SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'GN1'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YZQ_A_SAMA6075_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN PH1780)		 2yqh UDP-N-ACETYLGLUCOSAM
INE
PYROPHOSPHORYLASE
(Candida
albicans) 		5 / 12 ILE A 296
THR A 281
VAL A 283
ILE A 336
GLU A 309
 None
None
None
None
GN1  A1001 (-3.0A)
 1.31A 2yzqA-2yqhA:
undetectable		 2yzqA-2yqhA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AOD_A_MIYA2001_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 2yqh UDP-N-ACETYLGLUCOSAM
INE
PYROPHOSPHORYLASE
(Candida
albicans) 		4 / 8 PHE A 362
GLU A 309
ILE A 364
ALA A  56
 None
GN1  A1001 (-3.0A)
None
None
 0.76A 3aodA-2yqhA:
undetectable		 3aodA-2yqhA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BUP_B_SAMB500_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 2yqh UDP-N-ACETYLGLUCOSAM
INE
PYROPHOSPHORYLASE
(Candida
albicans) 		3 / 3 HIS A 363
GLU A 391
ASN A 227
 None
None
GN1  A1001 (-3.1A)
 1.01A 4bupB-2yqhA:
undetectable		 4bupB-2yqhA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LV9_A_20JA601_1
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 4rgg PUTATIVE PHAGE
STRUCTURAL PROTEIN
(Lactococcus
phage
1358) 		4 / 8 PHE A 240
ASP A 235
ALA A 292
SER A 291
 GN1  A 401 ( 4.3A)
None
GN1  A 401 (-3.6A)
GN1  A 401 (-3.0A)
 1.15A 4lv9A-4rggA:
undetectable
4lv9B-4rggA:
undetectable		 4lv9A-4rggA:
23.09
4lv9B-4rggA:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LV9_B_20JB601_1
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 4rgg PUTATIVE PHAGE
STRUCTURAL PROTEIN
(Lactococcus
phage
1358) 		4 / 7 PHE A 240
ASP A 235
ALA A 292
SER A 291
 GN1  A 401 ( 4.3A)
None
GN1  A 401 (-3.6A)
GN1  A 401 (-3.0A)
 1.16A 4lv9A-4rggA:
undetectable
4lv9B-4rggA:
undetectable		 4lv9A-4rggA:
23.09
4lv9B-4rggA:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MA7_A_P2ZA301_1
(MAJOR PRION PROTEIN)		 2qkx BIFUNCTIONAL PROTEIN
GLMU
(Mycobacterium
tuberculosis) 		4 / 8 VAL A  93
LEU A 210
ILE A 164
VAL A 224
 None
GN1  A 401 ( 4.9A)
None
None
 0.92A 4ma7A-2qkxA:
undetectable		 4ma7A-2qkxA:
14.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_C_6ZPC902_1
(GLUTAMATE RECEPTOR 2)		 4rgg PUTATIVE PHAGE
STRUCTURAL PROTEIN
(Lactococcus
phage
1358) 		4 / 7 SER A 202
ASP A 243
PRO A 242
PHE A 240
 None
None
None
GN1  A 401 ( 4.3A)
 1.26A 5l1fC-4rggA:
undetectable		 5l1fC-4rggA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WBV_A_SAMA402_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
KMT5B)		 2yqh UDP-N-ACETYLGLUCOSAM
INE
PYROPHOSPHORYLASE
(Candida
albicans) 		3 / 3 HIS A 363
GLU A 391
ASN A 227
 None
None
GN1  A1001 (-3.1A)
 0.94A 5wbvA-2yqhA:
undetectable		 5wbvA-2yqhA:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WBV_B_SAMB402_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
KMT5B)		 2yqh UDP-N-ACETYLGLUCOSAM
INE
PYROPHOSPHORYLASE
(Candida
albicans) 		3 / 3 HIS A 363
GLU A 391
ASN A 227
 None
None
GN1  A1001 (-3.1A)
 0.94A 5wbvB-2yqhA:
undetectable		 5wbvB-2yqhA:
18.31