SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'GNP'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_B_DCFB853_2
(ADENOSINE DEAMINASE)		 1wf3 GTP-BINDING PROTEIN
(Thermus
thermophilus) 		4 / 5 HIS A  98
SER A 153
LEU A 155
GLY A  19
 None
GNP  A 501 (-2.7A)
GNP  A 501 ( 4.4A)
GNP  A 501 (-3.4A)
 1.09A 1a4lB-1wf3A:
undetectable		 1a4lB-1wf3A:
24.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AQ7_B_AG2B4_1
(TRYPSIN
AERUGINOSIN 98-B)		 3zjc GTPASE IMAP FAMILY
MEMBER 7
(Homo
sapiens) 		4 / 8 SER A  19
SER A  22
GLY A  66
GLY A  15
 GNP  A1297 (-3.9A)
MG  A1296 ( 2.4A)
GNP  A1297 ( 4.3A)
None
 0.68A 1aq7A-3zjcA:
undetectable		 1aq7A-3zjcA:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7A_A_PFLA4002_1
(SERUM ALBUMIN)		 1huq RAB5C
(Mus
musculus) 		3 / 3 PHE A  46
LEU A  37
SER A 164
 GNP  A 200 (-4.1A)
None
GNP  A 200 (-3.5A)
 0.78A 1e7aA-1huqA:
undetectable		 1e7aA-1huqA:
14.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7A_A_PFLA4002_1
(SERUM ALBUMIN)		 1x1s RAS-RELATED PROTEIN
M-RAS
(Mus
musculus) 		3 / 3 PHE A  38
LEU A  29
SER A 156
 GNP  A 179 (-4.2A)
None
GNP  A 179 (-3.6A)
 0.72A 1e7aA-1x1sA:
1.0		 1e7aA-1x1sA:
15.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7A_A_PFLA4002_1
(SERUM ALBUMIN)		 1x3s RAS-RELATED PROTEIN
RAB-18
(Homo
sapiens) 		3 / 3 PHE A  33
LEU A  24
SER A 151
 GNP  A 300 (-4.1A)
None
GNP  A 300 (-3.4A)
 0.70A 1e7aA-1x3sA:
undetectable		 1e7aA-1x3sA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7A_A_PFLA4002_1
(SERUM ALBUMIN)		 1z06 RAS-RELATED PROTEIN
RAB-33B
(Mus
musculus) 		3 / 3 PHE A  58
LEU A  49
SER A 178
 GNP  A 204 (-4.6A)
None
GNP  A 204 (-3.2A)
 0.73A 1e7aA-1z06A:
undetectable		 1e7aA-1z06A:
14.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7A_A_PFLA4002_1
(SERUM ALBUMIN)		 2ocb RAS-RELATED PROTEIN
RAB-9B
(Homo
sapiens) 		3 / 3 PHE A  32
LEU A  23
SER A 154
 GNP  A 201 (-4.2A)
None
GNP  A 201 (-3.5A)
 0.81A 1e7aA-2ocbA:
undetectable		 1e7aA-2ocbA:
16.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7A_A_PFLA4002_1
(SERUM ALBUMIN)		 3oes GTPASE RHEBL1
(Homo
sapiens) 		3 / 3 PHE A  31
LEU A  22
SER A 149
 GNP  A 201 (-4.3A)
None
GNP  A 201 (-3.6A)
 0.70A 1e7aA-3oesA:
undetectable		 1e7aA-3oesA:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7A_A_PFLA4002_1
(SERUM ALBUMIN)		 5wdr RAS PROTEIN
(Choanoflagellida) 		3 / 3 PHE A  28
LEU A  19
SER A 146
 GNP  A 203 (-4.3A)
None
GNP  A 203 (-3.5A)
 0.74A 1e7aA-5wdrA:
undetectable		 1e7aA-5wdrA:
13.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7A_A_PFLA4002_1
(SERUM ALBUMIN)		 5xr6 RAS-RELATED PROTEIN
RABA1A
(Arabidopsis
thaliana) 		3 / 3 PHE A  38
LEU A  29
SER A 156
 GNP  A 301 (-4.8A)
None
GNP  A 301 (-3.3A)
 0.68A 1e7aA-5xr6A:
undetectable		 1e7aA-5xr6A:
8.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7A_A_PFLA4002_1
(SERUM ALBUMIN)		 6f76 -
(-) 		3 / 3 PHE B  28
LEU B  19
SER B 145
 GNP  B 202 (-4.3A)
None
GNP  B 202 (-3.6A)
 0.74A 1e7aA-6f76B:
undetectable		 1e7aA-6f76B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7B_A_HLTA4003_1
(SERUM ALBUMIN)		 3bh6 ADP-RIBOSYLATION
FACTOR-LIKE PROTEIN
3
(Mus
musculus) 		5 / 9 LEU A 122
VAL A 166
GLY A 165
ALA A 160
LEU A  33
 None
None
None
GNP  A   1 (-3.7A)
None
 0.97A 1e7bA-3bh6A:
undetectable		 1e7bA-3bh6A:
13.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_A_ACTA3003_0
(BETA-CARBONIC
ANHYDRASE)		 2rex RHO-RELATED
GTP-BINDING PROTEIN
RHO6
(Homo
sapiens) 		4 / 8 CYH B  24
ASP B  93
CYH B 125
GLY B 124
 GNP  B 500 (-3.9A)
None
UNX  B 554 ( 4.2A)
None
 0.98A 1ekjA-2rexB:
undetectable
1ekjB-2rexB:
3.0		 1ekjA-2rexB:
19.74
1ekjB-2rexB:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ESW_A_ACRA652_1
(AMYLOMALTASE)		 1f5n INTERFERON-INDUCED
GUANYLATE-BINDING
PROTEIN 1
(Homo
sapiens) 		4 / 6 GLY A  68
GLY A 100
TYR A  47
SER A  66
 GNP  A 593 (-3.8A)
GNP  A 593 (-3.1A)
None
None
 0.99A 1eswA-1f5nA:
undetectable		 1eswA-1f5nA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1F5L_A_AMRA301_1
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 2q3f RAS-RELATED
GTP-BINDING PROTEIN
D
(Homo
sapiens) 		4 / 8 SER A  54
SER A  57
GLY A 101
GLY A  50
 GNP  A 401 (-3.5A)
MG  A 301 ( 2.1A)
GNP  A 401 (-3.2A)
None
 0.69A 1f5lA-2q3fA:
undetectable		 1f5lA-2q3fA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1F5L_A_AMRA301_1
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 3r7w GTP-BINDING PROTEIN
GTR1
(Saccharomyces
cerevisiae) 		4 / 8 SER A  17
SER A  20
GLY A  64
GLY A  13
 GNP  A 500 (-3.6A)
MG  A 600 ( 2.0A)
GNP  A 500 (-3.8A)
None
 0.70A 1f5lA-3r7wA:
undetectable		 1f5lA-3r7wA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1F5L_A_AMRA301_1
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 3zjc GTPASE IMAP FAMILY
MEMBER 7
(Homo
sapiens) 		4 / 8 SER A  19
SER A  22
GLY A  66
GLY A  15
 GNP  A1297 (-3.9A)
MG  A1296 ( 2.4A)
GNP  A1297 ( 4.3A)
None
 0.65A 1f5lA-3zjcA:
undetectable		 1f5lA-3zjcA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FKO_A_EFZA999_1
(HIV-1 RT, A-CHAIN)		 3bc1 RAS-RELATED PROTEIN
RAB-27A
(Mus
musculus) 		5 / 10 ASN A 133
VAL A  20
VAL A  25
GLY A  21
LEU A  97
 GNP  A 195 (-3.2A)
GNP  A 195 ( 4.1A)
None
GNP  A 195 (-3.3A)
None
 1.34A 1fkoA-3bc1A:
undetectable		 1fkoA-3bc1A:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_C_TRPC81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 5l3s SIGNAL RECOGNITION
PARTICLE 54 KDA
PROTEIN
SIGNAL RECOGNITION
PARTICLE RECEPTOR
FTSY
(Sulfolobus
solfataricus;
Sulfolobus
acidocaldarius) 		5 / 10 ARG A 136
ALA B 215
GLY A 147
ALA B 214
THR A 110
 GNP  B 401 (-3.2A)
None
None
GOL  A 306 (-4.1A)
MG  A 302 ( 3.1A)
 1.22A 1gtnB-5l3sA:
undetectable
1gtnC-5l3sA:
undetectable		 1gtnB-5l3sA:
17.33
1gtnC-5l3sA:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_I_TRPI81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 5l3s SIGNAL RECOGNITION
PARTICLE 54 KDA
PROTEIN
SIGNAL RECOGNITION
PARTICLE RECEPTOR
FTSY
(Sulfolobus
solfataricus;
Sulfolobus
acidocaldarius) 		5 / 10 ARG A 136
ALA B 215
GLY A 147
ALA B 214
THR A 110
 GNP  B 401 (-3.2A)
None
None
GOL  A 306 (-4.1A)
MG  A 302 ( 3.1A)
 1.20A 1gtnH-5l3sA:
undetectable
1gtnI-5l3sA:
undetectable		 1gtnH-5l3sA:
17.33
1gtnI-5l3sA:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H1D_A_SAMA301_1
(CATECHOL-O-METHYLTRA
NSFERASE)		 5wdr RAS PROTEIN
(Choanoflagellida) 		4 / 4 SER A  89
GLU A 144
SER A 146
ASP A  85
 None
None
GNP  A 203 (-3.5A)
None
 1.38A 1h1dA-5wdrA:
2.8		 1h1dA-5wdrA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICV_D_NIOD706_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 3tjz ADP-RIBOSYLATION
FACTOR 1
(Saccharomyces
cerevisiae) 		4 / 5 GLU A 164
GLY A 165
SER A 162
THR A 161
 None
None
None
GNP  A 201 ( 4.0A)
 0.88A 1icvC-3tjzA:
undetectable
1icvD-3tjzA:
undetectable		 1icvC-3tjzA:
22.27
1icvD-3tjzA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JNO_A_DVAA6_0
(GRAMICIDIN A)		 2atx SMALL GTP BINDING
PROTEIN TC10
(Homo
sapiens) 		3 / 3 ALA A  73
VAL A  23
TRP A 111
 GNP  A 200 ( 4.4A)
None
None
 0.86A 1jnoA-2atxA:
undetectable		 1jnoA-2atxA:
5.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JNO_A_DVAA6_0
(GRAMICIDIN A)		 4u5x RAC-LIKE GTP-BINDING
PROTEIN 1
(Oryza
sativa) 		3 / 3 ALA A  66
VAL A  16
TRP A 104
 GNP  A 201 ( 4.5A)
None
None
 0.86A 1jnoA-4u5xA:
undetectable		 1jnoA-4u5xA:
12.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JNO_B_DVAB6_0
(GRAMICIDIN A)		 2atx SMALL GTP BINDING
PROTEIN TC10
(Homo
sapiens) 		3 / 3 ALA A  73
VAL A  23
TRP A 111
 GNP  A 200 ( 4.4A)
None
None
 0.86A 1jnoB-2atxA:
undetectable		 1jnoB-2atxA:
5.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JNO_B_DVAB6_0
(GRAMICIDIN A)		 4u5x RAC-LIKE GTP-BINDING
PROTEIN 1
(Oryza
sativa) 		3 / 3 ALA A  66
VAL A  16
TRP A 104
 GNP  A 201 ( 4.5A)
None
None
 0.86A 1jnoB-4u5xA:
undetectable		 1jnoB-4u5xA:
12.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M4I_A_KANA500_1
(AMINOGLYCOSIDE
2'-N-ACETYLTRANSFERA
SE)		 2rex RHO-RELATED
GTP-BINDING PROTEIN
RHO6
(Homo
sapiens) 		4 / 8 ASP B  93
GLY B 124
SER B 168
THR B 171
 None
None
GNP  B 500 (-3.6A)
None
 0.86A 1m4iA-2rexB:
undetectable		 1m4iA-2rexB:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MAG_A_DVAA6_0
(GRAMICIDIN A)		 2atx SMALL GTP BINDING
PROTEIN TC10
(Homo
sapiens) 		3 / 3 ALA A  73
VAL A  23
TRP A 111
 GNP  A 200 ( 4.4A)
None
None
 0.91A 1magA-2atxA:
undetectable		 1magA-2atxA:
5.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MAG_A_DVAA6_0
(GRAMICIDIN A)		 4u5x RAC-LIKE GTP-BINDING
PROTEIN 1
(Oryza
sativa) 		3 / 3 ALA A  66
VAL A  16
TRP A 104
 GNP  A 201 ( 4.5A)
None
None
 0.90A 1magA-4u5xA:
undetectable		 1magA-4u5xA:
12.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MAG_B_DVAB6_0
(GRAMICIDIN A)		 2atx SMALL GTP BINDING
PROTEIN TC10
(Homo
sapiens) 		3 / 3 ALA A  73
VAL A  23
TRP A 111
 GNP  A 200 ( 4.4A)
None
None
 0.91A 1magB-2atxA:
undetectable		 1magB-2atxA:
5.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MAG_B_DVAB6_0
(GRAMICIDIN A)		 4u5x RAC-LIKE GTP-BINDING
PROTEIN 1
(Oryza
sativa) 		3 / 3 ALA A  66
VAL A  16
TRP A 104
 GNP  A 201 ( 4.5A)
None
None
 0.90A 1magB-4u5xA:
undetectable		 1magB-4u5xA:
12.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MCB_P_DHIP3_0
(IMMUNOGLOBULIN
LAMBDA DIMER MCG
(LIGHT CHAIN)
PEPTIDE
N-ACETYL-L-GLN-D-PHE
-L-HIS-D-PRO-OH)		 6cey BIFUNCTIONAL AAC/APH
(Staphylococcus
aureus) 		4 / 5 TYR A 237
TYR A 244
GLU A 240
TYR A 274
 GNP  A 500 (-4.7A)
None
GNP  A 500 ( 4.4A)
GNP  A 500 (-4.7A)
 1.19A 1mcbA-6ceyA:
0.0
1mcbB-6ceyA:
0.0
1mcbP-6ceyA:
undetectable		 1mcbA-6ceyA:
undetectable
1mcbB-6ceyA:
undetectable
1mcbP-6ceyA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXD_A_ACRA732_1
(ALPHA AMYLASE)		 2j7p CELL DIVISION
PROTEIN FTSY
(Thermus
aquaticus) 		5 / 9 GLY D 112
GLY D 145
GLY D 146
ASP D 139
ARG D 142
 GNP  D1400 (-3.5A)
None
None
GNP  D1400 ( 4.7A)
GNP  D1400 ( 3.9A)
 1.19A 1mxdA-2j7pD:
3.5		 1mxdA-2j7pD:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXD_A_ACRA732_1
(ALPHA AMYLASE)		 2j7p CELL DIVISION
PROTEIN FTSY
(Thermus
aquaticus) 		5 / 9 GLY D 112
LYS D 256
GLY D 145
ASP D 139
ARG D 142
 GNP  D1400 (-3.5A)
GNP  D1400 (-3.8A)
None
GNP  D1400 ( 4.7A)
GNP  D1400 ( 3.9A)
 1.18A 1mxdA-2j7pD:
3.5		 1mxdA-2j7pD:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_A_VDYA1002_1
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 4rkf RAS-RELATED PROTEIN
RAB-3
(Drosophila
melanogaster) 		4 / 4 ILE A 181
LEU A 178
VAL A 174
ALA A 165
 None
None
None
GNP  A 201 (-3.7A)
 0.95A 1mz9A-4rkfA:
undetectable		 1mz9A-4rkfA:
12.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N2X_A_SAMA401_0
(S-ADENOSYL-METHYLTRA
NSFERASE MRAW)		 1r4a ADP-RIBOSYLATION
FACTOR-LIKE PROTEIN
1
(Rattus
norvegicus) 		5 / 12 GLY A  24
GLU A 106
GLY A  70
VAL A 123
ARG A  99
 None
None
GNP  A1201 (-3.9A)
None
None
 1.23A 1n2xA-1r4aA:
4.2		 1n2xA-1r4aA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N2X_B_SAMB402_0
(S-ADENOSYL-METHYLTRA
NSFERASE MRAW)		 2j7p CELL DIVISION
PROTEIN FTSY
(Thermus
aquaticus) 		5 / 12 THR D 117
GLY D 114
GLY D 112
VAL D 227
GLY D 283
 GNP  D1400 (-3.6A)
GNP  D1400 (-3.1A)
GNP  D1400 (-3.5A)
None
GNP  D1400 (-3.4A)
 0.91A 1n2xB-2j7pD:
3.6		 1n2xB-2j7pD:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N2X_B_SAMB402_0
