LEU A 563
CYH A 561
ILE A 576
 GTP  A1724 (-3.6A)
None
None
GTP  A1724 (-3.4A)
None
 1.36A 3mnpA-2wkpA:
undetectable		 3mnpA-2wkpA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MNP_A_DEXA784_1
(GLUCOCORTICOID
RECEPTOR)		 4mit RHO FAMILY GTPASE
(Entamoeba
histolytica) 		5 / 12 GLY A  19
VAL A  15
LEU A  27
CYH A  25
ILE A  40
 GTP  A 201 (-3.5A)
None
None
GTP  A 201 (-3.2A)
None
 1.37A 3mnpA-4mitA:
undetectable		 3mnpA-4mitA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MNP_A_DEXA784_1
(GLUCOCORTICOID
RECEPTOR)		 5hzh RAS-RELATED C3
BOTULINUM TOXIN
SUBSTRATE
1,NPH1-1,RAS-RELATED
C3 BOTULINUM TOXIN
SUBSTRATE 1
(Avena
sativa;
Homo
sapiens) 		5 / 12 GLY A  12
VAL A   8
LEU A  20
CYH A  18
ILE A  33
 GTP  A 401 (-3.5A)
None
None
GTP  A 401 (-3.4A)
None
 1.32A 3mnpA-5hzhA:
undetectable		 3mnpA-5hzhA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N58_A_ADNA500_2
(ADENOSYLHOMOCYSTEINA
SE)		 4ncn EUKARYOTIC
TRANSLATION
INITIATION FACTOR
5B-LIKE PROTEIN
(Chaetomium
thermophilum) 		4 / 5 GLN A 549
THR A 557
GLU A 804
THR A 563
 GTP  A1001 (-3.8A)
MG  A1002 ( 3.0A)
None
None
 1.44A 3n58A-4ncnA:
undetectable		 3n58A-4ncnA:
24.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N62_B_MTLB870_0
(NITRIC OXIDE
SYNTHASE)		 5w3f TUBULIN ALPHA-1
CHAIN
(Saccharomyces
cerevisiae) 		4 / 8 SER A 224
GLN A  15
PHE A 225
ASN A 227
 None
None
GTP  A 502 (-3.8A)
None
 1.09A 3n62B-5w3fA:
undetectable		 3n62B-5w3fA:
23.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N66_B_MTLB870_0
(NITRIC OXIDE
SYNTHASE)		 5w3f TUBULIN ALPHA-1
CHAIN
(Saccharomyces
cerevisiae) 		4 / 8 SER A 224
GLN A  15
PHE A 225
ASN A 227
 None
None
GTP  A 502 (-3.8A)
None
 1.11A 3n66B-5w3fA:
0.7		 3n66B-5w3fA:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ONN_A_ACTA271_0
(PROTEIN SSM1)		 1w5e FTSZ
(Methanocaldococc
us
jannaschii) 		4 / 5 GLY A 132
GLU A 165
GLY A 130
PRO A 161
 GTP  A 500 ( 4.0A)
GTP  A 500 (-3.1A)
GTP  A 500 (-3.5A)
GTP  A 500 ( 4.5A)
 1.03A 3onnA-1w5eA:
6.0		 3onnA-1w5eA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ONN_A_ACTA271_0
(PROTEIN SSM1)		 5mn5 CELL DIVISION
PROTEIN FTSZ
(Staphylococcus
aureus) 		4 / 5 GLY A 106
GLU A 139
GLY A 104
PRO A 135
 GTP  A 401 ( 4.1A)
GTP  A 401 (-2.6A)
GTP  A 401 (-3.4A)
GTP  A 401 (-4.1A)
 1.02A 3onnA-5mn5A:
6.9		 3onnA-5mn5A:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q87_B_SAMB300_0
(N6 ADENINE SPECIFIC
DNA METHYLASE)		 3ldu PUTATIVE METHYLASE
(Clostridioides
difficile) 		5 / 12 ILE A 206
ASP A 261
ASP A 289
ASN A 305
PRO A 307
 None
GTP  A 383 (-3.0A)
GTP  A 383 ( 3.8A)
GTP  A 383 (-4.2A)
GTP  A 383 (-3.7A)
 0.88A 3q87B-3lduA:
10.5		 3q87B-3lduA:
16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S53_A_017A201_2
(PROTEASE)		 2qv6 GTP CYCLOHYDROLASE
III
(Methanocaldococc
us
jannaschii) 		5 / 11 LEU A 212
ILE A 142
GLY A 181
ILE A 180
ILE A 139
 None
GTP  A 300 (-4.1A)
GTP  A 300 ( 4.8A)
GTP  A 300 (-3.8A)
None
 1.00A 3s53B-2qv6A:
undetectable		 3s53B-2qv6A:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S79_A_ASDA601_1
(CYTOCHROME P450 19A1)		 2v4y URIDYLATE KINASE
(Escherichia
coli) 		5 / 12 ALA A 148
THR A 145
LEU A  21
MET A  91
LEU A  16
 None
GTP  A1243 (-4.5A)
None
None
None
 1.25A 3s79A-2v4yA:
undetectable		 3s79A-2v4yA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SDV_A_911A822_0
(ALPHA-BISABOLENE
SYNTHASE)		 5xox TRNA(HIS)
GUANYLYLTRANSFERASE
(Saccharomyces
cerevisiae) 		4 / 4 ASP A  29
ASP A  77
ARG A 150
ASP A 153
 MG  A 303 (-3.0A)
GTP  A 301 (-2.4A)
None
None
 1.50A 3sdvA-5xoxA:
undetectable		 3sdvA-5xoxA:
15.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SFU_A_RBVA601_1
(RNA POLYMERASE)		 5xe0 GENOME POLYPROTEIN
(Enterovirus
D) 		6 / 9 ASP A 234
ASN A 293
TYR A 322
GLY A 323
ASP A 324
ASP A 325
 GTP  A 501 (-2.6A)
None
None
None
GTP  A 501 ( 4.2A)
None
 0.64A 3sfuA-5xe0A:
31.4		 3sfuA-5xe0A:
27.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SFU_A_RBVA601_1
(RNA POLYMERASE)		 5xe0 GENOME POLYPROTEIN
(Enterovirus
D) 		5 / 9 SER A 284
ASN A 293
TYR A 322
ASP A 324
ASP A 325
 GTP  A 501 (-4.0A)
None
None
GTP  A 501 ( 4.2A)
None
 1.06A 3sfuA-5xe0A:
31.4		 3sfuA-5xe0A:
27.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SFU_A_RBVA601_1
(RNA POLYMERASE)		 5xe0 GENOME POLYPROTEIN
(Enterovirus
D) 		5 / 9 SER A 284
THR A 289
TYR A 322
ASP A 324
ASP A 325
 GTP  A 501 (-4.0A)
None
None
GTP  A 501 ( 4.2A)
None
 1.06A 3sfuA-5xe0A:
31.4		 3sfuA-5xe0A:
27.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SFU_A_RBVA601_1
(RNA POLYMERASE)		 5xe0 GENOME POLYPROTEIN
(Enterovirus
D) 		5 / 9 THR A 289
TYR A 322
GLY A 323
ASP A 324
ASP A 325
 None
None
None
GTP  A 501 ( 4.2A)
None
 0.61A 3sfuA-5xe0A:
31.4		 3sfuA-5xe0A:
27.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SFU_B_RBVB601_1
(RNA POLYMERASE)		 5xe0 GENOME POLYPROTEIN
(Enterovirus
D) 		7 / 9 ASP A 234
ASN A 293
TYR A 322
GLY A 323
ASP A 324
ASP A 325
LEU A 370
 GTP  A 501 (-2.6A)
None
None
None
GTP  A 501 ( 4.2A)
None
None
 0.63A 3sfuB-5xe0A:
31.3		 3sfuB-5xe0A:
27.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SFU_C_RBVC601_1
(RNA POLYMERASE)		 5xe0 GENOME POLYPROTEIN
(Enterovirus
D) 		6 / 11 LYS A 155
ARG A 170
ASP A 234
ASN A 293
GLY A 323
ASP A 324
 GTP  A 501 (-4.8A)
GTP  A 501 (-3.7A)
GTP  A 501 (-2.6A)
None
None
GTP  A 501 ( 4.2A)
 0.87A 3sfuC-5xe0A:
31.4		 3sfuC-5xe0A:
