SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'GMP'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA501_1
(CYTOCHROME P450 2B4)		 2fqx MEMBRANE LIPOPROTEIN
TMPC
(Treponema
pallidum) 		4 / 7 LEU A 160
PHE A 161
GLY A 164
ILE A 322
 None
GMP  A 400 ( 4.8A)
None
None
 0.82A 2bdmA-2fqxA:
undetectable		 2bdmA-2fqxA:
19.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2FQY_A_ADNA400_1
(MEMBRANE LIPOPROTEIN
TMPC)		 2fqx MEMBRANE LIPOPROTEIN
TMPC
(Treponema
pallidum) 		12 / 12 ASP A  27
PHE A  36
ASN A  37
GLY A  85
ASP A 108
MET A 158
PHE A 161
PHE A 186
GLY A 212
VAL A 237
ASP A 238
LYS A 260
 GMP  A 400 (-2.9A)
GMP  A 400 (-3.8A)
GMP  A 400 (-3.3A)
GMP  A 400 ( 3.7A)
GMP  A 400 (-3.3A)
GMP  A 400 (-3.5A)
GMP  A 400 ( 4.8A)
GMP  A 400 (-3.4A)
GMP  A 400 (-3.3A)
GMP  A 400 (-4.7A)
GMP  A 400 (-2.9A)
GMP  A 400 (-2.8A)
 0.73A 2fqyA-2fqxA:
54.3		 2fqyA-2fqxA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QE6_A_SAMA400_0
(UNCHARACTERIZED
PROTEIN TFU_2867)		 2fqx MEMBRANE LIPOPROTEIN
TMPC
(Treponema
pallidum) 		5 / 12 ALA A 292
GLY A 123
GLY A 287
ASP A 108
GLY A 127
 None
None
None
GMP  A 400 (-3.3A)
None
 0.88A 2qe6A-2fqxA:
undetectable		 2qe6A-2fqxA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_A_30BA500_1
(GENOME POLYPROTEIN)		 2fqx MEMBRANE LIPOPROTEIN
TMPC
(Treponema
pallidum) 		5 / 12 ASP A 238
GLY A 123
ALA A 262
ALA A 265
ASP A 263
 GMP  A 400 (-2.9A)
None
None
None
None
 1.12A 3keeA-2fqxA:
undetectable		 3keeA-2fqxA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O1C_A_ADNA127_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 1)		 4xba APRATAXIN-LIKE
PROTEIN
(Schizosaccharomy
ces
pombe) 		5 / 10 ASP A  63
LEU A  73
SER A 142
HIS A 147
HIS A 149
 GMP  A 301 (-2.7A)
None
GMP  A 301 ( 4.0A)
GMP  A 301 (-3.9A)
GMP  A 301 (-4.8A)
 0.42A 3o1cA-4xbaA:
8.0		 3o1cA-4xbaA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O1X_A_ADNA1450_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 1)		 4xba APRATAXIN-LIKE
PROTEIN
(Schizosaccharomy
ces
pombe) 		5 / 10 ASP A  63
LEU A  73
SER A 142
HIS A 147
HIS A 149
 GMP  A 301 (-2.7A)
None
GMP  A 301 ( 4.0A)
GMP  A 301 (-3.9A)
GMP  A 301 (-4.8A)
 0.40A 3o1xA-4xbaA:
8.0		 3o1xA-4xbaA:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QGZ_A_ADNA127_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 1)		 4xba APRATAXIN-LIKE
PROTEIN
(Schizosaccharomy
ces
pombe) 		5 / 10 ASP A  63
LEU A  73
SER A 142
HIS A 147
HIS A 149
 GMP  A 301 (-2.7A)
None
GMP  A 301 ( 4.0A)
GMP  A 301 (-3.9A)
GMP  A 301 (-4.8A)
 0.40A 3qgzA-4xbaA:
8.1		 3qgzA-4xbaA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9W_A_VGHA1158_1
(7,8-DIHYDRO-8-OXOGUA
NINE TRIPHOSPHATASE)		 2fqx MEMBRANE LIPOPROTEIN
TMPC
(Treponema
pallidum) 		5 / 12 LEU A 105
MET A  24
VAL A  82
PHE A  36
GLN A  39
 None
None
None
GMP  A 400 (-3.8A)
None
 1.26A 4c9wA-2fqxA:
0.2		 4c9wA-2fqxA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PEV_A_ADNA501_1
(MEMBRANE LIPOPROTEIN
FAMILY PROTEIN)		 2fqx MEMBRANE LIPOPROTEIN
TMPC
(Treponema
pallidum) 		7 / 12 ASP A  27
SER A  35
ASN A  37
ASP A 108
PHE A 161
PHE A 186
GLY A 212
 GMP  A 400 (-2.9A)
GMP  A 400 ( 4.6A)
GMP  A 400 (-3.3A)
GMP  A 400 (-3.3A)
GMP  A 400 ( 4.8A)
GMP  A 400 (-3.4A)
GMP  A 400 (-3.3A)
 0.98A 4pevA-2fqxA:
39.8		 4pevA-2fqxA:
28.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PEV_A_ADNA501_1
(MEMBRANE LIPOPROTEIN
FAMILY PROTEIN)		 2fqx MEMBRANE LIPOPROTEIN
TMPC
(Treponema
pallidum) 		5 / 12 ASP A 263
VAL A 264
ASP A 238
PHE A 161
ASP A 108
 None
None
GMP  A 400 (-2.9A)
GMP  A 400 ( 4.8A)
GMP  A 400 (-3.3A)
 1.16A 4pevA-2fqxA:
39.8		 4pevA-2fqxA:
28.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PEV_A_ADNA501_1
(MEMBRANE LIPOPROTEIN
FAMILY PROTEIN)		 2fqx MEMBRANE LIPOPROTEIN
TMPC
(Treponema
pallidum) 		9 / 12 SER A  35
PHE A  36
ASN A  37
ASP A 108
PHE A 161
PHE A 186
GLY A 212
ASP A 238
LYS A 260
 GMP  A 400 ( 4.6A)
GMP  A 400 (-3.8A)
GMP  A 400 (-3.3A)
GMP  A 400 (-3.3A)
GMP  A 400 ( 4.8A)
GMP  A 400 (-3.4A)
GMP  A 400 (-3.3A)
GMP  A 400 (-2.9A)
GMP  A 400 (-2.8A)
 0.70A 4pevA-2fqxA:
39.8		 4pevA-2fqxA:
28.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PEV_B_ADNB501_1
(MEMBRANE LIPOPROTEIN
FAMILY PROTEIN)		 2fqx MEMBRANE LIPOPROTEIN
TMPC
(Treponema
pallidum) 		7 / 12 ASP A  27
SER A  35
ASN A  37
ASP A 108
PHE A 161
PHE A 186
GLY A 212
 GMP  A 400 (-2.9A)
GMP  A 400 ( 4.6A)
GMP  A 400 (-3.3A)
GMP  A 400 (-3.3A)
GMP  A 400 ( 4.8A)
GMP  A 400 (-3.4A)
GMP  A 400 (-3.3A)
 0.93A 4pevB-2fqxA:
39.7		 4pevB-2fqxA:
28.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PEV_B_ADNB501_1
(MEMBRANE LIPOPROTEIN
FAMILY PROTEIN)		 2fqx MEMBRANE LIPOPROTEIN
TMPC
(Treponema
pallidum) 		5 / 12 ASP A 263
VAL A 264
ASP A 238
PHE A 161
ASP A 108
 None
None
GMP  A 400 (-2.9A)
GMP  A 400 ( 4.8A)
GMP  A 400 (-3.3A)
 1.22A 4pevB-2fqxA:
39.7		 4pevB-2fqxA:
28.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PEV_B_ADNB501_1
(MEMBRANE LIPOPROTEIN
FAMILY PROTEIN)		 2fqx MEMBRANE LIPOPROTEIN
TMPC
(Treponema
pallidum) 		10 / 12 SER A  35
PHE A  36
ASN A  37
GLY A  85
ASP A 108
PHE A 161
PHE A 186
GLY A 212
ASP A 238
LYS A 260
 GMP  A 400 ( 4.6A)
GMP  A 400 (-3.8A)
GMP  A 400 (-3.3A)
GMP  A 400 ( 3.7A)
GMP  A 400 (-3.3A)
GMP  A 400 ( 4.8A)
GMP  A 400 (-3.4A)
GMP  A 400 (-3.3A)
GMP  A 400 (-2.9A)
GMP  A 400 (-2.8A)
 0.84A 4pevB-2fqxA:
39.7		 4pevB-2fqxA:
28.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PEV_C_ADNC501_1
(MEMBRANE LIPOPROTEIN
FAMILY PROTEIN)		 2fqx MEMBRANE LIPOPROTEIN
TMPC
(Treponema
pallidum) 		7 / 12 ASP A  27
SER A  35
ASN A  37
ASP A 108
PHE A 161
PHE A 186
GLY A 212
 GMP  A 400 (-2.9A)
GMP  A 400 ( 4.6A)
GMP  A 400 (-3.3A)
GMP  A 400 (-3.3A)
GMP  A 400 ( 4.8A)
GMP  A 400 (-3.4A)
GMP  A 400 (-3.3A)
 0.88A 4pevC-2fqxA:
39.5		 4pevC-2fqxA:
28.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PEV_C_ADNC501_1
(MEMBRANE LIPOPROTEIN
FAMILY PROTEIN)		 2fqx MEMBRANE LIPOPROTEIN
TMPC
(Treponema
pallidum) 		5 / 12 ASP A 263
VAL A 264
ASP A 238
PHE A 161
ASP A 108
 None
None
GMP  A 400 (-2.9A)
GMP  A 400 ( 4.8A)
GMP  A 400 (-3.3A)
 1.07A 4pevC-2fqxA:
39.5		 4pevC-2fqxA:
28.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PEV_C_ADNC501_1
(MEMBRANE LIPOPROTEIN
FAMILY PROTEIN)		 2fqx MEMBRANE LIPOPROTEIN
TMPC
(Treponema
pallidum) 		9 / 12 SER A  35
PHE A  36
ASN A  37
ASP A 108
PHE A 161
PHE A 186
GLY A 212
ASP A 238
LYS A 260
 GMP  A 400 ( 4.6A)
GMP  A 400 (-3.8A)
GMP  A 400 (-3.3A)
GMP  A 400 (-3.3A)
GMP  A 400 ( 4.8A)
GMP  A 400 (-3.4A)
GMP  A 400 (-3.3A)
GMP  A 400 (-2.9A)
