SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'GPP'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DY5_B_ACTB602_0
(RIBONUCLEASE A)		 1zcw AROMATIC
PRENYLTRANSFERASE
(Streptomyces
sp.
CL190) 		4 / 4 SER A 214
TYR A 175
GLN A 161
MET A 162
 None
GPP  A 401 (-4.7A)
None
GPP  A 401 ( 4.7A)
 1.40A 1dy5B-1zcwA:
0.0		 1dy5B-1zcwA:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_B_SAMB1293_1
(GLYCINE
N-METHYLTRANSFERASE)		 1zcw AROMATIC
PRENYLTRANSFERASE
(Streptomyces
sp.
CL190) 		4 / 5 ARG A 228
ASP A 110
SER A  64
SER A 164
 GPP  A 401 (-4.2A)
MG  A 501 ( 4.5A)
GPP  A 401 ( 4.2A)
GPP  A 401 ( 4.1A)
 1.23A 1kiaB-1zcwA:
undetectable		 1kiaB-1zcwA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_C_SAMC2293_1
(GLYCINE
N-METHYLTRANSFERASE)		 1zcw AROMATIC
PRENYLTRANSFERASE
(Streptomyces
sp.
CL190) 		4 / 6 ARG A 228
ASP A 110
SER A  64
SER A 164
 GPP  A 401 (-4.2A)
MG  A 501 ( 4.5A)
GPP  A 401 ( 4.2A)
GPP  A 401 ( 4.1A)
 1.23A 1kiaC-1zcwA:
1.0		 1kiaC-1zcwA:
22.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RQJ_A_RISA901_1
(GERANYLTRANSTRANSFER
ASE)		 3zou FARNESYL
PYROPHOSPHATE
SYNTHASE
(Pseudomonas
aeruginosa) 		8 / 11 SER A  79
LEU A  80
ASP A  83
ASP A  89
ARG A  94
GLN A 157
LYS A 180
THR A 181
 GPP  A1297 (-3.9A)
None
MG  A1295 (-2.5A)
MG  A1295 (-2.4A)
GPP  A1297 (-3.0A)
GPP  A1297 (-3.7A)
GPP  A1297 (-3.0A)
None
 0.67A 1rqjA-3zouA:
36.3		 1rqjA-3zouA:
52.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RQJ_B_RISB903_1
(GERANYLTRANSTRANSFER
ASE)		 3zou FARNESYL
PYROPHOSPHATE
SYNTHASE
(Pseudomonas
aeruginosa) 		7 / 11 SER A  79
LEU A  80
ASP A  83
ASP A  89
ARG A  94
GLN A 157
LYS A 180
 GPP  A1297 (-3.9A)
None
MG  A1295 (-2.5A)
MG  A1295 (-2.4A)
GPP  A1297 (-3.0A)
GPP  A1297 (-3.7A)
GPP  A1297 (-3.0A)
 0.68A 1rqjB-3zouA:
36.1		 1rqjB-3zouA:
52.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RQJ_B_RISB903_1
(GERANYLTRANSTRANSFER
ASE)		 3zou FARNESYL
PYROPHOSPHATE
SYNTHASE
(Pseudomonas
aeruginosa) 		7 / 11 SER A  79
LEU A  80
ASP A  83
ASP A  89
ARG A  94
LYS A 180
THR A 181
 GPP  A1297 (-3.9A)
None
MG  A1295 (-2.5A)
MG  A1295 (-2.4A)
GPP  A1297 (-3.0A)
GPP  A1297 (-3.0A)
None
 0.45A 1rqjB-3zouA:
36.1		 1rqjB-3zouA:
52.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YHL_A_RISA1400_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3zou FARNESYL
PYROPHOSPHATE
SYNTHASE
(Pseudomonas
aeruginosa) 		5 / 11 LEU A  80
ASP A  83
ASP A  89
ARG A  94
GLN A 157
 None
MG  A1295 (-2.5A)
MG  A1295 (-2.4A)
GPP  A1297 (-3.0A)
GPP  A1297 (-3.7A)
 0.45A 1yhlA-3zouA:
24.1		 1yhlA-3zouA:
25.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YHL_A_RISA1400_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3zou FARNESYL
PYROPHOSPHATE
SYNTHASE
(Pseudomonas
aeruginosa) 		6 / 11 LEU A  80
ASP A  83
ASP A  89
ARG A  94
LYS A 180
THR A 181
 None
MG  A1295 (-2.5A)
MG  A1295 (-2.4A)
GPP  A1297 (-3.0A)
GPP  A1297 (-3.0A)
None
 0.57A 1yhlA-3zouA:
24.1		 1yhlA-3zouA:
25.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YQ7_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHETASE)		 3zou FARNESYL
PYROPHOSPHATE
SYNTHASE
(Pseudomonas
aeruginosa) 		7 / 11 LEU A  80
ASP A  83
ASP A  89
ARG A  94
GLN A 157
LYS A 180
THR A 181
 None
MG  A1295 (-2.5A)
MG  A1295 (-2.4A)
GPP  A1297 (-3.0A)
GPP  A1297 (-3.7A)
GPP  A1297 (-3.0A)
None
 0.73A 1yq7A-3zouA:
23.0		 1yq7A-3zouA:
26.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YV5_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHETASE)		 3zou FARNESYL
PYROPHOSPHATE
SYNTHASE
(Pseudomonas
aeruginosa) 		6 / 10 LEU A  80
ASP A  83
ASP A  89
ARG A  94
GLN A 157
LYS A 180
 None
MG  A1295 (-2.5A)
MG  A1295 (-2.4A)
GPP  A1297 (-3.0A)
GPP  A1297 (-3.7A)
GPP  A1297 (-3.0A)
 0.66A 1yv5A-3zouA:
23.3		 1yv5A-3zouA:
26.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YV5_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHETASE)		 3zou FARNESYL
PYROPHOSPHATE
SYNTHASE
(Pseudomonas
aeruginosa) 		6 / 10 LEU A  80
ASP A  83
ASP A  89
ARG A  94
LYS A 180
THR A 181
 None
MG  A1295 (-2.5A)
MG  A1295 (-2.4A)
GPP  A1297 (-3.0A)
GPP  A1297 (-3.0A)
None
 0.54A 1yv5A-3zouA:
23.3		 1yv5A-3zouA:
26.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZW5_A_ZOLA901_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 3zou FARNESYL
PYROPHOSPHATE
SYNTHASE
(Pseudomonas
aeruginosa) 		5 / 9 ASP A  83
