SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'GSH'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
11GS_A_EAAA211_1
(GLUTATHIONE
S-TRANSFERASE)		 1lbk GLUTATHIONE
S-TRANSFERASE CLASS
PI CHIMAERA (CODA)
(Homo
sapiens) 		6 / 7 TYR A   7
PHE A   8
VAL A  10
ARG A  13
ILE A 104
TYR A 108
 None
GSH  A 504 (-4.7A)
None
GSH  A 504 (-3.7A)
None
None
 0.59A 11gsA-1lbkA:
36.1		 11gsA-1lbkA:
97.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
11GS_A_EAAA211_1
(GLUTATHIONE
S-TRANSFERASE)		 1tu7 GLUTATHIONE
S-TRANSFERASE 2
(Onchocerca
volvulus) 		4 / 7 TYR A   7
PHE A   8
TYR A 106
GLY A 204
 None
GSH  A1001 (-4.8A)
None
None
 0.40A 11gsA-1tu7A:
31.0		 11gsA-1tu7A:
42.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
11GS_A_EAAA211_1
(GLUTATHIONE
S-TRANSFERASE)		 2hnl GLUTATHIONE
S-TRANSFERASE 1
(Onchocerca
volvulus) 		4 / 7 TYR A  32
PHE A  33
ARG A  38
ILE A 127
 None
None
GSH  A 501 (-4.3A)
None
 0.61A 11gsA-2hnlA:
25.5		 11gsA-2hnlA:
28.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
11GS_A_EAAA211_1
(GLUTATHIONE
S-TRANSFERASE)		 5d73 GLUTATHIONE
S-TRANSFERASE
(Wuchereria
bancrofti) 		4 / 7 TYR A   7
PHE A   8
TYR A 106
GLY A 204
 None
GSH  A 301 (-4.9A)
None
None
 0.39A 11gsA-5d73A:
31.0		 11gsA-5d73A:
42.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
11GS_B_EAAB211_1
(GLUTATHIONE
S-TRANSFERASE)		 1lbk GLUTATHIONE
S-TRANSFERASE CLASS
PI CHIMAERA (CODA)
(Homo
sapiens) 		6 / 7 TYR A   7
PHE A   8
GLY A  12
ARG A  13
ILE A 104
TYR A 108
 None
GSH  A 504 (-4.7A)
None
GSH  A 504 (-3.7A)
None
None
 0.53A 11gsB-1lbkA:
36.1		 11gsB-1lbkA:
97.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
11GS_B_EAAB211_1
(GLUTATHIONE
S-TRANSFERASE)		 1pd2 HEMATOPOIETIC
PROSTAGLANDIN D
SYNTHASE
(Rattus
norvegicus) 		4 / 7 TYR 1   8
PHE 1   9
GLY 1  13
ARG 1  14
 GSH  1 301 (-4.8A)
None
None
GSH  1 301 (-3.4A)
 0.48A 11gsB-1pd21:
23.9		 11gsB-1pd21:
28.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
11GS_B_EAAB211_1
(GLUTATHIONE
S-TRANSFERASE)		 1tu7 GLUTATHIONE
S-TRANSFERASE 2
(Onchocerca
volvulus) 		5 / 7 TYR A   7
PHE A   8
GLY A  12
TYR A 106
GLY A 204
 None
GSH  A1001 (-4.8A)
None
None
None
 0.39A 11gsB-1tu7A:
30.9		 11gsB-1tu7A:
42.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
11GS_B_EAAB211_1
(GLUTATHIONE
S-TRANSFERASE)		 1u3i GLUTATHIONE
S-TRANSFERASE 28 KDA
(Schistosoma
mansoni) 		4 / 7 TYR A  10
PHE A  11
GLY A  15
ARG A  16
 None
None
None
GSH  A 301 (-4.2A)
 0.66A 11gsB-1u3iA:
23.6		 11gsB-1u3iA:
23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
11GS_B_EAAB211_1
(GLUTATHIONE
S-TRANSFERASE)		 2hnl GLUTATHIONE
S-TRANSFERASE 1
(Onchocerca
volvulus) 		5 / 7 TYR A  32
PHE A  33
GLY A  37
ARG A  38
ILE A 127
 None
None
None
GSH  A 501 (-4.3A)
None
 0.62A 11gsB-2hnlA:
25.5		 11gsB-2hnlA:
28.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
11GS_B_EAAB211_1
(GLUTATHIONE
S-TRANSFERASE)		 2wdu GLUTATHIONE
TRANSFERASE SIGMA
CLASS
(Fasciola
hepatica) 		4 / 7 TYR A  10
PHE A  11
GLY A  15
ARG A  16
 DMS  A1214 ( 4.3A)
GSH  A 301 (-4.4A)
DMS  A1214 (-3.0A)
GDS  A 300 ( 4.1A)
 0.80A 11gsB-2wduA:
24.4		 11gsB-2wduA:
29.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
11GS_B_EAAB211_1
(GLUTATHIONE
S-TRANSFERASE)		 4q5n GLUTHATIONE
S-TRANSFERASE BLO T
8 ISOFORM
(Blomia
tropicalis) 		4 / 7 TYR A   8
GLY A  13
ILE A 116
TYR A 120
 None
None
GSH  A 402 ( 4.5A)
GSH  A 402 (-3.9A)
 0.81A 11gsB-4q5nA:
25.7		 11gsB-4q5nA:
27.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
11GS_B_EAAB211_1
(GLUTATHIONE
S-TRANSFERASE)		 5d73 GLUTATHIONE
S-TRANSFERASE
(Wuchereria
bancrofti) 		5 / 7 TYR A   7
PHE A   8
GLY A  12
TYR A 106
GLY A 204
 None
GSH  A 301 (-4.9A)
None
None
None
 0.37A 11gsB-5d73A:
31.0		 11gsB-5d73A:
42.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
13GS_A_SASA211_1
(GLUTATHIONE
S-TRANSFERASE)		 1lbk GLUTATHIONE
S-TRANSFERASE CLASS
PI CHIMAERA (CODA)
(Homo
sapiens) 		9 / 10 TYR A   7
PHE A   8
PRO A   9
VAL A  10
ARG A  13
VAL A  35
ILE A 104
TYR A 108
PRO A 202
 None
GSH  A 504 (-4.7A)
None
None
GSH  A 504 (-3.7A)
None
None
None
None
 0.59A 13gsA-1lbkA:
35.8		 13gsA-1lbkA:
97.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
13GS_A_SASA211_1
(GLUTATHIONE
S-TRANSFERASE)		 1tu7 GLUTATHIONE
S-TRANSFERASE 2
(Onchocerca
volvulus) 		5 / 10 TYR A   7
PHE A   8
TYR A 106
PRO A 201
GLY A 204
 None
GSH  A1001 (-4.8A)
None
None
None
 0.45A 13gsA-1tu7A:
30.7		 13gsA-1tu7A:
42.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
13GS_A_SASA211_1
(GLUTATHIONE
S-TRANSFERASE)		 5d73 GLUTATHIONE
S-TRANSFERASE
(Wuchereria
bancrofti) 		6 / 10 TYR A   7
PHE A   8
PRO A   9
TYR A 106
PRO A 201
GLY A 204
 None
GSH  A 301 (-4.9A)
None
None
None
None
 0.41A 13gsA-5d73A:
31.0		 13gsA-5d73A:
42.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
13GS_B_SASB211_1
(GLUTATHIONE
S-TRANSFERASE)		 1lbk GLUTATHIONE
S-TRANSFERASE CLASS
PI CHIMAERA (CODA)
(Homo
sapiens) 		8 / 9 PHE A   8
PRO A   9
VAL A  10
ARG A  13
VAL A  35
ILE A 104
TYR A 108
PRO A 202
 GSH  A 504 (-4.7A)
None
None
GSH  A 504 (-3.7A)
None
None
None
None
 0.62A 13gsB-1lbkA:
36.0		 13gsB-1lbkA:
97.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
13GS_B_SASB211_1
(GLUTATHIONE
S-TRANSFERASE)		 5d73 GLUTATHIONE
S-TRANSFERASE
(Wuchereria
bancrofti) 		5 / 9 PHE A   8
PRO A   9
TYR A 106
PRO A 201
GLY A 204
 GSH  A 301 (-4.9A)
None
None
None
None
 0.41A 13gsB-5d73A:
31.2		 13gsB-5d73A:
42.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BDW_B_DVAB6_0
(GRAMICIDIN A)		 4q5n GLUTHATIONE
S-TRANSFERASE BLO T
8 ISOFORM
(Blomia
tropicalis) 		3 / 3 TRP A   9
ALA A  15
VAL A  11
 GSH  A 401 ( 4.9A)
None
None
 0.94A 1bdwA-4q5nA:
undetectable
1bdwB-4q5nA:
undetectable		 1bdwA-4q5nA:
8.47
1bdwB-4q5nA:
8.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DMA_B_NCAB700_0
(EXOTOXIN A)		 4ysl BETA-LACTAMASE
DOMAIN PROTEIN
(Pseudomonas
putida) 		4 / 6 HIS A 236
GLY A 178
ALA A 180
TYR A 177
 None
None
GSH  A 302 (-3.5A)
None
 0.89A 1dmaB-4yslA:
undetectable		 1dmaB-4yslA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DVX_B_DIFB125_2
(TRANSTHYRETIN)		 4nhw GLUTATHIONE
S-TRANSFERASE
(Sinorhizobium
meliloti) 		4 / 7 ALA A  65
LEU A  62
THR A  74
VAL A  72
 None
GSH  A 301 (-3.7A)
None
None
 1.00A 1dvxB-4nhwA:
undetectable		 1dvxB-4nhwA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DYI_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 4eq9 ABC TRANSPORTER
SUBSTRATE-BINDING
PROTEIN-AMINO ACID
TRANSPORT
(Streptococcus
pneumoniae) 		5 / 12 ASP A  94
LEU A  93
PHE A  90
THR A 108
LEU A 105
 None
None
None
None
GSH  A 301 (-4.7A)
 1.12A 1dyiA-4eq9A:
undetectable		 1dyiA-4eq9A:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DYI_B_FOLB161_0
(DIHYDROFOLATE
REDUCTASE)		 4eq9 ABC TRANSPORTER
SUBSTRATE-BINDING
PROTEIN-AMINO ACID
TRANSPORT
(Streptococcus
pneumoniae) 		5 / 12 ASP A  94
LEU A  93
PHE A  90
THR A 108
LEU A 105
 None
None
None
None
GSH  A 301 (-4.7A)
 1.09A 1dyiB-4eq9A:
undetectable		 1dyiB-4eq9A:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7A_B_PFLB4002_1
(SERUM ALBUMIN)		 5f07 PUTATIVE GLUTATHIONE
S-TRANSFERASE FAMILY
PROTEIN
(Populus
trichocarpa) 		4 / 6 LEU A  35
VAL A  54
VAL A  12
GLN A  15
 GSH  A 301 ( 4.1A)
GSH  A 301 (-3.8A)
GSH  A 301 (-4.3A)
None
 0.93A 1e7aB-5f07A:
undetectable		 1e7aB-5f07A:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FFY_A_MRCA1993_1
(ISOLEUCYL-TRNA
SYNTHETASE)		 1qh5 PROTEIN
(HYDROXYACYLGLUTATHI
ONE HYDROLASE)
(Homo
sapiens) 		5 / 12 PRO A  30
GLY A 133
ASP A 134
PHE A 137
VAL A 138
 None
None
ZN  A 262 ( 2.4A)
GSH  A 463 (-4.9A)
None
 1.03A 1ffyA-1qh5A:
undetectable		 1ffyA-1qh5A:
14.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1GSE_A_EAAA224_1
(GLUTATHIONE
TRANSFERASE)		 1vf1 GLUTATHIONE
S-TRANSFERASE 3
(Gallus
gallus) 		5 / 12 ARG A  13
GLY A  14
LYS A  15
LEU A 107
PRO A 110
 None
None
GSH  A2457 (-3.6A)
None
None
 1.20A 1gseA-1vf1A:
32.8		 1gseA-1vf1A:
64.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1GSE_A_EAAA224_1
(GLUTATHIONE
TRANSFERASE)		 1vf1 GLUTATHIONE
S-TRANSFERASE 3
(Gallus
gallus) 		5 / 12 TYR A   9
ARG A  13
GLY A  14
LYS A  15
LEU A 107
 None
None
None
GSH  A2457 (-3.6A)
None
 0.91A 1gseA-1vf1A:
32.8		 1gseA-1vf1A:
64.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1GSE_A_EAAA224_1
(GLUTATHIONE
TRANSFERASE)		 1vf1 GLUTATHIONE
S-TRANSFERASE 3
(Gallus
gallus) 		5 / 12 TYR A   9
PHE A  10
GLY A  14
LYS A  15
LEU A 107
 None
None
None
GSH  A2457 (-3.6A)
None
 1.25A 1gseA-1vf1A:
32.8		 1gseA-1vf1A:
64.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1GSE_B_EAAB224_1
(GLUTATHIONE
TRANSFERASE)		 1vf1 GLUTATHIONE
S-TRANSFERASE 3
(Gallus
gallus) 		5 / 12 TYR A   9
ARG A  13
GLY A  14
LYS A  15
LEU A 107
 None
None
None
GSH  A2457 (-3.6A)
None
 0.94A 1gseB-1vf1A:
32.8		 1gseB-1vf1A:
64.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSF_C_EAAC223_1
(GLUTATHIONE
TRANSFERASE A1-1)		 5b7c S-CRYSTALLIN OCTVUS4
(Octopus
vulgaris) 		4 / 8 TYR A   8
GLY A  13
ARG A  14
LEU A 100
 None
None
GSH  A 301 (-4.1A)
None
 0.75A 1gsfC-5b7cA:
21.4		 1gsfC-5b7cA:
25.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1GTB_A_PZQA901_0
(GLUTATHIONE
S-TRANSFERASE)		 3cru GLUTATHIONE
S-TRANSFERASE
CLASS-MU 26 KDA
ISOZYME
(Schistosoma
japonicum) 		3 / 3 GLN A  67
TYR A 104
ARG A 108
 GSH  A 215 (-3.2A)
None
None
 0.76A 1gtbA-3cruA:
36.2		 1gtbA-3cruA:
99.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1GTB_A_PZQA901_0
(GLUTATHIONE
S-TRANSFERASE)		 4wr4 GLUTATHIONE
S-TRANSFERASE
CLASS-MU 26 KDA
ISOZYME
(Schistosoma
japonicum) 		3 / 3 GLN A  66
TYR A 103
ARG A 107
 GSH  A 301 (-3.2A)
None
None
 0.40A 1gtbA-4wr4A:
34.1		 1gtbA-4wr4A:
87.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1GTI_A_CCSA47_0
(GLUTATHIONE
S-TRANSFERASE)		 1lbk GLUTATHIONE
S-TRANSFERASE CLASS
PI CHIMAERA (CODA)
(Homo
sapiens) 		6 / 7 TRP A  38
LEU A  43
LEU A  48
GLY A  50
LEU A  52
TYR A  63
 GSH  A 504 (-3.9A)
None
None
None
GSH  A 504 (-4.7A)
None
 0.66A 1gtiA-1lbkA:
33.4		 1gtiA-1lbkA:
82.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1GTI_A_CCSA47_0
(GLUTATHIONE
S-TRANSFERASE)		 1zl9 GLUTATHIONE
S-TRANSFERASE 5
(Caenorhabditis
elegans) 		4 / 7 TRP A  39
LEU A  42
GLY A  51
LEU A  53
 GSH  A 501 (-4.1A)
None
None
GSH  A 501 (-4.5A)
 0.71A 1gtiA-1zl9A:
22.7		 1gtiA-1zl9A:
30.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1GTI_A_CCSA47_0
(GLUTATHIONE
S-TRANSFERASE)		 4q5f GLUTATHIONE
S-TRANSFERASE 1
(Ascaris
suum) 		4 / 7 TRP A  39
LEU A  42
GLY A  49
LEU A  51
 GSH  A 301 (-4.0A)
None
None
GSH  A 301 (-4.8A)
 0.72A 1gtiA-4q5fA:
24.3		 1gtiA-4q5fA:
31.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1GTI_B_CCSB47_0
(GLUTATHIONE
S-TRANSFERASE)		 1lbk GLUTATHIONE
S-TRANSFERASE CLASS
PI CHIMAERA (CODA)
(Homo
sapiens) 		5 / 7 TRP A  38
LEU A  48
GLY A  50
LEU A  52
TYR A  63
 GSH  A 504 (-3.9A)
None
None
GSH  A 504 (-4.7A)
None
 0.27A 1gtiB-1lbkA:
33.4		 1gtiB-1lbkA:
82.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1GTI_C_CCSC47_0
(GLUTATHIONE
S-TRANSFERASE)		 1lbk GLUTATHIONE
S-TRANSFERASE CLASS
PI CHIMAERA (CODA)
(Homo
sapiens) 		5 / 6 TRP A  38
LEU A  48
GLY A  50
LYS A  54
TYR A  63
 GSH  A 504 (-3.9A)
None
None
None
None
 0.56A 1gtiC-1lbkA:
33.2		 1gtiC-1lbkA:
82.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1GTI_D_CCSD47_0
(GLUTATHIONE
S-TRANSFERASE)		 1lbk GLUTATHIONE
S-TRANSFERASE CLASS
PI CHIMAERA (CODA)
(Homo
sapiens) 		6 / 7 TRP A  38
LEU A  48
GLY A  50
LEU A  52
LYS A  54
TYR A  63
 GSH  A 504 (-3.9A)
None
None
GSH  A 504 (-4.7A)
None
None
 0.38A 1gtiD-1lbkA:
33.3		 1gtiD-1lbkA:
82.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_D_CCSD47_0
(GLUTATHIONE
S-TRANSFERASE)		 1u3i GLUTATHIONE
S-TRANSFERASE 28 KDA
(Schistosoma
mansoni) 		4 / 7 TRP A  41
THR A  47
GLY A  51
LEU A  53
 GSH  A 301 (-4.0A)
None
None
GSH  A 301 (-4.4A)
 0.56A 1gtiD-1u3iA:
22.8		 1gtiD-1u3iA:
28.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1GTI_E_CCSE47_0
(GLUTATHIONE
S-TRANSFERASE)		 1lbk GLUTATHIONE
S-TRANSFERASE CLASS
PI CHIMAERA (CODA)
(Homo
sapiens) 		6 / 7 TRP A  38
LEU A  48
GLY A  50
LEU A  52
LYS A  54
TYR A  63
 GSH  A 504 (-3.9A)
None
None
GSH  A 504 (-4.7A)
None
None
 0.35A 1gtiE-1lbkA:
33.1		 1gtiE-1lbkA:
82.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H7X_A_URFA1033_1
(DIHYDROPYRIMIDINE
DEHYDROGENASE)		 4hi7 GI20122
(Drosophila
mojavensis) 		4 / 6 ILE A  65
ASN A  64
ASN A  50
THR A  54
 None
None
None
GSH  A 301 (-4.2A)
 1.16A 1h7xA-4hi7A:
2.2		 1h7xA-4hi7A:
12.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H7X_B_URFB1033_1
(DIHYDROPYRIMIDINE
DEHYDROGENASE)		 4hi7 GI20122
(Drosophila
mojavensis) 		4 / 6 ILE A  65
ASN A  64
ASN A  50
THR A  54
 None
None
None
GSH  A 301 (-4.2A)
 1.17A 1h7xB-4hi7A:
2.7		 1h7xB-4hi7A:
12.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H7X_C_URFC1033_1
(DIHYDROPYRIMIDINE
DEHYDROGENASE)		 4hi7 GI20122
(Drosophila
mojavensis) 		4 / 6 ILE A  65
ASN A  64
ASN A  50
THR A  54
 None
None
None
GSH  A 301 (-4.2A)
 1.14A 1h7xC-4hi7A:
undetectable		 1h7xC-4hi7A:
12.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H7X_D_URFD1033_1
(DIHYDROPYRIMIDINE
DEHYDROGENASE)		 4hi7 GI20122
(Drosophila
mojavensis) 		4 / 6 ILE A  65
ASN A  64
ASN A  50
THR A  54
 None
None
None
GSH  A 301 (-4.2A)
 1.15A 1h7xD-4hi7A:
2.7		 1h7xD-4hi7A:
12.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IBG_H_OBNH1_2
(IGG2B-KAPPA 40-50
FAB (HEAVY CHAIN)
IGG2B-KAPPA 40-50
FAB (LIGHT CHAIN))		 4kh7 GLUTATHIONE
S-TRANSFERASE FAMILY
PROTEIN
(Salmonella
enterica) 		4 / 7 THR A  11
SER A  10
HIS A 110
LEU A 140
 GSH  A 301 ( 4.4A)
GSH  A 301 (-2.5A)
None
None
 1.15A 1ibgL-4kh7A:
undetectable		 1ibgL-4kh7A:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J96_B_TESB904_1
(3ALPHA-HYDROXYSTEROI
D DEHYDROGENASE TYPE
3)		 1lbk GLUTATHIONE
S-TRANSFERASE CLASS
PI CHIMAERA (CODA)
(Homo
sapiens) 		4 / 7 TYR A   7
ILE A 161
GLU A 205
LEU A 201
 None
None
GSH  A 504 (-3.3A)
None
 1.09A 1j96B-1lbkA:
undetectable		 1j96B-1lbkA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JU6_A_LYAA317_1
(THYMIDYLATE SYNTHASE)		 1qgj PEROXIDASE N
(Arabidopsis
thaliana) 		5 / 11 ILE A 145
ASN A 154
LEU A 245
TYR A 262
ALA A 160
 None
GSH  A1794 (-3.3A)
None
None
None
 1.32A 1ju6A-1qgjA:
undetectable		 1ju6A-1qgjA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JU6_C_LYAC315_1
(THYMIDYLATE SYNTHASE)		 1qgj PEROXIDASE N
(Arabidopsis
thaliana) 		5 / 10 ILE A 145
ASN A 154
LEU A 245
TYR A 262
ALA A 160
 None
GSH  A1794 (-3.3A)
None
None
None
 1.32A 1ju6C-1qgjA:
0.0		 1ju6C-1qgjA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JU6_D_LYAD315_1
(THYMIDYLATE SYNTHASE)		 1qgj PEROXIDASE N
(Arabidopsis
thaliana) 		5 / 11 ILE A 145
ASN A 154
LEU A 245
TYR A 262
ALA A 160
 None
GSH  A1794 (-3.3A)
None
None
None
 1.32A 1ju6D-1qgjA:
undetectable		 1ju6D-1qgjA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_D_SAMD3293_0
(GLYCINE
N-METHYLTRANSFERASE)		 1f2e GLUTATHIONE
S-TRANSFERASE
(Sphingomonas
paucimobilis) 		5 / 12 GLY A   8
ALA A  13
SER A  11
HIS A 106
LEU A 101
 None
None
None
GSH  A 210 (-4.4A)
None
 1.11A 1kiaD-1f2eA:
0.0		 1kiaD-1f2eA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_D_SAMD3293_0
(GLYCINE
N-METHYLTRANSFERASE)		 4gf0 GLUTATHIONE
S-TRANSFERASE
(Sulfitobacter
sp.
NAS-14.1) 		5 / 12 GLY A  10
ALA A  15
SER A  13
HIS A 106
LEU A 101
 None
None
None
GSH  A 302 (-4.3A)
None
 1.02A 1kiaD-4gf0A:
undetectable		 1kiaD-4gf0A:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LWE_A_NVPA999_1
(HIV-1 REVERSE
TRANSCRIPTASE)		 4mf6 GLUTATHIONE
S-TRANSFERASE DOMAIN
(Paraburkholderia
graminis) 		4 / 7 VAL A 203
TYR A 197
GLY A 200
TRP A 189
 None
BEZ  A 303 (-4.2A)
None
GSH  A 302 (-4.4A)
 1.00A 1lweA-4mf6A:
undetectable		 1lweA-4mf6A:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_I_SAMI199_0
(METHIONINE REPRESSOR)		 5f05 PHI CLASS
GLUTATHIONE
TRANSFERASE GSTF5
(Populus
trichocarpa) 		5 / 11 GLU A  67
PRO A  51
HIS A   7
ALA A  57
GLY A   8
 GSH  A 301 (-2.6A)
None
None
None
None
 1.03A 1mjqI-5f05A:
undetectable
1mjqJ-5f05A:
undetectable		 1mjqI-5f05A:
14.95
1mjqJ-5f05A:
14.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MRL_B_DOLB301_1
(STREPTOGRAMIN A
ACETYLTRANSFERASE)		 4ags THIOL-DEPENDENT
REDUCTASE 1
(Leishmania
infantum) 		5 / 12 ILE A 301
PRO A 281
LEU A 234
VAL A 391
TYR A 436
 None
GSH  A1449 (-4.4A)
None
None
None
 1.43A 1mrlB-4agsA:
undetectable
1mrlC-4agsA:
undetectable		 1mrlB-4agsA:
16.67
1mrlC-4agsA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MSK_A_SAMA1301_0
(COBALAMIN-DEPENDENT
METHIONINE SYNTHASE)		 3ein GLUTATHIONE
S-TRANSFERASE 1-1
(Drosophila
melanogaster) 		5 / 10 ASP A 101
ARG A  67
TYR A 114
PRO A 115
TYR A 113
 None
GSH  A 210 (-3.6A)
None
None
None
 1.42A 1mskA-3einA:
undetectable		 1mskA-3einA:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MSK_A_SAMA1301_0
(COBALAMIN-DEPENDENT
METHIONINE SYNTHASE)		 5zwp GLUTATHIONE
S-TRANSFERASE 1
(Musca
domestica) 		5 / 10 ASP A 100
ARG A  66
TYR A 113
PRO A 114
TYR A 112
 None
GSH  A 301 (-3.4A)
FMT  A 302 (-4.4A)
None
None
 1.44A 1mskA-5zwpA:
undetectable		 1mskA-5zwpA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MT1_B_AG2B7001_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN)		 4isd GLUTATHIONE
S-TRANSFERASE
(Burkholderia
glumae) 		4 / 6 GLU A  28
ARG A 110
ASP A 170
LEU A 173
 None
GSH  A 301 (-4.7A)
None
None
 1.00A 1mt1B-4isdA:
undetectable
1mt1C-4isdA:
undetectable		 1mt1B-4isdA:
18.02
1mt1C-4isdA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_E_THAE5_1
(LIVER
CARBOXYLESTERASE I)		 4glt GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN
(Methylobacillus
flagellatus) 		5 / 12 LEU A  33
VAL A  31
SER A   9
VAL A  15
LEU A   3
 GSH  A 301 (-4.9A)
None
GSH  A 301 (-2.7A)
None
None
 0.85A 1mx1E-4gltA:
undetectable		 1mx1E-4gltA:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXD_A_ACRA734_1
(ALPHA AMYLASE)		 4uss GLUTATHIONYL
HYDROQUINONE
REDUCTASE
(Populus
trichocarpa) 		4 / 6 HIS A 292
TYR A 293
GLY A 295
TRP A  77
 None
None
None
GSH  A 500 ( 4.1A)
 0.90A 1mxdA-4ussA:
undetectable		 1mxdA-4ussA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXG_A_ACRA444_1
(ALPHA AMYLASE)		 4uss GLUTATHIONYL
HYDROQUINONE
REDUCTASE
(Populus
trichocarpa) 		4 / 7 HIS A 292
TYR A 293
GLY A 295
TRP A  77
 None
None
None
GSH  A 500 ( 4.1A)
 0.91A 1mxgA-4ussA:
undetectable		 1mxgA-4ussA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_B_SAMB1293_0
(GLYCINE
N-METHYLTRANSFERASE)		 1f2e GLUTATHIONE
S-TRANSFERASE
(Sphingomonas
paucimobilis) 		5 / 12 GLY A   8
ALA A  13
SER A  11
HIS A 106
LEU A 101
 None
None
None
GSH  A 210 (-4.4A)
None
 1.07A 1nbhB-1f2eA:
undetectable		 1nbhB-1f2eA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_B_SAMB1293_0
(GLYCINE
N-METHYLTRANSFERASE)		 4gf0 GLUTATHIONE
S-TRANSFERASE
(Sulfitobacter
sp.
