SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'GP2'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T3R_A_017A1200_1
(PROTEASE RETROPEPSIN)		 1s1d APYRASE
(Homo
sapiens) 		5 / 10 GLY A 157
ALA A 144
ASP A 112
ILE A 101
VAL A 129
 None
None
GP2  A4001 (-4.2A)
TRS  A5001 ( 4.9A)
None
 0.85A 1t3rA-1s1dA:
undetectable		 1t3rA-1s1dA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R5Q_B_1UNB900_2
(PROTEASE)		 1s1d APYRASE
(Homo
sapiens) 		5 / 11 GLY A 157
ALA A 144
ASP A 112
ILE A 101
VAL A 129
 None
None
GP2  A4001 (-4.2A)
TRS  A5001 ( 4.9A)
None
 0.89A 2r5qB-1s1dA:
undetectable		 2r5qB-1s1dA:
14.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BVB_B_017B401_2
(PROTEASE
(RETROPEPSIN))		 1s1d APYRASE
(Homo
sapiens) 		5 / 12 GLY A 157
ALA A 144
ASP A 112
ILE A 101
VAL A 129
 None
None
GP2  A4001 (-4.2A)
TRS  A5001 ( 4.9A)
None
 0.83A 3bvbB-1s1dA:
undetectable		 3bvbB-1s1dA:
12.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BXO_A_SAMA238_1
(N,N-DIMETHYLTRANSFER
ASE)		 1s1d APYRASE
(Homo
sapiens) 		3 / 3 TYR A 237
GLU A 145
ASP A 111
 GP2  A4001 (-4.2A)
GP2  A4001 ( 2.7A)
None
 0.83A 3bxoA-1s1dA:
undetectable		 3bxoA-1s1dA:
25.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BXO_B_SAMB238_1
(N,N-DIMETHYLTRANSFER
ASE)		 1s1d APYRASE
(Homo
sapiens) 		3 / 3 TYR A 237
GLU A 145
ASP A 111
 GP2  A4001 (-4.2A)
GP2  A4001 ( 2.7A)
None
 0.82A 3bxoB-1s1dA:
undetectable		 3bxoB-1s1dA:
25.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_B_ROCB201_3
(HIV-1 PROTEASE)		 1s1d APYRASE
(Homo
sapiens) 		5 / 12 GLY A 157
ALA A 144
ASP A 112
ILE A 101
VAL A 129
 None
None
GP2  A4001 (-4.2A)
TRS  A5001 ( 4.9A)
None
 0.86A 3k4vB-1s1dA:
undetectable		 3k4vB-1s1dA:
11.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDT_A_ROCA101_3
(PROTEASE)		 1s1d APYRASE
(Homo
sapiens) 		5 / 12 GLY A 157
ALA A 144
ASP A 112
ILE A 101
VAL A 129
 None
None
GP2  A4001 (-4.2A)
TRS  A5001 ( 4.9A)
None
 0.88A 3ndtB-1s1dA:
undetectable		 3ndtB-1s1dA:
11.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OY4_B_017B200_2
(HIV-1 PROTEASE)		 1s1d APYRASE
(Homo
sapiens) 		5 / 10 GLY A 157
ALA A 144
ASP A 112
ILE A 101
VAL A 129
 None
None
GP2  A4001 (-4.2A)
TRS  A5001 ( 4.9A)
None
 0.89A 3oy4B-1s1dA:
undetectable		 3oy4B-1s1dA:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKW_B_017B401_2
(PROTEASE)		 1s1d APYRASE
(Homo
sapiens) 		5 / 12 GLY A 157
ALA A 144
ASP A 112
ILE A 101
VAL A 129
 None
None
GP2  A4001 (-4.2A)
TRS  A5001 ( 4.9A)
None
 0.86A 3tkwB-1s1dA:
undetectable		 3tkwB-1s1dA:
12.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TL9_A_ROCA401_1
(PROTEASE)		 1s1d APYRASE
(Homo
sapiens) 		5 / 12 GLY A 157
ALA A 144
ASP A 112
ILE A 101
VAL A 129
 None
None
GP2  A4001 (-4.2A)
TRS  A5001 ( 4.9A)
None
 0.85A 3tl9A-1s1dA:
undetectable		 3tl9A-1s1dA:
12.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQB_B_017B101_2
(ASPARTYL PROTEASE)		 1s1d APYRASE
(Homo
sapiens) 		5 / 10 GLY A 157
ALA A 144
ASP A 112
ILE A 101
VAL A 129
 None
None
GP2  A4001 (-4.2A)
TRS  A5001 ( 4.9A)
None
 0.87A 4dqbB-1s1dA:
undetectable		 4dqbB-1s1dA:
16.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQE_B_017B101_2
(ASPARTYL PROTEASE)		 1s1d APYRASE
(Homo
sapiens) 		5 / 10 GLY A 157
ALA A 144
ASP A 112
ILE A 101
VAL A 129
 None
None
GP2  A4001 (-4.2A)
TRS  A5001 ( 4.9A)
None
 0.86A 4dqeB-1s1dA:
undetectable		 4dqeB-1s1dA:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQF_B_017B101_2
(ASPARTYL PROTEASE)		 1s1d APYRASE
(Homo
