SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'GPS'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
11GS_A_EAAA211_1
(GLUTATHIONE
S-TRANSFERASE)		 6gsw MU CLASS GLUTATHIONE
S-TRANSFERASE OF
ISOENZYME 3-3
(Rattus
rattus) 		4 / 7 TYR A   6
VAL A   9
ILE A 111
TYR A 115
 None
None
GPS  A 221 (-4.5A)
None
 0.89A 11gsA-6gswA:
25.7		 11gsA-6gswA:
30.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
13GS_A_SASA211_1
(GLUTATHIONE
S-TRANSFERASE)		 6gsw MU CLASS GLUTATHIONE
S-TRANSFERASE OF
ISOENZYME 3-3
(Rattus
rattus) 		5 / 10 TYR A   6
VAL A   9
ILE A 111
TYR A 115
PRO A 206
 None
None
GPS  A 221 (-4.5A)
None
None
 0.79A 13gsA-6gswA:
25.7		 13gsA-6gswA:
30.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GSS_A_EAAA0_1
(GLUTATHIONE
S-TRANSFERASE P1-1)		 6gsw MU CLASS GLUTATHIONE
S-TRANSFERASE OF
ISOENZYME 3-3
(Rattus
rattus) 		4 / 8 TYR A   6
VAL A   9
ILE A 111
TYR A 115
 None
None
GPS  A 221 (-4.5A)
None
 0.92A 2gssA-6gswA:
25.7		 2gssA-6gswA:
29.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GSS_B_EAAB0_1
(GLUTATHIONE
S-TRANSFERASE P1-1)		 6gsw MU CLASS GLUTATHIONE
S-TRANSFERASE OF
ISOENZYME 3-3
(Rattus
rattus) 		4 / 8 TYR A   6
VAL A   9
ILE A 111
TYR A 115
 None
None
GPS  A 221 (-4.5A)
None
 0.91A 2gssB-6gswA:
25.8		 2gssB-6gswA:
29.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CSJ_B_CBLB211_0
(GLUTATHIONE
S-TRANSFERASE P)		 6gsw MU CLASS GLUTATHIONE
S-TRANSFERASE OF
ISOENZYME 3-3
(Rattus
rattus) 		5 / 9 TYR A   6
VAL A   9
GLY A  11
ILE A 111
TYR A 115
 None
None
GPS  A 221 (-3.5A)
GPS  A 221 (-4.5A)
None
 0.87A 3csjB-6gswA:
25.7		 3csjB-6gswA:
29.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N9J_B_EAAB214_1
(GLUTATHIONE
S-TRANSFERASE P)		 6gsw MU CLASS GLUTATHIONE
S-TRANSFERASE OF
ISOENZYME 3-3
(Rattus
rattus) 		4 / 8 TYR A   6
VAL A   9
GLY A  11
ILE A 111
 None
None
GPS  A 221 (-3.5A)
GPS  A 221 (-4.5A)
 0.61A 3n9jB-6gswA:
25.6		 3n9jB-6gswA:
30.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K8C_A_ADNA401_2
(SUGAR KINASE)		 6gsw MU CLASS GLUTATHIONE
S-TRANSFERASE OF
ISOENZYME 3-3
(Rattus
rattus) 		3 / 3 SER A 209
TYR A  40
PRO A 206
 GPS  A 221 (-4.4A)
None
None
 0.98A 4k8cA-6gswA:
undetectable		 4k8cA-6gswA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAN_A_ADNA401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 6gsw MU CLASS GLUTATHIONE
S-TRANSFERASE OF
ISOENZYME 3-3
(Rattus
rattus) 		3 / 3 SER A 209
TYR A  40
PRO A 206
 GPS  A 221 (-4.4A)
None
None
 0.97A 4kanA-6gswA:
undetectable		 4kanA-6gswA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAN_B_ADNB401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 6gsw MU CLASS GLUTATHIONE
S-TRANSFERASE OF
ISOENZYME 3-3
(Rattus
rattus) 		3 / 3 SER A 209
TYR A  40
PRO A 206
 GPS  A 221 (-4.4A)
None
None
 0.97A 4kanB-6gswA:
undetectable		 4kanB-6gswA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JI0_A_9CRA501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1b4p PROTEIN (GLUTATHIONE
S-TRANSFERASE)
(Rattus
norvegicus) 		5 / 11 ILE A  16
LEU A 158
LEU A  79
ALA A  80
LEU A  12
 None
None
None
None
GPS  A 218 (-4.3A)
 1.24A 5ji0A-1b4pA:
undetectable		 5ji0A-1b4pA:
23.97