SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'GSU'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QE6_A_SAMA400_1
(UNCHARACTERIZED
PROTEIN TFU_2867)		 3al0 GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT
C,LINKER,GLUTAMATE--
TRNA LIGASE 2
(Thermotoga
maritima;
synthetic
construct) 		3 / 3 ASN C 152
ARG C 132
ASP C 323
 None
GSU  C1001 (-2.2A)
GSU  C1001 (-3.0A)
 0.95A 2qe6A-3al0C:
undetectable		 2qe6A-3al0C:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QE6_B_SAMB400_1
(UNCHARACTERIZED
PROTEIN TFU_2867)		 3al0 GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT
C,LINKER,GLUTAMATE--
TRNA LIGASE 2
(Thermotoga
maritima;
synthetic
construct) 		3 / 3 ASN C 152
ARG C 132
ASP C 323
 None
GSU  C1001 (-2.2A)
GSU  C1001 (-3.0A)
 0.93A 2qe6B-3al0C:
undetectable		 2qe6B-3al0C:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LCV_B_SAMB301_1
(SISOMICIN-GENTAMICIN
RESISTANCE METHYLASE
SGM)		 3akz GLUTAMYL-TRNA
SYNTHETASE 2
(Thermotoga
maritima) 		3 / 3 ARG B  70
ASP B 219
GLN B 227
 C  F  75 ( 3.5A)
GSU  B1001 (-4.0A)
None
 0.91A 3lcvB-3akzB:
undetectable		 3lcvB-3akzB:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_A_ZPCA1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 3al0 GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT
C,LINKER,GLUTAMATE--
TRNA LIGASE 2
(Thermotoga
maritima;
synthetic
construct) 		4 / 7 PHE C 371
VAL C 143
ILE C 351
GLU C 374
 None
None
GSU  C1001 (-4.4A)
None
 1.09A 4a97E-3al0C:
undetectable		 4a97E-3al0C:
16.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_B_STRB601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 3akz GLUTAMYL-TRNA
SYNTHETASE 2
(Thermotoga
maritima) 		4 / 5 ILE B  63
LEU B  61
GLU B  64
VAL B 214
 None
None
GSU  B1001 (-3.8A)
None
 1.00A 4nkxB-3akzB:
undetectable		 4nkxB-3akzB:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZC_A_ACTA406_0
(PROTON-GATED ION
CHANNEL)		 3akz GLUTAMYL-TRNA
SYNTHETASE 2
(Thermotoga
maritima) 		4 / 4 LEU B 228
ILE B 230
ARG B 216
TYR B 231
 None
None
GSU  B1001 (-4.0A)
None
 1.12A 4zzcA-3akzB:
undetectable		 4zzcA-3akzB:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_3_BEZ3801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
BEZ-LEU-LEU)		 3al0 GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT
C,LINKER,GLUTAMATE--
TRNA LIGASE 2
(Thermotoga
maritima;
synthetic
construct) 		4 / 4 LEU C 350
ILE C 348
GLY C 416
ILE C 412
 GSU  C1001 (-3.8A)
None
None
None
 0.83A 5dzk3-3al0C:
undetectable
5dzkm-3al0C:
undetectable		 5dzk3-3al0C:
4.65
5dzkm-3al0C:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_W_BEZW801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 3al0 GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT
C,LINKER,GLUTAMATE--
TRNA LIGASE 2
(Thermotoga
maritima;
synthetic
construct) 		4 / 5 ILE C 348
GLY C 416
ILE C 412
LEU C 350
 None
None
None
GSU  C1001 (-3.8A)
 0.80A 5dzkB-3al0C:
undetectable
5dzkI-3al0C:
undetectable