27.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SFU_C_RBVC601_1
(RNA POLYMERASE)		 5xe0 GENOME POLYPROTEIN
(Enterovirus
D) 		5 / 11 LYS A 155
ASP A 234
THR A 289
GLY A 323
ASP A 324
 GTP  A 501 (-4.8A)
GTP  A 501 (-2.6A)
None
None
GTP  A 501 ( 4.2A)
 0.87A 3sfuC-5xe0A:
31.4		 3sfuC-5xe0A:
27.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_B_ACTB4_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 1yhn RAS-RELATED PROTEIN
RAB-7
(Homo
sapiens) 		3 / 3 GLY A  18
GLY A  20
THR A  22
 GTP  A 301 (-2.6A)
GTP  A 301 (-2.9A)
MG  A 302 ( 3.3A)
 0.41A 3si7B-1yhnA:
undetectable		 3si7B-1yhnA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TM4_A_SAMA401_0
(TRNA (GUANINE
N2-)-METHYLTRANSFERA
SE TRM14)		 3ldu PUTATIVE METHYLASE
(Clostridioides
difficile) 		6 / 12 MET A 200
GLY A 202
ALA A 290
ASN A 305
PRO A 307
LEU A 321
 GTP  A 383 (-4.5A)
GTP  A 383 (-2.6A)
GTP  A 383 (-3.7A)
GTP  A 383 (-4.2A)
GTP  A 383 (-3.7A)
None
 0.60A 3tm4A-3lduA:
33.1		 3tm4A-3lduA:
28.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TM4_B_SAMB401_0
(TRNA (GUANINE
N2-)-METHYLTRANSFERA
SE TRM14)		 3ldu PUTATIVE METHYLASE
(Clostridioides
difficile) 		5 / 12 ALA A 174
GLY A 202
ALA A 290
ASN A 305
LEU A 321
 GTP  A 383 (-4.7A)
GTP  A 383 (-2.6A)
GTP  A 383 (-3.7A)
GTP  A 383 (-4.2A)
None
 0.88A 3tm4B-3lduA:
33.3		 3tm4B-3lduA:
28.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TM4_B_SAMB401_0
(TRNA (GUANINE
N2-)-METHYLTRANSFERA
SE TRM14)		 3ldu PUTATIVE METHYLASE
(Clostridioides
difficile) 		6 / 12 MET A 200
GLY A 202
ALA A 290
ASN A 305
PRO A 307
LEU A 321
 GTP  A 383 (-4.5A)
GTP  A 383 (-2.6A)
GTP  A 383 (-3.7A)
GTP  A 383 (-4.2A)
GTP  A 383 (-3.7A)
None
 0.62A 3tm4B-3lduA:
33.3		 3tm4B-3lduA:
28.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UR0_B_SVRB516_1
(RNA-DEPENDENT RNA
POLYMERASE)		 5ck3 PUTATIVE SIGNAL
RECOGNITION PARTICLE
PROTEIN
(Chaetomium
thermophilum) 		4 / 7 PRO B  58
GLY B  60
ALA B  61
ALA B 202
 None
GTP  B 402 (-3.9A)
GTP  B 402 (-4.1A)
None
 0.85A 3ur0B-5ck3B:
undetectable		 3ur0B-5ck3B:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UR0_B_SVRB516_1
(RNA-DEPENDENT RNA
POLYMERASE)		 5ck3 PUTATIVE SIGNAL
RECOGNITION PARTICLE
PROTEIN
(Chaetomium
thermophilum) 		4 / 7 PRO B  58
GLY B  60
ALA B  61
ALA B 203
 None
GTP  B 402 (-3.9A)
GTP  B 402 (-4.1A)
None
 0.57A 3ur0B-5ck3B:
undetectable		 3ur0B-5ck3B:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_E_ACTE502_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 2qag SEPTIN-2
SEPTIN-6
(Homo
sapiens;
Homo
sapiens) 		3 / 3 LYS B 185
ARG A 194
LEU A 187
 GTP  B 428 (-2.8A)
GTP  B 428 (-3.6A)
None
 1.18A 3v4tE-2qagB:
undetectable		 3v4tE-2qagB:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V8V_A_SAMA801_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE L)		 3ldu PUTATIVE METHYLASE
(Clostridioides
difficile) 		7 / 12 ILE A 176
MET A 200
GLY A 202
SER A 203
THR A 205
ASN A 305
LEU A 325
 GTP  A 383 (-3.8A)
GTP  A 383 (-4.5A)
GTP  A 383 (-2.6A)
GTP  A 383 (-2.7A)
GTP  A 383 (-3.5A)
GTP  A 383 (-4.2A)
None
 1.30A 3v8vA-3lduA:
41.6		 3v8vA-3lduA:
24.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V8V_A_SAMA801_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE L)		 3ldu PUTATIVE METHYLASE
(Clostridioides
difficile) 		9 / 12 ILE A 176
MET A 200
GLY A 202
SER A 203
THR A 205
ASP A 263
ASN A 305
PRO A 307
LEU A 321
 GTP  A 383 (-3.8A)
GTP  A 383 (-4.5A)
GTP  A 383 (-2.6A)
GTP  A 383 (-2.7A)
GTP  A 383 (-3.5A)
None
GTP  A 383 (-4.2A)
GTP  A 383 (-3.7A)
None
 0.66A 3v8vA-3lduA:
41.6		 3v8vA-3lduA:
24.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V8V_B_SAMB801_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE L)		 3ldu PUTATIVE METHYLASE
(Clostridioides
difficile) 		8 / 11 MET A 200
GLY A 202
ASP A 261
ASP A 263
ASP A 289
ASN A 305
PRO A 307
LEU A 321
 GTP  A 383 (-4.5A)
GTP  A 383 (-2.6A)
GTP  A 383 (-3.0A)
None
GTP  A 383 ( 3.8A)
GTP  A 383 (-4.2A)
GTP  A 383 (-3.7A)
None
 0.61A 3v8vB-3lduA:
37.4		 3v8vB-3lduA:
24.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V8V_B_SAMB801_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE L)		 3ldu PUTATIVE METHYLASE
(Clostridioides
difficile) 		6 / 11 MET A 200
GLY A 202
ASP A 261
ASP A 289
ASN A 305
LEU A 325
 GTP  A 383 (-4.5A)
GTP  A 383 (-2.6A)
GTP  A 383 (-3.0A)
GTP  A 383 ( 3.8A)
GTP  A 383 (-4.2A)
None
 1.16A 3v8vB-3lduA:
37.4		 3v8vB-3lduA:
24.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VN2_A_TLSA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3ffu PROBABLE
PYROPHOSPHOHYDROLASE
(Bdellovibrio
bacteriovorus) 		5 / 12 PHE A  52
HIS A  90
ILE A  97
LEU A  98
LEU A  84
 GTP  A4033 (-4.7A)
None
GTP  A4033 (-4.5A)
None
None
 1.39A 3vn2A-3ffuA:
undetectable		 3vn2A-3ffuA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VQR_A_ACTA1002_0
(PUTATIVE
OXIDOREDUCTASE)		 1yhn RAS-RELATED PROTEIN
RAB-7
(Homo
sapiens) 		4 / 6 ASP A  16
GLY A  18
VAL A  19
ASP A  89
 None
GTP  A 301 (-2.6A)
GTP  A 301 (-4.2A)
None
 1.06A 3vqrA-1yhnA:
undetectable		 3vqrA-1yhnA:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VQR_B_ACTB1002_0
(PUTATIVE
OXIDOREDUCTASE)		 1yhn RAS-RELATED PROTEIN
RAB-7
(Homo
sapiens) 		4 / 5 ASP A  16
GLY A  18
VAL A  19
ASP A  89
 None
GTP  A 301 (-2.6A)
GTP  A 301 (-4.2A)
None
 1.07A 3vqrB-1yhnA:
2.2		 3vqrB-1yhnA:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AX8_A_SAMA1474_0
