SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'GPL'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7A_A_PFLA4002_1
(SERUM ALBUMIN)		 4pz7 MRNA-CAPPING ENZYME
SUBUNIT ALPHA
(Schizosaccharomy
ces
pombe) 		3 / 3 PHE A 144
LEU A 147
SER A  44
 GPL  A  67 ( 3.3A)
None
GPL  A  67 ( 4.9A)
 0.90A 1e7aA-4pz7A:
undetectable		 1e7aA-4pz7A:
23.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E5D_A_NCAA1501_0
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 4pz7 MRNA-CAPPING ENZYME
SUBUNIT ALPHA
(Schizosaccharomy
ces
pombe) 		4 / 7 ARG A  72
ASP A 145
ASP A 124
TYR A 230
 GPL  A  67 (-4.6A)
None
None
None
 1.06A 2e5dA-4pz7A:
undetectable
2e5dB-4pz7A:
undetectable		 2e5dA-4pz7A:
23.68
2e5dB-4pz7A:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E5D_B_NCAB1502_0
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 4pz7 MRNA-CAPPING ENZYME
SUBUNIT ALPHA
(Schizosaccharomy
ces
pombe) 		4 / 7 ASP A 124
TYR A 230
ARG A  72
ASP A 145
 None
None
GPL  A  67 (-4.6A)
None
 1.07A 2e5dA-4pz7A:
undetectable
2e5dB-4pz7A:
undetectable		 2e5dA-4pz7A:
23.68
2e5dB-4pz7A:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J9D_A_ACTA1117_0
(HYPOTHETICAL
NITROGEN REGULATORY
PII-LIKE PROTEIN
MJ0059)		 4pz7 MRNA-CAPPING ENZYME
SUBUNIT ALPHA
(Schizosaccharomy
ces
pombe) 		3 / 3 ASP A  93
ARG A  72
ARG A  94
 None
GPL  A  67 (-4.6A)
None
 1.06A 2j9dA-4pz7A:
undetectable
2j9dC-4pz7A:
undetectable		 2j9dA-4pz7A:
14.07
2j9dC-4pz7A:
14.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O8F_A_BRLA501_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4pz7 MRNA-CAPPING ENZYME
SUBUNIT ALPHA
(Schizosaccharomy
ces
pombe) 		4 / 5 GLY A 125
LEU A 159
LEU A 238
LEU A  34
 None
None
GPL  A  67 ( 4.7A)
None
 0.86A 4o8fA-4pz7A:
undetectable		 4o8fA-4pz7A:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BPH_A_ACTA403_0
(D-ALANINE--D-ALANINE
LIGASE)		 4pz7 MRNA-CAPPING ENZYME
SUBUNIT ALPHA
(Schizosaccharomy
ces
pombe) 		4 / 6 TYR A 230
ARG A  72
GLY A 125
LEU A  74
 None
GPL  A  67 (-4.6A)
None
None
 1.21A 5bphA-4pz7A:
undetectable		 5bphA-4pz7A:
22.25