sapiens) 		5 / 10 GLY A 157
ALA A 144
ASP A 112
ILE A 101
VAL A 129
 None
None
GP2  A4001 (-4.2A)
TRS  A5001 ( 4.9A)
None
 0.89A 4dqfB-1s1dA:
undetectable		 4dqfB-1s1dA:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQH_B_017B101_2
(WILD-TYPE HIV-1
PROTEASE DIMER)		 1s1d APYRASE
(Homo
sapiens) 		5 / 10 GLY A 157
ALA A 144
ASP A 112
ILE A 101
VAL A 129
 None
None
GP2  A4001 (-4.2A)
TRS  A5001 ( 4.9A)
None
 0.84A 4dqhB-1s1dA:
undetectable		 4dqhB-1s1dA:
15.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EBK_A_TOYA301_1
(AMINOGLYCOSIDE
NUCLEOTIDYLTRANSFERA
SE)		 1s1d APYRASE
(Homo
sapiens) 		5 / 9 GLU A 243
GLU A 295
GLU A 326
ASP A 112
GLU A 239
 None
None
GP2  A4001 ( 2.4A)
GP2  A4001 (-4.2A)
None
 1.40A 4ebkA-1s1dA:
0.0
4ebkB-1s1dA:
0.0		 4ebkA-1s1dA:
23.16
4ebkB-1s1dA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNW_A_T3A502_1
(THYROID HORMONE
RECEPTOR ALPHA)		 1s1d APYRASE
(Homo
sapiens) 		4 / 8 SER A  98
ASP A 112
GLU A 214
THR A  45
 GP2  A4001 (-4.8A)
GP2  A4001 (-4.2A)
CA  A1001 (-4.0A)
None
 0.80A 4lnwA-1s1dA:
undetectable		 4lnwA-1s1dA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NTX_A_AMRA509_1
(ACID-SENSING ION
CHANNEL 1
BASIC PHOSPHOLIPASE
A2 HOMOLOG TX-BETA)		 1s1d APYRASE
(Homo
sapiens) 		4 / 6 ASP A  42
ASP A 112
GLU A 145
ARG A  93
 GP2  A4001 (-3.7A)
GP2  A4001 (-4.2A)
GP2  A4001 ( 2.7A)
None
 1.41A 4ntxA-1s1dA:
0.0
4ntxC-1s1dA:
undetectable		 4ntxA-1s1dA:
20.94
4ntxC-1s1dA:
14.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NTX_A_AMRA509_1
(ACID-SENSING ION
CHANNEL 1
BASIC PHOSPHOLIPASE
A2 HOMOLOG TX-BETA)		 1s1d APYRASE
(Homo
sapiens) 		4 / 6 GLU A 295
ASP A  42
ASP A 112
GLU A 145
 None
GP2  A4001 (-3.7A)
GP2  A4001 (-4.2A)
GP2  A4001 ( 2.7A)
 1.31A 4ntxA-1s1dA:
0.0
4ntxC-1s1dA:
undetectable		 4ntxA-1s1dA:
20.94
4ntxC-1s1dA:
14.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q1W_A_017A104_1
(ASPARTYL PROTEASE)		 1s1d APYRASE
(Homo
sapiens) 		5 / 9 GLY A 157
ALA A 144
ASP A 112
ILE A 101
VAL A 129
 None
None
GP2  A4001 (-4.2A)
TRS  A5001 ( 4.9A)
None
 0.89A 4q1wA-1s1dA:
undetectable		 4q1wA-1s1dA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q1X_A_017A101_1
(ASPARTYL PROTEASE)		 1s1d APYRASE
(Homo
sapiens) 		5 / 11 GLY A 157
ALA A 144
ASP A 112
ILE A 101
VAL A 129
 None
None
GP2  A4001 (-4.2A)
TRS  A5001 ( 4.9A)
None
 0.87A 4q1xA-1s1dA:
undetectable		 4q1xA-1s1dA:
16.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q1Y_A_017A106_1
(ASPARTYL PROTEASE)		 1s1d APYRASE
(Homo
sapiens) 		5 / 10 GLY A 157
ALA A 144
ASP A 112
ILE A 101
VAL A 129
 None
None
GP2  A4001 (-4.2A)
TRS  A5001 ( 4.9A)
None
 0.89A 4q1yA-1s1dA:
undetectable		 4q1yA-1s1dA:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QGI_A_ROCA101_1
(PROTEASE)		 1s1d APYRASE
(Homo
sapiens) 		5 / 11 GLY A 157
ALA A 144
ASP A 112
ILE A 101
VAL A 129
 None
None
GP2  A4001 (-4.2A)
TRS  A5001 ( 4.9A)
None
 0.94A 4qgiA-1s1dA:
undetectable		 4qgiA-1s1dA:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_H_SAMH301_1
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 1s1d APYRASE
(Homo
sapiens) 		4 / 5 THR A 114
GLY A 141
GLU A 145
ASP A 111
 None
None
GP2  A4001 ( 2.7A)
None
 0.97A 5c0oH-1s1dA:
undetectable		 5c0oH-1s1dA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR0_A_478A101_2
(PROTEASE E35D-APV)		 1s1d APYRASE
(Homo
sapiens) 		5 / 9 GLY A 157
ALA A 144
ASP A 112
ILE A 101
VAL A 129
 None
None
GP2  A4001 (-4.2A)
TRS  A5001 ( 4.9A)
None
 0.81A 5kr0B-1s1dA:
undetectable		 5kr0B-1s1dA:
12.79