(WBDD)		 4fme ADP-RIBOSYLATION
FACTOR 6
(Homo
sapiens) 		5 / 12 GLY C  25
ALA C  23
ILE C  29
VAL C  87
ILE C  85
 GTP  C 201 (-3.0A)
GTP  C 201 (-4.5A)
None
None
None
 0.89A 4ax8A-4fmeC:
undetectable		 4ax8A-4fmeC:
14.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AX8_A_SAMA1474_0
(WBDD)		 6bbp CYTOHESIN-3,ADP-RIBO
SYLATION FACTOR 6
(Homo
sapiens;
Mus
musculus) 		5 / 12 GLY A 423
ALA A 421
ILE A 427
VAL A 485
ILE A 483
 GTP  A 601 (-3.3A)
GTP  A 601 (-4.2A)
None
None
None
 0.83A 4ax8A-6bbpA:
3.0		 4ax8A-6bbpA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZS_A_SAMA1475_1
(METHYLTRANSFERASE
WBDD)		 1w5e FTSZ
(Methanocaldococc
us
jannaschii) 		3 / 3 ARG A 169
ASP A  72
GLN A  74
 GTP  A 500 (-3.5A)
None
None
 0.85A 4azsA-1w5eA:
2.9		 4azsA-1w5eA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZT_A_SAMA1472_0
(METHYLTRANSFERASE
WBDD)		 4fme ADP-RIBOSYLATION
FACTOR 6
(Homo
sapiens) 		5 / 12 GLY C  25
ALA C  23
ILE C  29
VAL C  87
ILE C  85
 GTP  C 201 (-3.0A)
GTP  C 201 (-4.5A)
None
None
None
 0.91A 4aztA-4fmeC:
undetectable		 4aztA-4fmeC:
14.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZT_A_SAMA1472_0
(METHYLTRANSFERASE
WBDD)		 6bbp CYTOHESIN-3,ADP-RIBO
SYLATION FACTOR 6
(Homo
sapiens;
Mus
musculus) 		5 / 12 GLY A 423
ALA A 421
ILE A 427
VAL A 485
ILE A 483
 GTP  A 601 (-3.3A)
GTP  A 601 (-4.2A)
None
None
None
 0.83A 4aztA-6bbpA:
undetectable		 4aztA-6bbpA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZV_A_SAMA1474_0
(WBDD)		 4fme ADP-RIBOSYLATION
FACTOR 6
(Homo
sapiens) 		5 / 12 GLY C  25
ALA C  23
ILE C  29
VAL C  87
ILE C  85
 GTP  C 201 (-3.0A)
GTP  C 201 (-4.5A)
None
None
None
 0.89A 4azvA-4fmeC:
undetectable		 4azvA-4fmeC:
14.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DCM_A_SAMA401_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE G)		 3ldu PUTATIVE METHYLASE
(Clostridioides
difficile) 		5 / 11 ASP A 198
GLY A 202
ILE A 206
ASP A 261
ASN A 305
 None
GTP  A 383 (-2.6A)
None
GTP  A 383 (-3.0A)
GTP  A 383 (-4.2A)
 0.76A 4dcmA-3lduA:
10.5		 4dcmA-3lduA:
23.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DCM_A_SAMA401_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE G)		 3ldu PUTATIVE METHYLASE
(Clostridioides
difficile) 		5 / 11 GLY A 202
ILE A 206
ASP A 261
ASN A 305
PRO A 307
 GTP  A 383 (-2.6A)
None
GTP  A 383 (-3.0A)
GTP  A 383 (-4.2A)
GTP  A 383 (-3.7A)
 0.54A 4dcmA-3lduA:
10.5		 4dcmA-3lduA:
23.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FE1_A_PQNA846_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 5ck3 PUTATIVE SIGNAL
RECOGNITION PARTICLE
PROTEIN
(Chaetomium
thermophilum) 		5 / 10 PHE B 310
SER B 307
LEU B 302
GLY B 303
ALA B  61
 None
None
None
None
GTP  B 402 (-4.1A)
 1.46A 4fe1A-5ck3B:
undetectable
4fe1J-5ck3B:
undetectable		 4fe1A-5ck3B:
19.10
4fe1J-5ck3B:
11.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FO4_A_MOAA502_1
(INOSINE
5'-MONOPHOSPHATE
DEHYDROGENASE)		 4hmy ADP-RIBOSYLATION
FACTOR 1
(Homo
sapiens) 		5 / 8 ASP C  96
ASN C  95
CYH C 159
THR C 161
GLY C  29
 None
None
GTP  C1001 ( 4.0A)
GTP  C1001 (-3.3A)
GTP  C1001 (-3.3A)
 1.37A 4fo4A-4hmyC:
undetectable		 4fo4A-4hmyC:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FR0_A_SAMA401_0
(ARSENIC
METHYLTRANSFERASE)		 5nd4 TUBULIN ALPHA CHAIN
(Bos
taurus) 		5 / 12 GLY A 106
GLY A 148
ILE A 110
GLU A  97
ASN A 101
 None
None
None
None
GTP  A 500 (-3.3A)
 1.12A 4fr0A-5nd4A:
3.2		 4fr0A-5nd4A:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HTF_A_SAMA301_0
(S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 5nd4 TUBULIN ALPHA CHAIN
(Bos
taurus) 		6 / 12 GLY A 146
GLY A 144
GLY A 143
SER A 187
VAL A   9
VAL A 137
 GTP  A 500 ( 4.4A)
GTP  A 500 (-2.9A)
GTP  A 500 (-3.0A)
None
None
None
 1.25A 4htfA-5nd4A:
3.3		 4htfA-5nd4A:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HTF_B_SAMB301_0
(S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 5nd4 TUBULIN ALPHA CHAIN
(Bos
taurus) 		6 / 12 GLY A 146
GLY A 144
GLY A 143
SER A 187
VAL A   9
VAL A 137
 GTP  A 500 ( 4.4A)
GTP  A 500 (-2.9A)
GTP  A 500 (-3.0A)
None
None
None
 1.29A 4htfB-5nd4A:
undetectable		 4htfB-5nd4A:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYT_C_OBNC2004_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 5mn5 CELL DIVISION
PROTEIN FTSZ
(Staphylococcus
aureus) 		5 / 12 GLY A 110
ALA A 113
LEU A  50
THR A  45
ILE A  61
 GTP  A 401 (-3.5A)
None
None
None
None
 1.21A 4hytC-5mn5A:
2.1		 4hytC-5mn5A:
16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JLG_A_SAMA401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 1w5e FTSZ
(Methanocaldococc
us
jannaschii) 		5 / 12 ILE A 251
ALA A 218
GLU A 213
GLY A  49
ASN A  51
 None
None
None
None
GTP  A 500 ( 4.2A)
 1.18A 4jlgA-1w5eA:
undetectable		 4jlgA-1w5eA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCN_B_MTLB806_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5w3f TUBULIN ALPHA-1
CHAIN
(Saccharomyces
cerevisiae) 		4 / 7 SER A 224
GLN A  15
PHE A 225
ASN A 227
 None
None
GTP  A 502 (-3.8A)
None
 1.19A 4kcnB-5w3fA:
undetectable		 4kcnB-5w3fA:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LRH_G_FOLG301_0
(FOLATE RECEPTOR
ALPHA)		 4ox2 PHOSPHOENOLPYRUVATE
CARBOXYKINASE,
CYTOSOLIC [GTP]
(Rattus
norvegicus) 		5 / 12 TYR A 235
ARG A 405
LYS A 243
GLY A 242
SER A 286
 None
GTP  A 703 ( 2.8A)
SPV  A 704 (-4.5A)