ASP A  89
ARG A  94
LYS A 180
THR A 181
 MG  A1295 (-2.5A)
MG  A1295 (-2.4A)
GPP  A1297 (-3.0A)
GPP  A1297 (-3.0A)
None
 0.60A 1zw5A-3zouA:
23.3		 1zw5A-3zouA:
27.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E91_A_ZOLA901_1
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE)		 3zou FARNESYL
PYROPHOSPHATE
SYNTHASE
(Pseudomonas
aeruginosa) 		5 / 9 ASP A  83
ASP A  89
ARG A  94
LYS A 180
THR A 181
 MG  A1295 (-2.5A)
MG  A1295 (-2.4A)
GPP  A1297 (-3.0A)
GPP  A1297 (-3.0A)
None
 0.56A 2e91A-3zouA:
18.6		 2e91A-3zouA:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E91_B_ZOLB902_1
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE)		 3zou FARNESYL
PYROPHOSPHATE
SYNTHASE
(Pseudomonas
aeruginosa) 		6 / 9 ASP A  83
ASP A  89
ARG A  94
GLN A 157
LYS A 180
THR A 181
 MG  A1295 (-2.5A)
MG  A1295 (-2.4A)
GPP  A1297 (-3.0A)
GPP  A1297 (-3.7A)
GPP  A1297 (-3.0A)
None
 0.68A 2e91B-3zouA:
17.9		 2e91B-3zouA:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F89_F_210F9001_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 3zou FARNESYL
PYROPHOSPHATE
SYNTHASE
(Pseudomonas
aeruginosa) 		5 / 9 ASP A  83
ASP A  89
ARG A  94
LYS A 180
THR A 181
 MG  A1295 (-2.5A)
MG  A1295 (-2.4A)
GPP  A1297 (-3.0A)
GPP  A1297 (-3.0A)
None
 0.48A 2f89F-3zouA:
24.3		 2f89F-3zouA:
28.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8C_F_ZOLF9001_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 3zou FARNESYL
PYROPHOSPHATE
SYNTHASE
(Pseudomonas
aeruginosa) 		7 / 11 LEU A  80
ASP A  83
ASP A  89
ARG A  94
GLN A 157
LYS A 180
THR A 181
 None
MG  A1295 (-2.5A)
MG  A1295 (-2.4A)
GPP  A1297 (-3.0A)
GPP  A1297 (-3.7A)
GPP  A1297 (-3.0A)
None
 0.76A 2f8cF-3zouA:
24.0		 2f8cF-3zouA:
28.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8Z_F_ZOLF5001_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 3zou FARNESYL
PYROPHOSPHATE
SYNTHASE
(Pseudomonas
aeruginosa) 		7 / 10 LEU A  80
ASP A  83
ASP A  89
ARG A  94
GLN A 157
LYS A 180
THR A 181
 None
MG  A1295 (-2.5A)
MG  A1295 (-2.4A)
GPP  A1297 (-3.0A)
GPP  A1297 (-3.7A)
GPP  A1297 (-3.0A)
None
 0.73A 2f8zF-3zouA:
24.2		 2f8zF-3zouA:
28.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F94_F_BFQF9001_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 3zou FARNESYL
PYROPHOSPHATE
SYNTHASE
(Pseudomonas
aeruginosa) 		7 / 12 LEU A  80
ASP A  83
ASP A  89
ARG A  94
GLN A 157
LYS A 180
THR A 181
 None
MG  A1295 (-2.5A)
MG  A1295 (-2.4A)
GPP  A1297 (-3.0A)
GPP  A1297 (-3.7A)
GPP  A1297 (-3.0A)
None
 0.49A 2f94F-3zouA:
23.6		 2f94F-3zouA:
28.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F9K_F_ZOLF9001_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 3zou FARNESYL
PYROPHOSPHATE
SYNTHASE
(Pseudomonas
aeruginosa) 		7 / 10 LEU A  80
ASP A  83
ASP A  89
ARG A  94
GLN A 157
LYS A 180
THR A 181
 None
MG  A1295 (-2.5A)
MG  A1295 (-2.4A)
GPP  A1297 (-3.0A)
GPP  A1297 (-3.7A)
GPP  A1297 (-3.0A)
None
 0.74A 2f9kF-3zouA:
23.9		 2f9kF-3zouA:
28.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O1O_A_RISA400_1
(PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3zou FARNESYL
PYROPHOSPHATE
SYNTHASE
(Pseudomonas
aeruginosa) 		6 / 9 LEU A  80
ASP A  83
ASP A  89
ARG A  94
GLN A 157
LYS A 180
 None
MG  A1295 (-2.5A)
MG  A1295 (-2.4A)
GPP  A1297 (-3.0A)
GPP  A1297 (-3.7A)
GPP  A1297 (-3.0A)
 0.63A 2o1oA-3zouA:
22.3		 2o1oA-3zouA:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O1O_A_RISA400_1
(PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3zou FARNESYL
PYROPHOSPHATE
SYNTHASE
(Pseudomonas
aeruginosa) 		6 / 9 LEU A  80
ASP A  83
ASP A  89
ARG A  94
LYS A 180
THR A 181
 None
MG  A1295 (-2.5A)
MG  A1295 (-2.4A)
GPP  A1297 (-3.0A)
GPP  A1297 (-3.0A)
None
 0.49A 2o1oA-3zouA:
22.3		 2o1oA-3zouA:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O1O_B_RISB400_1
(PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3zou FARNESYL
PYROPHOSPHATE
SYNTHASE
(Pseudomonas
aeruginosa) 		5 / 10 LEU A  80
ASP A  83
ASP A  89
ARG A  94
GLN A 157
 None
MG  A1295 (-2.5A)
MG  A1295 (-2.4A)
GPP  A1297 (-3.0A)
GPP  A1297 (-3.7A)
 0.52A 2o1oB-3zouA:
23.3		 2o1oB-3zouA:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O1O_B_RISB400_1
(PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3zou FARNESYL
PYROPHOSPHATE
SYNTHASE
(Pseudomonas
aeruginosa) 		6 / 10 LEU A  80
ASP A  83
ASP A  89
