SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'GOA'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2IJ7_C_TPFC2471_1 (CYTOCHROME P450 121)	3if9	GLYCINE OXIDASE (Bacillus subtilis)	4 / 8	THR A 239 VAL A 248 VAL A 257 ARG A 329	None None None GOA A 370 ( 3.1A)	1.17A	2ij7C-3if9A: undetectable	2ij7C-3if9A: 23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3BSZ_E_RTLE177_0 (PLASMA RETINOL-BINDING PROTEIN)	4zwo	ORGANOPHOSPHATE ANHYDROLASE/PROLIDAS E (Alteromonas sp.)	5 / 11	ALA A 253 ALA A 254 LEU A 439 HIS A 336 PHE A 212	None None None MN A 501 ( 3.5A) GOA A 506 (-3.5A)	1.23A	3bszE-4zwoA: undetectable	3bszE-4zwoA: 17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3K37_A_BCZA468_1 (NEURAMINIDASE)	5tws	HUMAN DNA POLYMERASE MU (Homo sapiens)	3 / 3	ASP A 330 ARG A 416 ARG A 323	MG A 501 (-2.6A) NA A 502 ( 4.9A) GOA A 503 (-3.0A)	1.01A	3k37A-5twsA: undetectable	3k37A-5twsA: 20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3NAI_C_URFC521_1 (RNA DEPENDENT RNA POLYMERASE)	5tws	HUMAN DNA POLYMERASE MU (Homo sapiens)	4 / 5	ARG A 323 ASP A 330 ASP A 332 ASP A 418	GOA A 503 (-3.0A) MG A 501 (-2.6A) NA A 502 (-2.5A) NA A 502 (-3.1A)	1.47A	3naiC-5twsA: 1.8	3naiC-5twsA: 22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3OU6_C_SAMC300_0 (SAM-DEPENDENT METHYLTRANSFERASE)	3if9	GLYCINE OXIDASE (Bacillus subtilis)	5 / 12	LEU A 220 GLU A 225 GLY A 264 LEU A 301 ALA A 259	None None None None GOA A 370 ( 4.0A)	1.20A	3ou6C-3if9A: 2.9	3ou6C-3if9A: 22.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4YSH_B_GLYB402_0 (GLYCINE OXIDASE)	3if9	GLYCINE OXIDASE (Bacillus subtilis)	4 / 5	MET A 49 TYR A 246 ARG A 302 ARG A 329	FAD A 371 (-4.4A) GOA A 370 ( 4.5A) GOA A 370 ( 4.0A) GOA A 370 ( 3.1A)	0.51A	4yshB-3if9A: 52.7	4yshB-3if9A: 38.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5Z6J_A_FOLA201_1 (DIHYDROFOLATE REDUCTASE)	3if9	GLYCINE OXIDASE (Bacillus subtilis)	3 / 3	MET A 111 ASP A 145 ARG A 329	None None GOA A 370 ( 3.1A)	0.93A	5z6jA-3if9A: undetectable	5z6jA-3if9A: 18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5Z6K_A_FOLA201_1 (DIHYDROFOLATE REDUCTASE)	3if9	GLYCINE OXIDASE (Bacillus subtilis)	3 / 3	MET A 111 ASP A 145 ARG A 329	None None GOA A 370 ( 3.1A)	1.16A	5z6kA-3if9A: undetectable	5z6kA-3if9A: 18.62

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["2IJ7_C_TPFC2471_1","CYTOCHROME P450 121","3if9","GLYCINE OXIDASE","Bacillus subtilis",4,"THR A 239;VAL A 248;VAL A 257;ARG A 329","None;None;None;GOA A 370 ( 3.1A)","1.17A","2ij7C-3if9A:undetectable",null],["3BSZ_E_RTLE177_0","PLASMA RETINOL-BINDING PROTEIN","4zwo","ORGANOPHOSPHATE ANHYDROLASE\/PROLIDASE","Alteromonas sp.",5,"ALA A 253;ALA A 254;LEU A 439;HIS A 336;PHE A 212","None;None;None; MN A 501 ( 3.5A);GOA A 506 (-3.5A)","1.23A","3bszE-4zwoA:undetectable","2ij7C-3if9A:23.13"],["3K37_A_BCZA468_1","NEURAMINIDASE","5tws","HUMAN DNA POLYMERASE MU","Homo sapiens",3,"ASP A 330;ARG A 416;ARG A 323"," MG A 501 (-2.6A); NA A 502 ( 4.9A);GOA A 503 (-3.0A)","1.01A","3k37A-5twsA:undetectable","3bszE-4zwoA:17.63"],["3NAI_C_URFC521_1","RNA DEPENDENT RNA POLYMERASE","5tws","HUMAN DNA POLYMERASE MU","Homo sapiens",4,"ARG A 323;ASP A 330;ASP A 332;ASP A 418","GOA A 503 (-3.0A); MG A 501 (-2.6A); NA A 502 (-2.5A); NA A 502 (-3.1A)","1.47A","3naiC-5twsA:1.8","3k37A-5twsA:20.15"],["3OU6_C_SAMC300_0","SAM-DEPENDENT METHYLTRANSFERASE","3if9","GLYCINE OXIDASE","Bacillus subtilis",5,"LEU A 220;GLU A 225;GLY A 264;LEU A 301;ALA A 259","None;None;None;None;GOA A 370 ( 4.0A)","1.20A","3ou6C-3if9A:2.9","3naiC-5twsA:22.22"],["4YSH_B_GLYB402_0","GLYCINE OXIDASE","3if9","GLYCINE OXIDASE","Bacillus subtilis",4,"MET A  49;TYR A 246;ARG A 302;ARG A 329","FAD A 371 (-4.4A);GOA A 370 ( 4.5A);GOA A 370 ( 4.0A);GOA A 370 ( 3.1A)","0.51A","4yshB-3if9A:52.7","3ou6C-3if9A:22.19"],["5Z6J_A_FOLA201_1","DIHYDROFOLATE REDUCTASE","3if9","GLYCINE OXIDASE","Bacillus subtilis",3,"MET A 111;ASP A 145;ARG A 329","None;None;GOA A 370 ( 3.1A)","0.93A","5z6jA-3if9A:undetectable","4yshB-3if9A:38.52"],["5Z6K_A_FOLA201_1","DIHYDROFOLATE REDUCTASE","3if9","GLYCINE OXIDASE","Bacillus subtilis",3,"MET A 111;ASP A 145;ARG A 329","None;None;GOA A 370 ( 3.1A)","1.16A","5z6kA-3if9A:undetectable","5z6jA-3if9A:18.62"]]