None
SPV  A 704 ( 2.8A)
 1.09A 4lrhG-4ox2A:
0.0		 4lrhG-4ox2A:
14.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MK4_A_CHDA503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5nd4 TUBULIN ALPHA CHAIN
(Bos
taurus) 		5 / 10 LEU A 153
LEU A 152
ARG A 123
LYS A 124
THR A 145
 None
None
None
None
GTP  A 500 (-4.0A)
 1.24A 4mk4A-5nd4A:
2.7		 4mk4A-5nd4A:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MV7_A_PPFA501_1
(BIOTIN CARBOXYLASE)		 4ncn EUKARYOTIC
TRANSLATION
INITIATION FACTOR
5B-LIKE PROTEIN
(Chaetomium
thermophilum) 		4 / 7 GLN A 549
VAL A 548
GLU A 552
ARG A 806
 GTP  A1001 (-3.8A)
None
MG  A1002 ( 4.0A)
None
 1.23A 4mv7A-4ncnA:
undetectable		 4mv7A-4ncnA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWV_A_BCZA513_0
(NEURAMINIDASE)		 3ffu PROBABLE
PYROPHOSPHOHYDROLASE
(Bdellovibrio
bacteriovorus) 		5 / 12 GLU A  74
LEU A  71
ILE A  99
GLU A  51
ARG A  40
 MG  A 156 (-2.3A)
None
GTP  A4033 ( 4.9A)
GTP  A4033 (-3.5A)
GTP  A4033 (-3.1A)
 1.30A 4mwvA-3ffuA:
undetectable		 4mwvA-3ffuA:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_D_STRD601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 2v4y URIDYLATE KINASE
(Escherichia
coli) 		5 / 12 ALA A 164
ASN A  87
GLY A  18
THR A 145
VAL A  53
 None
None
GTP  A1243 (-3.5A)
GTP  A1243 (-4.5A)
None
 1.10A 4nkxD-2v4yA:
undetectable		 4nkxD-2v4yA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1E_A_C2FA3000_0
(DIHYDROPTEROATE
SYNTHASE DHPS)		 5mjs TUBULIN ALPHA-1
CHAIN
(Schizosaccharomy
ces
pombe) 		6 / 12 ASN E 232
ILE E 235
ILE E  79
ASP E  73
GLY E  10
SER E 144
 GTP  E 500 (-3.3A)
None
None
GTP  E 500 (-3.6A)
GTP  E 500 (-3.1A)
GTP  E 500 (-3.5A)
 1.40A 4o1eA-5mjsE:
undetectable		 4o1eA-5mjsE:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OK1_A_198A1001_1
(ANDROGEN RECEPTOR)		 1w5e FTSZ
(Methanocaldococc
us
jannaschii) 		5 / 12 LEU A 131
GLY A 130
LEU A 215
VAL A 188
ILE A  53
 None
GTP  A 500 (-3.5A)
None
None
None
 1.15A 4ok1A-1w5eA:
0.0		 4ok1A-1w5eA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKB_A_198A1002_1
(ANDROGEN RECEPTOR)		 1w5e FTSZ
(Methanocaldococc
us
jannaschii) 		5 / 12 LEU A 131
GLY A 130
LEU A 215
VAL A 188
ILE A  53
 None
GTP  A 500 (-3.5A)
None
None
None
 1.19A 4okbA-1w5eA:
undetectable		 4okbA-1w5eA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OT2_A_ACTA605_0
(SERUM ALBUMIN)		 4ox2 PHOSPHOENOLPYRUVATE
CARBOXYKINASE,
CYTOSOLIC [GTP]
(Rattus
norvegicus) 		3 / 3 LYS A 244
LYS A 290
ALA A 481
 MN  A 701 ( 2.4A)
GTP  A 703 (-2.6A)
None
 1.47A 4ot2A-4ox2A:
2.9		 4ot2A-4ox2A:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PCL_A_SAMA301_0
(O-METHYLTRANSFERASE
FAMILY PROTEIN)		 5ck3 PUTATIVE SIGNAL
RECOGNITION PARTICLE
PROTEIN
(Chaetomium
thermophilum) 		5 / 12 ALA B 249
GLY B 335
ASP B 253
ALA B 336
TYR B 128
 None
None
GTP  B 402 (-3.3A)
None
None
 1.16A 4pclA-5ck3B:
2.2		 4pclA-5ck3B:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PST_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 6ewz GTP
PYROPHOSPHOKINASE
(Staphylococcus
aureus) 		3 / 3 ILE A 121
ASP A 141
ARG A 178
 None
None
GTP  A 301 ( 4.7A)
 0.81A 4pstA-6ewzA:
undetectable		 4pstA-6ewzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVL_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 1wdt ELONGATION FACTOR G
HOMOLOG
(Thermus
thermophilus) 		5 / 11 THR A  60
THR A  23
THR A  26
GLY A  83
ALA A  81
 GTP  A 700 (-3.6A)
MG  A 701 ( 3.3A)
None
GTP  A 700 (-3.1A)
None
 1.41A 4qvlV-1wdtA:
undetectable
4qvlb-1wdtA:
undetectable		 4qvlV-1wdtA:
15.26
4qvlb-1wdtA:
15.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVL_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 1wdt ELONGATION FACTOR G
HOMOLOG
(Thermus
thermophilus) 		5 / 11 THR A  60
THR A  23
THR A  26
GLY A  83
ALA A  81
 GTP  A 700 (-3.6A)
MG  A 701 ( 3.3A)
None
GTP  A 700 (-3.1A)
None
 1.41A 4qvlH-1wdtA:
undetectable
4qvlN-1wdtA:
undetectable		 4qvlH-1wdtA:
15.26
4qvlN-1wdtA:
15.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVM_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 1wdt ELONGATION FACTOR G
HOMOLOG
(Thermus
thermophilus) 		5 / 11 THR A  60
THR A  23
THR A  26
GLY A  83
ALA A  81
 GTP  A 700 (-3.6A)
MG  A 701 ( 3.3A)
None
GTP  A 700 (-3.1A)
None
 1.42A 4qvmV-1wdtA:
undetectable
4qvmb-1wdtA:
undetectable		 4qvmV-1wdtA:
15.26
4qvmb-1wdtA:
15.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVM_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 1wdt ELONGATION FACTOR G
HOMOLOG
(Thermus
thermophilus) 		5 / 11 THR A  60
THR A  23
THR A  26
GLY A  83
ALA A  81
 GTP  A 700 (-3.6A)
MG  A 701 ( 3.3A)
None
GTP  A 700 (-3.1A)
None
 1.42A 4qvmH-1wdtA:
undetectable
4qvmN-1wdtA:
undetectable		 4qvmH-1wdtA:
15.26
4qvmN-1wdtA:
15.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVW_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 1wdt ELONGATION FACTOR G
HOMOLOG
(Thermus
thermophilus) 		5 / 11 THR A  60
THR A  23
THR A  26
GLY A  83
ALA A  81
 GTP  A 700 (-3.6A)
MG  A 701 ( 3.3A)
None
GTP  A 700 (-3.1A)
None
 1.42A 4qvwV-1wdtA:
undetectable
4qvwb-1wdtA:
undetectable		 4qvwV-1wdtA:
15.26
4qvwb-1wdtA:
15.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVW_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 1wdt ELONGATION FACTOR G
HOMOLOG
(Thermus
thermophilus) 		5 / 11 THR A  60
THR A  23
THR A  26
GLY A  83
ALA A  81
 GTP  A 700 (-3.6A)