ARG A  94
LYS A 180
THR A 181
 None
MG  A1295 (-2.5A)
MG  A1295 (-2.4A)
GPP  A1297 (-3.0A)
GPP  A1297 (-3.0A)
None
 0.69A 2o1oB-3zouA:
23.3		 2o1oB-3zouA:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q58_A_ZOLA1_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3zou FARNESYL
PYROPHOSPHATE
SYNTHASE
(Pseudomonas
aeruginosa) 		5 / 10 LEU A  80
ASP A  83
ASP A  89
ARG A  94
GLN A 157
 None
MG  A1295 (-2.5A)
MG  A1295 (-2.4A)
GPP  A1297 (-3.0A)
GPP  A1297 (-3.7A)
 0.79A 2q58A-3zouA:
22.6		 2q58A-3zouA:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q58_A_ZOLA1_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3zou FARNESYL
PYROPHOSPHATE
SYNTHASE
(Pseudomonas
aeruginosa) 		6 / 10 LEU A  80
ASP A  83
ASP A  89
ARG A  94
LYS A 180
THR A 181
 None
MG  A1295 (-2.5A)
MG  A1295 (-2.4A)
GPP  A1297 (-3.0A)
GPP  A1297 (-3.0A)
None
 0.77A 2q58A-3zouA:
22.6		 2q58A-3zouA:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q58_B_ZOLB2_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3zou FARNESYL
PYROPHOSPHATE
SYNTHASE
(Pseudomonas
aeruginosa) 		5 / 9 ASP A  83
ASP A  89
ARG A  94
LYS A 180
THR A 181
 MG  A1295 (-2.5A)
MG  A1295 (-2.4A)
GPP  A1297 (-3.0A)
GPP  A1297 (-3.0A)
None
 0.72A 2q58B-3zouA:
23.0		 2q58B-3zouA:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QIS_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHETASE)		 3zou FARNESYL
PYROPHOSPHATE
SYNTHASE
(Pseudomonas
aeruginosa) 		5 / 10 LEU A  80
ASP A  83
ASP A  89
ARG A  94
GLN A 157
 None
MG  A1295 (-2.5A)
MG  A1295 (-2.4A)
GPP  A1297 (-3.0A)
GPP  A1297 (-3.7A)
 0.45A 2qisA-3zouA:
23.4		 2qisA-3zouA:
26.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QIS_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHETASE)		 3zou FARNESYL
PYROPHOSPHATE
SYNTHASE
(Pseudomonas
aeruginosa) 		5 / 10 LEU A  80
ASP A  83
ASP A  89
ARG A  94
LYS A 180
 None
MG  A1295 (-2.5A)
MG  A1295 (-2.4A)
GPP  A1297 (-3.0A)
GPP  A1297 (-3.0A)
 0.46A 2qisA-3zouA:
23.4		 2qisA-3zouA:
26.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AQI_A_CHDA2_0
(FERROCHELATASE)		 5xk8 UNDECAPRENYL
DIPHOSPHATE SYNTHASE
(Streptomyces
sp.
CNH189) 		4 / 6 MET A  69
ARG A 106
GLY A  89
MET A 123
 GPP  A 501 ( 3.7A)
None
None
None
 1.43A 3aqiA-5xk8A:
2.9		 3aqiA-5xk8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EZ3_A_ZOLA397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE, PUTATIVE)		 3zou FARNESYL
PYROPHOSPHATE
SYNTHASE
(Pseudomonas
aeruginosa) 		5 / 9 ASP A  83
ASP A  89
ARG A  94
LYS A 180
THR A 181
 MG  A1295 (-2.5A)
MG  A1295 (-2.4A)
GPP  A1297 (-3.0A)
GPP  A1297 (-3.0A)
None
 0.67A 3ez3A-3zouA:
23.1		 3ez3A-3zouA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EZ3_B_ZOLB397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE, PUTATIVE)		 3zou FARNESYL
PYROPHOSPHATE
SYNTHASE
(Pseudomonas
aeruginosa) 		5 / 9 ASP A  83
ASP A  89
ARG A  94
LYS A 180
THR A 181
 MG  A1295 (-2.5A)
MG  A1295 (-2.4A)
GPP  A1297 (-3.0A)
GPP  A1297 (-3.0A)
None
 0.57A 3ez3B-3zouA:
23.2		 3ez3B-3zouA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EZ3_C_ZOLC397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE, PUTATIVE)		 3zou FARNESYL
PYROPHOSPHATE
SYNTHASE
(Pseudomonas
aeruginosa) 		5 / 9 ASP A  83
ASP A  89
ARG A  94
LYS A 180
THR A 181
 MG  A1295 (-2.5A)
MG  A1295 (-2.4A)
GPP  A1297 (-3.0A)
GPP  A1297 (-3.0A)
None
 0.69A 3ez3C-3zouA:
23.1		 3ez3C-3zouA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EZ3_D_ZOLD397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE, PUTATIVE)		 3zou FARNESYL
PYROPHOSPHATE
SYNTHASE
(Pseudomonas
aeruginosa) 		5 / 10 LEU A  80
ASP A  83
ASP A  89
ARG A  94
GLN A 157
 None
MG  A1295 (-2.5A)
MG  A1295 (-2.4A)
GPP  A1297 (-3.0A)
GPP  A1297 (-3.7A)
 0.50A 3ez3D-3zouA:
23.1		 3ez3D-3zouA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EZ3_D_ZOLD397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE, PUTATIVE)		 3zou FARNESYL
PYROPHOSPHATE
SYNTHASE
(Pseudomonas
aeruginosa) 		6 / 10 LEU A  80
ASP A  83
ASP A  89
ARG A  94
LYS A 180
THR A 181
 None
MG  A1295 (-2.5A)
MG  A1295 (-2.4A)
GPP  A1297 (-3.0A)
GPP  A1297 (-3.0A)
None
 0.60A 3ez3D-3zouA:
23.1		 3ez3D-3zouA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IBA_A_ZOLA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3zou FARNESYL
PYROPHOSPHATE
SYNTHASE
(Pseudomonas