NAS-14.1) 		5 / 12 GLY A  10
ALA A  15
SER A  13
HIS A 106
LEU A 101
 None
None
None
GSH  A 302 (-4.3A)
None
 0.99A 1nbhB-4gf0A:
undetectable		 1nbhB-4gf0A:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NX9_A_AICA5001_1
(ALPHA-AMINO ACID
ESTER HYDROLASE)		 5an1 GLUTATHIONE
S-TRANSFERASE
(Litopenaeus
vannamei) 		4 / 8 TYR A 125
GLU A 109
SER A  73
TYR A   7
 None
None
GSH  A1220 (-2.7A)
None
 1.11A 1nx9A-5an1A:
undetectable		 1nx9A-5an1A:
14.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NX9_C_AICC5003_1
(ALPHA-AMINO ACID
ESTER HYDROLASE)		 5an1 GLUTATHIONE
S-TRANSFERASE
(Litopenaeus
vannamei) 		4 / 8 TYR A 125
GLU A 109
SER A  73
TYR A   7
 None
None
GSH  A1220 (-2.7A)
None
 1.12A 1nx9C-5an1A:
undetectable		 1nx9C-5an1A:
14.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NX9_D_AICD5004_1
(ALPHA-AMINO ACID
ESTER HYDROLASE)		 5an1 GLUTATHIONE
S-TRANSFERASE
(Litopenaeus
vannamei) 		4 / 8 TYR A 125
GLU A 109
SER A  73
TYR A   7
 None
None
GSH  A1220 (-2.7A)
None
 1.12A 1nx9D-5an1A:
undetectable		 1nx9D-5an1A:
14.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1O76_A_CAMA1420_0
(CYTOCHROME P450-CAM)		 4z9n AMINO ACID ABC
TRANSPORTER,
PERIPLASMIC AMINO
ACID-BINDING PROTEIN
(Brucella
ovis) 		5 / 10 PHE A 206
THR A  83
LEU A  22
THR A 136
ASP A 103
 None
GSH  A 401 (-4.1A)
GSH  A 401 ( 4.7A)
GSH  A 401 ( 4.8A)
None
 1.36A 1o76A-4z9nA:
undetectable		 1o76A-4z9nA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_B_BEZB503_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 1tu7 GLUTATHIONE
S-TRANSFERASE 2
(Onchocerca
volvulus) 		4 / 6 ARG A  18
ALA A  14
ILE A  66
PRO A  51
 None
None
None
GSH  A1001 (-4.3A)
 1.25A 1oniB-1tu7A:
undetectable
1oniC-1tu7A:
undetectable		 1oniB-1tu7A:
25.13
1oniC-1tu7A:
25.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_B_BEZB503_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 1v40 GLUTATHIONE-REQUIRIN
G PROSTAGLANDIN D
SYNTHASE
(Homo
sapiens) 		4 / 6 ARG A  19
ALA A  15
ILE A  53
PRO A  52
 None
None
None
GSH  A3200 ( 4.5A)
 1.26A 1oniB-1v40A:
undetectable
1oniC-1v40A:
undetectable		 1oniB-1v40A:
19.10
1oniC-1v40A:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_B_BEZB503_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 2hnl GLUTATHIONE
S-TRANSFERASE 1
(Onchocerca
volvulus) 		4 / 6 ARG A  43
ALA A  39
ILE A  91
PRO A  76
 None
None
None
GSH  A 501 (-4.4A)
 1.28A 1oniB-2hnlA:
undetectable
1oniC-2hnlA:
undetectable		 1oniB-2hnlA:
20.00
1oniC-2hnlA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_C_FUAC701_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5ft3 GLUTATHIONE
S-TRANSFERASE
EPSILON 2
(Aedes
aegypti) 		5 / 12 PHE A 108
PHE A 120
LEU A  36
VAL A  34
PHE A  46
 GSH  A1221 (-3.8A)
None
GSH  A1221 (-3.7A)
None
None
 1.17A 1q23C-5ft3A:
undetectable		 1q23C-5ft3A:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_H_FUAH709_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5f07 PUTATIVE GLUTATHIONE
S-TRANSFERASE FAMILY
PROTEIN
(Populus
trichocarpa) 		5 / 12 SER A  37
VAL A  54
VAL A  12
ALA A  11
HIS A  32
 None
GSH  A 301 (-3.8A)
GSH  A 301 (-4.3A)
GSH  A 301 ( 4.4A)
None
 1.24A 1q23H-5f07A:
undetectable
1q23I-5f07A:
undetectable		 1q23H-5f07A:
20.55
1q23I-5f07A:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_L_FUAL710_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5ft3 GLUTATHIONE
S-TRANSFERASE
EPSILON 2
(Aedes
aegypti) 		5 / 11 PHE A 108
PHE A 120
LEU A  36
VAL A  34
PHE A  46
 GSH  A1221 (-3.8A)
None
GSH  A1221 (-3.7A)
None
None
 1.16A 1q23L-5ft3A:
undetectable		 1q23L-5ft3A:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QU2_A_MRCA1993_1
(ISOLEUCYL-TRNA
SYNTHETASE)		 1qh5 PROTEIN
(HYDROXYACYLGLUTATHI
ONE HYDROLASE)
(Homo
sapiens) 		5 / 12 PRO A  30
GLY A 133
ASP A 134
PHE A 137
VAL A 138
 None
None
ZN  A 262 ( 2.4A)
GSH  A 463 (-4.9A)
None
 1.03A 1qu2A-1qh5A:
undetectable		 1qu2A-1qh5A:
14.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG2_A_SPMA999_1
(TYROSYL-DNA
PHOSPHODIESTERASE 1)		 2ime 2-HYDROXYCHROMENE-2-
CARBOXYLATE
ISOMERASE
(Pseudomonas
putida) 		4 / 5 ASN A 181
TRP A 179
VAL A 168
PRO A 169
 None
GSH  A 301 (-4.0A)
GSH  A 301 (-4.2A)
None
 1.31A 1rg2A-2imeA:
0.3		 1rg2A-2imeA:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RGU_A_SPMA999_1
(TYROSYL-DNA
PHOSPHODIESTERASE 1)		 2ime 2-HYDROXYCHROMENE-2-
CARBOXYLATE
ISOMERASE
(Pseudomonas
putida) 		4 / 5 ASN A 181
TRP A 179
VAL A 168
PRO A 169
 None
GSH  A 301 (-4.0A)
GSH  A 301 (-4.2A)
None
 1.32A 1rguA-2imeA:
0.8		 1rguA-2imeA:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RMT_D_ADND1504_1
(CLASS B ACID
PHOSPHATASE)		 1qh5 PROTEIN
(HYDROXYACYLGLUTATHI
ONE HYDROLASE)
(Homo
sapiens) 		4 / 8 TYR A  13
ASP A  58
THR A 176
TYR A 175
 None
ZN  A 262 (-2.7A)
None
GSH  A 463 (-4.5A)
 1.12A 1rmtD-1qh5A:
undetectable		 1rmtD-1qh5A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RUK_L_ACTL611_0
(IMMUNOGLOBULIN
IGG2A, HEAVY CHAIN
IMMUNOGLOBULIN
IGG2A, LIGHT CHAIN)		 4q5n GLUTHATIONE
S-TRANSFERASE BLO T
8 ISOFORM
(Blomia
tropicalis) 		4 / 6 LEU A 115
TRP A 178
LEU A 223
PHE A  14
 None
None
None
GSH  A 401 (-4.2A)
 1.49A 1rukH-4q5nA:
undetectable
1rukL-4q5nA:
undetectable		 1rukH-4q5nA:
20.16
1rukL-4q5nA:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S8F_B_BEZB1503_0
(RAS-RELATED PROTEIN
RAB-9A)		 2hqm GLUTATHIONE
REDUCTASE
(Saccharomyces
cerevisiae) 		4 / 6 VAL A 232
THR A 231
GLU A 238
LEU A 233
 None
None
GSH  A3001 (-3.8A)
None
 1.04A 1s8fB-2hqmA:
undetectable		 1s8fB-2hqmA:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T9W_A_NFNA6001_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 4ri6 PHI CLASS
GLUTATHIONE
TRANSFERASE GSTF1
(Populus
tremula
x
Populus
tremuloides) 		3 / 3 SER A 114
GLY A 115
ARG A  70
 None
None
GSH  A 500 ( 4.5A)
 0.49A 1t9wA-4ri6A:
undetectable		 1t9wA-4ri6A:
12.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TDR_A_MTXA170_1
(TELLUROMETHIONYL
DIHYDROFOLATE
REDUCTASE)		 4eq9 ABC TRANSPORTER
SUBSTRATE-BINDING
PROTEIN-AMINO ACID
TRANSPORT
(Streptococcus
pneumoniae) 		5 / 12 ASP A  94
LEU A  93
PHE A  90
THR A 108
LEU A 105
 None
None
None
None
GSH  A 301 (-4.7A)
 1.13A 1tdrA-4eq9A:
undetectable		 1tdrA-4eq9A:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VQ1_B_SAMB301_0
(N5-GLUTAMINE
METHYLTRANSFERASE,
HEMK)		 1typ TRYPANOTHIONE
REDUCTASE
(Crithidia
fasciculata) 		5 / 12 ILE A  10
GLY A  11
GLY A  13
SER A  14
ALA A  46
 FAD  A 493 (-4.7A)
FAD  A 493 (-3.3A)
FAD  A 493 (-3.2A)
GSH  A 495 ( 3.5A)
FAD  A 493 (-3.2A)
 0.82A 1vq1B-1typA:
2.8		 1vq1B-1typA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA3_B_STRB2001_1
(MINERALOCORTICOID
RECEPTOR)		 1f2e GLUTATHIONE
S-TRANSFERASE
(Sphingomonas
paucimobilis) 		5 / 12 LEU A  44
ASN A  47
ALA A  54
SER A   6
LEU A  32
 None
None
None
None
GSH  A 210 ( 3.9A)
 1.43A 1ya3B-1f2eA:
0.2		 1ya3B-1f2eA:
24.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YC2_D_NCAD510_0
(NAD-DEPENDENT
DEACETYLASE 2)		 2hgs PROTEIN (GLUTATHIONE
SYNTHETASE)
(Homo
sapiens) 		4 / 5 ALA A 150
ASN A 146
ILE A 145
ASP A 127
 GSH  A 503 (-4.8A)
MG  A 501 ( 2.7A)
None
SO4  A 505 ( 4.8A)
 1.18A 1yc2D-2hgsA:
undetectable		 1yc2D-2hgsA:
20.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1Z9H_A_IMNA379_1
(MEMBRANE-ASSOCIATED
PROSTAGLANDIN E
SYNTHASE-2)		 2pbj PROSTAGLANDIN E
SYNTHASE 2
(Macaca
fascicularis) 		12 / 12 TYR A 107
THR A 109
CYH A 110
PRO A 111
PRO A 134
VAL A 250
TYR A 251
SER A 260
TYR A 263
ILE A 264
VAL A 343
LEU A 347
 HEM  A 476 (-4.0A)
HEM  A 476 (-4.1A)
GSH  A 477 (-3.3A)
HEM  A 476 (-4.2A)
HEM  A 476 (-4.1A)
None
None
None
None
HEM  A 476 (-4.7A)
None
None
 0.31A 1z9hA-2pbjA:
44.7		 1z9hA-2pbjA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1Z9H_B_IMNB381_1
(MEMBRANE-ASSOCIATED
PROSTAGLANDIN E
SYNTHASE-2)		 2pbj PROSTAGLANDIN E
SYNTHASE 2
(Macaca
fascicularis) 		12 / 12 TYR A 107
THR A 109
CYH A 110
PRO A 111
PRO A 134
VAL A 250
TYR A 251
SER A 260
TYR A 263
ILE A 264
VAL A 343
LEU A 347
 HEM  A 476 (-4.0A)
HEM  A 476 (-4.1A)
GSH  A 477 (-3.3A)
HEM  A 476 (-4.2A)
HEM  A 476 (-4.1A)
None
None
None
None
HEM  A 476 (-4.7A)
None
None
 0.31A 1z9hB-2pbjA:
44.7		 1z9hB-2pbjA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1Z9H_C_IMNC379_1
(MEMBRANE-ASSOCIATED
PROSTAGLANDIN E
SYNTHASE-2)		 2pbj PROSTAGLANDIN E
SYNTHASE 2
(Macaca
fascicularis) 		12 / 12 TYR A 107
THR A 109
CYH A 110
PRO A 111
PRO A 134
VAL A 250
TYR A 251
SER A 260
TYR A 263
ILE A 264
VAL A 343
LEU A 347
 HEM  A 476 (-4.0A)
HEM  A 476 (-4.1A)
GSH  A 477 (-3.3A)
HEM  A 476 (-4.2A)
HEM  A 476 (-4.1A)
None
None
None
None
HEM  A 476 (-4.7A)
None
None
 0.31A 1z9hC-2pbjA:
44.6		 1z9hC-2pbjA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1Z9H_D_IMND476_1
(MEMBRANE-ASSOCIATED
PROSTAGLANDIN E
SYNTHASE-2)		 2pbj PROSTAGLANDIN E
SYNTHASE 2
(Macaca
fascicularis) 		12 / 12 THR A 109
CYH A 110
PRO A 111
PRO A 134
ILE A 246
VAL A 250
TYR A 251
SER A 260
TYR A 263
ILE A 264
VAL A 343
LEU A 347
 HEM  A 476 (-4.1A)
GSH  A 477 (-3.3A)
HEM  A 476 (-4.2A)
HEM  A 476 (-4.1A)
HEM  A 476 ( 3.8A)
None
None
None
None
HEM  A 476 (-4.7A)
None
None
 0.35A 1z9hD-2pbjA:
44.7		 1z9hD-2pbjA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1H_A_GBNA502_1
(BRANCHED CHAIN
AMINOTRANSFERASE)		 4z9n AMINO ACID ABC
TRANSPORTER,
PERIPLASMIC AMINO
ACID-BINDING PROTEIN
(Brucella
ovis) 		4 / 8 THR A 136
GLY A 133
ALA A  63
TYR A 174
 GSH  A 401 ( 4.8A)
EDO  A 403 (-4.3A)
GSH  A 401 (-3.6A)
None
 0.77A 2a1hA-4z9nA:
undetectable
2a1hB-4z9nA:
undetectable		 2a1hA-4z9nA:
23.68
2a1hB-4z9nA:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_A_SAMA301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 4iel GLUTATHIONE
S-TRANSFERASE,
N-TERMINAL DOMAIN
PROTEIN
(Burkholderia
ambifaria) 		3 / 3 LYS A  15
ASP A  94
ASN A  67
 GSH  A 301 ( 4.3A)
None
None
 1.07A 2bm9A-4ielA:
undetectable		 2bm9A-4ielA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_A_SAMA301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 4kdx GLUTATHIONE
S-TRANSFERASE DOMAIN
(Paraburkholderia
graminis) 		3 / 3 LYS A  15
ASP A  94
ASN A  67
 GSH  A 301 ( 4.4A)
None
None
 1.08A 2bm9A-4kdxA:
undetectable		 2bm9A-4kdxA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BNN_B_FCNB1199_1
(EPOXIDASE)		 2hgs PROTEIN (GLUTATHIONE
SYNTHETASE)
(Homo
sapiens) 		4 / 8 TYR A 265
LEU A 208
GLU A 214
ALA A 210
 None
None
GSH  A 503 (-2.4A)
None
 1.02A 2bnnA-2hgsA:
undetectable
2bnnB-2hgsA:
undetectable		 2bnnA-2hgsA:
18.39
2bnnB-2hgsA:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DQY_C_CHDC3_0
(LIVER
CARBOXYLESTERASE 1)		 4ikh GLUTATHIONE
S-TRANSFERASE
(Pseudomonas
protegens) 		4 / 6 TRP A 189
LEU A 119
LEU A  94
PRO A 188
 GSH  A 303 (-4.3A)
None
None
None
 1.21A 2dqyC-4ikhA:
undetectable		 2dqyC-4ikhA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIK_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 5d73 GLUTATHIONE
S-TRANSFERASE
(Wuchereria
bancrofti) 		4 / 7 LEU A 125
PHE A 128
ARG A  95
THR A  99
 None
None
GSH  A 301 (-3.8A)
None
 1.01A 2eikA-5d73A:
undetectable
2eikJ-5d73A:
undetectable		 2eikA-5d73A:
16.63
2eikJ-5d73A:
15.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJ3_C_GBNC1414_1
(BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE)		 2hgs PROTEIN (GLUTATHIONE
SYNTHETASE)
(Homo
sapiens) 		5 / 8 ARG A 267
GLY A 369
GLY A 460
ALA A 462
ALA A 463
 GSH  A 503 (-3.7A)
SO4  A 505 ( 3.3A)
GSH  A 503 (-3.6A)
GSH  A 503 (-3.5A)
None
 1.47A 2ej3C-2hgsA:
undetectable		 2ej3C-2hgsA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8D_A_BEZA1001_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 4kh7 GLUTATHIONE
S-TRANSFERASE FAMILY
PROTEIN
(Salmonella
enterica) 		4 / 6 VAL A  13
SER A  10
ARG A   7
LEU A  31
 None
GSH  A 301 (-2.5A)
GSH  A 301 (-3.2A)
None
 1.29A 2f8dA-4kh7A:
undetectable		 2f8dA-4kh7A:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GJ5_A_VD3A163_1
(BETA-LACTOGLOBULIN)		 3ibh SACCHAROMYCES
CEREVISIAE GTT2
(Saccharomyces
cerevisiae) 		5 / 12 ILE A  83
GLU A 121
ILE A  89
ILE A  93
ALA A  36
 None
GSH  A 234 (-4.4A)
None
None
None
 1.23A 2gj5A-3ibhA:
undetectable		 2gj5A-3ibhA:
21.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2GSS_A_EAAA0_1
(GLUTATHIONE
S-TRANSFERASE P1-1)		 1lbk GLUTATHIONE
S-TRANSFERASE CLASS
PI CHIMAERA (CODA)
(Homo
sapiens) 		7 / 8 TYR A   7
PHE A   8
VAL A  10
ARG A  13
TRP A  38
ILE A 104
TYR A 108
 None
GSH  A 504 (-4.7A)
None
GSH  A 504 (-3.7A)
GSH  A 504 (-3.9A)
None
None
 0.67A 2gssA-1lbkA:
36.3		 2gssA-1lbkA:
97.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GSS_A_EAAA0_1
(GLUTATHIONE
S-TRANSFERASE P1-1)		 1m0u GST2 GENE PRODUCT
(Drosophila
melanogaster) 		4 / 8 TYR A  54
PHE A  55
TRP A  85
TYR A 153
 GSH  A 500 (-4.7A)
GSH  A 500 (-4.8A)
GSH  A 500 (-3.6A)
None
 0.85A 2gssA-1m0uA:
23.1		 2gssA-1m0uA:
23.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GSS_A_EAAA0_1
(GLUTATHIONE
S-TRANSFERASE P1-1)		 1m0u GST2 GENE PRODUCT
(Drosophila
melanogaster) 		4 / 8 TYR A  54
PHE A  55
VAL A  57
TRP A  85
 GSH  A 500 (-4.7A)
GSH  A 500 (-4.8A)
None
GSH  A 500 (-3.6A)
 0.43A 2gssA-1m0uA:
23.1		 2gssA-1m0uA:
23.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GSS_A_EAAA0_1
(GLUTATHIONE
S-TRANSFERASE P1-1)		 1pd2 HEMATOPOIETIC
PROSTAGLANDIN D
SYNTHASE
(Rattus
norvegicus) 		4 / 8 TYR 1   8
PHE 1   9
ARG 1  14
TRP 1  39
 GSH  1 301 (-4.8A)
None
GSH  1 301 (-3.4A)
GSH  1 301 (-3.6A)
 0.64A 2gssA-1pd21:
24.0		 2gssA-1pd21:
28.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2GSS_A_EAAA0_1
(GLUTATHIONE
S-TRANSFERASE P1-1)		 1tu7 GLUTATHIONE
S-TRANSFERASE 2
(Onchocerca
volvulus) 		4 / 8 TYR A   7
PHE A   8
TYR A 106
GLY A 204
 None
GSH  A1001 (-4.8A)
None
None
 0.47A 2gssA-1tu7A:
30.9		 2gssA-1tu7A:
41.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GSS_A_EAAA0_1
(GLUTATHIONE
S-TRANSFERASE P1-1)		 1u3i GLUTATHIONE
S-TRANSFERASE 28 KDA
(Schistosoma
mansoni) 		4 / 8 TYR A  10
PHE A  11
ARG A  16
TRP A  41
 None
None
GSH  A 301 (-4.2A)
GSH  A 301 (-4.0A)
 0.90A 2gssA-1u3iA:
23.6		 2gssA-1u3iA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GSS_A_EAAA0_1
(GLUTATHIONE
S-TRANSFERASE P1-1)		 1v40 GLUTATHIONE-REQUIRIN
G PROSTAGLANDIN D
SYNTHASE
(Homo
sapiens) 		4 / 8 TYR A   8
PHE A   9
ARG A  14
TRP A  39
 None
O16  A3201 (-3.0A)
O16  A3201 ( 3.8A)
GSH  A3200 (-4.1A)
 0.68A 2gssA-1v40A:
24.5		 2gssA-1v40A:
27.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GSS_A_EAAA0_1
(GLUTATHIONE
S-TRANSFERASE P1-1)		 2hnl GLUTATHIONE
S-TRANSFERASE 1
(Onchocerca
volvulus) 		5 / 8 TYR A  32
PHE A  33
ARG A  38
TRP A  63
ILE A 127
 None
None
GSH  A 501 (-4.3A)
GSH  A 501 (-3.9A)
None
 0.69A 2gssA-2hnlA:
25.5		 2gssA-2hnlA:
27.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2GSS_A_EAAA0_1
(GLUTATHIONE
S-TRANSFERASE P1-1)		 3vpq GLUTATHIONE
S-TRANSFERASE SIGMA
(Bombyx
mori) 		4 / 8 TYR A   8
PHE A   9
VAL A  11
TRP A  39
 GSH  A 301 (-4.3A)
GSH  A 301 (-4.3A)
None
GSH  A 301 (-3.5A)
 0.40A 2gssA-3vpqA:
20.5		 2gssA-3vpqA:
31.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2GSS_A_EAAA0_1
(GLUTATHIONE
S-TRANSFERASE P1-1)		 5d73 GLUTATHIONE
S-TRANSFERASE
(Wuchereria
bancrofti) 		4 / 8 TYR A   7
PHE A   8
TYR A 106
GLY A 204
 None
GSH  A 301 (-4.9A)
None
None
 0.49A 2gssA-5d73A:
31.1		 2gssA-5d73A:
42.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2GSS_B_EAAB0_1
(GLUTATHIONE
S-TRANSFERASE P1-1)		 1lbk GLUTATHIONE
S-TRANSFERASE CLASS
PI CHIMAERA (CODA)
(Homo
sapiens) 		7 / 8 TYR A   7
PHE A   8
VAL A  10
ARG A  13
TRP A  38
ILE A 104
TYR A 108
 None
GSH  A 504 (-4.7A)
None
GSH  A 504 (-3.7A)
GSH  A 504 (-3.9A)
None
None
 0.67A 2gssB-1lbkA:
36.3		 2gssB-1lbkA:
97.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GSS_B_EAAB0_1
(GLUTATHIONE
S-TRANSFERASE P1-1)		 1m0u GST2 GENE PRODUCT
(Drosophila
melanogaster) 		4 / 8 TYR A  54
PHE A  55
TRP A  85
TYR A 153
 GSH  A 500 (-4.7A)
GSH  A 500 (-4.8A)
GSH  A 500 (-3.6A)
None
 0.85A 2gssB-1m0uA:
23.1		 2gssB-1m0uA:
23.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GSS_B_EAAB0_1
(GLUTATHIONE
S-TRANSFERASE P1-1)		 1m0u GST2 GENE PRODUCT
(Drosophila
melanogaster) 		4 / 8 TYR A  54
PHE A  55
VAL A  57
TRP A  85
 GSH  A 500 (-4.7A)
GSH  A 500 (-4.8A)
None
GSH  A 500 (-3.6A)
 0.43A 2gssB-1m0uA:
23.1		 2gssB-1m0uA:
23.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GSS_B_EAAB0_1
(GLUTATHIONE
S-TRANSFERASE P1-1)		 1pd2 HEMATOPOIETIC
PROSTAGLANDIN D
SYNTHASE
(Rattus
norvegicus) 		4 / 8 TYR 1   8
PHE 1   9
ARG 1  14
TRP 1  39
 GSH  1 301 (-4.8A)
None
GSH  1 301 (-3.4A)
GSH  1 301 (-3.6A)
 0.64A 2gssB-1pd21:
24.0		 2gssB-1pd21:
28.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2GSS_B_EAAB0_1
(GLUTATHIONE
S-TRANSFERASE P1-1)		 1tu7 GLUTATHIONE
S-TRANSFERASE 2
(Onchocerca
volvulus) 		4 / 8 TYR A   7
PHE A   8
TYR A 106
GLY A 204
 None
GSH  A1001 (-4.8A)
None
None
 0.47A 2gssB-1tu7A:
30.9		 2gssB-1tu7A:
41.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GSS_B_EAAB0_1
(GLUTATHIONE
S-TRANSFERASE P1-1)		 1u3i GLUTATHIONE
S-TRANSFERASE 28 KDA
(Schistosoma
mansoni) 		4 / 8 TYR A  10
PHE A  11
ARG A  16
TRP A  41
 None
None
GSH  A 301 (-4.2A)
GSH  A 301 (-4.0A)
 0.90A 2gssB-1u3iA:
23.6		 2gssB-1u3iA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GSS_B_EAAB0_1
(GLUTATHIONE
S-TRANSFERASE P1-1)		 1v40 GLUTATHIONE-REQUIRIN
G PROSTAGLANDIN D
SYNTHASE
(Homo
sapiens) 		4 / 8 TYR A   8
PHE A   9
ARG A  14
TRP A  39
 None
O16  A3201 (-3.0A)
O16  A3201 ( 3.8A)
GSH  A3200 (-4.1A)
 0.68A 2gssB-1v40A:
24.5		 2gssB-1v40A:
27.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GSS_B_EAAB0_1
(GLUTATHIONE
S-TRANSFERASE P1-1)		 2hnl GLUTATHIONE
S-TRANSFERASE 1
(Onchocerca
volvulus) 		5 / 8 TYR A  32
PHE A  33
ARG A  38
TRP A  63
ILE A 127
 None
None
GSH  A 501 (-4.3A)
GSH  A 501 (-3.9A)
None
 0.69A 2gssB-2hnlA:
25.4		 2gssB-2hnlA:
27.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2GSS_B_EAAB0_1
(GLUTATHIONE
S-TRANSFERASE P1-1)		 3vpq GLUTATHIONE
S-TRANSFERASE SIGMA
(Bombyx
mori) 		4 / 8 TYR A   8
PHE A   9
VAL A  11
TRP A  39
 GSH  A 301 (-4.3A)
GSH  A 301 (-4.3A)
None
GSH  A 301 (-3.5A)
 0.40A 2gssB-3vpqA:
20.5		 2gssB-3vpqA:
31.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2GSS_B_EAAB0_1
(GLUTATHIONE
S-TRANSFERASE P1-1)		 5d73 GLUTATHIONE
S-TRANSFERASE
(Wuchereria
bancrofti) 		4 / 8 TYR A   7
PHE A   8
TYR A 106
GLY A 204
 None
GSH  A 301 (-4.9A)
None
None
 0.48A 2gssB-5d73A:
31.0		 2gssB-5d73A:
42.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J9D_A_ACTA1117_0
(HYPOTHETICAL
NITROGEN REGULATORY
PII-LIKE PROTEIN
MJ0059)		 4kf9 GLUTATHIONE
S-TRANSFERASE
PROTEIN
(Ralstonia
solanacearum) 		3 / 3 ASP A 278
ARG A  54
ARG A  53
 None
GSH  A 405 (-3.9A)
GSH  A 405 (-3.5A)
 0.67A 2j9dA-4kf9A:
undetectable
2j9dC-4kf9A:
undetectable		 2j9dA-4kf9A:
13.73
2j9dC-4kf9A:
13.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKJ_D_CLMD1142_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 5h5l GLUTATHIONE
S-TRANSFERASE S2
(Nilaparvata
lugens) 		4 / 5 PRO A  17
ILE A 159
GLY A  13
TYR A   8
 None
None
PEG  A 302 (-3.5A)
GSH  A 301 ( 4.9A)
 1.12A 2jkjD-5h5lA:
undetectable		 2jkjD-5h5lA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKJ_F_CLMF1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 5h5l GLUTATHIONE
S-TRANSFERASE S2
(Nilaparvata
lugens) 		4 / 5 PRO A  17
ILE A 159
GLY A  13
TYR A   8
 None
None
PEG  A 302 (-3.5A)
GSH  A 301 ( 4.9A)
 1.12A 2jkjF-5h5lA:
undetectable		 2jkjF-5h5lA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NV4_B_SAMB202_0
(UPF0066 PROTEIN
AF_0241)		 4z9n AMINO ACID ABC
TRANSPORTER,
PERIPLASMIC AMINO
ACID-BINDING PROTEIN
(Brucella
ovis) 		5 / 12 GLN A 131
ALA A 162
ASP A 177
GLY A 183
LEU A 186
 GSH  A 401 (-3.1A)
None
GSH  A 401 (-3.0A)
None
None
 1.26A 2nv4B-4z9nA:
undetectable		 2nv4B-4z9nA:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OTF_A_2TNA201_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 3ein GLUTATHIONE
S-TRANSFERASE 1-1
(Drosophila
melanogaster) 		4 / 5 LEU A  31
ILE A  53
SER A  10
GLY A   9
 None
GSH  A 210 (-4.3A)
GSH  A 210 (-3.1A)
None
 0.94A 2otfA-3einA:
undetectable		 2otfA-3einA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OTF_A_2TNA201_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 4i97 DELTA CLASS 1
GLUTATHIONE
S-TRANSFERASE
(Scaptomyza
nigrita) 		4 / 5 LEU A  31
ILE A  53
SER A  10
GLY A   9
 None
GSH  A 301 (-4.2A)
GSH  A 301 ( 4.6A)
None
 1.00A 2otfA-4i97A:
undetectable		 2otfA-4i97A:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OTF_A_2TNA201_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 5zwp GLUTATHIONE
S-TRANSFERASE 1
(Musca
domestica) 		4 / 5 LEU A  30
ILE A  52
SER A   9
GLY A   8
 None
GSH  A 301 (-4.2A)
GSH  A 301 ( 4.5A)
None
 0.94A 2otfA-5zwpA:
undetectable		 2otfA-5zwpA:
15.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PNJ_B_CHDB502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5g5a GLUTATHIONE
S-TRANSFERASE U25
(Arabidopsis
thaliana) 		4 / 7 ILE A 175
PRO A 200
GLY A 159
MET A  14
 None
None
None
GSH  A1222 ( 4.5A)
 1.23A 2pnjB-5g5aA:
undetectable		 2pnjB-5g5aA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QO4_A_CHDA130_0
(LIVER-BASIC FATTY
ACID BINDING PROTEIN)		 4ysl BETA-LACTAMASE
DOMAIN PROTEIN
(Pseudomonas
putida) 		5 / 12 LEU A 192
ALA A 187
ASP A 254
PHE A 173
HIS A 212
 None
None
None
GSH  A 302 ( 4.9A)
GSH  A 302 ( 4.8A)
 1.40A 2qo4A-4yslA:
undetectable		 2qo4A-4yslA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UXP_A_CLMA1211_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TTGR)		 1jlv GLUTATHIONE
TRANSFERASE GST1-3
(Anopheles
cracens) 		5 / 8 ALA A  19
LEU A  26
LEU A  28
ILE A 195
ILE A  52
 None
None
None
None
GSH  A 701 (-4.6A)
 1.41A 2uxpA-1jlvA:
undetectable		 2uxpA-1jlvA:
21.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2VD0_B_D27B1200_0
(GLUTATHIONE-REQUIRIN
G PROSTAGLANDIN D
SYNTHASE)		 1pd2 HEMATOPOIETIC
PROSTAGLANDIN D
SYNTHASE
(Rattus
norvegicus) 		10 / 10 MET 1  11
GLY 1  13
ARG 1  14
MET 1  99
TRP 1 104
ALA 1 105
TYR 1 152
CYH 1 156
THR 1 159
LEU 1 199
 None
None
GSH  1 301 (-3.4A)
None
None
None
None
None
None
None
 0.52A 2vd0B-1pd21:
32.8		 2vd0B-1pd21:
81.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VUF_A_FUAA2002_1
(SERUM ALBUMIN)		 3lsz GLUTATHIONE
S-TRANSFERASE
(Rhodobacter
sphaeroides) 		4 / 9 PHE A 108
ALA A 109
VAL A 113
GLU A 114
 None
None
None
GSH  A 300 ( 4.7A)
 0.60A 2vufA-3lszA:
undetectable		 2vufA-3lszA:
16.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6R_C_CTCC1385_0
(TETX2 PROTEIN)		 5uuo GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN
(Novosphingobium
aromaticivorans) 		5 / 12 ASP B 252
ASN B  58
ARG B 261
GLY B  55
GLY B 221
 None
GSH  B 302 ( 2.9A)
None
EDO  B 306 ( 3.0A)
None
 1.47A 2y6rC-5uuoB:
undetectable		 2y6rC-5uuoB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6R_C_CTCC1385_0
(TETX2 PROTEIN)		 5uuo GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN
(Novosphingobium
aromaticivorans) 		5 / 12 ASP B 252
ASN B  58
ARG B 261
GLY B  59
GLY B 221
 None
GSH  B 302 ( 2.9A)
None
None
None
 1.16A 2y6rC-5uuoB:
undetectable		 2y6rC-5uuoB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YOE_C_FL7C1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 4eq9 ABC TRANSPORTER
SUBSTRATE-BINDING
PROTEIN-AMINO ACID
TRANSPORT
(Streptococcus
pneumoniae) 		4 / 8 ASN A 103
GLY A  46
ASN A  45
ILE A 184
 GSH  A 301 (-4.2A)
None
GSH  A 301 (-3.3A)
GSH  A 301 (-4.6A)
 0.83A 2yoeB-4eq9A:
undetectable
2yoeC-4eq9A:
undetectable		 2yoeB-4eq9A:
19.29
2yoeC-4eq9A:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZBP_A_SAMA300_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 4z9n AMINO ACID ABC
TRANSPORTER,
PERIPLASMIC AMINO
ACID-BINDING PROTEIN
(Brucella
ovis) 		5 / 12 GLY A 183
LEU A 188
ILE A 293
SER A 179
LEU A  22
 None
None
None
None
GSH  A 401 ( 4.7A)
 1.08A 2zbpA-4z9nA:
undetectable		 2zbpA-4z9nA:
24.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZE2_A_T27A556_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 3r2q UNCHARACTERIZED
GST-LIKE PROTEIN
YIBF
(Escherichia
coli) 		5 / 10 PRO A  64
ASN A 152
VAL A  90
PRO A  77
LEU A  18
 GSH  A 301 (-4.7A)
None
None
None
None
 1.25A 2ze2A-3r2qA:
0.8		 2ze2A-3r2qA:
17.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZUL_A_SAMA376_0
(PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE)		 1zl9 GLUTATHIONE
S-TRANSFERASE 5
(Caenorhabditis
elegans) 		5 / 12 PHE A   9
GLY A  13
GLY A  11
VAL A  17
PRO A  54
 GSH  A 501 (-4.7A)
None
None
None
GSH  A 501 (-4.5A)
 1.02A 2zulA-1zl9A:
undetectable		 2zulA-1zl9A:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZUL_A_SAMA376_0
(PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE)		 2hnl GLUTATHIONE
S-TRANSFERASE 1
(Onchocerca
volvulus) 		5 / 12 PHE A  33
GLY A  37
GLY A  35
VAL A  41
PRO A  76
 None
None
None
None
GSH  A 501 (-4.4A)
 1.11A 2zulA-2hnlA:
undetectable		 2zulA-2hnlA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZXW_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 5d73 GLUTATHIONE
S-TRANSFERASE
(Wuchereria
bancrofti) 		4 / 7 LEU A 125
PHE A 128
ARG A  95
THR A  99
 None
None
GSH  A 301 (-3.8A)
None
 1.04A 2zxwN-5d73A:
undetectable
2zxwW-5d73A:
undetectable		 2zxwN-5d73A:
16.63
2zxwW-5d73A:
15.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A35_B_RBFB191_1
(LUMAZINE PROTEIN)		 3g5s METHYLENETETRAHYDROF
OLATE--TRNA-(URACIL-
5-)-METHYLTRANSFERAS
E TRMFO
(Thermus
thermophilus) 		5 / 12 VAL A 226
CYH A 223
THR A 279
ASP A 158
GLN A 391
 None
GSH  A 445 (-2.5A)
None
None
MG  A 446 ( 2.7A)
 1.21A 3a35B-3g5sA:
undetectable		 3a35B-3g5sA:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABL_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1oyj GLUTATHIONE
S-TRANSFERASE
(Oryza
sativa) 		4 / 5 GLN A  19
PHE A  17
LEU A  73
PHE A 164
 None
GSH  A 799 (-4.0A)
None
None
 1.47A 3ablC-1oyjA:
2.5
3ablJ-1oyjA:
0.0		 3ablC-1oyjA:
19.29
3ablJ-1oyjA:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADS_A_IMNA1_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4qq7 PUTATIVE STRINGENT
STARVATION PROTEIN A
(Burkholderia
cenocepacia) 		5 / 10 GLU A 109
GLY A 167
ARG A 128
ILE A 127
MET A 178
 GSH  A 301 ( 4.6A)
None
None
None
None
 1.27A 3adsA-4qq7A:
undetectable		 3adsA-4qq7A:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG4_W_CHDW1059_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 5d73 GLUTATHIONE
S-TRANSFERASE
(Wuchereria
bancrofti) 		4 / 7 LEU A 125
PHE A 128
ARG A  95
THR A  99
 None
None
GSH  A 301 (-3.8A)
None
 1.00A 3ag4N-5d73A:
undetectable
3ag4W-5d73A:
undetectable		 3ag4N-5d73A:
16.63
3ag4W-5d73A:
15.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARU_A_PNXA608_1
(CHITINASE A)		 2fhe GLUTATHIONE
S-TRANSFERASE
(Fasciola
hepatica) 		4 / 6 TRP A   7
ASN A 203
ALA A 207
HIS A 206
 GSH  A 233 (-3.9A)
None
None
None
 1.24A 3aruA-2fheA:
undetectable		 3aruA-2fheA:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B6R_B_CRNB603_1
(CREATINE KINASE
B-TYPE)		 5ft3 GLUTATHIONE
S-TRANSFERASE
EPSILON 2
(Aedes
aegypti) 		4 / 6 THR A  54
VAL A  55
CYH A  15
SER A  12
 GSH  A1221 (-3.1A)
GSH  A1221 (-4.1A)
None
GSH  A1221 (-2.5A)
 1.20A 3b6rB-5ft3A:
undetectable		 3b6rB-5ft3A:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJM_A_BJMA1_1
(DIPEPTIDYL PEPTIDASE
4)		 5f06 GLUTATHIONE
S-TRANSFERASE FAMILY
PROTEIN
(Populus
trichocarpa) 		5 / 12 ARG A  68
GLU A 104
TYR A 176
VAL A 116
ASN A 109
 GSH  A 301 (-4.0A)
None
None
None
None
 1.36A 3bjmA-5f06A:
undetectable		 3bjmA-5f06A:
14.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_F_SVRF502_2
(PHOSPHOLIPASE A2)		 4gsn GLUTATHIONE
S-TRANSFERASE E2
(Anopheles
gambiae) 		4 / 5 ILE A 163
SER A 164
PHE A 108
PRO A  14
 None
None
GSH  A 301 (-4.6A)
GSH  A 301 (-4.3A)
 1.32A 3bjwC-4gsnA:
undetectable		 3bjwC-4gsnA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_F_SVRF502_2
(PHOSPHOLIPASE A2)		 4hi7 GI20122
(Drosophila
mojavensis) 		4 / 5 ILE A 165
SER A 166
PHE A 108
PRO A  14
 None
None
GSH  A 301 (-4.6A)
GSH  A 301 (-4.6A)
 1.34A 3bjwC-4hi7A:
undetectable		 3bjwC-4hi7A:
16.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOY_A_HISA1001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 4gci GLUTATHIONE
S-TRANSFERASE
(Yersinia
pestis) 		5 / 10 ILE A 201
GLY A   9
ALA A  10
TYR A   6
HIS A  16
 None
None
GSH  A 302 ( 3.9A)
None
None
 1.25A 3boyA-4gciA:
undetectable
3boyC-4gciA:
undetectable		 3boyA-4gciA:
21.13
3boyC-4gciA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOY_A_HISA2001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 4gci GLUTATHIONE
S-TRANSFERASE
(Yersinia
pestis) 		5 / 10 TYR A   6
HIS A  16
ILE A 201
GLY A   9
ALA A  10
 None
None
None
None
GSH  A 302 ( 3.9A)
 1.24A 3boyA-4gciA:
undetectable
3boyB-4gciA:
undetectable		 3boyA-4gciA:
21.13
3boyB-4gciA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOY_A_HISA3001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 4gci GLUTATHIONE
S-TRANSFERASE
(Yersinia
pestis) 		5 / 10 TYR A   6
HIS A  16
ILE A 201
GLY A   9
ALA A  10
 None
None
None
None
GSH  A 302 ( 3.9A)
 1.25A 3boyB-4gciA:
undetectable
3boyC-4gciA:
undetectable		 3boyB-4gciA:
21.13
3boyC-4gciA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BPX_A_SALA257_1
(TRANSCRIPTIONAL
REGULATOR)		 1jlv GLUTATHIONE
TRANSFERASE GST1-3
(Anopheles
cracens) 		4 / 8 SER A  65
ARG A  66
ALA A  10
THR A 165
 GSH  A 701 (-2.5A)
GSH  A 701 (-3.5A)
None
None
 0.95A 3bpxA-1jlvA:
undetectable
3bpxB-1jlvA:
2.0		 3bpxA-1jlvA:
20.93
3bpxB-1jlvA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BPX_A_SALA257_1
(TRANSCRIPTIONAL
REGULATOR)		 3wyw GLUTATHIONE
S-TRANSFERASE
(Nilaparvata
lugens) 		4 / 8 SER A  67
ARG A  68
ALA A  12
THR A 167
 GSH  A 301 (-2.6A)
GSH  A 301 (-3.7A)
None
None
 0.92A 3bpxA-3wywA:
undetectable
3bpxB-3wywA:
1.7		 3bpxA-3wywA:
20.19
3bpxB-3wywA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BPX_A_SALA257_1
(TRANSCRIPTIONAL
REGULATOR)		 5zwp GLUTATHIONE
S-TRANSFERASE 1
(Musca
domestica) 		4 / 8 SER A  65
ARG A  66
ALA A  10
THR A 165
 GSH  A 301 (-2.6A)
GSH  A 301 (-3.4A)
None
None
 0.93A 3bpxA-5zwpA:
undetectable
3bpxB-5zwpA:
undetectable		 3bpxA-5zwpA:
22.22
3bpxB-5zwpA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BPX_B_SALB258_1
(TRANSCRIPTIONAL
REGULATOR)		 2wyo GLUTATHIONE
SYNTHETASE
(Trypanosoma
brucei) 		5 / 11 ALA A 152
ARG A 119
ILE A 499
GLY A 526
SER A 201
 None
GSH  A1556 (-3.1A)
None
None
None
 1.33A 3bpxA-2wyoA:
undetectable
3bpxB-2wyoA:
undetectable		 3bpxA-2wyoA:
13.80
3bpxB-2wyoA:
13.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C0Z_B_SHHB301_1
(HISTONE DEACETYLASE
7A)		 4ysl BETA-LACTAMASE
DOMAIN PROTEIN
(Pseudomonas
putida) 		5 / 8 HIS A  74
HIS A  76
ASP A 170
HIS A 212
GLY A 169
 FE  A 301 (-3.4A)
None
FE  A 301 ( 3.1A)
GSH  A 302 ( 4.8A)
None
 1.43A 3c0zB-4yslA:
undetectable		 3c0zB-4yslA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C0Z_C_SHHC301_1
(HISTONE DEACETYLASE
7A)		 4ysl BETA-LACTAMASE
DOMAIN PROTEIN
(Pseudomonas
putida) 		4 / 6 ASP A 183
HIS A  74
HIS A 149
ASP A  78
 None
FE  A 301 (-3.4A)
FE  A 301 ( 3.5A)
GSH  A 302 ( 4.4A)
 0.85A 3c0zC-4yslA:
undetectable		 3c0zC-4yslA:
21.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CSJ_B_CBLB211_0
(GLUTATHIONE
S-TRANSFERASE P)		 1lbk GLUTATHIONE
S-TRANSFERASE CLASS
PI CHIMAERA (CODA)
(Homo
sapiens) 		8 / 9 TYR A   7
PHE A   8
PRO A   9
VAL A  10
GLY A  12
ARG A  13
ILE A 104
TYR A 108
 None
GSH  A 504 (-4.7A)
None
None
None
GSH  A 504 (-3.7A)
None
None
 0.57A 3csjB-1lbkA:
36.2		 3csjB-1lbkA:
97.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CSJ_B_CBLB211_0
(GLUTATHIONE
S-TRANSFERASE P)		 1tu7 GLUTATHIONE
S-TRANSFERASE 2
(Onchocerca
volvulus) 		5 / 9 TYR A   7
PHE A   8
GLY A  12
TYR A 106
GLY A 204
 None
GSH  A1001 (-4.8A)
None
None
None
 0.40A 3csjB-1tu7A:
30.7		 3csjB-1tu7A:
41.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CSJ_B_CBLB211_0
(GLUTATHIONE
S-TRANSFERASE P)		 2hnl GLUTATHIONE
S-TRANSFERASE 1
(Onchocerca
volvulus) 		5 / 9 TYR A  32
PHE A  33
GLY A  37
ARG A  38
ILE A 127
 None
None
None
GSH  A 501 (-4.3A)
None
 0.61A 3csjB-2hnlA:
25.5		 3csjB-2hnlA:
27.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CSJ_B_CBLB211_0
(GLUTATHIONE
S-TRANSFERASE P)		 5d73 GLUTATHIONE
S-TRANSFERASE
(Wuchereria
bancrofti) 		6 / 9 TYR A   7
PHE A   8
PRO A   9
GLY A  12
TYR A 106
GLY A 204
 None
GSH  A 301 (-4.9A)
None
None
None
None
 0.37A 3csjB-5d73A:
30.8		 3csjB-5d73A:
42.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D2T_B_1FLB500_1
(TRANSTHYRETIN)		 4nhw GLUTATHIONE
S-TRANSFERASE
(Sinorhizobium
meliloti) 		4 / 6 ALA A  65
LEU A  62
THR A  74
VAL A  72
 None
GSH  A 301 (-3.7A)
None
None
 0.99A 3d2tB-4nhwA:
undetectable		 3d2tB-4nhwA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D9L_A_ACTA501_0
(CTD-PEPTIDE
RNA-BINDING PROTEIN
16)		 4q5r GLUTATHIONE
S-TRANSFERASE
(Blattella
germanica) 		4 / 5 PRO A  18
ILE A  19
PRO A  53
TYR A   9
 None
None
GSH  A 301 (-4.3A)
None
 1.14A 3d9lA-4q5rA:
undetectable
3d9lY-4q5rA:
undetectable		 3d9lA-4q5rA:
22.33
3d9lY-4q5rA:
2.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D9L_A_ACTA501_0
(CTD-PEPTIDE
RNA-BINDING PROTEIN
16)		 5h5l GLUTATHIONE
S-TRANSFERASE S2
(Nilaparvata
lugens) 		4 / 5 PRO A  17
ILE A  18
PRO A  52
TYR A   8
 None
None
GSH  A 301 (-4.3A)
GSH  A 301 ( 4.9A)
 1.22A 3d9lA-5h5lA:
2.5
3d9lY-5h5lA:
undetectable		 3d9lA-5h5lA:
18.96
3d9lY-5h5lA:
8.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DAT_A_MTXA201_2
(DIHYDROFOLATE
REDUCTASE)		 1qh5 PROTEIN
(HYDROXYACYLGLUTATHI
ONE HYDROLASE)
(Homo
sapiens) 		4 / 4 MET A 152
LYS A 143
ASN A 222
THR A 107
 None
GSH  A 463 (-2.9A)
None
None
 1.27A 3datA-1qh5A:
0.0		 3datA-1qh5A:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DDY_A_RBFA187_1
(LUMAZINE PROTEIN)		 3g5s METHYLENETETRAHYDROF
OLATE--TRNA-(URACIL-
5-)-METHYLTRANSFERAS
E TRMFO
(Thermus
thermophilus) 		5 / 12 VAL A 226
CYH A 223
THR A 279
ASP A 158
GLN A 391
 None
GSH  A 445 (-2.5A)
None
None
MG  A 446 ( 2.7A)
 1.13A 3ddyA-3g5sA:
undetectable		 3ddyA-3g5sA:
17.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3DGQ_A_EAAA211_1
(GLUTATHIONE
S-TRANSFERASE P)		 1lbk GLUTATHIONE
S-TRANSFERASE CLASS
PI CHIMAERA (CODA)
(Homo
sapiens) 		5 / 5 TYR A   7
ARG A  13
ILE A 104
TYR A 108
THR A 109
 None
GSH  A 504 (-3.7A)
None
None
None
 0.58A 3dgqA-1lbkA:
36.0		 3dgqA-1lbkA:
97.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DMF_A_SAMA388_0
(PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE)		 1zl9 GLUTATHIONE
S-TRANSFERASE 5
(Caenorhabditis
elegans) 		5 / 12 PHE A   9
GLY A  13
GLY A  11
VAL A  17
PRO A  54
 GSH  A 501 (-4.7A)
None
None
None
GSH  A 501 (-4.5A)
 1.03A 3dmfA-1zl9A:
undetectable		 3dmfA-1zl9A:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DMH_A_SAMA384_0
(PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE)		 1zl9 GLUTATHIONE
S-TRANSFERASE 5
(Caenorhabditis
elegans) 		5 / 12 PHE A   9
GLY A  13
GLY A  11
VAL A  17
PRO A  54
 GSH  A 501 (-4.7A)
None
None
None
GSH  A 501 (-4.5A)
 1.04A 3dmhA-1zl9A:
undetectable		 3dmhA-1zl9A:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G0B_A_T22A800_1
(DIPEPTIDYL PEPTIDASE
4)		 5f06 GLUTATHIONE
S-TRANSFERASE FAMILY
PROTEIN
(Populus
trichocarpa) 		5 / 12 ARG A  68
GLU A 104
TYR A 176
VAL A 116
ASN A 109
 GSH  A 301 (-4.0A)
None
None
None
None
 1.43A 3g0bA-5f06A:
undetectable		 3g0bA-5f06A:
13.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G0B_B_T22B800_1
(DIPEPTIDYL PEPTIDASE
4)		 5f06 GLUTATHIONE
S-TRANSFERASE FAMILY
PROTEIN
(Populus
trichocarpa) 		5 / 12 ARG A  68
GLU A 104
TYR A 176
VAL A 116
ASN A 109
 GSH  A 301 (-4.0A)
None
None
None
None
 1.42A 3g0bB-5f06A:
undetectable		 3g0bB-5f06A:
13.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G0B_C_T22C800_1
(DIPEPTIDYL PEPTIDASE
4)		 5f06 GLUTATHIONE
S-TRANSFERASE FAMILY
PROTEIN
(Populus
trichocarpa) 		5 / 12 ARG A  68
GLU A 104
TYR A 176
VAL A 116
ASN A 109
 GSH  A 301 (-4.0A)
None
None
None
None
 1.45A 3g0bC-5f06A:
undetectable		 3g0bC-5f06A:
13.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G0B_D_T22D800_1
(DIPEPTIDYL PEPTIDASE
4)		 5f06 GLUTATHIONE
S-TRANSFERASE FAMILY
PROTEIN
(Populus
trichocarpa) 		5 / 12 ARG A  68
GLU A 104
TYR A 176
VAL A 116
ASN A 109
 GSH  A 301 (-4.0A)
None
None
None
None
 1.42A 3g0bD-5f06A:
undetectable		 3g0bD-5f06A:
13.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GSS_A_EAAA212_1
(GLUTATHIONE
S-TRANSFERASE P1-1)		 1lbk GLUTATHIONE
S-TRANSFERASE CLASS
PI CHIMAERA (CODA)
(Homo
sapiens) 		5 / 7 TYR A   7
PHE A   8
ILE A 104
TYR A 108
THR A 109
 None
GSH  A 504 (-4.7A)
None
None
None
 0.65A 3gssA-1lbkA:
36.3		 3gssA-1lbkA:
97.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GSS_A_EAAA212_1
(GLUTATHIONE
S-TRANSFERASE P1-1)		 1lbk GLUTATHIONE
S-TRANSFERASE CLASS
PI CHIMAERA (CODA)
(Homo
sapiens) 		4 / 7 TYR A   7
PHE A   8
VAL A  10
ILE A 104
 None
GSH  A 504 (-4.7A)
None
None
 0.50A 3gssA-1lbkA:
36.3		 3gssA-1lbkA:
97.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GSS_A_EAAA212_1
(GLUTATHIONE
S-TRANSFERASE P1-1)		 1tu7 GLUTATHIONE
S-TRANSFERASE 2
(Onchocerca
volvulus) 		4 / 7 TYR A   7
PHE A   8
TYR A 106
GLY A 204
 None
GSH  A1001 (-4.8A)
None
None
 0.39A 3gssA-1tu7A:
30.9		 3gssA-1tu7A:
41.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GSS_A_EAAA212_1
(GLUTATHIONE
S-TRANSFERASE P1-1)		 5d73 GLUTATHIONE
S-TRANSFERASE
(Wuchereria
bancrofti) 		4 / 7 TYR A   7
PHE A   8
TYR A 106
GLY A 204
 None
GSH  A 301 (-4.9A)
None
None
 0.42A 3gssA-5d73A:
30.9		 3gssA-5d73A:
42.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GSS_B_EAAB211_1
(GLUTATHIONE
S-TRANSFERASE P1-1)		 1lbk GLUTATHIONE
S-TRANSFERASE CLASS
PI CHIMAERA (CODA)
(Homo
sapiens) 		5 / 7 TYR A   7
PHE A   8
ILE A 104
TYR A 108
THR A 109
 None
GSH  A 504 (-4.7A)
None
None
None
 0.65A 3gssB-1lbkA:
36.3		 3gssB-1lbkA:
97.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GSS_B_EAAB211_1
(GLUTATHIONE
S-TRANSFERASE P1-1)		 1lbk GLUTATHIONE
S-TRANSFERASE CLASS
PI CHIMAERA (CODA)
(Homo
sapiens) 		4 / 7 TYR A   7
PHE A   8
VAL A  10
ILE A 104
 None
GSH  A 504 (-4.7A)
None
None
 0.50A 3gssB-1lbkA:
36.3		 3gssB-1lbkA:
97.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GSS_B_EAAB211_1
(GLUTATHIONE
S-TRANSFERASE P1-1)		 1tu7 GLUTATHIONE
S-TRANSFERASE 2
(Onchocerca
volvulus) 		4 / 7 TYR A   7
PHE A   8
TYR A 106
GLY A 204
 None
GSH  A1001 (-4.8A)
None
None
 0.40A 3gssB-1tu7A:
30.9		 3gssB-1tu7A:
41.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GSS_B_EAAB211_1
(GLUTATHIONE
S-TRANSFERASE P1-1)		 5d73 GLUTATHIONE
S-TRANSFERASE
(Wuchereria
bancrofti) 		4 / 7 TYR A   7
PHE A   8
TYR A 106
GLY A 204
 None
GSH  A 301 (-4.9A)
None
None
 0.42A 3gssB-5d73A:
30.9		 3gssB-5d73A:
42.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWX_A_EPAA1_2
