SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'GPJ'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OBV_A_SAMA501_0
(S-ADENOSYLMETHIONINE
SYNTHETASE ISOFORM
TYPE-1)		 3nvs 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE
(Vibrio
cholerae) 		4 / 8 HIS A 386
LYS A 412
SER A  25
ASP A 314
 GPJ  A 429 (-4.3A)
GPJ  A 429 (-2.9A)
None
SKM  A 428 (-2.7A)
 1.07A 2obvA-3nvsA:
undetectable		 2obvA-3nvsA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2P02_A_SAMA2_0
(S-ADENOSYLMETHIONINE
SYNTHETASE ISOFORM
TYPE-2)		 3nvs 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE
(Vibrio
cholerae) 		4 / 8 HIS A 386
LYS A 412
SER A  25
ASP A 314
 GPJ  A 429 (-4.3A)
GPJ  A 429 (-2.9A)
None
SKM  A 428 (-2.7A)
 1.11A 2p02A-3nvsA:
undetectable		 2p02A-3nvsA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q63_A_1UNA1001_4
(PROTEASE RETROPEPSIN)		 3nvs 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE
(Vibrio
cholerae) 		3 / 3 ASP A  49
ASN A  26
THR A 175
 GPJ  A 429 ( 4.7A)
None
S3P  A 427 ( 4.6A)
 0.67A 2q63B-3nvsA:
undetectable		 2q63B-3nvsA:
11.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HAM_A_LLLA500_1
(AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		 3nvs 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE
(Vibrio
cholerae) 		5 / 12 ASP A  49
SER A  47
ASP A 243
SER A 246
ARG A 124
 GPJ  A 429 ( 4.7A)
None
None
None
GPJ  A 429 (-3.0A)
 1.44A 3hamA-3nvsA:
0.0		 3hamA-3nvsA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RGL_A_GLYA301_0
(GLYCYL-TRNA
SYNTHETASE ALPHA
SUBUNIT)		 3nvs 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE
(Vibrio
cholerae) 		4 / 8 ALA A  95
GLY A  96
THR A  97
GLN A 172
 None
GPJ  A 429 (-3.2A)
GPJ  A 429 ( 4.0A)
GPJ  A 429 (-3.0A)
 0.89A 3rglA-3nvsA:
undetectable		 3rglA-3nvsA:
26.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KTT_A_SAMA405_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 3nvs 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE
(Vibrio
cholerae) 		4 / 8 HIS A 386
LYS A 412
SER A  25
ASP A 314
 GPJ  A 429 (-4.3A)
GPJ  A 429 (-2.9A)
None
SKM  A 428 (-2.7A)
 1.08A 4kttA-3nvsA:
undetectable		 4kttA-3nvsA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KTT_C_SAMC404_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 3nvs 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE
(Vibrio
cholerae) 		4 / 8 HIS A 386
LYS A 412
SER A  25
ASP A 314
 GPJ  A 429 (-4.3A)
GPJ  A 429 (-2.9A)
None
SKM  A 428 (-2.7A)
 1.05A 4kttC-3nvsA:
undetectable		 4kttC-3nvsA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NDN_A_SAMA407_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 3nvs 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE
(Vibrio
cholerae) 		4 / 8 HIS A 386
LYS A 412
SER A  25
ASP A 314
 GPJ  A 429 (-4.3A)
GPJ  A 429 (-2.9A)
None
SKM  A 428 (-2.7A)
 1.05A 4ndnA-3nvsA:
undetectable		 4ndnA-3nvsA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NDN_C_SAMC405_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 3nvs 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE
(Vibrio
cholerae) 		4 / 7 HIS A 386
LYS A 412
SER A  25
ASP A 314
 GPJ  A 429 (-4.3A)
GPJ  A 429 (-2.9A)
None
SKM  A 428 (-2.7A)
 1.03A 4ndnC-3nvsA:
undetectable		 4ndnC-3nvsA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODJ_A_SAMA500_0
(S-ADENOSYLMETHIONINE
SYNTHASE)		 3nvs 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE
(Vibrio
cholerae) 		4 / 7 HIS A 386
LYS A 412
SER A  25
ASP A 314
 GPJ  A 429 (-4.3A)
GPJ  A 429 (-2.9A)
None
SKM  A 428 (-2.7A)
 1.12A 4odjA-3nvsA:
undetectable		 4odjA-3nvsA:
24.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5I_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 3nvs 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE
(Vibrio
cholerae) 		3 / 3 ASP A  48
ARG A 345
ARG A 124
 None
GPJ  A 429 (-2.6A)
GPJ  A 429 (-3.0A)
 0.93A 4x5iA-3nvsA:
undetectable		 4x5iA-3nvsA:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A1I_A_ADNA407_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 3nvs 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE
(Vibrio
cholerae) 		4 / 8 HIS A 386
LYS A 412
SER A  25
ASP A 314
 GPJ  A 429 (-4.3A)
GPJ  A 429 (-2.9A)
None
SKM  A 428 (-2.7A)
 1.13A 5a1iA-3nvsA:
undetectable		 5a1iA-3nvsA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A1I_A_SAMA405_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 3nvs 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE
(Vibrio
cholerae) 		4 / 7 HIS A 386
LYS A 412
SER A  25
ASP A 314
 GPJ  A 429 (-4.3A)
GPJ  A 429 (-2.9A)
None
SKM  A 428 (-2.7A)
 1.13A 5a1iA-3nvsA:
undetectable		 5a1iA-3nvsA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EAJ_B_FOLB201_1
(DIHYDROFOLATE
REDUCTASE)		 3nvs 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE
(Vibrio
cholerae) 		3 / 3 ASP A  48
ARG A 345
ARG A 124
 None
GPJ  A 429 (-2.6A)
GPJ  A 429 (-3.0A)
 0.94A 5eajB-3nvsA:
undetectable		 5eajB-3nvsA:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HP1_C_PPFC601_1
(HIV-1 REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 3nvs 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE
(Vibrio
cholerae) 		4 / 6 ARG A 345
ASP A  49
GLY A  96
LYS A  22
 GPJ  A 429 (-2.6A)
GPJ  A 429 ( 4.7A)
GPJ  A 429 (-3.2A)
S3P  A 427 (-2.6A)
 1.09A 5hp1C-3nvsA:
undetectable		 5hp1C-3nvsA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FBN_B_SAMB401_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 3nvs 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE
(Vibrio
cholerae) 		4 / 8 HIS A 386
LYS A 412
SER A  25
ASP A 314
 GPJ  A 429 (-4.3A)
GPJ  A 429 (-2.9A)
None
SKM  A 428 (-2.7A)
 1.06A 6fbnB-3nvsA:
undetectable		 6fbnB-3nvsA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FBO_A_ADNA406_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 3nvs 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE
(Vibrio
cholerae) 		4 / 8 HIS A 386
LYS A 412
SER A  25
ASP A 314
 GPJ  A 429 (-4.3A)
GPJ  A 429 (-2.9A)
None
SKM  A 428 (-2.7A)
 1.14A 6fboA-3nvsA:
undetectable		 6fboA-3nvsA:
10.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FCB_A_SAMA405_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 3nvs 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE
(Vibrio
cholerae) 		4 / 8 HIS A 386
LYS A 412
SER A  25
ASP A 314
 GPJ  A 429 (-4.3A)
GPJ  A 429 (-2.9A)
None
SKM  A 428 (-2.7A)
 1.08A 6fcbA-3nvsA:
undetectable		 6fcbA-3nvsA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FCD_A_ADNA405_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 3nvs 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE
(Vibrio
cholerae) 		4 / 8 HIS A 386
LYS A 412
SER A  25
ASP A 314
 GPJ  A 429 (-4.3A)
GPJ  A 429 (-2.9A)
None
SKM  A 428 (-2.7A)
 1.14A 6fcdA-3nvsA:
undetectable		 6fcdA-3nvsA:
10.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G6R_A_SAMA406_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 3nvs 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE
(Vibrio
cholerae) 		4 / 7 HIS A 386
LYS A 412
SER A  25
ASP A 314
 GPJ  A 429 (-4.3A)
GPJ  A 429 (-2.9A)
None
SKM  A 428 (-2.7A)
 1.13A 6g6rA-3nvsA:
undetectable		 6g6rA-3nvsA:
21.53