SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'GNG'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1PWY_E_AC2E290_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3iom PURINE NUCLEOSIDE
PHOSPHORYLASE
(Mycobacterium
tuberculosis) 		7 / 10 GLY A 122
GLU A 189
VAL A 205
GLY A 206
MET A 207
THR A 230
ASN A 231
 GNG  A 800 (-3.6A)
GNG  A 800 (-2.9A)
GNG  A 800 (-4.4A)
GNG  A 800 (-3.6A)
GNG  A 800 (-3.4A)
GNG  A 800 (-3.9A)
GNG  A 800 (-2.8A)
 0.52A 1pwyE-3iomA:
34.0		 1pwyE-3iomA:
38.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1PWY_E_AC2E290_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3iom PURINE NUCLEOSIDE
PHOSPHORYLASE
(Mycobacterium
tuberculosis) 		7 / 10 GLY A 122
GLU A 189
VAL A 205
GLY A 206
THR A 230
ASN A 231
HIS A 243
 GNG  A 800 (-3.6A)
GNG  A 800 (-2.9A)
GNG  A 800 (-4.4A)
GNG  A 800 (-3.6A)
GNG  A 800 (-3.9A)
GNG  A 800 (-2.8A)
GNG  A 800 (-3.3A)
 0.73A 1pwyE-3iomA:
34.0		 1pwyE-3iomA:
38.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1V3Q_E_2DIE290_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3iom PURINE NUCLEOSIDE
PHOSPHORYLASE
(Mycobacterium
tuberculosis) 		7 / 10 GLY A 122
GLU A 189
VAL A 205
GLY A 206
MET A 207
THR A 230
ASN A 231
 GNG  A 800 (-3.6A)
GNG  A 800 (-2.9A)
GNG  A 800 (-4.4A)
GNG  A 800 (-3.6A)
GNG  A 800 (-3.4A)
GNG  A 800 (-3.9A)
GNG  A 800 (-2.8A)
 0.37A 1v3qE-3iomA:
33.3		 1v3qE-3iomA:
38.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1V3Q_E_2DIE290_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3iom PURINE NUCLEOSIDE
PHOSPHORYLASE
(Mycobacterium
tuberculosis) 		7 / 10 GLY A 122
GLU A 189
VAL A 205
GLY A 206
THR A 230
ASN A 231
HIS A 243
 GNG  A 800 (-3.6A)
GNG  A 800 (-2.9A)
GNG  A 800 (-4.4A)
GNG  A 800 (-3.6A)
GNG  A 800 (-3.9A)
GNG  A 800 (-2.8A)
GNG  A 800 (-3.3A)
 0.59A 1v3qE-3iomA:
33.3		 1v3qE-3iomA:
38.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q9R_A_BEZA203_0
(PROTEIN OF UNKNOWN
FUNCTION)		 3iom PURINE NUCLEOSIDE
PHOSPHORYLASE
(Mycobacterium
tuberculosis) 		4 / 5 LEU A 232
GLY A 122
ILE A 194
ILE A 236
 None
GNG  A 800 (-3.6A)
None
None
 0.75A 2q9rA-3iomA:
undetectable		 2q9rA-3iomA:
23.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3E9R_A_ACTA700_0
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 3iom PURINE NUCLEOSIDE
PHOSPHORYLASE
(Mycobacterium
tuberculosis) 		6 / 6 GLY A 122
TYR A 188
GLU A 189
GLY A 206
MET A 207
ASN A 231
 GNG  A 800 (-3.6A)
GNG  A 800 (-4.6A)
GNG  A 800 (-2.9A)
GNG  A 800 (-3.6A)
GNG  A 800 (-3.4A)
GNG  A 800 (-2.8A)
 0.65A 3e9rA-3iomA:
32.3		 3e9rA-3iomA:
34.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3E9R_C_ACTC700_0
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 3iom PURINE NUCLEOSIDE
PHOSPHORYLASE
(Mycobacterium
tuberculosis) 		6 / 6 GLY A 122
TYR A 188
GLU A 189
GLY A 206
MET A 207
ASN A 231
 GNG  A 800 (-3.6A)
GNG  A 800 (-4.6A)
GNG  A 800 (-2.9A)
GNG  A 800 (-3.6A)
GNG  A 800 (-3.4A)
GNG  A 800 (-2.8A)
 0.65A 3e9rC-3iomA:
32.7		 3e9rC-3iomA:
34.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3F8W_A_ADNA300_1