MG  A 701 ( 3.3A)
None
GTP  A 700 (-3.1A)
None
 1.42A 4qvwH-1wdtA:
undetectable
4qvwN-1wdtA:
undetectable		 4qvwH-1wdtA:
15.26
4qvwN-1wdtA:
15.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW0_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 1wdt ELONGATION FACTOR G
HOMOLOG
(Thermus
thermophilus) 		5 / 11 THR A  60
THR A  23
THR A  26
GLY A  83
ALA A  81
 GTP  A 700 (-3.6A)
MG  A 701 ( 3.3A)
None
GTP  A 700 (-3.1A)
None
 1.40A 4qw0V-1wdtA:
undetectable
4qw0b-1wdtA:
undetectable		 4qw0V-1wdtA:
15.26
4qw0b-1wdtA:
15.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW0_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 1wdt ELONGATION FACTOR G
HOMOLOG
(Thermus
thermophilus) 		5 / 11 THR A  60
THR A  23
THR A  26
GLY A  83
ALA A  81
 GTP  A 700 (-3.6A)
MG  A 701 ( 3.3A)
None
GTP  A 700 (-3.1A)
None
 1.40A 4qw0H-1wdtA:
undetectable
4qw0N-1wdtA:
undetectable		 4qw0H-1wdtA:
15.26
4qw0N-1wdtA:
15.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW3_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 1wdt ELONGATION FACTOR G
HOMOLOG
(Thermus
thermophilus) 		5 / 11 THR A  60
THR A  23
THR A  26
GLY A  83
ALA A  81
 GTP  A 700 (-3.6A)
MG  A 701 ( 3.3A)
None
GTP  A 700 (-3.1A)
None
 1.41A 4qw3V-1wdtA:
undetectable
4qw3b-1wdtA:
undetectable		 4qw3V-1wdtA:
15.26
4qw3b-1wdtA:
15.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW3_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 1wdt ELONGATION FACTOR G
HOMOLOG
(Thermus
thermophilus) 		5 / 11 THR A  60
THR A  23
THR A  26
GLY A  83
ALA A  81
 GTP  A 700 (-3.6A)
MG  A 701 ( 3.3A)
None
GTP  A 700 (-3.1A)
None
 1.41A 4qw3H-1wdtA:
undetectable
4qw3N-1wdtA:
undetectable		 4qw3H-1wdtA:
15.26
4qw3N-1wdtA:
15.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZU_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 2)		 1wdt ELONGATION FACTOR G
HOMOLOG
(Thermus
thermophilus) 		5 / 12 ILE A  91
THR A  47
THR A  49
VAL A  42
LEU A  14
 None
None
None
GTP  A 700 (-4.1A)
None
 1.40A 4qzuA-1wdtA:
undetectable		 4qzuA-1wdtA:
9.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R3A_B_RBFB402_1
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 2v4y URIDYLATE KINASE
(Escherichia
coli) 		5 / 10 GLU A  19
ASN A  59
LEU A  34
LEU A  16
MET A 220
 GTP  A1243 (-2.7A)
None
None
None
None
 1.38A 4r3aB-2v4yA:
undetectable		 4r3aB-2v4yA:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTS_A_SAMA301_0
(DNA ADENINE
METHYLASE)		 3ldu PUTATIVE METHYLASE
(Clostridioides
difficile) 		5 / 12 GLY A 202
ASP A 261
ILE A 262
PRO A 307
TYR A 308
 GTP  A 383 (-2.6A)
GTP  A 383 (-3.0A)
GTP  A 383 (-4.2A)
GTP  A 383 (-3.7A)
None
 0.59A 4rtsA-3lduA:
10.9		 4rtsA-3lduA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UW0_A_SAMA1506_0
(WBDD)		 4fme ADP-RIBOSYLATION
FACTOR 6
(Homo
sapiens) 		5 / 12 GLY C  25
ALA C  23
ILE C  29
VAL C  87
ILE C  85
 GTP  C 201 (-3.0A)
GTP  C 201 (-4.5A)
None
None
None
 0.98A 4uw0A-4fmeC:
2.3		 4uw0A-4fmeC:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UW0_A_SAMA1506_0
(WBDD)		 6bbp CYTOHESIN-3,ADP-RIBO
SYLATION FACTOR 6
(Homo
sapiens;
Mus
musculus) 		5 / 12 GLY A 423
ALA A 421
ILE A 427
VAL A 485
ILE A 483
 GTP  A 601 (-3.3A)
GTP  A 601 (-4.2A)
None
None
None
 0.93A 4uw0A-6bbpA:
2.3		 4uw0A-6bbpA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YMG_A_SAMA1001_0
(PUTATIVE
SAM-DEPENDENT
O-METHYLTRANFERASE)		 5nd4 TUBULIN ALPHA CHAIN
(Bos
taurus) 		5 / 12 GLY A 142
TYR A 185
SER A 170
ALA A  12
ASN A 206
 None
None
None
GTP  A 500 (-3.3A)
GTP  A 500 (-3.5A)
 1.41A 4ymgA-5nd4A:
4.2		 4ymgA-5nd4A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YMG_A_SAMA1001_0
(PUTATIVE
SAM-DEPENDENT
O-METHYLTRANFERASE)		 5xe0 GENOME POLYPROTEIN
(Enterovirus
D) 		5 / 12 GLY A 232
TYR A 230
GLU A 173
ALA A 235
TYR A  58
 GTP  A 501 (-3.6A)
None
None
None
None
 1.27A 4ymgA-5xe0A:
undetectable		 4ymgA-5xe0A:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZBQ_A_DIFA601_1
(SERUM ALBUMIN)		 2v4y URIDYLATE KINASE
(Escherichia
coli) 		5 / 11 LEU A  89
VAL A  85
LEU A  21
GLY A  56
LEU A  60
 None
None
None
GTP  A1243 (-3.3A)
None
 1.27A 4zbqA-2v4yA:
undetectable		 4zbqA-2v4yA:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AYF_A_SAMA401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 1w5e FTSZ
(Methanocaldococc
us
jannaschii) 		5 / 11 ILE A 251
ALA A 218
GLU A 213
GLY A  49
ASN A  51
 None
None
None
None
GTP  A 500 ( 4.2A)
 1.12A 5ayfA-1w5eA:
undetectable		 5ayfA-1w5eA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B6I_A_ADNA302_1
(FLUORINASE)		 5ck3 PUTATIVE SIGNAL
RECOGNITION PARTICLE
PROTEIN
(Chaetomium
thermophilum) 		4 / 7 ASP B 146
THR B 147
PRO B 110
SER B 107
 GTP  B 402 ( 4.7A)
None
None
GTP  B 402 ( 2.3A)
 1.19A 5b6iA-5ck3B:
undetectable		 5b6iA-5ck3B:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CPR_B_SAMB402_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 5xox TRNA(HIS)
GUANYLYLTRANSFERASE
(Saccharomyces
cerevisiae) 		3 / 3 HIS A  34
SER A  76
ASN A 161
 GTP  A 301 (-4.2A)
GTP  A 301 (-3.9A)
None
 0.83A 5cprB-5xoxA:
undetectable		 5cprB-5xoxA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CXV_A_0HKA501_2
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M1,ENDOLYSIN,MUSCARI
NIC ACETYLCHOLINE
RECEPTOR M1)		 5hzh RAS-RELATED C3
BOTULINUM TOXIN
SUBSTRATE
1,NPH1-1,RAS-RELATED
C3 BOTULINUM TOXIN
SUBSTRATE 1
(Avena
sativa;
Homo