(S-ADENOSYL-METHYLTRA
NSFERASE MRAW)		 5l3q SIGNAL RECOGNITION
PARTICLE RECEPTOR
SUBUNIT ALPHA
(Homo
sapiens) 		5 / 12 THR B 433
GLY B 430
GLY B 428
VAL B 550
GLY B 617
 GNP  B 705 (-3.6A)
GNP  B 705 (-3.1A)
GNP  B 705 (-3.4A)
None
GNP  B 705 (-3.3A)
 0.96A 1n2xB-5l3qB:
3.6		 1n2xB-5l3qB:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NG8_A_DVAA6_0
(GRAMICIDIN A)		 2atx SMALL GTP BINDING
PROTEIN TC10
(Homo
sapiens) 		3 / 3 ALA A  73
VAL A  23
TRP A 111
 GNP  A 200 ( 4.4A)
None
None
 0.86A 1ng8A-2atxA:
undetectable		 1ng8A-2atxA:
5.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NG8_A_DVAA6_0
(GRAMICIDIN A)		 4u5x RAC-LIKE GTP-BINDING
PROTEIN 1
(Oryza
sativa) 		3 / 3 ALA A  66
VAL A  16
TRP A 104
 GNP  A 201 ( 4.5A)
None
None
 0.86A 1ng8A-4u5xA:
undetectable		 1ng8A-4u5xA:
16.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NG8_B_DVAB6_0
(GRAMICIDIN A)		 2atx SMALL GTP BINDING
PROTEIN TC10
(Homo
sapiens) 		3 / 3 ALA A  73
VAL A  23
TRP A 111
 GNP  A 200 ( 4.4A)
None
None
 0.86A 1ng8B-2atxA:
undetectable		 1ng8B-2atxA:
5.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NG8_B_DVAB6_0
(GRAMICIDIN A)		 4u5x RAC-LIKE GTP-BINDING
PROTEIN 1
(Oryza
sativa) 		3 / 3 ALA A  66
VAL A  16
TRP A 104
 GNP  A 201 ( 4.5A)
None
None
 0.86A 1ng8B-4u5xA:
undetectable		 1ng8B-4u5xA:
16.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NRU_A_DVAA6_0
(GRAMICIDIN A)		 2atx SMALL GTP BINDING
PROTEIN TC10
(Homo
sapiens) 		3 / 3 ALA A  73
VAL A  23
TRP A 111
 GNP  A 200 ( 4.4A)
None
None
 0.90A 1nruA-2atxA:
undetectable		 1nruA-2atxA:
5.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NRU_A_DVAA6_0
(GRAMICIDIN A)		 4u5x RAC-LIKE GTP-BINDING
PROTEIN 1
(Oryza
sativa) 		3 / 3 ALA A  66
VAL A  16
TRP A 104
 GNP  A 201 ( 4.5A)
None
None
 0.89A 1nruA-4u5xA:
undetectable		 1nruA-4u5xA:
12.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NRU_B_DVAB6_0
(GRAMICIDIN A)		 2atx SMALL GTP BINDING
PROTEIN TC10
(Homo
sapiens) 		3 / 3 ALA A  73
VAL A  23
TRP A 111
 GNP  A 200 ( 4.4A)
None
None
 0.90A 1nruB-2atxA:
undetectable		 1nruB-2atxA:
5.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NRU_B_DVAB6_0
(GRAMICIDIN A)		 4u5x RAC-LIKE GTP-BINDING
PROTEIN 1
(Oryza
sativa) 		3 / 3 ALA A  66
VAL A  16
TRP A 104
 GNP  A 201 ( 4.5A)
None
None
 0.89A 1nruB-4u5xA:
undetectable		 1nruB-4u5xA:
12.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P91_B_SAMB2401_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE A)		 5xkt UREASE ACCESSORY
PROTEIN UREG
(Klebsiella
pneumoniae) 		5 / 12 LEU A 110
GLY A  19
GLY A  17
ILE A 126
THR A 122
 None
GNP  A 301 (-3.3A)
GNP  A 301 (-3.3A)
None
None
 1.13A 1p91B-5xktA:
undetectable		 1p91B-5xktA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PWY_E_AC2E290_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 5l3q SIGNAL RECOGNITION
PARTICLE RECEPTOR
SUBUNIT ALPHA
(Homo
sapiens) 		5 / 10 GLY B 430
GLU B 552
VAL B 429
GLY B 428
THR B 433
 GNP  B 705 (-3.1A)
None
GNP  B 705 (-4.1A)
GNP  B 705 (-3.4A)
GNP  B 705 (-3.6A)
 1.24A 1pwyE-5l3qB:
undetectable		 1pwyE-5l3qB:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZF_D_FOLD617_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5cb2 PROTEIN SEY1
(Candida
albicans) 		5 / 12 VAL A  85
ASP A 123
LEU A  75
ILE A 266
THR A  95
 GNP  A 702 (-3.4A)
MG  A 701 ( 3.8A)
None
None
MG  A 701 ( 3.1A)
 1.15A 1qzfD-5cb2A:
undetectable		 1qzfD-5cb2A:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TKQ_B_DVAB6_0
(GRAMICIDIN A)		 4lbw ELONGATION FACTOR
TU-A
(Thermus
thermophilus) 		3 / 3 ALA A 175
VAL A 196
TRP A 200
 GNP  A 501 (-4.1A)
None
None
 0.81A 1tkqB-4lbwA:
undetectable		 1tkqB-4lbwA:
3.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TNL_A_TPAA900_1
(TRYPSIN)		 3zjc GTPASE IMAP FAMILY
MEMBER 7
(Homo
sapiens) 		4 / 6 SER A  19
SER A  22
GLY A  66
GLY A  15
 GNP  A1297 (-3.9A)
MG  A1296 ( 2.4A)
GNP  A1297 ( 4.3A)
None
 0.72A 1tnlA-3zjcA:
undetectable		 1tnlA-3zjcA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWJ_A_BAXA1723_2
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 4jr7 CASEIN KINASE II
SUBUNIT ALPHA
(Saccharomyces
cerevisiae) 		4 / 7 LYS A  69
LEU A  86
ILE A 133
ILE A 191
 GNP  A 401 (-3.3A)
None
None
None
 0.61A 1uwjA-4jr7A:
4.6		 1uwjA-4jr7A:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VID_A_SAMA301_1
(CATECHOL
O-METHYLTRANSFERASE)		 5wdr RAS PROTEIN
(Choanoflagellida) 		4 / 5 SER A  89
GLU A 144
SER A 146
ASP A  85
 None
None
GNP  A 203 (-3.5A)
None
 1.36A 1vidA-5wdrA:
3.0		 1vidA-5wdrA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOM_A_CIOA603_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 4jr7 CASEIN KINASE II
SUBUNIT ALPHA
(Saccharomyces
cerevisiae) 		5 / 12 HIS A 193
LEU A  86
ILE A 213
MET A 202
PHE A 152
 None
None
GNP  A 401 (-4.6A)
GNP  A 401 (-3.6A)
None
 1.46A 1xomA-4jr7A:
undetectable		 1xomA-4jr7A:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOM_B_CIOB601_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 4jr7 CASEIN KINASE II
SUBUNIT ALPHA
(Saccharomyces
cerevisiae) 		5 / 12 HIS A 193
LEU A  86
ILE A 213
MET A 202
PHE A 152
 None
None
GNP  A 401 (-4.6A)
GNP  A 401 (-3.6A)
None
 1.45A 1xomB-4jr7A:
undetectable		 1xomB-4jr7A:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZU_A_MTLA870_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 3qbt RAS-RELATED PROTEIN
RAB-8A
(Homo
sapiens) 		4 / 8 ASN A 126
GLN A 130
ASN A 121
ASP A  89
 None
None
GNP  A 200 (-3.5A)
None
 1.13A 1zzuA-3qbtA:
undetectable		 1zzuA-3qbtA:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AZX_A_TRPA601_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2y8e RAB-PROTEIN 6
(Drosophila
melanogaster) 		5 / 12 THR A  44
GLY A  19
GLN A  21
ILE A  45
PHE A  74
 MG  A1177 ( 3.1A)
None
GNP  A1176 (-4.8A)
None
None
 1.30A 2azxA-2y8eA:
undetectable		 2azxA-2y8eA:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AZX_B_TRPB603_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2y8e RAB-PROTEIN 6
(Drosophila
melanogaster) 		5 / 12 THR A  44
GLY A  19
GLN A  21
ILE A  45
PHE A  74
 MG  A1177 ( 3.1A)
None
GNP  A1176 (-4.8A)
None
None
 1.27A 2azxB-2y8eA:
undetectable		 2azxB-2y8eA:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B25_A_SAMA601_0
(HYPOTHETICAL PROTEIN)		 1r4a ADP-RIBOSYLATION
FACTOR-LIKE PROTEIN
1
(Rattus
norvegicus) 		5 / 12 THR A  48
GLY A  29
GLY A  27
GLY A  70
ASP A 129
 GNP  A1201 ( 3.6A)
GNP  A1201 (-3.1A)
GNP  A1201 (-3.7A)
GNP  A1201 (-3.9A)
GNP  A1201 (-3.0A)
 1.01A 2b25A-1r4aA:
2.9		 2b25A-1r4aA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B25_A_SAMA601_0
(HYPOTHETICAL PROTEIN)		 1x3s RAS-RELATED PROTEIN
RAB-18
(Homo
sapiens) 		5 / 12 THR A  40
GLY A  20
GLY A  18
GLY A  66
ASP A 125
 MG  A 200 ( 3.0A)
GNP  A 300 (-3.3A)
GNP  A 300 (-3.5A)
GNP  A 300 (-3.2A)
GNP  A 300 (-2.9A)
 1.01A 2b25A-1x3sA:
undetectable		 2b25A-1x3sA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B25_A_SAMA601_0
(HYPOTHETICAL PROTEIN)		 1yvd RAS-RELATED PROTEIN
RAB-22A
(Mus
musculus) 		5 / 12 THR A  37
GLY A  17
GLY A  15
GLY A  63
ASP A 121
 MG  A 850 ( 3.2A)
GNP  A 900 (-3.2A)
GNP  A 900 (-3.8A)
GNP  A 900 (-3.2A)
GNP  A 900 (-3.0A)
 1.04A 2b25A-1yvdA:
2.5		 2b25A-1yvdA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B25_A_SAMA601_0
(HYPOTHETICAL PROTEIN)		 1yzn GTP-BINDING PROTEIN
YPT1
(Saccharomyces
cerevisiae) 		5 / 12 THR A  40
GLY A  20
GLY A  18
GLY A  66
ASP A 124
 MG  A 301 ( 3.1A)
GNP  A 300 (-3.3A)
GNP  A 300 (-3.7A)
GNP  A 300 (-3.1A)
GNP  A 300 (-2.9A)
 1.02A 2b25A-1yznA:
2.5		 2b25A-1yznA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B25_A_SAMA601_0
(HYPOTHETICAL PROTEIN)		 1zc4 RAS-RELATED PROTEIN
RAL-A
(Homo
sapiens) 		5 / 12 THR A  46
GLY A  26
GLY A  24
GLY A  71
ASP A 130
 MG  A 200 ( 2.7A)
GNP  A 400 (-3.2A)
GNP  A 400 (-3.4A)
GNP  A 400 (-3.6A)
GNP  A 400 (-2.9A)
 1.01A 2b25A-1zc4A:
undetectable		 2b25A-1zc4A:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B25_A_SAMA601_0
(HYPOTHETICAL PROTEIN)		 2ew1 RAS-RELATED PROTEIN
RAB-30
(Homo
sapiens) 		5 / 12 THR A  40
GLY A  20
GLY A  18
GLY A  66
ASP A 124
 MG  A 701 ( 3.0A)
GNP  A 700 (-3.1A)
GNP  A 700 (-3.6A)
GNP  A 700 (-3.0A)
GNP  A 700 (-3.0A)
 1.06A 2b25A-2ew1A:
2.6		 2b25A-2ew1A:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B25_A_SAMA601_0
(HYPOTHETICAL PROTEIN)		 2fg5 RAS-RELATED PROTEIN
RAB-31
(Homo
sapiens) 		5 / 12 THR A  37
GLY A  17
GLY A  15
GLY A  63
ASP A 121
 MG  A 301 ( 3.2A)
GNP  A 302 (-3.1A)
GNP  A 302 (-3.7A)
GNP  A 302 (-3.2A)
GNP  A 302 (-2.9A)
 1.04A 2b25A-2fg5A:
undetectable		 2b25A-2fg5A:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B25_A_SAMA601_0
(HYPOTHETICAL PROTEIN)		 2g6b RAS-RELATED PROTEIN
RAB-26
(Homo
sapiens) 		5 / 12 THR A  96
GLY A  75
GLY A  73
GLY A 122
ASP A 180
 MG  A 301 ( 3.1A)
GNP  A 302 (-3.3A)
GNP  A 302 (-3.6A)
GNP  A 302 (-3.3A)
GNP  A 302 (-3.0A)
 1.01A 2b25A-2g6bA:
2.6		 2b25A-2g6bA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B25_A_SAMA601_0
(HYPOTHETICAL PROTEIN)		 2ocb RAS-RELATED PROTEIN
RAB-9B
(Homo
sapiens) 		5 / 12 THR A  39
GLY A  19
GLY A  17
GLY A  65
ASP A 127
 MG  A 202 ( 3.2A)
GNP  A 201 (-3.5A)
GNP  A 201 (-3.8A)
GNP  A 201 (-3.2A)
GNP  A 201 (-3.0A)
 0.95A 2b25A-2ocbA:
2.2		 2b25A-2ocbA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B25_A_SAMA601_0
(HYPOTHETICAL PROTEIN)		 3bc1 RAS-RELATED PROTEIN
RAB-27A
(Mus
musculus) 		5 / 12 THR A  41
GLY A  21
GLY A  19
GLY A  77
ASP A 136
 MG  A 194 ( 3.1A)
GNP  A 195 (-3.3A)
GNP  A 195 (-3.7A)
GNP  A 195 (-3.7A)
GNP  A 195 (-2.9A)
 1.07A 2b25A-3bc1A:
undetectable		 2b25A-3bc1A:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B25_A_SAMA601_0
(HYPOTHETICAL PROTEIN)		 3qbt RAS-RELATED PROTEIN
RAB-8A
(Homo
sapiens) 		5 / 12 THR A  40
GLY A  20
GLY A  18
GLY A  66
ASP A 124
 MG  A 201 (-3.2A)
GNP  A 200 (-3.2A)
GNP  A 200 (-3.6A)
GNP  A 200 (-3.2A)
GNP  A 200 (-2.8A)
 0.99A 2b25A-3qbtA:
2.6		 2b25A-3qbtA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B25_A_SAMA601_0
(HYPOTHETICAL PROTEIN)		 3tjz ADP-RIBOSYLATION
FACTOR 1
(Saccharomyces
cerevisiae) 		5 / 12 THR A  48
GLY A  29
GLY A  27
GLY A  70
ASP A 129
 MG  A 202 ( 3.0A)
GNP  A 201 (-3.0A)
GNP  A 201 (-3.4A)
GNP  A 201 (-3.6A)
GNP  A 201 (-2.9A)
 0.98A 2b25A-3tjzA:
undetectable		 2b25A-3tjzA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B25_A_SAMA601_0
(HYPOTHETICAL PROTEIN)		 5szj RAS-RELATED PROTEIN
RAB-10
(Homo
sapiens) 		5 / 12 THR A  41
GLY A  21
GLY A  19
GLY A  67
ASP A 125
 MG  A 302 ( 3.1A)
GNP  A 301 (-3.0A)
GNP  A 301 (-3.5A)
GNP  A 301 (-3.2A)
GNP  A 301 (-3.2A)
 0.99A 2b25A-5szjA:
2.5		 2b25A-5szjA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B25_A_SAMA601_0
(HYPOTHETICAL PROTEIN)		 5wdr RAS PROTEIN
(Choanoflagellida) 		5 / 12 THR A  35
GLY A  15
GLY A  13
GLY A  60
ASP A 119
 MG  A 201 ( 3.1A)
GNP  A 203 (-2.9A)
GNP  A 203 (-3.0A)
GNP  A 203 (-3.2A)
GNP  A 203 (-2.0A)
 0.94A 2b25A-5wdrA:
undetectable		 2b25A-5wdrA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B25_A_SAMA601_0
(HYPOTHETICAL PROTEIN)		 6f76 -
(-) 		5 / 12 THR B  35
GLY B  15
GLY B  13
GLY B  60
ASP B 119
 MG  B 201 ( 3.0A)
GNP  B 202 (-3.2A)
GNP  B 202 (-3.6A)
GNP  B 202 (-3.4A)
GNP  B 202 (-2.9A)
 1.01A 2b25A-6f76B:
undetectable		 2b25A-6f76B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CL5_B_SAMB1217_1
(CATECHOL
O-METHYLTRANSFERASE)		 5wdr RAS PROTEIN
(Choanoflagellida) 		4 / 6 SER A  89
GLU A 144
SER A 146
ASP A  85
 None
None
GNP  A 203 (-3.5A)
None
 1.37A 2cl5B-5wdrA:
undetectable		 2cl5B-5wdrA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EUF_B_LQQB401_1
(CELL DIVISION
PROTEIN KINASE 6)		 4jr7 CASEIN KINASE II
SUBUNIT ALPHA
(Saccharomyces
cerevisiae) 		6 / 12 VAL A  54
LYS A  69
PHE A 152
VAL A 155
ASN A 200
ASP A 214
 GNP  A 401 (-4.2A)
GNP  A 401 (-3.3A)
None
GNP  A 401 (-4.0A)
MG  A 402 ( 2.6A)
GNP  A 401 ( 2.7A)
 0.50A 2eufB-4jr7A:
29.2		 2eufB-4jr7A:
28.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_A_MIXA539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 4jr7 CASEIN KINASE II
SUBUNIT ALPHA
(Saccharomyces
cerevisiae) 		7 / 12 GLY A  47
VAL A  54
VAL A 155
ASP A 195
LYS A 197
ASN A 200
MET A 202
 GNP  A 401 (-3.6A)
GNP  A 401 (-4.2A)
GNP  A 401 (-4.0A)
GNP  A 401 (-4.0A)
GNP  A 401 (-3.4A)
MG  A 402 ( 2.6A)
GNP  A 401 (-3.6A)
 0.84A 2fumA-4jr7A:
23.4		 2fumA-4jr7A:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_A_MIXA539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 4jr7 CASEIN KINASE II
SUBUNIT ALPHA
(Saccharomyces
cerevisiae) 		7 / 12 VAL A  54
VAL A 155
ASP A 195
LYS A 197
ASN A 200
MET A 202
ASP A 214
 GNP  A 401 (-4.2A)
GNP  A 401 (-4.0A)
GNP  A 401 (-4.0A)
GNP  A 401 (-3.4A)
MG  A 402 ( 2.6A)
GNP  A 401 (-3.6A)
GNP  A 401 ( 2.7A)
 0.90A 2fumA-4jr7A:
23.4		 2fumA-4jr7A:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_B_MIXB1539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 4jr7 CASEIN KINASE II
SUBUNIT ALPHA
(Saccharomyces
cerevisiae) 		7 / 12 GLY A  47
VAL A  54
TYR A 154
VAL A 155
LYS A 197
ASN A 200
MET A 202
 GNP  A 401 (-3.6A)
GNP  A 401 (-4.2A)
GNP  A 401 ( 4.5A)
GNP  A 401 (-4.0A)
GNP  A 401 (-3.4A)
MG  A 402 ( 2.6A)
GNP  A 401 (-3.6A)
 0.81A 2fumB-4jr7A:
23.4		 2fumB-4jr7A:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_B_MIXB1539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 4jr7 CASEIN KINASE II
SUBUNIT ALPHA
(Saccharomyces
cerevisiae) 		7 / 12 VAL A  54
TYR A 154
VAL A 155
LYS A 197
ASN A 200
MET A 202
ASP A 214
 GNP  A 401 (-4.2A)
GNP  A 401 ( 4.5A)
GNP  A 401 (-4.0A)
GNP  A 401 (-3.4A)
MG  A 402 ( 2.6A)
GNP  A 401 (-3.6A)
GNP  A 401 ( 2.7A)
 0.92A 2fumB-4jr7A:
23.4		 2fumB-4jr7A:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GJ5_A_VD3A163_1
(BETA-LACTOGLOBULIN)		 3bh6 ADP-RIBOSYLATION
FACTOR-LIKE PROTEIN
3
(Mus
musculus) 		5 / 12 LEU A  22
VAL A 121
ILE A 123
LEU A 122
ALA A 160
 None
None
None
None
GNP  A   1 (-3.7A)
 1.21A 2gj5A-3bh6A:
undetectable		 2gj5A-3bh6A:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GVC_B_MMZB501_1
(MONOOXYGENASE)		 3oes GTPASE RHEBL1
(Homo
sapiens) 		3 / 3 ASN A  41
TYR A  35
SER A  21
 None
GNP  A 201 (-4.5A)
GNP  A 201 (-2.6A)
 0.94A 2gvcB-3oesA:
undetectable		 2gvcB-3oesA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_A_STIA600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4bas ADP-RIBOSYLATION
FACTOR, PUTATIVE
(SMALL GTPASE,
PUTATIVE)
(Trypanosoma
brucei) 		4 / 6 LEU A 161
VAL A  10
VAL A  83
ILE A  24
 GNP  A1182 (-4.3A)
None
None
None
 1.00A 2hyyA-4basA:
undetectable		 2hyyA-4basA:
24.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_B_STIB600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4bas ADP-RIBOSYLATION
FACTOR, PUTATIVE
(SMALL GTPASE,
PUTATIVE)
(Trypanosoma
brucei) 		4 / 6 LEU A 161
VAL A  10
VAL A  83
ILE A  24
 GNP  A1182 (-4.3A)
None
None
None
 0.90A 2hyyB-4basA:
undetectable		 2hyyB-4basA:
24.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OTV_A_NCAA1301_0
(CATIONIC TRYPSIN)		 2q3f RAS-RELATED
GTP-BINDING PROTEIN
D
(Homo
sapiens) 		4 / 6 SER A  54
SER A  57
GLY A 101
GLY A  50
 GNP  A 401 (-3.5A)
MG  A 301 ( 2.1A)
GNP  A 401 (-3.2A)
None
 0.76A 2otvA-2q3fA:
undetectable		 2otvA-2q3fA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OTV_A_NCAA1301_0
(CATIONIC TRYPSIN)		 3r7w GTP-BINDING PROTEIN
GTR1
(Saccharomyces
cerevisiae) 		4 / 6 SER A  17
SER A  20
GLY A  64
GLY A  13
 GNP  A 500 (-3.6A)
MG  A 600 ( 2.0A)
GNP  A 500 (-3.8A)
None
 0.79A 2otvA-3r7wA:
undetectable		 2otvA-3r7wA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OTV_A_NCAA1301_0
(CATIONIC TRYPSIN)		 3zjc GTPASE IMAP FAMILY
MEMBER 7
(Homo
sapiens) 		4 / 6 SER A  19
SER A  22
GLY A  66
GLY A  15
 GNP  A1297 (-3.9A)
MG  A1296 ( 2.4A)
GNP  A1297 ( 4.3A)
None
 0.71A 2otvA-3zjcA:
undetectable		 2otvA-3zjcA:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_B_SAMB300_0
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 5l3q SIGNAL RECOGNITION
PARTICLE RECEPTOR
SUBUNIT ALPHA
(Homo
sapiens) 		5 / 12 GLY B 523
GLY B 551
GLY B 430
GLY B 428
THR B 588
 GNP  B 705 (-3.7A)
None
GNP  B 705 (-3.1A)
GNP  B 705 (-3.4A)
GNP  B 705 ( 4.6A)
 0.81A 2oxtB-5l3qB:
undetectable		 2oxtB-5l3qB:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q83_B_ADNB2_1
(YTAA PROTEIN)		 6cey BIFUNCTIONAL AAC/APH
(Staphylococcus
aureus) 		4 / 6 ILE A 208
PRO A 258
LEU A 381
ILE A 392
 GNP  A 500 ( 4.6A)
None
None
GNP  A 500 (-3.9A)
 0.88A 2q83B-6ceyA:
15.6		 2q83B-6ceyA:
15.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEU_B_ACTB141_0
(PUTATIVE
CARBOXYMUCONOLACTONE
DECARBOXYLASE)		 4zu9 ELONGATION FACTOR
SELB
(Aquifex
aeolicus) 		3 / 3 PRO A  63
ASN A  71
ARG A 256
 GNP  A2001 ( 4.9A)
None
None
 1.06A 2qeuB-4zu9A:
undetectable		 2qeuB-4zu9A:
13.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_A_KLNA1501_1
(CYTOCHROME P450 3A4)		 5l3q SIGNAL RECOGNITION
PARTICLE RECEPTOR
SUBUNIT ALPHA
(Homo
sapiens) 		5 / 10 ASP B 591
ILE B 585
THR B 592
ILE B 582
GLY B 430
 GNP  B 705 (-2.9A)
None
GNP  B 705 ( 4.7A)
None
GNP  B 705 (-3.1A)
 1.19A 2v0mA-5l3qB:
undetectable		 2v0mA-5l3qB:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_C_KLNC1499_1
(CYTOCHROME P450 3A4)		 5szj MICAL
C-TERMINAL-LIKE
PROTEIN
RAS-RELATED PROTEIN
RAB-10
(Homo
sapiens) 		4 / 7 PHE A  38
PHE A  71
PHE B 650
ILE B 657
 GNP  A 301 (-4.0A)
None
None
None
 1.02A 2v0mC-5szjA:
undetectable		 2v0mC-5szjA:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VIN_A_505A1247_1
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR CHAIN B)		 2q3f RAS-RELATED
GTP-BINDING PROTEIN
D
(Homo
sapiens) 		4 / 8 SER A  54
SER A  57
GLY A 101
GLY A  50
 GNP  A 401 (-3.5A)
MG  A 301 ( 2.1A)
GNP  A 401 (-3.2A)
None
 0.75A 2vinA-2q3fA:
undetectable		 2vinA-2q3fA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VIN_A_505A1247_1
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR CHAIN B)		 3r7w GTP-BINDING PROTEIN
GTR1
(Saccharomyces
cerevisiae) 		4 / 8 SER A  17
SER A  20
GLY A  64
GLY A  13
 GNP  A 500 (-3.6A)
MG  A 600 ( 2.0A)
GNP  A 500 (-3.8A)
None
 0.76A 2vinA-3r7wA:
undetectable		 2vinA-3r7wA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VIN_A_505A1247_1
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR CHAIN B)		 3zjc GTPASE IMAP FAMILY
MEMBER 7
(Homo
sapiens) 		4 / 8 SER A  19
SER A  22
GLY A  66
GLY A  15
 GNP  A1297 (-3.9A)
MG  A1296 ( 2.4A)
GNP  A1297 ( 4.3A)
None
 0.69A 2vinA-3zjcA:
undetectable		 2vinA-3zjcA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YY8_B_SAMB500_0
(UPF0106 PROTEIN
PH0461)		 3r9w GTPASE ERA
(Aquifex
aeolicus) 		5 / 11 VAL A   9
GLY A  10
VAL A  14
ILE A  78
ALA A  79
 None
None
GNP  A 402 (-4.1A)
None
None
 1.00A 2yy8A-3r9wA:
undetectable
2yy8B-3r9wA:
undetectable		 2yy8A-3r9wA:
22.30
2yy8B-3r9wA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZS9_A_PAUA603_0
(PANTOTHENATE KINASE)		 4lbw ELONGATION FACTOR
TU-A
(Thermus
thermophilus) 		4 / 6 VAL A 105
ASP A  81
HIS A  79
ASN A 136
 None
MG  A 502 ( 4.0A)
None
GNP  A 501 (-3.2A)
 1.16A 2zs9A-4lbwA:
2.5		 2zs9A-4lbwA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZVJ_A_SAMA301_1
(CATECHOL
O-METHYLTRANSFERASE)		 5wdr RAS PROTEIN
(Choanoflagellida) 		4 / 6 SER A  89
GLU A 144
SER A 146
ASP A  85
 None
None
GNP  A 203 (-3.5A)
None
 1.39A 2zvjA-5wdrA:
undetectable		 2zvjA-5wdrA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A50_C_VD3C2001_1
(VITAMIN D
HYDROXYLASE)		 2ke5 RAS-RELATED PROTEIN
RAL-B
(Homo
sapiens) 		5 / 11 THR A  31
ASN A 128
LEU A  67
ILE A  18
LEU A  72
 None
GNP  A 500 (-4.7A)
None
None
None
 1.26A 3a50C-2ke5A:
undetectable		 3a50C-2ke5A:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A50_E_VD3E2001_1
(VITAMIN D
HYDROXYLASE)		 2ke5 RAS-RELATED PROTEIN
RAL-B
(Homo
sapiens) 		5 / 12 THR A  31
ASN A 128
LEU A  67
ILE A  18
LEU A  72
 None
GNP  A 500 (-4.7A)
None
None
None
 1.24A 3a50E-2ke5A:
undetectable		 3a50E-2ke5A:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G4L_B_ROFB902_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 4jr7 CASEIN KINASE II
SUBUNIT ALPHA
(Saccharomyces
cerevisiae) 		5 / 12 HIS A 193
LEU A  86
ILE A 213
MET A 202
PHE A 152
 None
None
GNP  A 401 (-4.6A)
GNP  A 401 (-3.6A)
None
 1.43A 3g4lB-4jr7A:
undetectable		 3g4lB-4jr7A:
24.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWW_A_SFXA801_1
(TRANSPORTER)		 3r9w GTPASE ERA
(Aquifex
aeolicus) 		5 / 12 LEU A  19
GLY A  15
ILE A 154
ALA A  95
ASP A 126
 None
GNP  A 402 (-3.2A)
None
None
GNP  A 402 (-3.0A)
 1.09A 3gwwA-3r9wA:
undetectable		 3gwwA-3r9wA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HAV_C_SRYC403_1
(AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		 6cey BIFUNCTIONAL AAC/APH
(Staphylococcus
aureus) 		5 / 12 ASN A 373
ASP A 374
SER A 376
ASN A 378
SER A 413
 None
GNP  A 500 (-4.6A)
None
None
None
 1.11A 3havC-6ceyA:
17.1		 3havC-6ceyA:
15.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HLW_B_CE3B304_1
(CTX-M-9
EXTENDED-SPECTRUM
BETA-LACTAMASE)		 3r7w GTP-BINDING PROTEIN
GTR1
(Saccharomyces
cerevisiae) 		4 / 5 ASN A 248
THR A  35
SER A  31
ARG A  36
 None
GNP  A 500 (-4.2A)
None
None
 1.46A 3hlwB-3r7wA:
undetectable		 3hlwB-3r7wA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I9J_B_NCAB302_0
(ADP-RIBOSYL CYCLASE)		 1f5n INTERFERON-INDUCED
GUANYLATE-BINDING
PROTEIN 1
(Homo
sapiens) 		4 / 6 LEU A  67
GLU A 251
SER A  52
PHE A  65
 GNP  A 593 (-3.9A)
None
MG  A 595 ( 2.2A)
None
 1.31A 3i9jB-1f5nA:
undetectable		 3i9jB-1f5nA:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_A_THHA642_1
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		 6cey BIFUNCTIONAL AAC/APH
(Staphylococcus
aureus) 		3 / 3 ASN A 378
ASP A 374
ARG A 475
 None
GNP  A 500 (-4.6A)
None
 0.92A 3k13A-6ceyA:
undetectable		 3k13A-6ceyA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K5V_A_STIA2_2
(TYROSINE-PROTEIN
KINASE ABL1)		 4bas ADP-RIBOSYLATION
FACTOR, PUTATIVE
(SMALL GTPASE,
PUTATIVE)
(Trypanosoma
brucei) 		4 / 6 LEU A 161
VAL A  10
VAL A  83
ILE A  24
 GNP  A1182 (-4.3A)
None
None
None
 0.92A 3k5vA-4basA:
undetectable		 3k5vA-4basA:
24.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K5V_B_STIB2_2
(TYROSINE-PROTEIN
KINASE ABL1)		 4bas ADP-RIBOSYLATION
FACTOR, PUTATIVE
(SMALL GTPASE,
PUTATIVE)
(Trypanosoma
brucei) 		4 / 6 LEU A 161
VAL A  10
VAL A  83
ILE A  24
 GNP  A1182 (-4.3A)
None
None
None
 0.96A 3k5vB-4basA:
undetectable		 3k5vB-4basA:
24.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KMO_A_EAAA214_1
(GLUTATHIONE
S-TRANSFERASE P)		 1ek0 PROTEIN (GTP-BINDING
PROTEIN YPT51)
(Saccharomyces