(PROTEIN (PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
(PPAR-DELTA)))		 3ibh SACCHAROMYCES
CEREVISIAE GTT2
(Saccharomyces
cerevisiae) 		5 / 12 HIS A 133
LEU A 125
ILE A 197
ILE A 193
LEU A  53
 GSH  A 234 (-3.4A)
None
None
None
GSH  A 234 ( 4.6A)
 1.33A 3gwxA-3ibhA:
undetectable		 3gwxA-3ibhA:
23.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H52_C_486C4_2
(GLUCOCORTICOID
RECEPTOR)		 1jlv GLUTATHIONE
TRANSFERASE GST1-3
(Anopheles
cracens) 		3 / 3 MET A 101
CYH A  69
PRO A  11
 GSH  A 701 (-3.7A)
None
GSH  A 701 ( 4.7A)
 1.28A 3h52C-1jlvA:
0.0		 3h52C-1jlvA:
20.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3HJO_A_EAAA211_1
(GLUTATHIONE
S-TRANSFERASE P)		 1lbk GLUTATHIONE
S-TRANSFERASE CLASS
PI CHIMAERA (CODA)
(Homo
sapiens) 		6 / 8 TYR A   7
PHE A   8
VAL A  10
VAL A  35
TRP A  38
GLN A  39
 None
GSH  A 504 (-4.7A)
None
None
GSH  A 504 (-3.9A)
None
 0.20A 3hjoA-1lbkA:
36.1		 3hjoA-1lbkA:
96.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3HJO_A_EAAA211_1
(GLUTATHIONE
S-TRANSFERASE P)		 1lbk GLUTATHIONE
S-TRANSFERASE CLASS
PI CHIMAERA (CODA)
(Homo
sapiens) 		6 / 8 TYR A   7
PHE A   8
VAL A  10
VAL A  35
TRP A  38
ILE A 104
 None
GSH  A 504 (-4.7A)
None
None
GSH  A 504 (-3.9A)
None
 0.54A 3hjoA-1lbkA:
36.1		 3hjoA-1lbkA:
96.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJO_A_EAAA211_1
(GLUTATHIONE
S-TRANSFERASE P)		 1m0u GST2 GENE PRODUCT
(Drosophila
melanogaster) 		4 / 8 TYR A  54
PHE A  55
VAL A  57
TRP A  85
 GSH  A 500 (-4.7A)
GSH  A 500 (-4.8A)
None
GSH  A 500 (-3.6A)
 0.49A 3hjoA-1m0uA:
23.0		 3hjoA-1m0uA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJO_A_EAAA211_1
(GLUTATHIONE
S-TRANSFERASE P)		 2hnl GLUTATHIONE
S-TRANSFERASE 1
(Onchocerca
volvulus) 		4 / 8 TYR A  32
PHE A  33
TRP A  63
ILE A 127
 None
None
GSH  A 501 (-3.9A)
None
 0.52A 3hjoA-2hnlA:
25.5		 3hjoA-2hnlA:
27.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3HJO_A_EAAA211_1
(GLUTATHIONE
S-TRANSFERASE P)		 3vpq GLUTATHIONE
S-TRANSFERASE SIGMA
(Bombyx
mori) 		4 / 8 TYR A   8
PHE A   9
VAL A  11
TRP A  39
 GSH  A 301 (-4.3A)
GSH  A 301 (-4.3A)
None
GSH  A 301 (-3.5A)
 0.30A 3hjoA-3vpqA:
20.6		 3hjoA-3vpqA:
31.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3HJO_A_EAAA211_1
(GLUTATHIONE
S-TRANSFERASE P)		 5d73 GLUTATHIONE
S-TRANSFERASE
(Wuchereria
bancrofti) 		4 / 8 TYR A   7
PHE A   8
TRP A  38
GLY A 204
 None
GSH  A 301 (-4.9A)
GSH  A 301 (-4.0A)
None
 0.25A 3hjoA-5d73A:
30.6		 3hjoA-5d73A:
41.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3HJO_B_EAAB211_1
(GLUTATHIONE
S-TRANSFERASE P)		 1lbk GLUTATHIONE
S-TRANSFERASE CLASS
PI CHIMAERA (CODA)
(Homo
sapiens) 		4 / 8 PHE A   8
VAL A  10
VAL A  35
TRP A  38
 GSH  A 504 (-4.7A)
None
None
GSH  A 504 (-3.9A)
 0.12A 3hjoB-1lbkA:
36.1		 3hjoB-1lbkA:
96.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3HJO_B_EAAB211_1
(GLUTATHIONE
S-TRANSFERASE P)		 1lbk GLUTATHIONE
S-TRANSFERASE CLASS
PI CHIMAERA (CODA)
(Homo
sapiens) 		4 / 8 PHE A   8
VAL A  35
TRP A  38
ILE A 104
 GSH  A 504 (-4.7A)
None
GSH  A 504 (-3.9A)
None
 0.55A 3hjoB-1lbkA:
36.1		 3hjoB-1lbkA:
96.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3HJO_B_EAAB211_1
(GLUTATHIONE
S-TRANSFERASE P)		 5d73 GLUTATHIONE
S-TRANSFERASE
(Wuchereria
bancrofti) 		4 / 8 PHE A   8
TRP A  38
ASN A 203
GLY A 204
 GSH  A 301 (-4.9A)
GSH  A 301 (-4.0A)
None
None
 0.36A 3hjoB-5d73A:
30.6		 3hjoB-5d73A:
41.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HRD_E_NIOE5660_1
(NICOTINATE
DEHYDROGENASE LARGE
MOLYBDOPTERIN
SUBUNIT
NICOTINATE
DEHYDROGENASE MEDIUM
MOLYBDOPTERIN
SUBUNIT)		 3cru GLUTATHIONE
S-TRANSFERASE
CLASS-MU 26 KDA
ISOZYME
(Schistosoma
japonicum) 		3 / 3 GLU A  34
GLU A  37
TRP A   8
 None
None
GSH  A 215 (-4.2A)
 1.35A 3hrdA-3cruA:
undetectable
3hrdE-3cruA:
undetectable
3hrdF-3cruA:
undetectable		 3hrdA-3cruA:
17.06
3hrdE-3cruA:
17.06
3hrdF-3cruA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IJD_B_C2FB314_1
(UNCHARACTERIZED
PROTEIN)		 5an1 GLUTATHIONE
S-TRANSFERASE
(Litopenaeus
vannamei) 		3 / 3 THR A 113
LYS A  50
GLU A 109
 None
GSH  A1220 (-3.6A)
None
 1.00A 3ijdB-5an1A:
undetectable		 3ijdB-5an1A:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IW1_A_ASDA1223_1
(CYTOCHROME P450
CYP125)		 4uss GLUTATHIONYL
HYDROQUINONE
REDUCTASE
(Populus
trichocarpa) 		5 / 12 VAL A  73
PRO A  50
SER A  53
VAL A  45
VAL A 129
 None
None
None
None
GSH  A 500 (-3.8A)
 1.12A 3iw1A-4ussA:
undetectable		 3iw1A-4ussA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_B_ROCB201_4
(HIV-1 PROTEASE)		 1jlv GLUTATHIONE
TRANSFERASE GST1-3
(Anopheles
cracens) 		4 / 4 ARG A  66
ASP A  80
GLY A  77
THR A  18
 GSH  A 701 (-3.5A)
None
None
None
 1.34A 3k4vB-1jlvA:
undetectable		 3k4vB-1jlvA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K9F_F_LFXF0_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B)		 4ags THIOL-DEPENDENT
REDUCTASE 1
(Leishmania
infantum) 		4 / 5 SER A 294
ARG A 245
GLY A 335
GLU A 351
 GSH  A1449 (-2.5A)
None
None
None
 1.02A 3k9fA-4agsA:
undetectable
3k9fB-4agsA:
undetectable
3k9fC-4agsA:
undetectable		 3k9fA-4agsA:
22.45
3k9fB-4agsA:
22.45
3k9fC-4agsA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K9F_H_LFXH0_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B)		 4ags THIOL-DEPENDENT
REDUCTASE 1
(Leishmania
infantum) 		4 / 6 ARG A 245
SER A 294
GLY A 335
GLU A 351
 None
GSH  A1449 (-2.5A)
None
None
 1.01A 3k9fA-4agsA:
undetectable
3k9fB-4agsA:
undetectable
3k9fD-4agsA:
undetectable		 3k9fA-4agsA:
22.45
3k9fB-4agsA:
22.45
3k9fD-4agsA:
22.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3KM6_A_EAAA222_1
(GLUTATHIONE
S-TRANSFERASE P)		 1lbk GLUTATHIONE
S-TRANSFERASE CLASS
PI CHIMAERA (CODA)
(Homo
sapiens) 		8 / 10 TYR A   7
PHE A   8
VAL A  10
GLY A  12
VAL A  35
TRP A  38
GLN A  39
ILE A 104
 None
GSH  A 504 (-4.7A)
None
None
None
GSH  A 504 (-3.9A)
None
None
 0.53A 3km6A-1lbkA:
35.8		 3km6A-1lbkA:
96.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3KM6_A_EAAA222_1
(GLUTATHIONE
S-TRANSFERASE P)		 1tu7 GLUTATHIONE
S-TRANSFERASE 2
(Onchocerca
volvulus) 		5 / 10 TYR A   7
PHE A   8
GLY A  12
ASN A 203
GLY A 204
 None
GSH  A1001 (-4.8A)
None
None
None
 0.35A 3km6A-1tu7A:
30.6		 3km6A-1tu7A:
41.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KM6_A_EAAA222_1
(GLUTATHIONE
S-TRANSFERASE P)		 2hnl GLUTATHIONE
S-TRANSFERASE 1
(Onchocerca
volvulus) 		5 / 10 TYR A  32
PHE A  33
GLY A  37
TRP A  63
ILE A 127
 None
None
None
GSH  A 501 (-3.9A)
None
 0.69A 3km6A-2hnlA:
25.3		 3km6A-2hnlA:
27.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KM6_A_EAAA222_1
(GLUTATHIONE
S-TRANSFERASE P)		 4q5n GLUTHATIONE
S-TRANSFERASE BLO T
8 ISOFORM
(Blomia
tropicalis) 		5 / 10 TYR A   8
VAL A  11
GLY A  13
TRP A  50
ILE A 116
 None
None
None
GSH  A 401 (-4.0A)
GSH  A 402 ( 4.5A)
 0.98A 3km6A-4q5nA:
25.4		 3km6A-4q5nA:
26.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3KM6_A_EAAA222_1
(GLUTATHIONE
S-TRANSFERASE P)		 5d73 GLUTATHIONE
S-TRANSFERASE
(Wuchereria
bancrofti) 		6 / 10 TYR A   7
PHE A   8
GLY A  12
TRP A  38
ASN A 203
GLY A 204
 None
GSH  A 301 (-4.9A)
None
GSH  A 301 (-4.0A)
None
None
 0.39A 3km6A-5d73A:
30.7		 3km6A-5d73A:
41.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3KM6_B_EAAB222_1
(GLUTATHIONE
S-TRANSFERASE P)		 1lbk GLUTATHIONE
S-TRANSFERASE CLASS
PI CHIMAERA (CODA)
(Homo
sapiens) 		6 / 9 TYR A   7
PHE A   8
VAL A  10
VAL A  35
TRP A  38
GLN A  39
 None
GSH  A 504 (-4.7A)
None
None
GSH  A 504 (-3.9A)
None
 0.29A 3km6B-1lbkA:
36.0		 3km6B-1lbkA:
96.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3KM6_B_EAAB222_1
(GLUTATHIONE
S-TRANSFERASE P)		 5d73 GLUTATHIONE
S-TRANSFERASE
(Wuchereria
bancrofti) 		5 / 9 TYR A   7
PHE A   8
TRP A  38
ASN A 203
GLY A 204
 None
GSH  A 301 (-4.9A)
GSH  A 301 (-4.0A)
None
None
 0.40A 3km6B-5d73A:
30.5		 3km6B-5d73A:
41.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3KMO_A_EAAA214_1
(GLUTATHIONE
S-TRANSFERASE P)		 1lbk GLUTATHIONE
S-TRANSFERASE CLASS
PI CHIMAERA (CODA)
(Homo
sapiens) 		7 / 9 TYR A   7
PHE A   8
VAL A  10
GLY A  12
VAL A  35
TRP A  38
GLN A  39
 None
GSH  A 504 (-4.7A)
None
None
None
GSH  A 504 (-3.9A)
None
 0.29A 3kmoA-1lbkA:
35.5		 3kmoA-1lbkA:
96.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3KMO_A_EAAA214_1
(GLUTATHIONE
S-TRANSFERASE P)		 1tu7 GLUTATHIONE
S-TRANSFERASE 2
(Onchocerca
volvulus) 		5 / 9 TYR A   7
PHE A   8
GLY A  12
ASN A 203
GLY A 204
 None
GSH  A1001 (-4.8A)
None
None
None
 0.38A 3kmoA-1tu7A:
30.3		 3kmoA-1tu7A:
41.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3KMO_A_EAAA214_1
(GLUTATHIONE
S-TRANSFERASE P)		 5d73 GLUTATHIONE
S-TRANSFERASE
(Wuchereria
bancrofti) 		6 / 9 TYR A   7
PHE A   8
GLY A  12
TRP A  38
ASN A 203
GLY A 204
 None
GSH  A 301 (-4.9A)
None
GSH  A 301 (-4.0A)
None
None
 0.43A 3kmoA-5d73A:
30.5		 3kmoA-5d73A:
41.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3KMO_B_EAAB213_1
(GLUTATHIONE
S-TRANSFERASE P)		 1lbk GLUTATHIONE
S-TRANSFERASE CLASS
PI CHIMAERA (CODA)
(Homo
sapiens) 		5 / 7 TYR A   7
PHE A   8
VAL A  10
VAL A  35
TRP A  38
 None
GSH  A 504 (-4.7A)
None
None
GSH  A 504 (-3.9A)
 0.19A 3kmoB-1lbkA:
35.6		 3kmoB-1lbkA:
96.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KMO_B_EAAB213_1
(GLUTATHIONE
S-TRANSFERASE P)		 1m0u GST2 GENE PRODUCT
(Drosophila
melanogaster) 		4 / 7 TYR A  54
PHE A  55
VAL A  57
TRP A  85
 GSH  A 500 (-4.7A)
GSH  A 500 (-4.8A)
None
GSH  A 500 (-3.6A)
 0.49A 3kmoB-1m0uA:
22.8		 3kmoB-1m0uA:
25.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3KMO_B_EAAB213_1
(GLUTATHIONE
S-TRANSFERASE P)		 1tu7 GLUTATHIONE
S-TRANSFERASE 2
(Onchocerca
volvulus) 		4 / 7 TYR A   7
PHE A   8
ASN A 203
GLY A 204
 None
GSH  A1001 (-4.8A)
None
None
 0.38A 3kmoB-1tu7A:
30.4		 3kmoB-1tu7A:
41.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3KMO_B_EAAB213_1
(GLUTATHIONE
S-TRANSFERASE P)		 3vpq GLUTATHIONE
S-TRANSFERASE SIGMA
(Bombyx
mori) 		4 / 7 TYR A   8
PHE A   9
VAL A  11
TRP A  39
 GSH  A 301 (-4.3A)
GSH  A 301 (-4.3A)
None
GSH  A 301 (-3.5A)
 0.36A 3kmoB-3vpqA:
20.4		 3kmoB-3vpqA:
31.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3KMO_B_EAAB213_1
(GLUTATHIONE
S-TRANSFERASE P)		 5d73 GLUTATHIONE
S-TRANSFERASE
(Wuchereria
bancrofti) 		5 / 7 TYR A   7
PHE A   8
TRP A  38
ASN A 203
GLY A 204
 None
GSH  A 301 (-4.9A)
GSH  A 301 (-4.0A)
None
None
 0.46A 3kmoB-5d73A:
30.5		 3kmoB-5d73A:
41.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_Q_TFPQ201_1
(PROTEIN S100-A4)		 4z9n AMINO ACID ABC
TRANSPORTER,
PERIPLASMIC AMINO
ACID-BINDING PROTEIN
(Brucella
ovis) 		4 / 8 GLY A  24
PHE A  25
ILE A 159
PHE A 206
 None
None
GSH  A 401 (-3.6A)
None
 0.93A 3ko0O-4z9nA:
undetectable
3ko0Q-4z9nA:
undetectable		 3ko0O-4z9nA:
16.04
3ko0Q-4z9nA:
16.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LTW_A_HLZA300_1
(ARYLAMINE
N-ACETYLTRANSFERASE
NAT)		 4z9n AMINO ACID ABC
TRANSPORTER,
PERIPLASMIC AMINO
ACID-BINDING PROTEIN
(Brucella
ovis) 		4 / 6 PHE A 144
VAL A 130
THR A 136
PHE A 107
 None
None
GSH  A 401 ( 4.8A)
None
 1.28A 3ltwA-4z9nA:
undetectable		 3ltwA-4z9nA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8Y_A_DIFA701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 4pyr PUTATIVE
BRANCHED-CHAIN AMINO
ACID ABC TRANSPORTER
(Chromobacterium
violaceum) 		5 / 11 LEU A 186
SER A 185
GLY A 336
ALA A 339
LEU A 342
 GSH  A 401 (-4.0A)
GSH  A 401 (-3.5A)
None
None
None
 1.16A 3n8yA-4pyrA:
undetectable		 3n8yA-4pyrA:
19.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3N9J_A_EAAA210_1
(GLUTATHIONE
S-TRANSFERASE P)		 1lbk GLUTATHIONE
S-TRANSFERASE CLASS
PI CHIMAERA (CODA)
(Homo
sapiens) 		7 / 8 TYR A   7
PHE A   8
VAL A  10
ARG A  13
TRP A  38
ILE A 104
TYR A 108
 None
GSH  A 504 (-4.7A)
None
GSH  A 504 (-3.7A)
GSH  A 504 (-3.9A)
None
None
 0.70A 3n9jA-1lbkA:
36.1		 3n9jA-1lbkA:
97.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N9J_A_EAAA210_1
(GLUTATHIONE
S-TRANSFERASE P)		 1m0u GST2 GENE PRODUCT
(Drosophila
melanogaster) 		4 / 8 TYR A  54
PHE A  55
VAL A  57
TRP A  85
 GSH  A 500 (-4.7A)
GSH  A 500 (-4.8A)
None
GSH  A 500 (-3.6A)
 0.40A 3n9jA-1m0uA:
23.1		 3n9jA-1m0uA:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N9J_A_EAAA210_1
(GLUTATHIONE
S-TRANSFERASE P)		 1pd2 HEMATOPOIETIC
PROSTAGLANDIN D
SYNTHASE
(Rattus
norvegicus) 		4 / 8 TYR 1   8
PHE 1   9
ARG 1  14
TRP 1  39
 GSH  1 301 (-4.8A)
None
GSH  1 301 (-3.4A)
GSH  1 301 (-3.6A)
 0.65A 3n9jA-1pd21:
23.9		 3n9jA-1pd21:
28.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3N9J_A_EAAA210_1
(GLUTATHIONE
S-TRANSFERASE P)		 1tu7 GLUTATHIONE
S-TRANSFERASE 2
(Onchocerca
volvulus) 		4 / 8 TYR A   7
PHE A   8
TYR A 106
GLY A 204
 None
GSH  A1001 (-4.8A)
None
None
 0.49A 3n9jA-1tu7A:
30.7		 3n9jA-1tu7A:
42.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N9J_A_EAAA210_1
(GLUTATHIONE
S-TRANSFERASE P)		 1u3i GLUTATHIONE
S-TRANSFERASE 28 KDA
(Schistosoma
mansoni) 		4 / 8 TYR A  10
PHE A  11
ARG A  16
TRP A  41
 None
None
GSH  A 301 (-4.2A)
GSH  A 301 (-4.0A)
 0.92A 3n9jA-1u3iA:
23.5		 3n9jA-1u3iA:
23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N9J_A_EAAA210_1
(GLUTATHIONE
S-TRANSFERASE P)		 1v40 GLUTATHIONE-REQUIRIN
G PROSTAGLANDIN D
SYNTHASE
(Homo
sapiens) 		4 / 8 TYR A   8
PHE A   9
ARG A  14
TRP A  39
 None
O16  A3201 (-3.0A)
O16  A3201 ( 3.8A)
GSH  A3200 (-4.1A)
 0.70A 3n9jA-1v40A:
24.4		 3n9jA-1v40A:
27.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N9J_A_EAAA210_1
(GLUTATHIONE
S-TRANSFERASE P)		 2hnl GLUTATHIONE
S-TRANSFERASE 1
(Onchocerca
volvulus) 		5 / 8 TYR A  32
PHE A  33
ARG A  38
TRP A  63
ILE A 127
 None
None
GSH  A 501 (-4.3A)
GSH  A 501 (-3.9A)
None
 0.69A 3n9jA-2hnlA:
25.4		 3n9jA-2hnlA:
28.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3N9J_A_EAAA210_1
(GLUTATHIONE
S-TRANSFERASE P)		 3vpq GLUTATHIONE
S-TRANSFERASE SIGMA
(Bombyx
mori) 		4 / 8 TYR A   8
PHE A   9
VAL A  11
TRP A  39
 GSH  A 301 (-4.3A)
GSH  A 301 (-4.3A)
None
GSH  A 301 (-3.5A)
 0.42A 3n9jA-3vpqA:
20.5		 3n9jA-3vpqA:
31.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3N9J_A_EAAA210_1
(GLUTATHIONE
S-TRANSFERASE P)		 5d73 GLUTATHIONE
S-TRANSFERASE
(Wuchereria
bancrofti) 		4 / 8 TYR A   7
PHE A   8
TYR A 106
GLY A 204
 None
GSH  A 301 (-4.9A)
None
None
 0.52A 3n9jA-5d73A:
30.9		 3n9jA-5d73A:
42.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3N9J_B_EAAB214_1
(GLUTATHIONE
S-TRANSFERASE P)		 1lbk GLUTATHIONE
S-TRANSFERASE CLASS
PI CHIMAERA (CODA)
(Homo
sapiens) 		5 / 8 TYR A   7
GLY A  12
ARG A  13
ILE A 104
TYR A 108
 None
None
GSH  A 504 (-3.7A)
None
None
 0.63A 3n9jB-1lbkA:
36.0		 3n9jB-1lbkA:
97.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3N9J_B_EAAB214_1
(GLUTATHIONE
S-TRANSFERASE P)		 1lbk GLUTATHIONE
S-TRANSFERASE CLASS
PI CHIMAERA (CODA)
(Homo
sapiens) 		6 / 8 TYR A   7
PHE A   8
VAL A  10
GLY A  12
ARG A  13
ILE A 104
 None
GSH  A 504 (-4.7A)
None
None
GSH  A 504 (-3.7A)
None
 0.51A 3n9jB-1lbkA:
36.0		 3n9jB-1lbkA:
97.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N9J_B_EAAB214_1
(GLUTATHIONE
S-TRANSFERASE P)		 1pd2 HEMATOPOIETIC
PROSTAGLANDIN D
SYNTHASE
(Rattus
norvegicus) 		4 / 8 TYR 1   8
PHE 1   9
GLY 1  13
ARG 1  14
 GSH  1 301 (-4.8A)
None
None
GSH  1 301 (-3.4A)
 0.53A 3n9jB-1pd21:
23.9		 3n9jB-1pd21:
28.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3N9J_B_EAAB214_1
(GLUTATHIONE
S-TRANSFERASE P)		 1tu7 GLUTATHIONE
S-TRANSFERASE 2
(Onchocerca
volvulus) 		5 / 8 TYR A   7
PHE A   8
GLY A  12
TYR A 106
GLY A 204
 None
GSH  A1001 (-4.8A)
None
None
None
 0.50A 3n9jB-1tu7A:
30.5		 3n9jB-1tu7A:
42.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N9J_B_EAAB214_1
(GLUTATHIONE
S-TRANSFERASE P)		 1u3i GLUTATHIONE
S-TRANSFERASE 28 KDA
(Schistosoma
mansoni) 		4 / 8 TYR A  10
PHE A  11
GLY A  15
ARG A  16
 None
None
None
GSH  A 301 (-4.2A)
 0.75A 3n9jB-1u3iA:
23.5		 3n9jB-1u3iA:
23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N9J_B_EAAB214_1
(GLUTATHIONE
S-TRANSFERASE P)		 2hnl GLUTATHIONE
S-TRANSFERASE 1
(Onchocerca
volvulus) 		5 / 8 TYR A  32
PHE A  33
GLY A  37
ARG A  38
ILE A 127
 None
None
None
GSH  A 501 (-4.3A)
None
 0.59A 3n9jB-2hnlA:
25.3		 3n9jB-2hnlA:
28.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N9J_B_EAAB214_1
(GLUTATHIONE
S-TRANSFERASE P)		 4q5n GLUTHATIONE
S-TRANSFERASE BLO T
8 ISOFORM
(Blomia
tropicalis) 		4 / 8 TYR A   8
VAL A  11
GLY A  13
ILE A 116
 None
None
None
GSH  A 402 ( 4.5A)
 0.67A 3n9jB-4q5nA:
25.6		 3n9jB-4q5nA:
27.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3N9J_B_EAAB214_1
(GLUTATHIONE
S-TRANSFERASE P)		 5d73 GLUTATHIONE
S-TRANSFERASE
(Wuchereria
bancrofti) 		5 / 8 TYR A   7
PHE A   8
GLY A  12
TYR A 106
GLY A 204
 None
GSH  A 301 (-4.9A)
None
None
None
 0.52A 3n9jB-5d73A:
30.7		 3n9jB-5d73A:
42.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NUV_A_ASDA126_1
(STEROID
DELTA-ISOMERASE)		 2jl4 MALEYLPYRUVATE
ISOMERASE
(Ralstonia
sp.
U2) 		5 / 12 SER A   9
LEU A  33
PHE A  43
ASN A  47
ALA A  54
 GSH  A1213 (-3.0A)
GSH  A1213 ( 4.4A)
None
None
None
 1.38A 3nuvA-2jl4A:
undetectable		 3nuvA-2jl4A:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OKX_A_SAMA201_1
(YAEB-LIKE PROTEIN
RPA0152)		 4ysl BETA-LACTAMASE
DOMAIN PROTEIN
(Pseudomonas
putida) 		4 / 5 HIS A 212
SER A  21
ASP A  40
THR A  17
 GSH  A 302 ( 4.8A)
None
None
None
 1.20A 3okxA-4yslA:
undetectable		 3okxA-4yslA:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OKX_B_SAMB201_2
(YAEB-LIKE PROTEIN
RPA0152)		 4ysl BETA-LACTAMASE
DOMAIN PROTEIN
(Pseudomonas
putida) 		4 / 5 HIS A 212
SER A  21
ASP A  40
THR A  17
 GSH  A 302 ( 4.8A)
None
None
None
 1.21A 3okxB-4yslA:
undetectable		 3okxB-4yslA:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_D_SAMD6735_0
(16S RRNA METHYLASE)		 4glt GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN
(Methylobacillus
flagellatus) 		6 / 12 GLY A 160
PRO A  10
ALA A 104
LEU A 182
LEU A 166
TYR A 170
 None
GSH  A 301 (-4.4A)
None
None
None
None
 1.30A 3p2kD-4gltA:
undetectable		 3p2kD-4gltA:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P5N_A_RBFA190_1
(RIBOFLAVIN UPTAKE
PROTEIN)		 2jac GLUTAREDOXIN-1
(Saccharomyces
cerevisiae) 		5 / 12 ASP A  89
GLY A  87
ALA A  22
LEU A  66
ASN A  70
 GSH  A1000 (-3.2A)
GSH  A1000 (-3.5A)
None
None
None
 1.05A 3p5nA-2jacA:
undetectable		 3p5nA-2jacA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P5N_B_RBFB190_1
(RIBOFLAVIN UPTAKE
PROTEIN)		 2jac GLUTAREDOXIN-1
(Saccharomyces
cerevisiae) 		5 / 12 ASP A  89
GLY A  87
ALA A  22
LEU A  66
ASN A  70
 GSH  A1000 (-3.2A)
GSH  A1000 (-3.5A)
None
None
None
 1.04A 3p5nB-2jacA:
undetectable		 3p5nB-2jacA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PS9_A_SAMA670_1
(TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC)		 4pqi IN2-1 FAMILY
PROTEIN, GLUTATHIONE
TRANSFERASE LAMBDA3
(Populus
trichocarpa) 		5 / 6 TYR A  79
GLY A  95
THR A  94
LEU A  87
GLU A  96
 None
None
None
None
GSH  A 301 (-3.2A)
 1.48A 3ps9A-4pqiA:
undetectable		 3ps9A-4pqiA:
15.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q1E_D_T44D328_1
(5-HYDROXYISOURATE
HYDROLASE)		 1oyj GLUTATHIONE
S-TRANSFERASE
(Oryza
sativa) 		5 / 9 LEU A   9
PRO A  57
LEU A  59
HIS A 210
LEU A  73
 None
GSH  A 799 (-4.2A)
None
None
None
 1.42A 3q1eB-1oyjA:
0.0
3q1eD-1oyjA:
0.0		 3q1eB-1oyjA:
18.45
3q1eD-1oyjA:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q1E_D_T44D328_1
(5-HYDROXYISOURATE
HYDROLASE)		 4gf0 GLUTATHIONE
S-TRANSFERASE
(Sulfitobacter
sp.