sapiens) 		3 / 3 THR A  24
THR A  25
PHE A  28
 None
None
GTP  A 401 (-4.8A)
 0.89A 5cxvA-5hzhA:
undetectable		 5cxvA-5hzhA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CZ7_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 1wdt ELONGATION FACTOR G
HOMOLOG
(Thermus
thermophilus) 		5 / 11 THR A  60
THR A  23
THR A  26
GLY A  83
ALA A  81
 GTP  A 700 (-3.6A)
MG  A 701 ( 3.3A)
None
GTP  A 700 (-3.1A)
None
 1.41A 5cz7H-1wdtA:
undetectable
5cz7N-1wdtA:
undetectable		 5cz7H-1wdtA:
15.26
5cz7N-1wdtA:
15.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0X_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 1wdt ELONGATION FACTOR G
HOMOLOG
(Thermus
thermophilus) 		5 / 11 THR A  60
THR A  23
THR A  26
GLY A  83
ALA A  81
 GTP  A 700 (-3.6A)
MG  A 701 ( 3.3A)
None
GTP  A 700 (-3.1A)
None
 1.42A 5d0xV-1wdtA:
undetectable
5d0xb-1wdtA:
undetectable		 5d0xV-1wdtA:
15.26
5d0xb-1wdtA:
15.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0X_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 1wdt ELONGATION FACTOR G
HOMOLOG
(Thermus
thermophilus) 		5 / 11 THR A  60
THR A  23
THR A  26
GLY A  83
ALA A  81
 GTP  A 700 (-3.6A)
MG  A 701 ( 3.3A)
None
GTP  A 700 (-3.1A)
None
 1.42A 5d0xH-1wdtA:
undetectable
5d0xN-1wdtA:
undetectable		 5d0xH-1wdtA:
15.26
5d0xN-1wdtA:
15.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4U_A_SAMA301_0
(UNCHARACTERIZED
PROTEIN MJ0489)		 1w5e FTSZ
(Methanocaldococc
us
jannaschii) 		5 / 12 GLY A 104
ILE A  87
THR A 135
GLY A  46
GLY A 176
 None
None
GTP  A 500 (-3.6A)
GTP  A 500 (-2.7A)
None
 1.11A 5d4uA-1w5eA:
5.2		 5d4uA-1w5eA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4U_B_SAMB301_0
(UNCHARACTERIZED
PROTEIN MJ0489)		 1w5e FTSZ
(Methanocaldococc
us
jannaschii) 		5 / 12 GLY A 104
ILE A  87
THR A 135
GLY A  46
GLY A 176
 None
None
GTP  A 500 (-3.6A)
GTP  A 500 (-2.7A)
None
 1.11A 5d4uB-1w5eA:
3.8		 5d4uB-1w5eA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E4D_B_BEZB201_0
(HYDROXYNITRILE LYASE)		 6ewz GTP
PYROPHOSPHOKINASE
(Staphylococcus
aureus) 		5 / 11 VAL A 113
VAL A 114
TYR A 151
ILE A 143
ILE A 121
 None
None
GTP  A 301 (-3.6A)
None
None
 1.06A 5e4dB-6ewzA:
undetectable		 5e4dB-6ewzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E72_A_SAMA400_0
(N2,
N2-DIMETHYLGUANOSINE
TRNA
METHYLTRANSFERASE)		 3ldu PUTATIVE METHYLASE
(Clostridioides
difficile) 		6 / 12 ILE A 206
ILE A 262
ALA A 290
THR A 304
PRO A 307
LEU A 321
 None
GTP  A 383 (-4.2A)
GTP  A 383 (-3.7A)
None
GTP  A 383 (-3.7A)
None
 0.52A 5e72A-3lduA:
13.9		 5e72A-3lduA:
26.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E72_A_SAMA400_1
(N2,
N2-DIMETHYLGUANOSINE
TRNA
METHYLTRANSFERASE)		 3ldu PUTATIVE METHYLASE
(Clostridioides
difficile) 		4 / 4 ASP A 198
GLY A 202
ASP A 261
ASP A 289
 None
GTP  A 383 (-2.6A)
GTP  A 383 (-3.0A)
GTP  A 383 ( 3.8A)
 0.35A 5e72A-3lduA:
13.9		 5e72A-3lduA:
26.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EML_A_SAMA701_1
(PROTEIN ARGININE
N-METHYLTRANSFERASE
5)		 1ckm MRNA CAPPING ENZYME
(Paramecium
bursaria
Chlorella
virus
1) 		4 / 6 TYR A 111
GLY A  85
GLU A 131
ASP A 213
 None
None
GTP  A 899 (-3.0A)
None
 1.23A 5emlA-1ckmA:
undetectable		 5emlA-1ckmA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EQB_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5mn5 CELL DIVISION
PROTEIN FTSZ
(Staphylococcus
aureus) 		5 / 12 GLY A 104
ILE A 217
GLY A 259
GLY A 314
THR A 133
 GTP  A 401 (-3.4A)
None
None
None
None
 1.07A 5eqbA-5mn5A:
undetectable		 5eqbA-5mn5A:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHR_A_SAMA303_1
(CATECHOL
O-METHYLTRANSFERASE)		 2wkp NPH1-1, RAS-RELATED
C3 BOTULINUM TOXIN
SUBSTRATE 1
(Avena
sativa;
Homo
sapiens) 		4 / 5 GLU A 699
TYR A 682
SER A 701
ASP A 664
 None
None
GTP  A1724 (-3.6A)
None
 1.43A 5fhrA-2wkpA:
undetectable		 5fhrA-2wkpA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHR_A_SAMA303_1
(CATECHOL
O-METHYLTRANSFERASE)		 5hzh RAS-RELATED C3
BOTULINUM TOXIN
SUBSTRATE
1,NPH1-1,RAS-RELATED
C3 BOTULINUM TOXIN
SUBSTRATE 1
(Avena
sativa;
Homo
sapiens) 		4 / 5 GLU A 305
TYR A 288
SER A 307
ASP A 270
 None
None
GTP  A 401 (-3.5A)
None
 1.46A 5fhrA-5hzhA:
undetectable		 5fhrA-5hzhA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G5G_C_ACTC1740_0
(PUTATIVE XANTHINE
DEHYDROGENASE YAGS
FAD-BINDING SUBUNIT)		 2x60 MANNOSE-1-PHOSPHATE
GUANYLYLTRANSFERASE
(Thermotoga
maritima) 		4 / 4 VAL A  56
GLU A  80
GLY A  93
LEU A   5
 GTP  A 601 (-4.0A)
GTP  A 601 (-2.9A)
None
None
 1.29A 5g5gC-2x60A:
undetectable		 5g5gC-2x60A:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_A_SAMA301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 3ldu PUTATIVE METHYLASE
(Clostridioides
difficile) 		5 / 12 ASP A 289
ALA A 290
PRO A 307
GLY A 202
THR A 205
 GTP  A 383 ( 3.8A)
GTP  A 383 (-3.7A)
GTP  A 383 (-3.7A)
GTP  A 383 (-2.6A)
GTP  A 383 (-3.5A)
 0.57A 5hfjA-3lduA:
2.4		 5hfjA-3lduA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_B_SAMB301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 3ldu PUTATIVE METHYLASE
(Clostridioides
difficile) 		5 / 12 ALA A 290
PRO A 307
GLY A 202
SER A 203
THR A 205
 GTP  A 383 (-3.7A)
GTP  A 383 (-3.7A)
GTP  A 383 (-2.6A)
GTP  A 383 (-2.7A)
GTP  A 383 (-3.5A)
 0.75A 5hfjB-3lduA:
2.0		 5hfjB-3lduA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_C_SAMC301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 3ldu PUTATIVE METHYLASE
