SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'GST'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RQJ_A_RISA901_1
(GERANYLTRANSTRANSFER
ASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		7 / 11 SER A  76
LEU A  77
ASP A  80
ASP A  86
ARG A  91
GLN A 153
LYS A 230
 GST  A 302 (-3.9A)
None
CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
GST  A 302 (-3.7A)
GST  A 302 (-2.7A)
 0.65A 1rqjA-4llsA:
42.4		 1rqjA-4llsA:
42.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RQJ_A_RISA901_1
(GERANYLTRANSTRANSFER
ASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		9 / 11 SER A  76
LEU A  77
ASP A  80
ASP A  86
ARG A  91
LYS A 178
THR A 179
ASP A 216
LYS A 230
 GST  A 302 (-3.9A)
None
CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
GST  A 302 (-3.4A)
IPE  A 301 (-4.2A)
CA  A 303 (-2.9A)
GST  A 302 (-2.7A)
 0.57A 1rqjA-4llsA:
42.4		 1rqjA-4llsA:
42.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RQJ_A_RISA901_1
(GERANYLTRANSTRANSFER
ASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		9 / 11 SER A  76
LEU A  77
ASP A  80
ASP A  86
ARG A  91
THR A 179
GLN A 213
ASP A 216
LYS A 230
 GST  A 302 (-3.9A)
None
CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
IPE  A 301 (-4.2A)
IPE  A 301 ( 4.1A)
CA  A 303 (-2.9A)
GST  A 302 (-2.7A)
 0.66A 1rqjA-4llsA:
42.4		 1rqjA-4llsA:
42.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RQJ_B_RISB903_1
(GERANYLTRANSTRANSFER
ASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		7 / 11 SER A  76
LEU A  77
ASP A  80
ASP A  86
ARG A  91
GLN A 153
LYS A 230
 GST  A 302 (-3.9A)
None
CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
GST  A 302 (-3.7A)
GST  A 302 (-2.7A)
 0.70A 1rqjB-4llsA:
42.2		 1rqjB-4llsA:
42.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RQJ_B_RISB903_1
(GERANYLTRANSTRANSFER
ASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		10 / 11 SER A  76
LEU A  77
ASP A  80
ASP A  86
ARG A  91
LYS A 178
THR A 179
GLN A 213
ASP A 216
LYS A 230
 GST  A 302 (-3.9A)
None
CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
GST  A 302 (-3.4A)
IPE  A 301 (-4.2A)
IPE  A 301 ( 4.1A)
CA  A 303 (-2.9A)
GST  A 302 (-2.7A)
 0.70A 1rqjB-4llsA:
42.2		 1rqjB-4llsA:
42.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDT_A_VIAA1000_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 3v1v 2-METHYLISOBORNEOL
SYNTHASE
(Streptomyces
coelicolor) 		5 / 12 ALA A 221
ILE A 222
VAL A 196
ALA A 195
MET A 190
 None
None
None
None
GST  A 511 (-3.0A)
 1.31A 1udtA-3v1vA:
undetectable		 1udtA-3v1vA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V54_B_CHDB4085_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I
CYTOCHROME C OXIDASE
POLYPEPTIDE II
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIA-HEART)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		5 / 11 MET A 149
GLY A 148
GLN A 175
ARG A  44
GLY A 184
 GST  A 302 ( 4.1A)
None
None
IPE  A 301 (-3.1A)
None
 1.30A 1v54A-4llsA:
0.6
1v54B-4llsA:
undetectable
1v54T-4llsA:
undetectable		 1v54A-4llsA:
20.31
1v54B-4llsA:
22.93
1v54T-4llsA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YHL_A_RISA1400_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		7 / 11 LEU A  77
ASP A  80
ASP A  86
ARG A  91
GLN A 153
ASP A 216
LYS A 230
 None
CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
GST  A 302 (-3.7A)
CA  A 303 (-2.9A)
GST  A 302 (-2.7A)
 0.75A 1yhlA-4llsA:
28.9		 1yhlA-4llsA:
26.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YHL_A_RISA1400_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		8 / 11 LEU A  77
ASP A  80
ASP A  86
ARG A  91
LYS A 178
THR A 179
ASP A 216
LYS A 230
 None
CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
GST  A 302 (-3.4A)
IPE  A 301 (-4.2A)
CA  A 303 (-2.9A)
GST  A 302 (-2.7A)
 0.62A 1yhlA-4llsA:
28.9		 1yhlA-4llsA:
26.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YHL_A_RISA1400_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		8 / 11 LEU A  77
ASP A  80
ASP A  86
ARG A  91
THR A 179
GLN A 213
ASP A 216
LYS A 230
 None
CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
IPE  A 301 (-4.2A)
IPE  A 301 ( 4.1A)
CA  A 303 (-2.9A)
GST  A 302 (-2.7A)
 0.58A 1yhlA-4llsA:
28.9		 1yhlA-4llsA:
26.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YQ7_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHETASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		8 / 11 LEU A  77
ASP A  80
ASP A  86
ARG A  91
GLN A 153
LYS A 178
ASP A 216
LYS A 230
 None
CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
GST  A 302 (-3.7A)
GST  A 302 (-3.4A)
CA  A 303 (-2.9A)
GST  A 302 (-2.7A)
 0.86A 1yq7A-4llsA:
28.6		 1yq7A-4llsA:
28.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YQ7_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHETASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		8 / 11 LEU A  77
ASP A  80
ASP A  86
ARG A  91
LYS A 178
THR A 179
ASP A 216
LYS A 230
 None
CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
GST  A 302 (-3.4A)
IPE  A 301 (-4.2A)
CA  A 303 (-2.9A)
GST  A 302 (-2.7A)
 0.69A 1yq7A-4llsA:
28.6		 1yq7A-4llsA:
28.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YQ7_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHETASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		8 / 11 LEU A  77
ASP A  80
ASP A  86
ARG A  91
THR A 179
GLN A 213
ASP A 216
LYS A 230
 None
CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
IPE  A 301 (-4.2A)
IPE  A 301 ( 4.1A)
CA  A 303 (-2.9A)
GST  A 302 (-2.7A)
 0.69A 1yq7A-4llsA:
28.6		 1yq7A-4llsA:
28.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YV5_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHETASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		7 / 10 LEU A  77
ASP A  80
ASP A  86
ARG A  91
GLN A 153
ASP A 216
LYS A 230
 None
CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
GST  A 302 (-3.7A)
CA  A 303 (-2.9A)
GST  A 302 (-2.7A)
 0.69A 1yv5A-4llsA:
28.7		 1yv5A-4llsA:
28.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YV5_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHETASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		9 / 10 LEU A  77
ASP A  80
ASP A  86
ARG A  91
LYS A 178
THR A 179
GLN A 213
ASP A 216
LYS A 230
 None
CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
GST  A 302 (-3.4A)
IPE  A 301 (-4.2A)
IPE  A 301 ( 4.1A)
CA  A 303 (-2.9A)
GST  A 302 (-2.7A)
 0.67A 1yv5A-4llsA:
28.7		 1yv5A-4llsA:
28.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZW5_A_ZOLA901_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		6 / 9 ASP A  80
ASP A  86
ARG A  91
GLN A 153
ASP A 216
LYS A 230
 CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
GST  A 302 (-3.7A)
CA  A 303 (-2.9A)
GST  A 302 (-2.7A)
 0.77A 1zw5A-4llsA:
29.5		 1zw5A-4llsA:
25.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZW5_A_ZOLA901_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		8 / 9 ASP A  80
ASP A  86
ARG A  91
LYS A 178
THR A 179
GLN A 213
ASP A 216
LYS A 230
 CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
GST  A 302 (-3.4A)
IPE  A 301 (-4.2A)
IPE  A 301 ( 4.1A)
CA  A 303 (-2.9A)
GST  A 302 (-2.7A)
 0.74A 1zw5A-4llsA:
29.5		 1zw5A-4llsA:
25.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E91_A_ZOLA901_1
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		5 / 9 ASP A  80
ASP A  86
ARG A  91
GLN A 153
ASP A 216
 CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
GST  A 302 (-3.7A)
CA  A 303 (-2.9A)
 0.67A 2e91A-4llsA:
21.3		 2e91A-4llsA:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E91_A_ZOLA901_1
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		6 / 9 ASP A  80
ASP A  86
ARG A  91
LYS A 178
THR A 179
ASP A 216
 CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
GST  A 302 (-3.4A)
IPE  A 301 (-4.2A)
CA  A 303 (-2.9A)
 0.69A 2e91A-4llsA:
21.3		 2e91A-4llsA:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E91_A_ZOLA901_1
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		6 / 9 ASP A  80
ASP A  86
ARG A  91
THR A 179
GLN A 213
ASP A 216
 CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
IPE  A 301 (-4.2A)
IPE  A 301 ( 4.1A)
CA  A 303 (-2.9A)
 0.68A 2e91A-4llsA:
21.3		 2e91A-4llsA:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E91_B_ZOLB902_1
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		7 / 9 ASP A  80
ASP A  86
ARG A  91
GLN A 153
LYS A 178
THR A 179
ASP A 216
 CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
GST  A 302 (-3.7A)
GST  A 302 (-3.4A)
IPE  A 301 (-4.2A)
CA  A 303 (-2.9A)
 0.86A 2e91B-4llsA:
20.5		 2e91B-4llsA:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E91_B_ZOLB902_1
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		6 / 9 ASP A  80
ASP A  86
ARG A  91
THR A 179
GLN A 213
ASP A 216
 CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
IPE  A 301 (-4.2A)
IPE  A 301 ( 4.1A)
CA  A 303 (-2.9A)
 0.75A 2e91B-4llsA:
20.5		 2e91B-4llsA:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIM_N_CHDN1604_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		5 / 11 ARG A  44
GLY A 184
MET A 149
GLY A 148
GLN A 175
 IPE  A 301 (-3.1A)
None
GST  A 302 ( 4.1A)
None
None
 1.36A 2eimG-4llsA:
undetectable
2eimN-4llsA:
0.9
2eimO-4llsA:
undetectable		 2eimG-4llsA:
14.29
2eimN-4llsA:
20.31
2eimO-4llsA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F89_F_210F9001_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		8 / 9 ASP A  80
ASP A  86
ARG A  91
LYS A 178
THR A 179
GLN A 213
ASP A 216
LYS A 230
 CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
GST  A 302 (-3.4A)
IPE  A 301 (-4.2A)
IPE  A 301 ( 4.1A)
CA  A 303 (-2.9A)
GST  A 302 (-2.7A)
 0.65A 2f89F-4llsA:
30.3		 2f89F-4llsA:
25.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8C_F_ZOLF9001_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		7 / 11 LEU A  77
ASP A  80
ASP A  86
ARG A  91
GLN A 153
ASP A 216
LYS A 230
 None
CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
GST  A 302 (-3.7A)
CA  A 303 (-2.9A)
GST  A 302 (-2.7A)
 0.70A 2f8cF-4llsA:
29.6		 2f8cF-4llsA:
25.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8C_F_ZOLF9001_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		9 / 11 LEU A  77
ASP A  80
ASP A  86
ARG A  91
LYS A 178
THR A 179
GLN A 213
ASP A 216
LYS A 230
 None
CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
GST  A 302 (-3.4A)
IPE  A 301 (-4.2A)
IPE  A 301 ( 4.1A)
CA  A 303 (-2.9A)
GST  A 302 (-2.7A)
 0.69A 2f8cF-4llsA:
29.6		 2f8cF-4llsA:
25.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8Z_F_ZOLF5001_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		8 / 10 LEU A  77
ASP A  80
ASP A  86
ARG A  91
GLN A 153
LYS A 178
ASP A 216
LYS A 230
 None
CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
GST  A 302 (-3.7A)
GST  A 302 (-3.4A)
CA  A 303 (-2.9A)
GST  A 302 (-2.7A)
 0.77A 2f8zF-4llsA:
30.3		 2f8zF-4llsA:
25.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8Z_F_ZOLF5001_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		9 / 10 LEU A  77
ASP A  80
ASP A  86
ARG A  91
LYS A 178
THR A 179
GLN A 213
ASP A 216
LYS A 230
 None
CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
GST  A 302 (-3.4A)
IPE  A 301 (-4.2A)
IPE  A 301 ( 4.1A)
CA  A 303 (-2.9A)
GST  A 302 (-2.7A)
 0.69A 2f8zF-4llsA:
30.3		 2f8zF-4llsA:
25.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F94_F_BFQF9001_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		10 / 12 LEU A  77
ASP A  80
ASP A  86
ARG A  91
GLN A 153
LYS A 178
THR A 179
GLN A 213
ASP A 216
LYS A 230
 None
CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
GST  A 302 (-3.7A)
GST  A 302 (-3.4A)
IPE  A 301 (-4.2A)
IPE  A 301 ( 4.1A)
CA  A 303 (-2.9A)
GST  A 302 (-2.7A)
 0.63A 2f94F-4llsA:
29.3		 2f94F-4llsA:
25.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F9K_F_ZOLF9001_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		7 / 10 LEU A  77
ASP A  80
ASP A  86
ARG A  91
GLN A 153
ASP A 216
LYS A 230
 None
CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
GST  A 302 (-3.7A)
CA  A 303 (-2.9A)
GST  A 302 (-2.7A)
 0.72A 2f9kF-4llsA:
29.2		 2f9kF-4llsA:
25.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F9K_F_ZOLF9001_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		9 / 10 LEU A  77
ASP A  80
ASP A  86
ARG A  91
LYS A 178
THR A 179
GLN A 213
ASP A 216
LYS A 230
 None
CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
GST  A 302 (-3.4A)
IPE  A 301 (-4.2A)
IPE  A 301 ( 4.1A)
CA  A 303 (-2.9A)
GST  A 302 (-2.7A)
 0.70A 2f9kF-4llsA:
29.2		 2f9kF-4llsA:
25.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O1O_A_RISA400_1
(PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		5 / 9 LEU A  77
ASP A  80
ASP A  86
ARG A  91
GLN A 153
 None
CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
GST  A 302 (-3.7A)
 0.63A 2o1oA-4llsA:
24.8		 2o1oA-4llsA:
25.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O1O_A_RISA400_1
(PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		6 / 9 LEU A  77
ASP A  80
ASP A  86
ARG A  91
LYS A 178
THR A 179
 None
CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
GST  A 302 (-3.4A)
IPE  A 301 (-4.2A)
 0.53A 2o1oA-4llsA:
24.8		 2o1oA-4llsA:
25.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O1O_A_RISA400_1
(PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		5 / 9 LEU A  77
ASP A  86
ARG A  91
THR A 179
GLN A 213
 None
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
IPE  A 301 (-4.2A)
IPE  A 301 ( 4.1A)
 0.73A 2o1oA-4llsA:
24.8		 2o1oA-4llsA:
25.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O1O_B_RISB400_1
(PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		5 / 10 LEU A  77
ASP A  80
ASP A  86
ARG A  91
GLN A 153
 None
CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
GST  A 302 (-3.7A)
 0.59A 2o1oB-4llsA:
25.6		 2o1oB-4llsA:
25.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O1O_B_RISB400_1
(PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		6 / 10 LEU A  77
ASP A  80
ASP A  86
ARG A  91
LYS A 178
THR A 179
 None
CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
GST  A 302 (-3.4A)
IPE  A 301 (-4.2A)
 0.65A 2o1oB-4llsA:
25.6		 2o1oB-4llsA:
25.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O1O_B_RISB400_1
(PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		6 / 10 LEU A  77
ASP A  86
ARG A  91
LYS A 178
THR A 179
GLN A 213
 None
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
GST  A 302 (-3.4A)
IPE  A 301 (-4.2A)
IPE  A 301 ( 4.1A)
 0.82A 2o1oB-4llsA:
25.6		 2o1oB-4llsA:
25.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q58_A_ZOLA1_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		5 / 10 LEU A  77
ASP A  80
ARG A  91
GLN A 153
ASP A 235
 None
CA  A 304 ( 2.9A)
GST  A 302 (-2.9A)
GST  A 302 (-3.7A)
CA  A 303 ( 4.3A)
 1.08A 2q58A-4llsA:
25.2		 2q58A-4llsA:
25.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q58_A_ZOLA1_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		5 / 10 LEU A  77
ASP A  80
ASP A  86
ARG A  91
ASP A 220
 None
CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
None
 1.38A 2q58A-4llsA:
25.2		 2q58A-4llsA:
25.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q58_A_ZOLA1_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		5 / 10 LEU A  77
ASP A  80
ASP A  86
ARG A  91
GLN A 153
 None
CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
GST  A 302 (-3.7A)
 0.94A 2q58A-4llsA:
25.2		 2q58A-4llsA:
25.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q58_A_ZOLA1_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		7 / 10 LEU A  77
ASP A  80
ASP A  86
ARG A  91
LYS A 178
THR A 179
GLN A 213
 None
CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
GST  A 302 (-3.4A)
IPE  A 301 (-4.2A)
IPE  A 301 ( 4.1A)
 0.95A 2q58A-4llsA:
25.2		 2q58A-4llsA:
25.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q58_A_ZOLA1_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		6 / 10 LEU A  77
ASP A  86
ARG A  91
THR A 179
GLN A 213
ASP A 217
 None
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
IPE  A 301 (-4.2A)
IPE  A 301 ( 4.1A)
None
 0.89A 2q58A-4llsA:
25.2		 2q58A-4llsA:
25.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q58_B_ZOLB2_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		5 / 9 ASP A  80
ASP A  86
ARG A  91
LYS A 178
THR A 179
 CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
GST  A 302 (-3.4A)
IPE  A 301 (-4.2A)
 0.66A 2q58B-4llsA:
25.2		 2q58B-4llsA:
25.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q58_B_ZOLB2_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		5 / 9 ASP A  86
ARG A  91
LYS A 178
THR A 179
GLN A 213
 CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
GST  A 302 (-3.4A)
IPE  A 301 (-4.2A)
IPE  A 301 ( 4.1A)
 0.86A 2q58B-4llsA:
25.2		 2q58B-4llsA:
25.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QIS_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHETASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		7 / 10 LEU A  77
ASP A  80
ASP A  86
ARG A  91
GLN A 153
ASP A 216
LYS A 230
 None
CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
GST  A 302 (-3.7A)
CA  A 303 (-2.9A)
GST  A 302 (-2.7A)
 0.73A 2qisA-4llsA:
29.0		 2qisA-4llsA:
29.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QIS_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHETASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		8 / 10 LEU A  77
ASP A  80
ASP A  86
ARG A  91
LYS A 178
GLN A 213
ASP A 216
LYS A 230
 None
CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
GST  A 302 (-3.4A)
IPE  A 301 ( 4.1A)
CA  A 303 (-2.9A)
GST  A 302 (-2.7A)
 0.67A 2qisA-4llsA:
29.0		 2qisA-4llsA:
29.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		 4od5 4-HYDROXYBENZOATE
OCTAPRENYLTRANSFERAS
E
(Aeropyrum
pernix) 		5 / 12 VAL A 137
PHE A  15
SER A  12
VAL A 171
GLY A 130
 None
None
GST  A 301 ( 4.1A)
None
None
 1.19A 2x2iA-4od5A:
undetectable		 2x2iA-4od5A:
13.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_D_QPSD1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		 4od5 4-HYDROXYBENZOATE
OCTAPRENYLTRANSFERAS
E
(Aeropyrum
pernix) 		5 / 10 VAL A 137
PHE A  15
SER A  12
VAL A 171
GLY A 130
 None
None
GST  A 301 ( 4.1A)
None
None
 1.22A 2x2iD-4od5A:
undetectable		 2x2iD-4od5A:
13.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZXW_G_CHDG86_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 6A2
CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		5 / 11 ARG A  44
