SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'GMG'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1FMO_E_ADNE351_1
(CAMP-DEPENDENT
PROTEIN KINASE)		 3hdn SERINE/THREONINE-PRO
TEIN KINASE SGK1
(Homo
sapiens) 		7 / 12 GLY A 105
VAL A 112
ALA A 125
VAL A 160
ASN A 227
LEU A 229
THR A 239
 None
None
GMG  A   1 (-3.4A)
None
GMG  A   1 ( 4.9A)
GMG  A   1 ( 4.9A)
GMG  A   1 (-3.8A)
 0.64A 1fmoE-3hdnA:
25.0		 1fmoE-3hdnA:
39.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FUP_A_MI1A1_1
(TYROSINE-PROTEIN
KINASE JAK2)		 3hdn SERINE/THREONINE-PRO
TEIN KINASE SGK1
(Homo
sapiens) 		8 / 12 GLY A 105
GLY A 107
GLY A 110
VAL A 112
ALA A 125
LYS A 127
TYR A 178
LEU A 229
 None
GMG  A   1 (-3.3A)
None
None
GMG  A   1 (-3.4A)
GMG  A   1 (-3.0A)
GMG  A   1 ( 4.9A)
GMG  A   1 ( 4.9A)
 0.73A 3fupA-3hdnA:
19.9		 3fupA-3hdnA:
25.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V5W_A_8PRA701_1
(G-PROTEIN COUPLED
RECEPTOR KINASE 2)		 3hdn SERINE/THREONINE-PRO
TEIN KINASE SGK1
(Homo
sapiens) 		6 / 12 ILE A 104
GLY A 107
GLY A 110
VAL A 112
ALA A 125
VAL A 160
 GMG  A   1 (-4.3A)
GMG  A   1 (-3.3A)
None
None
GMG  A   1 (-3.4A)
None
 0.78A 3v5wA-3hdnA:
10.9		 3v5wA-3hdnA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CKI_A_ADNA2022_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET)		 3hdn SERINE/THREONINE-PRO
TEIN KINASE SGK1
(Homo
sapiens) 		6 / 11 GLY A 105
GLY A 107
VAL A 112
ALA A 125
TYR A 178
LEU A 229
 None
GMG  A   1 (-3.3A)
None
GMG  A   1 (-3.4A)
GMG  A   1 ( 4.9A)
GMG  A   1 ( 4.9A)
 0.86A 4ckiA-3hdnA:
15.5		 4ckiA-3hdnA:
25.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IFG_A_1E8A601_1
(CALMODULIN-DOMAIN
PROTEIN KINASE 1)		 3hdn SERINE/THREONINE-PRO
TEIN KINASE SGK1
(Homo
sapiens) 		7 / 12 GLY A 105
VAL A 112
ALA A 125
LEU A 162
GLY A 182
GLU A 183
LEU A 229
 None
None
GMG  A   1 (-3.4A)
None
GMG  A   1 ( 4.0A)
None
GMG  A   1 ( 4.9A)
 0.84A 4ifgA-3hdnA:
24.7		 4ifgA-3hdnA:
28.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5IZF_E_AZ1E2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
6J9-ZEU-DAR-ACA-DAR-
NH2)		 3hdn SERINE/THREONINE-PRO
TEIN KINASE SGK1
(Homo
sapiens) 		5 / 7 GLY A 105
GLY A 107
SER A 108
PHE A 109
GLU A 183
 None
GMG  A   1 (-3.3A)
None
None
None
 1.00A 5izfA-3hdnA:
24.6		 5izfA-3hdnA:
38.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5IZJ_F_AZ1F2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAR-DAR-DAR)		 3hdn SERINE/THREONINE-PRO
TEIN KINASE SGK1
(Homo
sapiens) 		5 / 7 GLY A 105
GLY A 107
SER A 108
GLY A 110
LEU A 129
 None
GMG  A   1 (-3.3A)
None
None
None
 1.16A 5izjB-3hdnA:
28.5		 5izjB-3hdnA:
38.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5LVN_A_ADNA402_1
(3-PHOSPHOINOSITIDE-D
EPENDENT PROTEIN
KINASE 1)		 3hdn SERINE/THREONINE-PRO
TEIN KINASE SGK1
(Homo
sapiens) 		7 / 11 GLY A 105
VAL A 112
ALA A 125
LEU A 176
TYR A 178
GLU A 183
LEU A 229
 None
None
GMG  A   1 (-3.4A)
GMG  A   1 (-4.5A)
GMG  A   1 ( 4.9A)
None
GMG  A   1 ( 4.9A)
 0.63A 5lvnA-3hdnA:
28.4		 5lvnA-3hdnA:
34.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5LVN_A_ADNA402_1
(3-PHOSPHOINOSITIDE-D
EPENDENT PROTEIN
KINASE 1)		 3hdn SERINE/THREONINE-PRO
TEIN KINASE SGK1
(Homo
sapiens) 		7 / 11 GLY A 105
VAL A 112
ALA A 125
VAL A 160
LEU A 176
TYR A 178
GLU A 183
 None
None
GMG  A   1 (-3.4A)
None
GMG  A   1 (-4.5A)
GMG  A   1 ( 4.9A)
None
 0.75A 5lvnA-3hdnA:
28.4		 5lvnA-3hdnA:
34.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5N3H_A_NCAA401_0
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA)		 3hdn SERINE/THREONINE-PRO
TEIN KINASE SGK1
(Homo
sapiens) 		6 / 10 VAL A 112
ALA A 125
VAL A 160
TYR A 178
LEU A 229
THR A 239
 None
GMG  A   1 (-3.4A)
None
GMG  A   1 ( 4.9A)
GMG  A   1 ( 4.9A)
GMG  A   1 (-3.8A)
 0.76A 5n3hA-3hdnA:
29.6		 5n3hA-3hdnA:
39.37