(Clostridioides
difficile) 		5 / 12 ASP A 289
ALA A 290
PRO A 307
GLY A 202
THR A 205
 GTP  A 383 ( 3.8A)
GTP  A 383 (-3.7A)
GTP  A 383 (-3.7A)
GTP  A 383 (-2.6A)
GTP  A 383 (-3.5A)
 0.55A 5hfjC-3lduA:
2.3		 5hfjC-3lduA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_D_SAMD301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 3ldu PUTATIVE METHYLASE
(Clostridioides
difficile) 		6 / 12 ASP A 289
ALA A 290
PRO A 307
GLY A 202
SER A 203
THR A 205
 GTP  A 383 ( 3.8A)
GTP  A 383 (-3.7A)
GTP  A 383 (-3.7A)
GTP  A 383 (-2.6A)
GTP  A 383 (-2.7A)
GTP  A 383 (-3.5A)
 0.69A 5hfjD-3lduA:
2.3		 5hfjD-3lduA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_E_SAME301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 3ldu PUTATIVE METHYLASE
(Clostridioides
difficile) 		5 / 12 ASP A 289
ALA A 290
GLY A 202
SER A 203
THR A 205
 GTP  A 383 ( 3.8A)
GTP  A 383 (-3.7A)
GTP  A 383 (-2.6A)
GTP  A 383 (-2.7A)
GTP  A 383 (-3.5A)
 0.45A 5hfjE-3lduA:
2.0		 5hfjE-3lduA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_F_SAMF301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 3ldu PUTATIVE METHYLASE
(Clostridioides
difficile) 		5 / 12 ASP A 289
ALA A 290
PRO A 307
GLY A 202
SER A 203
 GTP  A 383 ( 3.8A)
GTP  A 383 (-3.7A)
GTP  A 383 (-3.7A)
GTP  A 383 (-2.6A)
GTP  A 383 (-2.7A)
 0.74A 5hfjF-3lduA:
2.1		 5hfjF-3lduA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_H_SAMH301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 3ldu PUTATIVE METHYLASE
(Clostridioides
difficile) 		5 / 12 ASP A 289
ALA A 290
PRO A 307
GLY A 202
THR A 205
 GTP  A 383 ( 3.8A)
GTP  A 383 (-3.7A)
GTP  A 383 (-3.7A)
GTP  A 383 (-2.6A)
GTP  A 383 (-3.5A)
 0.54A 5hfjH-3lduA:
2.1		 5hfjH-3lduA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HG0_A_SAMA301_0
(PANTOTHENATE
SYNTHETASE)		 5mjs TUBULIN ALPHA-1
CHAIN
(Schizosaccharomy
ces
pombe) 		5 / 12 GLY E 147
GLN E  81
GLY E  10
ASP E  73
THR E 149
 GTP  E 500 (-3.1A)
None
GTP  E 500 (-3.1A)
GTP  E 500 (-3.6A)
GTP  E 500 (-3.6A)
 1.14A 5hg0A-5mjsE:
undetectable		 5hg0A-5mjsE:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3C_C_AC2C301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 2v55 RHO-RELATED
GTP-BINDING PROTEIN
RHOE
(Homo
sapiens) 		5 / 11 SER B  79
GLY B  30
VAL B  29
SER B  32
ASP B  31
 GTP  B1201 ( 4.7A)
None
None
GTP  B1201 (-3.3A)
None
 1.01A 5i3cC-2v55B:
2.9		 5i3cC-2v55B:
19.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JH7_B_6K9B503_0
(TUBULIN BETA-2B
CHAIN)		 5nd4 TUBULIN ALPHA CHAIN
(Bos
taurus) 		5 / 11 GLN A  11
GLU A 183
PRO A 222
TYR A 224
LEU A 227
 GTP  A 500 ( 3.1A)
GTP  A 500 (-3.3A)
None
GTP  A 500 (-3.2A)
GTP  A 500 ( 4.1A)
 0.77A 5jh7B-5nd4A:
51.3		 5jh7B-5nd4A:
38.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JH7_D_6K9D502_0
(TUBULIN BETA-2B
CHAIN)		 5nd4 TUBULIN ALPHA CHAIN
(Bos
taurus) 		5 / 11 GLN A  11
ASN A 101
PRO A 222
TYR A 224
LEU A 227
 GTP  A 500 ( 3.1A)
GTP  A 500 (-3.3A)
None
GTP  A 500 (-3.2A)
GTP  A 500 ( 4.1A)
 0.97A 5jh7D-5nd4A:
51.7		 5jh7D-5nd4A:
38.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JH7_D_6K9D502_0
(TUBULIN BETA-2B
CHAIN)		 5nd4 TUBULIN ALPHA CHAIN
(Bos
taurus) 		5 / 11 GLN A  11
GLU A 183
PRO A 222
TYR A 224
LEU A 227
 GTP  A 500 ( 3.1A)
GTP  A 500 (-3.3A)
None
GTP  A 500 (-3.2A)
GTP  A 500 ( 4.1A)
 0.74A 5jh7D-5nd4A:
51.7		 5jh7D-5nd4A:
38.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JKV_A_ASDA602_1
(AROMATASE)		 2v4y URIDYLATE KINASE
(Escherichia
coli) 		5 / 12 ALA A 148
THR A 145
LEU A  21
MET A  91
LEU A  16
 None
GTP  A1243 (-4.5A)
None
None
None
 1.24A 5jkvA-2v4yA:
undetectable		 5jkvA-2v4yA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L66_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 1wdt ELONGATION FACTOR G
HOMOLOG
(Thermus
thermophilus) 		5 / 11 THR A  60
THR A  23
THR A  26
GLY A  83
ALA A  81
 GTP  A 700 (-3.6A)
MG  A 701 ( 3.3A)
None
GTP  A 700 (-3.1A)
None
 1.44A 5l66H-1wdtA:
undetectable
5l66N-1wdtA:
undetectable		 5l66H-1wdtA:
15.26
5l66N-1wdtA:
15.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L6E_A_SAMA601_0
(N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT)		 5a96 POLYHEDRIN
(Cypovirus
14) 		5 / 12 ILE A 119
PRO A  99
LEU A  61
PHE A 163
GLY A 164
 None
None
None
None
GTP  A1250 (-3.3A)
 1.15A 5l6eA-5a96A:
undetectable		 5l6eA-5a96A:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M54_E_TA1E502_1
(TUBULIN BETA-2B
CHAIN)		 1wdt ELONGATION FACTOR G
HOMOLOG
(Thermus
thermophilus) 		5 / 12 ASP A  50
ALA A  81
THR A 115
GLN A 112
GLY A  21
 MG  A 701 ( 4.2A)
None
None
None
GTP  A 700 (-3.3A)
 1.18A 5m54E-1wdtA:
2.7		 5m54E-1wdtA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUI_B_CTCB405_0
(TETRACYCLINE
DESTRUCTASE TET(50))		 5ucy TUBULIN ALPHA CHAIN
(Tetrahymena
thermophila) 		5 / 12 GLY A 148
PHE A 103
LEU A 194
GLY A 168
GLY A 142
 None
None
None
None
GTP  A 501 (-2.8A)
 1.31A 5tuiB-5ucyA:
undetectable		 5tuiB-5ucyA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V0V_A_8QPA613_1
(SERUM ALBUMIN)		 1w5e FTSZ
(Methanocaldococc
us
jannaschii) 		4 / 8 ARG A 169
ALA A 173
SER A 139
GLY A 130
 GTP  A 500 (-3.5A)
None
None
GTP  A 500 (-3.5A)
 0.98A 5v0vA-1w5eA:
undetectable		 5v0vA-1w5eA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUN_A_MTLA805_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5w3f TUBULIN ALPHA-1
