SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'GMT'


List of Similar Pattern of Amino Acids


Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YJA_B_ESTB1550_1
(ESTROGEN RECEPTOR)
5d01 N-ACETYL-ALPHA-D-GLU
COSAMINYL L-MALATE
SYNTHASE

(Bacillus
subtilis)
5 / 12 ALA A 141
LEU A  97
ILE A 125
GLY A 122
LEU A 120
None
None
None
GMT  A 401 ( 4.0A)
None
1.22A 2yjaB-5d01A:
undetectable
2yjaB-5d01A:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J6P_B_TA1B502_1
(TUBULIN BETA CHAIN)
5d01 N-ACETYL-ALPHA-D-GLU
COSAMINYL L-MALATE
SYNTHASE

(Bacillus
subtilis)
5 / 12 VAL A 288
GLU A 283
LEU A 232
GLY A 301
LEU A 279
None
GMT  A 401 (-3.6A)
None
None
None
1.16A 3j6pB-5d01A:
undetectable
3j6pB-5d01A:
24.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PXM_B_ESTB2000_1
(ESTROGEN RECEPTOR)
5d01 N-ACETYL-ALPHA-D-GLU
COSAMINYL L-MALATE
SYNTHASE

(Bacillus
subtilis)
5 / 11 ALA A 141
LEU A  97
ILE A 125
GLY A 122
LEU A 120
None
None
None
GMT  A 401 ( 4.0A)
None
1.21A 4pxmB-5d01A:
undetectable
4pxmB-5d01A:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_B_29SB601_1
(ESTROGEN RECEPTOR)
5d01 N-ACETYL-ALPHA-D-GLU
COSAMINYL L-MALATE
SYNTHASE

(Bacillus
subtilis)
5 / 12 ALA A 141
LEU A  97
ILE A 125
GLY A 122
LEU A 120
None
None
None
GMT  A 401 ( 4.0A)
None
1.02A 4xi3B-5d01A:
undetectable
4xi3B-5d01A:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DXB_B_ESTB601_1
(ESTROGEN RECEPTOR)
5d01 N-ACETYL-ALPHA-D-GLU
COSAMINYL L-MALATE
SYNTHASE

(Bacillus
subtilis)
5 / 11 ALA A 141
LEU A  97
ILE A 125
GLY A 122
LEU A 120
None
None
None
GMT  A 401 ( 4.0A)
None
1.20A 5dxbB-5d01A:
undetectable
5dxbB-5d01A:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGZ_A_SPRA404_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)
5d01 N-ACETYL-ALPHA-D-GLU
COSAMINYL L-MALATE
SYNTHASE

(Bacillus
subtilis)
5 / 9 LEU A 290
ILE A 307
PHE A 285
VAL A 151
GLU A 356
None
None
None
GMT  A 401 (-4.3A)
None
1.44A 5igzA-5d01A:
undetectable
5igzA-5d01A:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OGC_B_TA1B601_1
(TUBULIN BETA CHAIN)
5d01 N-ACETYL-ALPHA-D-GLU
COSAMINYL L-MALATE
SYNTHASE

(Bacillus
subtilis)
5 / 12 VAL A 288
GLU A 283
LEU A 232
GLY A 301
LEU A 279
None
GMT  A 401 (-3.6A)
None
None
None
0.98A 5ogcB-5d01A:
3.1
5ogcB-5d01A:
24.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VNC_C_GCSC801_1
(GLYCOGEN [STARCH]
SYNTHASE ISOFORM 2)
5d01 N-ACETYL-ALPHA-D-GLU
COSAMINYL L-MALATE
SYNTHASE

(Bacillus
subtilis)
7 / 10 GLY A  16
HIS A 121
VAL A 151
ASN A 174
LYS A 212
GLU A 283
GLY A 286
GMT  A 401 (-3.4A)
GMT  A 401 (-3.8A)
GMT  A 401 (-4.3A)
GMT  A 401 (-3.4A)
GMT  A 401 ( 4.4A)
GMT  A 401 (-3.6A)
GMT  A 401 (-3.7A)
0.41A 5vncC-5d01A:
12.0
5vncC-5d01A:
11.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNE_A_ACRA602_1
(-)
5d01 N-ACETYL-ALPHA-D-GLU
COSAMINYL L-MALATE
SYNTHASE

(Bacillus
subtilis)
5 / 12 GLY A  15
GLY A  16
VAL A 151
ASN A 174
GLY A 286
GMT  A 401 ( 4.7A)
GMT  A 401 (-3.4A)
GMT  A 401 (-4.3A)
GMT  A 401 (-3.4A)
GMT  A 401 (-3.7A)
0.48A 6gneA-5d01A:
30.1
6gneA-5d01A:
26.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNE_B_ACRB602_1
(-)
5d01 N-ACETYL-ALPHA-D-GLU
COSAMINYL L-MALATE
SYNTHASE

(Bacillus
subtilis)
5 / 12 GLY A  15
GLY A  16
VAL A 151
ASN A 174
GLY A 286
GMT  A 401 ( 4.7A)
GMT  A 401 (-3.4A)
GMT  A 401 (-4.3A)
GMT  A 401 (-3.4A)
GMT  A 401 (-3.7A)
0.47A 6gneB-5d01A:
30.0
6gneB-5d01A:
26.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_2
(-)
5d01 N-ACETYL-ALPHA-D-GLU
COSAMINYL L-MALATE
SYNTHASE

(Bacillus
subtilis)
5 / 12 GLY A  16
HIS A 121
VAL A 151
GLU A 283
GLY A 286
GMT  A 401 (-3.4A)
GMT  A 401 (-3.8A)
GMT  A 401 (-4.3A)
GMT  A 401 (-3.6A)
GMT  A 401 (-3.7A)
0.43A 6gngA-5d01A:
28.6
6gngA-5d01A:
22.50