SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'GLV'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQW_A_RTLA135_0
(CELLULAR
RETINOL-BINDING
PROTEIN)		 2bkw ALANINE-GLYOXYLATE
AMINOTRANSFERASE 1
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 344
THR A 142
THR A 144
VAL A  91
LEU A 196
 GLV  A1384 ( 4.3A)
None
PLP  A1201 (-4.3A)
None
None
 1.30A 1kqwA-2bkwA:
undetectable		 1kqwA-2bkwA:
15.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M2Z_D_DEXD401_1
(GLUCOCORTICOID
RECEPTOR)		 5aov GLYOXYLATE REDUCTASE
(Pyrococcus
furiosus) 		5 / 12 ASN A  80
GLY A  77
ARG A 160
ILE A  57
LEU A  53
 None
GLV  A1336 (-3.3A)
NAP  A1335 (-3.3A)
None
GLV  A1356 ( 3.7A)
 1.46A 1m2zD-5aovA:
undetectable		 1m2zD-5aovA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IEN_B_017B402_1
(PROTEASE)		 1nxj PROBABLE
S-ADENOSYLMETHIONINE
:2-DEMETHYLMENAQUINO
NE METHYLTRANSFERASE
(Mycobacterium
tuberculosis) 		5 / 12 GLY A 153
VAL A 156
GLY A 137
VAL A  19
ILE A 155
 GLV  A 741 ( 4.5A)
None
None
None
None
 0.93A 2ienA-1nxjA:
undetectable		 2ienA-1nxjA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G2O_A_SAMA500_1
(PCZA361.24)		 1d8c MALATE SYNTHASE G
(Escherichia
coli) 		3 / 3 ARG A 338
GLU A 359
ASP A 279
 GLV  A2000 (-3.6A)
None
None
 0.87A 3g2oA-1d8cA:
0.2		 3g2oA-1d8cA:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R0L_D_ACTD127_0
(PHOSPHOLIPASE A2 CB)		 1nxj PROBABLE
S-ADENOSYLMETHIONINE
:2-DEMETHYLMENAQUINO
NE METHYLTRANSFERASE
(Mycobacterium
tuberculosis) 		4 / 5 PHE A  26
ILE A  94
GLY A 153
CYH A  22
 None
None
GLV  A 741 ( 4.5A)
None
 1.33A 3r0lD-1nxjA:
undetectable		 3r0lD-1nxjA:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L78_A_ACTA1327_0
(PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
SYNTHASE)		 2ete OXALATE OXIDASE 1
(Hordeum
vulgare) 		4 / 4 VAL A  56
THR A  57
GLU A  58
GLU A  63
 GLV  A 404 ( 4.7A)
None
None
None
 1.12A 4l78A-2eteA:
undetectable		 4l78A-2eteA:
10.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QYN_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 2)		 2bkw ALANINE-GLYOXYLATE
AMINOTRANSFERASE 1
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 344
THR A 142
THR A 144
VAL A  91
LEU A 196
 GLV  A1384 ( 4.3A)
None
PLP  A1201 (-4.3A)
None
None
 1.25A 4qynA-2bkwA:
undetectable		 4qynA-2bkwA:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_D_SORD1343_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 5e9g ISOCITRATE LYASE
(Magnaporthe
oryzae) 		4 / 5 ALA A 125
HIS A 204
ALA A 178
GLU A 206
 None
GLV  A 601 (-4.6A)
None
MG  A 603 ( 4.7A)
 1.15A 5a06C-5e9gA:
undetectable
5a06D-5e9gA:
undetectable		 5a06C-5e9gA:
19.46
5a06D-5e9gA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JCN_B_ASCB502_0
(OS09G0567300 PROTEIN)		 2bkw ALANINE-GLYOXYLATE
AMINOTRANSFERASE 1
(Saccharomyces
cerevisiae) 		4 / 6 GLY A 343
ARG A 354
PHE A  97
ARG A 100
 None
GLV  A1384 (-2.5A)
PLP  A1201 (-4.1A)
None
 1.14A 5jcnB-2bkwA:
undetectable		 5jcnB-2bkwA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUO_D_PFLD402_1
(PROTON-GATED ION
CHANNEL)		 2bkw ALANINE-GLYOXYLATE
AMINOTRANSFERASE 1
(Saccharomyces
cerevisiae) 		5 / 9 THR A 150
SER A 149
ILE A 344
THR A  94
THR A 144
 None
None
GLV  A1384 ( 4.3A)
None
PLP  A1201 (-4.3A)
 1.50A 5muoA-2bkwA:
0.0
5muoB-2bkwA:
0.0
5muoC-2bkwA:
0.0
5muoD-2bkwA:
0.0
5muoE-2bkwA:
0.0		 5muoA-2bkwA:
12.57
5muoB-2bkwA:
12.57
5muoC-2bkwA:
12.57
5muoD-2bkwA:
12.57
5muoE-2bkwA:
12.57