cerevisiae) 		5 / 9 VAL A  86
GLY A 119
GLN A  66
ASN A 120
GLY A  19
 None
None
GNP  A 501 ( 4.9A)
GNP  A 501 (-3.2A)
GNP  A 501 (-3.3A)
 1.43A 3kmoA-1ek0A:
undetectable		 3kmoA-1ek0A:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KMO_A_EAAA214_1
(GLUTATHIONE
S-TRANSFERASE P)		 1huq RAB5C
(Mus
musculus) 		5 / 9 VAL A 100
GLY A 133
GLN A  80
ASN A 134
GLY A  33
 None
None
None
GNP  A 200 (-3.3A)
GNP  A 200 (-3.4A)
 1.42A 3kmoA-1huqA:
0.0		 3kmoA-1huqA:
24.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KMO_A_EAAA214_1
(GLUTATHIONE
S-TRANSFERASE P)		 1x3s RAS-RELATED PROTEIN
RAB-18
(Homo
sapiens) 		5 / 9 VAL A  87
GLY A 121
GLN A  67
ASN A 122
GLY A  20
 None
None
None
GNP  A 300 (-3.2A)
GNP  A 300 (-3.3A)
 1.36A 3kmoA-1x3sA:
undetectable		 3kmoA-1x3sA:
23.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KMO_A_EAAA214_1
(GLUTATHIONE
S-TRANSFERASE P)		 1yzn GTP-BINDING PROTEIN
YPT1
(Saccharomyces
cerevisiae) 		5 / 9 VAL A  87
GLY A 120
GLN A  67
ASN A 121
GLY A  20
 None
None
None
GNP  A 300 (-3.2A)
GNP  A 300 (-3.3A)
 1.39A 3kmoA-1yznA:
undetectable		 3kmoA-1yznA:
24.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KMO_A_EAAA214_1
(GLUTATHIONE
S-TRANSFERASE P)		 1z06 RAS-RELATED PROTEIN
RAB-33B
(Mus
musculus) 		5 / 9 VAL A 113
GLY A 147
GLN A  92
ASN A 148
GLY A  45
 None
None
None
GNP  A 204 (-3.3A)
GNP  A 204 (-3.1A)
 1.44A 3kmoA-1z06A:
undetectable		 3kmoA-1z06A:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KMO_A_EAAA214_1
(GLUTATHIONE
S-TRANSFERASE P)		 5szj RAS-RELATED PROTEIN
RAB-10
(Homo
sapiens) 		5 / 9 VAL A  88
GLY A 121
GLN A  68
ASN A 122
GLY A  21
 None
None
None
GNP  A 301 (-3.2A)
GNP  A 301 (-3.0A)
 1.44A 3kmoA-5szjA:
undetectable		 3kmoA-5szjA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KMO_A_EAAA214_1
(GLUTATHIONE
S-TRANSFERASE P)		 5wdr RAS PROTEIN
(Choanoflagellida) 		5 / 9 VAL A  81
GLY A 115
GLN A  61
ASN A 116
GLY A  15
 None
None
GNP  A 203 ( 4.5A)
GNP  A 203 (-3.2A)
GNP  A 203 (-2.9A)
 1.41A 3kmoA-5wdrA:
undetectable		 3kmoA-5wdrA:
24.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LFA_A_1N1A361_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 4jr7 CASEIN KINASE II
SUBUNIT ALPHA
(Saccharomyces
cerevisiae) 		4 / 8 VAL A  46
LYS A  69
GLU A  82
LEU A 150
 GNP  A 401 (-4.2A)
GNP  A 401 (-3.3A)
None
None
 0.33A 3lfaA-4jr7A:
23.3		 3lfaA-4jr7A:
26.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LP1_A_NVPA701_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 3bc1 RAS-RELATED PROTEIN
RAB-27A
(Mus
musculus) 		5 / 10 ASN A 133
VAL A  20
VAL A  25
GLY A  21
LEU A  97
 GNP  A 195 (-3.2A)
GNP  A 195 ( 4.1A)
None
GNP  A 195 (-3.3A)
None
 1.43A 3lp1A-3bc1A:
undetectable		 3lp1A-3bc1A:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NVK_I_SAMI228_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 5gad SIGNAL RECOGNITION
PARTICLE RECEPTOR
FTSY
(Escherichia
coli) 		5 / 12 GLY l 329
THR l 307
ILE l 364
ALA l 361
ASP l 330
 None
MG  l1401 ( 3.1A)
None
G  1  54 ( 3.3A)
GNP  l1400 ( 4.7A)
 1.14A 3nvkI-5gadl:
undetectable		 3nvkI-5gadl:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_A_1N1A1000_1
(P38A)		 4jr7 CASEIN KINASE II
SUBUNIT ALPHA
(Saccharomyces
cerevisiae) 		6 / 12 VAL A  46
GLY A  47
VAL A  54
LYS A  69
LEU A  86
ILE A 134
 GNP  A 401 (-4.2A)
GNP  A 401 (-3.6A)
GNP  A 401 (-4.2A)
GNP  A 401 (-3.3A)
None
None
 0.75A 3ohtA-4jr7A:
5.2		 3ohtA-4jr7A:
27.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_A_SAMA300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 2px0 FLAGELLAR
BIOSYNTHESIS PROTEIN
FLHF
(Bacillus
subtilis) 		5 / 12 LEU A 288
GLY A 187
GLY A 182
SER A 183
ALA A 193
 None
GNP  A   1 ( 3.2A)
None
None
None
 1.12A 3ou6A-2px0A:
undetectable		 3ou6A-2px0A:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_B_SAMB300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 2px0 FLAGELLAR
BIOSYNTHESIS PROTEIN
FLHF
(Bacillus
subtilis) 		5 / 12 LEU A 288
GLY A 187
GLY A 182
SER A 183
ALA A 193
 None
GNP  A   1 ( 3.2A)
None
None
None
 1.10A 3ou7B-2px0A:
undetectable		 3ou7B-2px0A:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PWW_A_ROCA1001_1
(ENDOTHIAPEPSIN)		 2fg5 RAS-RELATED PROTEIN
RAB-31
(Homo
sapiens) 		5 / 12 ILE A 153
ASP A 121
GLY A  15
LEU A 122
ILE A  34
 None
GNP  A 302 (-2.9A)
GNP  A 302 (-3.7A)
GNP  A 302 (-4.2A)
GNP  A 302 (-4.2A)
 1.12A 3pwwA-2fg5A:
undetectable		 3pwwA-2fg5A:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RXF_A_4APA9_1
(CATIONIC TRYPSIN)		 2q3f RAS-RELATED
GTP-BINDING PROTEIN
D
(Homo
sapiens) 		4 / 6 SER A  54
SER A  57
GLY A 101
GLY A  50
 GNP  A 401 (-3.5A)
MG  A 301 ( 2.1A)
GNP  A 401 (-3.2A)
None
 0.68A 3rxfA-2q3fA:
undetectable		 3rxfA-2q3fA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RXF_A_4APA9_1
(CATIONIC TRYPSIN)		 3zjc GTPASE IMAP FAMILY
MEMBER 7
(Homo
sapiens) 		4 / 6 SER A  19
SER A  22
GLY A  66
GLY A  15
 GNP  A1297 (-3.9A)
MG  A1296 ( 2.4A)
GNP  A1297 ( 4.3A)
None
 0.68A 3rxfA-3zjcA:
undetectable		 3rxfA-3zjcA:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SG8_A_TOYA305_1
(APH(2'')-ID)		 6cey BIFUNCTIONAL AAC/APH
(Staphylococcus
aureus) 		6 / 12 ASP A 374
SER A 376
HIS A 379
ASP A 396
GLU A 411
GLU A 416
 GNP  A 500 (-4.6A)
None
MG  A 700 ( 3.2A)
MG  A 702 ( 4.8A)
None
None
 0.43A 3sg8A-6ceyA:
30.7		 3sg8A-6ceyA:
14.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SG8_A_TOYA305_1
(APH(2'')-ID)		 6cey BIFUNCTIONAL AAC/APH
(Staphylococcus
aureus) 		6 / 12 ASP A 374
SER A 376
HIS A 379
GLU A 411
GLU A 415
GLU A 416
 GNP  A 500 (-4.6A)
None
MG  A 700 ( 3.2A)
None
None
None
 0.70A 3sg8A-6ceyA:
30.7		 3sg8A-6ceyA:
14.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SG8_B_TOYB305_1
(APH(2'')-ID)		 6cey BIFUNCTIONAL AAC/APH
(Staphylococcus
aureus) 		6 / 12 ASP A 374
SER A 376
HIS A 379
ASP A 396
GLU A 411
GLU A 416
 GNP  A 500 (-4.6A)
None
MG  A 700 ( 3.2A)
MG  A 702 ( 4.8A)
None
None
 0.57A 3sg8B-6ceyA:
31.0		 3sg8B-6ceyA:
14.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SG8_B_TOYB305_1
(APH(2'')-ID)		 6cey BIFUNCTIONAL AAC/APH
(Staphylococcus
aureus) 		6 / 12 ASP A 374
SER A 376
HIS A 379
ASP A 396
GLU A 411
GLU A 416
 GNP  A 500 (-4.6A)
None
MG  A 700 ( 3.2A)
MG  A 702 ( 4.8A)
None
None
 1.44A 3sg8B-6ceyA:
31.0		 3sg8B-6ceyA:
14.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SG9_A_KANA304_1
(APH(2'')-ID)		 6cey BIFUNCTIONAL AAC/APH
(Staphylococcus
aureus) 		6 / 10 ASP A 374
SER A 376
HIS A 379
ASP A 396
GLU A 411
GLU A 416
 GNP  A 500 (-4.6A)
None
MG  A 700 ( 3.2A)
MG  A 702 ( 4.8A)
None
None
 0.43A 3sg9A-6ceyA:
30.7		 3sg9A-6ceyA:
14.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SG9_A_KANA304_1
(APH(2'')-ID)		 6cey BIFUNCTIONAL AAC/APH
(Staphylococcus
aureus) 		6 / 10 ASP A 374
SER A 376
HIS A 379
ASP A 396
GLU A 411
GLU A 416
 GNP  A 500 (-4.6A)
None
MG  A 700 ( 3.2A)
MG  A 702 ( 4.8A)
None
None
 1.46A 3sg9A-6ceyA:
30.7		 3sg9A-6ceyA:
14.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SG9_A_KANA304_1
(APH(2'')-ID)		 6cey BIFUNCTIONAL AAC/APH
(Staphylococcus
aureus) 		6 / 10 ASP A 374
SER A 376
HIS A 379
ASP A 396
GLU A 415
GLU A 416
 GNP  A 500 (-4.6A)
None
MG  A 700 ( 3.2A)
MG  A 702 ( 4.8A)
None
None
 0.91A 3sg9A-6ceyA:
30.7		 3sg9A-6ceyA:
14.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SG9_B_KANB305_1
(APH(2'')-ID)		 6cey BIFUNCTIONAL AAC/APH
(Staphylococcus
aureus) 		6 / 8 ASP A 374
SER A 376
HIS A 379
ASP A 396
GLU A 411
GLU A 445
 GNP  A 500 (-4.6A)
None
MG  A 700 ( 3.2A)
MG  A 702 ( 4.8A)
None
None
 0.83A 3sg9B-6ceyA:
30.8		 3sg9B-6ceyA:
14.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_B_ACTB4_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 2ew1 RAS-RELATED PROTEIN
RAB-30
(Homo
sapiens) 		3 / 3 GLY A  18
GLY A  20
THR A  22
 GNP  A 700 (-3.6A)
GNP  A 700 (-3.1A)
MG  A 701 ( 3.0A)
 0.45A 3si7B-2ew1A:
undetectable		 3si7B-2ew1A:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_B_ACTB4_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 2g6b RAS-RELATED PROTEIN
RAB-26
(Homo
sapiens) 		3 / 3 GLY A  73
GLY A  75
THR A  77
 GNP  A 302 (-3.6A)
GNP  A 302 (-3.3A)
MG  A 301 ( 3.0A)
 0.45A 3si7B-2g6bA:
undetectable		 3si7B-2g6bA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_B_ACTB4_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 3bc1 RAS-RELATED PROTEIN
RAB-27A
(Mus
musculus) 		3 / 3 GLY A  19
GLY A  21
THR A  23
 GNP  A 195 (-3.7A)
GNP  A 195 (-3.3A)
MG  A 194 ( 3.1A)
 0.42A 3si7B-3bc1A:
undetectable		 3si7B-3bc1A:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T7S_C_SAMC300_0
(PUTATIVE
METHYLTRANSFERASE)		 3q7p GTP-BINDING PROTEIN
RAD
(Homo
sapiens) 		5 / 12 GLY A 103
GLY A 101
SER A 233
GLU A 147
ALA A 106
 GNP  A 256 (-3.2A)
GNP  A 256 (-3.5A)
GNP  A 256 (-3.6A)
MG  A 257 ( 2.8A)
GNP  A 256 (-3.1A)
 1.44A 3t7sC-3q7pA:
undetectable		 3t7sC-3q7pA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V1N_A_BEZA288_0
(2-HYDROXY-6-OXO-6-PH
ENYLHEXA-2,4-DIENOAT
E HYDROLASE)		 1r4a ADP-RIBOSYLATION
FACTOR-LIKE PROTEIN
1
(Rattus
norvegicus) 		5 / 8 GLY A  70
GLY A  69
GLY A  29
ILE A  22
VAL A  91
 GNP  A1201 (-3.9A)
GNP  A1201 (-3.6A)
GNP  A1201 (-3.1A)
None
None
 0.94A 3v1nA-1r4aA:
4.4		 3v1nA-1r4aA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VQR_A_ACTA1002_0
(PUTATIVE
OXIDOREDUCTASE)		 3bc1 RAS-RELATED PROTEIN
RAB-27A
(Mus
musculus) 		4 / 6 ASP A  17
GLY A  19
VAL A  20
ASP A 100
 None
GNP  A 195 (-3.7A)
GNP  A 195 ( 4.1A)
None
 1.15A 3vqrA-3bc1A:
undetectable		 3vqrA-3bc1A:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VQR_A_ACTA1002_0
(PUTATIVE
OXIDOREDUCTASE)		 5xr6 RAS-RELATED PROTEIN
RABA1A
(Arabidopsis
thaliana) 		4 / 6 ASP A  21
GLY A  23
VAL A  24
ASP A  94
 None
GNP  A 301 (-3.4A)
GNP  A 301 (-4.1A)
None
 1.16A 3vqrA-5xr6A:
undetectable		 3vqrA-5xr6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VQR_B_ACTB1002_0
(PUTATIVE
OXIDOREDUCTASE)		 3bc1 RAS-RELATED PROTEIN
RAB-27A
(Mus
musculus) 		4 / 5 ASP A  17
GLY A  19
VAL A  20
ASP A 100
 None
GNP  A 195 (-3.7A)
GNP  A 195 ( 4.1A)
None
 1.16A 3vqrB-3bc1A:
undetectable		 3vqrB-3bc1A:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VQR_B_ACTB1002_0
(PUTATIVE
OXIDOREDUCTASE)		 5xr6 RAS-RELATED PROTEIN
RABA1A
(Arabidopsis
thaliana) 		4 / 5 ASP A  21
GLY A  23
VAL A  24
ASP A  94
 None
GNP  A 301 (-3.4A)
GNP  A 301 (-4.1A)
None
 1.17A 3vqrB-5xr6A:
undetectable		 3vqrB-5xr6A:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3WAR_A_NIOA401_1
(CASEIN KINASE II
SUBUNIT ALPHA)		 4jr7 CASEIN KINASE II
SUBUNIT ALPHA
(Saccharomyces
cerevisiae) 		8 / 8 VAL A  54
VAL A  67
LYS A  69
ILE A 134
PHE A 152
MET A 202
ILE A 213
ASP A 214
 GNP  A 401 (-4.2A)
GNP  A 401 (-4.8A)
GNP  A 401 (-3.3A)
None
None
GNP  A 401 (-3.6A)
GNP  A 401 (-4.6A)
GNP  A 401 ( 2.7A)
 0.30A 3warA-4jr7A:
46.1		 3warA-4jr7A:
56.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRK_D_CAMD502_0
(CAMPHOR
5-MONOOXYGENASE)		 2g6b RAS-RELATED PROTEIN
RAB-26
(Homo
sapiens) 		4 / 5 PHE A 218
LEU A 143
GLY A  75
VAL A  81
 None
None
GNP  A 302 (-3.3A)
None
 1.02A 3wrkD-2g6bA:
undetectable		 3wrkD-2g6bA:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1477_0
(MJ0495-LIKE PROTEIN)		 5l3s SIGNAL RECOGNITION
PARTICLE 54 KDA
PROTEIN
(Sulfolobus
solfataricus) 		4 / 6 THR A 111
GLY A 114
ILE A 150
LEU A 279