NAS-14.1) 		5 / 9 LEU A   5
PRO A  54
LEU A  56
THR A  67
LEU A  71
 None
GSH  A 302 (-4.4A)
None
GSH  A 302 (-4.0A)
None
 1.24A 3q1eB-4gf0A:
undetectable
3q1eD-4gf0A:
undetectable		 3q1eB-4gf0A:
20.40
3q1eD-4gf0A:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q1E_D_T44D328_1
(5-HYDROXYISOURATE
HYDROLASE)		 4gsn GLUTATHIONE
S-TRANSFERASE E2
(Anopheles
gambiae) 		5 / 9 LEU A   9
PRO A  13
LEU A  11
HIS A  41
LEU A 119
 None
GSH  A 301 ( 4.9A)
None
GSH  A 301 (-4.2A)
None
 1.45A 3q1eB-4gsnA:
undetectable
3q1eD-4gsnA:
undetectable		 3q1eB-4gsnA:
25.00
3q1eD-4gsnA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q1E_D_T44D328_1
(5-HYDROXYISOURATE
HYDROLASE)		 4kf9 GLUTATHIONE
S-TRANSFERASE
PROTEIN
(Ralstonia
solanacearum) 		5 / 9 HIS A  10
LEU A   8
PRO A  56
LEU A  58
THR A  68
 None
None
None
None
GSH  A 405 (-3.0A)
 1.05A 3q1eB-4kf9A:
undetectable
3q1eD-4kf9A:
undetectable		 3q1eB-4kf9A:
15.48
3q1eD-4kf9A:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q1E_D_T44D328_1
(5-HYDROXYISOURATE
HYDROLASE)		 4kf9 GLUTATHIONE
S-TRANSFERASE
PROTEIN
(Ralstonia
solanacearum) 		5 / 9 HIS A  10
LEU A   8
PRO A  56
THR A  68
HIS A 224
 None
None
None
GSH  A 405 (-3.0A)
ZN  A 401 ( 3.2A)
 0.91A 3q1eB-4kf9A:
undetectable
3q1eD-4kf9A:
undetectable		 3q1eB-4kf9A:
15.48
3q1eD-4kf9A:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QLH_A_T27A555_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 1m0u GST2 GENE PRODUCT
(Drosophila
melanogaster) 		5 / 12 PRO A  98
LEU A  52
TYR A  54
PRO A 245
TYR A  75
 GSH  A 500 ( 4.5A)
None
GSH  A 500 (-4.7A)
None
None
 1.35A 3qlhA-1m0uA:
0.0		 3qlhA-1m0uA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QLH_A_T27A555_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 1pd2 HEMATOPOIETIC
PROSTAGLANDIN D
SYNTHASE
(Rattus
norvegicus) 		5 / 12 PRO 1  52
LEU 1   6
TYR 1   8
PRO 1 195
TYR 1  29
 GSH  1 301 ( 4.5A)
None
GSH  1 301 (-4.8A)
None
None
 1.40A 3qlhA-1pd21:
0.9		 3qlhA-1pd21:
17.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QLH_A_T27A555_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 1v40 GLUTATHIONE-REQUIRIN
G PROSTAGLANDIN D
SYNTHASE
(Homo
sapiens) 		5 / 12 PRO A  52
LEU A   6
TYR A   8
PRO A 195
TYR A  29
 GSH  A3200 ( 4.5A)
None
None
None
None
 1.36A 3qlhA-1v40A:
0.0		 3qlhA-1v40A:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QLH_A_T27A555_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 2on5 NA GLUTATHIONE
S-TRANSFERASE 2
(Necator
americanus) 		5 / 12 PRO A  52
LEU A   6
TYR A   8
PRO A 202
TYR A  29
 GSH  A 999 ( 4.6A)
None
GSH  A 999 (-4.9A)
None
EDO  A 427 (-3.6A)
 1.40A 3qlhA-2on5A:
1.3		 3qlhA-2on5A:
16.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R24_A_SAMA302_1
(2'-O-METHYL
TRANSFERASE)		 1qgj PEROXIDASE N
(Arabidopsis
thaliana) 		3 / 3 TYR A 262
ASP A 157
ASP A 272
 None
GSH  A1794 (-4.1A)
GSH  A1794 ( 4.2A)
 0.82A 3r24A-1qgjA:
undetectable		 3r24A-1qgjA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9T_C_BEZC264_0
(ECHA1_1)		 3m3m GLUTATHIONE
S-TRANSFERASE
(Pseudomonas
protegens) 		4 / 5 ALA A 164
GLU A 103
GLU A  98
ALA A 107
 None
GSH  A 209 ( 4.9A)
None
None
 1.40A 3r9tC-3m3mA:
undetectable		 3r9tC-3m3mA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ROD_A_NCAA302_0
(NICOTINAMIDE
N-METHYLTRANSFERASE)		 3ein GLUTATHIONE
S-TRANSFERASE 1-1
(Drosophila
melanogaster) 		5 / 8 LEU A  98
ASP A 101
ALA A 159
SER A  15
SER A  66
 None
None
None
None
GSH  A 210 (-2.6A)
 1.38A 3rodA-3einA:
undetectable		 3rodA-3einA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ROD_A_NCAA302_0
(NICOTINAMIDE
N-METHYLTRANSFERASE)		 4i97 DELTA CLASS 1
GLUTATHIONE
S-TRANSFERASE
(Scaptomyza
nigrita) 		5 / 8 LEU A  98
ASP A 101
ALA A 159
SER A  15
SER A  66
 None
None
None
None
GSH  A 301 (-2.7A)
 1.37A 3rodA-4i97A:
undetectable		 3rodA-4i97A:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ROD_A_NCAA302_0
(NICOTINAMIDE
N-METHYLTRANSFERASE)		 5zwp GLUTATHIONE
S-TRANSFERASE 1
(Musca
domestica) 		5 / 8 LEU A  97
ASP A 100
ALA A 158
SER A  14
SER A  65
 None
None
None
None
GSH  A 301 (-2.6A)
 1.39A 3rodA-5zwpA:
undetectable		 3rodA-5zwpA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ROD_B_NCAB302_0
(NICOTINAMIDE
N-METHYLTRANSFERASE)		 3ein GLUTATHIONE
S-TRANSFERASE 1-1
(Drosophila
melanogaster) 		5 / 9 LEU A  98
ASP A 101
ALA A 159
SER A  15
SER A  66
 None
None
None
None
GSH  A 210 (-2.6A)
 1.44A 3rodB-3einA:
0.0		 3rodB-3einA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ROD_B_NCAB302_0
(NICOTINAMIDE
N-METHYLTRANSFERASE)		 4i97 DELTA CLASS 1
GLUTATHIONE
S-TRANSFERASE
(Scaptomyza
nigrita) 		5 / 9 LEU A  98
ASP A 101
ALA A 159
SER A  15
SER A  66
 None
None
None
None
GSH  A 301 (-2.7A)
 1.44A 3rodB-4i97A:
undetectable		 3rodB-4i97A:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ROD_B_NCAB302_0
(NICOTINAMIDE
N-METHYLTRANSFERASE)		 5zwp GLUTATHIONE
S-TRANSFERASE 1
(Musca
domestica) 		5 / 9 LEU A  97
ASP A 100
ALA A 158
SER A  14
SER A  65
 None
None
None
None
GSH  A 301 (-2.6A)
 1.46A 3rodB-5zwpA:
undetectable		 3rodB-5zwpA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S68_A_SAMA228_0
(CATECHOL
O-METHYLTRANSFERASE)		 5g5f TAU CLASS
GLUTATHIONE
S-TRANSFERASE
(Mangifera
indica) 		5 / 10 GLU A  36
GLY A  10
SER A  42
GLU A  35
SER A  14
 None
None
None
None
GSH  A1222 (-2.5A)
 1.39A 3s68A-5g5fA:
undetectable		 3s68A-5g5fA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SP6_A_IL2A901_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		 4pqi IN2-1 FAMILY
PROTEIN, GLUTATHIONE
TRANSFERASE LAMBDA3
(Populus
trichocarpa) 		5 / 12 PHE A  43
CYH A  41
THR A  40
TYR A 235
TYR A 139
 GSH  A 301 (-3.8A)
GSH  A 301 (-2.0A)
None
None
None
 1.29A 3sp6A-4pqiA:
undetectable		 3sp6A-4pqiA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SP6_A_IL2A901_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		 4qq7 PUTATIVE STRINGENT
STARVATION PROTEIN A
(Burkholderia
cenocepacia) 		5 / 12 PHE A  12
CYH A  10
VAL A  32
VAL A 105
TYR A 166
 GSH  A 301 (-3.7A)
GSH  A 301 (-3.4A)
None
None
None
 1.34A 3sp6A-4qq7A:
undetectable		 3sp6A-4qq7A:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SP9_A_IL2A901_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR DELTA)		 4pqi IN2-1 FAMILY
PROTEIN, GLUTATHIONE
TRANSFERASE LAMBDA3
(Populus
trichocarpa) 		5 / 12 LEU A  35
PHE A  43
CYH A  41
THR A  40
TYR A 139
 None
GSH  A 301 (-3.8A)
GSH  A 301 (-2.0A)
None
None
 0.99A 3sp9A-4pqiA:
undetectable		 3sp9A-4pqiA:
24.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SP9_B_IL2B901_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR DELTA)		 4pqi IN2-1 FAMILY
PROTEIN, GLUTATHIONE
TRANSFERASE LAMBDA3
(Populus
trichocarpa) 		5 / 12 LEU A  35
PHE A  43
CYH A  41
THR A  40
TYR A 139
 None
GSH  A 301 (-3.8A)
GSH  A 301 (-2.0A)
None
None
 0.99A 3sp9B-4pqiA:
undetectable		 3sp9B-4pqiA:
24.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TOP_A_ACRA1_1
(MALTASE-GLUCOAMYLASE
, INTESTINAL)		 4ysl BETA-LACTAMASE
DOMAIN PROTEIN
(Pseudomonas
putida) 		5 / 12 ASP A  78
ILE A  35
ASP A  36
ASP A 170
PHE A 173
 GSH  A 302 ( 4.4A)
None
None
FE  A 301 ( 3.1A)
GSH  A 302 ( 4.9A)
 1.42A 3topA-4yslA:
undetectable		 3topA-4yslA:
16.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TTR_A_LQZA90_1
(LACTOTRANSFERRIN)		 3ein GLUTATHIONE
S-TRANSFERASE 1-1
(Drosophila
melanogaster) 		3 / 3 PRO A  54
THR A  55
LEU A  32
 GSH  A 210 (-4.3A)
None
None
 0.70A 3ttrA-3einA:
undetectable		 3ttrA-3einA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TTR_A_LQZA90_1
(LACTOTRANSFERRIN)		 4i97 DELTA CLASS 1
GLUTATHIONE
S-TRANSFERASE
(Scaptomyza
nigrita) 		3 / 3 PRO A  54
THR A  55
LEU A  32
 GSH  A 301 ( 4.6A)
None
None
 0.75A 3ttrA-4i97A:
undetectable		 3ttrA-4i97A:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UQ6_A_ADNA401_2
(ADENOSINE KINASE,
PUTATIVE)		 3lfl GLUTATHIONE
S-TRANSFERASE
OMEGA-1
(Homo
sapiens) 		4 / 5 LEU A  56
ALA A 235
PHE A 224
ASN A 231
 GSH  A 241 (-3.7A)
None
None
None
 1.36A 3uq6A-3lflA:
undetectable		 3uq6A-3lflA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_C_T1CC401_1
(TETX2 PROTEIN)		 5uuo GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN
(Novosphingobium
aromaticivorans) 		5 / 11 ASP B 252
ASN B  58
ARG B 261
GLY B  55
GLY B 221
 None
GSH  B 302 ( 2.9A)
None
EDO  B 306 ( 3.0A)
None
 1.43A 3v3oC-5uuoB:
undetectable		 3v3oC-5uuoB:
12.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_A_ACTA503_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 4jbb PUTATIVE GLUTATHIONE
S-TRANSFERASE
(Klebsiella
pneumoniae) 		3 / 3 ARG A 110
GLU A  77
THR A  76
 GSH  A 301 (-4.8A)
None
None
 0.89A 3v4tA-4jbbA:
undetectable		 3v4tA-4jbbA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAQ_A_ADNA401_2
(PUTATIVE ADENOSINE
KINASE)		 3lfl GLUTATHIONE
S-TRANSFERASE
OMEGA-1
(Homo
sapiens) 		4 / 4 LEU A  56
ALA A 235
PHE A 224
ASN A 231
 GSH  A 241 (-3.7A)
None
None
None
 1.39A 3vaqA-3lflA:
undetectable		 3vaqA-3lflA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAS_A_ADNA401_2
(PUTATIVE ADENOSINE
KINASE)		 3lfl GLUTATHIONE
S-TRANSFERASE
OMEGA-1
(Homo
sapiens) 		4 / 4 LEU A  56
ALA A 235
PHE A 224
ASN A 231
 GSH  A 241 (-3.7A)
None
None
None
 1.38A 3vasA-3lflA:
undetectable		 3vasA-3lflA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VKX_A_T3A301_1
(PROLIFERATING CELL
NUCLEAR ANTIGEN)		 2ime 2-HYDROXYCHROMENE-2-
CARBOXYLATE
ISOMERASE
(Pseudomonas
putida) 		4 / 6 LEU A  10
PRO A  12
PRO A  81
TYR A  84
 2C2  A 305 ( 4.2A)
GSH  A 301 ( 4.5A)
None
TOH  A 304 (-4.0A)
 1.47A 3vkxA-2imeA:
undetectable		 3vkxA-2imeA:
24.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VLN_A_ASCA904_0
(GLUTATHIONE
S-TRANSFERASE
OMEGA-1)		 1oyj GLUTATHIONE
S-TRANSFERASE
(Oryza
sativa) 		5 / 6 PHE A  17
ARG A  20
PRO A  57
GLU A  68
SER A  69
 GSH  A 799 (-4.0A)
None
GSH  A 799 (-4.2A)
GSH  A 799 (-2.7A)
GSH  A 799 (-2.6A)
 0.37A 3vlnA-1oyjA:
23.3		 3vlnA-1oyjA:
25.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VLN_A_ASCA904_0
(GLUTATHIONE
S-TRANSFERASE
OMEGA-1)		 1u3i GLUTATHIONE
S-TRANSFERASE 28 KDA
(Schistosoma
mansoni) 		4 / 6 ARG A  16
LEU A  69
PRO A  54
SER A  71
 GSH  A 301 (-4.2A)
None
GSH  A 301 (-4.4A)
GSH  A 301 (-2.4A)
 1.35A 3vlnA-1u3iA:
17.2		 3vlnA-1u3iA:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VLN_A_ASCA904_0
(GLUTATHIONE
S-TRANSFERASE
OMEGA-1)		 2jl4 MALEYLPYRUVATE
ISOMERASE
(Ralstonia
sp.
U2) 		4 / 6 ARG A  14
LEU A  51
PRO A  53
SER A  65
 GSH  A1213 (-4.2A)
GSH  A1213 (-3.6A)
GSH  A1213 ( 4.7A)
GSH  A1213 (-2.7A)
 0.85A 3vlnA-2jl4A:
19.4		 3vlnA-2jl4A:
26.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VLN_A_ASCA904_0
(GLUTATHIONE
S-TRANSFERASE
OMEGA-1)		 3ir4 GLUTAREDOXIN 2
(Salmonella
enterica) 		4 / 6 PHE A  11
PRO A  49
GLU A  61
SER A  62
 GSH  A 216 (-3.8A)
GSH  A 216 (-4.3A)
GSH  A 216 (-3.2A)
GSH  A 216 (-2.6A)
 0.24A 3vlnA-3ir4A:
15.0		 3vlnA-3ir4A:
24.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3VLN_A_ASCA904_0
(GLUTATHIONE
S-TRANSFERASE
OMEGA-1)		 3lfl GLUTATHIONE
S-TRANSFERASE
OMEGA-1
(Homo
sapiens) 		6 / 6 PHE A  34
ARG A  37
LEU A  71
PRO A  73
GLU A  85
SER A  86
 GSH  A 241 (-3.6A)
None
GSH  A 241 (-3.6A)
GSH  A 241 (-4.5A)
GSH  A 241 (-3.0A)
GSH  A 241 (-2.5A)
 0.31A 3vlnA-3lflA:
36.9		 3vlnA-3lflA:
99.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VLN_A_ASCA904_0
(GLUTATHIONE
S-TRANSFERASE
OMEGA-1)		 3lsz GLUTATHIONE
S-TRANSFERASE
(Rhodobacter
sphaeroides) 		4 / 6 ARG A  14
PRO A  64
GLU A  75
SER A  76
 GSH  A 300 ( 4.8A)
GSH  A 300 ( 4.6A)
GSH  A 300 (-3.1A)
GSH  A 300 (-2.7A)
 0.68A 3vlnA-3lszA:
18.3		 3vlnA-3lszA:
23.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3VLN_A_ASCA904_0
(GLUTATHIONE
S-TRANSFERASE
OMEGA-1)		 3q19 GLUTATHIONE
S-TRANSFERASE
OMEGA-2
(Homo
sapiens) 		4 / 6 ARG A  37
PRO A  73
GLU A  85
SER A  86
 None
GSH  A 240 (-4.8A)
GSH  A 240 (-3.7A)
GSH  A 240 (-2.7A)
 0.81A 3vlnA-3q19A:
33.1		 3vlnA-3q19A:
64.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3VLN_A_ASCA904_0
(GLUTATHIONE
S-TRANSFERASE
OMEGA-1)		 3wd6 OMEGA-CLASS
GLUTATHIONE
S-TRANSFERASE
(Bombyx
mori) 		4 / 6 ARG A  43
PRO A  79
GLU A  91
SER A  92
 None
GSH  A 306 (-4.3A)
GSH  A 306 (-3.0A)
GSH  A 306 (-2.6A)
 0.28A 3vlnA-3wd6A:
29.0		 3vlnA-3wd6A:
38.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VLN_A_ASCA904_0
(GLUTATHIONE
S-TRANSFERASE
OMEGA-1)		 4ags THIOL-DEPENDENT
REDUCTASE 1
(Leishmania
infantum) 		5 / 6 PHE A  16
ARG A  19
PRO A  56
GLU A  70
SER A  71
 GSH  A1450 (-3.6A)
None
GSH  A1450 (-4.5A)
GSH  A1450 (-3.1A)
GSH  A1450 (-2.5A)
 0.38A 3vlnA-4agsA:
24.0		 3vlnA-4agsA:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VLN_A_ASCA904_0
(GLUTATHIONE
S-TRANSFERASE
OMEGA-1)		 4ags THIOL-DEPENDENT
REDUCTASE 1
(Leishmania
infantum) 		5 / 6 PHE A 242
ARG A 245
PRO A 281
GLU A 293
SER A 294
 GSH  A1449 (-3.5A)
None
GSH  A1449 (-4.4A)
GSH  A1449 (-3.1A)
GSH  A1449 (-2.5A)
 0.29A 3vlnA-4agsA:
24.0		 3vlnA-4agsA:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VLN_A_ASCA904_0
(GLUTATHIONE
S-TRANSFERASE
OMEGA-1)		 4g10 GLUTATHIONE
S-TRANSFERASE
HOMOLOG
(Sphingomonas
paucimobilis) 		5 / 6 PHE A  17
ARG A  20
PRO A  58
GLU A  70
SER A  71
 GSH  A 300 (-3.6A)
None
GSH  A 300 (-4.2A)
GSH  A 300 (-3.0A)
GSH  A 300 (-2.6A)
 0.46A 3vlnA-4g10A:
21.6		 3vlnA-4g10A:
26.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VLN_A_ASCA904_0
(GLUTATHIONE
S-TRANSFERASE
OMEGA-1)		 4hoj REGF PROTEIN
(Neisseria
gonorrhoeae) 		4 / 6 PHE A  12
ARG A  15
PRO A  51
SER A  63
 GSH  A 302 (-3.8A)
None
GSH  A 302 (-4.2A)
GSH  A 302 (-2.7A)
 0.37A 3vlnA-4hojA:
21.5		 3vlnA-4hojA:
29.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VLN_A_ASCA904_0
(GLUTATHIONE
S-TRANSFERASE
OMEGA-1)		 4hoj REGF PROTEIN
(Neisseria
gonorrhoeae) 		4 / 6 PHE A  12
PRO A  51
GLU A  62
SER A  63
 GSH  A 302 (-3.8A)
GSH  A 302 (-4.2A)
GSH  A 302 (-2.8A)
GSH  A 302 (-2.7A)
 0.66A 3vlnA-4hojA:
21.5		 3vlnA-4hojA:
29.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VLN_A_ASCA904_0
(GLUTATHIONE
S-TRANSFERASE
OMEGA-1)		 4iel GLUTATHIONE
S-TRANSFERASE,
N-TERMINAL DOMAIN
PROTEIN
(Burkholderia
ambifaria) 		4 / 6 LEU A  52
PRO A  54
GLU A  65
SER A  66
 GSH  A 301 (-3.9A)
GSH  A 301 (-4.5A)
GSH  A 301 (-3.1A)
GSH  A 301 (-2.6A)
 0.46A 3vlnA-4ielA:
20.1		 3vlnA-4ielA:
24.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VLN_A_ASCA904_0
(GLUTATHIONE
S-TRANSFERASE
OMEGA-1)		 4isd GLUTATHIONE
S-TRANSFERASE
(Burkholderia
glumae) 		4 / 6 PHE A  18
PRO A  60
GLU A  71
SER A  72
 GSH  A 301 (-4.2A)
GSH  A 301 (-4.4A)
GSH  A 301 (-3.1A)
GSH  A 301 (-2.7A)
 0.34A 3vlnA-4isdA:
4.0		 3vlnA-4isdA:
24.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VLN_A_ASCA904_0
(GLUTATHIONE
S-TRANSFERASE
OMEGA-1)		 4kh7 GLUTATHIONE
S-TRANSFERASE FAMILY
PROTEIN
(Salmonella
enterica) 		4 / 6 LEU A  52
PRO A  54
GLU A  67
SER A  68
 GSH  A 301 (-3.3A)
GSH  A 301 (-4.4A)
GSH  A 301 (-2.3A)
GSH  A 301 (-2.7A)
 0.51A 3vlnA-4kh7A:
21.4		 3vlnA-4kh7A:
25.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VLN_A_ASCA904_0
(GLUTATHIONE
S-TRANSFERASE
OMEGA-1)		 4nhw GLUTATHIONE
S-TRANSFERASE
(Sinorhizobium
meliloti) 		5 / 6 ARG A  14
LEU A  62
PRO A  64
GLU A  75
SER A  76
 GSH  A 301 ( 4.9A)
GSH  A 301 (-3.7A)
GSH  A 301 (-4.2A)
GSH  A 301 (-3.0A)
GSH  A 301 (-2.5A)
 0.63A 3vlnA-4nhwA:
19.4		 3vlnA-4nhwA:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VLN_A_ASCA904_0
(GLUTATHIONE
S-TRANSFERASE
OMEGA-1)		 4pqh GLUTATHIONE
TRANSFERASE LAMBDA1
(Populus
trichocarpa) 		4 / 6 ARG A  41
PRO A  80
GLU A  91
SER A  92
 None
GSH  A 300 (-4.1A)
GSH  A 300 (-3.0A)
GSH  A 300 (-2.6A)
 0.36A 3vlnA-4pqhA:
22.8		 3vlnA-4pqhA:
29.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VLN_A_ASCA904_0
(GLUTATHIONE
S-TRANSFERASE
OMEGA-1)		 4pqi IN2-1 FAMILY
PROTEIN, GLUTATHIONE
TRANSFERASE LAMBDA3
(Populus
trichocarpa) 		5 / 6 PHE A  43
ARG A  46
PRO A  85
GLU A  96
SER A  97
 GSH  A 301 (-3.8A)
None
GSH  A 301 (-4.5A)
GSH  A 301 (-3.2A)
GSH  A 301 (-2.7A)
 0.36A 3vlnA-4pqiA:
24.1		 3vlnA-4pqiA:
29.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VLN_A_ASCA904_0
(GLUTATHIONE
S-TRANSFERASE
OMEGA-1)		 4q5n GLUTHATIONE
S-TRANSFERASE BLO T
8 ISOFORM
(Blomia
tropicalis) 		4 / 6 PHE A  14
PRO A  65
GLU A  76
SER A  77
 GSH  A 401 (-4.2A)
GSH  A 401 ( 4.8A)
GSH  A 401 (-2.9A)
GSH  A 401 (-2.9A)
 0.51A 3vlnA-4q5nA:
18.8		 3vlnA-4q5nA:
23.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VLN_A_ASCA904_0
(GLUTATHIONE
S-TRANSFERASE
OMEGA-1)		 4qq7 PUTATIVE STRINGENT
STARVATION PROTEIN A
(Burkholderia
cenocepacia) 		4 / 6 PHE A  12
ARG A  15
PRO A  51
SER A  63
 GSH  A 301 (-3.7A)
None
GSH  A 301 (-4.2A)
GSH  A 301 (-2.5A)
 0.36A 3vlnA-4qq7A:
21.0		 3vlnA-4qq7A:
29.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VLN_A_ASCA904_0
(GLUTATHIONE
S-TRANSFERASE
OMEGA-1)		 4qq7 PUTATIVE STRINGENT
STARVATION PROTEIN A
(Burkholderia
cenocepacia) 		4 / 6 PHE A  12
PRO A  51
GLU A  62
SER A  63
 GSH  A 301 (-3.7A)
GSH  A 301 (-4.2A)
GSH  A 301 (-3.1A)
GSH  A 301 (-2.5A)
 0.81A 3vlnA-4qq7A:
21.0		 3vlnA-4qq7A:
29.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VLN_A_ASCA904_0
(GLUTATHIONE
S-TRANSFERASE
OMEGA-1)		 4ri6 PHI CLASS
GLUTATHIONE
TRANSFERASE GSTF1
(Populus
tremula
x
Populus
tremuloides) 		4 / 6 ARG A  18
PRO A  57
GLU A  68
SER A  69
 None
GSH  A 500 (-4.5A)
GSH  A 500 (-2.3A)
GSH  A 500 (-2.6A)
 0.94A 3vlnA-4ri6A:
21.1		 3vlnA-4ri6A:
26.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VLN_A_ASCA904_0
(GLUTATHIONE
S-TRANSFERASE
OMEGA-1)		 4uss GLUTATHIONYL
HYDROQUINONE
REDUCTASE
(Populus
trichocarpa) 		4 / 6 ARG A  54
PRO A 130
GLU A 144
SER A 145
 None
GSH  A 500 (-4.3A)
GSH  A 500 (-2.8A)
GSH  A 500 (-2.7A)
 0.80A 3vlnA-4ussA:
17.6		 3vlnA-4ussA:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VLN_A_ASCA904_0
(GLUTATHIONE
S-TRANSFERASE
OMEGA-1)		 5eco GLUTATHIONE
S-TRANSFERASE U20
(Arabidopsis
thaliana) 		4 / 6 ARG B  18
PRO B  55
GLU B  66
SER B  67
 None
None
None
GSH  B 301 (-3.2A)
 0.88A 3vlnA-5ecoB:
22.2		 3vlnA-5ecoB:
28.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VLN_A_ASCA904_0
(GLUTATHIONE
S-TRANSFERASE
OMEGA-1)		 5eco GLUTATHIONE
S-TRANSFERASE U20
(Arabidopsis
thaliana) 		4 / 6 PHE B  15
ARG B  18
PRO B  55
SER B  67
 GSH  B 301 (-3.7A)
None
None
GSH  B 301 (-3.2A)
 0.39A 3vlnA-5ecoB:
22.2		 3vlnA-5ecoB:
28.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VLN_A_ASCA904_0
(GLUTATHIONE
S-TRANSFERASE
OMEGA-1)		 5f05 PHI CLASS
GLUTATHIONE
TRANSFERASE GSTF5
(Populus
trichocarpa) 		4 / 6 ARG A  17
PRO A  56
GLU A  67
SER A  68
 GSH  A 301 ( 4.9A)
GSH  A 301 ( 4.6A)
GSH  A 301 (-2.6A)
GSH  A 301 (-2.5A)
 0.96A 3vlnA-5f05A:
20.7		 3vlnA-5f05A:
26.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VLN_A_ASCA904_0
(GLUTATHIONE
S-TRANSFERASE
OMEGA-1)		 5f06 GLUTATHIONE
S-TRANSFERASE FAMILY
PROTEIN
(Populus
trichocarpa) 		4 / 6 ARG A  16
PRO A  55
GLU A  66
SER A  67
 GSH  A 301 ( 4.9A)
GSH  A 301 ( 4.8A)
GSH  A 301 (-2.8A)
GSH  A 301 (-2.7A)
 0.98A 3vlnA-5f06A:
20.0		 3vlnA-5f06A:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VLN_A_ASCA904_0
(GLUTATHIONE
S-TRANSFERASE
OMEGA-1)		 5f07 PUTATIVE GLUTATHIONE
S-TRANSFERASE FAMILY
PROTEIN
(Populus
trichocarpa) 		4 / 6 ARG A  16
PRO A  55
GLU A  66
SER A  67
 None
GSH  A 301 ( 4.6A)
GSH  A 301 (-2.7A)
GSH  A 301 (-2.7A)
 0.92A 3vlnA-5f07A:
21.3		 3vlnA-5f07A:
25.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VLN_A_ASCA904_0
(GLUTATHIONE
S-TRANSFERASE
OMEGA-1)		 5g5a GLUTATHIONE
S-TRANSFERASE U25
(Arabidopsis
thaliana) 		5 / 6 PHE A  15
ARG A  18
PRO A  55
GLU A  66
SER A  67
 GSH  A1221 (-4.4A)
GSH  A1221 ( 4.9A)
GSH  A1221 (-4.3A)
GSH  A1221 (-3.0A)
GSH  A1221 (-2.6A)
 0.44A 3vlnA-5g5aA:
24.4		 3vlnA-5g5aA:
29.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VLN_A_ASCA904_0