GLY A 184
MET A 149
GLY A 148
GLN A 175
 IPE  A 301 (-3.1A)
None
GST  A 302 ( 4.1A)
None
None
 1.32A 2zxwG-4llsA:
undetectable
2zxwN-4llsA:
1.3
2zxwO-4llsA:
undetectable		 2zxwG-4llsA:
14.29
2zxwN-4llsA:
20.31
2zxwO-4llsA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABK_B_CHDB1085_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		5 / 11 MET A 149
GLN A 175
THR A 172
ARG A  44
GLY A 184
 GST  A 302 ( 4.1A)
None
None
IPE  A 301 (-3.1A)
None
 1.48A 3abkA-4llsA:
2.0
3abkB-4llsA:
undetectable
3abkT-4llsA:
undetectable		 3abkA-4llsA:
20.31
3abkB-4llsA:
22.93
3abkT-4llsA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG3_B_CHDB1085_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		5 / 11 MET A 149
GLN A 175
THR A 172
ARG A  44
GLY A 184
 GST  A 302 ( 4.1A)
None
None
IPE  A 301 (-3.1A)
None
 1.41A 3ag3A-4llsA:
0.8
3ag3B-4llsA:
undetectable
3ag3T-4llsA:
undetectable		 3ag3A-4llsA:
20.31
3ag3B-4llsA:
22.93
3ag3T-4llsA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG3_B_CHDB1085_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		5 / 11 MET A 149
GLY A 148
GLN A 175
ARG A  44
GLY A 184
 GST  A 302 ( 4.1A)
None
None
IPE  A 301 (-3.1A)
None
 1.13A 3ag3A-4llsA:
0.8
3ag3B-4llsA:
undetectable
3ag3T-4llsA:
undetectable		 3ag3A-4llsA:
20.31
3ag3B-4llsA:
22.93
3ag3T-4llsA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG3_O_CHDO229_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		5 / 11 ARG A  44
GLY A 184
MET A 149
GLY A 148
GLN A 175
 IPE  A 301 (-3.1A)
None
GST  A 302 ( 4.1A)
None
None
 1.18A 3ag3G-4llsA:
undetectable
3ag3N-4llsA:
1.9
3ag3O-4llsA:
undetectable		 3ag3G-4llsA:
14.29
3ag3N-4llsA:
20.31
3ag3O-4llsA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG4_B_CHDB1085_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		5 / 12 MET A 149
GLY A 177
GLN A 175
ARG A  44
GLY A 184
 GST  A 302 ( 4.1A)
None
None
IPE  A 301 (-3.1A)
None
 1.41A 3ag4A-4llsA:
1.3
3ag4B-4llsA:
undetectable
3ag4T-4llsA:
undetectable		 3ag4A-4llsA:
20.31
3ag4B-4llsA:
22.93
3ag4T-4llsA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EZ3_A_ZOLA397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE, PUTATIVE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		5 / 9 ASP A  80
ARG A  91
GLN A 213
ASP A 216
LYS A 230
 CA  A 304 ( 2.9A)
GST  A 302 (-2.9A)
IPE  A 301 ( 4.1A)
CA  A 303 (-2.9A)
GST  A 302 (-2.7A)
 1.12A 3ez3A-4llsA:
28.4		 3ez3A-4llsA:
27.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EZ3_A_ZOLA397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE, PUTATIVE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		6 / 9 ASP A  80
ASP A  86
ARG A  91
GLN A 153
ASP A 216
LYS A 230
 CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
GST  A 302 (-3.7A)
CA  A 303 (-2.9A)
GST  A 302 (-2.7A)
 0.93A 3ez3A-4llsA:
28.4		 3ez3A-4llsA:
27.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EZ3_A_ZOLA397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE, PUTATIVE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		7 / 9 ASP A  80
ASP A  86
ARG A  91
LYS A 178
THR A 179
ASP A 216
LYS A 230
 CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
GST  A 302 (-3.4A)
IPE  A 301 (-4.2A)
CA  A 303 (-2.9A)
GST  A 302 (-2.7A)
 0.73A 3ez3A-4llsA:
28.4		 3ez3A-4llsA:
27.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EZ3_A_ZOLA397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE, PUTATIVE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		7 / 9 ASP A  80
ASP A  86
ARG A  91
THR A 179
GLN A 213
ASP A 216
LYS A 230
 CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
IPE  A 301 (-4.2A)
IPE  A 301 ( 4.1A)
CA  A 303 (-2.9A)
GST  A 302 (-2.7A)
 0.76A 3ez3A-4llsA:
28.4		 3ez3A-4llsA:
27.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EZ3_B_ZOLB397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE, PUTATIVE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		5 / 9 ASP A  80
ARG A  91
GLN A 213
ASP A 216
LYS A 230
 CA  A 304 ( 2.9A)
GST  A 302 (-2.9A)
IPE  A 301 ( 4.1A)
CA  A 303 (-2.9A)
GST  A 302 (-2.7A)
 1.15A 3ez3B-4llsA:
28.3		 3ez3B-4llsA:
27.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EZ3_B_ZOLB397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE, PUTATIVE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		6 / 9 ASP A  80
ASP A  86
ARG A  91
GLN A 153
ASP A 216
LYS A 230
 CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
GST  A 302 (-3.7A)
CA  A 303 (-2.9A)
GST  A 302 (-2.7A)
 0.81A 3ez3B-4llsA:
28.3		 3ez3B-4llsA:
27.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EZ3_B_ZOLB397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE, PUTATIVE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		7 / 9 ASP A  80
ASP A  86
ARG A  91
LYS A 178
THR A 179
ASP A 216
LYS A 230
 CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
GST  A 302 (-3.4A)
IPE  A 301 (-4.2A)
CA  A 303 (-2.9A)
GST  A 302 (-2.7A)
 0.66A 3ez3B-4llsA:
28.3		 3ez3B-4llsA:
27.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EZ3_B_ZOLB397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE, PUTATIVE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		7 / 9 ASP A  80
ASP A  86
ARG A  91
THR A 179
GLN A 213
ASP A 216
LYS A 230
 CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
IPE  A 301 (-4.2A)
IPE  A 301 ( 4.1A)
CA  A 303 (-2.9A)
GST  A 302 (-2.7A)
 0.68A 3ez3B-4llsA:
28.3		 3ez3B-4llsA:
27.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EZ3_C_ZOLC397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE, PUTATIVE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		5 / 9 ASP A  80
ARG A  91
GLN A 213
ASP A 216
LYS A 230
 CA  A 304 ( 2.9A)
GST  A 302 (-2.9A)
IPE  A 301 ( 4.1A)
CA  A 303 (-2.9A)
GST  A 302 (-2.7A)
 1.11A 3ez3C-4llsA:
27.8		 3ez3C-4llsA:
27.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EZ3_C_ZOLC397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE, PUTATIVE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		6 / 9 ASP A  80
ASP A  86
ARG A  91
GLN A 153
ASP A 216
LYS A 230
 CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
GST  A 302 (-3.7A)
CA  A 303 (-2.9A)
GST  A 302 (-2.7A)
 0.89A 3ez3C-4llsA:
27.8		 3ez3C-4llsA:
27.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EZ3_C_ZOLC397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE, PUTATIVE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		7 / 9 ASP A  80
ASP A  86
ARG A  91
LYS A 178
THR A 179
ASP A 216
LYS A 230
 CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
GST  A 302 (-3.4A)
IPE  A 301 (-4.2A)
CA  A 303 (-2.9A)
GST  A 302 (-2.7A)
 0.74A 3ez3C-4llsA:
27.8		 3ez3C-4llsA:
27.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EZ3_C_ZOLC397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE, PUTATIVE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		7 / 9 ASP A  80
ASP A  86
ARG A  91
THR A 179
GLN A 213
ASP A 216
LYS A 230
 CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
IPE  A 301 (-4.2A)
IPE  A 301 ( 4.1A)
CA  A 303 (-2.9A)
GST  A 302 (-2.7A)
 0.78A 3ez3C-4llsA:
27.8		 3ez3C-4llsA:
27.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EZ3_D_ZOLD397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE, PUTATIVE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		6 / 10 LEU A  77
ASP A  80
ASP A  86
ARG A  91
GLN A 153
LYS A 230
 None
CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
GST  A 302 (-3.7A)
GST  A 302 (-2.7A)
 0.65A 3ez3D-4llsA:
28.2		 3ez3D-4llsA:
27.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EZ3_D_ZOLD397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE, PUTATIVE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		8 / 10 LEU A  77
ASP A  80
ASP A  86
ARG A  91
LYS A 178
THR A 179
ASP A 216
LYS A 230
 None
CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
GST  A 302 (-3.4A)
IPE  A 301 (-4.2A)
CA  A 303 (-2.9A)
GST  A 302 (-2.7A)
 0.63A 3ez3D-4llsA:
28.2		 3ez3D-4llsA:
27.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EZ3_D_ZOLD397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE, PUTATIVE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		8 / 10 LEU A  77
ASP A  80
ASP A  86
ARG A  91
THR A 179
GLN A 213
ASP A 216
LYS A 230
 None
CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
IPE  A 301 (-4.2A)
IPE  A 301 ( 4.1A)
CA  A 303 (-2.9A)
GST  A 302 (-2.7A)
 0.65A 3ez3D-4llsA:
28.2		 3ez3D-4llsA:
27.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IBA_A_ZOLA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		6 / 10 ASP A  80
ASP A  86
ARG A  91
GLN A 153
ASP A 216
LYS A 230
 CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
GST  A 302 (-3.7A)
CA  A 303 (-2.9A)
GST  A 302 (-2.7A)
 0.82A 3ibaA-4llsA:
28.8		 3ibaA-4llsA:
26.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IBA_A_ZOLA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		8 / 10 ASP A  80
ASP A  86
ARG A  91
LYS A 178
THR A 179
GLN A 213
ASP A 216
LYS A 230
 CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
GST  A 302 (-3.4A)
IPE  A 301 (-4.2A)
IPE  A 301 ( 4.1A)
CA  A 303 (-2.9A)
GST  A 302 (-2.7A)
 0.72A 3ibaA-4llsA:
28.8		 3ibaA-4llsA:
26.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JAY_A_SAMA1102_1
(STRUCTURAL PROTEIN
