SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'GPE'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1C4D_D_DVAD8_0 (GRAMICIDIN A)	5t1p	ABC TRANSPORTER, PERIPLASMIC SUBSTRATE-BINDING PROTEIN (Campylobacter jejuni)	3 / 3	TRP A 48 VAL A 91 TRP A 45	None None GPE A 402 (-3.2A)	1.16A	1c4dC-5t1pA: undetectable 1c4dD-5t1pA: undetectable	1c4dC-5t1pA: 5.60 1c4dD-5t1pA: 5.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1KIA_D_SAMD3293_1 (GLYCINE N-METHYLTRANSFERASE)	5t1p	ABC TRANSPORTER, PERIPLASMIC SUBSTRATE-BINDING PROTEIN (Campylobacter jejuni)	4 / 5	TRP A 339 ILE A 344 ASP A 210 ASN A 230	None None GPE A 402 (-3.7A) None	1.47A	1kiaD-5t1pA: undetectable	1kiaD-5t1pA: 23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3UJ6_A_SAMA300_1 (PHOSPHOETHANOLAMINE N-METHYLTRANSFERASE)	5t1p	ABC TRANSPORTER, PERIPLASMIC SUBSTRATE-BINDING PROTEIN (Campylobacter jejuni)	4 / 4	SER A 255 ASP A 90 ASP A 67 ALA A 170	None None GPE A 402 ( 4.5A) GPE A 402 (-3.6A)	1.40A	3uj6A-5t1pA: undetectable	3uj6A-5t1pA: 22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4LNW_A_T3A502_1 (THYROID HORMONE RECEPTOR ALPHA)	5t1p	ABC TRANSPORTER, PERIPLASMIC SUBSTRATE-BINDING PROTEIN (Campylobacter jejuni)	4 / 8	SER A 38 ASP A 65 GLU A 73 THR A 51	None None GPE A 402 ( 4.6A) None	1.10A	4lnwA-5t1pA: undetectable	4lnwA-5t1pA: 22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4MWZ_A_SAMA301_1 (PHOSPHOETHANOLAMINE N-METHYLTRANSFERASE, PUTATIVE)	5t1p	ABC TRANSPORTER, PERIPLASMIC SUBSTRATE-BINDING PROTEIN (Campylobacter jejuni)	3 / 3	SER A 255 ASP A 90 ASP A 67	None None GPE A 402 ( 4.5A)	0.92A	4mwzA-5t1pA: undetectable	4mwzA-5t1pA: 24.36

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1C4D_D_DVAD8_0","GRAMICIDIN A","5t1p","ABC TRANSPORTER, PERIPLASMIC SUBSTRATE-BINDING PROTEIN","Campylobacter jejuni",3,"TRP A  48;VAL A  91;TRP A  45","None;None;GPE A 402 (-3.2A)","1.16A","1c4dC-5t1pA:undetectable;1c4dD-5t1pA:undetectable",null],["1KIA_D_SAMD3293_1","GLYCINE N-METHYLTRANSFERASE","5t1p","ABC TRANSPORTER, PERIPLASMIC SUBSTRATE-BINDING PROTEIN","Campylobacter jejuni",4,"TRP A 339;ILE A 344;ASP A 210;ASN A 230","None;None;GPE A 402 (-3.7A);None","1.47A","1kiaD-5t1pA:undetectable","1c4dC-5t1pA:5.60;1c4dD-5t1pA:5.60"],["3UJ6_A_SAMA300_1","PHOSPHOETHANOLAMINE N-METHYLTRANSFERASE","5t1p","ABC TRANSPORTER, PERIPLASMIC SUBSTRATE-BINDING PROTEIN","Campylobacter jejuni",4,"SER A 255;ASP A  90;ASP A  67;ALA A 170","None;None;GPE A 402 ( 4.5A);GPE A 402 (-3.6A)","1.40A","3uj6A-5t1pA:undetectable","1kiaD-5t1pA:23.10"],["4LNW_A_T3A502_1","THYROID HORMONE RECEPTOR ALPHA","5t1p","ABC TRANSPORTER, PERIPLASMIC SUBSTRATE-BINDING PROTEIN","Campylobacter jejuni",4,"SER A  38;ASP A  65;GLU A  73;THR A  51","None;None;GPE A 402 ( 4.6A);None","1.10A","4lnwA-5t1pA:undetectable","3uj6A-5t1pA:22.86"],["4MWZ_A_SAMA301_1","PHOSPHOETHANOLAMINE N-METHYLTRANSFERASE, PUTATIVE","5t1p","ABC TRANSPORTER, PERIPLASMIC SUBSTRATE-BINDING PROTEIN","Campylobacter jejuni",3,"SER A 255;ASP A  90;ASP A  67","None;None;GPE A 402 ( 4.5A)","0.92A","4mwzA-5t1pA:undetectable","4lnwA-5t1pA:22.79"]]