 GNP  A 301 (-3.7A)
None
None
None
 0.94A 4ac9C-5l3sA:
7.4		 4ac9C-5l3sA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACB_C_DXCC1477_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 5l3s SIGNAL RECOGNITION
PARTICLE 54 KDA
PROTEIN
(Sulfolobus
solfataricus) 		4 / 6 THR A 111
GLY A 114
ILE A 150
LEU A 279
 GNP  A 301 (-3.7A)
None
None
None
 1.02A 4acbC-5l3sA:
7.1		 4acbC-5l3sA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BKJ_B_STIB1000_2
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 4jr7 CASEIN KINASE II
SUBUNIT ALPHA
(Saccharomyces
cerevisiae) 		4 / 5 LYS A  69
LEU A  89
TYR A 154
ARG A 194
 GNP  A 401 (-3.3A)
None
GNP  A 401 ( 4.5A)
None
 1.33A 4bkjB-4jr7A:
18.9		 4bkjB-4jr7A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DF2_A_4CHA506_0
(NADPH DEHYDROGENASE)		 6cey BIFUNCTIONAL AAC/APH
(Staphylococcus
aureus) 		4 / 6 TYR A 244
HIS A 372
HIS A 379
TYR A 237
 None
None
MG  A 700 ( 3.2A)
GNP  A 500 (-4.7A)
 0.86A 4df2A-6ceyA:
undetectable		 4df2A-6ceyA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DFB_A_KANA401_1
(APH(2')-ID)		 6cey BIFUNCTIONAL AAC/APH
(Staphylococcus
aureus) 		5 / 9 ASP A 374
SER A 376
HIS A 379
ASP A 396
GLU A 416
 GNP  A 500 (-4.6A)
None
MG  A 700 ( 3.2A)
MG  A 702 ( 4.8A)
None
 0.44A 4dfbA-6ceyA:
30.6		 4dfbA-6ceyA:
13.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DFB_B_KANB401_1
(APH(2')-ID)		 6cey BIFUNCTIONAL AAC/APH
(Staphylococcus
aureus) 		7 / 10 ASP A 374
SER A 376
HIS A 379
ASP A 396
GLU A 411
GLU A 416
GLU A 445
 GNP  A 500 (-4.6A)
None
MG  A 700 ( 3.2A)
MG  A 702 ( 4.8A)
None
None
None
 0.75A 4dfbB-6ceyA:
31.0		 4dfbB-6ceyA:
13.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DFU_A_KANA401_1
(APH(2')-ID)		 6cey BIFUNCTIONAL AAC/APH
(Staphylococcus
aureus) 		6 / 12 ASP A 374
SER A 376
HIS A 379
ASP A 396
GLU A 411
GLU A 416
 GNP  A 500 (-4.6A)
None
MG  A 700 ( 3.2A)
MG  A 702 ( 4.8A)
None
None
 0.53A 4dfuA-6ceyA:
31.3		 4dfuA-6ceyA:
13.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DFU_B_KANB402_1
(APH(2')-ID)		 6cey BIFUNCTIONAL AAC/APH
(Staphylococcus
aureus) 		6 / 12 ASP A 374
SER A 376
HIS A 379
ASP A 396
GLU A 411
GLU A 416
 GNP  A 500 (-4.6A)
None
MG  A 700 ( 3.2A)
MG  A 702 ( 4.8A)
None
None
 0.52A 4dfuB-6ceyA:
31.2		 4dfuB-6ceyA:
13.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DJE_A_C2FA300_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 3c5h GLUCOCORTICOID
RECEPTOR DNA-BINDING
FACTOR 1
(Homo
sapiens) 		5 / 12 GLU A  95
PHE A  99
ASP A 165
GLY A  34
SER A  36
 MG  A 302 ( 2.6A)
None
None
GNP  A 301 (-3.2A)
MG  A 302 ( 2.1A)
 1.23A 4djeA-3c5hA:
undetectable		 4djeA-3c5hA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DJE_B_C2FB302_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 3c5h GLUCOCORTICOID
RECEPTOR DNA-BINDING
FACTOR 1
(Homo
sapiens) 		5 / 12 GLU A  95
PHE A  99
ASP A 165
GLY A  34
SER A  36
 MG  A 302 ( 2.6A)
None
None
GNP  A 301 (-3.2A)
MG  A 302 ( 2.1A)
 1.06A 4djeB-3c5hA:
undetectable		 4djeB-3c5hA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DJF_A_C2FA300_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 3c5h GLUCOCORTICOID
RECEPTOR DNA-BINDING
FACTOR 1
(Homo
sapiens) 		5 / 12 GLU A  95
PHE A  99
ASP A 165
GLY A  34
SER A  36
 MG  A 302 ( 2.6A)
None
None
GNP  A 301 (-3.2A)
MG  A 302 ( 2.1A)
 1.14A 4djfA-3c5hA:
2.1		 4djfA-3c5hA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DM8_B_REAB1501_1
(RETINOIC ACID
RECEPTOR BETA)		 2g6b RAS-RELATED PROTEIN
RAB-26
(Homo
sapiens) 		5 / 12 ALA A 217
LEU A 143
LEU A 175
ARG A 189
GLY A  75
 None
None
None
None
GNP  A 302 (-3.3A)
 1.02A 4dm8B-2g6bA:
undetectable		 4dm8B-2g6bA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DM8_B_REAB1501_1
(RETINOIC ACID
RECEPTOR BETA)		 2g6b RAS-RELATED PROTEIN
RAB-26
(Homo
sapiens) 		5 / 12 LEU A 216
ALA A 217
LEU A 143
LEU A 175
GLY A  75
 None
None
None
None
GNP  A 302 (-3.3A)
 0.69A 4dm8B-2g6bA:
undetectable		 4dm8B-2g6bA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DT8_A_ADNA401_1
(APH(2'')-ID)		 6cey BIFUNCTIONAL AAC/APH
(Staphylococcus
aureus) 		5 / 11 ALA A 216
LYS A 226
PRO A 258
HIS A 379
ASP A 393
 GNP  A 500 ( 3.9A)
GNP  A 500 (-2.7A)
None
MG  A 700 ( 3.2A)
MG  A 702 (-1.7A)
 1.04A 4dt8A-6ceyA:
30.7		 4dt8A-6ceyA:
14.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DT8_A_ADNA401_1
(APH(2'')-ID)		 6cey BIFUNCTIONAL AAC/APH
(Staphylococcus
aureus) 		8 / 11 GLY A 209
ALA A 216
ILE A 224
LYS A 226
PRO A 258
ILE A 277
HIS A 379
ILE A 392
 GNP  A 500 ( 4.3A)
GNP  A 500 ( 3.9A)
GNP  A 500 (-3.7A)
GNP  A 500 (-2.7A)
None
GNP  A 500 (-3.8A)
MG  A 700 ( 3.2A)
GNP  A 500 (-3.9A)
 0.63A 4dt8A-6ceyA:
30.7		 4dt8A-6ceyA:
14.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DT8_A_ADNA401_1
(APH(2'')-ID)		 6cey BIFUNCTIONAL AAC/APH
(Staphylococcus
aureus) 		8 / 11 GLY A 209
ALA A 216
ILE A 224
PRO A 258
ILE A 277
HIS A 379
LEU A 381
ILE A 392
 GNP  A 500 ( 4.3A)
GNP  A 500 ( 3.9A)
GNP  A 500 (-3.7A)
None
GNP  A 500 (-3.8A)
MG  A 700 ( 3.2A)
None
GNP  A 500 (-3.9A)
 0.69A 4dt8A-6ceyA:
30.7		 4dt8A-6ceyA:
14.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DT8_B_ADNB401_1
(APH(2'')-ID)		 6cey BIFUNCTIONAL AAC/APH
(Staphylococcus
aureus) 		6 / 10 GLY A 209
ALA A 216
ILE A 224
LYS A 226
PRO A 258
ASP A 393
 GNP  A 500 ( 4.3A)
GNP  A 500 ( 3.9A)
GNP  A 500 (-3.7A)
GNP  A 500 (-2.7A)
None
MG  A 702 (-1.7A)
 0.89A 4dt8B-6ceyA:
30.6		 4dt8B-6ceyA:
14.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DT8_B_ADNB401_1
(APH(2'')-ID)		 6cey BIFUNCTIONAL AAC/APH
(Staphylococcus
aureus) 		7 / 10 GLY A 209
ALA A 216
ILE A 224
LYS A 226
PRO A 258
ILE A 277
ILE A 392
 GNP  A 500 ( 4.3A)
GNP  A 500 ( 3.9A)
GNP  A 500 (-3.7A)
GNP  A 500 (-2.7A)
None
GNP  A 500 (-3.8A)
GNP  A 500 (-3.9A)
 0.61A 4dt8B-6ceyA:
30.6		 4dt8B-6ceyA:
14.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DT8_B_ADNB401_1
(APH(2'')-ID)		 6cey BIFUNCTIONAL AAC/APH
(Staphylococcus
aureus) 		7 / 10 GLY A 209
ALA A 216
ILE A 224
PRO A 258
ILE A 277
LEU A 381
ILE A 392
 GNP  A 500 ( 4.3A)
GNP  A 500 ( 3.9A)
GNP  A 500 (-3.7A)
None
GNP  A 500 (-3.8A)
None
GNP  A 500 (-3.9A)
 0.66A 4dt8B-6ceyA:
30.6		 4dt8B-6ceyA:
14.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DTA_A_ADNA401_1
(APH(2'')-ID)		 6cey BIFUNCTIONAL AAC/APH
(Staphylococcus
aureus) 		7 / 10 ALA A 216
ILE A 224
LYS A 226
PRO A 258
ILE A 277
HIS A 379
ILE A 392
 GNP  A 500 ( 3.9A)
GNP  A 500 (-3.7A)
GNP  A 500 (-2.7A)
None
GNP  A 500 (-3.8A)
MG  A 700 ( 3.2A)
GNP  A 500 (-3.9A)
 0.57A 4dtaA-6ceyA:
30.7		 4dtaA-6ceyA:
14.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DTA_A_ADNA401_1
(APH(2'')-ID)		 6cey BIFUNCTIONAL AAC/APH
(Staphylococcus
aureus) 		7 / 10 ALA A 216
ILE A 224
PRO A 258
ILE A 277
HIS A 379
LEU A 381
ILE A 392
 GNP  A 500 ( 3.9A)
GNP  A 500 (-3.7A)
None
GNP  A 500 (-3.8A)
MG  A 700 ( 3.2A)
None
GNP  A 500 (-3.9A)
 0.62A 4dtaA-6ceyA:
30.7		 4dtaA-6ceyA:
14.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DTA_A_ADNA401_1
(APH(2'')-ID)		 6cey BIFUNCTIONAL AAC/APH
(Staphylococcus
aureus) 		5 / 10 ALA A 216
LYS A 226
PRO A 258
HIS A 379
ASP A 393
 GNP  A 500 ( 3.9A)
GNP  A 500 (-2.7A)
None
MG  A 700 ( 3.2A)
MG  A 702 (-1.7A)
 1.00A 4dtaA-6ceyA:
30.7		 4dtaA-6ceyA:
14.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DTA_B_ADNB401_1
(APH(2'')-ID)		 6cey BIFUNCTIONAL AAC/APH
(Staphylococcus
aureus) 		5 / 8 ILE A 224
PRO A 258
ILE A 277
LEU A 381
ILE A 392
 GNP  A 500 (-3.7A)
None
GNP  A 500 (-3.8A)
None
GNP  A 500 (-3.9A)
 0.57A 4dtaB-6ceyA:
30.8		 4dtaB-6ceyA:
14.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEU_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 6cey BIFUNCTIONAL AAC/APH
(Staphylococcus
aureus) 		4 / 7 ASP A 396
ASP A 393
ASP A 213
GLU A 240
 MG  A 702 ( 4.8A)
MG  A 702 (-1.7A)
None
GNP  A 500 ( 4.4A)
 1.13A 4feuB-6ceyA:
17.3		 4feuB-6ceyA:
16.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEU_F_KANF301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 6cey BIFUNCTIONAL AAC/APH
(Staphylococcus
aureus) 		4 / 8 ASP A 396
ASP A 393
ASP A 213
GLU A 240
 MG  A 702 ( 4.8A)
MG  A 702 (-1.7A)
None
GNP  A 500 ( 4.4A)
 1.20A 4feuF-6ceyA:
17.8		 4feuF-6ceyA:
16.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEV_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 6cey BIFUNCTIONAL AAC/APH
(Staphylococcus
aureus) 		4 / 7 ASP A 396
ASP A 393
ASP A 213
GLU A 240
 MG  A 702 ( 4.8A)
MG  A 702 (-1.7A)
None
GNP  A 500 ( 4.4A)
 1.17A 4fevB-6ceyA:
17.5		 4fevB-6ceyA:
16.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEV_D_KAND301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 6cey BIFUNCTIONAL AAC/APH
(Staphylococcus
aureus) 		4 / 7 ASP A 396
ASP A 393
ASP A 213
GLU A 240
 MG  A 702 ( 4.8A)
MG  A 702 (-1.7A)
None
GNP  A 500 ( 4.4A)
 1.16A 4fevD-6ceyA:
18.6		 4fevD-6ceyA:
16.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEV_F_KANF301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 6cey BIFUNCTIONAL AAC/APH
(Staphylococcus
aureus) 		4 / 7 ASP A 396
ASP A 393
ASP A 213
GLU A 240
 MG  A 702 ( 4.8A)
MG  A 702 (-1.7A)
None
GNP  A 500 ( 4.4A)
 1.17A 4fevF-6ceyA:
17.8		 4fevF-6ceyA:
16.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEW_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 6cey BIFUNCTIONAL AAC/APH
(Staphylococcus
aureus) 		4 / 7 ASP A 396
ASP A 393
ASP A 213
GLU A 240
 MG  A 702 ( 4.8A)
MG  A 702 (-1.7A)
None
GNP  A 500 ( 4.4A)
 1.19A 4fewB-6ceyA:
17.8		 4fewB-6ceyA:
16.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEW_D_KAND301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 6cey BIFUNCTIONAL AAC/APH
(Staphylococcus
aureus) 		4 / 8 ASP A 396
ASP A 393
ASP A 213
GLU A 240
 MG  A 702 ( 4.8A)
MG  A 702 (-1.7A)
None
GNP  A 500 ( 4.4A)
 1.15A 4fewD-6ceyA:
18.4		 4fewD-6ceyA:
16.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEW_F_KANF301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 6cey BIFUNCTIONAL AAC/APH
(Staphylococcus
aureus) 		4 / 8 ASP A 396
ASP A 393
ASP A 213
GLU A 240
 MG  A 702 ( 4.8A)
MG  A 702 (-1.7A)
None
GNP  A 500 ( 4.4A)
 1.14A 4fewF-6ceyA:
18.1		 4fewF-6ceyA:
16.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEX_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 6cey BIFUNCTIONAL AAC/APH
(Staphylococcus
aureus) 		4 / 7 ASP A 396
ASP A 393
ASP A 213
GLU A 240
 MG  A 702 ( 4.8A)
MG  A 702 (-1.7A)
None
GNP  A 500 ( 4.4A)
 1.17A 4fexB-6ceyA:
17.7		 4fexB-6ceyA:
16.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FO4_A_MOAA502_1
(INOSINE
5'-MONOPHOSPHATE
DEHYDROGENASE)		 4bas ADP-RIBOSYLATION
FACTOR, PUTATIVE
(SMALL GTPASE,
PUTATIVE)
(Trypanosoma
brucei) 		4 / 8 ASP A  85
SER A  18
ASN A  17
GLY A 160
 None
GNP  A1182 (-3.3A)
GNP  A1182 (-3.9A)
GNP  A1182 (-3.7A)
 0.93A 4fo4A-4basA:
undetectable		 4fo4A-4basA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FR0_A_SAMA401_0
(ARSENIC
METHYLTRANSFERASE)		 1puj CONSERVED
HYPOTHETICAL PROTEIN
YLQF
(Bacillus
subtilis) 		5 / 12 GLY A 127
GLY A 174
ASP A 171
LEU A 176
VAL A 131
 None
GNP  A 501 (-3.1A)
MG  A9001 ( 4.2A)
None
GNP  A 501 (-4.2A)
 0.96A 4fr0A-1pujA:
2.0		 4fr0A-1pujA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FR0_A_SAMA401_0
(ARSENIC
METHYLTRANSFERASE)		 2j7p CELL DIVISION
PROTEIN FTSY
(Thermus
aquaticus) 		5 / 12 GLY D 109