aeruginosa) 		5 / 10 ASP A  83
ASP A  89
ARG A  94
GLN A 157
LYS A 180
 MG  A1295 (-2.5A)
MG  A1295 (-2.4A)
GPP  A1297 (-3.0A)
GPP  A1297 (-3.7A)
GPP  A1297 (-3.0A)
 0.79A 3ibaA-3zouA:
23.9		 3ibaA-3zouA:
25.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IBA_A_ZOLA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3zou FARNESYL
PYROPHOSPHATE
SYNTHASE
(Pseudomonas
aeruginosa) 		5 / 10 ASP A  83
ASP A  89
ARG A  94
LYS A 180
THR A 181
 MG  A1295 (-2.5A)
MG  A1295 (-2.4A)
GPP  A1297 (-3.0A)
GPP  A1297 (-3.0A)
None
 0.52A 3ibaA-3zouA:
23.9		 3ibaA-3zouA:
25.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LDW_A_ZOLA397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3zou FARNESYL
PYROPHOSPHATE
SYNTHASE
(Pseudomonas
aeruginosa) 		5 / 9 ASP A  83
ASP A  89
ARG A  94
LYS A 180
THR A 181
 MG  A1295 (-2.5A)
MG  A1295 (-2.4A)
GPP  A1297 (-3.0A)
GPP  A1297 (-3.0A)
None
 0.68A 3ldwA-3zouA:
23.0		 3ldwA-3zouA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LDW_B_ZOLB397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3zou FARNESYL
PYROPHOSPHATE
SYNTHASE
(Pseudomonas
aeruginosa) 		5 / 9 ASP A  83
ASP A  89
ARG A  94
LYS A 180
THR A 181
 MG  A1295 (-2.5A)
MG  A1295 (-2.4A)
GPP  A1297 (-3.0A)
GPP  A1297 (-3.0A)
None
 0.59A 3ldwB-3zouA:
23.2		 3ldwB-3zouA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LDW_C_ZOLC397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3zou FARNESYL
PYROPHOSPHATE
SYNTHASE
(Pseudomonas
aeruginosa) 		5 / 9 ASP A  83
ASP A  89
ARG A  94
LYS A 180
THR A 181
 MG  A1295 (-2.5A)
MG  A1295 (-2.4A)
GPP  A1297 (-3.0A)
GPP  A1297 (-3.0A)
None
 0.69A 3ldwC-3zouA:
23.2		 3ldwC-3zouA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LDW_D_ZOLD397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3zou FARNESYL
PYROPHOSPHATE
SYNTHASE
(Pseudomonas
aeruginosa) 		5 / 9 ASP A  83
ASP A  89
ARG A  94
LYS A 180
THR A 181
 MG  A1295 (-2.5A)
MG  A1295 (-2.4A)
GPP  A1297 (-3.0A)
GPP  A1297 (-3.0A)
None
 0.61A 3ldwD-3zouA:
23.0		 3ldwD-3zouA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N45_F_ZOLF354_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3zou FARNESYL
PYROPHOSPHATE
SYNTHASE
(Pseudomonas
aeruginosa) 		6 / 11 LEU A  80
ASP A  83
ASP A  89
ARG A  94
GLN A 157
LYS A 180
 None
MG  A1295 (-2.5A)
MG  A1295 (-2.4A)
GPP  A1297 (-3.0A)
GPP  A1297 (-3.7A)
GPP  A1297 (-3.0A)
 0.72A 3n45F-3zouA:
23.8		 3n45F-3zouA:
28.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N45_F_ZOLF354_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3zou FARNESYL
PYROPHOSPHATE
SYNTHASE
(Pseudomonas
aeruginosa) 		6 / 11 LEU A  80
ASP A  83
ASP A  89
ARG A  94
LYS A 180
THR A 181
 None
MG  A1295 (-2.5A)
MG  A1295 (-2.4A)
GPP  A1297 (-3.0A)
GPP  A1297 (-3.0A)
None
 0.58A 3n45F-3zouA:
23.8		 3n45F-3zouA:
28.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N46_F_ZOLF354_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3zou FARNESYL
PYROPHOSPHATE
SYNTHASE
(Pseudomonas
aeruginosa) 		7 / 10 LEU A  80
ASP A  83
ASP A  89
ARG A  94
GLN A 157
LYS A 180
THR A 181
 None
MG  A1295 (-2.5A)
MG  A1295 (-2.4A)
GPP  A1297 (-3.0A)
GPP  A1297 (-3.7A)
GPP  A1297 (-3.0A)
None
 0.75A 3n46F-3zouA:
23.9		 3n46F-3zouA:
28.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7T_A_5FWA1000_1
(SUPEROXIDE DISMUTASE
[CU-ZN])		 5gp0 NUDIX HYDROLASE 1
(Arabidopsis
thaliana) 		4 / 6 GLU E  60
PRO E 108
LYS E 110
GLU E 109
 None
None
GPP  E 202 ( 4.3A)
None
 1.37A 4a7tA-5gp0E:
undetectable		 4a7tA-5gp0E:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KFA_A_ZOLA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3zou FARNESYL
PYROPHOSPHATE
SYNTHASE
(Pseudomonas
aeruginosa) 		6 / 9 LEU A  80
ASP A  83
ASP A  89
ARG A  94
GLN A 157
LYS A 180
 None
MG  A1295 (-2.5A)
MG  A1295 (-2.4A)
GPP  A1297 (-3.0A)
GPP  A1297 (-3.7A)
GPP  A1297 (-3.0A)
 0.66A 4kfaA-3zouA:
22.9		 4kfaA-3zouA:
26.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KPD_A_RISA405_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3zou FARNESYL
PYROPHOSPHATE
SYNTHASE
(Pseudomonas
aeruginosa) 		5 / 10 LEU A  80
ASP A  83
ASP A  89
ARG A  94
GLN A 157
 None
MG  A1295 (-2.5A)
MG  A1295 (-2.4A)
GPP  A1297 (-3.0A)
GPP  A1297 (-3.7A)
 0.49A 4kpdA-3zouA:
24.0		 4kpdA-3zouA:
26.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KPD_A_RISA405_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3zou FARNESYL