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 3iom PURINE NUCLEOSIDE
PHOSPHORYLASE
(Mycobacterium
tuberculosis) 		12 / 12 SER A  36
TYR A  92
ALA A 120
GLY A 122
TYR A 188
GLU A 189
VAL A 205
GLY A 206
MET A 207
ASN A 231
HIS A 243
VAL A 246
 SO4  A 301 ( 2.2A)
None
GNG  A 800 (-3.3A)
GNG  A 800 (-3.6A)
GNG  A 800 (-4.6A)
GNG  A 800 (-2.9A)
GNG  A 800 (-4.4A)
GNG  A 800 (-3.6A)
GNG  A 800 (-3.4A)
GNG  A 800 (-2.8A)
GNG  A 800 (-3.3A)
GNG  A 800 (-4.2A)
 0.53A 3f8wA-3iomA:
33.6		 3f8wA-3iomA:
34.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3F8W_B_ADNB301_1
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 3iom PURINE NUCLEOSIDE
PHOSPHORYLASE
(Mycobacterium
tuberculosis) 		5 / 12 GLY A 206
TYR A 188
GLU A 189
GLY A 185
HIS A 243
 GNG  A 800 (-3.6A)
GNG  A 800 (-4.6A)
GNG  A 800 (-2.9A)
None
GNG  A 800 (-3.3A)
 1.30A 3f8wB-3iomA:
33.1		 3f8wB-3iomA:
34.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3F8W_B_ADNB301_1
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 3iom PURINE NUCLEOSIDE
PHOSPHORYLASE
(Mycobacterium
tuberculosis) 		12 / 12 SER A  36
HIS A  90
TYR A  92
GLY A 122
TYR A 188
GLU A 189
VAL A 205
GLY A 206
MET A 207
ASN A 231
HIS A 243
VAL A 246
 SO4  A 301 ( 2.2A)
SO4  A 301 (-3.3A)
None
GNG  A 800 (-3.6A)
GNG  A 800 (-4.6A)
GNG  A 800 (-2.9A)
GNG  A 800 (-4.4A)
GNG  A 800 (-3.6A)
GNG  A 800 (-3.4A)
GNG  A 800 (-2.8A)
GNG  A 800 (-3.3A)
GNG  A 800 (-4.2A)
 0.52A 3f8wB-3iomA:
33.1		 3f8wB-3iomA:
34.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3F8W_C_ADNC302_1
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 3iom PURINE NUCLEOSIDE
PHOSPHORYLASE
(Mycobacterium
tuberculosis) 		12 / 12 SER A  36
HIS A  90
TYR A  92
ALA A 120
GLY A 122
TYR A 188
GLU A 189
VAL A 205
GLY A 206
MET A 207
ASN A 231
VAL A 246
 SO4  A 301 ( 2.2A)
SO4  A 301 (-3.3A)
None
GNG  A 800 (-3.3A)
GNG  A 800 (-3.6A)
GNG  A 800 (-4.6A)
GNG  A 800 (-2.9A)
GNG  A 800 (-4.4A)
GNG  A 800 (-3.6A)
GNG  A 800 (-3.4A)
GNG  A 800 (-2.8A)
GNG  A 800 (-4.2A)
 0.49A 3f8wC-3iomA:
33.5		 3f8wC-3iomA:
34.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KM6_B_EAAB222_1
(GLUTATHIONE
S-TRANSFERASE P)		 3iom PURINE NUCLEOSIDE
PHOSPHORYLASE
(Mycobacterium
tuberculosis) 		5 / 9 TYR A 180
VAL A 205
GLN A 132
VAL A 246
GLY A 122
 None
GNG  A 800 (-4.4A)
None
GNG  A 800 (-4.2A)
GNG  A 800 (-3.6A)
 1.45A 3km6B-3iomA:
undetectable		 3km6B-3iomA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_A_SAMA901_0
(MRNA CAPPING ENZYME
P5)		 3iom PURINE NUCLEOSIDE
PHOSPHORYLASE
(Mycobacterium
tuberculosis) 		5 / 11 GLY A 206
SER A 227
ASP A 203
ALA A 202
LEU A 140
 GNG  A 800 (-3.6A)
None
None
None
None
 1.24A 5x6yA-3iomA:
undetectable		 5x6yA-3iomA:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIO_A_HFGA801_0
(PROLINE-TRNA
SYNTHETASE CLASS II
AARS (YBAK RNA
BINDING DOMAIN PLUS
TRNA SYNTHETASE))		 3iom PURINE NUCLEOSIDE
PHOSPHORYLASE
(Mycobacterium
tuberculosis) 		5 / 12 GLU A  93
PRO A 186
GLU A 189
THR A 230
GLY A 122
 None
None
GNG  A 800 (-2.9A)
GNG  A 800 (-3.9A)
GNG  A 800 (-3.6A)
 1.30A 5xioA-3iomA:
undetectable		 5xioA-3iomA:
19.00