SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'GM3'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IBG_H_OBNH1_1
(IGG2B-KAPPA 40-50
FAB (HEAVY CHAIN))		 2bv7 GLYCOLIPID TRANSFER
PROTEIN
(Bos
taurus) 		4 / 6 HIS A 140
LEU A 136
PHE A 148
VAL A 144
 GM3  A1212 (-3.6A)
GM3  A1212 (-4.3A)
GM3  A1212 (-4.6A)
None
 1.02A 1ibgH-2bv7A:
undetectable		 1ibgH-2bv7A:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X9G_A_LYAA1270_2
(PTERIDINE REDUCTASE)		 2bv7 GLYCOLIPID TRANSFER
PROTEIN
(Bos
taurus) 		3 / 3 MET A 134
VAL A 209
GLU A 204
 None
GM3  A1212 (-4.6A)
SO4  A1210 ( 4.8A)
 0.82A 2x9gA-2bv7A:
undetectable		 2x9gA-2bv7A:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R0L_D_ACTD127_0
(PHOSPHOLIPASE A2 CB)		 2bv7 GLYCOLIPID TRANSFER
PROTEIN
(Bos
taurus) 		4 / 5 PHE A 148
ILE A  45
GLY A 100
HIS A 140
 GM3  A1212 (-4.6A)
GM3  A1212 (-4.4A)
GM3  A1212 ( 3.7A)
GM3  A1212 (-3.6A)
 1.24A 3r0lD-2bv7A:
undetectable		 3r0lD-2bv7A:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HNZ_B_TA1B902_2
(TUBULIN BETA-2B
CHAIN)		 2bv7 GLYCOLIPID TRANSFER
PROTEIN
(Bos
taurus) 		3 / 3 LEU A 101
LEU A  30
ARG A 181
 None
GM3  A1212 ( 4.8A)
None
 0.58A 5hnzB-2bv7A:
undetectable		 5hnzB-2bv7A:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMP_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2bv7 GLYCOLIPID TRANSFER
PROTEIN
(Bos
taurus) 		4 / 7 ILE A 111
LEU A 108
ARG A 125
LEU A  37
 None
GM3  A1212 ( 4.9A)
None
None
 0.91A 6nmpA-2bv7A:
2.2
6nmpJ-2bv7A:
undetectable		 6nmpA-2bv7A:
18.09
6nmpJ-2bv7A:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMP_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2bv7 GLYCOLIPID TRANSFER
PROTEIN
(Bos
taurus) 		4 / 5 ILE A 111
LEU A 108
ARG A 125
LEU A  37
 None
GM3  A1212 ( 4.9A)
None
None
 0.92A 6nmpN-2bv7A:
1.9
6nmpW-2bv7A:
undetectable		 6nmpN-2bv7A:
18.09
6nmpW-2bv7A:
15.38