PYROPHOSPHATE
SYNTHASE
(Pseudomonas
aeruginosa) 		6 / 10 LEU A  80
ASP A  83
ASP A  89
ARG A  94
LYS A 180
THR A 181
 None
MG  A1295 (-2.5A)
MG  A1295 (-2.4A)
GPP  A1297 (-3.0A)
GPP  A1297 (-3.0A)
None
 0.55A 4kpdA-3zouA:
24.0		 4kpdA-3zouA:
26.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KPJ_A_210A901_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3zou FARNESYL
PYROPHOSPHATE
SYNTHASE
(Pseudomonas
aeruginosa) 		6 / 9 LEU A  80
ASP A  83
ASP A  89
ARG A  94
LYS A 180
THR A 181
 None
MG  A1295 (-2.5A)
MG  A1295 (-2.4A)
GPP  A1297 (-3.0A)
GPP  A1297 (-3.0A)
None
 0.53A 4kpjA-3zouA:
23.3		 4kpjA-3zouA:
27.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KQ5_A_ZOLA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3zou FARNESYL
PYROPHOSPHATE
SYNTHASE
(Pseudomonas
aeruginosa) 		7 / 10 LEU A  80
ASP A  83
ASP A  89
ARG A  94
GLN A 157
LYS A 180
THR A 181
 None
MG  A1295 (-2.5A)
MG  A1295 (-2.4A)
GPP  A1297 (-3.0A)
GPP  A1297 (-3.7A)
GPP  A1297 (-3.0A)
None
 0.74A 4kq5A-3zouA:
23.4		 4kq5A-3zouA:
27.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KQS_A_RISA405_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3zou FARNESYL
PYROPHOSPHATE
SYNTHASE
(Pseudomonas
aeruginosa) 		5 / 10 LEU A  80
ASP A  83
ASP A  89
ARG A  94
GLN A 157
 None
MG  A1295 (-2.5A)
MG  A1295 (-2.4A)
GPP  A1297 (-3.0A)
GPP  A1297 (-3.7A)
 0.43A 4kqsA-3zouA:
23.8		 4kqsA-3zouA:
27.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KQS_A_RISA405_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3zou FARNESYL
PYROPHOSPHATE
SYNTHASE
(Pseudomonas
aeruginosa) 		6 / 10 LEU A  80
ASP A  83
ASP A  89
ARG A  94
LYS A 180
THR A 181
 None
MG  A1295 (-2.5A)
MG  A1295 (-2.4A)
GPP  A1297 (-3.0A)
GPP  A1297 (-3.0A)
None
 0.54A 4kqsA-3zouA:
23.8		 4kqsA-3zouA:
27.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N9U_A_RISA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3zou FARNESYL
PYROPHOSPHATE
SYNTHASE
(Pseudomonas
aeruginosa) 		5 / 10 LEU A  80
ASP A  83
ASP A  89
ARG A  94
GLN A 157
 None
MG  A1295 (-2.5A)
MG  A1295 (-2.4A)
GPP  A1297 (-3.0A)
GPP  A1297 (-3.7A)
 0.47A 4n9uA-3zouA:
23.4		 4n9uA-3zouA:
27.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N9U_A_RISA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3zou FARNESYL
PYROPHOSPHATE
SYNTHASE
(Pseudomonas
aeruginosa) 		5 / 10 LEU A  80
ASP A  83
ASP A  89
ARG A  94
THR A 181
 None
MG  A1295 (-2.5A)
MG  A1295 (-2.4A)
GPP  A1297 (-3.0A)
None
 0.55A 4n9uA-3zouA:
23.4		 4n9uA-3zouA:
27.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N9U_A_RISA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3zou FARNESYL
PYROPHOSPHATE
SYNTHASE
(Pseudomonas
aeruginosa) 		5 / 10 LEU A  80
ASP A  83
ASP A  89
ARG A  94
THR A 181
 None
MG  A1295 (-2.5A)
MG  A1295 (-2.4A)
GPP  A1297 (-3.0A)
None
 1.23A 4n9uA-3zouA:
23.4		 4n9uA-3zouA:
27.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NG6_A_RISA405_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3zou FARNESYL
PYROPHOSPHATE
SYNTHASE
(Pseudomonas
aeruginosa) 		6 / 12 LEU A  80
ASP A  83
ASP A  89
ARG A  94
GLN A 157
THR A 181
 None
MG  A1295 (-2.5A)
MG  A1295 (-2.4A)
GPP  A1297 (-3.0A)
GPP  A1297 (-3.7A)
None
 0.44A 4ng6A-3zouA:
23.5		 4ng6A-3zouA:
26.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NG6_A_RISA405_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3zou FARNESYL
PYROPHOSPHATE
SYNTHASE
(Pseudomonas
aeruginosa) 		5 / 12 LEU A  80
ASP A  83
ASP A  89
ARG A  94
THR A 181
 None
MG  A1295 (-2.5A)
MG  A1295 (-2.4A)
GPP  A1297 (-3.0A)
None
 1.24A 4ng6A-3zouA:
23.5		 4ng6A-3zouA:
26.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKE_A_RISA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3zou FARNESYL
PYROPHOSPHATE
SYNTHASE
(Pseudomonas
aeruginosa) 		6 / 10 LEU A  80
ASP A  83
ASP A  89
ARG A  94
GLN A 157
LYS A 180
 None
MG  A1295 (-2.5A)
MG  A1295 (-2.4A)
GPP  A1297 (-3.0A)
GPP  A1297 (-3.7A)
GPP  A1297 (-3.0A)
 0.69A 4nkeA-3zouA:
23.4		 4nkeA-3zouA:
26.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKE_A_RISA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3zou FARNESYL
PYROPHOSPHATE
SYNTHASE
(Pseudomonas
aeruginosa) 		6 / 10 LEU A  80
ASP A  83
ASP A  89
ARG A  94
LYS A 180
THR A 181
 None
MG  A1295 (-2.5A)
MG  A1295 (-2.4A)
GPP  A1297 (-3.0A)
GPP  A1297 (-3.0A)
None