VP3)		 5kd0 AROMATIC
PRENYLTRANSFERASE
(Aspergillus
terreus) 		3 / 3 ARG A 104
ASP A 182
ASP A 179
 GST  A 502 ( 3.4A)
None
GST  A 502 ( 4.4A)
 0.72A 3jayA-5kd0A:
undetectable		 3jayA-5kd0A:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB2_A_SAMA1102_1
(STRUCTURAL PROTEIN
VP3)		 5kd0 AROMATIC
PRENYLTRANSFERASE
(Aspergillus
terreus) 		3 / 3 ARG A 104
ASP A 182
ASP A 179
 GST  A 502 ( 3.4A)
None
GST  A 502 ( 4.4A)
 0.88A 3jb2A-5kd0A:
undetectable		 3jb2A-5kd0A:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LDW_A_ZOLA397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		5 / 9 ASP A  80
ARG A  91
GLN A 213
ASP A 216
LYS A 230
 CA  A 304 ( 2.9A)
GST  A 302 (-2.9A)
IPE  A 301 ( 4.1A)
CA  A 303 (-2.9A)
GST  A 302 (-2.7A)
 1.11A 3ldwA-4llsA:
28.3		 3ldwA-4llsA:
27.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LDW_A_ZOLA397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		6 / 9 ASP A  80
ASP A  86
ARG A  91
GLN A 153
ASP A 216
LYS A 230
 CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
GST  A 302 (-3.7A)
CA  A 303 (-2.9A)
GST  A 302 (-2.7A)
 0.94A 3ldwA-4llsA:
28.3		 3ldwA-4llsA:
27.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LDW_A_ZOLA397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		7 / 9 ASP A  80
ASP A  86
ARG A  91
LYS A 178
THR A 179
ASP A 216
LYS A 230
 CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
GST  A 302 (-3.4A)
IPE  A 301 (-4.2A)
CA  A 303 (-2.9A)
GST  A 302 (-2.7A)
 0.75A 3ldwA-4llsA:
28.3		 3ldwA-4llsA:
27.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LDW_A_ZOLA397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		7 / 9 ASP A  80
ASP A  86
ARG A  91
THR A 179
GLN A 213
ASP A 216
LYS A 230
 CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
IPE  A 301 (-4.2A)
IPE  A 301 ( 4.1A)
CA  A 303 (-2.9A)
GST  A 302 (-2.7A)
 0.78A 3ldwA-4llsA:
28.3		 3ldwA-4llsA:
27.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LDW_B_ZOLB397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		5 / 9 ASP A  80
ARG A  91
GLN A 213
ASP A 216
LYS A 230
 CA  A 304 ( 2.9A)
GST  A 302 (-2.9A)
IPE  A 301 ( 4.1A)
CA  A 303 (-2.9A)
GST  A 302 (-2.7A)
 1.20A 3ldwB-4llsA:
28.3		 3ldwB-4llsA:
27.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LDW_B_ZOLB397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		6 / 9 ASP A  80
ASP A  86
ARG A  91
GLN A 153
ASP A 216
LYS A 230
 CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
GST  A 302 (-3.7A)
CA  A 303 (-2.9A)
GST  A 302 (-2.7A)
 0.83A 3ldwB-4llsA:
28.3		 3ldwB-4llsA:
27.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LDW_B_ZOLB397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		7 / 9 ASP A  80
ASP A  86
ARG A  91
LYS A 178
THR A 179
ASP A 216
LYS A 230
 CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
GST  A 302 (-3.4A)
IPE  A 301 (-4.2A)
CA  A 303 (-2.9A)
GST  A 302 (-2.7A)
 0.69A 3ldwB-4llsA:
28.3		 3ldwB-4llsA:
27.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LDW_B_ZOLB397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		7 / 9 ASP A  80
ASP A  86
ARG A  91
THR A 179
GLN A 213
ASP A 216
LYS A 230
 CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
IPE  A 301 (-4.2A)
IPE  A 301 ( 4.1A)
CA  A 303 (-2.9A)
GST  A 302 (-2.7A)
 0.71A 3ldwB-4llsA:
28.3		 3ldwB-4llsA:
27.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LDW_C_ZOLC397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		6 / 9 ASP A  80
ASP A  86
ARG A  91
GLN A 153
ASP A 216
LYS A 230
 CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
GST  A 302 (-3.7A)
CA  A 303 (-2.9A)
GST  A 302 (-2.7A)
 0.90A 3ldwC-4llsA:
28.3		 3ldwC-4llsA:
27.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LDW_C_ZOLC397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		7 / 9 ASP A  80
ASP A  86
ARG A  91
LYS A 178
THR A 179
ASP A 216
LYS A 230
 CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
GST  A 302 (-3.4A)
IPE  A 301 (-4.2A)
CA  A 303 (-2.9A)
GST  A 302 (-2.7A)
 0.73A 3ldwC-4llsA:
28.3		 3ldwC-4llsA:
27.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LDW_C_ZOLC397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		7 / 9 ASP A  80
ASP A  86
ARG A  91
THR A 179
GLN A 213
ASP A 216
LYS A 230
 CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
IPE  A 301 (-4.2A)
IPE  A 301 ( 4.1A)
CA  A 303 (-2.9A)
GST  A 302 (-2.7A)
 0.77A 3ldwC-4llsA:
28.3		 3ldwC-4llsA:
27.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LDW_D_ZOLD397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		6 / 9 ASP A  80
ASP A  86
ARG A  91
GLN A 153
ASP A 216
LYS A 230
 CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
GST  A 302 (-3.7A)
CA  A 303 (-2.9A)
GST  A 302 (-2.7A)
 0.82A 3ldwD-4llsA:
28.2		 3ldwD-4llsA:
27.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LDW_D_ZOLD397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		7 / 9 ASP A  80
ASP A  86
ARG A  91
LYS A 178
THR A 179
ASP A 216
LYS A 230
 CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
GST  A 302 (-3.4A)
IPE  A 301 (-4.2A)
CA  A 303 (-2.9A)
GST  A 302 (-2.7A)
 0.68A 3ldwD-4llsA:
28.2		 3ldwD-4llsA:
27.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LDW_D_ZOLD397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		7 / 9 ASP A  80
ASP A  86
ARG A  91
THR A 179
GLN A 213
ASP A 216
LYS A 230
 CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
IPE  A 301 (-4.2A)
IPE  A 301 ( 4.1A)
CA  A 303 (-2.9A)
GST  A 302 (-2.7A)
 0.70A 3ldwD-4llsA:
28.2		 3ldwD-4llsA:
27.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N45_F_ZOLF354_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		7 / 11 LEU A  77
ASP A  80
ASP A  86
ARG A  91
GLN A 153
ASP A 216
LYS A 230
 None
CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
GST  A 302 (-3.7A)
CA  A 303 (-2.9A)
GST  A 302 (-2.7A)
 0.73A 3n45F-4llsA:
29.2		 3n45F-4llsA:
25.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N45_F_ZOLF354_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		9 / 11 LEU A  77
ASP A  80
ASP A  86
ARG A  91
LYS A 178
THR A 179
GLN A 213
ASP A 216
LYS A 230
 None
CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
GST  A 302 (-3.4A)
IPE  A 301 (-4.2A)
IPE  A 301 ( 4.1A)
CA  A 303 (-2.9A)
GST  A 302 (-2.7A)
 0.71A 3n45F-4llsA:
29.2		 3n45F-4llsA:
25.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N46_F_ZOLF354_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		7 / 10 LEU A  77
ASP A  80
ASP A  86
ARG A  91
GLN A 153
ASP A 216
LYS A 230
 None
CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
GST  A 302 (-3.7A)
CA  A 303 (-2.9A)
GST  A 302 (-2.7A)
 0.74A 3n46F-4llsA:
29.0		 3n46F-4llsA:
25.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N46_F_ZOLF354_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		9 / 10 LEU A  77
ASP A  80
ASP A  86
ARG A  91
LYS A 178
THR A 179
GLN A 213
ASP A 216
LYS A 230
 None
CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
GST  A 302 (-3.4A)
IPE  A 301 (-4.2A)
IPE  A 301 ( 4.1A)
CA  A 303 (-2.9A)
GST  A 302 (-2.7A)
 0.71A 3n46F-4llsA:
29.0		 3n46F-4llsA:
25.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NW2_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 3vc1 GERANYL DIPHOSPHATE
2-C-METHYLTRANSFERAS
E
(Streptomyces
coelicolor) 		3 / 3 ARG A 229
ILE A 226
TRP A 204
 None
GST  A 303 ( 4.9A)
None
 0.96A 3nw2A-3vc1A:
undetectable		 3nw2A-3vc1A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NW2_B_H4BB902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 3vc1 GERANYL DIPHOSPHATE
2-C-METHYLTRANSFERAS
E
(Streptomyces
coelicolor) 		3 / 3 ARG A 229
ILE A 226
TRP A 204
 None
GST  A 303 ( 4.9A)
None
 0.96A 3nw2B-3vc1A:
undetectable		 3nw2B-3vc1A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3THR_A_C2FA1100_1
(GLYCINE
N-METHYLTRANSFERASE)		 3v1v 2-METHYLISOBORNEOL
SYNTHASE
(Streptomyces
coelicolor) 		3 / 3 LEU A 274
HIS A 275
MET A 271
 GST  A 511 (-4.6A)
None
None
 0.70A 3thrD-3v1vA:
undetectable		 3thrD-3v1vA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WG7_B_CHDB303_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		5 / 11 MET A 149
GLY A 177
GLN A 175
ARG A  44
GLY A 184
 GST  A 302 ( 4.1A)
None
None
IPE  A 301 (-3.1A)
None
 1.45A 3wg7A-4llsA:
2.0
3wg7B-4llsA:
undetectable
3wg7T-4llsA:
undetectable		 3wg7A-4llsA:
20.31
3wg7B-4llsA:
22.93
3wg7T-4llsA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3X2Q_B_CHDB302_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		5 / 11 MET A 149
GLY A 177
GLN A 175
ARG A  44
GLY A 184
 GST  A 302 ( 4.1A)
None
None
IPE  A 301 (-3.1A)
None
 1.47A 3x2qA-4llsA:
0.6
3x2qB-4llsA:
undetectable
3x2qT-4llsA:
undetectable		 3x2qA-4llsA:
20.31
3x2qB-4llsA:
22.93
3x2qT-4llsA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AFT_A_QMRA301_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 3v1v 2-METHYLISOBORNEOL
SYNTHASE
(Streptomyces
coelicolor) 		5 / 10 TYR A 248
VAL A 191
CYH A 308
VAL A 166
MET A 170
 None
None
GST  A 511 (-3.4A)
None
None
 1.22A 4aftA-3v1vA:
undetectable
4aftB-3v1vA:
undetectable		 4aftA-3v1vA:
18.08
4aftB-3v1vA:
18.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AFT_B_QMRB301_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 3v1v 2-METHYLISOBORNEOL