GLY D 194
ASP D 191
LEU D 196
VAL D 113
 None
GNP  D1400 (-3.3A)
MG  D1401 ( 4.0A)
None
GNP  D1400 (-4.1A)
 0.97A 4fr0A-2j7pD:
2.3		 4fr0A-2j7pD:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FR0_A_SAMA401_0
(ARSENIC
METHYLTRANSFERASE)		 5gad SIGNAL RECOGNITION
PARTICLE RECEPTOR
FTSY
(Escherichia
coli) 		5 / 12 GLY l 300
GLY l 385
ASP l 382
LEU l 387
VAL l 304
 None
GNP  l1400 ( 3.3A)
MG  l1401 ( 4.1A)
None
GNP  l1400 ( 4.1A)
 0.97A 4fr0A-5gadl:
undetectable		 4fr0A-5gadl:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 6cey BIFUNCTIONAL AAC/APH
(Staphylococcus
aureus) 		4 / 8 ASP A 396
ASP A 393
ASP A 213
GLU A 240
 MG  A 702 ( 4.8A)
MG  A 702 (-1.7A)
None
GNP  A 500 ( 4.4A)
 1.14A 4gkhB-6ceyA:
18.4		 4gkhB-6ceyA:
16.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_D_KAND301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 6cey BIFUNCTIONAL AAC/APH
(Staphylococcus
aureus) 		4 / 8 ASP A 396
ASP A 393
ASP A 213
GLU A 240
 MG  A 702 ( 4.8A)
MG  A 702 (-1.7A)
None
GNP  A 500 ( 4.4A)
 1.16A 4gkhD-6ceyA:
18.2		 4gkhD-6ceyA:
16.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_F_KANF301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 6cey BIFUNCTIONAL AAC/APH
(Staphylococcus
aureus) 		4 / 8 ASP A 396
ASP A 393
ASP A 213
GLU A 240
 MG  A 702 ( 4.8A)
MG  A 702 (-1.7A)
None
GNP  A 500 ( 4.4A)
 1.14A 4gkhF-6ceyA:
18.2		 4gkhF-6ceyA:
16.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_G_KANG301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 6cey BIFUNCTIONAL AAC/APH
(Staphylococcus
aureus) 		4 / 7 ASP A 396
ASP A 393
ASP A 213
GLU A 240
 MG  A 702 ( 4.8A)
MG  A 702 (-1.7A)
None
GNP  A 500 ( 4.4A)
 1.15A 4gkhG-6ceyA:
17.8		 4gkhG-6ceyA:
16.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_J_KANJ301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 6cey BIFUNCTIONAL AAC/APH
(Staphylococcus
aureus) 		4 / 6 ASP A 396
ASP A 393
ASP A 213
GLU A 240
 MG  A 702 ( 4.8A)
MG  A 702 (-1.7A)
None
GNP  A 500 ( 4.4A)
 1.20A 4gkhJ-6ceyA:
18.1		 4gkhJ-6ceyA:
16.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKI_A_KANA301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 6cey BIFUNCTIONAL AAC/APH
(Staphylococcus
aureus) 		4 / 8 ASP A 396
ASP A 393
ASP A 213
GLU A 240
 MG  A 702 ( 4.8A)
MG  A 702 (-1.7A)
None
GNP  A 500 ( 4.4A)
 1.13A 4gkiA-6ceyA:
18.3		 4gkiA-6ceyA:
16.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKI_C_KANC301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 6cey BIFUNCTIONAL AAC/APH
(Staphylococcus
aureus) 		4 / 8 ASP A 396
ASP A 393
ASP A 213
GLU A 240
 MG  A 702 ( 4.8A)
MG  A 702 (-1.7A)
None
GNP  A 500 ( 4.4A)
 1.15A 4gkiC-6ceyA:
18.0		 4gkiC-6ceyA:
16.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYT_A_OBNA1104_2
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 2qtv SMALL COPII COAT
GTPASE SAR1
(Saccharomyces
cerevisiae) 		4 / 5 ASP B  99
ASN B 132
ILE B 134
VAL B 174
 None
GNP  B 200 (-3.6A)
None
GNP  B 200 (-3.9A)
 1.39A 4hytA-2qtvB:
2.8		 4hytA-2qtvB:
9.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYT_A_OBNA1104_2
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 4bzi SAR1P
(Saccharomyces
cerevisiae) 		4 / 5 ASP B  99
ASN B 132
ILE B 134
VAL B 174
 None
GNP  B1190 (-3.6A)
None
GNP  B1190 (-3.9A)
 1.39A 4hytA-4bziB:
2.5		 4hytA-4bziB:
10.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IJI_F_BEZF501_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN YIBF)		 1x3s RAS-RELATED PROTEIN
RAB-18
(Homo
sapiens) 		4 / 8 ASN A 122
ALA A 150
SER A 151
LEU A  24
 GNP  A 300 (-3.2A)
None
GNP  A 300 (-3.4A)
None
 1.19A 4ijiF-1x3sA:
undetectable		 4ijiF-1x3sA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYK_B_IMNB300_1
(LACTOYLGLUTATHIONE
LYASE)		 1r4a ADP-RIBOSYLATION
FACTOR-LIKE PROTEIN
1
(Rattus
norvegicus) 		5 / 12 ALA A 109
MET A 110
LEU A 143
LYS A  30
GLY A  70
 None
None
None
GNP  A1201 (-2.9A)
GNP  A1201 (-3.9A)
 1.29A 4kykA-1r4aA:
0.2
4kykB-1r4aA:
0.4		 4kykA-1r4aA:
22.66
4kykB-1r4aA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L9I_B_8PRB601_1
(RHODOPSIN KINASE)		 1wf3 GTP-BINDING PROTEIN
(Thermus
thermophilus) 		5 / 8 GLY A  19
ALA A 136
MET A 137
ASP A 128
LEU A 127
 GNP  A 501 (-3.4A)
None
None
GNP  A 501 (-2.9A)
None
 1.45A 4l9iB-1wf3A:
undetectable		 4l9iB-1wf3A:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MK4_A_CHDA503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5ady GTPASE HFLX
(Escherichia
coli) 		5 / 10 LEU 6 357
LEU 6 353
LEU 6 342
ARG 6 360
THR 6 212
 None
None
None
None
GNP  6 527 (-3.2A)
 1.36A 4mk4A-5ady6:
3.7		 4mk4A-5ady6:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM4_B_8PRB603_2
(TRANSPORTER)		 1f5n INTERFERON-INDUCED
GUANYLATE-BINDING
PROTEIN 1
(Homo
sapiens) 		3 / 3 SER A  52
MET A  55
ASP A 184
 MG  A 595 ( 2.2A)
None
GNP  A 593 (-2.9A)
 0.90A 4mm4B-1f5nA:
0.0		 4mm4B-1f5nA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1Z_B_MXMB807_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 3bh6 ADP-RIBOSYLATION
FACTOR-LIKE PROTEIN
3
(Mus
musculus) 		5 / 12 LEU A  37
ILE A  89
VAL A  91
LEU A  22
ALA A 160
 None
None
None
None
GNP  A   1 (-3.7A)
 1.01A 4o1zB-3bh6A:
undetectable		 4o1zB-3bh6A:
14.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OT2_A_NPSA602_1
(SERUM ALBUMIN)		 4lbw ELONGATION FACTOR
TU-A
(Thermus
thermophilus) 		4 / 6 ALA A  29
ASP A  81
LEU A 179
SER A 174
 None
MG  A 502 ( 4.0A)
None
GNP  A 501 (-2.7A)
 1.15A 4ot2A-4lbwA:
undetectable		 4ot2A-4lbwA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW0_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5)		 1z06 RAS-RELATED PROTEIN
RAB-33B
(Mus
musculus) 		4 / 7 THR A  62
ALA A  64
THR A  65
ALA A  90
 GNP  A 204 (-3.6A)
GNP  A 204 (-3.6A)
MG  A 203 ( 3.1A)
None
 0.97A 4qw0K-1z06A:
undetectable		 4qw0K-1z06A:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW0_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5)		 1z06 RAS-RELATED PROTEIN
RAB-33B
(Mus
musculus) 		4 / 7 THR A  62
ALA A  64
THR A  65
ALA A  90
 GNP  A 204 (-3.6A)
GNP  A 204 (-3.6A)
MG  A 203 ( 3.1A)
None
 0.97A 4qw0Y-1z06A:
undetectable		 4qw0Y-1z06A:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUC_A_SAMA303_1
(CATECHOL
O-METHYLTRANSFERASE)		 5wdr RAS PROTEIN
(Choanoflagellida) 		4 / 4 SER A  89
GLU A 144
SER A 146
ASP A  85
 None
None
GNP  A 203 (-3.5A)
None
 1.36A 4xucA-5wdrA:
3.0		 4xucA-5wdrA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0P_A_TE4A201_1
(BETA-LACTOGLOBULIN)		 3c5h GLUCOCORTICOID
RECEPTOR DNA-BINDING
FACTOR 1
(Homo
sapiens) 		5 / 12 LEU A 178
VAL A 181
LEU A  38
ILE A  33
VAL A 226
 None
None
None
GNP  A 301 (-4.3A)
None
 1.14A 4y0pA-3c5hA:
undetectable		 4y0pA-3c5hA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YOA_A_017A100_1
(HIV-1 PROTEASE)		 4lbw ELONGATION FACTOR
TU-A
(Thermus
thermophilus) 		4 / 6 ASN A 136
ASP A  21
THR A  16
VAL A 105
 GNP  A 501 (-3.2A)
GNP  A 501 (-3.4A)
None
None
 1.14A 4yoaA-4lbwA:
undetectable		 4yoaA-4lbwA:
15.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZXI_A_GLYA1402_0
(TYROCIDINE
SYNTHETASE 3)		 3bh6 ADP-RIBOSYLATION
FACTOR-LIKE PROTEIN
3
(Mus
musculus) 		4 / 7 ASP A  67
ILE A  68
GLY A  70
THR A  31
 MG  A   2 ( 4.0A)
None
GNP  A   1 (-3.4A)
MG  A   2 ( 3.2A)
 0.94A 4zxiA-3bh6A:
3.1		 4zxiA-3bh6A:
8.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZXI_A_GLYA1402_0
(TYROCIDINE
SYNTHETASE 3)		 5de3 ADP-RIBOSYLATION
FACTOR-LIKE PROTEIN
3
(Chlamydomonas
reinhardtii) 		4 / 7 ASP A  66
ILE A  67
GLY A  69
THR A  30
 MG  A 202 ( 4.1A)
None
GNP  A 201 (-3.7A)
MG  A 202 ( 3.1A)
 1.08A 4zxiA-5de3A:
3.6		 4zxiA-5de3A:
8.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CZY_A_SAMA603_0
(LEGIONELLA EFFECTOR
LEGAS4)		 2qtv SMALL COPII COAT
GTPASE SAR1
PROTEIN TRANSPORT
PROTEIN SEC31
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		5 / 12 LEU B  74
GLY B  75
SER D 908
TYR B  87
LEU B  27
 None
GNP  B 200 ( 4.0A)
None
None
None
 1.39A 5czyA-2qtvB:
undetectable		 5czyA-2qtvB:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EQB_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5l3s SIGNAL RECOGNITION
PARTICLE 54 KDA
PROTEIN
SIGNAL RECOGNITION
PARTICLE RECEPTOR
FTSY
(Sulfolobus
acidocaldarius;
Sulfolobus
solfataricus) 		5 / 12 GLY B 348
ILE A 244
GLY A 253
GLY A 255
HIS A 190
 GNP  B 401 (-3.4A)
None
None
None
GNP  B 401 (-4.4A)
 0.99A 5eqbA-5l3sB:
undetectable		 5eqbA-5l3sB:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FA8_A_SAMA301_1
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE,
PUTATIVE)		 5gad SIGNAL RECOGNITION
PARTICLE RECEPTOR
FTSY
(Escherichia
coli) 		3 / 3 THR l 356
ASP l 330
GLU l 396
 None
GNP  l1400 ( 4.7A)
None
 0.78A 5fa8A-5gadl:
undetectable		 5fa8A-5gadl:
15.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHR_A_SAMA303_1
(CATECHOL
O-METHYLTRANSFERASE)		 5wdr RAS PROTEIN
(Choanoflagellida) 		4 / 5 SER A  89
GLU A 144
SER A 146
ASP A  85
 None
None
GNP  A 203 (-3.5A)
None
 1.37A 5fhrA-5wdrA:
undetectable		 5fhrA-5wdrA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHR_B_SAMB303_1
(CATECHOL
O-METHYLTRANSFERASE)		 5wdr RAS PROTEIN
(Choanoflagellida) 		4 / 5 SER A  89
GLU A 144
SER A 146
ASP A  85
 None
None
GNP  A 203 (-3.5A)
None
 1.37A 5fhrB-5wdrA:
undetectable		 5fhrB-5wdrA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GQB_A_GCSA605_1
(CHITINASE)		 6ces RAS-RELATED
GTP-BINDING PROTEIN
A
(Homo
sapiens) 		3 / 3 TRP A 165
ILE A  26
SER A  22
 GNP  A 500 (-4.6A)
None
GNP  A 500 (-4.4A)
 0.92A 5gqbA-6cesA:
3.7		 5gqbA-6cesA:
9.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIK_A_SAMA301_0
(GLYCINE SARCOSINE
N-METHYLTRANSFERASE)		 3tso RAS-RELATED PROTEIN
RAB-25
(Homo
sapiens) 		5 / 12 GLY A  24
GLY A  70
SER A  21
ARG A 105
GLY A 124
 GNP  A 201 (-3.2A)
GNP  A 201 (-3.8A)
GNP  A 201 (-2.4A)
None
None
 1.16A 5hikA-3tsoA:
2.5		 5hikA-3tsoA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HNW_B_TA1B902_1
(TUBULIN BETA-2B
CHAIN)		 3ryt RAS-RELATED C3
BOTULINUM TOXIN
SUBSTRATE 1
(Homo
sapiens) 		5 / 12 VAL C 101
LEU C  19
LEU C  79
LEU C  20
THR C  17
 None
None
None
None
GNP  C 179 ( 3.6A)
 1.18A 5hnwB-3rytC:
undetectable		 5hnwB-3rytC:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HRQ_G_IPHG101_0
(INSULIN A-CHAIN
INSULIN B-CHAIN)		 3r7w GTP-BINDING PROTEIN
GTR2
(Saccharomyces
cerevisiae) 		4 / 6 HIS B 124
LEU B 122
CYH B  26
LEU B  14
 GNP  B 500 (-3.7A)
None
None
None
 1.40A 5hrqD-3r7wB:
undetectable
5hrqG-3r7wB:
undetectable
5hrqH-3r7wB:
undetectable		 5hrqD-3r7wB:
5.54
5hrqG-3r7wB:
5.70
5hrqH-3r7wB:
5.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IMS_B_ACTB713_0
(ACETOLACTATE
SYNTHASE CATALYTIC
SUBUNIT,
MITOCHONDRIAL)		 5cb2 PROTEIN SEY1
(Candida
albicans) 		3 / 3 GLY A  65
GLN A 161
LYS A  71
 None
None
GNP  A 702 (-3.7A)
 0.92A 5imsB-5cb2A:
3.6		 5imsB-5cb2A:
21.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5IQB_A_KANA600_1
(BIFUNCTIONAL AAC/APH)		 6cey BIFUNCTIONAL AAC/APH
(Staphylococcus
aureus) 		11 / 12 ASP A 374
SER A 376
ASN A 378
ASP A 396
TYR A 408
GLU A 411
SER A 413
GLU A 416
GLU A 445
TYR A 448
GLU A 451
 GNP  A 500 (-4.6A)
None
None
MG  A 702 ( 4.8A)
None
None
None
None
None
None
None
 0.50A 5iqbA-6ceyA:
16.8		 5iqbA-6ceyA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5IQB_B_KANB600_1