 0.54A 4nkeA-3zouA:
23.4		 4nkeA-3zouA:
26.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKF_A_210A404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3zou FARNESYL
PYROPHOSPHATE
SYNTHASE
(Pseudomonas
aeruginosa) 		6 / 9 LEU A  80
ASP A  83
ASP A  89
ARG A  94
LYS A 180
THR A 181
 None
MG  A1295 (-2.5A)
MG  A1295 (-2.4A)
GPP  A1297 (-3.0A)
GPP  A1297 (-3.0A)
None
 0.59A 4nkfA-3zouA:
23.7		 4nkfA-3zouA:
26.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NUA_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3zou FARNESYL
PYROPHOSPHATE
SYNTHASE
(Pseudomonas
aeruginosa) 		5 / 10 LEU A  80
ASP A  83
ASP A  89
ARG A  94
GLN A 157
 None
MG  A1295 (-2.5A)
MG  A1295 (-2.4A)
GPP  A1297 (-3.0A)
GPP  A1297 (-3.7A)
 0.42A 4nuaA-3zouA:
23.4		 4nuaA-3zouA:
26.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NUA_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3zou FARNESYL
PYROPHOSPHATE
SYNTHASE
(Pseudomonas
aeruginosa) 		6 / 10 LEU A  80
ASP A  83
ASP A  89
ARG A  94
LYS A 180
THR A 181
 None
MG  A1295 (-2.5A)
MG  A1295 (-2.4A)
GPP  A1297 (-3.0A)
GPP  A1297 (-3.0A)
None
 0.53A 4nuaA-3zouA:
23.4		 4nuaA-3zouA:
26.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OGU_A_210A405_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3zou FARNESYL
PYROPHOSPHATE
SYNTHASE
(Pseudomonas
aeruginosa) 		6 / 9 LEU A  80
ASP A  83
ASP A  89
ARG A  94
LYS A 180
THR A 181
 None
MG  A1295 (-2.5A)
MG  A1295 (-2.4A)
GPP  A1297 (-3.0A)
GPP  A1297 (-3.0A)
None
 0.61A 4oguA-3zouA:
23.5		 4oguA-3zouA:
26.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P0V_A_ZOLA401_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3zou FARNESYL
PYROPHOSPHATE
SYNTHASE
(Pseudomonas
aeruginosa) 		6 / 9 ASP A  83
ASP A  89
ARG A  94
GLN A 157
LYS A 180
THR A 181
 MG  A1295 (-2.5A)
MG  A1295 (-2.4A)
GPP  A1297 (-3.0A)
GPP  A1297 (-3.7A)
GPP  A1297 (-3.0A)
None
 0.75A 4p0vA-3zouA:
24.1		 4p0vA-3zouA:
28.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P0W_A_ZOLA501_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3zou FARNESYL
PYROPHOSPHATE
SYNTHASE
(Pseudomonas
aeruginosa) 		7 / 11 LEU A  80
ASP A  83
ASP A  89
ARG A  94
GLN A 157
LYS A 180
THR A 181
 None
MG  A1295 (-2.5A)
MG  A1295 (-2.4A)
GPP  A1297 (-3.0A)
GPP  A1297 (-3.7A)
GPP  A1297 (-3.0A)
None
 0.77A 4p0wA-3zouA:
24.0		 4p0wA-3zouA:
28.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q23_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3zou FARNESYL
PYROPHOSPHATE
SYNTHASE
(Pseudomonas
aeruginosa) 		6 / 10 LEU A  80
ASP A  83
ASP A  89
ARG A  94
GLN A 157
LYS A 180
 None
MG  A1295 (-2.5A)
MG  A1295 (-2.4A)
GPP  A1297 (-3.0A)
GPP  A1297 (-3.7A)
GPP  A1297 (-3.0A)
 0.67A 4q23A-3zouA:
23.2		 4q23A-3zouA:
26.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RXD_A_RISA1404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3zou FARNESYL
PYROPHOSPHATE
SYNTHASE
(Pseudomonas
aeruginosa) 		6 / 10 LEU A  80
ASP A  83
ASP A  89
ARG A  94
GLN A 157
LYS A 180
 None
MG  A1295 (-2.5A)
MG  A1295 (-2.4A)
GPP  A1297 (-3.0A)
GPP  A1297 (-3.7A)
GPP  A1297 (-3.0A)
 0.71A 4rxdA-3zouA:
7.2		 4rxdA-3zouA:
24.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RXD_A_RISA1404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3zou FARNESYL
PYROPHOSPHATE
SYNTHASE
(Pseudomonas
aeruginosa) 		6 / 10 LEU A  80
ASP A  83
ASP A  89
ARG A  94
LYS A 180
THR A 181
 None
MG  A1295 (-2.5A)
MG  A1295 (-2.4A)
GPP  A1297 (-3.0A)
GPP  A1297 (-3.0A)
None
 0.52A 4rxdA-3zouA:
7.2		 4rxdA-3zouA:
24.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RXD_B_RISB1504_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3zou FARNESYL
PYROPHOSPHATE
SYNTHASE
(Pseudomonas
aeruginosa) 		7 / 10 LEU A  80
ASP A  83
ASP A  89
ARG A  94
GLN A 157
LYS A 180
THR A 181
 None
MG  A1295 (-2.5A)
MG  A1295 (-2.4A)
GPP  A1297 (-3.0A)
GPP  A1297 (-3.7A)
GPP  A1297 (-3.0A)
None
 0.74A 4rxdB-3zouA:
23.6		 4rxdB-3zouA:
24.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RXD_C_RISC1600_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3zou FARNESYL
PYROPHOSPHATE
SYNTHASE
(Pseudomonas
aeruginosa) 		5 / 10 LEU A  80
ASP A  83
ASP A  89
ARG A  94
GLN A 157
 None
MG  A1295 (-2.5A)
MG  A1295 (-2.4A)
GPP  A1297 (-3.0A)
GPP  A1297 (-3.7A)
 0.46A 4rxdC-3zouA:
23.7		 4rxdC-3zouA:
24.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RXD_C_RISC1600_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3zou FARNESYL
PYROPHOSPHATE
SYNTHASE
(Pseudomonas
aeruginosa) 		6 / 10 LEU A  80
ASP A  83
ASP A  89
ARG A  94
LYS A 180
THR A 181
 None
MG  A1295 (-2.5A)
MG  A1295 (-2.4A)
GPP  A1297 (-3.0A)
GPP  A1297 (-3.0A)
None
 0.51A 4rxdC-3zouA:
23.7		 4rxdC-3zouA:
24.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4UMJ_A_BFQA1297_1
(GERANYLTRANSTRANSFER
ASE)		 3zou FARNESYL
PYROPHOSPHATE
SYNTHASE
(Pseudomonas
aeruginosa) 		8 / 8 SER A  79
LEU A  80
ASP A  83
ASP A  89
ARG A  94
MET A 153
GLN A 157
LYS A 180
 GPP  A1297 (-3.9A)
None
MG  A1295 (-2.5A)
MG  A1295 (-2.4A)
GPP  A1297 (-3.0A)
GPP  A1297 ( 4.6A)
GPP  A1297 (-3.7A)
GPP  A1297 (-3.0A)
 0.34A 4umjA-3zouA:
47.3		 4umjA-3zouA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4UMJ_B_BFQB1294_1
(GERANYLTRANSTRANSFER
ASE)		 3zou FARNESYL
PYROPHOSPHATE
SYNTHASE
(Pseudomonas
aeruginosa) 		9 / 9 SER A  79
LEU A  80
ASP A  83
ASP A  89
ARG A  94
MET A 153
GLN A 157
LYS A 180
THR A 181
 GPP  A1297 (-3.9A)
None
MG  A1295 (-2.5A)
MG  A1295 (-2.4A)
GPP  A1297 (-3.0A)
GPP  A1297 ( 4.6A)
GPP  A1297 (-3.7A)
GPP  A1297 (-3.0A)
None
 0.34A 4umjB-3zouA:
46.7		 4umjB-3zouA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CG5_A_RISA400_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3zou FARNESYL
PYROPHOSPHATE
SYNTHASE
(Pseudomonas
aeruginosa) 		6 / 12 LEU A  80
ASP A  83
ASP A  89
ARG A  94
GLN A 157
LYS A 180
 None
MG  A1295 (-2.5A)
MG  A1295 (-2.4A)
GPP  A1297 (-3.0A)
GPP  A1297 (-3.7A)
GPP  A1297 (-3.0A)
 0.67A 5cg5A-3zouA:
23.0		 5cg5A-3zouA:
28.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CG5_A_RISA400_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3zou FARNESYL
PYROPHOSPHATE
SYNTHASE
(Pseudomonas
aeruginosa) 		6 / 12 LEU A  80
ASP A  83
ASP A  89
ARG A  94
LYS A 180
THR A 181
 None
MG  A1295 (-2.5A)
MG  A1295 (-2.4A)
GPP  A1297 (-3.0A)
GPP  A1297 (-3.0A)
None
 0.51A 5cg5A-3zouA:
23.0		 5cg5A-3zouA:
28.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CG5_A_RISA400_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3zou FARNESYL
PYROPHOSPHATE
SYNTHASE
(Pseudomonas
aeruginosa) 		5 / 12 LEU A  80
ASP A  83
ASP A  89
ARG A  94
THR A 181
 None
MG  A1295 (-2.5A)
MG  A1295 (-2.4A)
GPP  A1297 (-3.0A)
None
 1.22A 5cg5A-3zouA:
23.0		 5cg5A-3zouA:
28.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CG6_A_RISA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3zou FARNESYL
PYROPHOSPHATE
SYNTHASE
(Pseudomonas
aeruginosa) 		6 / 12 LEU A  80
ASP A  83
ASP A  89
ARG A  94
GLN A 157
LYS A 180
 None
MG  A1295 (-2.5A)
MG  A1295 (-2.4A)
GPP  A1297 (-3.0A)
GPP  A1297 (-3.7A)
GPP  A1297 (-3.0A)
 0.66A 5cg6A-3zouA:
23.7		 5cg6A-3zouA:
28.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CG6_A_RISA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3zou FARNESYL
PYROPHOSPHATE
SYNTHASE
(Pseudomonas
aeruginosa) 		6 / 12 LEU A  80
ASP A  83
ASP A  89
ARG A  94
LYS A 180
THR A 181
 None
MG  A1295 (-2.5A)
MG  A1295 (-2.4A)
GPP  A1297 (-3.0A)
GPP  A1297 (-3.0A)
None
 0.50A 5cg6A-3zouA:
23.7		 5cg6A-3zouA:
28.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E8Q_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 3zou FARNESYL
PYROPHOSPHATE
SYNTHASE
(Pseudomonas
aeruginosa) 		3 / 3 ASP A 222
LEU A  80
ARG A  94
 None
None
GPP  A1297 (-3.0A)
 0.40A 5e8qA-3zouA:
undetectable		 5e8qA-3zouA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERO_A_210A804_1
(FUSICOCCADIENE
SYNTHASE)		 3zou FARNESYL
PYROPHOSPHATE
SYNTHASE
(Pseudomonas
aeruginosa) 		5 / 9 LEU A  80
ASP A  83
ASP A  89
ARG A  94
LYS A 180
 None
MG  A1295 (-2.5A)
MG  A1295 (-2.4A)
GPP  A1297 (-3.0A)
GPP  A1297 (-3.0A)
 0.69A 5eroA-3zouA:
21.5		 5eroA-3zouA:
25.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERO_C_210C804_1
(FUSICOCCADIENE
SYNTHASE)		 3zou FARNESYL
PYROPHOSPHATE
SYNTHASE
(Pseudomonas
aeruginosa) 		5 / 10 ASP A  83
ASP A  84
ASP A  89
ARG A  94
LYS A 180
 MG  A1295 (-2.5A)
None
MG  A1295 (-2.4A)
GPP  A1297 (-3.0A)
GPP  A1297 (-3.0A)
 0.67A 5eroC-3zouA:
21.5		 5eroC-3zouA:
25.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L66_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 2gzl 2-C-METHYL-D-ERYTHRI
TOL
2,4-CYCLODIPHOSPHATE
SYNTHASE
(Escherichia
coli) 		5 / 11 THR A 134
THR A 133
THR A 132
ARG A 142
GLY A 143
