SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'GP7'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_A_STIA600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3k7t 6-HYDROXY-L-NICOTINE
OXIDASE
(Paenarthrobacter
nicotinovorans) 		4 / 6 LEU A 168
VAL A 111
VAL A 147
ILE A 191
 None
None
None
GP7  A 435 (-4.6A)
 0.97A 2hyyA-3k7tA:
undetectable		 2hyyA-3k7tA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8R_C_MMSC516_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		 3k7t 6-HYDROXY-L-NICOTINE
OXIDASE
(Paenarthrobacter
nicotinovorans) 		4 / 8 HIS A 187
GLY A 193
VAL A 195
SER A 197
 None
None
GP7  A 435 (-4.7A)
None
 0.89A 5m8rC-3k7tA:
undetectable		 5m8rC-3k7tA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC3_A_486A801_2
(GLUCOCORTICOID
RECEPTOR)		 3k7t 6-HYDROXY-L-NICOTINE
OXIDASE
(Paenarthrobacter
nicotinovorans) 		4 / 5 LEU A 196
LEU A 192
MET A 167
TYR A  59
 GP7  A 435 ( 4.8A)
GP7  A 435 (-4.5A)
None
None
 0.84A 5uc3A-3k7tA:
undetectable		 5uc3A-3k7tA:
11.35