SYNTHASE
(Streptomyces
coelicolor) 		5 / 9 TYR A 248
VAL A 191
CYH A 308
VAL A 166
MET A 170
 None
None
GST  A 511 (-3.4A)
None
None
 1.31A 4aftB-3v1vA:
undetectable
4aftC-3v1vA:
undetectable		 4aftB-3v1vA:
18.08
4aftC-3v1vA:
18.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AFT_E_QMRE301_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 3v1v 2-METHYLISOBORNEOL
SYNTHASE
(Streptomyces
coelicolor) 		5 / 10 VAL A 166
MET A 170
TYR A 248
VAL A 191
CYH A 308
 None
None
None
None
GST  A 511 (-3.4A)
 1.23A 4aftA-3v1vA:
undetectable
4aftE-3v1vA:
undetectable		 4aftA-3v1vA:
18.08
4aftE-3v1vA:
18.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AWU_A_4CHA502_0
(OXIDOREDUCTASE,
FMN-BINDING)		 3v1v 2-METHYLISOBORNEOL
SYNTHASE
(Streptomyces
coelicolor) 		4 / 7 THR A 342
ASN A 362
TYR A 296
PHE A 305
 GST  A 511 ( 4.4A)
None
None
GST  A 511 (-3.5A)
 1.32A 4awuA-3v1vA:
undetectable		 4awuA-3v1vA:
24.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BVA_A_T3A1314_1
(THIOMORPHOLINE-CARBO
XYLATE DEHYDROGENASE)		 4od5 4-HYDROXYBENZOATE
OCTAPRENYLTRANSFERAS
E
(Aeropyrum
pernix) 		5 / 12 VAL A 171
GLY A 130
VAL A 132
SER A  12
PRO A 265
 None
None
PHB  A 302 (-4.6A)
GST  A 301 ( 4.1A)
None
 1.42A 4bvaA-4od5A:
undetectable		 4bvaA-4od5A:
24.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KFA_A_ZOLA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		8 / 9 LEU A  77
ASP A  80
ASP A  86
ARG A  91
GLN A 153
LYS A 178
ASP A 216
LYS A 230
 None
CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
GST  A 302 (-3.7A)
GST  A 302 (-3.4A)
CA  A 303 (-2.9A)
GST  A 302 (-2.7A)
 0.81A 4kfaA-4llsA:
29.1		 4kfaA-4llsA:
29.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KFA_A_ZOLA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		7 / 9 LEU A  77
ASP A  80
ASP A  86
ARG A  91
GLN A 213
ASP A 216
LYS A 230
 None
CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
IPE  A 301 ( 4.1A)
CA  A 303 (-2.9A)
GST  A 302 (-2.7A)
 0.63A 4kfaA-4llsA:
29.1		 4kfaA-4llsA:
29.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KPD_A_RISA405_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		7 / 10 LEU A  77
ASP A  80
ASP A  86
ARG A  91
GLN A 153
ASP A 216
LYS A 230
 None
CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
GST  A 302 (-3.7A)
CA  A 303 (-2.9A)
GST  A 302 (-2.7A)
 0.74A 4kpdA-4llsA:
30.3		 4kpdA-4llsA:
29.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KPD_A_RISA405_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		9 / 10 LEU A  77
ASP A  80
ASP A  86
ARG A  91
LYS A 178
THR A 179
GLN A 213
ASP A 216
LYS A 230
 None
CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
GST  A 302 (-3.4A)
IPE  A 301 (-4.2A)
IPE  A 301 ( 4.1A)
CA  A 303 (-2.9A)
GST  A 302 (-2.7A)
 0.69A 4kpdA-4llsA:
30.3		 4kpdA-4llsA:
29.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KPJ_A_210A901_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		9 / 9 LEU A  77
ASP A  80
ASP A  86
ARG A  91
LYS A 178
THR A 179
GLN A 213
ASP A 216
LYS A 230
 None
CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
GST  A 302 (-3.4A)
IPE  A 301 (-4.2A)
IPE  A 301 ( 4.1A)
CA  A 303 (-2.9A)
GST  A 302 (-2.7A)
 0.71A 4kpjA-4llsA:
29.2		 4kpjA-4llsA:
29.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KQ5_A_ZOLA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		5 / 10 ASP A  80
ARG A  91
GLN A 213
ASP A 216
LYS A 230
 CA  A 304 ( 2.9A)
GST  A 302 (-2.9A)
IPE  A 301 ( 4.1A)
CA  A 303 (-2.9A)
GST  A 302 (-2.7A)
 1.21A 4kq5A-4llsA:
29.2		 4kq5A-4llsA:
29.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KQ5_A_ZOLA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		7 / 10 LEU A  77
ASP A  80
ASP A  86
ARG A  91
GLN A 153
ASP A 216
LYS A 230
 None
CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
GST  A 302 (-3.7A)
CA  A 303 (-2.9A)
GST  A 302 (-2.7A)
 0.77A 4kq5A-4llsA:
29.2		 4kq5A-4llsA:
29.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KQ5_A_ZOLA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		9 / 10 LEU A  77
ASP A  80
ASP A  86
ARG A  91
LYS A 178
THR A 179
GLN A 213
ASP A 216
LYS A 230
 None
CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
GST  A 302 (-3.4A)
IPE  A 301 (-4.2A)
IPE  A 301 ( 4.1A)
CA  A 303 (-2.9A)
GST  A 302 (-2.7A)
 0.76A 4kq5A-4llsA:
29.2		 4kq5A-4llsA:
29.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KQS_A_RISA405_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		7 / 10 LEU A  77
ASP A  80
ASP A  86
ARG A  91
GLN A 153
ASP A 216
LYS A 230
 None
CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
GST  A 302 (-3.7A)
CA  A 303 (-2.9A)
GST  A 302 (-2.7A)
 0.72A 4kqsA-4llsA:
30.3		 4kqsA-4llsA:
29.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KQS_A_RISA405_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		9 / 10 LEU A  77
ASP A  80
ASP A  86
ARG A  91
LYS A 178
THR A 179
GLN A 213
ASP A 216
LYS A 230
 None
CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
GST  A 302 (-3.4A)
IPE  A 301 (-4.2A)
IPE  A 301 ( 4.1A)
CA  A 303 (-2.9A)
GST  A 302 (-2.7A)
 0.68A 4kqsA-4llsA:
30.3		 4kqsA-4llsA:
29.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M11_C_MXMC606_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3v1v 2-METHYLISOBORNEOL
SYNTHASE
(Streptomyces
coelicolor) 		3 / 3 LEU A 274
ARG A 273
MET A 330
 GST  A 511 (-4.6A)
None
None
 0.96A 4m11C-3v1vA:
undetectable		 4m11C-3v1vA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N9U_A_RISA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		7 / 10 LEU A  77
ASP A  80
ASP A  86
ARG A  91
GLN A 153
ASP A 216
LYS A 230
 None
CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
GST  A 302 (-3.7A)
CA  A 303 (-2.9A)
GST  A 302 (-2.7A)
 0.75A 4n9uA-4llsA:
29.0		 4n9uA-4llsA:
29.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N9U_A_RISA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		8 / 10 LEU A  77
ASP A  80
ASP A  86
ARG A  91
THR A 179
GLN A 213
ASP A 216
LYS A 230
 None
CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
IPE  A 301 (-4.2A)
IPE  A 301 ( 4.1A)
CA  A 303 (-2.9A)
GST  A 302 (-2.7A)
 0.62A 4n9uA-4llsA:
29.0		 4n9uA-4llsA:
29.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NG6_A_RISA405_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		5 / 12 ASP A  80
ARG A  91
GLN A 213
ASP A 216
LYS A 230
 CA  A 304 ( 2.9A)
GST  A 302 (-2.9A)
IPE  A 301 ( 4.1A)
CA  A 303 (-2.9A)
GST  A 302 (-2.7A)
 1.19A 4ng6A-4llsA:
29.7		 4ng6A-4llsA:
29.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NG6_A_RISA405_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		9 / 12 LEU A  77
ASP A  80
ASP A  86
ARG A  91
GLN A 153
THR A 179
GLN A 213
ASP A 216
LYS A 230
 None
CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
GST  A 302 (-3.7A)
IPE  A 301 (-4.2A)
IPE  A 301 ( 4.1A)
CA  A 303 (-2.9A)
GST  A 302 (-2.7A)
 0.62A 4ng6A-4llsA:
29.7		 4ng6A-4llsA:
29.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKE_A_RISA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		7 / 10 LEU A  77
ASP A  80
ASP A  86
ARG A  91
GLN A 153
ASP A 216
LYS A 230
 None
CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
GST  A 302 (-3.7A)
CA  A 303 (-2.9A)
GST  A 302 (-2.7A)
 0.78A 4nkeA-4llsA:
29.0		 4nkeA-4llsA:
29.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKE_A_RISA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		8 / 10 LEU A  77
ASP A  80
ASP A  86
ARG A  91
LYS A 178
THR A 179
ASP A 216
LYS A 230
 None
CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
GST  A 302 (-3.4A)
IPE  A 301 (-4.2A)
CA  A 303 (-2.9A)
GST  A 302 (-2.7A)
 0.69A 4nkeA-4llsA:
29.0		 4nkeA-4llsA:
29.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKE_A_RISA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		8 / 10 LEU A  77
ASP A  80
ASP A  86
ARG A  91
THR A 179
GLN A 213
ASP A 216
LYS A 230
 None
CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
IPE  A 301 (-4.2A)
IPE  A 301 ( 4.1A)
CA  A 303 (-2.9A)
GST  A 302 (-2.7A)
 0.69A 4nkeA-4llsA:
29.0		 4nkeA-4llsA:
29.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKF_A_210A404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		9 / 9 LEU A  77
ASP A  80
ASP A  86
ARG A  91
LYS A 178
THR A 179
GLN A 213
ASP A 216
LYS A 230
 None
CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
GST  A 302 (-3.4A)
IPE  A 301 (-4.2A)
IPE  A 301 ( 4.1A)
CA  A 303 (-2.9A)
GST  A 302 (-2.7A)
 0.66A 4nkfA-4llsA:
29.3		 4nkfA-4llsA:
29.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NUA_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		7 / 10 LEU A  77
ASP A  80
ASP A  86
ARG A  91
GLN A 153
ASP A 216
LYS A 230
 None
CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
GST  A 302 (-3.7A)
CA  A 303 (-2.9A)
GST  A 302 (-2.7A)
 0.84A 4nuaA-4llsA:
29.4		 4nuaA-4llsA:
29.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NUA_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		9 / 10 LEU A  77
ASP A  80
ASP A  86
ARG A  91
LYS A 178
THR A 179
GLN A 213
ASP A 216
LYS A 230
 None
CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
GST  A 302 (-3.4A)
IPE  A 301 (-4.2A)
IPE  A 301 ( 4.1A)
CA  A 303 (-2.9A)
GST  A 302 (-2.7A)
 0.79A 4nuaA-4llsA:
29.4		 4nuaA-4llsA:
29.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OGU_A_210A405_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		9 / 9 LEU A  77
ASP A  80
ASP A  86
ARG A  91
LYS A 178
THR A 179
GLN A 213
ASP A 216
LYS A 230
 None
CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
GST  A 302 (-3.4A)
IPE  A 301 (-4.2A)
IPE  A 301 ( 4.1A)
CA  A 303 (-2.9A)
GST  A 302 (-2.7A)
 0.70A 4oguA-4llsA:
29.1		 4oguA-4llsA:
29.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P0V_A_ZOLA401_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		6 / 9 ASP A  80
ASP A  86
ARG A  91
GLN A 153
ASP A 216
LYS A 230
 CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
GST  A 302 (-3.7A)
CA  A 303 (-2.9A)
GST  A 302 (-2.7A)
 0.74A 4p0vA-4llsA:
30.2		 4p0vA-4llsA:
25.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P0V_A_ZOLA401_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		8 / 9 ASP A  80
ASP A  86
ARG A  91
LYS A 178
THR A 179
GLN A 213
ASP A 216
LYS A 230
 CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
GST  A 302 (-3.4A)
IPE  A 301 (-4.2A)
IPE  A 301 ( 4.1A)
CA  A 303 (-2.9A)
GST  A 302 (-2.7A)
 0.75A 4p0vA-4llsA:
30.2		 4p0vA-4llsA:
25.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P0W_A_ZOLA501_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		5 / 11 ASP A  80
ARG A  91
GLN A 213
ASP A 216
LYS A 230
 CA  A 304 ( 2.9A)
GST  A 302 (-2.9A)
IPE  A 301 ( 4.1A)
CA  A 303 (-2.9A)
GST  A 302 (-2.7A)
 1.18A 4p0wA-4llsA:
30.0		 4p0wA-4llsA:
25.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P0W_A_ZOLA501_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		7 / 11 LEU A  77
ASP A  80
ASP A  86
ARG A  91
GLN A 153
ASP A 216
LYS A 230
 None
CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
GST  A 302 (-3.7A)
CA  A 303 (-2.9A)
GST  A 302 (-2.7A)
 0.74A 4p0wA-4llsA:
30.0		 4p0wA-4llsA:
25.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P0W_A_ZOLA501_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		9 / 11 LEU A  77
ASP A  80
ASP A  86
ARG A  91
LYS A 178
THR A 179
GLN A 213
ASP A 216
LYS A 230
 None
CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
GST  A 302 (-3.4A)
IPE  A 301 (-4.2A)
IPE  A 301 ( 4.1A)
CA  A 303 (-2.9A)
GST  A 302 (-2.7A)
 0.74A 4p0wA-4llsA:
30.0		 4p0wA-4llsA:
25.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q23_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		8 / 10 LEU A  77
ASP A  80
ASP A  86
ARG A  91
GLN A 153
LYS A 178
ASP A 216
LYS A 230
 None
CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
GST  A 302 (-3.7A)
GST  A 302 (-3.4A)
CA  A 303 (-2.9A)
GST  A 302 (-2.7A)
 0.79A 4q23A-4llsA:
28.7		 4q23A-4llsA:
29.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q23_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		8 / 10 LEU A  77
ASP A  80
ASP A  86
ARG A  91
LYS A 178
GLN A 213
ASP A 216
LYS A 230
 None
CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
GST  A 302 (-3.4A)
IPE  A 301 ( 4.1A)
CA  A 303 (-2.9A)
GST  A 302 (-2.7A)
 0.70A 4q23A-4llsA:
28.7		 4q23A-4llsA:
29.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RXD_A_RISA1404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		7 / 10 LEU A  77
ASP A  80
ASP A  86
ARG A  91
GLN A 153
ASP A 216
LYS A 230
 None
CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
GST  A 302 (-3.7A)
CA  A 303 (-2.9A)
GST  A 302 (-2.7A)
 0.75A 4rxdA-4llsA:
27.7		 4rxdA-4llsA:
27.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RXD_A_RISA1404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		9 / 10 LEU A  77
ASP A  80
ASP A  86
ARG A  91
LYS A 178
THR A 179
GLN A 213
ASP A 216
LYS A 230
 None
CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
GST  A 302 (-3.4A)
IPE  A 301 (-4.2A)
IPE  A 301 ( 4.1A)
CA  A 303 (-2.9A)
GST  A 302 (-2.7A)
 0.69A 4rxdA-4llsA:
27.7		 4rxdA-4llsA:
27.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RXD_B_RISB1504_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		7 / 10 LEU A  77
ASP A  80
ASP A  86
ARG A  91
GLN A 153
ASP A 216
LYS A 230
 None
CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
GST  A 302 (-3.7A)
CA  A 303 (-2.9A)
GST  A 302 (-2.7A)
 0.73A 4rxdB-4llsA:
28.0		 4rxdB-4llsA:
27.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RXD_B_RISB1504_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		9 / 10 LEU A  77
ASP A  80
ASP A  86
ARG A  91
LYS A 178
THR A 179
GLN A 213
ASP A 216
LYS A 230
 None
CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
GST  A 302 (-3.4A)
IPE  A 301 (-4.2A)
IPE  A 301 ( 4.1A)
CA  A 303 (-2.9A)
GST  A 302 (-2.7A)
 0.68A 4rxdB-4llsA:
28.0		 4rxdB-4llsA:
27.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RXD_C_RISC1600_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		7 / 10 LEU A  77
ASP A  80
ASP A  86
ARG A  91
GLN A 153
ASP A 216
LYS A 230
 None
CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
GST  A 302 (-3.7A)
CA  A 303 (-2.9A)
GST  A 302 (-2.7A)
 0.74A 4rxdC-4llsA:
28.0		 4rxdC-4llsA:
27.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RXD_C_RISC1600_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		9 / 10 LEU A  77
ASP A  80
ASP A  86
ARG A  91
LYS A 178
THR A 179
GLN A 213
ASP A 216
LYS A 230
 None
CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
GST  A 302 (-3.4A)
IPE  A 301 (-4.2A)
IPE  A 301 ( 4.1A)
CA  A 303 (-2.9A)
GST  A 302 (-2.7A)
 0.68A 4rxdC-4llsA:
28.0		 4rxdC-4llsA:
27.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4UMJ_A_BFQA1297_1
(GERANYLTRANSTRANSFER
ASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		8 / 8 SER A  76
LEU A  77
ASP A  80
ASP A  86
ARG A  91
MET A 149
GLN A 153
LYS A 178
 GST  A 302 (-3.9A)
None
CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
GST  A 302 ( 4.1A)
GST  A 302 (-3.7A)
GST  A 302 (-3.4A)
 0.35A 4umjA-4llsA:
34.9		 4umjA-4llsA:
43.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4UMJ_B_BFQB1294_1
(GERANYLTRANSTRANSFER
ASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		9 / 9 SER A  76
LEU A  77
ASP A  80
ASP A  86
ARG A  91
MET A 149
GLN A 153
LYS A 178
THR A 179
 GST  A 302 (-3.9A)
None
CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
GST  A 302 ( 4.1A)
GST  A 302 (-3.7A)
GST  A 302 (-3.4A)
IPE  A 301 (-4.2A)
 0.45A 4umjB-4llsA:
35.4		 4umjB-4llsA:
43.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AIN_A_QMRA1207_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 3v1v 2-METHYLISOBORNEOL
SYNTHASE
(Streptomyces
coelicolor) 		5 / 10 TYR A 248
VAL A 191
CYH A 308
VAL A 166
MET A 170
 None
None
GST  A 511 (-3.4A)
None
None
 1.31A 5ainA-3v1vA:
undetectable
5ainB-3v1vA:
undetectable		 5ainA-3v1vA:
17.01
5ainB-3v1vA:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AIN_B_QMRB1207_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 3v1v 2-METHYLISOBORNEOL
SYNTHASE
(Streptomyces
coelicolor) 		5 / 10 TYR A 248
VAL A 191
CYH A 308
VAL A 166
MET A 170
 None
None
GST  A 511 (-3.4A)
None
None
 1.29A 5ainB-3v1vA:
undetectable
5ainC-3v1vA:
undetectable		 5ainB-3v1vA:
17.01
5ainC-3v1vA:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AIN_C_QMRC1207_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 3v1v 2-METHYLISOBORNEOL
SYNTHASE
(Streptomyces
coelicolor) 		5 / 10 TYR A 248
VAL A 191
CYH A 308
VAL A 166
MET A 170
 None
None
GST  A 511 (-3.4A)
None
None
 1.25A 5ainC-3v1vA:
undetectable
5ainD-3v1vA:
undetectable		 5ainC-3v1vA:
17.01
5ainD-3v1vA:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AIN_D_QMRD1207_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 3v1v 2-METHYLISOBORNEOL
SYNTHASE
(Streptomyces
coelicolor) 		5 / 10 TYR A 248
VAL A 191
CYH A 308
VAL A 166
MET A 170
 None
None
GST  A 511 (-3.4A)
None
None
 1.30A 5ainD-3v1vA:
undetectable
5ainE-3v1vA:
undetectable		 5ainD-3v1vA:
17.01
5ainE-3v1vA:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AIN_E_QMRE1207_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 3v1v 2-METHYLISOBORNEOL
SYNTHASE
(Streptomyces
coelicolor) 		5 / 10 VAL A 166
MET A 170
TYR A 248
VAL A 191
CYH A 308
 None
None
None
None
GST  A 511 (-3.4A)
 1.27A 5ainA-3v1vA:
undetectable
5ainE-3v1vA:
undetectable		 5ainA-3v1vA:
17.01
5ainE-3v1vA:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1A_B_CHDB303_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		5 / 11 MET A 149
GLY A 177
GLN A 175
ARG A  44
GLY A 184
 GST  A 302 ( 4.1A)
None
None
IPE  A 301 (-3.1A)
None
 1.47A 5b1aA-4llsA:
2.2
5b1aB-4llsA:
undetectable
5b1aT-4llsA:
undetectable		 5b1aA-4llsA:
20.31
5b1aB-4llsA:
22.93
5b1aT-4llsA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1B_B_CHDB303_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		5 / 11 MET A 149
GLY A 177
GLN A 175
ARG A  44
GLY A 184
 GST  A 302 ( 4.1A)
None
None
IPE  A 301 (-3.1A)
None
 1.32A 5b1bA-4llsA:
2.0
5b1bB-4llsA:
undetectable
5b1bT-4llsA:
undetectable		 5b1bA-4llsA:
20.31
5b1bB-4llsA:
22.93
5b1bT-4llsA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1B_G_CHDG103_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		5 / 11 ARG A  44
GLY A 184
MET A 149
GLY A 148
GLN A 175
 IPE  A 301 (-3.1A)
None
GST  A 302 ( 4.1A)
None
None
 1.34A 5b1bG-4llsA:
undetectable
5b1bN-4llsA:
1.5
5b1bO-4llsA:
undetectable		 5b1bG-4llsA:
14.29
5b1bN-4llsA:
20.31
5b1bO-4llsA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B3S_B_CHDB304_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		5 / 11 MET A 149
GLY A 177
GLN A 175
ARG A  44
GLY A 184
 GST  A 302 ( 4.1A)
None
None
IPE  A 301 (-3.1A)
None
 1.48A 5b3sA-4llsA:
1.9
5b3sB-4llsA:
undetectable
5b3sT-4llsA:
undetectable		 5b3sA-4llsA:
20.31
5b3sB-4llsA:
22.93
5b3sT-4llsA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CG5_A_RISA400_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		7 / 12 LEU A  77
ASP A  80
ASP A  86
ARG A  91
GLN A 153
ASP A 216
LYS A 230
 None
CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
GST  A 302 (-3.7A)
CA  A 303 (-2.9A)
GST  A 302 (-2.7A)
 0.69A 5cg5A-4llsA:
28.5		 5cg5A-4llsA:
25.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CG5_A_RISA400_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		9 / 12 LEU A  77
ASP A  80
ASP A  86
ARG A  91
LYS A 178
THR A 179
GLN A 213
ASP A 216
LYS A 230
 None
CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
GST  A 302 (-3.4A)
IPE  A 301 (-4.2A)
IPE  A 301 ( 4.1A)
CA  A 303 (-2.9A)
GST  A 302 (-2.7A)
 0.67A 5cg5A-4llsA:
28.5		 5cg5A-4llsA:
25.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CG6_A_RISA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		7 / 12 LEU A  77
ASP A  80
ASP A  86
ARG A  91
GLN A 153
ASP A 216
LYS A 230
 None
CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
GST  A 302 (-3.7A)
CA  A 303 (-2.9A)
GST  A 302 (-2.7A)
 0.71A 5cg6A-4llsA:
29.2		 5cg6A-4llsA:
25.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CG6_A_RISA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		9 / 12 LEU A  77
ASP A  80
ASP A  86
ARG A  91
LYS A 178
THR A 179
GLN A 213
ASP A 216
LYS A 230
 None
CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
GST  A 302 (-3.4A)
IPE  A 301 (-4.2A)
IPE  A 301 ( 4.1A)
CA  A 303 (-2.9A)
GST  A 302 (-2.7A)
 0.68A 5cg6A-4llsA:
29.2		 5cg6A-4llsA:
25.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZ2_A_212A404_1
(GERMACRADIENOL/GEOSM
IN SYNTHASE)		 3v1v 2-METHYLISOBORNEOL
SYNTHASE
(Streptomyces
coelicolor) 		6 / 9 ARG A 300
ASN A 345
SER A 349
GLU A 353
ARG A 433
TYR A 434
 GST  A 511 (-3.4A)
MG  A 501 ( 2.7A)
MG  A 501 ( 2.3A)
MG  A 501 ( 2.6A)
GST  A 511 (-3.9A)
GST  A 511 (-4.6A)
 0.65A 5dz2A-3v1vA:
32.1		 5dz2A-3v1vA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZ2_A_212A404_1
(GERMACRADIENOL/GEOSM
IN SYNTHASE)		 3v1v 2-METHYLISOBORNEOL
SYNTHASE
(Streptomyces
coelicolor) 		5 / 9 ASP A 197
ARG A 300
ASN A 345
SER A 349
GLU A 353
 MG  A 502 ( 3.7A)
GST  A 511 (-3.4A)
MG  A 501 ( 2.7A)
MG  A 501 ( 2.3A)
MG  A 501 ( 2.6A)
 0.93A 5dz2A-3v1vA:
32.1		 5dz2A-3v1vA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZ2_B_212B404_1
(GERMACRADIENOL/GEOSM
IN SYNTHASE)		 3v1v 2-METHYLISOBORNEOL
SYNTHASE
(Streptomyces
coelicolor) 		6 / 9 ARG A 300
ASN A 345
SER A 349
GLU A 353
ARG A 433
TYR A 434
 GST  A 511 (-3.4A)
MG  A 501 ( 2.7A)
MG  A 501 ( 2.3A)
MG  A 501 ( 2.6A)
GST  A 511 (-3.9A)
GST  A 511 (-4.6A)
 0.69A 5dz2B-3v1vA:
32.0		 5dz2B-3v1vA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERM_A_210A401_1
(FUSICOCCADIENE
SYNTHASE)		 3v1v 2-METHYLISOBORNEOL
SYNTHASE
(Streptomyces
coelicolor) 		6 / 10 ARG A 300
ASN A 345
SER A 349
GLU A 353
ARG A 433
TYR A 434
 GST  A 511 (-3.4A)
MG  A 501 ( 2.7A)
MG  A 501 ( 2.3A)
MG  A 501 ( 2.6A)
GST  A 511 (-3.9A)
GST  A 511 (-4.6A)
 0.66A 5ermA-3v1vA:
6.3		 5ermA-3v1vA:
24.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERM_A_210A401_1
(FUSICOCCADIENE
SYNTHASE)		 3v1v 2-METHYLISOBORNEOL
SYNTHASE
(Streptomyces
coelicolor) 		6 / 10 ASN A 345
SER A 349
LYS A 352
GLU A 353
ARG A 433
TYR A 434
 MG  A 501 ( 2.7A)
MG  A 501 ( 2.3A)
GST  A 511 (-3.1A)
MG  A 501 ( 2.6A)
GST  A 511 (-3.9A)
GST  A 511 (-4.6A)
 0.68A 5ermA-3v1vA:
6.3		 5ermA-3v1vA:
24.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERM_A_210A401_1
(FUSICOCCADIENE
SYNTHASE)		 3v1v 2-METHYLISOBORNEOL
SYNTHASE
(Streptomyces
coelicolor) 		5 / 10 ASP A 197
ARG A 300
ASN A 345
ARG A 433
TYR A 434
 MG  A 502 ( 3.7A)
GST  A 511 (-3.4A)
MG  A 501 ( 2.7A)
GST  A 511 (-3.9A)
GST  A 511 (-4.6A)
 1.41A 5ermA-3v1vA:
6.3		 5ermA-3v1vA:
24.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERM_B_210B704_1
(FUSICOCCADIENE
SYNTHASE)		 3v1v 2-METHYLISOBORNEOL
SYNTHASE
(Streptomyces
coelicolor) 		6 / 9 ARG A 300
ASN A 345
SER A 349
GLU A 353
ARG A 433
TYR A 434
 GST  A 511 (-3.4A)
MG  A 501 ( 2.7A)
MG  A 501 ( 2.3A)
MG  A 501 ( 2.6A)
GST  A 511 (-3.9A)
GST  A 511 (-4.6A)
 0.66A 5ermB-3v1vA:
10.5		 5ermB-3v1vA:
24.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERM_B_210B704_1
(FUSICOCCADIENE
SYNTHASE)		 3v1v 2-METHYLISOBORNEOL
SYNTHASE
(Streptomyces
coelicolor) 		6 / 9 ASN A 345
SER A 349
LYS A 352
GLU A 353
ARG A 433
TYR A 434
 MG  A 501 ( 2.7A)
MG  A 501 ( 2.3A)
GST  A 511 (-3.1A)
MG  A 501 ( 2.6A)
GST  A 511 (-3.9A)
GST  A 511 (-4.6A)
 0.65A 5ermB-3v1vA:
10.5		 5ermB-3v1vA:
24.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERO_A_210A804_1
(FUSICOCCADIENE
SYNTHASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		5 / 9 LEU A  77
ARG A  91
LYS A 178
GLN A 213
LYS A 230
 None
GST  A 302 (-2.9A)
GST  A 302 (-3.4A)
IPE  A 301 ( 4.1A)
GST  A 302 (-2.7A)
 1.46A 5eroA-4llsA:
24.7		 5eroA-4llsA:
28.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERO_A_210A804_1
(FUSICOCCADIENE
SYNTHASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		6 / 9 LEU A  77
ASP A  80
ASP A  86
ARG A  91
LYS A 178
ASP A 216
 None
CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
GST  A 302 (-3.4A)
CA  A 303 (-2.9A)
 0.72A 5eroA-4llsA:
24.7		 5eroA-4llsA:
28.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERO_A_210A804_1
(FUSICOCCADIENE
SYNTHASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		6 / 9 LEU A  77
ASP A  86
ARG A  91
LYS A 178
GLN A 213
ASP A 216
 None
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
GST  A 302 (-3.4A)
IPE  A 301 ( 4.1A)
CA  A 303 (-2.9A)
 0.84A 5eroA-4llsA:
24.7		 5eroA-4llsA:
28.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERO_B_210B804_1
(FUSICOCCADIENE
SYNTHASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		5 / 9 ASP A  80
ASP A  86
ARG A  91
LYS A 178
ASP A 216
 CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
GST  A 302 (-3.4A)
CA  A 303 (-2.9A)
 0.73A 5eroB-4llsA:
24.3		 5eroB-4llsA:
28.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERO_B_210B804_1
(FUSICOCCADIENE
SYNTHASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		5 / 9 ASP A  86
ARG A  91
LYS A 178
GLN A 213
ASP A 216
 CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
GST  A 302 (-3.4A)
IPE  A 301 ( 4.1A)
CA  A 303 (-2.9A)
 0.89A 5eroB-4llsA:
24.3		 5eroB-4llsA:
28.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERO_C_210C804_1
(FUSICOCCADIENE
SYNTHASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		5 / 10 ASP A  80
ASP A  81
ASP A  86
ARG A  91
ASP A 235
 CA  A 304 ( 2.9A)
None
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
CA  A 303 ( 4.3A)
 1.07A 5eroC-4llsA:
24.5		 5eroC-4llsA:
28.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERO_C_210C804_1
(FUSICOCCADIENE
SYNTHASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		6 / 10 ASP A  80
ASP A  81
ASP A  86
ARG A  91
LYS A 178
ASP A 216
 CA  A 304 ( 2.9A)
None
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
GST  A 302 (-3.4A)
CA  A 303 (-2.9A)
 0.69A 5eroC-4llsA:
24.5		 5eroC-4llsA:
28.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERO_C_210C804_1
(FUSICOCCADIENE
SYNTHASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		6 / 10 ASP A  81
ASP A  86
ARG A  91
LYS A 178
GLN A 213
ASP A 216
 None
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
GST  A 302 (-3.4A)
IPE  A 301 ( 4.1A)
CA  A 303 (-2.9A)
 0.79A 5eroC-4llsA:
24.5		 5eroC-4llsA:
28.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERO_C_210C804_1
(FUSICOCCADIENE
SYNTHASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		5 / 10 ASP A  86
ARG A  91
LYS A 178
GLN A 213
LYS A 230
 CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
GST  A 302 (-3.4A)
IPE  A 301 ( 4.1A)
GST  A 302 (-2.7A)
 1.28A 5eroC-4llsA:
24.5		 5eroC-4llsA:
28.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O87_A_NCTA601_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 3v1v 2-METHYLISOBORNEOL
SYNTHASE
(Streptomyces
coelicolor) 		5 / 10 TYR A 248
VAL A 191
CYH A 308
VAL A 166
MET A 170
 None
None
GST  A 511 (-3.4A)
None
None
 1.32A 5o87A-3v1vA:
undetectable
5o87B-3v1vA:
undetectable		 5o87A-3v1vA:
11.11
5o87B-3v1vA:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCG_A_08YA602_1
(CYTOCHROME P450 3A4)		 3vc1 GERANYL DIPHOSPHATE
2-C-METHYLTRANSFERAS
E
(Streptomyces
coelicolor) 		5 / 12 PHE A 273
ILE A 269
PHE A 282
THR A 250
ALA A 220
 None
None
GST  A 303 (-4.9A)
None
None
 1.10A 5vcgA-3vc1A:
undetectable		 5vcgA-3vc1A:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1B_O_CHDO302_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		5 / 11 ARG A  44
GLY A 184
MET A 149
GLY A 148
THR A 172
 IPE  A 301 (-3.1A)
None
GST  A 302 ( 4.1A)
None
None
 1.41A 5x1bG-4llsA:
undetectable
5x1bN-4llsA:
1.6
5x1bO-4llsA:
undetectable		 5x1bG-4llsA:
14.29
5x1bN-4llsA:
20.31
5x1bO-4llsA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1F_G_CHDG104_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		5 / 11 ARG A  44
GLY A 184
MET A 149
GLY A 177
GLN A 175
 IPE  A 301 (-3.1A)
None
GST  A 302 ( 4.1A)
None
None
 1.44A 5x1fG-4llsA:
undetectable
5x1fN-4llsA:
1.9
5x1fO-4llsA:
undetectable		 5x1fG-4llsA:
14.29
5x1fN-4llsA:
20.31
5x1fO-4llsA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_A_SAMA902_0
(MRNA CAPPING ENZYME
P5)		 3v1v 2-METHYLISOBORNEOL
SYNTHASE
(Streptomyces
coelicolor) 		5 / 12 LEU A 274
GLY A 338
PHE A 393
THR A 341
VAL A 344
 GST  A 511 (-4.6A)
None
None
None
None
 1.29A 5x6yA-3v1vA:
undetectable		 5x6yA-3v1vA:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDQ_B_CHDB304_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		5 / 11 MET A 149
GLY A 177
GLN A 175
ARG A  44
GLY A 184
 GST  A 302 ( 4.1A)
None
None
IPE  A 301 (-3.1A)
None
 1.45A 5xdqA-4llsA:
0.0
5xdqB-4llsA:
undetectable
5xdqT-4llsA:
undetectable		 5xdqA-4llsA:
20.31
5xdqB-4llsA:
22.93
5xdqT-4llsA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDX_B_CHDB302_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		5 / 11 MET A 149
GLY A 177
GLN A 175
ARG A  44
GLY A 184
 GST  A 302 ( 4.1A)
None
None
IPE  A 301 (-3.1A)
None
 1.43A 5xdxA-4llsA:
1.7
5xdxB-4llsA:
undetectable
5xdxT-4llsA:
undetectable		 5xdxA-4llsA:
20.31
5xdxB-4llsA:
22.93
5xdxT-4llsA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2T_B_8LXB501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4od5 4-HYDROXYBENZOATE
OCTAPRENYLTRANSFERAS
E
(Aeropyrum
pernix) 		4 / 8 HIS A 126
PHE A 174
HIS A   8
PHE A 258
 None
None
GST  A 301 ( 4.9A)
None
 0.95A 5y2tB-4od5A:
undetectable		 5y2tB-4od5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z84_B_CHDB301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		5 / 11 MET A 149
GLY A 177
GLN A 175
ARG A  44
GLY A 184
 GST  A 302 ( 4.1A)
None
None
IPE  A 301 (-3.1A)
None
 1.44A 5z84A-4llsA:
0.1
5z84B-4llsA:
undetectable
5z84T-4llsA:
undetectable		 5z84A-4llsA:
20.31
5z84B-4llsA:
22.93
5z84T-4llsA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z86_B_CHDB302_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		5 / 11 MET A 149
GLY A 177
GLN A 175
ARG A  44
GLY A 184
 GST  A 302 ( 4.1A)
None
None
IPE  A 301 (-3.1A)
None
 1.46A 5z86A-4llsA:
2.2
5z86B-4llsA:
undetectable
5z86T-4llsA:
undetectable		 5z86A-4llsA:
20.31
5z86B-4llsA:
22.93
5z86T-4llsA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCO_B_CHDB302_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		5 / 11 MET A 149
GLY A 177
GLN A 175
ARG A  44
GLY A 184
 GST  A 302 ( 4.1A)
None
None
IPE  A 301 (-3.1A)
None
 1.44A 5zcoA-4llsA:
2.0
5zcoB-4llsA:
undetectable
5zcoT-4llsA:
undetectable		 5zcoA-4llsA:
20.31
5zcoB-4llsA:
22.93
5zcoT-4llsA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCP_B_CHDB301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		5 / 11 MET A 149
GLY A 177
GLN A 175
ARG A  44
GLY A 184
 GST  A 302 ( 4.1A)
None
None
IPE  A 301 (-3.1A)
None
 1.46A 5zcpA-4llsA:
1.5
5zcpB-4llsA:
undetectable
5zcpT-4llsA:
undetectable		 5zcpA-4llsA:
20.31
5zcpB-4llsA:
22.93
5zcpT-4llsA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCQ_B_CHDB301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		5 / 11 MET A 149
GLY A 177
GLN A 175
ARG A  44
GLY A 184
 GST  A 302 ( 4.1A)
None
None
IPE  A 301 (-3.1A)
None
 1.45A 5zcqA-4llsA:
0.6
5zcqB-4llsA:
undetectable
5zcqT-4llsA:
undetectable		 5zcqA-4llsA:
20.31
5zcqB-4llsA:
22.93
5zcqT-4llsA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A7P_A_9SCA601_1
(SERUM ALBUMIN)		 5kd0 AROMATIC
PRENYLTRANSFERASE
(Aspergillus
terreus) 		4 / 5 ASN A 411
VAL A 416
LEU A  90
SER A 177
 GST  A 502 (-3.7A)
None
None
XBU  A 501 (-2.7A)
 1.24A 6a7pA-5kd0A:
undetectable		 6a7pA-5kd0A:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_A_ZOLA401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		4 / 7 ASP A  80
ARG A  91
GLN A 153
LYS A 178
 CA  A 304 ( 2.9A)
GST  A 302 (-2.9A)
GST  A 302 (-3.7A)
GST  A 302 (-3.4A)
 0.95A 6g31A-4llsA:
23.7		 6g31A-4llsA:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_A_ZOLA401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		5 / 7 ASP A  80
ASP A  86
ARG A  91
GLN A 153
GLN A 213
 CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
GST  A 302 (-3.7A)
IPE  A 301 ( 4.1A)
 0.83A 6g31A-4llsA:
23.7		 6g31A-4llsA:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_B_ZOLB401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		5 / 6 ASP A  80
ASP A  86
ARG A  91
GLN A 153
GLN A 213
 CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
GST  A 302 (-3.7A)
IPE  A 301 ( 4.1A)
 0.91A 6g31B-4llsA:
23.8		 6g31B-4llsA:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_C_ZOLC401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		5 / 5 ASP A  80
ASP A  86
ARG A  91
GLN A 153
LYS A 178
 CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
GST  A 302 (-3.7A)
GST  A 302 (-3.4A)
 1.23A 6g31C-4llsA:
24.0		 6g31C-4llsA:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_D_ZOLD401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		5 / 7 LEU A  77
ASP A  80
ASP A  86
ARG A  91
GLN A 153
 None
CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
GST  A 302 (-3.7A)
 0.52A 6g31D-4llsA:
23.1		 6g31D-4llsA:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_D_ZOLD401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		5 / 7 LEU A  77
ASP A  80
ASP A  86
ARG A  91
GLN A 213
 None
CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
IPE  A 301 ( 4.1A)
 0.76A 6g31D-4llsA:
23.1		 6g31D-4llsA:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_E_ZOLE401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		4 / 4 LEU A  77
ASP A  80
ASP A  86
ARG A  91
 None
CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
 0.40A 6g31E-4llsA:
18.3		 6g31E-4llsA:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_F_ZOLF401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		4 / 5 ASP A  80
ASP A  86
ARG A  91
GLN A 153
 CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
GST  A 302 (-3.7A)
 0.57A 6g31F-4llsA:
24.0		 6g31F-4llsA:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_F_ZOLF401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		4 / 5 ASP A  80
ASP A  86
ARG A  91
GLN A 213
 CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
IPE  A 301 ( 4.1A)
 0.88A 6g31F-4llsA:
24.0		 6g31F-4llsA:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_G_ZOLG401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		4 / 7 ASP A  80
ASP A  86
ARG A  91
GLN A 153
 CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
GST  A 302 (-3.7A)
 0.51A 6g31G-4llsA:
22.8		 6g31G-4llsA:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_G_ZOLG401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		4 / 7 ASP A  80
ASP A  86
ARG A  91
GLN A 213
 CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
IPE  A 301 ( 4.1A)
 0.84A 6g31G-4llsA:
22.8		 6g31G-4llsA:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_G_ZOLG401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		4 / 7 ASP A  80
ASP A  86
ARG A  91
LYS A 178
 CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
GST  A 302 (-3.4A)
 0.82A 6g31G-4llsA:
22.8		 6g31G-4llsA:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_J_ZOLJ401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		5 / 6 LEU A  77
ASP A  80
ASP A  86
ARG A  91
GLN A 153
 None
CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
GST  A 302 (-3.7A)
 0.68A 6g31J-4llsA:
23.8		 6g31J-4llsA:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_J_ZOLJ401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		5 / 6 LEU A  77
ASP A  80
ASP A  86
ARG A  91
GLN A 213
 None
CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
IPE  A 301 ( 4.1A)
 1.01A 6g31J-4llsA:
23.8		 6g31J-4llsA:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_K_ZOLK401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		4 / 4 ASP A  80
ASP A  86
ARG A  91
GLN A 153
 CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
GST  A 302 (-3.7A)
 0.60A 6g31K-4llsA:
22.2		 6g31K-4llsA:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_L_ZOLL401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		4 / 6 ASP A  80
ASP A  86
ARG A  91
GLN A 153
 CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
GST  A 302 (-3.7A)
 0.72A 6g31L-4llsA:
23.5		 6g31L-4llsA:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_L_ZOLL401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		4 / 6 ASP A  80
ASP A  86
ARG A  91
GLN A 213
 CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
IPE  A 301 ( 4.1A)
 1.10A 6g31L-4llsA:
23.5		 6g31L-4llsA:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMF_G_CHDG104_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		5 / 10 ARG A  44
GLY A 184
MET A 149
GLY A 148
THR A 172
 IPE  A 301 (-3.1A)
None
GST  A 302 ( 4.1A)
None
None
 1.49A 6nmfG-4llsA:
undetectable
6nmfN-4llsA:
0.7
6nmfO-4llsA:
undetectable		 6nmfG-4llsA:
14.29
6nmfN-4llsA:
20.31
6nmfO-4llsA:
22.93