 GPP  A 903 (-3.8A)
None
None
GPP  A 903 (-3.0A)
None
 1.48A 5l66H-2gzlA:
undetectable
5l66N-2gzlA:
undetectable		 5l66H-2gzlA:
23.27
5l66N-2gzlA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XXI_A_LSNA503_1
(CYTOCHROME P450 2C9)		 5gp0 NUDIX HYDROLASE 1
(Arabidopsis
thaliana) 		5 / 12 ASN E 139
LEU E  23
PRO E  39
LEU E 130
PHE E  15
 None
None
None
GPP  E 202 ( 4.2A)
None
 1.14A 5xxiA-5gp0E:
undetectable		 5xxiA-5gp0E:
14.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_A_ZOLA401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 3zou FARNESYL
PYROPHOSPHATE
SYNTHASE
(Pseudomonas
aeruginosa) 		5 / 7 ASP A  83
ASP A  89
ARG A  94
GLN A 157
LYS A 180
 MG  A1295 (-2.5A)
MG  A1295 (-2.4A)
GPP  A1297 (-3.0A)
GPP  A1297 (-3.7A)
GPP  A1297 (-3.0A)
 0.74A 6g31A-3zouA:
21.4		 6g31A-3zouA:
14.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_B_ZOLB401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 3zou FARNESYL
PYROPHOSPHATE
SYNTHASE
(Pseudomonas
aeruginosa) 		4 / 6 ASP A  83
ASP A  89
ARG A  94
GLN A 157
 MG  A1295 (-2.5A)
MG  A1295 (-2.4A)
GPP  A1297 (-3.0A)
GPP  A1297 (-3.7A)
 0.47A 6g31B-3zouA:
21.5		 6g31B-3zouA:
14.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_C_ZOLC401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 3zou FARNESYL
PYROPHOSPHATE
SYNTHASE
(Pseudomonas
aeruginosa) 		5 / 5 ASP A  83
ASP A  89
ARG A  94
GLN A 157
LYS A 180
 MG  A1295 (-2.5A)
MG  A1295 (-2.4A)
GPP  A1297 (-3.0A)
GPP  A1297 (-3.7A)
GPP  A1297 (-3.0A)
 1.00A 6g31C-3zouA:
21.4		 6g31C-3zouA:
14.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_D_ZOLD401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 3zou FARNESYL
PYROPHOSPHATE
SYNTHASE
(Pseudomonas
aeruginosa) 		5 / 7 LEU A  80
ASP A  83
ASP A  89
ARG A  94
GLN A 157
 None
MG  A1295 (-2.5A)
MG  A1295 (-2.4A)
GPP  A1297 (-3.0A)
GPP  A1297 (-3.7A)
 0.41A 6g31D-3zouA:
20.8		 6g31D-3zouA:
14.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_E_ZOLE401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 3zou FARNESYL
PYROPHOSPHATE
SYNTHASE
(Pseudomonas
aeruginosa) 		4 / 4 LEU A  80
ASP A  83
ASP A  89
ARG A  94
 None
MG  A1295 (-2.5A)
MG  A1295 (-2.4A)
GPP  A1297 (-3.0A)
 0.29A 6g31E-3zouA:
16.2		 6g31E-3zouA:
14.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_F_ZOLF401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 3zou FARNESYL
PYROPHOSPHATE
SYNTHASE
(Pseudomonas
aeruginosa) 		4 / 5 ASP A  83
ASP A  89
ARG A  94
GLN A 157
 MG  A1295 (-2.5A)
MG  A1295 (-2.4A)
GPP  A1297 (-3.0A)
GPP  A1297 (-3.7A)
 0.56A 6g31F-3zouA:
21.6		 6g31F-3zouA:
14.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_G_ZOLG401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 3zou FARNESYL
PYROPHOSPHATE
SYNTHASE
(Pseudomonas
aeruginosa) 		4 / 7 ASP A  83
ASP A  89
ARG A  94
GLN A 157
 MG  A1295 (-2.5A)
MG  A1295 (-2.4A)
GPP  A1297 (-3.0A)
GPP  A1297 (-3.7A)
 0.42A 6g31G-3zouA:
20.7		 6g31G-3zouA:
14.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_G_ZOLG401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 3zou FARNESYL
PYROPHOSPHATE
SYNTHASE
(Pseudomonas
aeruginosa) 		4 / 7 ASP A  83
ASP A  89
ARG A  94
LYS A 180
 MG  A1295 (-2.5A)
MG  A1295 (-2.4A)
GPP  A1297 (-3.0A)
GPP  A1297 (-3.0A)
 0.66A 6g31G-3zouA:
20.7		 6g31G-3zouA:
14.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_J_ZOLJ401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 3zou FARNESYL
PYROPHOSPHATE
SYNTHASE
(Pseudomonas
aeruginosa) 		5 / 6 LEU A  80
ASP A  83
ASP A  89
ARG A  94
GLN A 157
 None
MG  A1295 (-2.5A)
MG  A1295 (-2.4A)
GPP  A1297 (-3.0A)
GPP  A1297 (-3.7A)
 0.66A 6g31J-3zouA:
21.5		 6g31J-3zouA:
14.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_K_ZOLK401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 3zou FARNESYL
PYROPHOSPHATE
SYNTHASE
(Pseudomonas
aeruginosa) 		4 / 4 ASP A  83
ASP A  89
ARG A  94
GLN A 157
 MG  A1295 (-2.5A)
MG  A1295 (-2.4A)
GPP  A1297 (-3.0A)
GPP  A1297 (-3.7A)
 0.43A 6g31K-3zouA:
20.2		 6g31K-3zouA:
14.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_L_ZOLL401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 3zou FARNESYL
PYROPHOSPHATE
SYNTHASE
(Pseudomonas
aeruginosa) 		4 / 6 ASP A  83
ASP A  89
ARG A  94
GLN A 157
 MG  A1295 (-2.5A)
MG  A1295 (-2.4A)
GPP  A1297 (-3.0A)
GPP  A1297 (-3.7A)
 0.57A 6g31L-3zouA:
21.6		 6g31L-3zouA:
14.34