(BIFUNCTIONAL AAC/APH)		 6cey BIFUNCTIONAL AAC/APH
(Staphylococcus
aureus) 		10 / 11 ASP A 374
SER A 376
ASN A 378
ASP A 396
TYR A 408
GLU A 411
GLU A 416
GLU A 445
TYR A 448
GLU A 451
 GNP  A 500 (-4.6A)
None
None
MG  A 702 ( 4.8A)
None
None
None
None
None
None
 0.53A 5iqbB-6ceyA:
43.1		 5iqbB-6ceyA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5IQB_C_KANC600_1
(BIFUNCTIONAL AAC/APH)		 6cey BIFUNCTIONAL AAC/APH
(Staphylococcus
aureus) 		10 / 11 ASP A 374
SER A 376
ASN A 378
ASP A 396
TYR A 408
GLU A 411
GLU A 416
GLU A 445
TYR A 448
GLU A 451
 GNP  A 500 (-4.6A)
None
None
MG  A 702 ( 4.8A)
None
None
None
None
None
None
 0.48A 5iqbC-6ceyA:
43.2		 5iqbC-6ceyA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5IQB_D_KAND600_1
(BIFUNCTIONAL AAC/APH)		 6cey BIFUNCTIONAL AAC/APH
(Staphylococcus
aureus) 		11 / 12 ASP A 374
SER A 376
ASN A 378
ASP A 396
TYR A 408
GLU A 411
SER A 413
GLU A 416
GLU A 445
TYR A 448
GLU A 451
 GNP  A 500 (-4.6A)
None
None
MG  A 702 ( 4.8A)
None
None
None
None
None
None
None
 0.60A 5iqbD-6ceyA:
41.4		 5iqbD-6ceyA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5IQC_A_51GA600_1
(BIFUNCTIONAL AAC/APH)		 6cey BIFUNCTIONAL AAC/APH
(Staphylococcus
aureus) 		8 / 10 ASP A 374
SER A 376
ASP A 396
TYR A 408
GLU A 411
GLU A 416
TYR A 448
GLU A 451
 GNP  A 500 (-4.6A)
None
MG  A 702 ( 4.8A)
None
None
None
None
None
 0.44A 5iqcA-6ceyA:
43.2		 5iqcA-6ceyA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5IQC_B_51GB600_1
(BIFUNCTIONAL AAC/APH)		 6cey BIFUNCTIONAL AAC/APH
(Staphylococcus
aureus) 		8 / 10 ASP A 374
SER A 376
ASP A 396
TYR A 408
GLU A 411
GLU A 416
TYR A 448
GLU A 451
 GNP  A 500 (-4.6A)
None
MG  A 702 ( 4.8A)
None
None
None
None
None
 0.46A 5iqcB-6ceyA:
42.7		 5iqcB-6ceyA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5IQC_C_51GC600_1
(BIFUNCTIONAL AAC/APH)		 6cey BIFUNCTIONAL AAC/APH
(Staphylococcus
aureus) 		8 / 10 ASP A 374
SER A 376
ASP A 396
TYR A 408
GLU A 411
GLU A 416
TYR A 448
GLU A 451
 GNP  A 500 (-4.6A)
None
MG  A 702 ( 4.8A)
None
None
None
None
None
 0.31A 5iqcC-6ceyA:
43.3		 5iqcC-6ceyA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5IQC_D_51GD600_1
(BIFUNCTIONAL AAC/APH)		 6cey BIFUNCTIONAL AAC/APH
(Staphylococcus
aureus) 		8 / 10 ASP A 374
SER A 376
ASP A 396
TYR A 408
GLU A 411
GLU A 416
TYR A 448
GLU A 451
 GNP  A 500 (-4.6A)
None
MG  A 702 ( 4.8A)
None
None
None
None
None
 0.54A 5iqcD-6ceyA:
41.6		 5iqcD-6ceyA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5IQC_D_51GD600_1
(BIFUNCTIONAL AAC/APH)		 6cey BIFUNCTIONAL AAC/APH
(Staphylococcus
aureus) 		6 / 10 ASP A 374
SER A 376
TYR A 408
GLU A 411
GLU A 416
GLU A 445
 GNP  A 500 (-4.6A)
None
None
None
None
None
 0.77A 5iqcD-6ceyA:
41.6		 5iqcD-6ceyA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IQD_A_RIOA600_0
(BIFUNCTIONAL AAC/APH)		 6cey BIFUNCTIONAL AAC/APH
(Staphylococcus
aureus) 		9 / 11 ASP A 374
SER A 376
TYR A 408
GLU A 411
SER A 413
GLU A 416
VAL A 444
TYR A 448
GLU A 451
 GNP  A 500 (-4.6A)
None
None
None
None
None
None
None
None
 0.31A 5iqdA-6ceyA:
16.7		 5iqdA-6ceyA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IQD_B_RIOB600_0
(BIFUNCTIONAL AAC/APH)		 6cey BIFUNCTIONAL AAC/APH
(Staphylococcus
aureus) 		9 / 11 ASP A 374
SER A 376
TYR A 408
GLU A 411
SER A 413
GLU A 416
VAL A 444
TYR A 448
GLU A 451
 GNP  A 500 (-4.6A)
None
None
None
None
None
None
None
None
 0.39A 5iqdB-6ceyA:
42.7		 5iqdB-6ceyA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IQD_C_RIOC600_0
(BIFUNCTIONAL AAC/APH)		 6cey BIFUNCTIONAL AAC/APH
(Staphylococcus
aureus) 		10 / 12 ASP A 374
SER A 376
ASN A 378
TYR A 408
GLU A 411
SER A 413
GLU A 416
VAL A 444
TYR A 448
GLU A 451
 GNP  A 500 (-4.6A)
None
None
None
None
None
None
None
None
None
 0.29A 5iqdC-6ceyA:
18.1		 5iqdC-6ceyA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IQD_D_RIOD600_0
(BIFUNCTIONAL AAC/APH)		 6cey BIFUNCTIONAL AAC/APH
(Staphylococcus
aureus) 		8 / 11 ASP A 374
SER A 376
TYR A 408
GLU A 411
SER A 413
GLU A 416
VAL A 444
GLU A 445
 GNP  A 500 (-4.6A)
None
None
None
None
None
None
None
 0.69A 5iqdD-6ceyA:
42.8		 5iqdD-6ceyA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IQD_D_RIOD600_0
(BIFUNCTIONAL AAC/APH)		 6cey BIFUNCTIONAL AAC/APH
(Staphylococcus
aureus) 		9 / 11 ASP A 374
SER A 376
TYR A 408
GLU A 411
SER A 413
GLU A 416
VAL A 444
TYR A 448
GLU A 451
 GNP  A 500 (-4.6A)
None
None
None
None
None
None
None
None
 0.49A 5iqdD-6ceyA:
42.8		 5iqdD-6ceyA:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5IQE_A_NMYA600_1
(BIFUNCTIONAL AAC/APH)		 6cey BIFUNCTIONAL AAC/APH
(Staphylococcus
aureus) 		9 / 11 ASP A 374
SER A 376
ASP A 396
TYR A 408
GLU A 411
SER A 413
GLU A 416
TYR A 448
GLU A 451
 GNP  A 500 (-4.6A)
None
MG  A 702 ( 4.8A)
None
None
None
None
None
None
 0.27A 5iqeA-6ceyA:
44.0		 5iqeA-6ceyA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5IQE_B_NMYB600_1
(BIFUNCTIONAL AAC/APH)		 6cey BIFUNCTIONAL AAC/APH
(Staphylococcus
aureus) 		8 / 10 ASP A 374
SER A 376
ASP A 396
TYR A 408
GLU A 411
GLU A 416
TYR A 448
GLU A 451
 GNP  A 500 (-4.6A)
None
MG  A 702 ( 4.8A)
None
None
None
None
None
 0.37A 5iqeB-6ceyA:
43.2		 5iqeB-6ceyA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5IQE_C_NMYC600_1
(BIFUNCTIONAL AAC/APH)		 6cey BIFUNCTIONAL AAC/APH
(Staphylococcus
aureus) 		11 / 12 ASP A 374
SER A 376
ASN A 378
ASP A 396
TYR A 408
GLU A 411
SER A 413
GLU A 415
GLU A 416
TYR A 448
GLU A 451
 GNP  A 500 (-4.6A)
None
None
MG  A 702 ( 4.8A)
None
None
None
None
None
None
None
 0.46A 5iqeC-6ceyA:
34.3		 5iqeC-6ceyA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5IQE_D_NMYD600_1
(BIFUNCTIONAL AAC/APH)		 6cey BIFUNCTIONAL AAC/APH
(Staphylococcus
aureus) 		9 / 12 ASP A 374
SER A 376
ASN A 378
ASP A 396
TYR A 408
GLU A 411
SER A 413
GLU A 416
GLU A 445
 GNP  A 500 (-4.6A)
None
None
MG  A 702 ( 4.8A)
None
None
None
None
None
 0.54A 5iqeD-6ceyA:
41.9		 5iqeD-6ceyA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5IQE_D_NMYD600_1
(BIFUNCTIONAL AAC/APH)		 6cey BIFUNCTIONAL AAC/APH
(Staphylococcus
aureus) 		10 / 12 ASP A 374
SER A 376
ASN A 378
ASP A 396
TYR A 408
GLU A 411
SER A 413
GLU A 416
TYR A 448
GLU A 451
 GNP  A 500 (-4.6A)
None
None
MG  A 702 ( 4.8A)
None
None
None
None
None
None
 0.60A 5iqeD-6ceyA:
41.9		 5iqeD-6ceyA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5IQG_A_51GA600_1
(BIFUNCTIONAL AAC/APH)		 6cey BIFUNCTIONAL AAC/APH
(Staphylococcus
aureus) 		8 / 10 ASP A 374
SER A 376
ASP A 396
TYR A 408
GLU A 411
GLU A 416
TYR A 448
GLU A 451
 GNP  A 500 (-4.6A)
None
MG  A 702 ( 4.8A)
None
None
None
None
None
 0.36A 5iqgA-6ceyA:
42.4		 5iqgA-6ceyA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5IQG_B_51GB600_1
(BIFUNCTIONAL AAC/APH)		 6cey BIFUNCTIONAL AAC/APH
(Staphylococcus
aureus) 		8 / 10 ASP A 374
SER A 376
ASP A 396
TYR A 408
GLU A 411
GLU A 416
TYR A 448
GLU A 451
 GNP  A 500 (-4.6A)
None
MG  A 702 ( 4.8A)
None
None
None
None
None
 0.41A 5iqgB-6ceyA:
42.2		 5iqgB-6ceyA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5IQG_C_51GC600_1
(BIFUNCTIONAL AAC/APH)		 6cey BIFUNCTIONAL AAC/APH
(Staphylococcus
aureus) 		5 / 10 ASP A 374
SER A 376
ASP A 396
GLU A 411
GLU A 416
 GNP  A 500 (-4.6A)
None
MG  A 702 ( 4.8A)
None
None
 1.39A 5iqgC-6ceyA:
42.8		 5iqgC-6ceyA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5IQG_C_51GC600_1
(BIFUNCTIONAL AAC/APH)		 6cey BIFUNCTIONAL AAC/APH
(Staphylococcus
aureus) 		8 / 10 ASP A 374
SER A 376
ASP A 396
TYR A 408
GLU A 411
GLU A 416
TYR A 448
GLU A 451
 GNP  A 500 (-4.6A)
None
MG  A 702 ( 4.8A)
None
None
None
None
None
 0.33A 5iqgC-6ceyA:
42.8		 5iqgC-6ceyA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5IQG_D_51GD600_1
(BIFUNCTIONAL AAC/APH)		 6cey BIFUNCTIONAL AAC/APH
(Staphylococcus
aureus) 		8 / 10 ASP A 374
SER A 376
ASP A 396
TYR A 408
GLU A 411
GLU A 416
TYR A 448
GLU A 451
 GNP  A 500 (-4.6A)
None
MG  A 702 ( 4.8A)
None
None
None
None
None
 0.49A 5iqgD-6ceyA:
16.3		 5iqgD-6ceyA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J4N_B_AG2B501_1
(ARGININE/AGMATINE
ANTIPORTER)		 4rkf RAS-RELATED PROTEIN
RAB-3
(Drosophila
melanogaster) 		4 / 6 ILE A  74
GLY A  33
ASN A 134
MET A 100
 None
GNP  A 201 (-3.2A)
GNP  A 201 (-3.3A)
None
 0.98A 5j4nB-4rkfA:
undetectable		 5j4nB-4rkfA:
17.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_A_1GNA615_1
(PHIAB6 TAILSPIKE)		 3a58 GTP-BINDING PROTEIN
RHO1
(Saccharomyces
cerevisiae) 		3 / 3 TYR B  39
TYR B  71
GLN B  68
 GNP  B 301 (-4.4A)
None
None
 1.08A 5jsdA-3a58B:
undetectable
5jsdB-3a58B:
undetectable		 5jsdA-3a58B:
12.64
5jsdB-3a58B:
12.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_A_1GNA615_1
(PHIAB6 TAILSPIKE)		 5wdr RAS PROTEIN
(Choanoflagellida) 		3 / 3 TYR A  32
TYR A  64
GLN A  61
 GNP  A 203 (-3.2A)
None
GNP  A 203 ( 4.5A)
 1.17A 5jsdA-5wdrA:
undetectable
5jsdB-5wdrA:
undetectable		 5jsdA-5wdrA:
13.22
5jsdB-5wdrA:
13.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_B_1GNB606_1
(PHIAB6 TAILSPIKE)		 3a58 GTP-BINDING PROTEIN
RHO1
(Saccharomyces
cerevisiae) 		3 / 3 TYR B  39
TYR B  71
GLN B  68
 GNP  B 301 (-4.4A)
None
None
 1.07A 5jsdB-3a58B:
undetectable
5jsdC-3a58B:
undetectable		 5jsdB-3a58B:
12.64
5jsdC-3a58B:
12.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_B_1GNB606_1
(PHIAB6 TAILSPIKE)		 5wdr RAS PROTEIN
(Choanoflagellida) 		3 / 3 TYR A  32
TYR A  64
GLN A  61
 GNP  A 203 (-3.2A)
None
GNP  A 203 ( 4.5A)
 1.17A 5jsdB-5wdrA:
undetectable
5jsdC-5wdrA:
undetectable		 5jsdB-5wdrA:
13.22
5jsdC-5wdrA:
13.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K4P_A_SORA611_0
(PROBABLE
PHOSPHATIDYLETHANOLA
MINE TRANSFERASE
MCR-1)		 5l3q SIGNAL RECOGNITION
PARTICLE RECEPTOR
SUBUNIT ALPHA
(Homo
sapiens) 		4 / 6 GLY B 615
THR B 588
GLY B 551
ASN B 434
 GNP  B 705 (-3.6A)
GNP  B 705 ( 4.6A)
None
GNP  B 705 (-3.7A)
 0.83A 5k4pA-5l3qB:
4.6		 5k4pA-5l3qB:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KOC_A_SAMA401_0
(PAVINE
N-METHYLTRANSFERASE)		 1x3s RAS-RELATED PROTEIN
RAB-18
(Homo
sapiens) 		5 / 12 GLY A 157
ASN A 122
ASP A  89
VAL A  90
THR A  91
 None
GNP  A 300 (-3.2A)
None
None
None
 0.84A 5kocA-1x3sA:
undetectable		 5kocA-1x3sA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KPC_B_SAMB401_0
(PAVINE
N-METHYLTRANSFERASE)		 1x3s RAS-RELATED PROTEIN
RAB-18
(Homo
sapiens) 		5 / 12 GLY A 157
ASN A 122
ASP A  89
VAL A  90
THR A  91
 None
GNP  A 300 (-3.2A)
None
None
None
 0.92A 5kpcB-1x3sA:
undetectable		 5kpcB-1x3sA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_I_Z80I401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 4m9q ARF-LIKE GTPASE
(Chlamydomonas
reinhardtii) 		4 / 9 ILE A  39
VAL A  91
ASN A 128
ASP A 170
 None
None
GNP  A 301 (-3.3A)
None
 0.98A 5lg3I-4m9qA:
undetectable		 5lg3I-4m9qA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_I_Z80I401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 5di3 ADP-RIBOSYLATION
FACTOR-LIKE PROTEIN
13B
(Chlamydomonas
reinhardtii) 		4 / 9 ILE B  39
VAL B  91
ASN B 128
ASP B 170
 None
None
GNP  B 301 (-3.2A)
None
 1.04A 5lg3I-5di3B:
undetectable		 5lg3I-5di3B:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NFJ_A_SAMA501_0
(MITOCHONDRIAL
RIBONUCLEASE P
PROTEIN 1)		 1gl6 ATPASE
(Escherichia
coli) 		5 / 12 ILE A 467
GLY A 415
THR A 132
LEU A 410
MET A 426
 None
None
GNP  A 701 (-4.7A)