(GLUTATHIONE
S-TRANSFERASE
OMEGA-1)		 5g5f TAU CLASS
GLUTATHIONE
S-TRANSFERASE
(Mangifera
indica) 		4 / 6 ARG A  19
PRO A  56
GLU A  67
SER A  68
 None
GSH  A1222 (-4.3A)
GSH  A1222 (-3.1A)
GSH  A1222 (-2.4A)
 0.36A 3vlnA-5g5fA:
23.7		 3vlnA-5g5fA:
29.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VLN_A_ASCA904_0
(GLUTATHIONE
S-TRANSFERASE
OMEGA-1)		 5j4u GLUTATHIONE
TRANSFERASE FAMILY
PROTEIN
(Populus
trichocarpa) 		5 / 6 PHE A  16
ARG A  19
PRO A  56
GLU A  67
SER A  68
 GSH  A 301 (-3.9A)
None
GSH  A 301 (-4.4A)
GSH  A 301 (-3.2A)
GSH  A 301 (-2.7A)
 0.31A 3vlnA-5j4uA:
24.2		 3vlnA-5j4uA:
28.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VLN_A_ASCA904_0
(GLUTATHIONE
S-TRANSFERASE
OMEGA-1)		 5n9u DEHYDROASCORBATE
REDUCTASE FAMILY
PROTEIN
(Populus
trichocarpa) 		4 / 6 PHE A  22
ARG A  25
PRO A  61
SER A  73
 GSH  A 301 (-3.0A)
GSH  A 301 ( 4.7A)
GSH  A 301 (-4.0A)
GSH  A 301 (-2.5A)
 0.40A 3vlnA-5n9uA:
19.7		 3vlnA-5n9uA:
26.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W2T_A_LF7A801_1
(DIPEPTIDYL PEPTIDASE
4)		 5f06 GLUTATHIONE
S-TRANSFERASE FAMILY
PROTEIN
(Populus
trichocarpa) 		5 / 12 ARG A  68
GLU A 104
TYR A 176
VAL A 116
ASN A 109
 GSH  A 301 (-4.0A)
None
None
None
None
 1.45A 3w2tA-5f06A:
undetectable		 3w2tA-5f06A:
13.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W2T_B_LF7B801_1
(DIPEPTIDYL PEPTIDASE
4)		 5f06 GLUTATHIONE
S-TRANSFERASE FAMILY
PROTEIN
(Populus
trichocarpa) 		5 / 12 ARG A  68
GLU A 104
TYR A 176
VAL A 116
ASN A 109
 GSH  A 301 (-4.0A)
None
None
None
None
 1.42A 3w2tB-5f06A:
undetectable		 3w2tB-5f06A:
13.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W68_B_VIVB301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 3vwx GLUTATHIONE
S-TRANSFERASE 6B
(Musca
domestica) 		5 / 12 ILE A 115
VAL A 213
VAL A  15
LEU A  36
VAL A  55
 None
None
None
GSH  A 500 (-4.4A)
GSH  A 500 (-3.9A)
 1.13A 3w68B-3vwxA:
undetectable		 3w68B-3vwxA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1476_0
(MJ0495-LIKE PROTEIN)		 1pd2 HEMATOPOIETIC
PROSTAGLANDIN D
SYNTHASE
(Rattus
norvegicus) 		4 / 5 ILE 1  51
ALA 1  15
HIS 1  32
ARG 1  33
 GSH  1 301 (-4.6A)
None
None
None
 0.80A 4ac9B-1pd21:
undetectable
4ac9C-1pd21:
undetectable		 4ac9B-1pd21:
16.36
4ac9C-1pd21:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1476_0
(MJ0495-LIKE PROTEIN)		 1v40 GLUTATHIONE-REQUIRIN
G PROSTAGLANDIN D
SYNTHASE
(Homo
sapiens) 		4 / 5 ILE A  51
ALA A  15
HIS A  32
ARG A  33
 GSH  A3200 (-4.2A)
None
None
None
 0.86A 4ac9B-1v40A:
undetectable
4ac9C-1v40A:
undetectable		 4ac9B-1v40A:
19.29
4ac9C-1v40A:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_C_DXCC1476_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 1pd2 HEMATOPOIETIC
PROSTAGLANDIN D
SYNTHASE
(Rattus
norvegicus) 		4 / 5 ILE 1  51
ALA 1  15
HIS 1  32
ARG 1  33
 GSH  1 301 (-4.6A)
None
None
None
 0.83A 4acaB-1pd21:
undetectable
4acaC-1pd21:
undetectable		 4acaB-1pd21:
16.36
4acaC-1pd21:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_C_DXCC1476_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 1v40 GLUTATHIONE-REQUIRIN
G PROSTAGLANDIN D
SYNTHASE
(Homo
sapiens) 		4 / 5 ILE A  51
ALA A  15
HIS A  32
ARG A  33
 GSH  A3200 (-4.2A)
None
None
None
 0.90A 4acaB-1v40A:
undetectable
4acaC-1v40A:
undetectable		 4acaB-1v40A:
19.29
4acaC-1v40A:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZS_A_SAMA1475_0
(METHYLTRANSFERASE
WBDD)		 1typ TRYPANOTHIONE
REDUCTASE
(Crithidia
fasciculata) 		5 / 12 TYR A 110
GLY A  16
ALA A  12
ILE A 325
GLU A 341
 GSH  A 497 ( 4.0A)
None
None
None
None
 1.21A 4azsA-1typA:
2.8		 4azsA-1typA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BZ6_A_SHHA700_1
(HISTONE DEACETYLASE
8)		 4ysl BETA-LACTAMASE
DOMAIN PROTEIN
(Pseudomonas
putida) 		5 / 10 HIS A  74
HIS A  76
ASP A 170
HIS A 212
GLY A 169
 FE  A 301 (-3.4A)
None
FE  A 301 ( 3.1A)
GSH  A 302 ( 4.8A)
None
 1.45A 4bz6A-4yslA:
undetectable		 4bz6A-4yslA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BZ6_B_SHHB700_1
(HISTONE DEACETYLASE
8)		 4ysl BETA-LACTAMASE
DOMAIN PROTEIN
(Pseudomonas
putida) 		5 / 12 HIS A  74
HIS A  76
ASP A 170
HIS A 212
GLY A 169
 FE  A 301 (-3.4A)
None
FE  A 301 ( 3.1A)
GSH  A 302 ( 4.8A)
None
 1.44A 4bz6A-4yslA:
undetectable
4bz6B-4yslA:
undetectable		 4bz6A-4yslA:
23.21
4bz6B-4yslA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BZ6_C_SHHC700_1
(HISTONE DEACETYLASE
8)		 4ysl BETA-LACTAMASE
DOMAIN PROTEIN
(Pseudomonas
putida) 		5 / 12 HIS A 149
GLY A 169
HIS A  76
ASP A  78
HIS A  79
 FE  A 301 ( 3.5A)
None
None
GSH  A 302 ( 4.4A)
None
 1.28A 4bz6C-4yslA:
undetectable		 4bz6C-4yslA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BZ6_D_SHHD700_1
(HISTONE DEACETYLASE
8)		 4ysl BETA-LACTAMASE
DOMAIN PROTEIN
(Pseudomonas
putida) 		5 / 10 HIS A  74
HIS A  76
ASP A 170
HIS A 212
GLY A 169
 FE  A 301 (-3.4A)
None
FE  A 301 ( 3.1A)
GSH  A 302 ( 4.8A)
None
 1.46A 4bz6D-4yslA:
undetectable		 4bz6D-4yslA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C1H_A_X8ZA305_1
(BETA-LACTAMASE 2)		 1qh5 PROTEIN
(HYDROXYACYLGLUTATHI
ONE HYDROLASE)
(Homo
sapiens) 		5 / 9 HIS A  56
ASP A  58
HIS A  54
GLY A 142
HIS A 173
 ZN  A 261 ( 3.3A)
ZN  A 262 (-2.7A)
ZN  A 261 ( 3.4A)
GSH  A 463 (-3.5A)
ZN  A 262 (-3.3A)
 1.01A 4c1hA-1qh5A:
16.4		 4c1hA-1qh5A:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D33_A_MTLA870_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 1pd2 HEMATOPOIETIC
PROSTAGLANDIN D
SYNTHASE
(Rattus
norvegicus) 		4 / 8 SER 1  64
ARG 1  14
ILE 1  17
TRP 1 148
 GSH  1 301 (-2.6A)
GSH  1 301 (-3.4A)
None
None
 0.93A 4d33A-1pd21:
undetectable		 4d33A-1pd21:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D33_A_MTLA870_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5g5a GLUTATHIONE
S-TRANSFERASE U25
(Arabidopsis
thaliana) 		4 / 8 SER A  67
ARG A  18
GLU A  72
ILE A  71
 GSH  A1221 (-2.6A)
GSH  A1221 ( 4.9A)
None
None
 1.15A 4d33A-5g5aA:
undetectable		 4d33A-5g5aA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D39_A_ACTA860_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2pvq GLUTATHIONE
S-TRANSFERASE
(Ochrobactrum
anthropi) 		4 / 4 GLY A   8
TRP A 164
VAL A 160
SER A  11
 GSH  A5204 (-3.5A)
GSH  A5204 (-4.0A)
None
None
 1.49A 4d39A-2pvqA:
0.2		 4d39A-2pvqA:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D39_A_MTLA870_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 1pd2 HEMATOPOIETIC
PROSTAGLANDIN D
SYNTHASE
(Rattus
norvegicus) 		4 / 8 SER 1  64
ARG 1  14
ILE 1  17
TRP 1 148
 GSH  1 301 (-2.6A)
GSH  1 301 (-3.4A)
None
None
 0.92A 4d39A-1pd21:
0.0		 4d39A-1pd21:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D39_A_MTLA870_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 1v40 GLUTATHIONE-REQUIRIN
G PROSTAGLANDIN D
SYNTHASE
(Homo
sapiens) 		4 / 8 SER A  64
ARG A  14
ILE A  17
TRP A 148
 GSH  A3200 (-2.5A)
O16  A3201 ( 3.8A)
None
None
 1.06A 4d39A-1v40A:
undetectable		 4d39A-1v40A:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DF3_A_SAMA301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 4gci GLUTATHIONE
S-TRANSFERASE
(Yersinia
pestis) 		5 / 12 GLY A  67
ALA A 157
VAL A  18
ALA A 103
VAL A  68
 GSH  A 302 (-4.0A)
None
None
None
None
 1.25A 4df3A-4gciA:
undetectable		 4df3A-4gciA:
24.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DF3_B_SAMB301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 4gci GLUTATHIONE
S-TRANSFERASE
(Yersinia
pestis) 		5 / 12 GLY A  67
ALA A 157
VAL A  18
ALA A 103
VAL A  68
 GSH  A 302 (-4.0A)
None
None
None
None
 1.25A 4df3B-4gciA:
undetectable		 4df3B-4gciA:
24.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DUB_A_LDPA501_1
(CYTOCHROME P450 BM3
VARIANT 9D7)		 4ivf PUTATIVE
UNCHARACTERIZED
PROTEIN
(Lodderomyces
elongisporus) 		4 / 6 PHE A 154
GLY A 119
PRO A 120
VAL A 115
 None
GSH  A 301 (-3.7A)
GSH  A 301 (-3.2A)
None
 0.96A 4dubA-4ivfA:
undetectable		 4dubA-4ivfA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJJ_A_NCTA501_1
(CYTOCHROME P450 2A6)		 4g19 GLUTATHIONE
TRANSFERASE GTE1
(Phanerochaete
chrysosporium) 		4 / 7 PHE A 149
ASN A  24
THR A 137
ILE A 134
 None
GSH  A 302 ( 3.8A)
None
None
 0.89A 4ejjA-4g19A:
undetectable		 4ejjA-4g19A:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EOH_A_TEPA402_1
(PYRIDOXAL KINASE)		 4z9n AMINO ACID ABC
TRANSPORTER,
PERIPLASMIC AMINO
ACID-BINDING PROTEIN
(Brucella
ovis) 		4 / 5 SER A 202
GLY A 104
THR A  85
ASP A 177
 None
None
EDO  A 403 ( 4.9A)
GSH  A 401 (-3.0A)
 1.09A 4eohA-4z9nA:
undetectable		 4eohA-4z9nA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8Y_B_VK3B202_1
(NADPH QUINONE
OXIDOREDUCTASE)		 4l5o PUTATIVE GLUTATHIONE
TRANSFERASE
(Clonorchis
sinensis) 		4 / 6 TRP A  41
ASN A  47
TYR A  57
LEU A  50
 GSH  A 301 (-4.1A)
None
None
None
 1.27A 4f8yA-4l5oA:
undetectable
4f8yB-4l5oA:
undetectable		 4f8yA-4l5oA:
18.07
4f8yB-4l5oA:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8Y_C_VK3C202_1
(NADPH QUINONE
OXIDOREDUCTASE)		 4l5o PUTATIVE GLUTATHIONE
TRANSFERASE
(Clonorchis
sinensis) 		4 / 7 TYR A  57
LEU A  50
TRP A  41
ASN A  47
 None
None
GSH  A 301 (-4.1A)
None
 1.24A 4f8yC-4l5oA:
undetectable
4f8yD-4l5oA:
undetectable		 4f8yC-4l5oA:
18.07
4f8yD-4l5oA:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEU_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 4ysl BETA-LACTAMASE
DOMAIN PROTEIN
(Pseudomonas
putida) 		4 / 7 ASP A  78
ASP A  40
GLU A  72
ASP A  14
 GSH  A 302 ( 4.4A)
None
None
None
 1.13A 4feuB-4yslA:
undetectable		 4feuB-4yslA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEU_F_KANF301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 4ysl BETA-LACTAMASE
DOMAIN PROTEIN
(Pseudomonas
putida) 		4 / 8 ASP A  78
ASP A  40
GLU A  72
ASP A  14
 GSH  A 302 ( 4.4A)
None
None
None
 1.15A 4feuF-4yslA:
undetectable		 4feuF-4yslA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEV_D_KAND301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 4ysl BETA-LACTAMASE
DOMAIN PROTEIN
(Pseudomonas
putida) 		4 / 7 ASP A  78
ASP A  40
GLU A  72
ASP A  14
 GSH  A 302 ( 4.4A)
None
None
None
 1.16A 4fevD-4yslA:
undetectable		 4fevD-4yslA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEV_F_KANF301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 4ysl BETA-LACTAMASE
DOMAIN PROTEIN
(Pseudomonas
putida) 		4 / 7 ASP A  78
ASP A  40
GLU A  72
ASP A  14
 GSH  A 302 ( 4.4A)
None
None
None
 1.16A 4fevF-4yslA:
undetectable		 4fevF-4yslA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEW_D_KAND301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 4ysl BETA-LACTAMASE
DOMAIN PROTEIN
(Pseudomonas
putida) 		4 / 8 ASP A  78
ASP A  40
GLU A  72
ASP A  14
 GSH  A 302 ( 4.4A)
None
None
None
 1.18A 4fewD-4yslA:
undetectable		 4fewD-4yslA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEW_F_KANF301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 4ysl BETA-LACTAMASE
DOMAIN PROTEIN
(Pseudomonas
putida) 		4 / 8 ASP A  78
ASP A  40
GLU A  72
ASP A  14
 GSH  A 302 ( 4.4A)
None
None
None
 1.16A 4fewF-4yslA:
undetectable		 4fewF-4yslA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEX_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 4ysl BETA-LACTAMASE
DOMAIN PROTEIN
(Pseudomonas
putida) 		4 / 7 ASP A  78
ASP A  40
GLU A  72
ASP A  14
 GSH  A 302 ( 4.4A)
None
None
None
 1.18A 4fexB-4yslA:
undetectable		 4fexB-4yslA:
21.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4G10_A_ACTA301_0
(GLUTATHIONE
S-TRANSFERASE
HOMOLOG)		 4g10 GLUTATHIONE
S-TRANSFERASE
HOMOLOG
(Sphingomonas
paucimobilis) 		6 / 6 PRO A  16
ILE A  39
TYR A 113
TYR A 214
TYR A 217
PHE A 235
 GSH  A 300 ( 4.4A)
None
ACT  A 301 (-4.5A)
ACT  A 301 (-4.5A)
None
ACT  A 301 ( 4.5A)
 0.01A 4g10A-4g10A:
45.6		 4g10A-4g10A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G10_A_ACTA301_0
(GLUTATHIONE
S-TRANSFERASE
HOMOLOG)		 5lkd GLUTATHIONE
S-TRANSFERASE
OMEGA-LIKE 2
(Saccharomyces
cerevisiae) 		4 / 6 PRO A  47
ILE A 295
TYR A 346
TYR A 301
 GSH  A 401 ( 4.6A)
None
None
None
 1.22A 4g10A-5lkdA:
16.2		 4g10A-5lkdA:
20.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4G19_A_ACTA301_0
(GLUTATHIONE
TRANSFERASE GTE1)		 4g19 GLUTATHIONE
TRANSFERASE GTE1
(Phanerochaete
chrysosporium) 		5 / 5 ASN A  24
TYR A  46
TRP A 122
PHE A 130
ARG A 153
 GSH  A 302 ( 3.8A)
GSH  A 302 ( 4.7A)
None
ACT  A 301 (-4.1A)
GSH  A 302 ( 2.4A)
 0.00A 4g19A-4g19A:
45.4		 4g19A-4g19A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4G19_B_ACTB301_0
(GLUTATHIONE
TRANSFERASE GTE1)		 4g19 GLUTATHIONE
TRANSFERASE GTE1
(Phanerochaete
chrysosporium) 		5 / 5 ASN A  24
TYR A  46
TRP A 122
PHE A 130
ARG A 153
 GSH  A 302 ( 3.8A)
GSH  A 302 ( 4.7A)
None
ACT  A 301 (-4.1A)
GSH  A 302 ( 2.4A)
 0.20A 4g19B-4g19A:
43.3		 4g19B-4g19A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4G19_C_ACTC301_0
(GLUTATHIONE
TRANSFERASE GTE1)		 4g19 GLUTATHIONE
TRANSFERASE GTE1
(Phanerochaete
chrysosporium) 		4 / 5 ASN A  24
TYR A  46
PHE A 130
ARG A 153
 GSH  A 302 ( 3.8A)
GSH  A 302 ( 4.7A)
ACT  A 301 (-4.1A)
GSH  A 302 ( 2.4A)
 0.17A 4g19C-4g19A:
43.1		 4g19C-4g19A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4G19_C_ACTC301_0
(GLUTATHIONE
TRANSFERASE GTE1)		 4g19 GLUTATHIONE
TRANSFERASE GTE1
(Phanerochaete
chrysosporium) 		4 / 5 TYR A  46
TRP A 122
PHE A 130
ARG A 153
 GSH  A 302 ( 4.7A)
None
ACT  A 301 (-4.1A)
GSH  A 302 ( 2.4A)
 0.73A 4g19C-4g19A:
43.1		 4g19C-4g19A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4G19_D_ACTD302_0
(GLUTATHIONE
TRANSFERASE GTE1)		 4g19 GLUTATHIONE
TRANSFERASE GTE1
(Phanerochaete
chrysosporium) 		3 / 3 TYR A  46
PHE A 130
ARG A 153
 GSH  A 302 ( 4.7A)
ACT  A 301 (-4.1A)
GSH  A 302 ( 2.4A)
 0.09A 4g19D-4g19A:
43.7		 4g19D-4g19A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 4ysl BETA-LACTAMASE
DOMAIN PROTEIN
(Pseudomonas
putida) 		4 / 8 ASP A  78
ASP A  40
GLU A  72
ASP A  14
 GSH  A 302 ( 4.4A)
None
None
None
 1.20A 4gkhB-4yslA:
undetectable		 4gkhB-4yslA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_F_KANF301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 4ysl BETA-LACTAMASE
DOMAIN PROTEIN
(Pseudomonas
putida) 		4 / 8 ASP A  78
ASP A  40
GLU A  72
ASP A  14
 GSH  A 302 ( 4.4A)
None
None
None
 1.16A 4gkhF-4yslA:
undetectable		 4gkhF-4yslA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_G_KANG301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 4ysl BETA-LACTAMASE
DOMAIN PROTEIN
(Pseudomonas
putida) 		4 / 7 ASP A  78
ASP A  40
GLU A  72
ASP A  14
 GSH  A 302 ( 4.4A)
None
None
None
 1.17A 4gkhG-4yslA:
undetectable		 4gkhG-4yslA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKI_A_KANA301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 4ysl BETA-LACTAMASE
DOMAIN PROTEIN
(Pseudomonas
putida) 		4 / 8 ASP A  78
ASP A  40
GLU A  72
ASP A  14
 GSH  A 302 ( 4.4A)
None
None
None
 1.17A 4gkiA-4yslA:
undetectable		 4gkiA-4yslA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKI_G_KANG301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 4ysl BETA-LACTAMASE
DOMAIN PROTEIN
(Pseudomonas
putida) 		4 / 8 ASP A  78
ASP A  40
GLU A  72
ASP A  14
 GSH  A 302 ( 4.4A)
None
None
None
 1.15A 4gkiE-4yslA:
undetectable
4gkiG-4yslA:
undetectable		 4gkiE-4yslA:
21.24
4gkiG-4yslA:
21.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4HZ2_A_BEZA302_0
(GLUTATHIONE
S-TRANSFERASE DOMAIN)		 4hz2 GLUTATHIONE
S-TRANSFERASE DOMAIN
(Xanthobacter
autotrophicus) 		6 / 6 MET A   6
SER A   9
ARG A 109
TYR A 110
TRP A 114
TYR A 164
 GSH  A 301 (-3.6A)
BEZ  A 302 (-3.1A)
BEZ  A 302 ( 4.3A)
UNL  A 303 ( 4.0A)
BEZ  A 302 (-3.5A)
BEZ  A 302 (-4.4A)
 0.01A 4hz2A-4hz2A:
39.1		 4hz2A-4hz2A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IFY_A_T27A601_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 3w8s GLUTATHIONE
S-TRANSFERASE-3
(Necator
americanus) 		5 / 12 PRO A  52
LEU A   6
TYR A   8
PRO A 202
TYR A  29
 GSH  A 301 (-4.4A)
None
None
None
None
 1.42A 4ifyA-3w8sA:
undetectable		 4ifyA-3w8sA:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IG3_A_T27A601_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 3w8s GLUTATHIONE
S-TRANSFERASE-3
(Necator
americanus) 		5 / 12 PRO A  52
LEU A   6
TYR A   8
PRO A 202
TYR A  29
 GSH  A 301 (-4.4A)
None
None
None
None
 1.39A 4ig3A-3w8sA:
undetectable		 4ig3A-3w8sA:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IIZ_A_LURA201_1
(TRANSTHYRETIN)		 5uuo GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN
(Novosphingobium
aromaticivorans) 		3 / 3 LYS B  61
LEU B 126
ALA B  62
 GSH  B 301 ( 3.9A)
None
None
 0.81A 4iizA-5uuoB:
undetectable		 4iizA-5uuoB:
25.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4IJI_H_BEZH501_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN YIBF)		 4glt GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN
(Methylobacillus
flagellatus) 		4 / 7 SER A   9
VAL A 105
TYR A 165
ARG A 169
 GSH  A 301 (-2.7A)
GSH  A 301 ( 4.8A)
GSH  A 301 (-4.7A)
GSH  A 301 (-4.1A)
 0.67A 4ijiH-4gltA:
25.9		 4ijiH-4gltA:
35.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KF9_A_ACTA406_0
(GLUTATHIONE
S-TRANSFERASE
PROTEIN)		 4kf9 GLUTATHIONE
S-TRANSFERASE
PROTEIN
(Ralstonia
solanacearum) 		4 / 4 TYR A  11
PHE A 105
ARG A 137
MET A 140
 ACT  A 408 ( 4.8A)
ACT  A 406 ( 4.9A)
GSH  A 405 (-3.5A)
GSH  A 405 ( 3.4A)
 0.00A 4kf9A-4kf9A:
55.5		 4kf9A-4kf9A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KF9_A_ACTA408_0
(GLUTATHIONE
S-TRANSFERASE
PROTEIN)		 4kf9 GLUTATHIONE
S-TRANSFERASE
PROTEIN
(Ralstonia
solanacearum) 		6 / 6 TYR A  11
THR A  13
PRO A  15
PHE A 133
ARG A 137
PHE A 195
 ACT  A 408 ( 4.8A)
ACT  A 408 (-4.7A)
GSH  A 405 ( 4.1A)
ACT  A 408 (-4.7A)
GSH  A 405 (-3.5A)
ACT  A 408 (-4.4A)
 0.00A 4kf9A-4kf9A:
55.5		 4kf9A-4kf9A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KMM_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4ri6 PHI CLASS
GLUTATHIONE
TRANSFERASE GSTF1
(Populus
tremula
x
Populus
tremuloides) 		4 / 5 LEU A 167
ARG A  74
PRO A  57
SER A  13
 None
None
GSH  A 500 (-4.5A)
GSH  A 500 ( 2.2A)
 1.45A 4kmmB-4ri6A:
undetectable		 4kmmB-4ri6A:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOS_A_4KOA201_1
(UNCHARACTERIZED
PROTEIN)		 1tu7 GLUTATHIONE
S-TRANSFERASE 2
(Onchocerca
volvulus) 		5 / 12 ARG A  95
GLY A  64
ILE A  60
ARG A  18
LEU A   5
 GSH  A1001 (-3.6A)
None
None
None
None
 1.36A 4kosA-1tu7A:
undetectable		 4kosA-1tu7A:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOT_A_CE3A205_1
(UNCHARACTERIZED
PROTEIN)		 1tu7 GLUTATHIONE
S-TRANSFERASE 2
(Onchocerca
volvulus) 		5 / 12 ARG A  95
GLY A  64
ILE A  60
ARG A  18
LEU A   5
 GSH  A1001 (-3.6A)
None
None
None
None
 1.38A 4kotA-1tu7A:
undetectable		 4kotA-1tu7A:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOY_A_CSCA214_1
(UNCHARACTERIZED
PROTEIN)		 1tu7 GLUTATHIONE
S-TRANSFERASE 2
(Onchocerca
volvulus) 		5 / 11 ARG A  95
GLY A  64
ILE A  60
ARG A  18
LEU A   5
 GSH  A1001 (-3.6A)
None
None
None
None
 1.39A 4koyA-1tu7A:
undetectable		 4koyA-1tu7A:
22.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MF6_A_BEZA303_0
(GLUTATHIONE
S-TRANSFERASE DOMAIN)		 4ikh GLUTATHIONE
S-TRANSFERASE
(Pseudomonas
protegens) 		5 / 5 THR A  28
PRO A  29
PHE A 139
ASN A 192
TYR A 197
 GSH  A 301 (-3.4A)
None
None
None
None
 0.34A 4mf6A-4ikhA:
36.3		 4mf6A-4ikhA:
68.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MF6_A_BEZA303_0
(GLUTATHIONE
S-TRANSFERASE DOMAIN)		 4mf6 GLUTATHIONE
S-TRANSFERASE DOMAIN
(Paraburkholderia
graminis) 		5 / 5 THR A  28
PRO A  29
PHE A 139
ASN A 192
TYR A 197
 GSH  A 301 (-3.3A)
GSH  A 302 ( 4.4A)
BEZ  A 303 (-3.4A)
BEZ  A 303 (-3.5A)
BEZ  A 303 (-4.2A)
 0.00A 4mf6A-4mf6A:
42.3		 4mf6A-4mf6A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MF6_A_BEZA303_0
(GLUTATHIONE
S-TRANSFERASE DOMAIN)		 4nhz PUTATIVE GLUTATHIONE
S-TRANSFERASE ENZYME
WITH
THIOREDOXIN-LIKE
DOMAIN
(Bradyrhizobium
sp.
