SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'GRF'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G0V_A_MIXA1301_1
(DNA TOPOISOMERASE
2-BETA)		 1zly PHOSPHORIBOSYLGLYCIN
AMIDE
FORMYLTRANSFERASE
(Homo
sapiens) 		4 / 7 ILE A 107
ASN A  13
GLU A 173
GLN A 123
 GRF  A1300 (-4.5A)
GRF  A1300 (-4.0A)
GRF  A1300 (-2.8A)
None
 1.12A 4g0vA-1zlyA:
2.7		 4g0vA-1zlyA:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECN_A_LEUA602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 1zly PHOSPHORIBOSYLGLYCIN
AMIDE
FORMYLTRANSFERASE
(Homo
sapiens) 		4 / 7 ALA A 120
VAL A 169
GLU A 173
HIS A 108
 None
None
GRF  A1300 (-2.8A)
None
 1.06A 5ecnA-1zlyA:
undetectable		 5ecnA-1zlyA:
16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGI_A_ZITA402_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 1zly PHOSPHORIBOSYLGLYCIN
AMIDE
FORMYLTRANSFERASE
(Homo
sapiens) 		5 / 12 ILE A 107
ALA A  28
VAL A   3
GLY A 187
THR A 188
 GRF  A1300 (-4.5A)
None
None
None
None
 1.20A 5igiA-1zlyA:
undetectable		 5igiA-1zlyA:
23.28