SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'GRA'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AQI_A_CHDA2_0
(FERROCHELATASE)		 3mpi GLUTARYL-COA
DEHYDROGENASE
(Desulfococcus
multivorans) 		4 / 6 MET A  73
ARG A 246
GLY A  96
MET A  92
 None
GRA  A 402 (-3.4A)
None
FAD  A 400 ( 4.5A)
 1.48A 3aqiA-3mpiA:
undetectable		 3aqiA-3mpiA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AQI_B_CHDB4_0
(FERROCHELATASE)		 3mpi GLUTARYL-COA
DEHYDROGENASE
(Desulfococcus
multivorans) 		4 / 6 MET A  73
ARG A 246
GLY A  96
MET A  92
 None
GRA  A 402 (-3.4A)
None
FAD  A 400 ( 4.5A)
 1.47A 3aqiB-3mpiA:
undetectable		 3aqiB-3mpiA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JZJ_A_ACRA405_1
(ACARBOSE/MALTOSE
BINDING PROTEIN GACH)		 3mpi GLUTARYL-COA
DEHYDROGENASE
(Desulfococcus
multivorans) 		5 / 12 PHE A 126
GLY A 125
GLU A 367
ALA A 249
GLY A 368
 FAD  A 400 ( 4.7A)
None
GRA  A 402 (-3.7A)
GRA  A 402 ( 4.8A)
GRA  A 402 (-3.5A)
 1.38A 3jzjA-3mpiA:
undetectable		 3jzjA-3mpiA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPD_B_SAMB1000_1
(UNCHARACTERIZED
PROTEIN MJ0100)		 3mpi GLUTARYL-COA
DEHYDROGENASE
(Desulfococcus
multivorans) 		3 / 3 ASN A  91
ASN A 162
GLU A  93
 GRA  A 402 (-3.8A)
None
None
 0.94A 3kpdC-3mpiA:
undetectable		 3kpdC-3mpiA:
15.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A7M_A_ACTA1923_0
(BETA-XYLOSIDASE)		 3mpi GLUTARYL-COA
DEHYDROGENASE
(Desulfococcus
multivorans) 		3 / 3 ASP A 233
ARG A 236
TYR A 104
 None
GRA  A 402 ( 4.1A)
None
 1.04A 5a7mA-3mpiA:
undetectable		 5a7mA-3mpiA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A7M_B_ACTB1924_0
(BETA-XYLOSIDASE)		 3mpi GLUTARYL-COA
DEHYDROGENASE
(Desulfococcus
multivorans) 		3 / 3 ASP A 233
ARG A 236
TYR A 104
 None
GRA  A 402 ( 4.1A)
None
 1.01A 5a7mB-3mpiA:
undetectable		 5a7mB-3mpiA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_B_SAMB301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 3mpi GLUTARYL-COA
DEHYDROGENASE
(Desulfococcus
multivorans) 		5 / 12 ALA A 144
ASP A 233
PRO A 231
GLY A 183
SER A 181
 None
None
None
None
GRA  A 402 (-2.6A)
 1.03A 5hfjB-3mpiA:
undetectable		 5hfjB-3mpiA:
21.58