5dzkW-3al0C:
undetectable		 5dzkB-3al0C:
18.89
5dzkI-3al0C:
15.62
5dzkW-3al0C:
4.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_X_BEZX801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
BEZ-LEU-LEU)		 3al0 GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT
C,LINKER,GLUTAMATE--
TRNA LIGASE 2
(Thermotoga
maritima;
synthetic
construct) 		4 / 5 ILE C 348
GLY C 416
ILE C 412
LEU C 350
 None
None
None
GSU  C1001 (-3.8A)
 0.80A 5dzki-3al0C:
undetectable
5dzkj-3al0C:
undetectable
5dzkx-3al0C:
undetectable		 5dzki-3al0C:
15.62
5dzkj-3al0C:
15.62
5dzkx-3al0C:
4.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HG0_A_SAMA301_0
(PANTOTHENATE
SYNTHETASE)		 3akz GLUTAMYL-TRNA
SYNTHETASE 2
(Thermotoga
maritima) 		5 / 12 HIS B  38
GLY B  40
GLY B 217
ASP B 219
LEU B 255
 GSU  B1001 ( 4.8A)
GSU  B1001 (-3.7A)
GSU  B1001 (-3.0A)
GSU  B1001 (-4.0A)
GSU  B1001 (-4.5A)
 0.83A 5hg0A-3akzB:
7.3		 5hg0A-3akzB:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HG0_A_SAMA301_0
(PANTOTHENATE
SYNTHETASE)		 3al0 GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT
C,LINKER,GLUTAMATE--
TRNA LIGASE 2
(Thermotoga
maritima;
synthetic
construct) 		5 / 12 HIS C 142
GLY C 144
GLY C 321
ASP C 323
LEU C 359
 GSU  C1001 ( 4.8A)
GSU  C1001 (-3.5A)
GSU  C1001 (-2.7A)
GSU  C1001 (-3.0A)
GSU  C1001 (-4.6A)
 1.07A 5hg0A-3al0C:
8.8		 5hg0A-3al0C:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HG0_A_SAMA301_0
(PANTOTHENATE
SYNTHETASE)		 3al0 GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT
C,LINKER,GLUTAMATE--
TRNA LIGASE 2
(Thermotoga
maritima;
synthetic
construct) 		5 / 12 HIS C 142
GLY C 144
VAL C 306
ASP C 323
LEU C 359
 GSU  C1001 ( 4.8A)
GSU  C1001 (-3.5A)
None
GSU  C1001 (-3.0A)
GSU  C1001 (-4.6A)
 1.04A 5hg0A-3al0C:
8.8		 5hg0A-3al0C:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HG0_B_SAMB301_0
(PANTOTHENATE
SYNTHETASE)		 3akz GLUTAMYL-TRNA
SYNTHETASE 2
(Thermotoga
maritima) 		5 / 12 HIS B  38
GLY B  40
GLY B 217
ASP B 219
LEU B 255
 GSU  B1001 ( 4.8A)
GSU  B1001 (-3.7A)
GSU  B1001 (-3.0A)
GSU  B1001 (-4.0A)
GSU  B1001 (-4.5A)
 0.82A 5hg0B-3akzB:
7.4		 5hg0B-3akzB:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HG0_B_SAMB301_0
(PANTOTHENATE
SYNTHETASE)		 3al0 GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT
C,LINKER,GLUTAMATE--
TRNA LIGASE 2
(Thermotoga
maritima;
synthetic
construct) 		5 / 12 HIS C 142
GLY C 144
VAL C 306
ASP C 323
LEU C 359
 GSU  C1001 ( 4.8A)
GSU  C1001 (-3.5A)
None
GSU  C1001 (-3.0A)
GSU  C1001 (-4.6A)
 1.03A 5hg0B-3al0C:
8.9		 5hg0B-3al0C:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TT3_H_EZLH303_1
(ALPHA-CARBONIC
ANHYDRASE)		 3al0 GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT
C,LINKER,GLUTAMATE--
TRNA LIGASE 2
(Thermotoga
maritima;
synthetic
construct) 		4 / 8 HIS C 142
VAL C 368
THR C 148
ALA C 149
 GSU  C1001 ( 4.8A)
None
GSU  C1001 (-3.0A)
None
 0.91A 5tt3H-3al0C:
undetectable		 5tt3H-3al0C:
18.73