BTAi1) 		5 / 5 THR A  28
PRO A  29
PHE A 139
ASN A 192
TYR A 197
 GSH  A 301 (-3.5A)
GSH  A 301 ( 4.9A)
None
None
None
 0.55A 4mf6A-4nhzA:
36.6		 4mf6A-4nhzA:
74.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_A_AERA601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 3ubl GLUTATHIONE
TRANSFERASE
(Leptospira
interrogans) 		4 / 5 LEU A 134
ASP A 153
GLU A  98
VAL A 162
 None
None
GSH  A 241 ( 4.9A)
None
 1.11A 4nkvA-3ublA:
undetectable		 4nkvA-3ublA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O4D_A_ACTA406_0
(INOSITOL
HEXAKISPHOSPHATE
KINASE)		 4ysl BETA-LACTAMASE
DOMAIN PROTEIN
(Pseudomonas
putida) 		4 / 7 ASP A  78
THR A  17
SER A 266
HIS A  79
 GSH  A 302 ( 4.4A)
None
None
None
 1.30A 4o4dA-4yslA:
undetectable		 4o4dA-4yslA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O8F_B_BRLB501_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 5g5a GLUTATHIONE
S-TRANSFERASE U25
(Arabidopsis
thaliana) 		4 / 6 ILE A  54
GLY A  16
ILE A 205
LEU A  37
 GSH  A1221 (-4.1A)
None
None
GSH  A1221 ( 4.1A)
 0.77A 4o8fB-5g5aA:
undetectable		 4o8fB-5g5aA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O8F_B_BRLB501_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 5g5a GLUTATHIONE
S-TRANSFERASE U25
(Arabidopsis
thaliana) 		4 / 6 PHE A  15
GLY A  16
ILE A 205
LEU A  37
 GSH  A1221 (-4.4A)
None
None
GSH  A1221 ( 4.1A)
 0.69A 4o8fB-5g5aA:
undetectable		 4o8fB-5g5aA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLF_A_HFGA802_0
(PROLINE--TRNA LIGASE)		 5ft3 GLUTATHIONE
S-TRANSFERASE
EPSILON 2
(Aedes
aegypti) 		5 / 12 VAL A  11
PRO A  13
GLU A 103
HIS A  69
GLY A 105
 None
GSH  A1221 ( 4.2A)
None
GSH  A1221 (-4.4A)
None
 1.49A 4olfA-5ft3A:
undetectable		 4olfA-5ft3A:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLF_A_HFGA802_0
(PROLINE--TRNA LIGASE)		 5ft3 GLUTATHIONE
S-TRANSFERASE
EPSILON 2
(Aedes
aegypti) 		5 / 12 VAL A 207
PRO A  13
GLU A 103
HIS A  69
GLY A 105
 None
GSH  A1221 ( 4.2A)
None
GSH  A1221 (-4.4A)
None
 1.49A 4olfA-5ft3A:
undetectable		 4olfA-5ft3A:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PCL_B_SAMB301_0
(O-METHYLTRANSFERASE
FAMILY PROTEIN)		 5elg GLUTATHIONE
S-TRANSFERASE DHAR1,
MITOCHONDRIAL
(Arabidopsis
thaliana) 		5 / 12 LEU A  27
GLY A  18
CYH A  20
ALA A   9
ASN A  43
 None
None
GSH  A 302 (-3.0A)
None
None
 1.09A 4pclB-5elgA:
undetectable		 4pclB-5elgA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PCL_B_SAMB301_0
(O-METHYLTRANSFERASE
FAMILY PROTEIN)		 5elg GLUTATHIONE
S-TRANSFERASE DHAR1,
MITOCHONDRIAL
(Arabidopsis
thaliana) 		5 / 12 LEU A  27
GLY A  18
CYH A  20
ALA A  13
ALA A   9
 None
None
GSH  A 302 (-3.0A)
None
None
 1.38A 4pclB-5elgA:
undetectable		 4pclB-5elgA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PTJ_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3w8s GLUTATHIONE
S-TRANSFERASE-3
(Necator
americanus) 		5 / 12 ILE A  67
ALA A  62
LEU A  51
ILE A  32
ARG A  19
 None
None
GSH  A 301 (-4.5A)
None
None
 1.15A 4ptjA-3w8sA:
undetectable		 4ptjA-3w8sA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA0_A_SHHA404_2
(HISTONE DEACETYLASE
8)		 4ags THIOL-DEPENDENT
REDUCTASE 1
(Leishmania
infantum) 		3 / 3 PRO A  43
MET A  42
TYR A  46
 None
GSH  A1450 (-4.2A)
None
 0.87A 4qa0B-4agsA:
undetectable		 4qa0B-4agsA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA0_B_SHHB404_1
(HISTONE DEACETYLASE
8)		 4ags THIOL-DEPENDENT
REDUCTASE 1
(Leishmania
infantum) 		3 / 3 PRO A  43
MET A  42
TYR A  46
 None
GSH  A1450 (-4.2A)
None
 0.85A 4qa0A-4agsA:
undetectable		 4qa0A-4agsA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA2_A_SHHA404_2
(HISTONE DEACETYLASE
8)		 4ags THIOL-DEPENDENT
REDUCTASE 1
(Leishmania
infantum) 		3 / 3 PRO A  43
MET A  42
TYR A  46
 None
GSH  A1450 (-4.2A)
None
 0.84A 4qa2B-4agsA:
undetectable		 4qa2B-4agsA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QLE_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4eq9 ABC TRANSPORTER
SUBSTRATE-BINDING
PROTEIN-AMINO ACID
TRANSPORT
(Streptococcus
pneumoniae) 		5 / 12 ASP A  94
LEU A  93
PHE A  90
THR A 108
LEU A 105
 None
None
None
None
GSH  A 301 (-4.7A)
 1.11A 4qleA-4eq9A:
undetectable		 4qleA-4eq9A:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_A_GCSA301_1
(CHITOSANASE)		 2gdr GLUTATHIONE
S-TRANSFERASE
(Paraburkholderia
xenovorans) 		3 / 3 TYR A 157
GLY A  66
PRO A  67
 None
GSH  A 224 (-3.9A)
None
 0.55A 4qwpA-2gdrA:
undetectable		 4qwpA-2gdrA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_D_SAMD301_1
(UNCHARACTERIZED
PROTEIN)		 5lkd GLUTATHIONE
S-TRANSFERASE
OMEGA-LIKE 2
(Saccharomyces
cerevisiae) 		3 / 3 ARG A  15
GLU A 238
TYR A 216
 GSH  A 401 (-4.0A)
None
None
 1.01A 4r29D-5lkdA:
undetectable		 4r29D-5lkdA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4S0V_A_SUVA2001_2
(HUMAN OREXIN
RECEPTOR TYPE 2
FUSION PROTEIN TO P.
ABYSII GLYCOGEN
SYNTHASE)		 5f06 GLUTATHIONE
S-TRANSFERASE FAMILY
PROTEIN
(Populus
trichocarpa) 		4 / 5 ILE A  54
PRO A  55
HIS A 169
VAL A 208
 GSH  A 301 (-4.2A)
GSH  A 301 ( 4.8A)
None
None
 1.33A 4s0vA-5f06A:
undetectable		 4s0vA-5f06A:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UDC_A_DEXA1778_2
(GLUCOCORTICOID
RECEPTOR)		 1kcg ULBP3 PROTEIN
(Homo
sapiens) 		3 / 3 MET C 179
GLN C  60
TYR C  62
 GSH  C 999 (-4.6A)
None
None
 1.07A 4udcA-1kcgC:
1.8		 4udcA-1kcgC:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UY8_7_TRP71002_0
(TRYPTOPHANASE)		 4nhw GLUTATHIONE
S-TRANSFERASE
(Sinorhizobium
meliloti) 		4 / 4 ILE A  57
ASN A  58
ILE A  63
VAL A  31
 None
None
GSH  A 301 (-4.1A)
None
 1.20A 4uy87-4nhwA:
undetectable		 4uy87-4nhwA:
7.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_K_CHDK103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 4w66 GLUTATHIONE
S-TRANSFERASE DOMAIN
PROTEIN
(Haliangium
ochraceum) 		5 / 11 GLU A 165
LEU A 170
LEU A 182
ARG A 183
LEU A 186
 None
None
GSH  A 301 ( 4.2A)
GSH  A 301 (-4.2A)
None
 1.23A 4wg0I-4w66A:
undetectable
4wg0J-4w66A:
undetectable
4wg0K-4w66A:
undetectable		 4wg0I-4w66A:
4.50
4wg0J-4w66A:
4.50
4wg0K-4w66A:
4.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5G_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4eq9 ABC TRANSPORTER
SUBSTRATE-BINDING
PROTEIN-AMINO ACID
TRANSPORT
(Streptococcus
pneumoniae) 		5 / 12 ASP A  94
LEU A  93
PHE A  90
THR A 108
LEU A 105
 None
None
None
None
GSH  A 301 (-4.7A)
 1.09A 4x5gA-4eq9A:
undetectable		 4x5gA-4eq9A:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YDQ_B_HFGB802_0
(PROLINE--TRNA LIGASE)		 5ft3 GLUTATHIONE
S-TRANSFERASE
EPSILON 2
(Aedes
aegypti) 		5 / 12 VAL A 207
PRO A  13
GLU A 103
HIS A  69
GLY A 105
 None
GSH  A1221 ( 4.2A)
None
GSH  A1221 (-4.4A)
None
 1.45A 4ydqB-5ft3A:
undetectable		 4ydqB-5ft3A:
18.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z2E_F_TR6F101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
SYMMETRIZED E-SITE
DNA)		 1oyj GLUTATHIONE
S-TRANSFERASE
(Oryza
sativa) 		4 / 5 GLY A 119
ARG A 121
GLY A 134
GLU A 136
 None
GSH  A 800 (-3.6A)
None
GSH  A 800 (-3.6A)
 1.15A 4z2eB-1oyjA:
undetectable
4z2eC-1oyjA:
undetectable		 4z2eB-1oyjA:
16.63
4z2eC-1oyjA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZDZ_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3c8e YGHU, GLUTATHIONE
S-TRANSFERASE
HOMOLOGUE
(Escherichia
coli) 		4 / 7 ILE A  82
GLY A  55
THR A  59
LEU A  47
 GSH  A 289 (-3.7A)
None
None
None
 0.92A 4zdzA-3c8eA:
undetectable		 4zdzA-3c8eA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZDZ_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4pua GLUTATHIONE
S-TRANSFERASE
(Streptococcus
pneumoniae) 		4 / 7 ILE A  80
GLY A  53
THR A  57
LEU A  75
 GSH  A 302 ( 3.8A)
None
None
None
 0.77A 4zdzA-4puaA:
undetectable		 4zdzA-4puaA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE3_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3c8e YGHU, GLUTATHIONE
S-TRANSFERASE
HOMOLOGUE
(Escherichia
coli) 		4 / 7 ILE A  82
GLY A  55
THR A  59
LEU A  47
 GSH  A 289 (-3.7A)
None
None
None
 0.92A 4ze3A-3c8eA:
undetectable		 4ze3A-3c8eA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE3_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4pua GLUTATHIONE
S-TRANSFERASE
(Streptococcus
pneumoniae) 		4 / 7 ILE A  80
GLY A  53
THR A  57
LEU A  75
 GSH  A 302 ( 3.8A)
None
None
None
 0.79A 4ze3A-4puaA:
undetectable		 4ze3A-4puaA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZP0_A_DXCA500_0
(MULTIDRUG
TRANSPORTER MDFA)		 4pua GLUTATHIONE
S-TRANSFERASE
(Streptococcus
pneumoniae) 		5 / 10 LEU A  36
PRO A 100
LEU A  93
GLY A  39
GLN A  44
 None
GSH  A 302 ( 4.7A)
None
None
None
 1.43A 4zp0A-4puaA:
0.4		 4zp0A-4puaA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AYA_A_X8ZA307_1
(METALLO-BETA-LACTAMA
SE)		 1qh5 PROTEIN
(HYDROXYACYLGLUTATHI
ONE HYDROLASE)
(Homo
sapiens) 		6 / 11 HIS A  54
HIS A  56
ASP A  58
HIS A  59
HIS A 110
ARG A 249
 ZN  A 261 ( 3.4A)
ZN  A 261 ( 3.3A)
ZN  A 262 (-2.7A)
ZN  A 262 ( 3.3A)
ZN  A 261 (-3.3A)
GSH  A 463 (-2.8A)
 0.78A 5ayaA-1qh5A:
15.7		 5ayaA-1qh5A:
25.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4U_B_SAMB301_0
(UNCHARACTERIZED
PROTEIN MJ0489)		 4z9n AMINO ACID ABC
TRANSPORTER,
PERIPLASMIC AMINO
ACID-BINDING PROTEIN
(Brucella
ovis) 		5 / 12 GLY A 207
TYR A 101
THR A  82
GLY A 104
PHE A  25
 None
None
GSH  A 401 (-4.3A)
None
None
 1.12A 5d4uB-4z9nA:
undetectable		 5d4uB-4z9nA:
20.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5D9W_A_ASCA301_0
(DEHYDROASCORBATE
REDUCTASE)		 5lol GLUTATHIONE
S-TRANSFERASE DHAR2
(Arabidopsis
thaliana) 		5 / 9 PRO A  21
PHE A 103
HIS A 160
GLY A 206
TRP A 207
 GSH  A 301 ( 4.9A)
None
None
None
None
 0.41A 5d9wA-5lolA:
31.4		 5d9wA-5lolA:
68.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DB5_A_CYSA503_0
(CYSTEINE DESULFURASE)		 4wab PROSTAGLANDIN E
SYNTHASE,LEUKOTRIENE
C4 SYNTHASE
(Homo
sapiens) 		4 / 8 HIS A 113
ASN A  74
ARG A  70
ARG A  73
 GSH  A 201 (-4.1A)
GSH  A 201 (-3.7A)
None
GSH  A 201 (-3.7A)
 1.21A 5db5A-4wabA:
undetectable
5db5B-4wabA:
undetectable		 5db5A-4wabA:
21.37
5db5B-4wabA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DB5_A_CYSA503_0
(CYSTEINE DESULFURASE)		 4yl0 PROSTAGLANDIN E
SYNTHASE
(Homo
sapiens) 		4 / 8 HIS A 113
ASN A  74
ARG A  70
ARG A  73
 GSH  A 202 (-4.0A)
GSH  A 202 (-3.6A)
None
GSH  A 202 (-3.3A)
 1.29A 5db5A-4yl0A:
undetectable
5db5B-4yl0A:
undetectable		 5db5A-4yl0A:
17.24
5db5B-4yl0A:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DLW_A_5D5A905_0
(ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 2)		 4hi7 GI20122
(Drosophila
mojavensis) 		5 / 12 LEU A 112
ARG A  16
HIS A  69
VAL A 172
TYR A 139
 None
None
GSH  A 301 (-4.0A)
None
None
 1.16A 5dlwA-4hi7A:
0.6		 5dlwA-4hi7A:
15.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EIF_C_SAMC4000_0
(GENOME POLYPROTEIN)		 4ikh GLUTATHIONE
S-TRANSFERASE
(Pseudomonas
protegens) 		5 / 12 GLY A 134
GLY A 131
ASP A 165
VAL A 211
ILE A 205
 None
GSH  A 303 (-3.3A)
None
None
None
 0.90A 5eifC-4ikhA:
undetectable		 5eifC-4ikhA:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESF_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3c8e YGHU, GLUTATHIONE
S-TRANSFERASE
HOMOLOGUE
(Escherichia
coli) 		4 / 8 ILE A  82
GLY A  55
THR A  59
LEU A  47
 GSH  A 289 (-3.7A)
None
None
None
 0.89A 5esfA-3c8eA:
undetectable		 5esfA-3c8eA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESJ_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3c8e YGHU, GLUTATHIONE
S-TRANSFERASE
HOMOLOGUE
(Escherichia
coli) 		4 / 8 ILE A  82
GLY A  55
THR A  59
LEU A  47
 GSH  A 289 (-3.7A)
None
None
None
 0.88A 5esjA-3c8eA:
undetectable		 5esjA-3c8eA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESJ_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4pua GLUTATHIONE
S-TRANSFERASE
(Streptococcus
pneumoniae) 		4 / 8 ILE A  80
GLY A  53
THR A  57
LEU A  75
 GSH  A 302 ( 3.8A)
None
None
None
 0.80A 5esjA-4puaA:
undetectable		 5esjA-4puaA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESM_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4pua GLUTATHIONE
S-TRANSFERASE
(Streptococcus
pneumoniae) 		4 / 7 ILE A  80
GLY A  53
THR A  57
LEU A  75
 GSH  A 302 ( 3.8A)
None
None
None
 0.75A 5esmA-4puaA:
undetectable		 5esmA-4puaA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FCT_B_C2FB402_0
(THYMIDYLATE SYNTHASE)		 5lkd GLUTATHIONE
S-TRANSFERASE
OMEGA-LIKE 2
(Saccharomyces
cerevisiae) 		5 / 12 VAL A 158
ILE A 177
LEU A 199
LEU A  53
ALA A  57
 GSH  A 401 (-4.0A)
None
None
None
None
 1.33A 5fctB-5lkdA:
undetectable		 5fctB-5lkdA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GLM_A_ACTA613_0
(GLYCOSIDE HYDROLASE
FAMILY 43)		 2pbj PROSTAGLANDIN E
SYNTHASE 2
(Macaca
fascicularis) 		3 / 3 ASP A 240
SER A 166
TYR A 209
 None
GSH  A 477 ( 4.6A)
None
 0.88A 5glmA-2pbjA:
undetectable		 5glmA-2pbjA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_C_P06C801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 1f2e GLUTATHIONE
S-TRANSFERASE
(Sphingomonas
paucimobilis) 		4 / 7 ILE A   5
VAL A 168
ASN A  66
PHE A 109
 None
None
GSH  A 210 (-4.1A)
None
 0.93A 5hieC-1f2eA:
0.0		 5hieC-1f2eA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HS1_A_VORA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3c8e YGHU, GLUTATHIONE
S-TRANSFERASE
HOMOLOGUE
(Escherichia
coli) 		4 / 8 ILE A  82
GLY A  55
THR A  59
LEU A  47
 GSH  A 289 (-3.7A)
None
None
None
 0.81A 5hs1A-3c8eA:
2.2		 5hs1A-3c8eA:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HS1_A_VORA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4pua GLUTATHIONE
S-TRANSFERASE
(Streptococcus
pneumoniae) 		4 / 8 ILE A  80
GLY A  53
THR A  57
LEU A  45
 GSH  A 302 ( 3.8A)
None
None
None
 0.87A 5hs1A-4puaA:
undetectable		 5hs1A-4puaA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HS1_A_VORA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4pua GLUTATHIONE
S-TRANSFERASE
(Streptococcus
pneumoniae) 		4 / 8 ILE A  80
GLY A  53
THR A  57
LEU A  75
 GSH  A 302 ( 3.8A)
None
None
None
 0.64A 5hs1A-4puaA:
undetectable		 5hs1A-4puaA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGI_A_ZITA402_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 5f05 PHI CLASS
GLUTATHIONE
TRANSFERASE GSTF5
(Populus
trichocarpa) 		4 / 6 PRO A  56
HIS A 168
ALA A 203
TYR A  79
 GSH  A 301 ( 4.6A)
None
None
None
 1.00A 5igiA-5f05A:
undetectable		 5igiA-5f05A:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IH0_A_ACTA402_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 3vpq GLUTATHIONE
S-TRANSFERASE SIGMA
(Bombyx
mori) 		4 / 6 PHE A   9
PRO A  10
ARG A  19
ILE A  34
 GSH  A 301 (-4.3A)
None
None
None
 1.39A 5ih0A-3vpqA:
undetectable		 5ih0A-3vpqA:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IH0_A_ACTA402_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 5d73 GLUTATHIONE
S-TRANSFERASE
(Wuchereria
bancrofti) 		4 / 6 PHE A   8
PRO A   9
ARG A  18
ILE A  33
 GSH  A 301 (-4.9A)
None
None
None
 1.39A 5ih0A-5d73A:
undetectable		 5ih0A-5d73A:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IH0_A_ACTA402_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 5d73 GLUTATHIONE
S-TRANSFERASE
(Wuchereria
bancrofti) 		4 / 6 PHE A   8
PRO A   9
THR A   6
ILE A  33
 GSH  A 301 (-4.9A)
None
None
None
 1.30A 5ih0A-5d73A:
undetectable		 5ih0A-5d73A:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKM_A_SAMA311_0
(NS5 METHYL
TRANSFERASE)		 4ikh GLUTATHIONE
S-TRANSFERASE
(Pseudomonas
protegens) 		5 / 12 GLY A 134
GLY A 131
ASP A 165
VAL A 211
ILE A 205
 None
GSH  A 303 (-3.3A)
None
None
None
 0.90A 5ikmA-4ikhA:
undetectable		 5ikmA-4ikhA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_B_RCXB601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1tu7 GLUTATHIONE
S-TRANSFERASE 2
(Onchocerca
volvulus) 		4 / 4 LEU A  50
ARG A  32
ILE A  33
PHE A   8
 GSH  A1001 (-4.5A)
None
None
GSH  A1001 (-4.8A)
 1.31A 5kirB-1tu7A:
0.0		 5kirB-1tu7A:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KKZ_E_ASCE1004_0
(CYTOCHROME B
UBIQUINOL-CYTOCHROME
C REDUCTASE
IRON-SULFUR SUBUNIT)		 4g10 GLUTATHIONE
S-TRANSFERASE
HOMOLOG
(Sphingomonas
paucimobilis) 		4 / 7 HIS A  11
ILE A  12
TYR A 214
ARG A 170
 None
GSH  A 300 (-3.3A)
ACT  A 301 (-4.5A)
None
 1.25A 5kkzC-4g10A:
undetectable
5kkzE-4g10A:
undetectable		 5kkzC-4g10A:
20.15
5kkzE-4g10A:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KKZ_K_ASCK1004_0
(CYTOCHROME B
UBIQUINOL-CYTOCHROME
C REDUCTASE
IRON-SULFUR SUBUNIT)		 4g10 GLUTATHIONE
S-TRANSFERASE
HOMOLOG
(Sphingomonas
paucimobilis) 		4 / 7 HIS A  11
ILE A  12
TYR A 214
ARG A 170
 None
GSH  A 300 (-3.3A)
ACT  A 301 (-4.5A)
None
 1.25A 5kkzK-4g10A:
undetectable
5kkzQ-4g10A:
undetectable		 5kkzK-4g10A:
20.66
5kkzQ-4g10A:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KKZ_O_ASCO1004_0
(CYTOCHROME B
UBIQUINOL-CYTOCHROME
C REDUCTASE
IRON-SULFUR SUBUNIT)		 4g10 GLUTATHIONE
S-TRANSFERASE
HOMOLOG
(Sphingomonas
paucimobilis) 		4 / 7 HIS A  11
ILE A  12
TYR A 214
ARG A 170
 None
GSH  A 300 (-3.3A)
ACT  A 301 (-4.5A)
None
 1.24A 5kkzM-4g10A:
undetectable
5kkzO-4g10A:
undetectable		 5kkzM-4g10A:
20.15
5kkzO-4g10A:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KMD_C_6UBC1304_1
(ION TRANSPORT
PROTEIN)		 3c8e YGHU, GLUTATHIONE
S-TRANSFERASE
HOMOLOGUE
(Escherichia
coli) 		4 / 5 TYR A 167
LEU A 157
GLY A 158
PHE A 161
 None
None
GSH  A 290 (-3.4A)
None
 0.93A 5kmdC-3c8eA:
2.4
5kmdD-3c8eA:
2.5		 5kmdC-3c8eA:
22.57
5kmdD-3c8eA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KQR_A_SAMA301_0
(METHYLTRANSFERASE)		 4ikh GLUTATHIONE
S-TRANSFERASE
(Pseudomonas
protegens) 		5 / 12 GLY A 134
GLY A 131
ASP A 165
VAL A 211
ILE A 205
 None
GSH  A 303 (-3.3A)
None
None
None
 0.90A 5kqrA-4ikhA:
undetectable		 5kqrA-4ikhA:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KQS_A_SAMA307_0
(GENOME POLYPROTEIN)		 4ikh GLUTATHIONE
S-TRANSFERASE
(Pseudomonas
protegens) 		5 / 12 GLY A 134
GLY A 131
ASP A 165
VAL A 211
ILE A 205
 None
GSH  A 303 (-3.3A)
None
None
None
 0.89A 5kqsA-4ikhA:
undetectable		 5kqsA-4ikhA:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJB_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 1)		 1oyj GLUTATHIONE
S-TRANSFERASE
(Oryza
sativa) 		5 / 12 SER A  15
PHE A  17
ARG A  20
MET A  25
ILE A  72
 GSH  A 799 (-3.3A)
GSH  A 799 (-4.0A)
None
None
None
 1.29A 5ljbA-1oyjA:
undetectable		 5ljbA-1oyjA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJB_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 1)		 4g19 GLUTATHIONE
TRANSFERASE GTE1
(Phanerochaete
chrysosporium) 		5 / 12 LEU A 118
ALA A  89
PRO A  74
TYR A  30
ILE A 207
 None
None
GSH  A 302 (-4.4A)
None
None
 1.36A 5ljbA-4g19A:
undetectable		 5ljbA-4g19A:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M50_B_TA1B502_1
(TUBULIN BETA-2B
CHAIN)		 1tu7 GLUTATHIONE
S-TRANSFERASE 2
(Onchocerca
volvulus) 		5 / 12 ASP A  30
PRO A  16
ARG A  18
GLY A  12
LEU A  13
 None
None
None
None
GSH  A1001 (-4.4A)
 1.42A 5m50B-1tu7A:
undetectable		 5m50B-1tu7A:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M50_B_TA1B502_1
(TUBULIN BETA-2B
CHAIN)		 5h5l GLUTATHIONE
S-TRANSFERASE S2
(Nilaparvata
lugens) 		5 / 12 ASP A  31