CHAIN
(Saccharomyces
cerevisiae) 		4 / 8 SER A 224
GLN A  15
PHE A 225
ASN A 227
 None
None
GTP  A 502 (-3.8A)
None
 1.18A 5vunA-5w3fA:
undetectable		 5vunA-5w3fA:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUN_B_MTLB805_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5w3f TUBULIN ALPHA-1
CHAIN
(Saccharomyces
cerevisiae) 		4 / 8 SER A 224
GLN A  15
PHE A 225
ASN A 227
 None
None
GTP  A 502 (-3.8A)
None
 1.18A 5vunB-5w3fA:
undetectable		 5vunB-5w3fA:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUO_B_MTLB805_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5w3f TUBULIN ALPHA-1
CHAIN
(Saccharomyces
cerevisiae) 		4 / 8 SER A 224
GLN A  15
PHE A 225
ASN A 227
 None
None
GTP  A 502 (-3.8A)
None
 1.15A 5vuoB-5w3fA:
undetectable		 5vuoB-5w3fA:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W97_J_CHDJ101_1
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5a96 POLYHEDRIN
(Cypovirus
14) 		4 / 5 ARG A 168
MET A 173
THR A 172
LEU A  61
 GTP  A1250 (-4.3A)
None
None
None
 1.09A 5w97J-5a96A:
undetectable		 5w97J-5a96A:
12.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WAU_J_CHDJ101_1
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5a96 POLYHEDRIN
(Cypovirus
14) 		4 / 5 ARG A 168
MET A 173
THR A 172
LEU A  61
 GTP  A1250 (-4.3A)
None
None
None
 1.30A 5wauJ-5a96A:
undetectable		 5wauJ-5a96A:
12.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1F_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5a96 POLYHEDRIN
(Cypovirus
14) 		4 / 5 ARG A 168
MET A 173
THR A 172
LEU A  61
 GTP  A1250 (-4.3A)
None
None
None
 1.16A 5x1fW-5a96A:
undetectable		 5x1fW-5a96A:
12.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7F_A_SAMA301_0
(PUTATIVE
O-METHYLTRANSFERASE
RV1220C)		 5mn5 CELL DIVISION
PROTEIN FTSZ
(Staphylococcus
aureus) 		5 / 12 GLY A  18
VAL A 101
GLY A 104
GLY A  20
ASP A 187
 None
None
GTP  A 401 (-3.4A)
GTP  A 401 (-3.4A)
GTP  A 401 (-2.9A)
 1.15A 5x7fA-5mn5A:
4.5		 5x7fA-5mn5A:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7F_A_SAMA301_0
(PUTATIVE
O-METHYLTRANSFERASE
RV1220C)		 5w3f TUBULIN ALPHA-1
CHAIN
(Saccharomyces
cerevisiae) 		5 / 12 GLY A 144
GLY A 107
GLY A 149
ALA A 100
ASP A  99
 GTP  A 502 (-2.8A)
None
None
GTP  A 502 ( 4.8A)
None
 0.97A 5x7fA-5w3fA:
3.6		 5x7fA-5w3fA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z86_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5a96 POLYHEDRIN
(Cypovirus
14) 		4 / 5 ARG A 168
MET A 173
THR A 172
LEU A  61
 GTP  A1250 (-4.3A)
None
None
None
 1.26A 5z86J-5a96A:
undetectable		 5z86J-5a96A:
12.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZWR_A_9KLA402_0
(EST-Y29)		 3ffu PROBABLE
PYROPHOSPHOHYDROLASE
(Bdellovibrio
bacteriovorus) 		5 / 12 PHE A  28
ILE A 143
LEU A  86
GLY A  54
ALA A  26
 None
None
None
GTP  A4033 ( 4.0A)
GTP  A4033 ( 4.1A)
 1.22A 5zwrA-3ffuA:
undetectable		 5zwrA-3ffuA:
14.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AUU_B_MTLB805_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5w3f TUBULIN ALPHA-1
CHAIN
(Saccharomyces
cerevisiae) 		4 / 8 SER A 224
GLN A  15
PHE A 225
ASN A 227
 None
None
GTP  A 502 (-3.8A)
None
 1.14A 6auuB-5w3fA:
undetectable		 6auuB-5w3fA:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BQ4_A_ADNA401_1
(THERMOSPERMINE
SYNTHASE ACAULIS
PROTEIN)		 3ldu PUTATIVE METHYLASE
(Clostridioides
difficile) 		5 / 12 ASP A 261
ILE A 262
ASP A 263
ASP A 289
ALA A 290
 GTP  A 383 (-3.0A)
GTP  A 383 (-4.2A)
None
GTP  A 383 ( 3.8A)
GTP  A 383 (-3.7A)
 0.86A 6bq4A-3lduA:
8.4		 6bq4A-3lduA:
12.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BQ4_B_ADNB401_1
(THERMOSPERMINE
SYNTHASE ACAULIS
PROTEIN)		 3ldu PUTATIVE METHYLASE
(Clostridioides
difficile) 		5 / 12 ASP A 261
ILE A 262
ASP A 263
ASP A 289
ALA A 290
 GTP  A 383 (-3.0A)
GTP  A 383 (-4.2A)
None
GTP  A 383 ( 3.8A)
GTP  A 383 (-3.7A)
 0.88A 6bq4B-3lduA:
8.3		 6bq4B-3lduA:
12.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_A_SUEA1202_0
(NS3 PROTEASE)		 5w3f TUBULIN ALPHA-1
CHAIN
(Saccharomyces
cerevisiae) 		5 / 12 GLY A 145
VAL A 189
ILE A  16
GLY A  10
ALA A 171
 GTP  A 502 (-4.6A)
None
None
GTP  A 502 (-3.6A)
None
 1.12A 6c2mA-5w3fA:
undetectable		 6c2mA-5w3fA:
11.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_B_SUEB1202_0
(NS3 PROTEASE)		 5w3f TUBULIN ALPHA-1
CHAIN
(Saccharomyces
cerevisiae) 		5 / 12 GLY A 145
VAL A 189
ILE A  16
GLY A  10
ALA A 171
 GTP  A 502 (-4.6A)
None
None
GTP  A 502 (-3.6A)
None
 1.18A 6c2mB-5w3fA:
undetectable		 6c2mB-5w3fA:
11.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EKZ_A_SNPA413_0
(AROMATIC
PEROXYGENASE)		 5mjs TUBULIN ALPHA-1
CHAIN
(Schizosaccharomy
ces
pombe) 		4 / 7 GLN E  11
GLY E 152
SER E 104
GLY E 148
 GTP  E 500 (-2.8A)
None
GTP  E 500 (-2.2A)
GTP  E 500 (-3.2A)
 0.92A 6ekzA-5mjsE:
undetectable		 6ekzA-5mjsE:
15.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F8C_A_STRA502_1
(CYTOCHROME P450
CYP260A1)		 3ldu PUTATIVE METHYLASE
(Clostridioides
difficile) 		4 / 6 ALA A 182
GLY A 204
ILE A 257
PHE A 255
 None
GTP  A 383 ( 4.3A)
None
None
 0.91A 6f8cA-3lduA:
1.1		 6f8cA-3lduA:
12.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NKN_W_CHDW102_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5a96 POLYHEDRIN
(Cypovirus
14) 		4 / 5 ARG A 168
MET A 173
THR A 172
LEU A  61
 GTP  A1250 (-4.3A)
None
None
None
 1.21A 6nknW-5a96A:
undetectable		 6nknW-5a96A:
12.55