GMP  A 400 (-2.8A)
 0.59A 4pevC-2fqxA:
39.5		 4pevC-2fqxA:
28.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UDC_A_DEXA1778_1
(GLUCOCORTICOID
RECEPTOR)		 2fqx MEMBRANE LIPOPROTEIN
TMPC
(Treponema
pallidum) 		5 / 12 MET A 158
LEU A 160
GLY A 164
MET A 258
PHE A 149
 GMP  A 400 (-3.5A)
None
None
None
None
 1.46A 4udcA-2fqxA:
undetectable		 4udcA-2fqxA:
24.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KLA_A_ACTA1505_0
(MATERNAL PROTEIN
PUMILIO)		 4xba APRATAXIN-LIKE
PROTEIN
(Schizosaccharomy
ces
pombe) 		3 / 3 HIS A 155
LYS A  67
PHE A 169
 None
GMP  A 301 (-2.9A)
None
 1.18A 5klaA-4xbaA:
undetectable		 5klaA-4xbaA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGL_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 2fqx MEMBRANE LIPOPROTEIN
TMPC
(Treponema
pallidum) 		3 / 3 VAL A 151
VAL A 210
GLN A 124
 None
GMP  A 400 (-4.0A)
GMP  A 400 ( 4.7A)
 0.68A 5qglA-2fqxA:
undetectable		 5qglA-2fqxA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGU_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 2fqx MEMBRANE LIPOPROTEIN
TMPC
(Treponema
pallidum) 		3 / 3 VAL A 151
VAL A 210
GLN A 124
 None
GMP  A 400 (-4.0A)
GMP  A 400 ( 4.7A)
 0.69A 5qguA-2fqxA:
undetectable		 5qguA-2fqxA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGV_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 2fqx MEMBRANE LIPOPROTEIN
TMPC
(Treponema
pallidum) 		3 / 3 VAL A 151
VAL A 210
GLN A 124
 None
GMP  A 400 (-4.0A)
GMP  A 400 ( 4.7A)
 0.70A 5qgvA-2fqxA:
undetectable		 5qgvA-2fqxA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGW_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 2fqx MEMBRANE LIPOPROTEIN
TMPC
(Treponema
pallidum) 		3 / 3 VAL A 151
VAL A 210
GLN A 124
 None
GMP  A 400 (-4.0A)
GMP  A 400 ( 4.7A)
 0.70A 5qgwA-2fqxA:
undetectable		 5qgwA-2fqxA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGX_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 2fqx MEMBRANE LIPOPROTEIN
TMPC
(Treponema
pallidum) 		3 / 3 VAL A 151
VAL A 210
GLN A 124
 None
GMP  A 400 (-4.0A)
GMP  A 400 ( 4.7A)
 0.70A 5qgxA-2fqxA:
undetectable		 5qgxA-2fqxA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QH1_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 2fqx MEMBRANE LIPOPROTEIN
TMPC
(Treponema
pallidum) 		3 / 3 VAL A 151
VAL A 210
GLN A 124
 None
GMP  A 400 (-4.0A)
GMP  A 400 ( 4.7A)
 0.70A 5qh1A-2fqxA:
undetectable		 5qh1A-2fqxA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QHC_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 2fqx MEMBRANE LIPOPROTEIN
TMPC
(Treponema
pallidum) 		3 / 3 VAL A 151
VAL A 210
GLN A 124
 None
GMP  A 400 (-4.0A)
GMP  A 400 ( 4.7A)
 0.70A 5qhcA-2fqxA:
undetectable		 5qhcA-2fqxA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QHE_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 2fqx MEMBRANE LIPOPROTEIN
TMPC
(Treponema
pallidum) 		3 / 3 VAL A 151
VAL A 210
GLN A 124
 None
GMP  A 400 (-4.0A)
GMP  A 400 ( 4.7A)
 0.68A 5qheA-2fqxA:
undetectable		 5qheA-2fqxA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QHF_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 2fqx MEMBRANE LIPOPROTEIN
TMPC
(Treponema
pallidum) 		3 / 3 VAL A 151
VAL A 210
GLN A 124
 None
GMP  A 400 (-4.0A)
GMP  A 400 ( 4.7A)
 0.72A 5qhfA-2fqxA:
undetectable		 5qhfA-2fqxA:
20.83