PRO A  17
ARG A  19
GLY A  13
LEU A  14
 None
None
None
PEG  A 302 (-3.5A)
GSH  A 301 (-4.2A)
 1.24A 5m50B-5h5lA:
undetectable		 5m50B-5h5lA:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5B_A_SAMA1001_0
(NS5
METHYLTRANSFERASE)		 4ikh GLUTATHIONE
S-TRANSFERASE
(Pseudomonas
protegens) 		5 / 12 GLY A 134
GLY A 131
ASP A 165
VAL A 211
ILE A 205
 None
GSH  A 303 (-3.3A)
None
None
None
 0.92A 5m5bA-4ikhA:
undetectable		 5m5bA-4ikhA:
23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5K_B_ADNB502_2
(ADENOSYLHOMOCYSTEINA
SE)		 3ibh SACCHAROMYCES
CEREVISIAE GTT2
(Saccharomyces
cerevisiae) 		4 / 4 GLN A 147
THR A 136
LEU A  53
LEU A 139
 None
None
GSH  A 234 ( 4.6A)
None
 1.11A 5m5kB-3ibhA:
undetectable		 5m5kB-3ibhA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NCD_A_ACTA301_0
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 4ysl BETA-LACTAMASE
DOMAIN PROTEIN
(Pseudomonas
putida) 		5 / 6 ASP A 170
HIS A 149
HIS A  74
HIS A 212
HIS A  79
 FE  A 301 ( 3.1A)
FE  A 301 ( 3.5A)
FE  A 301 (-3.4A)
GSH  A 302 ( 4.8A)
None
 1.29A 5ncdA-4yslA:
undetectable
5ncdD-4yslA:
undetectable		 5ncdA-4yslA:
21.97
5ncdD-4yslA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NCD_C_ACTC301_0
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 4ysl BETA-LACTAMASE
DOMAIN PROTEIN
(Pseudomonas
putida) 		5 / 6 HIS A  79
ASP A 170
HIS A 149
HIS A  74
HIS A 212
 None
FE  A 301 ( 3.1A)
FE  A 301 ( 3.5A)
FE  A 301 (-3.4A)
GSH  A 302 ( 4.8A)
 1.28A 5ncdB-4yslA:
undetectable
5ncdC-4yslA:
undetectable		 5ncdB-4yslA:
21.97
5ncdC-4yslA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NJV_A_SAMA301_0
(NS5)		 4ikh GLUTATHIONE
S-TRANSFERASE
(Pseudomonas
protegens) 		5 / 12 GLY A 134
GLY A 131
ASP A 165
VAL A 211
ILE A 205
 None
GSH  A 303 (-3.3A)
None
None
None
 0.88A 5njvA-4ikhA:
undetectable		 5njvA-4ikhA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NJV_B_SAMB301_0
(NS5)		 4ikh GLUTATHIONE
S-TRANSFERASE
(Pseudomonas
protegens) 		5 / 12 GLY A 134
GLY A 131
ASP A 165
VAL A 211
ILE A 205
 None
GSH  A 303 (-3.3A)
None
None
None
 0.86A 5njvB-4ikhA:
undetectable		 5njvB-4ikhA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_A_CUA601_0
(THIOCYANATE
DEHYDROGENASE)		 4ysl BETA-LACTAMASE
DOMAIN PROTEIN
(Pseudomonas
putida) 		3 / 3 HIS A 212
ASP A  78
HIS A  79
 GSH  A 302 ( 4.8A)
GSH  A 302 ( 4.4A)
None
 0.78A 5oexA-4yslA:
undetectable		 5oexA-4yslA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_A_CUA602_0
(THIOCYANATE
DEHYDROGENASE)		 3e73 LANC-LIKE PROTEIN 1
(Homo
sapiens) 		3 / 3 LYS A 317
HIS A 274
HIS A 323
 GSH  A 502 (-2.7A)
GSH  A 502 (-4.0A)
ZN  A 501 ( 3.0A)
 1.29A 5oexA-3e73A:
undetectable		 5oexA-3e73A:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_B_CUB601_0
(THIOCYANATE
DEHYDROGENASE)		 4ysl BETA-LACTAMASE
DOMAIN PROTEIN
(Pseudomonas
putida) 		3 / 3 HIS A 212
ASP A  78
HIS A  79
 GSH  A 302 ( 4.8A)
GSH  A 302 ( 4.4A)
None
 0.77A 5oexB-4yslA:
undetectable		 5oexB-4yslA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_B_CUB602_0
(THIOCYANATE
DEHYDROGENASE)		 3e73 LANC-LIKE PROTEIN 1
(Homo
sapiens) 		3 / 3 LYS A 317
HIS A 274
HIS A 323
 GSH  A 502 (-2.7A)
GSH  A 502 (-4.0A)
ZN  A 501 ( 3.0A)
 1.30A 5oexB-3e73A:
undetectable		 5oexB-3e73A:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_C_CUC601_0
(THIOCYANATE
DEHYDROGENASE)		 4ysl BETA-LACTAMASE
DOMAIN PROTEIN
(Pseudomonas
putida) 		3 / 3 HIS A 212
ASP A  78
HIS A  79
 GSH  A 302 ( 4.8A)
GSH  A 302 ( 4.4A)
None
 0.75A 5oexC-4yslA:
undetectable		 5oexC-4yslA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_C_CUC603_0
(THIOCYANATE
DEHYDROGENASE)		 3e73 LANC-LIKE PROTEIN 1
(Homo
sapiens) 		3 / 3 LYS A 317
HIS A 274
HIS A 323
 GSH  A 502 (-2.7A)
GSH  A 502 (-4.0A)
ZN  A 501 ( 3.0A)
 1.28A 5oexC-3e73A:
undetectable		 5oexC-3e73A:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_D_CUD601_0
(THIOCYANATE
DEHYDROGENASE)		 4ysl BETA-LACTAMASE
DOMAIN PROTEIN
(Pseudomonas
putida) 		3 / 3 HIS A 212
ASP A  78
HIS A  79
 GSH  A 302 ( 4.8A)
GSH  A 302 ( 4.4A)
None
 0.72A 5oexD-4yslA:
undetectable		 5oexD-4yslA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_D_CUD603_0
(THIOCYANATE
DEHYDROGENASE)		 3e73 LANC-LIKE PROTEIN 1
(Homo
sapiens) 		3 / 3 LYS A 317
HIS A 274
HIS A 323
 GSH  A 502 (-2.7A)
GSH  A 502 (-4.0A)
ZN  A 501 ( 3.0A)
 1.27A 5oexD-3e73A:
undetectable		 5oexD-3e73A:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TIW_B_OAQB302_0
(SULFOTRANSFERASE)		 1r4w GLUTATHIONE
S-TRANSFERASE,
MITOCHONDRIAL
(Rattus
norvegicus) 		5 / 12 ILE A 125
ASP A  13
LEU A  44
ILE A  70
PHE A  87
 None
None
GSH  A 301 ( 4.9A)
None
None
 1.29A 5tiwB-1r4wA:
1.8		 5tiwB-1r4wA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U63_A_ACTA405_0
(THIOREDOXIN
REDUCTASE)		 3e73 LANC-LIKE PROTEIN 1
(Homo
sapiens) 		3 / 3 GLY A 324
LEU A 315
HIS A 274
 None
None
GSH  A 502 (-4.0A)
 0.70A 5u63A-3e73A:
undetectable		 5u63A-3e73A:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UIG_A_EDTA501_0
(ADENOSINE RECEPTOR
A2A,SOLUBLE
CYTOCHROME
B562,ADENOSINE
RECEPTOR A2A)		 4z9n AMINO ACID ABC
TRANSPORTER,
PERIPLASMIC AMINO
ACID-BINDING PROTEIN
(Brucella
ovis) 		4 / 6 ASN A  81
ASN A  19
ARG A  66
ILE A 159
 GSH  A 401 (-3.3A)
GSH  A 401 (-3.2A)
GSH  A 401 (-3.1A)
GSH  A 401 (-3.6A)
 0.96A 5uigA-4z9nA:
undetectable		 5uigA-4z9nA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA312_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 1b4q PROTEIN (HUMAN
THIOLTRANSFERASE)
(Homo
sapiens) 		3 / 3 ILE A  79
VAL A  72
PRO A  70
 None
None
GSH  A 106 ( 4.3A)
 0.59A 5uunA-1b4qA:
5.8		 5uunA-1b4qA:
17.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5UUN_B_ACTB308_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 3c8e YGHU, GLUTATHIONE
S-TRANSFERASE
HOMOLOGUE
(Escherichia
coli) 		3 / 3 LEU A  50
ILE A  82
TYR A 167
 None
GSH  A 289 (-3.7A)
None
 0.31A 5uunB-3c8eA:
39.3		 5uunB-3c8eA:
59.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5UUN_B_ACTB308_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 4pua GLUTATHIONE
S-TRANSFERASE
(Streptococcus
pneumoniae) 		3 / 3 LEU A  48
ILE A  80
TYR A 165
 None
GSH  A 302 ( 3.8A)
None
 0.35A 5uunB-4puaA:
36.0		 5uunB-4puaA:
49.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5UUN_B_ACTB311_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 3c8e YGHU, GLUTATHIONE
S-TRANSFERASE
HOMOLOGUE
(Escherichia
coli) 		4 / 4 PHE A  22
PRO A  53
TYR A 167
TYR A 225
 GSH  A 290 ( 3.9A)
None
None
None
 0.42A 5uunB-3c8eA:
39.3		 5uunB-3c8eA:
59.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5UUN_B_ACTB311_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 4pua GLUTATHIONE
S-TRANSFERASE
(Streptococcus
pneumoniae) 		4 / 4 PHE A  20
PRO A  51
TYR A 165
TYR A 223
 GSH  A 301 (-3.4A)
None
None
None
 0.67A 5uunB-4puaA:
36.0		 5uunB-4puaA:
49.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_B_ACTB311_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 5uuo GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN
(Novosphingobium
aromaticivorans) 		4 / 4 PHE B  26
PRO B  57
TYR B 171
TYR B 229
 GSH  B 302 (-2.8A)
None
EDO  B 313 (-3.4A)
EDO  B 313 (-4.7A)
 0.33A 5uunB-5uuoB:
46.9		 5uunB-5uuoB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_C_CVIC301_1
(REGULATORY PROTEIN
TETR)		 5f07 PUTATIVE GLUTATHIONE
S-TRANSFERASE FAMILY
PROTEIN
(Populus
trichocarpa) 		4 / 7 GLY A 125
ILE A 120
GLN A  40
ASP A  36
 None
None
GSH  A 301 (-3.8A)
None
 1.13A 5vlmC-5f07A:
undetectable		 5vlmC-5f07A:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_F_CVIF301_1
(REGULATORY PROTEIN
TETR)		 4ofn GLUTATHIONE
S-TRANSFERASE-1
(Necator
americanus) 		4 / 8 ILE A  11
TYR A 107
VAL A  51
ASP A  31
 None
None
GSH  A 301 (-4.5A)
None
 1.16A 5vlmF-4ofnA:
undetectable		 5vlmF-4ofnA:
24.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WWS_B_SAMB501_0
(PUTATIVE
METHYLTRANSFERASE
NSUN6)		 3c8e YGHU, GLUTATHIONE
S-TRANSFERASE
HOMOLOGUE
(Escherichia
coli) 		5 / 12 ALA A 168
PRO A 169
GLY A  20
LYS A 171
GLY A 158
 None
None
None
None
GSH  A 290 (-3.4A)
 1.26A 5wwsB-3c8eA:
undetectable		 5wwsB-3c8eA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WYQ_B_SAMB301_0
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 4ikh GLUTATHIONE
S-TRANSFERASE
(Pseudomonas
protegens) 		5 / 12 TYR A 197
LEU A 193
GLY A 131
ILE A 190
GLY A 127
 None
None
GSH  A 303 (-3.3A)
None
GSH  A 303 (-3.8A)
 0.81A 5wyqB-4ikhA:
undetectable		 5wyqB-4ikhA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ1_A_SAMA601_0
(NS5
METHYLTRANSFERASE)		 4ikh GLUTATHIONE
S-TRANSFERASE
(Pseudomonas
protegens) 		5 / 12 GLY A 134
GLY A 131
ASP A 165
VAL A 211
ILE A 205
 None
GSH  A 303 (-3.3A)
None
None
None
 0.87A 5wz1A-4ikhA:
undetectable		 5wz1A-4ikhA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ1_B_SAMB601_0
(NS5
METHYLTRANSFERASE)		 4ikh GLUTATHIONE
S-TRANSFERASE
(Pseudomonas
protegens) 		5 / 12 GLY A 134
GLY A 131
ASP A 165
VAL A 211
ILE A 205
 None
GSH  A 303 (-3.3A)
None
None
None
 0.87A 5wz1B-4ikhA:
undetectable		 5wz1B-4ikhA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ1_C_SAMC601_0
(NS5
METHYLTRANSFERASE)		 4ikh GLUTATHIONE
S-TRANSFERASE
(Pseudomonas
protegens) 		5 / 12 GLY A 134
GLY A 131
ASP A 165
VAL A 211
ILE A 205
 None
GSH  A 303 (-3.3A)
None
None
None
 0.86A 5wz1C-4ikhA:
undetectable		 5wz1C-4ikhA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ1_D_SAMD601_0
(NS5
METHYLTRANSFERASE)		 4ikh GLUTATHIONE
S-TRANSFERASE
(Pseudomonas
protegens) 		5 / 12 GLY A 134
GLY A 131
ASP A 165
VAL A 211
ILE A 205
 None
GSH  A 303 (-3.3A)
None
None
None
 0.84A 5wz1D-4ikhA:
undetectable		 5wz1D-4ikhA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ1_E_SAME601_0
(NS5
METHYLTRANSFERASE)		 4ikh GLUTATHIONE
S-TRANSFERASE
(Pseudomonas
protegens) 		5 / 12 GLY A 134
GLY A 131
ASP A 165
VAL A 211
ILE A 205
 None
GSH  A 303 (-3.3A)
None
None
None
 0.87A 5wz1E-4ikhA:
undetectable		 5wz1E-4ikhA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ1_F_SAMF601_0
(NS5
METHYLTRANSFERASE)		 4ikh GLUTATHIONE
S-TRANSFERASE
(Pseudomonas
protegens) 		5 / 12 GLY A 134
GLY A 131
ASP A 165
VAL A 211
ILE A 205
 None
GSH  A 303 (-3.3A)
None
None
None
 0.85A 5wz1F-4ikhA:
undetectable		 5wz1F-4ikhA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ1_G_SAMG601_0
(NS5
METHYLTRANSFERASE)		 4ikh GLUTATHIONE
S-TRANSFERASE
(Pseudomonas
protegens) 		5 / 12 GLY A 134
GLY A 131
ASP A 165
VAL A 211
ILE A 205
 None
GSH  A 303 (-3.3A)
None
None
None
 0.88A 5wz1G-4ikhA:
undetectable		 5wz1G-4ikhA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ1_H_SAMH601_0
(NS5
METHYLTRANSFERASE)		 4ikh GLUTATHIONE
S-TRANSFERASE
(Pseudomonas
protegens) 		5 / 12 GLY A 134
GLY A 131
ASP A 165
VAL A 211
ILE A 205
 None
GSH  A 303 (-3.3A)
None
None
None
 0.85A 5wz1H-4ikhA:
undetectable		 5wz1H-4ikhA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIO_A_HFGA801_0
(PROLINE-TRNA
SYNTHETASE CLASS II
AARS (YBAK RNA
BINDING DOMAIN PLUS
TRNA SYNTHETASE))		 5ft3 GLUTATHIONE
S-TRANSFERASE
EPSILON 2
(Aedes
aegypti) 		5 / 12 VAL A 207
PRO A  13
GLU A 103
HIS A  69
GLY A 105
 None
GSH  A1221 ( 4.2A)
None
GSH  A1221 (-4.4A)
None
 1.42A 5xioA-5ft3A:
undetectable		 5xioA-5ft3A:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_B_CHDB401_0
(BILE SALT HYDROLASE)		 4pyr PUTATIVE
BRANCHED-CHAIN AMINO
ACID ABC TRANSPORTER
(Chromobacterium
violaceum) 		5 / 10 LEU A  90
ILE A 154
LEU A 342
ALA A 339
LEU A 335
 None
None
None
None
GSH  A 401 (-4.8A)
 1.20A 5y7pB-4pyrA:
undetectable		 5y7pB-4pyrA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_D_CHDD401_0
(BILE SALT HYDROLASE)		 4pyr PUTATIVE
BRANCHED-CHAIN AMINO
ACID ABC TRANSPORTER
(Chromobacterium
violaceum) 		5 / 10 LEU A  90
ILE A 154
LEU A 342
ALA A 339
LEU A 335
 None
None
None
None
GSH  A 401 (-4.8A)
 1.14A 5y7pD-4pyrA:
undetectable		 5y7pD-4pyrA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_G_CHDG401_0
(BILE SALT HYDROLASE)		 4pyr PUTATIVE
BRANCHED-CHAIN AMINO
ACID ABC TRANSPORTER
(Chromobacterium
violaceum) 		5 / 10 LEU A  90
ILE A 154
LEU A 342
ALA A 339
LEU A 335
 None
None
None
None
GSH  A 401 (-4.8A)
 1.15A 5y7pG-4pyrA:
undetectable		 5y7pG-4pyrA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_H_CHDH401_0
(BILE SALT HYDROLASE)		 4pyr PUTATIVE
BRANCHED-CHAIN AMINO
ACID ABC TRANSPORTER
(Chromobacterium
violaceum) 		5 / 10 LEU A  90
ILE A 154
LEU A 342
ALA A 339
LEU A 335
 None
None
None
None
GSH  A 401 (-4.8A)
 1.20A 5y7pH-4pyrA:
undetectable		 5y7pH-4pyrA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YW0_A_ACTA409_0
(UNCHARACTERIZED
PROTEIN KDOO)		 5n9u DEHYDROASCORBATE
REDUCTASE FAMILY
PROTEIN
(Populus
trichocarpa) 		3 / 3 ASP A  72
PHE A 103
ARG A  25
 GSH  A 301 (-1.7A)
None
GSH  A 301 ( 4.7A)
 1.12A 5yw0A-5n9uA:
undetectable		 5yw0A-5n9uA:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YW0_A_ACTA412_0
(UNCHARACTERIZED
PROTEIN KDOO)		 4eq9 ABC TRANSPORTER
SUBSTRATE-BINDING
PROTEIN-AMINO ACID
TRANSPORT
(Streptococcus
pneumoniae) 		3 / 3 LYS A  83
ASN A  45
SER A  47
 None
GSH  A 301 (-3.3A)
None
 1.28A 5yw0A-4eq9A:
undetectable		 5yw0A-4eq9A:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6F_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3w8s GLUTATHIONE
S-TRANSFERASE-3
(Necator
americanus) 		5 / 12 ILE A  67
ALA A  62
LEU A  51
ILE A  32
ARG A  19
 None
None
GSH  A 301 (-4.5A)
None
None
 1.23A 5z6fA-3w8sA:
undetectable		 5z6fA-3w8sA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6L_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3w8s GLUTATHIONE
S-TRANSFERASE-3
(Necator
americanus) 		5 / 9 ILE A  67
ALA A  62
LEU A  51
ILE A  32
ARG A  19
 None
None
GSH  A 301 (-4.5A)
None
None
 1.29A 5z6lA-3w8sA:
undetectable		 5z6lA-3w8sA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A4I_A_TRPA403_0
(TRYPTOPHAN
2,3-DIOXYGENASE)		 3cru GLUTATHIONE
S-TRANSFERASE
CLASS-MU 26 KDA
ISOZYME
(Schistosoma
japonicum) 		4 / 8 THR A  17
PRO A  16
ILE A  71
PRO A  56
 None
None
None
GSH  A 215 (-4.4A)
 1.03A 6a4iA-3cruA:
undetectable		 6a4iA-3cruA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A4I_A_TRPA403_0
(TRYPTOPHAN
2,3-DIOXYGENASE)		 4wr4 GLUTATHIONE
S-TRANSFERASE
CLASS-MU 26 KDA
ISOZYME
(Schistosoma
japonicum) 		4 / 8 THR A  16
PRO A  15
ILE A  70
PRO A  55
 None
None
BYR  A  57 ( 3.8A)
GSH  A 301 (-4.5A)
 1.02A 6a4iA-4wr4A:
2.1		 6a4iA-4wr4A:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A7P_A_9SCA601_1
(SERUM ALBUMIN)		 1m0u GST2 GENE PRODUCT
(Drosophila
melanogaster) 		4 / 5 TYR A 201
VAL A 200
LEU A  67
SER A 110
 None
None
None
GSH  A 500 (-2.5A)
 1.23A 6a7pA-1m0uA:
3.1		 6a7pA-1m0uA:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AGG_Z_AG2Z503_0
(TRNA(ILE2)
2-AGMATINYLCYTIDINE
SYNTHETASE TIAS)		 2gdr GLUTATHIONE
S-TRANSFERASE
(Paraburkholderia
xenovorans) 		4 / 5 GLU A  65
ASN A  47
VAL A  52
CYH A  54
 GSH  A 224 (-3.1A)
None
GSH  A 224 (-4.1A)
None
 1.40A 6aggZ-2gdrA:
0.0		 6aggZ-2gdrA:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_A_NOVA403_2
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		 3vwx GLUTATHIONE
S-TRANSFERASE 6B
(Musca
domestica) 		4 / 6 ARG A 113
LEU A 112
ALA A 173
GLN A 109
 GSH  A 500 (-2.9A)
None
None
None
 0.98A 6b89B-3vwxA:
undetectable		 6b89B-3vwxA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BM5_A_SAMA1301_0
(METHIONINE SYNTHASE)		 3ein GLUTATHIONE
S-TRANSFERASE 1-1
(Drosophila
melanogaster) 		5 / 11 ASP A 101
ARG A  67
TYR A 114
PRO A 115
TYR A 113
 None
GSH  A 210 (-3.6A)
None
None
None
 1.42A 6bm5A-3einA:
undetectable		 6bm5A-3einA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BM5_A_SAMA1301_0
(METHIONINE SYNTHASE)		 5zwp GLUTATHIONE
S-TRANSFERASE 1
(Musca
domestica) 		5 / 11 ASP A 100
ARG A  66
TYR A 113
PRO A 114
TYR A 112
 None
GSH  A 301 (-3.4A)
FMT  A 302 (-4.4A)
None
None
 1.45A 6bm5A-5zwpA:
undetectable		 6bm5A-5zwpA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BP4_A_SAMA505_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC)		 5fhi GLUTATHIONE
S-TRANSFERASE,
PUTATIVE
(Aspergillus
fumigatus) 		3 / 3 ILE A  67
ASN A  99
CYH A 160
 None
GSH  A 301 (-3.2A)
None
 0.83A 6bp4A-5fhiA:
undetectable		 6bp4A-5fhiA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FHW_A_ACRA801_2
(GLUCOAMYLASE P)		 3w8s GLUTATHIONE
S-TRANSFERASE-3
(Necator
americanus) 		3 / 3 TRP A  39
GLU A  38
GLU A  45
 GSH  A 301 (-3.9A)
GOL  A 303 ( 4.7A)
None
 0.75A 6fhwA-3w8sA:
undetectable		 6fhwA-3w8sA:
15.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G9B_B_IXXB705_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN
ENVELOPE
GLYCOPROTEIN)		 5h5l GLUTATHIONE
S-TRANSFERASE S2
(Nilaparvata
lugens) 		4 / 5 ARG A  69
ALA A  68
TYR A 155
GLN A  63
 None
None
None
GSH  A 301 (-3.1A)
 1.34A 6g9bA-5h5lA:
undetectable
6g9bB-5h5lA:
undetectable		 6g9bA-5h5lA:
18.50
6g9bB-5h5lA:
18.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6JI6_A_ACTA305_0
(GLUTATHIONE
S-TRANSFERASE
CLASS-MU 26 KDA
ISOZYME)		 2fhe GLUTATHIONE
S-TRANSFERASE
(Fasciola
hepatica) 		4 / 5 GLY A  11
LEU A  12
SER A 106
TYR A 110
 None
GSH  A 233 (-4.5A)
None
None
 0.68A 6ji6A-2fheA:
33.9		 6ji6A-2fheA:
59.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6JI6_A_ACTA305_0
(GLUTATHIONE
S-TRANSFERASE
CLASS-MU 26 KDA
ISOZYME)		 3cru GLUTATHIONE
S-TRANSFERASE
CLASS-MU 26 KDA
ISOZYME
(Schistosoma
japonicum) 		5 / 5 GLY A  12
LEU A  13
SER A 107
TYR A 111
GLN A 204
 None
GSH  A 215 (-4.5A)
None
None
None
 0.24A 6ji6A-3cruA:
36.6		 6ji6A-3cruA:
99.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6JI6_A_ACTA305_0
(GLUTATHIONE
S-TRANSFERASE
CLASS-MU 26 KDA
ISOZYME)		 4l5o PUTATIVE GLUTATHIONE
TRANSFERASE
(Clonorchis
sinensis) 		4 / 5 GLY A  12
LEU A  13
SER A 107
TYR A 111
 None
GSH  A 301 (-4.4A)
None
None
 0.27A 6ji6A-4l5oA:
33.7		 6ji6A-4l5oA:
59.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6JI6_A_ACTA305_0
(GLUTATHIONE
S-TRANSFERASE
CLASS-MU 26 KDA
ISOZYME)		 4wr4 GLUTATHIONE
S-TRANSFERASE
CLASS-MU 26 KDA
ISOZYME
(Schistosoma
japonicum) 		5 / 5 GLY A  11
LEU A  12
SER A 106
TYR A 110
GLN A 203
 None
GSH  A 301 (-4.1A)
None
None
None
 0.30A 6ji6A-4wr4A:
34.8		 6ji6A-4wr4A:
87.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MA6_A_MYTA603_0
(CYTOCHROME P450 3A4)		 1u3i GLUTATHIONE
S-TRANSFERASE 28 KDA
(Schistosoma
mansoni) 		4 / 6 ARG A  16
ALA A  75
THR A  23
ALA A 165
 GSH  A 301 (-4.2A)
None
None
None
 1.14A 6ma6A-1u3iA:
0.0		 6ma6A-1u3iA:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NKN_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4ags THIOL-DEPENDENT
REDUCTASE 1
(Leishmania
infantum) 		3 / 3 ARG A 431
PHE A 242
PHE A 430
 None
GSH  A1449 (-3.5A)
None
 1.04A 6nknC-4agsA:
undetectable
6nknJ-4agsA:
undetectable		 6nknC-4agsA:
20.27
6nknJ-4agsA:
8.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NKN_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4ysl BETA-LACTAMASE
DOMAIN PROTEIN
(Pseudomonas
putida) 		3 / 3 ARG A 250
PHE A 184
PHE A 173
 GSH  A 302 (-3.3A)
None
GSH  A 302 ( 4.9A)
 1.01A 6nknC-4yslA:
undetectable
6nknJ-4yslA:
undetectable		 6nknC-4yslA:
20.31
6nknJ-4yslA:
12.01