None
None
 0.91A 5nfjA-1gl6A:
undetectable		 5nfjA-1gl6A:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODI_A_ACTA701_0
(HETERODISULFIDE
REDUCTASE, SUBUNIT A)		 1ek0 PROTEIN (GTP-BINDING
PROTEIN YPT51)
(Saccharomyces
cerevisiae) 		3 / 3 LYS A  36
LYS A  20
SER A  21
 None
GNP  A 501 (-2.7A)
MG  A 601 ( 2.0A)
 1.45A 5odiA-1ek0A:
2.2		 5odiA-1ek0A:
16.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T2Z_B_017B201_2
(PROTEASE)		 1yvd RAS-RELATED PROTEIN
RAB-22A
(Mus
musculus) 		5 / 12 GLY A 117
ALA A 116
GLY A  12
SER A  20
ILE A  21
 None
None
None
GNP  A 900 (-2.8A)
None
 0.81A 5t2zB-1yvdA:
undetectable		 5t2zB-1yvdA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T2Z_B_017B201_2
(PROTEASE)		 2fg5 RAS-RELATED PROTEIN
RAB-31
(Homo
sapiens) 		5 / 12 GLY A 117
ALA A 116
GLY A  12
SER A  20
ILE A  21
 None
None
None
GNP  A 302 (-2.7A)
None
 0.79A 5t2zB-2fg5A:
undetectable		 5t2zB-2fg5A:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUD_A_ERMA2001_2
(5-HYDROXYTRYPTAMINE
RECEPTOR 2B,SOLUBLE
CYTOCHROME B562
CHIMERA)		 5cb2 PROTEIN SEY1
(Candida
albicans) 		4 / 7 THR A  69
LEU A 172
GLN A 315
GLU A 134
 GNP  A 702 (-4.4A)
None
None
None
 1.09A 5tudA-5cb2A:
4.8		 5tudA-5cb2A:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC1_A_486A801_1
(GLUCOCORTICOID
RECEPTOR)		 4bzi SAR1P
SEC23P
(Saccharomyces
cerevisiae) 		5 / 12 LEU B  83
LEU B  74
GLY B  75
GLY B  76
CYH A 349
 None
None
GNP  B1190 ( 4.0A)
GNP  B1190 (-3.2A)
None
 1.05A 5uc1A-4bziB:
undetectable		 5uc1A-4bziB:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC1_B_486B801_2
(GLUCOCORTICOID
RECEPTOR)		 4bzi SAR1P
SEC23P
(Saccharomyces
cerevisiae) 		5 / 12 LEU B  83
LEU B  74
GLY B  75
GLY B  76
CYH A 349
 None
None
GNP  B1190 ( 4.0A)
GNP  B1190 (-3.2A)
None
 1.02A 5uc1B-4bziB:
undetectable		 5uc1B-4bziB:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V1S_B_SAMB604_0
(RADICAL SAM)		 3oes GTPASE RHEBL1
(Homo
sapiens) 		5 / 9 LEU A 123
GLU A 128
SER A  92
VAL A  84
SER A  21
 GNP  A 201 (-4.2A)
None
None
None
GNP  A 201 (-2.6A)
 1.49A 5v1sB-3oesA:
3.1		 5v1sB-3oesA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_E_CVIE301_1
(REGULATORY PROTEIN
TETR)		 5wdr RAS PROTEIN
(Choanoflagellida) 		4 / 7 GLY A 115
GLN A  88
ASP A  85
ASP A 119
 None
None
None
GNP  A 203 (-2.0A)
 1.12A 5vlmE-5wdrA:
undetectable		 5vlmE-5wdrA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WGQ_A_ESTA601_1
(ESTROGEN RECEPTOR)		 2q3f RAS-RELATED
GTP-BINDING PROTEIN
D
(Homo
sapiens) 		5 / 9 ALA A 135
GLU A 134
LEU A  51
GLY A  55
HIS A 160
 None
None
None
GNP  A 401 (-3.3A)
GNP  A 401 (-3.5A)
 1.49A 5wgqA-2q3fA:
undetectable		 5wgqA-2q3fA:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_A_SAMA901_0
(MRNA CAPPING ENZYME
P5)		 5wdr RAS PROTEIN
(Choanoflagellida) 		5 / 11 VAL A 114
GLY A 115
SER A 146
ALA A 156
LEU A  79
 None
None
GNP  A 203 (-3.5A)
None
None
 1.23A 5x6yA-5wdrA:
2.0		 5x6yA-5wdrA:
12.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_A_SAMA901_0
(MRNA CAPPING ENZYME
P5)		 6f76 -
(-) 		5 / 11 VAL B 114
GLY B 115
SER B 145
ALA B 155
LEU B  79
 None
None
GNP  B 202 (-3.6A)
None
None
 1.23A 5x6yA-6f76B:
2.3		 5x6yA-6f76B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_C_SAMC901_0
(MRNA CAPPING ENZYME
P5)		 5wdr RAS PROTEIN
(Choanoflagellida) 		5 / 11 VAL A 114
GLY A 115
SER A 146
ALA A 156
LEU A  79
 None
None
GNP  A 203 (-3.5A)
None
None
 1.24A 5x6yC-5wdrA:
undetectable		 5x6yC-5wdrA:
12.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_C_SAMC901_0
(MRNA CAPPING ENZYME
P5)		 6f76 -
(-) 		5 / 11 VAL B 114
GLY B 115
SER B 145
ALA B 155
LEU B  79
 None
None
GNP  B 202 (-3.6A)
None
None
 1.24A 5x6yC-6f76B:
undetectable		 5x6yC-6f76B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y9M_X_NIOX401_1
(CASEIN KINASE II
SUBUNIT ALPHA')		 4jr7 CASEIN KINASE II
SUBUNIT ALPHA
(Saccharomyces
cerevisiae) 		6 / 8 VAL A  54
VAL A  67
LYS A  69
MET A 202
ILE A 213
ASP A 214
 GNP  A 401 (-4.2A)
GNP  A 401 (-4.8A)
GNP  A 401 (-3.3A)
GNP  A 401 (-3.6A)
GNP  A 401 (-4.6A)
GNP  A 401 ( 2.7A)
 0.62A 5y9mX-4jr7A:
45.1		 5y9mX-4jr7A:
11.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y9M_X_NIOX401_1
(CASEIN KINASE II
SUBUNIT ALPHA')		 4jr7 CASEIN KINASE II
SUBUNIT ALPHA
(Saccharomyces
cerevisiae) 		6 / 8 VAL A  54
VAL A  67
LYS A  69
PHE A 152
ILE A 213
ASP A 214
 GNP  A 401 (-4.2A)
GNP  A 401 (-4.8A)
GNP  A 401 (-3.3A)
None
GNP  A 401 (-4.6A)
GNP  A 401 ( 2.7A)
 0.29A 5y9mX-4jr7A:
45.1		 5y9mX-4jr7A:
11.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YF9_B_NIOB401_1
(CASEIN KINASE II
SUBUNIT ALPHA')		 4jr7 CASEIN KINASE II
SUBUNIT ALPHA
(Saccharomyces
cerevisiae) 		7 / 7 VAL A  54
VAL A  67
LYS A  69
PHE A 152
MET A 202
ILE A 213
ASP A 214
 GNP  A 401 (-4.2A)
GNP  A 401 (-4.8A)
GNP  A 401 (-3.3A)
None
GNP  A 401 (-3.6A)
GNP  A 401 (-4.6A)
GNP  A 401 ( 2.7A)
 0.64A 5yf9B-4jr7A:
44.7		 5yf9B-4jr7A:
11.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YF9_X_NIOX401_1
(CASEIN KINASE II
SUBUNIT ALPHA')		 4jr7 CASEIN KINASE II
SUBUNIT ALPHA
(Saccharomyces
cerevisiae) 		8 / 9 VAL A  54
VAL A  67
LYS A  69
ILE A 134
PHE A 152
MET A 202
ILE A 213
ASP A 214
 GNP  A 401 (-4.2A)
GNP  A 401 (-4.8A)
GNP  A 401 (-3.3A)
None
None
GNP  A 401 (-3.6A)
GNP  A 401 (-4.6A)
GNP  A 401 ( 2.7A)
 0.60A 5yf9X-4jr7A:
44.6		 5yf9X-4jr7A:
11.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YNI_A_SAMA401_0
(NSP16 PROTEIN)		 5xkt UREASE ACCESSORY
PROTEIN UREG
(Klebsiella
pneumoniae) 		5 / 12 GLY A 107
ASN A 151
ASP A 127
LEU A 155
ASP A 154
 GNP  A 301 ( 3.8A)
GNP  A 301 (-3.2A)
None
GNP  A 301 ( 4.5A)
GNP  A 301 (-2.9A)
 1.21A 5yniA-5xktA:
undetectable		 5yniA-5xktA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YWM_X_NIOX403_0
(CASEIN KINASE II
SUBUNIT ALPHA')		 4jr7 CASEIN KINASE II
SUBUNIT ALPHA
(Saccharomyces
cerevisiae) 		7 / 7 VAL A  54
VAL A  67
LYS A  69
ILE A 134
PHE A 152
ILE A 213
ASP A 214
 GNP  A 401 (-4.2A)
GNP  A 401 (-4.8A)
GNP  A 401 (-3.3A)
None
None
GNP  A 401 (-4.6A)
GNP  A 401 ( 2.7A)
 0.31A 5ywmX-4jr7A:
44.5		 5ywmX-4jr7A:
11.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A7P_A_9SCA601_1
(SERUM ALBUMIN)		 5di3 ADP-RIBOSYLATION
FACTOR-LIKE PROTEIN
13B
(Chlamydomonas
reinhardtii) 		4 / 5 ASN B 128
VAL B  67
LEU B  58
SER B  38
 GNP  B 301 (-3.2A)
None
None
None
 1.30A 6a7pA-5di3B:
undetectable		 6a7pA-5di3B:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_A_ACRA609_0
(ALPHA-AMYLASE)		 3r7w GTP-BINDING PROTEIN
GTR1
(Saccharomyces
cerevisiae) 		4 / 7 LYS A 127
GLY A  16
ASP A  66
MET A  69
 GNP  A 500 (-3.6A)
GNP  A 500 (-3.8A)
None
None
 1.25A 6ag0A-3r7wA:
undetectable		 6ag0A-3r7wA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C5U_A_RIOA600_0
(BIFUNCTIONAL AAC/APH)		 6cey BIFUNCTIONAL AAC/APH
(Staphylococcus
aureus) 		8 / 10 ASP A 374
SER A 376
ASN A 378
TYR A 408
GLU A 411
SER A 413
GLU A 416
GLU A 445
 GNP  A 500 (-4.6A)
None
None
None
None
None
None
None
 0.65A 6c5uA-6ceyA:
43.5		 6c5uA-6ceyA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C5U_A_RIOA600_0
(BIFUNCTIONAL AAC/APH)		 6cey BIFUNCTIONAL AAC/APH
(Staphylococcus
aureus) 		8 / 10 ASP A 374
SER A 376
ASN A 378
TYR A 408
GLU A 411
SER A 413
GLU A 416
TYR A 448
 GNP  A 500 (-4.6A)
None
None
None
None
None
None
None
 0.26A 6c5uA-6ceyA:
43.5		 6c5uA-6ceyA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C5U_B_RIOB600_0
(BIFUNCTIONAL AAC/APH)		 6cey BIFUNCTIONAL AAC/APH
(Staphylococcus
aureus) 		7 / 9 ASP A 374
SER A 376
TYR A 408
GLU A 411
SER A 413
GLU A 416
GLU A 445
 GNP  A 500 (-4.6A)
None
None
None
None
None
None
 0.70A 6c5uB-6ceyA:
43.3		 6c5uB-6ceyA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C5U_B_RIOB600_0
(BIFUNCTIONAL AAC/APH)		 6cey BIFUNCTIONAL AAC/APH
(Staphylococcus
aureus) 		7 / 9 ASP A 374
SER A 376
TYR A 408
GLU A 411
SER A 413
GLU A 416
TYR A 448
 GNP  A 500 (-4.6A)
None
None
None
None
None
None
 0.28A 6c5uB-6ceyA:
43.3		 6c5uB-6ceyA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C5U_D_RIOD600_0
(BIFUNCTIONAL AAC/APH)		 6cey BIFUNCTIONAL AAC/APH
(Staphylococcus
aureus) 		8 / 10 ASP A 374
SER A 376
ASN A 378
TYR A 408
GLU A 411
SER A 413
GLU A 416
GLU A 445
 GNP  A 500 (-4.6A)
None
None
None
None
None
None
None
 0.60A 6c5uD-6ceyA:
42.4		 6c5uD-6ceyA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C5U_D_RIOD600_0
(BIFUNCTIONAL AAC/APH)		 6cey BIFUNCTIONAL AAC/APH
(Staphylococcus
aureus) 		8 / 10 ASP A 374
SER A 376
ASN A 378
TYR A 408
GLU A 411
SER A 413
GLU A 416
TYR A 448
 GNP  A 500 (-4.6A)
None
None
None
None
None
None
None
 0.47A 6c5uD-6ceyA:
42.4		 6c5uD-6ceyA:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6CGD_A_AKNA600_1
(BIFUNCTIONAL AAC/APH)		 6cey BIFUNCTIONAL AAC/APH
(Staphylococcus
aureus) 		9 / 10 GLY A 211
ASP A 374
ASP A 396
TYR A 408
GLU A 411
VAL A 444
GLU A 445
TYR A 448
GLU A 451
 GNP  A 500 ( 4.3A)
GNP  A 500 (-4.6A)
MG  A 702 ( 4.8A)
None
None
None
None
None
None
 0.28A 6cgdA-6ceyA:
43.8		 6cgdA-6ceyA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6CGD_A_AKNA600_1
(BIFUNCTIONAL AAC/APH)		 6cey BIFUNCTIONAL AAC/APH
(Staphylococcus
aureus) 		5 / 10 GLY A 211
ASP A 374
ASP A 396
TYR A 408
GLU A 416
 GNP  A 500 ( 4.3A)
GNP  A 500 (-4.6A)
MG  A 702 ( 4.8A)
None
None
 1.29A 6cgdA-6ceyA:
43.8		 6cgdA-6ceyA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6CGD_A_AKNA600_1
(BIFUNCTIONAL AAC/APH)		 6cey BIFUNCTIONAL AAC/APH
(Staphylococcus
aureus) 		5 / 10 GLY A 211
ASP A 396
VAL A 444
TYR A 448
GLU A 451
 GNP  A 500 ( 4.3A)
MG  A 702 ( 4.8A)
None
None
None
 1.27A 6cgdA-6ceyA:
43.8		 6cgdA-6ceyA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CGG_B_84GB600_0
(BIFUNCTIONAL AAC/APH)		 6cey BIFUNCTIONAL AAC/APH
(Staphylococcus
aureus) 		9 / 10 ASP A 374
SER A 376
ASN A 378
HIS A 379
TYR A 408
GLU A 411
GLU A 415
GLU A 416
GLU A 445
 GNP  A 500 (-4.6A)
None
None
MG  A 700 ( 3.2A)
None
None
None
None
None
 0.61A 6cggB-6ceyA:
43.0		 6cggB-6ceyA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CGG_B_84GB600_0
(BIFUNCTIONAL AAC/APH)		 6cey BIFUNCTIONAL AAC/APH
(Staphylococcus
aureus) 		9 / 10 ASP A 374
SER A 376
ASN A 378
HIS A 379
TYR A 408
GLU A 411
GLU A 415
GLU A 416
GLU A 451
 GNP  A 500 (-4.6A)
None
None
MG  A 700 ( 3.2A)
None
None
None
None
None
 0.30A 6cggB-6ceyA:
43.0		 6cggB-6ceyA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CGG_D_84GD600_0
(BIFUNCTIONAL AAC/APH)		 6cey BIFUNCTIONAL AAC/APH
(Staphylococcus
aureus) 		8 / 11 ASP A 374
SER A 376
ASN A 378
HIS A 379
TYR A 408
GLU A 411
GLU A 416
GLU A 445
 GNP  A 500 (-4.6A)
None
None
MG  A 700 ( 3.2A)
None
None
None
None
 0.54A 6cggD-6ceyA:
42.0		 6cggD-6ceyA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CGG_D_84GD600_0
(BIFUNCTIONAL AAC/APH)		 6cey BIFUNCTIONAL AAC/APH
(Staphylococcus
aureus) 		9 / 11 ASP A 374
SER A 376
ASN A 378
HIS A 379
TYR A 408
GLU A 411
GLU A 416
TYR A 448
GLU A 451
 GNP  A 500 (-4.6A)
None
None
MG  A 700 ( 3.2A)
None
None
None
None
None
 0.46A 6cggD-6ceyA:
42.0		 6cggD-6ceyA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EKZ_A_SNPA413_0
(AROMATIC
PEROXYGENASE)		 5xr6 RAS-RELATED PROTEIN
RABA1A
(Arabidopsis
thaliana) 		4 / 7 ASP A 159
GLY A 125
SER A 156
VAL A  95
 None
None
GNP  A 301 (-3.3A)
None
 0.97A 6ekzA-5xr6A:
undetectable		 6ekzA-5xr6A:
23.26